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Introduction: Non-metastatic, castration-resistant prostate cancer (nmCRPC) is an important clinical stage of prostate cancer, prior to morbidity and mortality from clinical metastases. In particular, the introduction of novel androgen-receptor signaling inhibitors (ARSi) has changed the therapeutic landscape in nmCRPC. Given recent developments in this field, we update our recommendations for the management of nmCRPC., Methods: A panel of 51 invited medical oncologists and urologists convened in May of 2021 with the aim of discussing and providing recommendations regarding the most relevant issues concerning staging methods, antineoplastic therapy, osteoclast-targeted therapy, and patient follow-up in nmCRPC. Panel members considered the available evidence and their practical experience to address the 73 multiple-choice questions presented., Results: Key recommendations and findings include the reliance on prostate-specific antigen doubling time for treatment decisions, the absence of a clear preference between conventional and novel (i.e., positron-emission tomography-based) imaging techniques, the increasing role of ARSis in various settings, the general view that ARSis have similar efficacy. Panelists highlighted the slight preference for darolutamide, when safety is of greater concern, and a continued need to develop high-level evidence to guide the intensity of follow-up in this subset of prostate cancer., Discussion: Despite the limitations associated with a consensus panel, the topics addressed are relevant in current practice, and the recommendations can help practicing clinicians to provide state-of-the-art treatment to patients with nmCRPC in Brazil and other countries with similar healthcare settings., (Copyright © 2022. Published by Elsevier Inc.)

Anthocyanins are potential food colorants due to their color, low toxicity and biological properties. However, the low chemical stability of anthocyanins has limited their use. In this work, the thermal stability of cyanidin-3-O-glucoside (cy3glc) (major blackberry anthocyanin) and blackberry purees through molecular inclusion with β-cyclodextrin (β-CD) was assessed. Complexation with β-CD showed a thermal stabilization of cy3glc, resulting on a decrease of the degradation rate constant (k) and in several alterations in the cy3glc-β-CD DSC thermogram. To assess the bioaccessibility of blackberry anthocyanins, the stability of blackberry purees through simulated in vitro digestion was also studied. Despite the rapid degradation of anthocyanins observed within the first minutes of simulated intestinal digestion, complexation with β-CD allowed anthocyanins degradation to be slowed down. The results obtained demonstrate the ability of β-CD to increase blackberry anthocyanins thermal stability and also to decrease the rate of degradation of these pigments under simulated gastrointestinal conditions., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

The solubility of CO 2 in hydrophobic deep eutectic solvents (DESs) has been measured for the first time. Six different hydrophobic DESs are studied in the temperature range from 298 to 323 K and at CO 2 pressures up to 2 MPa. The results are evaluated by comparing the solubility data with existing hydrophilic DESs and currently applied physical solvents and fluorinated ionic liquids. The DESs are prepared by mixing decanoic acid with a quaternary ammonium salt with different halide anions and alkyl chain lengths. The measured CO 2 solubilities are similar to those found in renowned fluorinated ILs, while the heats of CO 2 absorption are in the range of nonpolar solvents. The presented DESs show good potential to be used as CO 2 capture agents., Competing Interests: The authors declare no competing financial interest.