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34 results on '"Rodríguez-González, Guadalupe L."'

5. Programming Mechanism of Adipose Tissue Expansion in the Rat Offspring of Obese Mothers Occurs in a Sex-Specific Manner

Author

Ibáñez, Carlos A., primary, Lira-León, Gabriela, additional, Reyes-Castro, Luis A., additional, Rodríguez-González, Guadalupe L., additional, Lomas-Soria, Consuelo, additional, Hernández-Rojas, Alejandra, additional, Bravo-Flores, Eyerahí, additional, Solis-Paredes, Juan Mario, additional, Estrada-Gutierrez, Guadalupe, additional, and Zambrano, Elena, additional

Published
2023
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6. Developmental Programming-Aging Interactions Have Sex-Specific and Developmental Stage of Exposure Outcomes on Life Course Circulating Corticosterone and Dehydroepiandrosterone (DHEA) Concentrations in Rats Exposed to Maternal Protein-Restricted Diets

Author

Zambrano, Elena, primary, Reyes-Castro, Luis A., additional, Rodríguez-González, Guadalupe L., additional, Chavira, Roberto, additional, Lomas-Soria, Consuelo, additional, Gerow, Kenneth G., additional, and Nathanielsz, Peter W., additional

Published
2023
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9. High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life.

Author

Rodríguez-González, Guadalupe L., De Los Santos, Sergio, Méndez-Sánchez, Dayana, Reyes-Castro, Luis A., Ibáñez, Carlos A., Canto, Patricia, and Zambrano, Elena

Subjects
OBESITY complications, BLOOD sugar analysis, MOTHERS, LACTATION, THERAPEUTICS, TRIGLYCERIDES, ADRENOCORTICAL hormones, BODY weight, ANIMAL experimentation, LEPTIN, METABOLIC disorders, INSULIN, PUERPERIUM, FAT cells, RESEARCH funding, DIETARY fats, ADIPOSE tissues, INSULIN resistance, DISEASE risk factors
Abstract

Obese mothers' offspring develop obesity and metabolic alterations in adulthood. Poor postnatal dietary patterns also contribute to obesity and its comorbidities. We aimed to determine whether in obese mothers' offspring an adverse postnatal environment, such as high-fat diet (HFD) consumption (second hit) exacerbates body fat accumulation, metabolic alterations and adipocyte size distribution. Female Wistar rats ate chow (C-5 %-fat) or HFD (maternal obesity (MO)-25 %-fat) from weaning until the end of lactation. Male offspring were weaned on either control (C/C and MO/C, maternal diet/offspring diet) or HFD (C/HF and MO/HF) diet. At 110 postnatal days, offspring were killed. Fat depots were excised to estimate adiposity index (AI). Serum glucose, triglyceride, leptin, insulin, insulin resistance index (HOMA-IR), corticosterone and dehydroepiandrosterone (DHEA) were determined. Adipocyte size distribution was evaluated in retroperitoneal fat. Body weight was similar in C/C and MO/C but higher in C/HF and MO/HF. AI, leptin, insulin and HOMA-IR were higher in MO/C and C/HF v. C/C but lower than MO/HF. Glucose increased in MO/HF v. MO/C. C/HF and MO/C had higher triglyceride and corticosterone than C/C, but lower corticosterone than MO/HF. DHEA and the DHEA/corticosterone ratio were lower in C/HF and MO/C v. C/C, but higher than MO/HF. Small adipocyte proportion decreased while large adipocyte proportions increased in MO/C and C/HF v. C/C and exacerbated in MO/HF v. C/HF. Postnatal consumption of a HFD by the offspring of obese mothers exacerbates body fat accumulation as well as the decrease of small and the increase of large adipocytes, which leads to larger metabolic abnormalities. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

Author

Rodríguez-González, Guadalupe L., primary, Vargas-Hernández, Lilia, additional, Reyes-Castro, Luis A., additional, Ibáñez, Carlos A., additional, Bautista, Claudia J., additional, Lomas-Soria, Consuelo, additional, Itani, Nozomi, additional, Estrada-Gutierrez, Guadalupe, additional, Espejel-Nuñez, Aurora, additional, Flores-Pliego, Arturo, additional, Montoya-Estrada, Araceli, additional, Reyes-Muñoz, Enrique, additional, Taylor, Paul D., additional, Nathanielsz, Peter W., additional, and Zambrano, Elena, additional

Published
2022
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12. Sex-differential RXRα gene methylation effects on mRNA and protein expression in umbilical cord of the offspring rat exposed to maternal obesity

Author

Chavira-Suárez, Erika, primary, Reyes-Castro, Luis Antonio, additional, López-Tenorio, Itzel Ivonn, additional, Vargas-Hernández, Lilia, additional, Rodríguez-González, Guadalupe L., additional, Chavira, Roberto, additional, Zárate-Segura, Paola, additional, Domínguez-López, Aaron, additional, Vadillo-Ortega, Felipe, additional, and Zambrano, Elena, additional

Published
2022
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14. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring

Author

Zambrano, Elena, primary, Rodríguez-González, Guadalupe L., additional, Reyes-Castro, Luis A., additional, Bautista, Claudia J., additional, Castro-Rodríguez, Diana C., additional, Juárez-Pilares, Gimena, additional, Ibáñez, Carlos A., additional, Hernández-Rojas, Alejandra, additional, Nathanielsz, Peter W., additional, Montaño, Sara, additional, Arredondo, Armando, additional, Huang, Fengyang, additional, and Bolaños-Jiménez, Francisco, additional

Published
2021
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21. Maternal obesity accelerates rat offspring metabolic ageing in a sex‐dependent manner

Author

Rodríguez‐González, Guadalupe L., primary, Reyes‐Castro, Luis A., additional, Bautista, Claudia J., additional, Beltrán, Azucena A., additional, Ibáñez, Carlos A., additional, Vega, Claudia C., additional, Lomas‐Soria, Consuelo, additional, Castro‐Rodríguez, Diana C., additional, Elías‐López, Ana L., additional, Nathanielsz, Peter W., additional, and Zambrano, Elena, additional

Published
2019
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23. Different Statistical Approaches to Characterization of Adipocyte Size in Offspring of Obese Rats: Effects of Maternal or Offspring Exercise Intervention

Author

Ibáñez, Carlos A., primary, Vázquez-Martínez, Magaly, additional, León-Contreras, J. Carlos, additional, Reyes-Castro, Luis A., additional, Rodríguez-González, Guadalupe L., additional, Bautista, Claudia J., additional, Nathanielsz, Peter W., additional, and Zambrano, Elena, additional

Published
2018
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26. Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition

Author

Lima-Posada, Ixchel, primary, Portas-Cortés, Cinthya, additional, Pérez-Villalva, Rosalba, additional, Fontana, Francesco, additional, Rodríguez-Romo, Roxana, additional, Prieto, Rodrigo, additional, Sánchez-Navarro, Andrea, additional, Rodríguez-González, Guadalupe L., additional, Gamba, Gerardo, additional, Zambrano, Elena, additional, and Bobadilla, Norma A., additional

Published
2017
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29. Effects of Late Gestational Fetal Exposure to Dexamethasone Administration on the Postnatal Hypothalamus-Pituitary-Adrenal Axis Response to Hypoglycemia in Pigs.

Author

Schiffner, René, Rodríguez-González, Guadalupe L., Rakers, Florian, Nistor, Marius, Nathanielsz, Peter W., Daneva, Teodora, Schwab, Matthias, Lehmann, Thomas, and Schmidt, Martin

Subjects
*HYPOGLYCEMIA, *SWINE diseases, *ADRENOCORTICOTROPIC hormone, *HYDROCORTISONE, *DEXAMETHASONE, *METABOLIC syndrome
Abstract

Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pituitary-adrenocortical axis (HPAA), and correspondingly the adenocorticotropic hormone (ACTH) and cortisol levels after birth. The dosages required for these effects are critically discussed. Activation of the HPAA is related to metabolic syndrome and diabetes mellitus. Hypoglycemia is the classic side effect of antidiabetic treatment. We hypothesized that a low dosage of dexamethasone in late pregnancy alters the HPAA response to hypoglycemia in pigs. Methods: 12 pregnant sows were randomly assigned to two groups which received either a low-dose intramuscular injection (99th and 100th day of gestation) of dexamethasone (0.06 μg/kg body weight) or vehicle. Three months after birth, 18 dexamethasone-treated anaesthetized offspring and 12 control offspring underwent a 75 min hypoglycemic clamp (blood glucose below 4 mmol/L) procedure. Heart rate (HR), blood pressure, ACTH and cortisol levels and body weight (at birth and after three months) were recorded. Results: Dexamethasone-treated animals exhibited significantly elevated ACTH (139.9 ± 12.7 pg/mL) and cortisol (483.1 ± 30.3 nmol/L) levels during hypoglycemia as compared to the control group (41.7 ± 6.5 pg/mL and 257.9 ± 26.7 nmol/L, respectively), as well as an elevated HR (205.5 ± 5.7 bpm) and blood pressure (systolic: 128.6 ± 1.5, diastolic: 85.7 ± 0.7 mmHg) response as compared to the control group (153.2 ± 4.5 bpm; systolic: 118.6 ± 1.6, diastolic: 79.5 ± 1.4 mmHg, respectively; p < 0.001). Conclusions: Low-dose prenatal administration of dexamethasone not only exerts effects on the HPAA (ACTH and cortisol concentration) and vital parameters (HR and diastolic blood pressure) under baseline conditions, but also on ACTH, HR and systolic blood pressure during hypoglycemia. [ABSTRACT FROM AUTHOR]

Published
2017
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33. Pregnancy and Lactation: A Window of Opportunity to Improve Individual Health.

Author

Rodríguez-González GL, Castro-Rodríguez DC, and Zambrano E

Subjects
Animals, Diet, Disease Susceptibility, Early Intervention, Educational, Environment, Female, Humans, Infant, Infant, Newborn, Perinatal Care, Pregnancy, Public Health Surveillance, Lactation, Maternal Health
Abstract

Human and animal studies indicate that obesity during pregnancy adversely impacts both maternal health and offspring phenotype predisposing them to chronic diseases later in life including obesity, dyslipidemia, type 2 diabetes mellitus, and hypertension. Effective interventions during human pregnancy and/or lactation are needed to improve both maternal and offspring health. This review addresses the relationship between adverse perinatal insults and its negative impact on offspring development and presents some maternal intervention studies such as diet modification, probiotic consumption, or maternal exercise, to prevent or alleviate the negative outcomes in both the mother and her child.

Published
2018
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34. Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats.

Author

Santos M, Rodríguez-González GL, Ibáñez C, Vega CC, Nathanielsz PW, and Zambrano E

Subjects
Adiposity physiology, Aging, Animals, Diet, High-Fat, Eating physiology, Female, Leptin metabolism, Male, Overweight metabolism, Physical Conditioning, Animal, Pregnancy, Rats, Wistar, Sex Factors, Motor Activity physiology, Obesity physiopathology, Oxidative Stress physiology, Prenatal Exposure Delayed Effects, Reproduction physiology
Abstract

Exercise improves health but few data are available regarding benefits of exercise in offspring exposed to developmental programming. There is currently a worldwide epidemic of obesity. Obesity in pregnant women predisposes offspring to obesity. Maternal obesity has well documented effects on offspring reproduction. Few studies address ability of offspring exercise to reduce adverse outcomes. We observed increased oxidative stress and impaired sperm function in rat offspring of obese mothers. We hypothesized that regular offspring exercise reverses adverse effects of maternal obesity on offspring sperm quality and fertility. Female Wistar rats ate chow (C) or high-energy, obesogenic diet (MO) from weaning through lactation, bred at postnatal day (PND) 120, and ate their pregnancy diet until weaning. All offspring ate C diet from weaning. Five male offspring (different litters) ran on a wheel for 15 min, 5 times/week from PND 330 to 450 and were euthanized at PND 450. Average distance run per session was lower in MO offspring who had higher body weight, adiposity index, and gonadal fat and showed increases in testicular oxidative stress biomarkers. Sperm from MO offspring had reduced antioxidant enzyme activity, lower sperm quality, and fertility. Exercise in MO offspring decreased testicular oxidative stress, increased sperm antioxidant activity and sperm quality, and improved fertility. Exercise intervention has beneficial effects on adiposity index, gonadal fat, oxidative stress markers, sperm quality, and fertility. Thus regular physical exercise in male MO offspring recuperates key male reproductive functions even at advanced age: it's never too late., (Copyright © 2015 the American Physiological Society.)

Published
2015
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