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26 results on '"Rocha, F.G."'

3. Posthepatectomy liver failure despite preoperative portal vein embolization: not just about the volumetrics

Author

Li, A.Y., primary, Sofilos, M.C., additional, Bergquist, J.R., additional, Sze, D.Y., additional, Lee, R.M., additional, Ermentrout, R.M., additional, Maithel, S.K., additional, Lee, T.C., additional, Chadalavada, S., additional, Shah, S.A., additional, Acher, A., additional, Machhi, R., additional, Abbott, D.E., additional, Wong, P., additional, Kessler, J., additional, Melstrom, L.G., additional, Kirks, R., additional, Rocha, F.G., additional, Dua, M.M., additional, Lee, B., additional, Norton, J.A., additional, Visser, B.C., additional, and Poultsides, G.A., additional

Published
2021
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6. Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference.

Author

Kumar, N., Rocha, F.G., Moustafa, A.S.Z., Masten, M., Bruder, A., Parmar, K., Adekola, H., Sampath, V., and Monga, R.

Subjects
*BIRTH weight, *NEONATAL abstinence syndrome, *METHADONE treatment programs, *OPIOIDS, *MOTHER-infant relationship
Abstract

BACKGROUND: Pregnant mothers with opioid dependency commonly receive maintenance treatment of opioid (OMT), either as buprenorphine (BMT) or methadone maintenance treatment (MMT). We investigated, whether OMT adversely affects standardized neonatal anthropometric outcomes and whether BMT is potentially safer than MMT in this regard. METHODS: Retrospective chart review of mother infant dyad, with and without OMT. Infant's absolute and standardized (z-score) anthropometric outcomes at birth were first compared, between OMT and control group (negative meconium drug screen), and then between BMT and MMT group. These outcomes were also compared between infants who did or did not require treatment after birth for neonatal abstinence syndrome (NAS). RESULT: A total of 1479 participants with MDS were included [Control = 1251; OMT = 228 (MMT = 181; BMT = 47)]. Both the z-scores of birth weight (BW) and head circumference (HC) was lower in OMT group (p < 0.001). Among the OMT group, GA at delivery was slightly higher in the BMT group (p = 0.05). There was an inverse correlation between maternal dose at the time of delivery and anthropometric z-scores in the BMT group, mainly in female infants (BW: p = 0.006; HC: p = 0.003). Furthermore, In BMT group, infants with lower HC were more likely to require treatment for NAS (p = 0.01). CONCLUSION: HC and BW when comparing Z-scores were not different between MMT and BMT. High maternal dosing of buprenorphine is associated with lower BW and HC Z-scores but dose effect is not seen with methadone. In addition, there seems to be an association between NAS severity and HC, especially in the BMT group. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Insulin-dependence predicts disease-specific survival in pancreatic neuroendocrine tumor patients

Author

Baechle, J.J., primary, Smith, P.M., additional, Bailey, C.E., additional, Lopez-Aguiar, A.G., additional, Dillhoff, M., additional, Beal, E.W., additional, Poultsides, G., additional, Makris, E., additional, Rocha, F.G., additional, Crown, A., additional, Nathan, H., additional, Beems, M., additional, Winslow, E.R., additional, Rendell, V.R., additional, Krasnick, B.A., additional, Fields, R., additional, Maithel, S.K., additional, and Idrees, K., additional

Published
2019
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15. Sphingolipid Synthesis Limits the Host Inflammatory Response.

Author

Rocha, F.G., Moye, Z.D., Ottenberg, G., Tang, P., Campopiano, D.J., Gibson III, F.C., Davey, M.E., and Gibson, F C 3rd

Subjects
SPHINGOLIPIDS, INFLAMMATION, PORPHYROMONAS gingivalis, SERINE palmitoyltransferase, HOMEOSTASIS, GENE expression, BACTEROIDETES, GRAM-negative anaerobic bacteria, MACROPHAGES, RESEARCH funding, LIPIDS
Abstract

Porphyromonas gingivalis, like other bacteria belonging to the phylum Bacteroidetes, synthesizes sphingolipids (SLs). However, their exact roles in microbial physiology and their potential role in mediating interactions with their eukaryotic host are unclear. Our working hypothesis for this study was that synthesis of SLs (host-like lipids) affords a mechanism that allows P. gingivalis to persist in homeostasis with its host. In a previous study, we deleted a gene (PG1780 in strain W83) predicted to encode a serine palmitoyl transferase (SPT)-the enzyme that catalyzes the first conserved step in the synthesis of SLs-and we determined that the mutant was unable to synthesize SLs. Here, we characterized the SPT enzyme encoded by PG1780, analyzed the impact of SPT deletion on P. gingivalis gene expression (RNA-Seq analysis), and began to define the impact of SL synthesis on its interactions with host cells. Enzymatic analysis verified that the protein encoded by PG1780 is indeed an SPT. RNA-Seq analysis determined that a lack of SL synthesis results in differential expression of extracytoplasmic function sigma factors, components of the type IX secretion system (T9SS), and CRISPR and cas genes. Our data demonstrate that when human THP1 macrophage-like cells were challenged with the wild type (W83) and the SL-null mutant (W83 ΔSPT), the SL-null strain elicited a robust inflammatory response (elevated IL-1β, IL-6, IL-10, IL-8, RANTES, and TNFα) while the response to the parent strain W83 was negligible. Interestingly, we also discovered that SLs produced by P. gingivalis can be delivered to host cells independent of cell-to-cell contact. Overall, our results support our working hypothesis that synthesis of SLs by P. gingivalis is central to its ability to manipulate the host inflammatory response, and they demonstrate the integral importance of SLs in the physiology of P. gingivalis. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Evaluating the ACS-NSQIP risk calculator in primary pancreatic neuroendocrine tumor: results from the united states neuroendocrine tumor study group

Author

Beal, E.W., primary, Kearney, J., additional, Lyon, E., additional, Lopez-Aquiar, A.G., additional, Poultsides, G., additional, Makris, E., additional, Rocha, F.G., additional, Kanji, Z., additional, Ronnekleiv-Kelly, S., additional, Rendell, V.R., additional, Fields, R., additional, Krasnick, B.A., additional, Idrees, K., additional, Marincola Smith, P., additional, Nathan, H., additional, Beems, M., additional, Maithel, S.K., additional, Schmidt, C.R., additional, and Dillhoff, M., additional

Published
2018
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17. The impact of failure to achieve symptom control after resection of functional neuroendocrine tumors: an 8-institution study from the us neuroendocrine tumor study group

Author

Zaidi, M.Y., primary, Lopez-Aguiar, A.G., additional, Poultsides, G.A., additional, Makris, E., additional, Dillhoff, M., additional, Beal, E.W., additional, Rocha, F.G., additional, Kanji, Z.S., additional, Idrees, K., additional, Marincola Smith, P., additional, Nathan, H., additional, Beems, M., additional, Winslow, E.R., additional, Barrett, J.R., additional, Fields, R.C., additional, Krasnick, B.A., additional, Cardona, K., additional, and Maithel, S.K., additional

Published
2018
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19. Calcifications and cystic morphology on preoperative imaging predict survival after resection of pancreatic neuroendocrine tumors

Author

Makris, E.A., primary, Cannon, J.G.D., additional, Norton, J.A., additional, Lopez-Aguiar, A.G., additional, Dillhoff, M., additional, Beal, E., additional, Idrees, K., additional, Smith, P.M., additional, Rocha, F.G., additional, Kanji, Z., additional, Cho, C.S., additional, Beems, M., additional, Weber, S.M., additional, Fisher, A., additional, Krasnick, B.A., additional, Fields, R.C., additional, Maithel, S.K., additional, and Poultsides, G.A., additional

Published
2018
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20. Effect of blood transfusion on survival for resected pancreatic neuroendocrine tumors: analysis of the U.S. neuroendocrine study group

Author

Marincola Smith, P., primary, Bailey, C.E., additional, Solñ rzano, C.C., additional, Lopez-Aguiar, A.G., additional, Dillhoff, M., additional, Beal, E., additional, Poultsides, G., additional, Makris, E., additional, Rocha, F.G., additional, Crown, A., additional, Cho, C., additional, Beems, M., additional, Winslow, E.R., additional, Rendell, V.R., additional, Krasnick, B.A., additional, Fields, R.C., additional, Maithel, S.K., additional, and Idrees, K., additional

Published
2018
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21. Recurrent or metachronous adenocarcinoma of the pancreatic remnant: long-term survival after completion pancreatectomy

Author

Tran, T.B., primary, Norton, J.A., additional, Maker, A.V., additional, Krasnick, B.A., additional, Ethun, C.G., additional, Cameron, J.L., additional, Maithel, S.K., additional, Rocha, F.G., additional, He, J., additional, Javed, A.A., additional, Fields, R.C., additional, Wolfgang, C.L., additional, Weiss, M.J., additional, and Poultsides, G.A., additional

Published
2018
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24. P198

Author

Balakrishnan, A., primary, Rocha, F.G., additional, Tavakkolizadeh, A., additional, Rhoads, D., additional, and Ashley, S.W., additional

Published
2007
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