16 results on '"Rodríguez-Tenreiro Sánchez, Carmen"'
Search Results
2. COVID‐19 vaccine effectiveness in children by age groups. A population‐based study in Galicia, Spain
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Mallah, Narmeen, primary, Pardo‐Seco, Jacobo, additional, Ares‐Gómez, Sonia, additional, López‐Pérez, Luis‐Ricardo, additional, González‐Pérez, Juan‐Manuel, additional, Rosón, Benigno, additional, Otero‐Barrós, María‐Teresa, additional, Durán‐Parrondo, Carmen, additional, Nartallo‐Penas, Victoria, additional, Mirás‐Carballal, Susana, additional, Rodríguez‐Tenreiro‐Sánchez, Carmen, additional, Rivero‐Calle, Irene, additional, Gómez‐Carballa, Alberto, additional, Salas, Antonio, additional, and Martinón‐Torres, Federico, additional
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- 2023
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3. Whole exome sequencing identifies new susceptibility candidates underlying community-acquired pneumonia
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Pardo-Seco, Jacobo, Viz-Lasheras, Sandra, Bello, Xabier, Gómez-Carballa, Alberto, Camino-Mera, Alba, Pischedda, Sara, Currás-Tuala, María José, Rivero-Calle, Irene, Dacosta-Urbieta, Ana, Caamaño-Viña, Fernando, Rodríguez-Tenreiro Sánchez, Carmen, Cifuentes, Isabel, Méndez, Cristina, Khor, Chiea Chuen, Martinón-Torres, Federico, and Salas, Antonio
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- 2024
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4. A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity
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Alberto Gómez-Carballa, Irene Rivero-Calle, Jacobo Pardo-Seco, José Gómez-Rial, Carmen Rivero-Velasco, Nuria Rodríguez-Núñez, Gema Barbeito-Castiñeiras, Hugo Pérez-Freixo, Miriam Cebey-López, Ruth Barral-Arca, Carmen Rodriguez-Tenreiro, Ana Dacosta-Urbieta, Xabier Bello, Sara Pischedda, María José Currás-Tuala, Sandra Viz-Lasheras, Federico Martinón-Torres, Antonio Salas, Aguilera Guirao Antonio, Álvarez Escudero Julián, Antela López Antonio, Barbeito Castiñeiras Gema, Bello Paderne Xabier, Ben García Miriam, Carral García María Victoria, Cebey López Miriam, Coira Nieto Amparo, Conde Pájaro Mónica, Costa Alcalde José Javier, Currás Tuala María José, Dacosta Urbieta Ana Isabel, Díaz Esteban Blanca, Domínguez Santalla María Jesús, Fernández Pérez Cristina, Fernández Villaverde Juan, Galbán Rodríguez Cristóbal, García Allut José Luis, García Vicente Luisa, Giráldez Vázquez Elena, Gómez Carballa Alberto, Gómez Rial José, González Barcala Francisco Javier, Guerra Liñares Beatriz, Leboráns Iglesias Pilar, Lence Massa Beatriz, López Franco Montserrat, López Lago Ana, Martinón-Torres Federico, Navarro De la Cruz Daniel, Núñez Masid Eloína, Ortolá Devesa Juan Bautista, Pardo Seco Jacobo, Pazo Núñez María, Pérez del Molino Bernal Marisa, Pérez Freixo Hugo, Piñeiro Rodríguez Lidia, Pischedda Sara, Portela Romero Manuel, Pose Reino Antonio, Prada Hervella Gloria María, Queiro Verdes Teresa, Redondo Collazo Lorenzo, Regueiro Casuso Patricia, Rey García Susana, Rey Vázquez Sara, Riveiro Blanco Vanessa, Rivero Calle Irene, Rivero Velasco Carmen, Rodríguez Núñez Nuria, Rodríguez-Tenreiro Sánchez Carmen, Saborido Paz Eva, Sadiki Orayyou José Miguel, Saito Villanueva Carla, Serén Fernández Sonia, Souto Sanmartín Pablo, Taboada Muñiz Manuel, Trastoy Pena Rocío, Treviño Castellano Mercedes, Valdés Cuadrado Luis, Varela García Pablo, Vilas Iglesias María Soledad, Viz Lasheras Sandra, Ferreiro-Iglesias Rocio, null Bastón-Rey iria, Calviño-Suárez Cristina, and Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
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SARS-CoV-2 ,Gene Expression Profiling ,COVID-19 ,Multi-tissue ,COVID-19 severity ,Biochemistry ,Antiviral Agents ,Immunity, Innate ,Co-expression analysis ,Nasal Mucosa ,Pathways analysis ,Humans ,Gene expression ,Immune response ,Differential expression analysis ,Biomarkers ,General Environmental Science - Abstract
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness; the cause for this differential response to infection remains unknown. Unravelling the immune mechanisms acting at different levels of the colonization process might be key to understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis of immune-related genes from patients affected by different COVID-19 severities, and healthy controls through the nCounter technology. Mild and asymptomatic cases showed a powerful innate antiviral response in nasal epithelium, characterized by activation of interferon (IFN) pathway and downstream cascades, successfully controlling the infection at local level. In contrast, weak macrophage/monocyte driven innate antiviral response and lack of IFN signalling activity were present in severe cases. Consequently, oral mucosa from severe patients showed signals of viral activity, cell arresting and viral dissemination to the lower respiratory tract, which ultimately could explain the exacerbated innate immune response and impaired adaptative immune responses observed at systemic level. Results from saliva transcriptome suggest that the buccal cavity might play a key role in SARS-CoV-2 infection and dissemination in patients with worse prognosis. Co-expression network analysis adds further support to these findings, by detecting modules specifically correlated with severity involved in the abovementioned biological routes; this analysis also provides new candidate genes that might be tested as biomarkers in future studies. We also found tissue specific severity-related signatures mainly represented by genes involved in the innate immune system and cytokine/chemokine signalling. Local immune response could be key to determine the course of the systemic response and thus COVID-19 severity. Our findings provide a framework to investigate severity host gene biomarkers and pathways that might be relevant to diagnosis, prognosis, and therapy This study received support from Instituto de Salud Carlos III (ISCIII): GePEM (PI16/01478/Cofinanciado FEDER; A.S.), DIAVIR (DTS19/00049/Cofinanciado FEDER, A.S.), Resvi-Omics (PI19/01039/Cofinanciado FEDER, A.S.), ReSVinext (PI16/01569/Cofinanciado FEDER, F.M.T.), Enterogen (PI19/01090/Cofinanciado FEDER, F.M.T.); Agencia Gallega para la Gestión del Conocimiento en Salud (ACIS): BI-BACVIR (PRIS-3, A.S.), and CovidPhy (SA 304 C, A.S.); Agencia Gallega de Innovación (GAIN): Grupos con Potencial de Crecimiento (IN607B 2020/08, A.S.), GEN-COVID (IN845D 2020/23, F.M.T.); Framework Partnership Agreement between the Consellería de Sanidad de la XUNTA de Galicia and GENVIP-IDIS - 2021–2024 (SERGAS-IDIS march 2021); and consorcio Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CB21/06/00103; F.M.T.). We also thank Aida Freire Valls from Nanostring for her support SI
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- 2022
5. Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae: Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU)
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Jefferies, Kimberley, Drysdale, Simon B, Robinson, Hannah, Clutterbuck, Elizabeth Ann, Blackwell, Luke, McGinley, Joseph, Lin, Gu-Lung, Galal, Ushma, Nair, Harish, Aerssens, Jeroen, Öner, Deniz, Langedijk, Annefleur, Bont, Louis, Wildenbeest, Joanne G, Martinon-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Nadel, Simon, Openshaw, Peter, Thwaites, Ryan, Widjojoatmodjo, Myra, Zhang, Linong, Nguyen, Thi Lien-Anh, Giaquinto, Carlo, Giordano, Giuseppe, Baraldi, Eugenio, Pollard, Andrew J, Campbell, Harry, Beutels, Philippe, Wildenbeest, Joanne, Bogaert, Debby, Pollard, Andrew, Klenerman, Paul, Sande, Charles, Snape, Matthew, Drysdale, Simon, Butler, Christopher, Diaz, Carlos, Molero, Eva, Wedzicha, Jadwicha, Martinón-Torres, Federico, Rodriguez-Tenreiro, Carmen, Heikkinen, Terho, Meijer, Adam, Sanders, Elisabeth, Fischer, Thea Kølsen, van den Berge, Maarten, Hackett, Judy, Dillon, Laura, Knirsch, Charles, Lopez, Antonio Gonzalez, Gallichan, Scott, Demont, Clarisse, Hillson, Eric, Rosen, Brian, and Investigators, Respiratory Syncytial Virus Consortium in Europe (RESCEU)
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Epigenomics ,Male ,Proteomics ,Respiratory syncytial virus ,Severity of Illness Index ,0302 clinical medicine ,Risk Factors ,Nasopharynx ,Surveys and Questionnaires ,Immunology and Allergy ,030212 general & internal medicine ,Respiratory Tract Infections ,Acute respiratory tract infection ,Netherlands ,media_common ,Respiratory tract infections ,Convalescence ,Viral Load ,3. Good health ,Europe ,Infectious Diseases ,Specimen collection ,Disease Progression ,Epigenetics ,Female ,Viral load ,Human ,medicine.medical_specialty ,media_common.quotation_subject ,Respiratory Syncytial Virus Infections ,03 medical and health sciences ,Internal medicine ,Severity of illness ,medicine ,Humans ,Metabolomics ,Transcriptomics ,business.industry ,Case-control study ,Infant ,medicine.disease ,Comorbidity ,United Kingdom ,030228 respiratory system ,Biomarkers ,Case-Control Studies ,Respiratory Syncytial Virus, Human ,Spain ,Transcriptome ,business - Abstract
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. Respiratory syncytial virus (RSV) is the leading viral pathogen associated with acute lower respiratory tract infection and hospitalization in children < 5 years of age worldwide. While there are known clinical risk factors for severe RSV infection, the majority of those hospitalized are previously healthy infants. There is consequently an unmet need to identify biomarkers that predict host response, disease severity, and sequelae. The primary objective is to identify biomarkers of severe RSV acute respiratory tract infection (ARTI) in infants. Secondary objectives include establishing biomarkers associated with respiratory sequelae following RSV infection and characterizing the viral load, RSV whole-genome sequencing, host immune response, and transcriptomic, proteomic, metabolomic and epigenetic signatures associated with RSV disease severity. Six hundred thirty infants will be recruited across 3 European countries: the Netherlands, Spain, and the United Kingdom. Participants will be recruited into 2 groups: (1) infants with confirmed RSV ARTI (includes upper and lower respiratory tract infections), 500 without and 50 with comorbidities; and (2) 80 healthy controls. At baseline, participants will have nasopharyngeal, blood, buccal, stool, and urine samples collected, plus complete a questionnaire and 14-day symptom diary. At convalescence (7 weeks ± 1 week post-ARTI), specimen collection will be repeated. Laboratory measures will be correlated with symptom severity scores to identify corresponding biomarkers of disease severity. CLINICAL TRIALS REGISTRATION: NCT03756766.
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- 2020
6. Low Sensitivity of BinaxNOW RSV in Infants
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Zuurbier, Roy P, Bont, Louis J, Langedijk, Annefleur C, Hamer, Mirjam, Korsten, Koos, Drysdale, Simon B, Snape, Matthew D, Robinson, Hannah, Pollard, Andrew J, Martinón-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Gómez-Carballa, Alberto, Dacosta-Urbieta, Ana Isabel, Heikkinen, Terho, Cunningham, Steve, van Houten, Marlies A, Wildenbeest, Joanne G, Zuurbier, Roy, Bont, Louis, Langedijk, Annefleur, van Houten, Marlies, Wildenbeest, Joanne, Drysdale, Simon, Snape, Matthew, Pollard, Andrew, Dacosta-Urbieta, Ana, Nair, Harish, Campbell, Harry, Openshaw, Peter, Beutels, Philippe, Molero, Eva, Meijer, Adam, Kølsen Fischer, Thea, van den Berge, Maarten, Giaquinto, Carlo, Esser, Mark, Knirsch, Charles, Leach, Amanda, Gallichan, Scott, Aerssens, Jeroen, Rosen, Brian, and Investigators, RESCEU
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Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Point-of-Care Systems ,Point-of-care testing ,Antibiotics ,Respiratory Syncytial Virus Infections ,Sensitivity and Specificity ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Pathology, Molecular ,Respiratory system ,Child ,Antigens, Viral ,Reference standards ,0303 health sciences ,Respiratory tract infections ,030306 microbiology ,business.industry ,Gold standard (test) ,Confidence interval ,3. Good health ,Hospitalization ,Infectious Diseases ,Case-Control Studies ,Child, Preschool ,Respiratory Syncytial Virus, Human ,Female ,Reagent Kits, Diagnostic ,business - Abstract
Background Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis. Methods We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard. Results One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%–16.5%) and a specificity of 100% (95% CI, 96.2%–100%). Sensitivity was low in all subgroups. Conclusions We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.
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- 2020
7. Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe—results from the PED-MERMAIDS multicentre case–control study
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Kohns Vasconcelos, Malte, primary, Loens, Katherine, additional, Sigfrid, Louise, additional, Iosifidis, Elias, additional, Epalza, Cristina, additional, Donà, Daniele, additional, Matheeussen, Veerle, additional, Papachristou, Savvas, additional, Roilides, Emmanuel, additional, Gijon, Manuel, additional, Rojo, Pablo, additional, Minotti, Chiara, additional, Da Dalt, Liviana, additional, Islam, Samsul, additional, Jarvis, Jessica, additional, Syggelou, Aggeliki, additional, Tsolia, Maria, additional, Nyirenda Nyang’wa, Maggie, additional, Keers, Sophie, additional, Renk, Hanna, additional, Gemmel, Anna-Lena, additional, D’Amore, Carmen, additional, Ciofi degli Atti, Marta, additional, Rodríguez-Tenreiro Sánchez, Carmen, additional, Martinón-Torres, Federico, additional, Burokienė, Sigita, additional, Goetghebuer, Tessa, additional, Spoulou, Vana, additional, Riordan, Andrew, additional, Calvo, Cristina, additional, Gkentzi, Despoina, additional, Hufnagel, Markus, additional, Openshaw, Peter J, additional, de Jong, Menno D, additional, Koopmans, Marion, additional, Goossens, Herman, additional, Ieven, Margareta, additional, Fraaij, Pieter L A, additional, Giaquinto, Carlo, additional, Bielicki, Julia A, additional, Horby, Peter, additional, and Sharland, Michael, additional
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- 2021
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8. Improving Influenza Vaccine Acceptance in Children Leveraging on COVID-19 Vaccination Lessons
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Ares-Gomez, Sonia, Mallah, Narmeen, Pardo-Seco, Jacobo, Nartallo-Penas, Victoria, Mirás-Carballal, Susana, Rodriguez-Tenreiro-Sánchez, Carmen, Rivero-Calle, Irene, Piñeiro-Sotelo, Marta, Durán-Parrondo, Carmen, and Martinón-Torres, Federico
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- 2023
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9. Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe
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Wildenbeest, Joanne G, Zuurbier, Roy P, Korsten, Koos, van Houten, Marlies A, Billard, Marie N, Derksen-Lazet, Nicole, Snape, Matthew D, Drysdale, Simon B, Robinson, Hannah, Pollard, Andrew J, Heikkinen, Terho, Cunningham, Steve, Leach, Amanda, Martinón-Torres, Federico, Rodríguez-Tenreiro Sánchez, Carmen, Gómez-Carballa, Alberto, Bont, Louis J, Wildenbeest, Joanne, Zuurbier, Roy, van Houten, Marlies, Billard, Marie, Bont, Louis, Drysdale, Simon, Snape, Matthew, Pollard, Andrew, Sánchez, Carmen Rodríguez-Tenreiro, Nair, Harish, Campbell, Harry, Openshaw, Peter, Beutels, Philippe, Molero, Eva, Meijer, Adam, Sanders, Elisabeth, Fischer, Thea Kølsen, van den Berge, Maarten, Giaquinto, Carlo, Esser, Mark, Knirsch, Charles, Gallichan, Scott, Aerssens, Jeroen, and Rosen, Brian
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Pediatrics ,medicine.medical_specialty ,viruses ,Respiratory Syncytial Virus Infections ,Disease ,Virus ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,030225 pediatrics ,Respiratory Syncytial Virus Vaccines ,Humans ,Immunology and Allergy ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Respiratory system ,Prospective cohort study ,Respiratory Tract Infections ,Acute respiratory tract infection ,Cardiopulmonary disease ,business.industry ,Incidence ,Infant ,3. Good health ,Europe ,Hospitalization ,Clinical trial ,Infectious Diseases ,Respiratory Syncytial Virus, Human ,Cohort ,business ,Biomarkers - Abstract
BackgroundRespiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants hospitalized with RSV are previously healthy. Various vaccines and therapeutics are under development and expected to be available in the near future. To inform the use of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in Europe. We will prospectively follow-up a birth cohort to obtain incidence data on RSV acute respiratory tract infection (ARTI).MethodsMulticenter prospective study of a birth cohort consisting of 10 000 healthy infants, recruited during 3 consecutive years. RSV associated hospitalization in the first year of life will be determined by questionnaires and hospital chart reviews. A nested cohort of 1000 infants will be actively followed. In case of ARTI, a respiratory sample will be collected for RSV molecular diagnosis.ResultsThe primary outcome is the incidence rate of RSV-associated hospitalization in the first year of life. In the active cohort the primary outcome is RSV associated ARTI and MA-ARTI.ConclusionsWe will provide key information to fill the gaps in knowledge about the burden of RSV disease in healthy infants.Clinical Trials RegistrationNCT03627572.
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- 2020
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10. New perspectives for hexavalent vaccines
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Obando-Pacheco, Pablo, primary, Rivero-Calle, Irene, additional, Gómez-Rial, José, additional, Rodríguez-Tenreiro Sánchez, Carmen, additional, and Martinón-Torres, Federico, additional
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- 2018
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11. Vacunas antimeningocócicas. Situación epidemiológica mundial y estrategias de prevención mediante la vacunación
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Rivero Calle, Irene, Rodriguez-Tenreiro Sánchez, Carmen, and Martinón-Torres, Federico
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- 2015
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12. Development and Validation of a New Clinical Scale for Infants with Acute Respiratory Infection: The ReSVinet Scale
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Justicia Grande, Antonio, Pardo Seco, Jacobo José, Cebey López, Miriam, Vilanova Trillo, Lucía, Gómez Carballa, Alberto, Rivero Calle, Irene, Puente-Puig, María, Curros-Novo, Carmen, Gómez Rial, Jose, Salas Ellacuriaga, Antonio, Martinon-Torres, José María, Redondo-Collazo, Lorenzo, Rodríguez-Tenreiro Sánchez, Carmen, Martinón Torres, Federico, Respiratory Syncytial Virus network (ReSVinet), and Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría
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Parents ,Pediatrics ,Pulmonology ,Medical Doctors ,Health Care Providers ,lcsh:Medicine ,Cohort Studies ,Families ,0302 clinical medicine ,Surveys and Questionnaires ,Outpatients ,Medicine and Health Sciences ,Medicine ,030212 general & internal medicine ,lcsh:Science ,Children ,Respiratory Tract Infections ,Multidisciplinary ,Respiratory tract infections ,Medical record ,Respiratory infection ,3. Good health ,Professions ,Chemistry ,Physical Sciences ,Acute Disease ,Bronchiolitis ,Infants ,Research Article ,Chemical Elements ,Cohort study ,medicine.medical_specialty ,Patients ,Scale (ratio) ,Pediatric Pulmonology ,03 medical and health sciences ,Cronbach's alpha ,Physicians ,030225 pediatrics ,Humans ,business.industry ,lcsh:R ,Infant ,Reproducibility of Results ,medicine.disease ,Health Care ,Oxygen ,Age Groups ,People and Places ,Respiratory Infections ,lcsh:Q ,Population Groupings ,business ,Kappa - Abstract
Background and Aims A properly validated scoring system allowing objective categorization of infants with acute respiratory infections (ARIs), avoiding the need for in-person assessment and that could also be used by non-health professionals is currently not available. We aimed to develop a new clinical assessment scale meeting these specifications. Methods We designed a clinical scale (ReSVinet scale) based on seven parameters (feeding intolerance, medical intervention, respiratory difficulty, respiratory frequency, apnoea, general condition, fever) that were assigned different values (from 0 to 3) for a total of 20 points.170 children under two years of age with ARI were assessed independently by three pediatricians using this scale. Parents also evaluated their offspring with an adapted version of the scale in a subset of 61 cases. The scale was tested for internal consistency (Cronbach’s alpha), Pearson correlation coefficient for the items in the scale, inter-observer reliability (kappa index) and floor-ceiling effect. Results Internal consistency was good for all the observers, with the lowest Cronbach’s alpha being 0.72. There was a strong correlation between the investigators (r-value ranged 0.76–0.83) and also between the results obtained by the parents and the investigators(r = 0.73). Light’s kappa for the observations of the three investigators was 0.74. Weighted kappa in the group evaluated by the parents was 0.73. The final score was correlated with length of hospital stay, PICU admission and Wood-Downes Score. Conclusions The ReSVinet scale may be useful and reliable in the evaluation of infants with ARI, particularly acute bronchiolitis, even with data obtained from medical records and when employed by parents. Although further studies are necessary, ReSVinet scale already complies with more score validation criteria than the vast majority of the alternatives currently available and used in the clinical practice This work was supported by the Spanish Government (Research Program Health Research Fund – [http://www.gendres.org] (FIS; PI10/00540 y PI13/02382) National Plan I + D + I and FEDER funds) and Regional Galician funds (Promotion of Research Project 10 PXIB 918 184 PR) (FMT), and Ministerio de Ciencia e Innovación (SAF2011-26983) and the Plan Galego IDT, Xunta de Galicia (EM 2012/045) (AS). MC’s research activities have been supported by grants from Instituto de Investigación Sanitaria de Santiago de Compostela. FMT’s research activities have been supported by grants from Instituto Carlos III (Intensificación de la actividad investigadora- ISCIII/INT14/00245/ Cofinanciado FEDER), Spanish National Plan I + D + i and FEDER funds. Investigators received funding from the European Union’s Seventh Framework Program under ECGA no. 279185 (EUCLIDS – [http://www.euclids-project.eu]) during the production of this paper. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript SI
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- 2016
13. Vacuna universal frente a meningococo B
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Martinón Torres, Federico and Rodríguez-Tenreiro Sánchez, Carmen
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- 2011
14. Hidrogeles de ciclodextrinas co-reticulados e interpenetrados para liberación controlada de fármacos
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Rodríguez-Tenreiro Sánchez, Carmen, Álvarez Lorenzo, Carmen, Torres Labandeira, Juan José, Alvarez Lorenzo, Carmen, 1970, Torres Labandeira, Juan José, 1962, and Álvarez Lorenzo, Carmen Isabel
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Ciclodextrinas nas técnicas farmacéuticas -- Teses e escritos académicos ,Medicamentos -- Cesión controlada -- Teses e escritos académicos - Published
- 2007
15. Whole exome sequencing identifies new susceptibility candidates underlying community-acquired pneumonia.
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Pardo-Seco J, Viz-Lasheras S, Bello X, Gómez-Carballa A, Camino-Mera A, Pischedda S, Currás-Tuala MJ, Rivero-Calle I, Dacosta-Urbieta A, Caamaño-Viña F, Rodríguez-Tenreiro Sánchez C, Cifuentes I, Méndez C, Khor CC, Martinón-Torres F, and Salas A
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- 2023
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16. [Ethics Committee experience during COVID-19 emergency. A brief report.]
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Bugarín González R, Romero-Yuste SM, López Vázquez PM, Casariego Rosón J, Carballeda Feijóo N, Cruz Del Río JM, Cueva Bañuelos JF, Fernández Rial JÁ, Fernández Trisac JL, Ferreira Díaz MJ, Millán Calenti RÁ, Pía Morandeira A, Prado Casal J, Rodríguez-Tenreiro Sánchez C, Santos García D, Vázquez Lago JM, Verdejo González MA, and Zarra Ferro I
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- Betacoronavirus, COVID-19, Humans, Informed Consent, Pandemics, SARS-CoV-2, Spain, Coronavirus Infections epidemiology, Ethics Committees, Research, Pneumonia, Viral epidemiology, Research Design standards, Workflow
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Objective: The health crisis caused by COVID-19 required the prompt launch of research in order to generate scientific evidence pertaining to the new disease oriented to control its devastating effects and continuous spread. Therefore, it was essential to adapt the work flow of Research Ethics Committees, to prioritize and to accelerate the evaluation of projects related to this disease., Methods: This work analyses the evaluation conducted by our Regional Ethics Committees during the initial period of the health emergency (between 13th March and 28th May 2020)., Results: 81 research projects were evaluated, 73 of them of regional scope (62 single-centre), 4 national and 4 international. 57 projects obtained a favourable opinion, 4 were withdrawn by the sponsors, 6 did not require ethics approval and 14 did not respond to the clarifications requested up to the date of the study's closure., Conclusions: The most important research procedures to be analysed in this context are those related to the methodology and informed consent process. It is also essential to address aspects related to the privacy of personal data, and to take into account the workload of the researchers. As an improvement proposal, we think that greater collaboration between the different research teams should be encourage to obtain more robust results.
- Published
- 2020
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