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1. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Roden, M., Al-Hasani, H., Belgardt, B., Lammert, E., Bönhof, G., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., Kotzka, J., Kuß, O., Rathmann, W., Schlesinger, S., Schrauwen-Hinderling, V., Szendroedi, J., Trenkamp, S., Wagner, R., Weber, Katharina S., Schlesinger, Sabrina, Lang, Alexander, Straßburger, Klaus, Maalmi, Haifa, Zhu, Anna, Zaharia, Oana-Patricia, Strom, Alexander, Bönhof, Gidon J., Goletzke, Janina, Trenkamp, Sandra, Wagner, Robert, Buyken, Anette E., Lieb, Wolfgang, Roden, Michael, and Herder, Christian

Published
2024
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3. Association of C-Terminal Pro-Endothelin-1 with Mortality in the Population-Based KORA F4 Study

Author

Then C, Sujana C, Herder C, Then H, Heier M, Meisinger C, Peters A, Koenig W, Rathmann W, Maalmi H, Ritzel K, Roden M, Stumvoll M, Thorand B, and Seissler J

Subjects
endothelin, ct-proet-1, mortality, cardiovascular events, subclinical inflammation, intima-media thickness, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Cornelia Then,1,2 Chaterina Sujana,2– 4 Christian Herder,5– 7 Holger Then,8 Margit Heier,3,9 Christa Meisinger,10,11 Annette Peters,3,12 Wolfgang Koenig,12– 14 Wolfgang Rathmann,5,15 Haifa Maalmi,5,7 Katrin Ritzel,1 Michael Roden,5– 7 Michael Stumvoll,16 Barbara Thorand,2,3 Jochen Seissler1,2 1Department of Internal Medicine IV, University Hospital of Ludwigs-Maximilians-University Munich, Munich, Germany; 2German Center for Diabetes Research (DZD), Partner Munich-Neuherberg, Munich, Germany; 3Institute of Epidemiology, Helmholtz Zentrum Munich – German Research Center for Environmental Health (GmbH), Neuherberg, Germany; 4Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health, Ludwigs-Maximilians-University Munich, Munich, Germany; 5German Center for Diabetes Research (DZD), Munich, Germany; 6Department of Endocrinology and Diabetology, Medical Faculty and University Hospital of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; 7Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; 8Freie Waldorfschule Augsburg, Augsburg, Germany; 9KORA Study Centre, University Hospital Augsburg, Augsburg, Germany; 10Independent Research Group Clinical Epidemiology, Helmholtz Zentrum Munich – German Research Center for Environmental Health (GmbH), Neuherberg, Germany; 11Chair of Epidemiology, University Hospital Augsburg, Augsburg, Germany; 12DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; 13Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; 14German Heart Center Munich, Technical University of Munich, Munich, Germany; 15Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; 16Department of Medicine, University of Leipzig, Leipzig, GermanyCorrespondence: Cornelia Then, Medizinische Klinik und Poliklinik IV - Klinikum der Ludwig-Maximilians-Universität, Ziemssenstraße 1, München, 80336, Germany, Tel +4989440052111, Fax +4989440054956, Email cornelia.then@med.uni-muenchen.deIntroduction: Endothelin-1 and its prohormone C-terminal pro-endothelin-1 (CT-proET-1) have been linked to metabolic alterations, inflammatory responses and cardiovascular events in selected study populations. We analyzed the association of CT-proET-1 with cardiovascular events and mortality, carotid intima-media-thickness as surrogate for early atherosclerotic lesions, biomarkers of subclinical inflammation and adipokines in a population-based study.Methods: The cross-sectional and prospective analyses used data from the KORA F4 study with a median follow-up time of 9.1 (8.8– 9.4) years. Data on CT-proET-1 and mortality were available for 1554 participants, data on the other outcomes in subgroups (n = 596– 1554). The associations were estimated using multivariable linear regression and Cox proportional hazard models adjusted for sex, age, body mass index, estimated glomerular filtration rate, arterial hypertension, diabetes, low-density and high-density lipoprotein cholesterol, current and former smoking and physical activity. The Bonferroni method was used to correct for multiple testing.Results: In the fully adjusted model, CT-proET-1 was associated with cardiovascular (hazard ratio (HR) per standard deviation increase: 1.66; 95% confidence interval (CI): 1.10– 2.51; p = 0.017) and all-cause mortality (HR: 2.03; 95% CI 1.55– 2.67; p < 0.001), but not with cardiovascular events, and was inversely associated with the intima-media thickness (β: − 0.09 ± 0.03; p = 0.001). CT-proET-1 was positively associated with five out of ten biomarkers of subclinical inflammation and with two out of five adipokines after correction for multiple testing. After inclusion of biomarkers of subclinical inflammation in the Cox proportional hazard model, the association of CT-proET-1 with all-cause mortality persisted (p < 0.001).Conclusion: These results emphasize the complexity of endothelin-1 actions and/or indicator functions of CT-proET-1. CT-proET-1 is a risk marker for all-cause mortality, which is likely independent of vascular endothelin-1 actions, cardiovascular disease and inflammation.Keywords: endothelin, CT-proET-1, mortality, cardiovascular events, subclinical inflammation, intima-media thickness

Published
2022

6. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Weber, Katharina S., primary, Schlesinger, Sabrina, additional, Lang, Alexander, additional, Straßburger, Klaus, additional, Maalmi, Haifa, additional, Zhu, Anna, additional, Zaharia, Oana-Patricia, additional, Strom, Alexander, additional, Bönhof, Gidon J., additional, Goletzke, Janina, additional, Trenkamp, Sandra, additional, Wagner, Robert, additional, Buyken, Anette E., additional, Lieb, Wolfgang, additional, Roden, Michael, additional, Herder, Christian, additional, Roden, M., additional, Al-Hasani, H., additional, Belgardt, B., additional, Lammert, E., additional, Bönhof, G., additional, Geerling, G., additional, Herder, C., additional, Icks, A., additional, Jandeleit-Dahm, K., additional, Kotzka, J., additional, Kuß, O., additional, Rathmann, W., additional, Schlesinger, S., additional, Schrauwen-Hinderling, V., additional, Szendroedi, J., additional, Trenkamp, S., additional, and Wagner, R., additional

Published
2024
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7. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus

Author

Roden, M., Al-Hasani, H., Burkart, V., Buyken, A.E., Geerling, G., Hwang, J.H., Herder, C., Icks, A., Jandeleit-Dahm, K., Kahl, S., Kotzka, J., Kuss, O., Lammert, E., Trenkamp, S., Rathmann, W., Szendroedi, J., Ziegler, D., Kupriyanova, Yuliya, Zaharia, Oana Patricia, Bobrov, Pavel, Karusheva, Yanislava, Burkart, Volker, Szendroedi, Julia, Hwang, Jong-Hee, and Roden, Michael

Published
2021
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9. Cross-sectional association between substitution of carbohydrates with protein/fat and subcutaneous, visceral and liver adipose tissue volume in recent-onset diabetes

Author

Lang, A, Szczerba, E, Kupriyanova, Y, Goletzke, J, Weber, K, Buyken, AE, Kahl, S, Zaharia, OP, Herder, C, Schrauwen-Hinderling, VB, Kuß, O, Wagner, R, Roden, M, Schlesinger, S, Lang, A, Szczerba, E, Kupriyanova, Y, Goletzke, J, Weber, K, Buyken, AE, Kahl, S, Zaharia, OP, Herder, C, Schrauwen-Hinderling, VB, Kuß, O, Wagner, R, Roden, M, and Schlesinger, S

Published
2024

10. A global research priority agenda to advance public health responses to fatty liver disease

Author

Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Hagstrom, H, Huang, T, Wajcman, D, Kautz, A, Kopka, C, Krag, A, Miller, V, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Aberg, F, Adams, L, Al-Naamani, K, Albadawy, R, Alexa, Z, Allison, M, Alnaser, F, Alswat, K, Alvares-da-Silva, M, Alvaro, D, Alves-Bezerra, M, Andrade, R, Anstee, Q, Awuku, Y, Baatarkhuu, O, Baffy, G, Bakieva, S, Bansal, M, Barouki, R, Batterham, R, Behling, C, Belfort-DeAguiar, R, Berzigotti, A, Betel, M, Bianco, C, Bosi, E, Boursier, J, Brunt, E, Bugianesi, E, Byrne, C, Cabrera Cabrejos, M, Caldwell, S, Carr, R, Castellanos Fernandez, M, Castera, L, Castillo-Lopez, M, Caussy, C, Cerda-Reyes, E, Ceriello, A, Chan, W, Chang, Y, Charatcharoenwitthaya, P, Chavez-Tapia, N, Chung, R, Colombo, M, Coppell, K, Cotrim, H, Craxi, A, Crespo, J, Dassanayake, A, Davidson, N, De Knegt, R, de Ledinghen, V, Demir, M, Desalegn, H, Diago, M, Dillon, J, Dimmig, B, Dirac, M, Dirchwolf, M, Dufour, J, Dvorak, K, Ekstedt, M, El-Kassas, M, Elsanousi, O, Elsharkawy, A, Elwakil, R, Eskridge, W, Eslam, M, Esmat, G, Fan, J, Ferraz, M, Flisiak, R, Fortin, D, Fouad, Y, Freidman, S, Fuchs, M, Gadano, A, Gastaldelli, A, Geerts, A, Geier, A, George, J, Gerber, L, Ghazinyan, H, Gheorghe, L, Kile, D, Girala, M, Boon Bee, G, Goossens, N, Graupera, I, Gronbaek, H, Hamid, S, Hebditch, V, Henry, Z, Hickman, I, Hobbs, L, Hocking, S, Hofmann, W, Idilman, R, Iruzubieta, P, Isaacs, S, Isakov, V, Ismail, M, Jamal, M, Jarvis, H, Jepsen, P, Jornayvaz, F, Sudhamshu, K, Kakizaki, S, Karpen, S, Kawaguchi, T, Keating, S, Khader, Y, Kim, S, Kim, W, Kleiner, D, Koek, G, Joseph Komas, N, Kondili, L, Koot, B, Korenjak, M, Kotsiliti, E, Koulla, Y, Kugelmas, C, Kugelmas, M, Labidi, A, Lange, N, Lavine, J, Lazo, M, Leite, N, Lin, H, Lkhagvaa, U, Long, M, Lopez-Jaramillo, P, Lozano, A, Macedo, M, Malekzadeh, R, Marchesini, G, Marciano, S, Martinez, K, Martinez Vazquez, S, Mateva, L, Mato, J, Nlombi, C, Mccary, A, Mcintyre, J, Mckee, M, Mendive, J, Mikolasevic, I, Miller, P, Milovanovic, T, Milton, T, Moreno-Alcantar, R, Morgan, T, Motala, A, Muris, J, Musso, C, Nava-Gonzalez, E, Negro, F, Nersesov, A, Neuschwander-Tetri, B, Nikolova, D, Norris, S, Novak, K, Ocama, P, Ong, J, Ong-Go, A, Onyekwere, C, Padilla, M, Pais, R, Pan, C, Panduro, A, Panigrahi, M, Papatheodoridis, G, Paruk, I, Patel, K, Goncalves, C, Figueroa, M, Perez-Escobar, J, Pericas, J, Perseghin, G, Pessoa, M, Petta, S, Marques Souza de Oliveira, C, Prabhakaran, D, Pyrsopoulous, N, Rabiee, A, Ramji, A, Ratziu, V, Ravendhran, N, Ray, K, Roden, M, Romeo, S, Romero-Gomez, M, Rotman, Y, Rouabhia, S, Rowe, I, Sadirova, S, Alkhatry, M, Salupere, R, Satapathy, S, Schwimmer, J, Sebastiani, G, Seim, L, Seki, Y, Serme, A, Shapiro, D, Sharvadze, L, Shaw, J, Shawa, I, Shenoy, T, Shibolet, O, Shimakawa, Y, Shubrook, J, Singh, S, Sinkala, E, Skladany, L, Skrypnyk, I, Song, M, Sookoian, S, Sridharan, K, Stefan, N, Stine, J, Stratakis, N, Sheriff, D, Sundaram, S, Svegliati-Baroni, G, Swain, M, Tacke, F, Taheri, S, Tan, S, Tapper, E, Targher, G, Tcaciuc, E, Thiele, M, Tiniakos, D, Tolmane, I, Torre, A, Torres, E, Treeprasertsuk, S, Trenell, M, Turcan, S, Turcanu, A, Valantinas, J, van Kleef, L, Velarde Ruiz Velasco, J, Vesterhus, M, Vilar-Gomez, E, Waked, I, Wattacheril, J, Wedemeyer, H, Wilkins, F, Willemse, J, Wong, R, Yilmaz, Y, Yki-Jarvinen, H, Yu, M, Yumuk, V, Zeybel, M, Zheng, K, Zheng, M, Lazarus J. V., Mark H. E., Allen A. M., Arab J. P., Carrieri P., Noureddin M., Alazawi W., Alkhouri N., Alqahtani S. A., Arrese M., Bataller R., Berg T., Brennan P. N., Burra P., Castro-Narro G. E., Cortez-Pinto H., Cusi K., Dedes N., Duseja A., Francque S. M., Hagstrom H., Huang T. T. -K., Wajcman D. I., Kautz A., Kopka C. J., Krag A., Miller V., Newsome P. N., Rinella M. E., Romero D., Sarin S. K., Silva M., Spearman C. W., Tsochatzis E. A., Valenti L., Villota-Rivas M., Zelber-Sagi S., Schattenberg J. M., Wong V. W. -S., Younossi Z. M., Aberg F., Adams L., Al-Naamani K., Albadawy R. M., Alexa Z., Allison M., Alnaser F. A., Alswat K., Alvares-da-Silva M. R., Alvaro D., Alves-Bezerra M., Andrade R. J., Anstee Q. M., Awuku Y. A., Baatarkhuu O., Baffy G., Bakieva S., Bansal M. B., Barouki R., Batterham R. L., Behling C., Belfort-DeAguiar R., Berzigotti A., Betel M., Bianco C., Bosi E., Boursier J., Brunt E. M., Bugianesi E., Byrne C. J., Cabrera Cabrejos M. C., Caldwell S., Carr R., Castellanos Fernandez M. I., Castera L., Castillo-Lopez M. G., Caussy C., Cerda-Reyes E., Ceriello A., Chan W. -K., Chang Y., Charatcharoenwitthaya P., Chavez-Tapia N., Chung R. T., Colombo M., Coppell K., Cotrim H. P., Craxi A., Crespo J., Dassanayake A., Davidson N. O., De Knegt R., de Ledinghen V., Demir M., Desalegn H., Diago M., Dillon J. F., Dimmig B., Dirac M. A., Dirchwolf M., Dufour J. -F., Dvorak K., Ekstedt M., El-Kassas M., Elsanousi O. M., Elsharkawy A. M., Elwakil R., Eskridge W., Eslam M., Esmat G., Fan J. -G., Ferraz M. L., Flisiak R., Fortin D., Fouad Y., Freidman S. L., Fuchs M., Gadano A., Gastaldelli A., Geerts A., Geier A., George J., Gerber L. H., Ghazinyan H., Gheorghe L., Kile D. G., Girala M., Boon Bee G. G., Goossens N., Graupera I., Gronbaek H., Hamid S., Hebditch V., Henry Z., Hickman I. J., Hobbs L. A., Hocking S. L., Hofmann W. P., Idilman R., Iruzubieta P., Isaacs S., Isakov V. A., Ismail M. H., Jamal M. H., Jarvis H., Jepsen P., Jornayvaz F., Sudhamshu K. C., Kakizaki S., Karpen S., Kawaguchi T., Keating S. E., Khader Y., Kim S. U., Kim W., Kleiner D. E., Koek G., Joseph Komas N. P., Kondili L. A., Koot B. G., Korenjak M., Kotsiliti E., Koulla Y., Kugelmas C., Kugelmas M., Labidi A., Lange N. F., Lavine J. E., Lazo M., Leite N., Lin H. -C., Lkhagvaa U., Long M. T., Lopez-Jaramillo P., Lozano A., Macedo M. P., Malekzadeh R., Marchesini G., Marciano S., Martinez K., Martinez Vazquez S. E., Mateva L., Mato J. M., Nlombi C. M., McCary A. G., McIntyre J., McKee M., Mendive J. M., Mikolasevic I., Miller P. S., Milovanovic T., Milton T., Moreno-Alcantar R., Morgan T. R., Motala A., Muris J., Musso C., Nava-Gonzalez E. J., Negro F., Nersesov A. V., Neuschwander-Tetri B. A., Nikolova D., Norris S., Novak K., Ocama P., Ong J. P., Ong-Go A., Onyekwere C., Padilla M., Pais R., Pan C., Panduro A., Panigrahi M. K., Papatheodoridis G., Paruk I., Patel K., Goncalves C. P., Figueroa M. P., Perez-Escobar J., Pericas J. M., Perseghin G., Pessoa M. G., Petta S., Marques Souza de Oliveira C. P., Prabhakaran D., Pyrsopoulous N., Rabiee A., Ramji A., Ratziu V., Ravendhran N., Ray K., Roden M., Romeo S., Romero-Gomez M., Rotman Y., Rouabhia S., Rowe I. A., Sadirova S., Alkhatry M. S., Salupere R., Satapathy S. K., Schwimmer J. B., Sebastiani G., Seim L., Seki Y., Serme A. K., Shapiro D., Sharvadze L., Shaw J. E., Shawa I. T., Shenoy T., Shibolet O., Shimakawa Y., Shubrook J. H., Singh S. P., Sinkala E., Skladany L., Skrypnyk I., Song M. J., Sookoian S., Sridharan K., Stefan N., Stine J. G., Stratakis N., Sheriff D. S., Sundaram S. S., Svegliati-Baroni G., Swain M. G., Tacke F., Taheri S., Tan S. -S., Tapper E. B., Targher G., Tcaciuc E., Thiele M., Tiniakos D., Tolmane I., Torre A., Torres E. A., Treeprasertsuk S., Trenell M., Turcan S., Turcanu A., Valantinas J., van Kleef L. A., Velarde Ruiz Velasco J. A., Vesterhus M., Vilar-Gomez E., Waked I., Wattacheril J., Wedemeyer H., Wilkins F., Willemse J., Wong R. J., Yilmaz Y., Yki-Jarvinen H., Yu M. -L., Yumuk V., Zeybel M., Zheng K. I., Zheng M. -H., Lazarus, J, Mark, H, Allen, A, Arab, J, Carrieri, P, Noureddin, M, Alazawi, W, Alkhouri, N, Alqahtani, S, Arrese, M, Bataller, R, Berg, T, Brennan, P, Burra, P, Castro-Narro, G, Cortez-Pinto, H, Cusi, K, Dedes, N, Duseja, A, Francque, S, Hagstrom, H, Huang, T, Wajcman, D, Kautz, A, Kopka, C, Krag, A, Miller, V, Newsome, P, Rinella, M, Romero, D, Sarin, S, Silva, M, Spearman, C, Tsochatzis, E, Valenti, L, Villota-Rivas, M, Zelber-Sagi, S, Schattenberg, J, Wong, V, Younossi, Z, Aberg, F, Adams, L, Al-Naamani, K, Albadawy, R, Alexa, Z, Allison, M, Alnaser, F, Alswat, K, Alvares-da-Silva, M, Alvaro, D, Alves-Bezerra, M, Andrade, R, Anstee, Q, Awuku, Y, Baatarkhuu, O, Baffy, G, Bakieva, S, Bansal, M, Barouki, R, Batterham, R, Behling, C, Belfort-DeAguiar, R, Berzigotti, A, Betel, M, Bianco, C, Bosi, E, Boursier, J, Brunt, E, Bugianesi, E, Byrne, C, Cabrera Cabrejos, M, Caldwell, S, Carr, R, Castellanos Fernandez, M, Castera, L, Castillo-Lopez, M, Caussy, C, Cerda-Reyes, E, Ceriello, A, Chan, W, Chang, Y, Charatcharoenwitthaya, P, Chavez-Tapia, N, Chung, R, Colombo, M, Coppell, K, Cotrim, H, Craxi, A, Crespo, J, Dassanayake, A, Davidson, N, De Knegt, R, de Ledinghen, V, Demir, M, Desalegn, H, Diago, M, Dillon, J, Dimmig, B, Dirac, M, Dirchwolf, M, Dufour, J, Dvorak, K, Ekstedt, M, El-Kassas, M, Elsanousi, O, Elsharkawy, A, Elwakil, R, Eskridge, W, Eslam, M, Esmat, G, Fan, J, Ferraz, M, Flisiak, R, Fortin, D, Fouad, Y, Freidman, S, Fuchs, M, Gadano, A, Gastaldelli, A, Geerts, A, Geier, A, George, J, Gerber, L, Ghazinyan, H, Gheorghe, L, Kile, D, Girala, M, Boon Bee, G, Goossens, N, Graupera, I, Gronbaek, H, Hamid, S, Hebditch, V, Henry, Z, Hickman, I, Hobbs, L, Hocking, S, Hofmann, W, Idilman, R, Iruzubieta, P, Isaacs, S, Isakov, V, Ismail, M, Jamal, M, Jarvis, H, Jepsen, P, Jornayvaz, F, Sudhamshu, K, Kakizaki, S, Karpen, S, Kawaguchi, T, Keating, S, Khader, Y, Kim, S, Kim, W, Kleiner, D, Koek, G, Joseph Komas, N, Kondili, L, Koot, B, Korenjak, M, Kotsiliti, E, Koulla, Y, Kugelmas, C, Kugelmas, M, Labidi, A, Lange, N, Lavine, J, Lazo, M, Leite, N, Lin, H, Lkhagvaa, U, Long, M, Lopez-Jaramillo, P, Lozano, A, Macedo, M, Malekzadeh, R, Marchesini, G, Marciano, S, Martinez, K, Martinez Vazquez, S, Mateva, L, Mato, J, Nlombi, C, Mccary, A, Mcintyre, J, Mckee, M, Mendive, J, Mikolasevic, I, Miller, P, Milovanovic, T, Milton, T, Moreno-Alcantar, R, Morgan, T, Motala, A, Muris, J, Musso, C, Nava-Gonzalez, E, Negro, F, Nersesov, A, Neuschwander-Tetri, B, Nikolova, D, Norris, S, Novak, K, Ocama, P, Ong, J, Ong-Go, A, Onyekwere, C, Padilla, M, Pais, R, Pan, C, Panduro, A, Panigrahi, M, Papatheodoridis, G, Paruk, I, Patel, K, Goncalves, C, Figueroa, M, Perez-Escobar, J, Pericas, J, Perseghin, G, Pessoa, M, Petta, S, Marques Souza de Oliveira, C, Prabhakaran, D, Pyrsopoulous, N, Rabiee, A, Ramji, A, Ratziu, V, Ravendhran, N, Ray, K, Roden, M, Romeo, S, Romero-Gomez, M, Rotman, Y, Rouabhia, S, Rowe, I, Sadirova, S, Alkhatry, M, Salupere, R, Satapathy, S, Schwimmer, J, Sebastiani, G, Seim, L, Seki, Y, Serme, A, Shapiro, D, Sharvadze, L, Shaw, J, Shawa, I, Shenoy, T, Shibolet, O, Shimakawa, Y, Shubrook, J, Singh, S, Sinkala, E, Skladany, L, Skrypnyk, I, Song, M, Sookoian, S, Sridharan, K, Stefan, N, Stine, J, Stratakis, N, Sheriff, D, Sundaram, S, Svegliati-Baroni, G, Swain, M, Tacke, F, Taheri, S, Tan, S, Tapper, E, Targher, G, Tcaciuc, E, Thiele, M, Tiniakos, D, Tolmane, I, Torre, A, Torres, E, Treeprasertsuk, S, Trenell, M, Turcan, S, Turcanu, A, Valantinas, J, van Kleef, L, Velarde Ruiz Velasco, J, Vesterhus, M, Vilar-Gomez, E, Waked, I, Wattacheril, J, Wedemeyer, H, Wilkins, F, Willemse, J, Wong, R, Yilmaz, Y, Yki-Jarvinen, H, Yu, M, Yumuk, V, Zeybel, M, Zheng, K, Zheng, M, Lazarus J. V., Mark H. E., Allen A. M., Arab J. P., Carrieri P., Noureddin M., Alazawi W., Alkhouri N., Alqahtani S. A., Arrese M., Bataller R., Berg T., Brennan P. N., Burra P., Castro-Narro G. E., Cortez-Pinto H., Cusi K., Dedes N., Duseja A., Francque S. M., Hagstrom H., Huang T. T. -K., Wajcman D. I., Kautz A., Kopka C. J., Krag A., Miller V., Newsome P. N., Rinella M. E., Romero D., Sarin S. K., Silva M., Spearman C. W., Tsochatzis E. A., Valenti L., Villota-Rivas M., Zelber-Sagi S., Schattenberg J. M., Wong V. W. -S., Younossi Z. M., Aberg F., Adams L., Al-Naamani K., Albadawy R. M., Alexa Z., Allison M., Alnaser F. A., Alswat K., Alvares-da-Silva M. R., Alvaro D., Alves-Bezerra M., Andrade R. J., Anstee Q. M., Awuku Y. A., Baatarkhuu O., Baffy G., Bakieva S., Bansal M. B., Barouki R., Batterham R. L., Behling C., Belfort-DeAguiar R., Berzigotti A., Betel M., Bianco C., Bosi E., Boursier J., Brunt E. M., Bugianesi E., Byrne C. J., Cabrera Cabrejos M. C., Caldwell S., Carr R., Castellanos Fernandez M. I., Castera L., Castillo-Lopez M. G., Caussy C., Cerda-Reyes E., Ceriello A., Chan W. -K., Chang Y., Charatcharoenwitthaya P., Chavez-Tapia N., Chung R. T., Colombo M., Coppell K., Cotrim H. P., Craxi A., Crespo J., Dassanayake A., Davidson N. O., De Knegt R., de Ledinghen V., Demir M., Desalegn H., Diago M., Dillon J. F., Dimmig B., Dirac M. A., Dirchwolf M., Dufour J. -F., Dvorak K., Ekstedt M., El-Kassas M., Elsanousi O. M., Elsharkawy A. M., Elwakil R., Eskridge W., Eslam M., Esmat G., Fan J. -G., Ferraz M. L., Flisiak R., Fortin D., Fouad Y., Freidman S. L., Fuchs M., Gadano A., Gastaldelli A., Geerts A., Geier A., George J., Gerber L. H., Ghazinyan H., Gheorghe L., Kile D. G., Girala M., Boon Bee G. G., Goossens N., Graupera I., Gronbaek H., Hamid S., Hebditch V., Henry Z., Hickman I. J., Hobbs L. A., Hocking S. L., Hofmann W. P., Idilman R., Iruzubieta P., Isaacs S., Isakov V. A., Ismail M. H., Jamal M. H., Jarvis H., Jepsen P., Jornayvaz F., Sudhamshu K. C., Kakizaki S., Karpen S., Kawaguchi T., Keating S. E., Khader Y., Kim S. U., Kim W., Kleiner D. E., Koek G., Joseph Komas N. P., Kondili L. A., Koot B. G., Korenjak M., Kotsiliti E., Koulla Y., Kugelmas C., Kugelmas M., Labidi A., Lange N. F., Lavine J. E., Lazo M., Leite N., Lin H. -C., Lkhagvaa U., Long M. T., Lopez-Jaramillo P., Lozano A., Macedo M. P., Malekzadeh R., Marchesini G., Marciano S., Martinez K., Martinez Vazquez S. E., Mateva L., Mato J. M., Nlombi C. M., McCary A. G., McIntyre J., McKee M., Mendive J. M., Mikolasevic I., Miller P. S., Milovanovic T., Milton T., Moreno-Alcantar R., Morgan T. R., Motala A., Muris J., Musso C., Nava-Gonzalez E. J., Negro F., Nersesov A. V., Neuschwander-Tetri B. A., Nikolova D., Norris S., Novak K., Ocama P., Ong J. P., Ong-Go A., Onyekwere C., Padilla M., Pais R., Pan C., Panduro A., Panigrahi M. K., Papatheodoridis G., Paruk I., Patel K., Goncalves C. P., Figueroa M. P., Perez-Escobar J., Pericas J. M., Perseghin G., Pessoa M. G., Petta S., Marques Souza de Oliveira C. P., Prabhakaran D., Pyrsopoulous N., Rabiee A., Ramji A., Ratziu V., Ravendhran N., Ray K., Roden M., Romeo S., Romero-Gomez M., Rotman Y., Rouabhia S., Rowe I. A., Sadirova S., Alkhatry M. S., Salupere R., Satapathy S. K., Schwimmer J. B., Sebastiani G., Seim L., Seki Y., Serme A. K., Shapiro D., Sharvadze L., Shaw J. E., Shawa I. T., Shenoy T., Shibolet O., Shimakawa Y., Shubrook J. H., Singh S. P., Sinkala E., Skladany L., Skrypnyk I., Song M. J., Sookoian S., Sridharan K., Stefan N., Stine J. G., Stratakis N., Sheriff D. S., Sundaram S. S., Svegliati-Baroni G., Swain M. G., Tacke F., Taheri S., Tan S. -S., Tapper E. B., Targher G., Tcaciuc E., Thiele M., Tiniakos D., Tolmane I., Torre A., Torres E. A., Treeprasertsuk S., Trenell M., Turcan S., Turcanu A., Valantinas J., van Kleef L. A., Velarde Ruiz Velasco J. A., Vesterhus M., Vilar-Gomez E., Waked I., Wattacheril J., Wedemeyer H., Wilkins F., Willemse J., Wong R. J., Yilmaz Y., Yki-Jarvinen H., Yu M. -L., Yumuk V., Zeybel M., Zheng K. I., and Zheng M. -H.

Abstract

Background & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. Methods: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. Results: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of ‘agree’ responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement (‘agree’ + ‘somewhat agree’); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% ‘agree’), 13 priorities had [removed]90% combined agreement. Conclusions: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community's efforts to advance and accelerate responses to this widespread and fast-growing public health threat. Impact and implications: An estimated 38% of adults and 13% o

Published
2023

11. S1P content as a characteristic of the cardioprotective properties of HDL in coronary heart disease and diabetes mellitus

Author

Polzin, A M I N, primary, Benkhoff, M A R C E L, additional, Dannenberg, L I S A, additional, Barcik, M A I K E, additional, Schroeder, N A T A L I, additional, Weske, S A R A H, additional, Vogt, J E N S, additional, Wolnitzke, P H I L I P, additional, Mourikis, P H I L I P, additional, Keul, P E T R A, additional, Sarabhai, T H E R E S, additional, Zeus, T O B I A S, additional, Roden, M I C H A E, additional, Kelm, M A L T E, additional, and Levkau, B O D O, additional

Published
2023
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15. Association of thyroid function with non‐alcoholic fatty liver disease in recent‐onset diabetes.

Author

Saatmann, Nina, Schön, Martin, Zaharia, Oana‐Patricia, Huttasch, Maximilian, Strassburger, Klaus, Trenkamp, Sandra, Kupriyanova, Yuliya, Schrauwen‐Hinderling, Vera, Kahl, Sabine, Burkart, Volker, Wagner, Robert, Roden, Michael, Roden, M., Al‐Hasani, H., Belgardt, B. F., Bönhof, G., Geerling, G., Herder, C., Icks, A., and Jandeleit‐Dahm, K.

Subjects
NON-alcoholic fatty liver disease, FATTY liver, TYPE 1 diabetes, TYPE 2 diabetes, DIABETES, THYROID gland
Abstract

Background and Aims: Non‐alcoholic fatty liver disease (NAFLD) has been linked to type 2 diabetes (T2D), but also to hypothyroidism. Nevertheless, the relationship between thyroid function and NAFLD in diabetes is less clear. This study investigated associations between free thyroxine (fT4) or thyroid‐stimulating hormone (TSH) and NAFLD in recent‐onset diabetes. Methods: Participants with recent‐onset type 1 diabetes (T1D, n = 358), T2D (n = 596) or without diabetes (CON, n = 175) of the German Diabetes Study (GDS), a prospective longitudinal cohort study, underwent Botnia clamp tests and assessment of fT4, TSH, fatty liver index (FLI) and in a representative subcohort 1H‐magnetic resonance spectroscopy. Results: First, fT4 levels were similar between T1D and T2D (p =.55), but higher than in CON (T1D: p <.01; T2D: p <.001), while TSH concentrations were not different between all groups. Next, fT4 correlated negatively with FLI and positively with insulin sensitivity only in T2D (ß = −.110, p <.01; ß =.126, p <.05), specifically in males (ß = −.117, p <.05; ß =.162; p <.01) upon adjustments for age, sex and BMI. However, correlations between fT4 and FLI lost statistical significance after adjustment for insulin sensitivity (T2D: ß = −.021, p = 0.67; males with T2D: ß = −.033; p =.56). TSH was associated positively with FLI only in male T2D before (ß =.116, p <.05), but not after adjustments for age and BMI (ß =.052; p =.30). Conclusions: Steatosis risk correlates with lower thyroid function in T2D, which is mediated by insulin resistance and body mass, specifically in men, whereas no such relationship is present in T1D. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Loci for insulin processing and secretion provide insight into type 2 diabetes risk

Author

Broadaway, K. A. (K. Alaine), Yin, X. (Xianyong), Williamson, A. (Alice), Parsons, V. A. (Victoria A.), Wilson, E. P. (Emma P.), Moxley, A. H. (Anne H.), Vadlamudi, S. (Swarooparani), Varshney, A. (Arushi), Jackson, A. U. (Anne U.), Ahuja, V. (Vasudha), Bornstein, S. R. (Stefan R.), Corbin, L. J. (Laura J.), Delgado, G. E. (Graciela E.), Dwivedi, O. P. (Om P.), Silva, L. F. (Lilian Fernandes), Frayling, T. M. (Timothy M.), Grallert, H. (Harald), Gustafsson, S. (Stefan), Hakaste, L. (Liisa), Hammar, U. (Ulf), Herder, C. (Christian), Herrmann, S. (Sandra), Hojlund, K. (Kurt), Hughes, D. A. (David A.), Kleber, M. E. (Marcus E.), Lindgren, C. M. (Cecilia M.), Liu, C.-T. (Ching-Ti), Luan, J. (Jian'an), Malmberg, A. (Anni), Moissl, A. P. (Angela P.), Morris, A. P. (Andrew P.), Perakakis, N. (Nikolaos), Peters, A. (Annette), Petrie, J. R. (John R.), Roden, M. (Michael), Schwarz, P. E. (Peter E. H.), Sharma, S. (Sapna), Silveira, A. (Angela), Strawbridge, R. J. (Rona J.), Tuomi, T. (Tiinamaija), Wood, A. R. (Andrew R.), Wu, P. (Peitao), Zethelius, B. (Bjorn), Baldassarre, D. (Damiano), Eriksson, J. G. (Johan G.), Fall, T. (Tove), Florez, J. C. (Jose C.), Fritsche, A. (Andreas), Gigante, B. (Bruna), Hamsten, A. (Anders), Kajantie, E. (Eero), Laakso, M. (Markku), Lahti, J. (Jari), Lawlor, D. A. (Deborah A.), Lind, L. (Lars), Maerz, W. (Winfried), Meigs, J. B. (James B.), Sundstrom, J. (Johan), Timpson, N. J. (Nicholas J.), Wagner, R. (Robert), Walker, M. (Mark), Wareham, N. J. (Nicholas J.), Watkins, H. (Hugh), Barroso, I. (Ines), O'Rahilly, S. (Stephen), Grarup, N. (Niels), Parker, S. C. (Stephen CJ.), Boehnke, M. (Michael), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), Mohlke, K. L. (Karen L.), Broadaway, K. A. (K. Alaine), Yin, X. (Xianyong), Williamson, A. (Alice), Parsons, V. A. (Victoria A.), Wilson, E. P. (Emma P.), Moxley, A. H. (Anne H.), Vadlamudi, S. (Swarooparani), Varshney, A. (Arushi), Jackson, A. U. (Anne U.), Ahuja, V. (Vasudha), Bornstein, S. R. (Stefan R.), Corbin, L. J. (Laura J.), Delgado, G. E. (Graciela E.), Dwivedi, O. P. (Om P.), Silva, L. F. (Lilian Fernandes), Frayling, T. M. (Timothy M.), Grallert, H. (Harald), Gustafsson, S. (Stefan), Hakaste, L. (Liisa), Hammar, U. (Ulf), Herder, C. (Christian), Herrmann, S. (Sandra), Hojlund, K. (Kurt), Hughes, D. A. (David A.), Kleber, M. E. (Marcus E.), Lindgren, C. M. (Cecilia M.), Liu, C.-T. (Ching-Ti), Luan, J. (Jian'an), Malmberg, A. (Anni), Moissl, A. P. (Angela P.), Morris, A. P. (Andrew P.), Perakakis, N. (Nikolaos), Peters, A. (Annette), Petrie, J. R. (John R.), Roden, M. (Michael), Schwarz, P. E. (Peter E. H.), Sharma, S. (Sapna), Silveira, A. (Angela), Strawbridge, R. J. (Rona J.), Tuomi, T. (Tiinamaija), Wood, A. R. (Andrew R.), Wu, P. (Peitao), Zethelius, B. (Bjorn), Baldassarre, D. (Damiano), Eriksson, J. G. (Johan G.), Fall, T. (Tove), Florez, J. C. (Jose C.), Fritsche, A. (Andreas), Gigante, B. (Bruna), Hamsten, A. (Anders), Kajantie, E. (Eero), Laakso, M. (Markku), Lahti, J. (Jari), Lawlor, D. A. (Deborah A.), Lind, L. (Lars), Maerz, W. (Winfried), Meigs, J. B. (James B.), Sundstrom, J. (Johan), Timpson, N. J. (Nicholas J.), Wagner, R. (Robert), Walker, M. (Mark), Wareham, N. J. (Nicholas J.), Watkins, H. (Hugh), Barroso, I. (Ines), O'Rahilly, S. (Stephen), Grarup, N. (Niels), Parker, S. C. (Stephen CJ.), Boehnke, M. (Michael), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), and Mohlke, K. L. (Karen L.)

Abstract

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. We conducted meta-analyses of genome-wide association results for fasting proinsulin from 16 European-ancestry studies in 45,861 individuals. We found 36 independent signals at 30 loci (p value <5×10⁻⁸), which validated 12 previously reported loci for proinsulin and ten additional loci previously identified for another glycemic trait. Half of the alleles associated with higher proinsulin showed higher rather than lower effects on glucose levels, corresponding to different mechanisms. Proinsulin loci included genes that affect prohormone convertases, beta-cell dysfunction, vesicle trafficking, beta-cell transcriptional regulation, and lysosomes/autophagy processes. We colocalized 11 proinsulin signals with islet expression quantitative trait locus (eQTL) data, suggesting candidate genes, including ARSG, WIPI1, SLC7A14, and SIX3. The NKX6‐3/ANK1 proinsulin signal colocalized with a T2D signal and an adipose ANK1 eQTL signal but not the islet NKX6‐3 eQTL. Signals were enriched for islet enhancers, and we showed a plausible islet regulatory mechanism for the lead signal in the MADD locus. These results show how detailed genetic studies of an intermediate phenotype can elucidate mechanisms that may predispose one to disease.

Published
2023

18. Synthesis and characterisation of some novel low-coordinate phosphorus compounds containing bulky electron-withdrawing substituents

Author

Roden, M. D.

Subjects
546, Platinum compounds
Abstract

The synthesis of several new phosphorus derivatives including new monophosphanes of the type RPX(_2) (X = F, CI and H), containing either the Fluoromes [2,4,6-(CF(_3))(_3)C(_6)H(_2)] or Fluoroxyl [2,6-(CF(_3))(_2)C(_6)H(_3)] group has been carried out successfully. The synthesis of a number of Cis-Platin analogous has been facilitated by the reaction of these new monophosphanes with a platinum dimer [(PCl(_2)(Pet(_3))(_2)](_2). These compounds are of the type PtCl(_2)(Pet(_3))RPX(_2) (X = CI, H and F, R = 2,6- bis(trifluoromethyl)phenyl). These compounds have shown an interesting correlation between bond length and (^1)J(_p-pt) NMR coupling. Disubstituted phosphanes (RPX(_2), X = CI, H) have also been synthesised and subsequent reaction has facilitated the formation, characterisation and structure solution of a new phosphorus (I) species (RP(_2)(^(-)))(Ph(_3)PCH(_3))(^1) (R - Fluoromes).Attempts have been made to synthesise the first phosphaalkyne containing a bulky electron withdrawing ligand. This involved the reaction of RP=CCl(_2) (R = 2,6- bis(trifluoromethyl)phenyl) with a number of Pt(0) and Pd(0) species. (^31)P NMR studies have been used extensively throughout the project to help characterise and identify the products. The single crystal, solid state structures of many of the new species were elucidated by X-ray diffraction using a Siemens Smart CCD.

Published
1998

19. Typ-2-Diabetes

Author

Ammon, H. P. T., Burchard, A., Drexel, H., Füchtenbusch, M., Häring, H.-U., Hauner, H., Joost, H.-G., Matthaei, S., Merkel, M., Müller-Wieland, D., Pfohl, M., Roden, M., Rustenbeck, I., Säly, C., Schatz, H., Schifferdecker, E., Schinner, S., Schwarz, P., Szendrödi, J., Vonbank, A., Wascher, T., Zeyfang, A., Schatz, Helmut, editor, and Pfeiffer, Andreas F. H., editor

Published
2014
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20. A global initiative to deliver precision health in diabetes

Author

Cefalu, W. T., Franks, P. W., Rosenblum, N. D., Zaghloul, N. A., Florez, J. C., Giorgino, F., Ji, L., Ma, R. C. W., Mathieu, C., Misra, S., Ramirez, A. H., Roden, M., Scherer, P. E., Sheu, W. H. -H., Stehouwer, C. D. A., Woo, M., Pragnell, M., Anand, S. S., Carnethon, M., Chambers, J. C., Dennis, J. M., Gloyn, A. L., Herder, C., Holt, R. I. G., Manuel, D. G., Redondo, M. J., Tandon, N., Tsang, J. S., Udler, M. S., and Rich, S. S.

Abstract

A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.

Published
2024
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21. Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes.

Author

Schön, Martin, Zaharia, Oana P., Strassburger, Klaus, Kupriyanova, Yuliya, Bódis, Kálmán, Heilmann, Geronimo, Strom, Alexander, Bönhof, Gidon J., Michelotti, Filippo, Yurchenko, Iryna, Möser, Clara, Huttasch, Maximilian, Bombrich, Maria, Kelm, Malte, Burkart, Volker, Schrauwen-Hinderling, Vera B., Wagner, Robert, Roden, Michael, GDS Group, and Roden, M.

Subjects
GLUCOSE clamp technique, TYPE 1 diabetes, TYPE 2 diabetes, DISEASE risk factors, INSULIN sensitivity, PHYSICAL fitness, HYPERGLYCEMIA
Abstract

Intramyocellular lipid content (IMCL) is elevated in insulin-resistant humans, but it changes over time, and relationships with comorbidities remain unclear. We examined IMCL during the initial course of diabetes and its associations with complications. Participants of the German Diabetes Study (GDS) with recent-onset type 1 (n = 132) or type 2 diabetes (n = 139) and glucose-tolerant control subjects (n = 128) underwent 1H-MRS to measure IMCL and muscle volume, whole-body insulin sensitivity (hyperinsulinemic-euglycemic clamps; M-value), and cycling spiroergometry (VO2max). Subgroups underwent the same measurements after 5 years. At baseline, IMCL was ∼30% higher in type 2 diabetes than in other groups independently of age, sex, BMI, and muscle volume. In type 2 diabetes, the M-value was ∼36% and ∼62% lower compared with type 1 diabetes and control subjects, respectively. After 5 years, the M-value decreased by ∼29% in type 1 and ∼13% in type 2 diabetes, whereas IMCL remained unchanged. The correlation between IMCL and M-value in type 2 diabetes at baseline was modulated by VO2max. IMCL also associated with microalbuminuria, the Framingham risk score for cardiovascular disease, and cardiac autonomic neuropathy. Changes in IMCL within 5 years after diagnosis do not mirror the progression of insulin resistance in type 2 diabetes but associate with early diabetes-related complications. Article Highlights: Intramyocellular lipid content (IMCL) can be elevated in insulin-resistant humans, but its dynamics and association with comorbidities remain unclear. Independently of age, sex, body mass, and skeletal muscle volume, IMCL is higher in recent-onset type 2, but not type 1 diabetes, and remains unchanged within 5 years, despite worsening insulin resistance. A degree of physical fitness modulates the association between IMCL and insulin sensitivity in type 2 diabetes. Whereas higher IMCL associates with lower insulin sensitivity in people with lower physical fitness, there is no association between IMCL and insulin sensitivity in those with higher degree of physical fitness. IMCL associates with progression of microalbuminuria, cardiovascular disease risk, and cardiac autonomic neuropathy. [ABSTRACT FROM AUTHOR]

Published
2023
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22. SYSTEMI - Systemic organ communication in STEMI: Design and rationale of a cohort study of patients with ST-segment elevation myocardial infarction

Author

Bönner, F, primary, Jung, C, additional, Polzin, A, additional, Erkens, R, additional, Dannenberg, L, additional, Ipek, R, additional, Kaldirim, M, additional, Cramer, M, additional, Wischmann, P, additional, Zaharia, O-P, additional, Meyer, C, additional, Flögel, U, additional, Levkau, B, additional, Gödecke, A, additional, Fischer, JW, additional, Klöcker, N, additional, Krüger, M, additional, Roden, M, additional, and Kelm, M, additional

Published
2023
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24. Komorbiditäten

Author

Wirth, A., Hauner, H., Roden, M., Parhofer, K., May, M., Engeli, St., Jordan, J., Schulz, R., Schneider, K.T.M., Grote, V.A., Teucher, B., Kaaks, R., Wirth, Alfred, editor, and Hauner, Hans, editor

Published
2013
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27. Impaired Cardioprotection by HDL in CAD and Diabetes in Ischemia/Reperfusion Injury: role of S1P and SR-BI

Author

Polzin, A, primary, Dannenberg, L, additional, Schroeder, N, additional, Benkhoff, M, additional, Vogt, J, additional, Keul, P, additional, Weske, S, additional, Sarabhai, T, additional, Zeus, T, additional, Mueller, T, additional, Wolnitzke, P, additional, Graele, M, additional, Roden, M, additional, Kelm, M, additional, and Levkau, B, additional

Published
2022
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28. Absolute treatment effects of novel oral antidiabetic drugs on cardiovascular mortality and hospitalization for heart failure: a meta-analysis of digitalized individual patient outcomes

Author

Wolff, G, primary, Lin, Y, additional, Akbulut, C, additional, Brockmeyer, M, additional, Parco, C, additional, Hoss, A, additional, Sokolowski, A, additional, Westenfeld, R, additional, Kelm, M, additional, Roden, M, additional, Schlesinger, S, additional, and Kuss, O, additional

Published
2022
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32. Development of CMR-derived aortic stiffness parameters in patients with metabolic comorbidities after ST-segment elevation myocardial infarction

Author

Marjani, K, primary, Erkens, R, additional, Kramser, N, additional, Ipek, R, additional, Nienhaus, F, additional, Haberkorn, W, additional, Wischmann, P, additional, Polzin, A, additional, Roden, M, additional, Jung, C, additional, Kelm, M, additional, Boenner, F, additional, and Cramer, M, additional

Published
2022
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34. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes

Author

Apostolopoulou, Maria, Strassburger, Klaus, Herder, Christian, Knebel, Birgit, Kotzka, Jörg, Szendroedi, Julia, Roden, Michael, Roden, M., Buyken, A. E., Eckel, J., Geerling, G., Al-Hasani, H., Herder, C., Icks, A., Kotzka, J., Kuss, O., Lammert, E., Lundbom, J., Müssig, K., Nowotny, P., Rathmann, W., Szendroedi, J., Ziegler, D., and for the GDS group

Published
2016
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38. Advancing the global public health agenda for NAFLD: a consensus statement

Author

Lazarus, J.V. Mark, H.E. Anstee, Q.M. Arab, J.P. Batterham, R.L. Castera, L. Cortez-Pinto, H. Crespo, J. Cusi, K. Dirac, M.A. Francque, S. George, J. Hagström, H. Huang, T.T.-K. Ismail, M.H. Kautz, A. Sarin, S.K. Loomba, R. Miller, V. Newsome, P.N. Ninburg, M. Ocama, P. Ratziu, V. Rinella, M. Romero, D. Romero-Gómez, M. Schattenberg, J.M. Tsochatzis, E.A. Valenti, L. Wong, V.W.-S. Yilmaz, Y. Younossi, Z.M. Zelber-Sagi, S. Åberg, F. Adams, L. Khatry, M.S.A. Naamani, K.A. Murillo, O.A. Allen, A.M. Alnaser, F. Alqahtani, S.A. Alswat, K. Alvaro, D. Andrade, R.J. Arrese, M. Awuku, Y.A. Ayesha, M. Baatarkhuu, O. Bakieva, S. Basu, R. Bataller, R. Bedri, S. Bosi, E. Bourliere, M. Bruha, R. Bugianesi, E. Burra, P. Buti, M. Byrne, C.D. Calleja, J.L. Carrieri, P. Carter, F. Fernandez, M.I.C. Castillo-Lopez, G. Castro-Narro, G.E. Chan, H.L.Y. Chan, W.-K. Chang, Y. Colombo, M. Coppell, K.J. Corey, K. Craxi, A. Cryer, D. Dassanayake, A. Martins, A.A.S. de Ledinghen, V. DelPrato, S. Demaio, A. Desalegn, H. Dillon, J. Duseja, A. Dorairaj, P. Ekstedt, M. El Kassas, M. Elsanousi, O.M. Esmat, G. Fan, J.-G. Farpour-Lambert, N. Flisiak, R. Fouad, Y. Fuchs, M. Gani, R.A. Gerber, L. Ghazinyan, H. Gheorghe, L. Goh, G.B.-B. Grønbæk, H. Gulnara, A. Hamid, S. Hebditch, V. Hickman, I.J. Hocking, S.L. Hunyady, B. Idilman, R. Isakov, V.A. Jamal, M.H. Jepsen, P. Iskandar, N.J. Song, M.J. Sudhamshu, K.C. Kakizaki, S. Kalamitsis, G. Kanwal, F. Kao, J.-H. Kaplan, L. Kawaguchi, T. Khader, Y. Kim, S.U. Kodjoh, N. Koek, G. Koike, K. Komas, N.P. Korenjak, M. Kugelmas, M. Labidi, A. Lange, N.F. Lavine, J.E. Lazo, M. Lee, N. Lesmana, C.R.A. Liu, C.-J. Long, M.T. Lopez-Jaramillo, P. Malekzadeh, R. Mahtab, M.A. Marchesini, G. Marinho, R. Vázquez, S.E.M. Mateva, L. Nlombi, C.M. Melin, P. Mikolasevic, I. Milovanovic, T. Musso, C. Nakajima, A. Nava, E. Nersesov, A.V. Nikolova, D. Norris, S. Novak, K. Oben, J. Ong, J.P. Onyekwere, C. Papatheodoridis, G. Paruk, I. Patel, K. Macedo, M.P. Penha-Gonçalves, C. Figueroa, M.P. Hofmann, W.P. Petta, S. de Oliveira, C.P.M.S. Puri, P. Pan, C.Q. Rac, M. Ralston, J. Ramji, A. Razavi, H. Alvares-da-Silva, M.R. Roberts, S. Roden, M. Rose, T. Rouabhia, S. Rovere-Querini, P. Rowe, I.A. Sadirova, S. Salupere, R. Saparbu, T. Sayegh, R. Sebastiani, G. Seki, Y. Selmo, J. Serme, A.K. Shaw, J.E. Shenoy, T. Sheron, N. Shibolet, O. Silva, M. Skrypnyk, I. Socha, P. Soriano, J. Spearman, C.W. Sridharan, K. Suárez, J.J. Sheriff, D.S. Sung, K.-C. Swain, M. Tacke, F. Taheri, S. Tan, S.-S. Tapper, E.B. Yki-Järvinen, H. Thiele, M. Shawa, I.T. Tolmane, I. Torres, E.A. Trauner, M. Treeprasertsuk, S. Turcanu, A. Valantinas, J. Vesterhus, M. Waked, I. Wild, S.H. Willemse, J. Wong, R.J. Xanthakos, S. Young, D.Y. Yu, M.-L. Zheng, K.I. Zeybel, M. Zheng, M.-H. the NAFLD Consensus Consortium

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics — from epidemiology, awareness, care and treatment to public health policies and leadership — that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD. © 2021, Springer Nature Limited.

Published
2022

40. Female Sex and Angiotensin-Converting Enzyme (ACE) Insertion/Deletion Polymorphism Amplify the Effects of Adiposity on Blood Pressure

Author

Chiriacò, Martina, primary, Tricò, Domenico, additional, Leonetti, Simone, additional, Petrie, John R., additional, Balkau, Beverley, additional, Højlund, Kurt, additional, Pataky, Zoltan, additional, Nilsson, Peter M, additional, Natali, Andrea, additional, Heine, R.J., additional, Dekker, J., additional, de Rooij, S., additional, Nijpels, G., additional, Boorsma, W., additional, Mitrakou, A., additional, Tournis, S., additional, Kyriakopoulou, K., additional, Thomakos, P., additional, Lalic, N., additional, Lalic, K., additional, Jotic, A., additional, Lukic, L., additional, Civcic, M., additional, Nolan, J., additional, Yeow, T.P., additional, Murphy, M., additional, DeLong, C., additional, Neary, G., additional, Colgan, M.P., additional, Hatunic, M., additional, Konrad, T., additional, Böhles, H., additional, Fuellert, S., additional, Baer, F., additional, Zuchhold, H., additional, Golay, A., additional, Harsch Bobbioni, E., additional, Barthassat, V., additional, Makoundou, V., additional, Lehmann, T.N.O., additional, Merminod, T., additional, Perry, C., additional, Neary, F., additional, MacDougall, C., additional, Shields, K., additional, Malcolm, L., additional, Laakso, M., additional, Salmenniemi, U., additional, Aura, A., additional, Raisanen, R., additional, Ruotsalainen, U., additional, Sistonen, T., additional, Laitinen, M., additional, Saloranta, H., additional, Coppack, S.W., additional, McIntosh, N., additional, Ross, J., additional, Pettersson, L., additional, Khadobaksh, P., additional, Laville, M., additional, Bonnet, F., additional, Brac de la Perriere, A., additional, Louche-Pelissier, C., additional, Maitrepierre, C., additional, Peyrat, J., additional, Beltran, S., additional, Serusclat, A., additional, Gabriel, R., additional, Sánchez, E.M., additional, Carraro, R., additional, Friera, A., additional, Novella, B., additional, Nilsson, P., additional, Persson, M., additional, Östling, G., additional, Melander, O., additional, Burri, P., additional, Piatti, P.M., additional, Monti, L.D., additional, Setola, E., additional, Galluccio, E., additional, Minicucci, F., additional, Colleluori, A., additional, Walker, M., additional, Ibrahim, I.M., additional, Jayapaul, M., additional, Carman, D., additional, Ryan, C., additional, Short, K., additional, McGrady, Y., additional, Richardson, D., additional, Beck-Nielsen, H., additional, Staehr, P., additional, Vestergaard, V., additional, Olsen, C., additional, Hansen, L., additional, Bolli, G.B., additional, Porcellati, F., additional, Fanelli, C., additional, Lucidi, P., additional, Calcinaro, F., additional, Saturni, A., additional, Ferrannini, E., additional, Muscelli, E., additional, Pinnola, S., additional, Kozakova, M., additional, Casolaro, A., additional, Astiarraga, B.D., additional, Mingrone, G., additional, Guidone, C., additional, Favuzzi, A., additional, Di Rocco, P., additional, Anderwald, C., additional, Bischof, M., additional, Promintzer, M., additional, Krebs, M., additional, Mandl, M., additional, Hofer, A., additional, Luger, A., additional, Waldhäusl, W., additional, Roden, M., additional, Dekker, J.M., additional, Mari, A., additional, Petrie, J., additional, Gaffney, P., additional, Boran, G., additional, Kok, A., additional, Patel, S., additional, Gastaldelli, A., additional, Ciociaro, D., additional, Guillanneuf, M.T., additional, Mhamdi, L., additional, Landucci, L., additional, Hills, S., additional, Mota, L., additional, Pacini, G., additional, Cavaggion, C., additional, Tura, A., additional, and Hills, S.A., additional

Published
2022
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42. Comparison of diabetes distress and depression screening results of emerging adults with type 1 diabetes onset at different ages: findings from the German early-onset T1D study and the German Diabetes Study (GDS).

Author

Stahl-Pehe, Anna, Bächle, Christina, Bódis, Kálmán, Zaharia, Oana-Patricia, Lange, Karin, Holl, Reinhard W., Roden, Michael, Rosenbauer, Joachim, for the GDS Group, Roden, M., Al-Hasani, H., Belgardt, B, Bönhof, GJ., Burkart, V, Buyken, A. E., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., and Kotzka, J.

Subjects
TYPE 1 diabetes, PSYCHOLOGICAL distress, AGE of onset, DIABETES, YOUNG adults, CAUSAL inference
Abstract

Background: Diabetes distress is increasingly considered one of the most important psychosocial issues in the care of people with type 1 diabetes (T1D). We analyse whether diabetes distress and depression screening results of emerging adults are associated with the age at T1D onset. Methods: Data were taken from two cohort studies conducted at the German Diabetes Center, Düsseldorf, Germany. The 18–30-year-old participants had an age at onset either before the age of 5 years (childhood-onset long-term T1D study group, N = 749) or during adulthood (adult-onset short-term T1D study group from the German Diabetes Study (GDS), N = 163). Diabetes distress and depression screening were analysed by means of the 20-item Problem Areas in Diabetes (PAID-20) scale and the nine-item depression module from the Patient Health Questionnaire (PHQ-9). The average causal effect of age at onset was estimated by a doubly robust causal inference method. Results: The PAID-20 total scores were increased in the adult-onset study group [potential outcome mean (POM) 32.1 (95% confidence interval 28.0; 36.1) points] compared to the childhood-onset study group [POM 21.0 (19.6; 22.4) points, difference 11.1 (6.9; 15.3) points, p<0.001] adjusted for age, sex and haemoglobin A1c (HbA1c) levels. Moreover, more participants in the adult-onset group [POM 34.5 (24.9; 44.2) %] than in the childhood-onset group [POM 16.3 (13.3; 19.2) %] screened positive for diabetes distress [adjusted difference 18.3 (8.3; 28.2) %, p<0.001]. The PHQ-9 total score [difference 0.3 (-1.1; 1.7) points, p=0.660] and the proportion of participants with a positive screening result for depression [difference 0.0 (-12.7; 12.8) %, p=0.994] did not differ between the groups in the adjusted analyses. Conclusions: Emerging adults with short-term type 1 diabetes screened positive for diabetes distress more often than adults with type 1 diabetes onset during early childhood when age, sex and HbA1c values were considered confounding factors. Accounting for age at onset or the duration of diabetes may help explain the heterogeneity in the data when psychological factors are examined. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection

Author

Scheiber, D., Zweck, E., Albermann, S., Jelenik, T., Spieker, M., Bönner, F., Horn, P., Schultheiss, H.P., Aleshcheva, G., Escher, F., Boeken, U., Akhyari, P., Roden, M., Kelm, M., Szendroedi, J., and Westenfeld, R.

Subjects
Heart Diseases, Heart failure, Original Articles, Mitochondria, Heart, Acute cellular heart transplant rejection, Oxidative Stress, Diabetes Mellitus, Type 2, Myocardial inflammation, RC666-701, Diseases of the circulatory (Cardiovascular) system, Heart Transplantation, Humans, Original Article, Acute Cellular Heart Transplant Rejection, Heart Failure, Mitochondrial Respiration, Myocardial Inflammation, Mitochondrial respiration
Abstract

AIMS: Acute cellular rejection (ACR) following heart transplantation (HTX) is associated with long-term graft loss and increased mortality. Disturbed mitochondrial bioenergetics have been identified as pathophysiological drivers in heart failure, but their role in ACR remains unclear. We aimed to prove functional disturbances of myocardial bioenergetics in human heart transplant recipients with mild ACR by assessing myocardial mitochondrial respiration using high-resolution respirometry, digital image analysis of myocardial inflammatory cell infiltration, and clinical assessment of HTX patients. We hypothesized that (i) mild ACR is associated with impaired myocardial mitochondrial respiration and (ii) myocardial inflammation, systemic oxidative stress, and myocardial oedema relate to impaired mitochondrial respiration and myocardial dysfunction. METHODS AND RESULTS: We classified 35 HTX recipients undergoing endomyocardial biopsy according International Society for Heart and Lung Transplantation criteria to have no (0R) or mild (1R) ACR. Additionally, we quantified immune cell infiltration by immunohistochemistry and digital image analysis. We analysed mitochondrial substrate utilization in myocardial fibres by high-resolution respirometry and performed cardiovascular magnetic resonance (CMR). ACR (1R) was diagnosed in 12 patients (34%), while the remaining 23 patients revealed no signs of ACR (0R). Underlying cardiomyopathies (dilated cardiomyopathy 50% vs. 65%; P=0.77), comorbidities (type 2 diabetes mellitus: 50% vs. 35%, P=0.57; chronic kidney disease stage 5: 8% vs. 9%, P>0.99; arterial hypertension: 59% vs. 30%, P=0.35), medications (tacrolimus: 100% vs. 91%, P=0.54; mycophenolate mofetil: 92% vs. 91%, P>0.99; prednisolone: 92% vs. 96%, P>0.99) and time post-transplantation (21.5±26.0months vs. 29.4±26.4months, P=0.40) were similar between groups. Mitochondrial respiration was reduced by 40% in ACR (1R) compared with ACR (0R) (77.8±23.0 vs. 128.0±33.0; P14 CD3+ -lymphocytes/mm2 (100% sensitivity, 82% specificity; P&nbsp

Published
2021
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