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1. Chapter 1: The Astrobiology Primer 3.0

Author

Schaible, Micah J., primary, Szeinbaum, Nadia, additional, Bozdag, G. Ozan, additional, Chou, Luoth, additional, Grefenstette, Natalie, additional, Colón-Santos, Stephanie, additional, Rodriguez, Laura E., additional, Styczinski, M.J., additional, Thweatt, Jennifer L., additional, Todd, Zoe R., additional, Vázquez-Salazar, Alberto, additional, Adams, Alyssa, additional, Araújo, M.N., additional, Altair, Thiago, additional, Borges, Schuyler, additional, Burton, Dana, additional, Campillo-Balderas, José Alberto, additional, Cangi, Eryn M., additional, Caro, Tristan, additional, Catalano, Enrico, additional, Chen, Kimberly, additional, Conlin, Peter L., additional, Cooper, Z.S., additional, Fisher, Theresa M., additional, Fos, Santiago Mestre, additional, Garcia, Amanda, additional, Glaser, D.M., additional, Harman, Chester E., additional, Hermis, Ninos Y., additional, Hooks, M., additional, Johnson-Finn, K., additional, Lehmer, Owen, additional, Hernández-Morales, Ricardo, additional, Hughson, Kynan H.G., additional, Jácome, Rodrigo, additional, Jia, Tony Z., additional, Marlow, Jeffrey J., additional, McKaig, Jordan, additional, Mierzejewski, Veronica, additional, Muñoz-Velasco, Israel, additional, Nural, Ceren, additional, Oliver, Gina C., additional, Penev, Petar I., additional, Raj, Chinmayee Govinda, additional, Roche, Tyler P., additional, Sabuda, Mary C., additional, Schaible, George A., additional, Sevgen, Serhat, additional, Sinhadc, Pritvik, additional, Steller, Luke H., additional, Stelmach, Kamil, additional, Tarnas, J., additional, Tavares, Frank, additional, Trubl, Gareth, additional, Vidaurri, Monica, additional, Vincent, Lena, additional, Weber, Jessica M., additional, Weng, Maggie Meiqi, additional, Wilpiszeki, Regina L., additional, and Young, Amber, additional

Published
2024
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5. A Plausible Prebiotic Path to Nucleosides: Ribosides and Related Aldosides Generated from Ribulose, Fructose, and Similar Abiotic Precursors.

Author

Roche, Tyler P., Fialho, David M., Menor‐Salván, Cesar, Krishnamurthy, Ramanarayanan, Schuster, Gary B., and Hud, Nicholas V.

Subjects
*NUCLEOSIDES, *FRUCTOOLIGOSACCHARIDES, *MONOSACCHARIDES, *GLYCOSIDES, *RIBOSE, *FRUCTOSE, *SUGARS, *RIBONUCLEOSIDES
Abstract

The prebiotic origins of ribose, nucleosides, and eventually RNA are enduring questions whose answers are central to the RNA world hypothesis. The abiotic synthesis of sugars was first demonstrated over a century ago, but no known prebiotic reaction produces ribose (an aldose sugar) selectively and in good yield. In contrast, ribulose, and fructose (ketose sugars) and other monosaccharides are formed in high yield by several robust abiotic reactions. It is reported here that ketose sugars ‐ both ketopentoses and ketohexoes ‐ serve as precursors for the formation of ribosides and other aldosides, as demonstrated by glycoside‐forming reactions involving barbituric acid, a plausibly prebiotic nucleobase. Moreover, a one‐pot reaction of glyceraldehyde and barbituric acid was discovered which under mild conditions, and without special minerals or other catalysts, results in the formation of glycosides. These results reveal that an exclusive or high‐yielding generation of free ribose was not required for its incorporation into processes that provided the foundations for life. [ABSTRACT FROM AUTHOR]

Published
2023
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