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18. Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic.

Author

Rodríguez-Fernández, Rosa, González-Martínez, Felipe, Perez-Moreno, Jimena, González-Sánchez, María Isabel, de la Mata Navazo, Sara, Toledo del Castillo, Blanca, Saavedra Lozano, Jesus, Voltas Espinosa, Lucia, Manso Perez, Sara, Miñarro Berlanga, María, Mejias, Asuncion, and Ramilo, Octavio

Subjects
*COVID-19, *SCIENTIFIC observation, *OXYGEN, *AGE distribution, *RETROSPECTIVE studies, *ACQUISITION of data, *SEASONS, *COMPARATIVE studies, *BRONCHIOLE diseases, *SYMPTOMS, *MEDICAL records, *DESCRIPTIVE statistics, *RESEARCH funding, *RESPIRATORY syncytial virus infections, *SOCIODEMOGRAPHIC factors, *COVID-19 pandemic, *PHENOTYPES, *HOSPITAL care of children, *CHILDREN
Abstract

Objective The main objective of this report was to comprehensively analyze the clinical characteristics of children hospitalized with respiratory syncytial virus (RSV) infections in 2021 during the coronavirus disease 2019 (COVID-19) pandemic and to compare them with those in the five previous RSV seasons. We hypothesized that the clinical and demographic features of children hospitalized with RSV infection in 2021 were different from those hospitalized in previous respiratory seasons. Study Design In this retrospective observational study, children younger than 2 years hospitalized with RSV bronchiolitis from January 1, 2015, to December 31, 2021, at the Department of Pediatrics of the Hospital Gregorio Marañón, Madrid, Spain, were included. We compared the clinical characteristics of children hospitalized with RSV bronchiolitis in the five seasons before the COVID-19 pandemic and during the subsequent off-seasonal surge of RSV infections. Results We found a significant reduction in hospitalizations for RSV bronchiolitis during the usual winter epidemic period due to the COVID-19 pandemic. Children hospitalized with RSV infection in 2021, during the COVID-19 pandemic, were older than children hospitalized in the prepandemic period (2015–2020; 4.0 [1.6–9.2] vs. 3 [1.5–6.5] months; p < 0.01). We also found shorter duration of oxygen days during the COVID-19 period compared with previous respiratory seasons (3 [2–5] vs. 4 [2–6] days; p = 0.02). Conclusion The COVID-19 pandemic modified the RSV seasonality with a significant reduction in RSV hospitalizations during the expected 2020–2021 season and a reappearance of RSV 7 months later than expected. We also found changes in the median age of children with RSV bronchiolitis during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic compared with the prepandemic RSV seasons and shorter duration of oxygen days suggesting a modest reduction in disease severity. We hypothesize that this observation reflects the lack of RSV circulation in the previous months (April 2020-March 2021), with a larger pool of vulnerable infants that had not been previously infected. Key Points The COVID-19 pandemic shifted RSV seasonality. RSV children hospitalized during the pandemic were older. Modest reduction in disease severity was observed during the pandemic. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic

Author

Rodríguez-Fernández, Rosa, additional, González-Martínez, Felipe, additional, Perez-Moreno, Jimena, additional, González-Sánchez, María Isabel, additional, de la Mata Navazo, Sara, additional, Toledo del Castillo, Blanca, additional, Saavedra Lozano, Jesus, additional, Voltas Espinosa, Lucia, additional, Manso Perez, Sara, additional, Miñarro Berlanga, María, additional, Mejias, Asuncion, additional, and Ramilo, Octavio, additional

Published
2022
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31. Prioritising respiratory syncytial virus prevention in low-income and middle-income countries

Author

Carbonell-Estrany, Xavier, Simões, Eric AF, Bont, Louis J, Paes, Bosco A, Ayuk, Adaeze, Gentile, Angela, Greenough, Anne, Moreno, Antonio, Sharma, Arun, Mejias, Asuncion, Rodgers-Gray, Barry, Resch, Bernhard, Fauroux, Brigette, Rodriguez-Martinez, Carlos E, El Saleeby, Chadi, Huskins, W Charles, Cohen, Cheryl, Greenberg, David, Baraldi, Eugenio, Anderson, Evan, Martinon Torres, Federico, Polack, Fernando F, Piedimonte, Giovanni, Nair, Harish, Gans, Hayley, Zar, Heather J, Moriuchi, Hiroyuki, Oshitani, Hitoshi, Mitchell, Ian, Nokes, D James, Sheikh, Jarju, Pernica, Jeffrey, Papenburg, Jesse, Robinson, Joan, De Jesus-Cornejo, Joanne, Langley, Joanne, Liese, Johannes, Figueras Aloy, Jose, Torres Torretti, Juan Pablo, Edwards, Kathryn, Krilov, Leonard, Divaratne, Maduja, Sanchez Luna, Manuel, Lanari, Marcello, Scotta, Marcelo, Garba, Maria, Mori, Masaaki, Cetinkaya, Merih, Goldstein, Mitchell, Khuri-Bulos, Najwa, Vain, Nestor E, Papadopoulus, Nikolaos, Homaira, Nusrat, Ramilo, Octavio, Manzoni, Paolo, Munywoki, Patrick, Piedra, Pedro A, Moschovis, Peter, Openshaw, Peter, Bassat, Quique, Stein, Renato, Thwaites, Richard, Muthugala, Rohitha, Ulloa-Gutierrez, Rolando, Dagan, Ron, Rodriguez Fernandez, Rosa, Kusuda, Satoshi, Madhi, Shabir, Broor, Shobha, Drysdale, Simon B, Basnet, Sudha, Heikkinen, Terho, Avadhanula, Vasanthi, Saez-Llorens, Xavier, Wang, Xin, Li, You, and Mathew, Joseph L

Published
2023
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36. Do we overestimate intravenous ?uid therapy needs? Adverse effects related to isotonic solutions during pediatric hospital admissions.

Author

Pérez-Moreno, Jimena, Gutiérrez-Vélez, Ana, Torres Soblechero, Laura, González Martínez, Felipe, Toledo del Castillo, Blanca, Vierge Hernán, Eva, and Rodríguez-Fernández, Rosa

Abstract

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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41. The Journey to an RSV Vaccine

Author

Mejias, Asuncion, Rodríguez-Fernández, Rosa, Oliva, Silvia, Peeples, Mark. E, and Ramilo, Octavio

Subjects
Male, viruses, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Vaccines, Humans, Female, Respiratory Syncytial Virus Infections, respiratory system, Article
Abstract

OBJECTIVE: The high burden associated with respiratory syncytial virus (RSV), has made the development of RSV vaccine(s) a global health high priority. This review summarizes the ourney to an RSV vaccine, the different strategies and challenges associated with the development of preventive strategies for RSV, and the diverse products that are undergoing clinical testing. DATA SOURCES: Studies on RSV biology, immunology, epidemiology and monoclonal antibodies and vaccines were searched using MEDLINE. We also searched https://path.org and ClinicalTrials.gov for updated information regarding the status of RSV vaccines and monoclonal antibodies undergoing clinical trials. STUDY SELECTIONS: We selected relevant studies conducted in infants and young children, pregnant women and the elderly for the prevention of RSV infection. RESULTS: Identification of a safe and immunogenic vaccine has been an important but elusive initiative for over 60 years for different reasons including the legacy of formalininactivated vaccine, our limited understanding of the immune response to RSV and how it relates to clinical disease severity or the need for different endpoints according to the different vaccine platforms. Nevertheless, there are currently 39 vaccines and monoclonal antibodies under development and 19 undergoing clinical trials. CONCLUSION: Over the past decade there have been significant advances in our knowledge of RSV molecular and structural biology, and in understanding the human immune response to RSV. Despite the barriers, there are several promising monoclonal antibodies and RSV vaccines undergoing clinical trials that hope to offer protection to the most vulnerable populations

Published
2020

42. The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review

Author

Sainz, Talía, primary, Delgado, Jaime, additional, Mendez‐Echevarría, Ana, additional, Santiago, Begoña, additional, Lopez‐Varela, Elisa, additional, Aguilera‐Alonso, David, additional, Saavedra‐Lozano, Jesús, additional, Rodríguez‐Fernández, Rosa, additional, Holguín, África, additional, Navarro, Marisa L., additional, Muñoz‐Fernández, María Ángeles, additional, Rivero‐Calle, Irene, additional, Solana, María José, additional, López‐Herce, Jesús, additional, and Calvo, Cristina, additional

Published
2020
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44. Base De Datos 'Producción Científica Cubana Sobre Biofertilizantes: Un Análisis Bilbiométrico En Revistas Extranjeras'

Author

Peña-Borrego, Maida Daylin, de Zayas-Pérez, María Rosa, and Rodríguez-Fernández, Rosa Margarita

Subjects
productividad, revistas, bibliometría, biofertilizantes, investigadores cubanos
Abstract

Se presentan los registros de las publicaciones científicas de autores o co-autores cubanos en revistas extranjeras, desplegados en hojas de calculo en excel donde se contemplan en varias columnas los registro: Tìtulo, Autores, Palabras Claves, Microorganismo, Cultivos agrícola, Año de publicación ,Revista, Instituto Nacionales, Instituto Internacionales, Base de datos de la publicación

Published
2018
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48. The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review.

Author

Sainz, Talía, Delgado, Jaime, Mendez‐Echevarría, Ana, Santiago, Begoña, Lopez‐Varela, Elisa, Aguilera‐Alonso, David, Saavedra‐Lozano, Jesús, Rodríguez‐Fernández, Rosa, Holguín, África, Navarro, Marisa L., Muñoz‐Fernández, María Ángeles, Rivero‐Calle, Irene, Solana, María José, López‐Herce, Jesús, and Calvo, Cristina

Subjects
COMMUNICABLE diseases, HUMAN microbiota, JUVENILE diseases, DIAGNOSIS, THERAPEUTICS, EMERGING infectious diseases
Abstract

In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge. Aims: This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children. Methods: We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice. Results and Conclusion: The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Estudio métrico de la temática agraria en el periódico cubano Granma en el año 2019.

Author

Daylin Peña-Borrego, Maida, Virginia González-Guitián, María, Margarita Rodríguez-Fernández, Rosa, and Rosa de Zayas-Pérez, María

Subjects
NEWSPAPER sections, columns, etc., AGRICULTURAL productivity, NEWSPAPER publishing, COOPERATIVE agriculture, FISH farming, ELECTRONIC newspapers, COPYING
Abstract

Copyright of Revista General de Información y Documentación is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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50. Percepción de los adolescentes sobre el ingreso hospitalario: Importancia de la humanización de los hospitales infantiles

Author

Butragueño Laiseca, Laura, González Martínez, Felipe, Oikonomopoulou, Niki, Pérez Moreno, Jimena, Toledo del Castillo, Blanca, González Sánchez, María Isabel, and Rodríguez Fernández, Rosa

Subjects
Medidas de humanización, Humanisation of assistance, Hospital care, Humanisation policy, Asistencia hospitalaria, Adolescente hospitalizado, Humanización hospitalaria, Hospitalised adolescent
Abstract

Introducción: La humanización de la asistencia sanitaria conlleva considerar al paciente como un ser integral, y proporcionar asistencia más allá de los cuidados médicos, abarcando áreas como la social, emocional, espiritual y relacional. Objetivo: Conocer las necesidades de los adolescentes hospitalizados y los déficits percibidos por estos en la asistencia sanitaria. Sujetos y método: Estudio transversal descriptivo realizado a través de una encuesta anónima, dirigido a pacientes ingresados de entre 12-16 años. La encuesta estaba formada por 2 partes: preguntas abiertas para exponer sus necesidades, indicar aspectos positivos o negativos de la hospitalización, y sugerencias de mejora, y preguntas cerradas con posibles respuestas afirmativas o negativas, y escalas numéricas del 1 al 10 para cuantificar los resultados. Se llevó a cabo un pilotaje previo en 6 pacientes adolescentes como prueba de factibilidad y de comprensión de todos los apartados. Resultados: Se obtuvieron un total de 39 encuestas de pacientes, con una mediana de edad de 14 años. La experiencia más desagradable percibida durante el ingreso fue la realización de pruebas invasivas. El 95% de ellos padeció dolor y el 17% sintió en algún momento que se iba a realizar algún procedimiento sin su pleno conocimiento. Más del 75% demandaba más entretenimiento, siendo la no disponibilidad de Wi-Fi el elemento más reclamado. Conclusiones: La población estudiada mostró necesidades que deben ser consideradas en el momento de la hospitalización, destacando: cognitivas (necesidad de obtener información clara y extensa), sociales (mantener el contacto y las relaciones con el exterior, familiares y amigos), emocionales (la enfermedad y sus procesos diagnóstico-terapéuticos crearán alteraciones en el estado anímico) y prácticas (los aspectos ambientales y arquitectónicos pueden mejorar o empeorar la percepción del ingreso hospitalario). Todos estos factores han demostrado que pueden contribuir al restablecimiento de la salud de una forma más temprana. Introduction: The humanisation of health care involves considering the patient as an integral human being, providing assistance beyond medical care, and covering other fields such as social, emotional, spiritual, or relational areas. Objective: To evaluate the requirements and concerns of the hospitalised children. Subjects and method: A cross-sectional, descriptive study was conducted using an anonymous questionnaire on children aged 12-16. Results: The study included 39 patients, with a median age of 14 years. The most unpleasant experience during the hospitalisation was the invasive procedures. Almost all (95%) of patients suffered from pain, and 17% of them felt at some point that a procedure was performed without them being fully aware. More than 75% of children asked for more entertainment, with the lack of Wi-Fi being the more demanded item. Conclusions: The needs of the population included in this survey, showed the importance to consider cognitive (necessity of obtaining clear and extensive information), social (maintaining everyday relationships), emotional (illness and its diagnostic and therapeutic procedures often generate mood disorders), and practical (environmental and architectural aspects can lead to either an improvement or a worsening of the hospitalisation perception) factors. All of these factors have shown a beneficial contribution, leading to an earlier recovery of health.

Published
2016

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