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We present the results of the optical follow-up, conducted by the TOROS collaboration, of gravitational wave events detected during the Advanced LIGO-Virgo second observing run (Nov 2016 -- Aug 2017). Given the limited field of view ($\sim100\arcmin$) of our observational instrumentation we targeted galaxies within the area of high localization probability that were observable from our sites. We analyzed the observations using difference imaging, followed by a Random Forest algorithm to discriminate between real and bogus transients. For all three events that we respond to, except GW170817, we did not find any bona fide optical transient that was plausibly linked with the observed gravitational wave event. Our observations were conducted using telescopes at Estaci\'{o}n Astrof\'{\i}sica de Bosque Alegre, Cerro Tololo Inter-American Observatory, and the Dr. Cristina V. Torres Memorial Astronomical Observatory. Our results are consistent with the LIGO-Virgo detections of a binary black hole merger (GW170104) for which no electromagnetic counterparts were expected, as well as a binary neutron star merger (GW170817) for which an optical transient was found as expected., Comment: 9 pages, 4 figures

We present a comparison of several Difference Image Analysis (DIA) techniques, in combination with Machine Learning (ML) algorithms, applied to the identification of optical transients associated with gravitational wave events. Each technique is assessed based on the scoring metrics of Precision, Recall, and their harmonic mean F1, measured on the DIA results as standalone techniques, and also in the results after the application of ML algorithms, on transient source injections over simulated and real data. This simulations cover a wide range of instrumental configurations, as well as a variety of scenarios of observation conditions, by exploring a multi dimensional set of relevant parameters, allowing us to extract general conclusions related to the identification of transient astrophysical events. The newest subtraction techniques, and particularly the methodology published in Zackay et al. (2016) are implemented in an Open Source Python package, named properimage, suitable for many other astronomical image analyses. This together with the ML libraries we describe, provides an effective transient detection software pipeline. Here we study the effects of the different ML techniques, and the relative feature importances for classification of transient candidates, and propose an optimal combined strategy. This constitutes the basic elements of pipelines that could be applied in searches of electromagnetic counterparts to GW sources., 18 pages, 8 figures, 2 tables, accepted for publication in Astronomy & Computing

We present the results of prompt optical follow-up of the electromagnetic counterpart of the gravitational-wave event GW170817 by the Transient Optical Robotic Observatory of the South Collaboration (TOROS). We detected highly significant dimming in the light curves of the counterpart (Delta g=0.17+-0.03 mag, Delta r=0.14+-0.02 mag, Delta i=0.10 +- 0.03 mag) over the course of only 80 minutes of observations obtained ~35 hr after the trigger with the T80-South telescope. A second epoch of observations, obtained ~59 hr after the event with the EABA 1.5m telescope, confirms the fast fading nature of the transient. The observed colors of the counterpart suggest that this event was a "blue kilonova" relatively free of lanthanides., Accepted for publication in The Astrophysical Journal Letters

We present the results of the optical follow-up conducted by the TOROS collaboration of the first gravitational-wave event GW150914. We conducted unfiltered CCD observations (0.35-1 micron) with the 1.5-m telescope at Bosque Alegre starting ~2.5 days after the alarm. Given our limited field of view (~100 square arcmin), we targeted 14 nearby galaxies that were observable from the site and were located within the area of higher localization probability. We analyzed the observations using two independent implementations of difference-imaging algorithms, followed by a Random-Forest-based algorithm to discriminate between real and bogus transients. We did not find any bona fide transient event in the surveyed area down to a 5-sigma limiting magnitude of r=21.7 mag (AB). Our result is consistent with the LIGO detection of a binary black hole merger, for which no electromagnetic counterparts are expected, and with the expected rates of other astrophysical transients., ApJ Letters, in press

In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines. Employing flow cytometry, it could be determined that mannan inhibits the proliferative response in normal and tumoral cells. Mannan affects the expression of CD3(+) SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response. Also in SpMC cultured with or without mitogen mannan produces an increase of an activation marker (CD25). On C1498 cell line, mannan reduces CD3 expression and abolishes the CD25 expression. In conclusion, mannan has a dual beneficial effect when applied to normal and tumoral cells at the same time by inhibiting the activation of cancer cells and improving that of normal ones.

Oxidized lipoproteins have been involved in the pathogenesis of atherosclerosis and atherosclerotic lesions contain oxidized low density lipoprotein. Conversely, the presence of oxidized high density lipoprotein (HDL) in vivo has not been clearly established. Oxidation of HDL in vitro models produces an increase in peroxidized lipids and the appearance of apolipoprotein A-I (apo A-I) oligomers. We investigated the oxidative status of HDL in an in vivo model: the hypercholesterolemic chicken. The HDLs from control and hyperlipemic animals were analyzed for the content of lipid peroxides employing spectroscopic and fluorescence techniques, for the level of apo A-I oligomerization, and for susceptibility to in vitro oxidation. HDL from hypercholesterolemic chickens was more peroxidized (as detected by fluorescence), had higher amount of oligomeric apo A-I, and was oxidized to a greater extent by uv irradiation than that of control animals. We speculate that apo A-I oligomerization could be a key step in the atheroma formation.