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36 results on '"Rodríguez-Martín, Inmaculada"'

5. A Heuristic Approach to the Driver and Vehicle Routing Problem

Author

Domínguez-Martín, Bencomo, Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Cerulli, Raffaele, editor, Raiconi, Andrea, editor, and Voß, Stefan, editor

Published
2018
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9. Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

Author

Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Ministerio de Universidades (España), Rodríguez-Martín, Inmaculada, Villanueva-Martín, Gonzalo, Guillén del Castillo, Alfredo, Ortego-Centeno, N., Callejas-Rubio, J. L., Simeón, Carmen P., Martín, Javier, Acosta-Herrera, Marialbert, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Ministerio de Universidades (España), Rodríguez-Martín, Inmaculada, Villanueva-Martín, Gonzalo, Guillén del Castillo, Alfredo, Ortego-Centeno, N., Callejas-Rubio, J. L., Simeón, Carmen P., Martín, Javier, and Acosta-Herrera, Marialbert

Abstract

Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528–0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563–0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc.

Published
2023

10. III ENCUENTRO DE COMITÉS DE IGUALDAD CSIC.

Author

Gómez-Díaz, Elena, Pérez-Sánchez-Cañete, María M., Canet, Luz, Matesanz, Fuencisla, Acosta-Herrera, Marialbert, Martínez-Arribas, Blanca, Duarte Ruiz, María, Ortiz-Fernández, Lourdes, Sánchez Medina, Manuel, Rodríguez-Martín, Inmaculada, Borrego Yaniz, Gonzalo, Gómez-Díaz, Elena, Pérez-Sánchez-Cañete, María M., Canet, Luz, Matesanz, Fuencisla, Acosta-Herrera, Marialbert, Martínez-Arribas, Blanca, Duarte Ruiz, María, Ortiz-Fernández, Lourdes, Sánchez Medina, Manuel, Rodríguez-Martín, Inmaculada, and Borrego Yaniz, Gonzalo

Abstract

Congresos y comunicaciones: Conferencias.

Published
2023

11. Estudio de la influencia de la longitud de los telómeros como factor de riesgo en la esclerosis sistémica.

Author

Rodríguez-Martín, Inmaculada, Villanueva-Martín, Gonzalo, SIMON MATEO, CARMEN, Guillén, A., Ortego-Centeno, Norberto, Callejas, Jose Luis, Acosta-Herrera, Marialbert, Martin, Javier, Rodríguez-Martín, Inmaculada, Villanueva-Martín, Gonzalo, SIMON MATEO, CARMEN, Guillén, A., Ortego-Centeno, Norberto, Callejas, Jose Luis, Acosta-Herrera, Marialbert, and Martin, Javier

Published
2023

14. An Iterated Local Search Heuristic for a Capacitated Hub Location Problem

Author

Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Almeida, Francisco, editor, Blesa Aguilera, María J., editor, Blum, Christian, editor, Moreno Vega, José Marcos, editor, Pérez Pérez, Melquíades, editor, Roli, Andrea, editor, and Sampels, Michael, editor

Published
2006
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15. Decomposition Approaches for a Capacitated Hub Problem

Author

Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Lemaître, Christian, editor, Reyes, Carlos A., editor, and González, Jesús A., editor

Published
2004
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22. Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome.

Author

Cerván-Martín, Miriam, Bossini-Castillo, Lara, Guzmán-Jimenez, Andrea, Rivera-Egea, Rocío, Garrido, Nicolás, Luján, Saturnino, Romeu, Gema, Santos-Ribeiro, Samuel, Castilla, José A., Gonzalvo, M. Carmen, Clavero, Ana, Vicente, F. Javier, Maldonado, Vicente, González-Muñoz, Sara, Rodríguez-Martín, Inmaculada, Burgos, Miguel, Jiménez, Rafael, Pinto, Maria Graça, Pereira, Isabel, and Nunes, Joaquim

Subjects
PEPTIDYLPROLYL isomerase, SINGLE nucleotide polymorphisms, MALE infertility, GENETIC variation, OLIGOSPERMIA, LOCUS (Genetics)
Abstract

We aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood–testis barrier, in the genetic risk of developing male infertility due to a severe spermatogenic failure (SPGF). Genotyping was performed using TaqMan genotyping assays for three PIN1 taggers (rs2287839, rs2233678 and rs62105751). The study cohort included 715 males diagnosed with SPGF and classified as suffering from non-obstructive azoospermia (NOA, n = 505) or severe oligospermia (SO, n = 210), and 1058 controls from the Iberian Peninsula. The allelic frequency differences between cases and controls were analyzed by the means of logistic regression models. A subtype specific genetic association with the subset of NOA patients classified as suffering from the Sertoli cell-only (SCO) syndrome was observed with the minor alleles showing strong risk effects for this subset (ORaddrs2287839 = 1.85 (1.17–2.93), ORaddrs2233678 = 1.62 (1.11–2.36), ORaddrs62105751 = 1.43 (1.06–1.93)). The causal variants were predicted to affect the binding of key transcription factors and to produce an altered PIN1 gene expression and isoform balance. In conclusion, common non-coding single-nucleotide polymorphisms located in PIN1 increase the genetic risk to develop SCO. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Cycle location problems

Author

Rodríguez Martín, Inmaculada and Moreno Pérez, José Andrés

Subjects
Grafos, Teoría de
Abstract

Estudio de los Problemas del Ciclo Mediana (MCP), consistentes en ubicar en un grafo completo mixto un ciclo que visita un determinado vértice, teniendo en cuenta el costo total de establecimiento del ciclo y el costo total de accesibilidad al mismo, definiéndose este último como la suma de las distancias de los vértices no visitados al ciclo. Se presenta y describe una nueva técnica metaheurística denominada Búsqueda Tabú de Entorno Variable (VNTS) para la resolución de los MCP.

Published
2000

31. The ring/ κ-rings network design problem: Model and branch-and-cut algorithm.

Author

Rodríguez‐Martín, Inmaculada, Salazar‐González, Juan‐José, and Yaman, Hande

Subjects
ALGORITHMS, ALGEBRA
Abstract

This article considers the problem of designing a two-level network where the upper level consists of a backbone ring network connecting the so-called hub nodes, and the lower level is formed by access ring networks that connect the non-hub nodes to the hub nodes. There is a fixed cost for each type of link, and a facility opening cost associated to each hub. The number of nodes in each access ring is bounded, and the number of access rings connected to a hub is limited to [ABSTRACT FROM AUTHOR]

Published
2016
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33. An Iterated Local Search Heuristic for a Capacitated Hub Location Problem.

Author

Almeida, Francisco, Aguilera, María J. Blesa, Blum, Christian, Vega, José Marcos Moreno, Pérez, Melquíades Pérez, Roli, Andrea, Sampels, Michael, Rodríguez-Martín, Inmaculada, and Salazar-González, Juan-José

Abstract

This paper addresses a capacitated hub problem consisting of choosing the routes and the hubs to use in order to send a set of commodities from sources to destinations in a given capacitated network with minimum cost. The capacities and costs of the arcs and hubs are given, and the graph connecting the hubs is not assumed to be complete. For solving this problem we propose a heuristic approach that makes use of a linear programming relaxation in an Iterated Local Search scheme. The heuristic turns out to be very effective and the results of the computational experiments show that near-optimal solutions can be derived rapidly for instances of large size. [ABSTRACT FROM AUTHOR]

Published
2006
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36. DisPar: a parallel code to simulate observational effects, and MkBundle+: a graphical interface to create the input file of a code to calculate star formation histories

Author

Luis Aznar, Manuel, Russo Cabrera, Anthony Vittorio, Rodríguez Martín, Inmaculada, and Salazar González, Juan José

Abstract

Este proyecto fue desarrollado junto con la colaboración de investigadores pertenecientes al Grupo de Poblaciones Estelares en Galaxias (GPEG) del Instituto de Astrofísica de Canarias (IAC) y tiene dos objetivos principales: Minimizar el tiempo de ejecución de un algoritmo que mitiga los errores fotométricos introducidos por las fluctuaciones de luminosidad en los datos captados en observación (efecto crowding). Para ello, se desarrolló un programa por línea de comandos escrito en C++, que es capaz de manejar grandes volúmenes de datos y que se vale, tanto de estructuras de datos eficientes, como del paralelismo sobre CPU y GPU para lograr este cometido. Facilitar la representación gráfica y la manipulación de datos de forma amigable. Para cumplir este cometido, se analizó y aprovechó una parte de los scripts en Python -realizado por los investigadores- para crear una aplicación gráfica en PyQt global que los integre. Se puede destacar la capacidad para manipular diferentes sesiones de usuario y representar, mediante Matplotlib, los datos leídos en formato FITS, entre otras funcionalidades.

Published
2016

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