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2. Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non–muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics

Author

Subiela, José Daniel, Krajewski, Wojciech, González-Padilla, Daniel A., Laszkiewicz, Jan, Taborda, Javier, Aumatell, Júlia, Sanchez Encinas, Miguel, Basile, Giuseppe, Moschini, Marco, Caño-Velasco, Jorge, Lopez Perez, Enrique, Del Olmo Durán, Pedro, Gallioli, Andrea, Tukiendorf, Andrzej, D'Andrea, David, Yuen-Chun Teoh, Jeremy, Serna Céspedes, Alejandra, Pichler, Renate, Afferi, Luca, Del Giudice, Francesco, Gomez Rivas, Juan, Albisinni, Simone, Soria, Francesco, Ploussard, Guillaume, Mertens, Laura S., Rajwa, Paweł, Laukhtina, Ekaterina, Pradere, Benjamin, Tully, Karl, Guerrero-Ramos, Félix, Rodríguez-Faba, Óscar, Alvarez-Maestro, Mario, Dominguez-Escrig, Jose Luis, Szydełko, Tomasz, Gomez Dos Santos, Victoria, Jiménez Cidre, Miguel Ángel, and Burgos Revilla, Francisco Javier

Published
2024
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6. Long-term Recurrence and Progression Patterns in a Contemporary Series of Patients with Carcinoma In Situ of the Bladder With or Without Associated Ta/T1 Disease Treated with Bacillus Calmette-Guérin: Implications for Risk-adapted Follow-up

Author

Subiela, José Daniel, Rodríguez Faba, Óscar, Aumatell, Júlia, Gonzalez-Padilla, Daniel Antonio, Rosales Bordes, Antonio, Huguet, Jorge, Krajewski, Wojciech, Algaba, Ferran, López Curtis, David, Brasero Burgos, Jennifer, Sánchez González, Álvaro, Jiménez Cidre, Miguel Ángel, Burgos Revilla, Francisco Javier, Breda, Alberto, and Palou, Joan

Published
2023
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8. Oncological and Renal Function Outcomes in Patients Who Underwent Simultaneous Radical Cystectomy and Nephroureterectomy for Synchronous or Metachronous Panurothelial Carcinoma

Author

Subiela, José Daniel, González-Padilla, Daniel A., Huguet, Jorge, Aumatell, Júlia, Rodríguez-Faba, Oscar, Krajewski, Wojciech, Feliu, Alejandro Hevia, Mínguez, Cesar, Plaza, José López, Artiles Medina, Alberto, Gajate, Pablo, Jiménez Cidre, Miguel Ángel, Burgos Revilla, Javier, Breda, Alberto, and Palou, Joan

Published
2023
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12. Impact of Metabolic Diseases, Drugs, and Dietary Factors on Prostate Cancer Risk, Recurrence, and Survival: A Systematic Review by the European Association of Urology Section of Oncological Urology

Author

Campi, Riccardo, Brookman-May, Sabine D., Subiela Henríquez, Jose Daniel, Akdoğan, Bülent, Brausi, Maurizio, Klatte, Tobias, Langenhuijsen, Johan F., Linares-Espinos, Estefania, Marszalek, Martin, Roupret, Morgan, Stief, Christian G., Volpe, Alessandro, Minervini, Andrea, and Rodriguez-Faba, Oscar

Published
2019
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13. Latest Evidence on the Impact of Smoking, Sports, and Sexual Activity as Modifiable Lifestyle Risk Factors for Prostate Cancer Incidence, Recurrence, and Progression: A Systematic Review of the Literature by the European Association of Urology Section of Oncological Urology (ESOU)

Author

Brookman-May, Sabine D., Campi, Riccardo, Henríquez, Jose D.S., Klatte, Tobias, Langenhuijsen, Johan F., Brausi, Maurizio, Linares-Espinós, Estefania, Volpe, Alessandro, Marszalek, Martin, Akdogan, Bulent, Roll, Christina, Stief, Christian G., Rodriguez-Faba, Oscar, and Minervini, Andrea

Published
2019
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14. Does the Unexpected Presence of Non-organ-confined Disease at Final Pathology Undermine Cancer Control in Patients with Clinical T1N0M0 Renal Cell Carcinoma Who Underwent Partial Nephrectomy?

Author

Capitanio, Umberto, Stewart, Grant D., Klatte, Tobias, Akdogan, Bulent, Roscigno, Marco, Marszalek, Martin, Dell’Oglio, Paolo, Zaffuto, Emanuele, Rodriguez Faba, Oscar, Salagierski, Maciej, Lingard, James, Carini, Marco, Ouzaid, Idir, Mir, Maria Carmen, Montorsi, Francesco, Da Pozzo, Luigi Filippo, Stief, Christian, Minervini, Andrea, and Brookman-May, Sabine D.

Published
2018
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15. Impact of Microscopic Wall Invasion of the Renal Vein or Inferior Vena Cava on Cancer-specific Survival in Patients with Renal Cell Carcinoma and Tumor Thrombus: A Multi-institutional Analysis from the International Renal Cell Carcinoma-Venous Thrombus Consortium

Author

Rodriguez Faba, Oscar, Linares, Estefania, Tilki, Derya, Capitanio, Umberto, Evans, Christopher P., Montorsi, Francesco, Martínez-Salamanca, Juan I., Libertino, John, Gontero, Paolo, and Palou, Joan

Published
2018
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22. Cardiopulmonary Bypass has No Significant Impact on Survival in Patients Undergoing Nephrectomy and Level III-IV Inferior Vena Cava Thrombectomy: Multi-Institutional Analysis

Author

Nguyen, Hao G., Tilki, Derya, Dall’Era, Marc A., Durbin-Johnson, Blythe, Carballido, Joaquín A., Chandrasekar, Thenappan, Chromecki, Thomas, Ciancio, Gaetano, Daneshmand, Siamak, Gontero, Paolo, Gonzalez, Javier, Haferkamp, Axel, Hohenfellner, Markus, Huang, William C., Linares Espinós, Estefania, Mandel, Philipp, Martinez-Salamanca, Juan I., Master, Viraj A., McKiernan, James M., Montorsi, Francesco, Novara, Giacomo, Pahernik, Sascha, Palou, Juan, Pruthi, Raj S., Rodriguez-Faba, Oscar, Russo, Paul, Scherr, Douglas S., Shariat, Shahrokh F., Spahn, Martin, Terrone, Carlo, Vergho, Daniel, Wallen, Eric M., Xylinas, Evanguelos, Zigeuner, Richard, Libertino, John A., and Evans, Christopher P.

Published
2015
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23. Impact of Synchronous Metastasis Distribution on Cancer Specific Survival in Renal Cell Carcinoma after Radical Nephrectomy with Tumor Thrombectomy

Author

Tilki, Derya, Hu, Brian, Nguyen, Hao G., Dall’Era, Marc A., Bertini, Roberto, Carballido, Joaquín A., Chandrasekar, Thenappan, Chromecki, Thomas, Ciancio, Gaetano, Daneshmand, Siamak, Gontero, Paolo, Gonzalez, Javier, Haferkamp, Axel, Hohenfellner, Markus, Huang, William C., Koppie, Theresa M., Linares, Estefania, Lorentz, C. Adam, Mandel, Philipp, Martinez-Salamanca, Juan I., Master, Viraj A., Matloob, Rayan, McKiernan, James M., Mlynarczyk, Carrie M., Montorsi, Francesco, Novara, Giacomo, Pahernik, Sascha, Palou, Juan, Pruthi, Raj S., Ramaswamy, Krishna, Rodriguez Faba, Oscar, Russo, Paul, Shariat, Shahrokh F., Spahn, Martin, Terrone, Carlo, Thieu, William, Vergho, Daniel, Wallen, Eric M., Xylinas, Evanguelos, Zigeuner, Richard, Libertino, John A., and Evans, Christopher P.

Published
2015
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26. Long-term Recurrence and Progression Patterns in a Contemporary Series of Patients with Carcinoma In Situ of the Bladder With or Without Associated Ta/T1 Disease Treated with Bacillus Calmette-Guérin: Implications for Risk-adapted Follow-up

Author

Subiela, José Daniel, primary, Rodríguez Faba, Óscar, additional, Aumatell, Júlia, additional, Gonzalez-Padilla, Daniel Antonio, additional, Rosales Bordes, Antonio, additional, Huguet, Jorge, additional, Krajewski, Wojciech, additional, Algaba, Ferran, additional, López Curtis, David, additional, Brasero Burgos, Jennifer, additional, Sánchez González, Álvaro, additional, Jiménez Cidre, Miguel Ángel, additional, Burgos Revilla, Francisco Javier, additional, Breda, Alberto, additional, and Palou, Joan, additional

Published
2022
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27. Impact of lymph node dissection at the time of radical nephrectomy with tumor thrombectomy on oncological outcomes: Results from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC)

Author

Tilki, Derya, Chandrasekar, Thenappan, Capitanio, Umberto, Ciancio, Gaetano, Daneshmand, Siamak, Gontero, Paolo, Gonzalez, Javier, Haferkamp, Axel, Hohenfellner, Markus, Huang, William C., Linares Espinós, Estefania, Lorentz, Adam, Martinez-Salamanca, Juan I., Master, Viraj A., McKiernan, James M., Montorsi, Francesco, Novara, Giacomo, Pahernik, Sascha, Palou, Juan, Pruthi, Raj S., Rodriguez-Faba, Oscar, Russo, Paul, Scherr, Douglas S., Shariat, Shahrokh F., Spahn, Martin, Terrone, Carlo, Vera-Donoso, Cesar, Zigeuner, Richard, Libertino, John A., and Evans, Christopher P.

Published
2018
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28. Nomograms including UBC® Rapid Test to detect primary bladder cancer based on a multicenter data set

Author

Meisl, Christina J., Karakiewicz, Pierre I., Einarsson, Roland, Koch, Stefan, Hallmann, Steffen, Weiß, Sarah, Hemdan, Tammer, Malmström, Per-Uno, Styrke, Johan, Sherif, Amir, Hasan, Mudhar N., Pichler, Renate, Tulchiner, Gennadi, Palou, Joan, Rodríguez Faba, Óscar, Hennenlotter, Jörg, Stenzl, Arnulf, Ritter, René, Niegisch, Günter, Grunewald, Camilla M., Schlomm, Thorsten, Friedersdorff, Frank, Barski, Dimitri, Otto, Thomas, Gössl, Andreas, Arndt, Christian, Esuvaranathan, Kesavan, Kesavan, Nisha R., Zhijiang, Zang, Kramer, Mario W., Hennig, Martin J. P., Ecke, Thorsten H., Meisl, Christina J., Karakiewicz, Pierre I., Einarsson, Roland, Koch, Stefan, Hallmann, Steffen, Weiß, Sarah, Hemdan, Tammer, Malmström, Per-Uno, Styrke, Johan, Sherif, Amir, Hasan, Mudhar N., Pichler, Renate, Tulchiner, Gennadi, Palou, Joan, Rodríguez Faba, Óscar, Hennenlotter, Jörg, Stenzl, Arnulf, Ritter, René, Niegisch, Günter, Grunewald, Camilla M., Schlomm, Thorsten, Friedersdorff, Frank, Barski, Dimitri, Otto, Thomas, Gössl, Andreas, Arndt, Christian, Esuvaranathan, Kesavan, Kesavan, Nisha R., Zhijiang, Zang, Kramer, Mario W., Hennig, Martin J. P., and Ecke, Thorsten H.

Abstract

Objectives: To evaluate the clinical utility of the urinary bladder cancer antigen UBC® Rapid Test for the diagnosis of bladder cancer (BC) and to develop and validate nomograms to identify patients at high-risk of primary BC. Patients and methods: Data from 1,787 patients from 13 participating centers tested between 2012 and 2020, including 763 patients with BC, were analyzed. Urine samples were analyzed with the UBC® Rapid Test. The nomograms were developed using data from 320 patients and externally validated using data from 274 patients. The diagnostic accuracy of the UBC® Rapid Test was evaluated using receiver operating characteristics analysis. Brier scores and calibration curves were chosen for validation. Biopsy-proven BC was predicted using multivariate logistic regression. Results: The sensitivity, specificity, and area under the curve for the UBC® Rapid Test were 46.4%, 75.5%, and 0.61 (95% CI: 0.58–0.64) for low-grade (LG-) BC, and 70.5%, 75.5%, and 0.73 (95% CI: 0.70–0.76) for high-grade (HG-) BC, respectively. Age, UBC® Rapid Test results, smoking status, and hematuria were identified as independent predictors of primary BC. After external validation, nomograms based on these predictors resulted in an area under the curve of 0.79 (95% CI: 0.72–0.87) and 0.95 (95% CI: 0.92–0.98) in predicting LG-BC and HG-BC, respectively, showing excellent calibration associated with a higher net benefit than the UBC® Rapid Test alone for low and medium risk levels in decision curve analysis. An R Shiny app allows the results to be explored interactively and can be accessed at www.blucab-index.net. Conclusion: The UBC® Rapid Test alone has limited clinical utility for predicting the presence of BC. However, its combined use with BC risk factors including age, smoking status, and hematuria provides a fast, highly accurate, and non-invasive tool for screening patients for primary LG-BC and especially primary HG-BC.

Published
2022
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32. Nomograms including the UBC® Rapid test to detect primary bladder cancer based on a multicentre dataset

Author

Meisl, Christina J., primary, Karakiewicz, Pierre I., additional, Einarsson, Roland, additional, Koch, Stefan, additional, Hallmann, Steffen, additional, Weiß, Sarah, additional, Hemdan, Tammer, additional, Malmström, Per‐Uno, additional, Styrke, Johan, additional, Sherif, Amir, additional, Hasan, Mudhar N., additional, Pichler, Renate, additional, Tulchiner, Gennadi, additional, Palou, Joan, additional, Rodríguez Faba, Óscar, additional, Hennenlotter, Jörg, additional, Stenzl, Arnulf, additional, Ritter, René, additional, Niegisch, Günter, additional, Grunewald, Camilla M., additional, Schlomm, Thorsten, additional, Friedersdorff, Frank, additional, Barski, Dimitri, additional, Otto, Thomas, additional, Gössl, Andreas, additional, Arndt, Christian, additional, Esuvaranathan, Kesavan, additional, Kesavan, Nisha R., additional, Zhijiang, Zang, additional, Kramer, Mario W., additional, Hennig, Martin J. P., additional, and Ecke, Thorsten H., additional

Published
2022
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35. Nomograms including the UBC® Rapid test to detect primary bladder cancer based on a multicentre dataset.

Author

Meisl, Christina J., Karakiewicz, Pierre I., Einarsson, Roland, Koch, Stefan, Hallmann, Steffen, Weiß, Sarah, Hemdan, Tammer, Malmström, Per‐Uno, Styrke, Johan, Sherif, Amir, Hasan, Mudhar N., Pichler, Renate, Tulchiner, Gennadi, Palou, Joan, Rodríguez Faba, Óscar, Hennenlotter, Jörg, Stenzl, Arnulf, Ritter, René, Niegisch, Günter, and Grunewald, Camilla M.

Subjects
NOMOGRAPHY (Mathematics), ANTIGEN analysis, BLADDER cancer, BLADDER, DECISION making, MEDICAL screening
Abstract

Objectives: To evaluate the clinical utility of the urinary bladder cancer antigen test UBC® Rapid for the diagnosis of bladder cancer (BC) and to develop and validate nomograms to identify patients at high risk of primary BC. Patients and Methods: Data from 1787 patients from 13 participating centres, who were tested between 2012 and 2020, including 763 patients with BC, were analysed. Urine samples were analysed with the UBC® Rapid test. The nomograms were developed using data from 320 patients and externally validated using data from 274 patients. The diagnostic accuracy of the UBC® Rapid test was evaluated using receiver‐operating characteristic curve analysis. Brier scores and calibration curves were chosen for the validation. Biopsy‐proven BC was predicted using multivariate logistic regression. Results: The sensitivity, specificity, and area under the curve for the UBC® Rapid test were 46.4%, 75.5% and 0.61 (95% confidence interval [CI] 0.58–0.64) for low‐grade (LG) BC, and 70.5%, 75.5% and 0.73 (95% CI 0.70–0.76) for high‐grade (HG) BC, respectively. Age, UBC® Rapid test results, smoking status and haematuria were identified as independent predictors of primary BC. After external validation, nomograms based on these predictors resulted in areas under the curve of 0.79 (95% CI 0.72–0.87) and 0.95 (95% CI: 0.92–0.98) for predicting LG‐BC and HG‐BC, respectively, showing excellent calibration associated with a higher net benefit than the UBC® Rapid test alone for low and medium risk levels in decision curve analysis. The R Shiny app allows the results to be explored interactively and can be accessed at www.blucab‐index.net. Conclusion: The UBC® Rapid test alone has limited clinical utility for predicting the presence of BC. However, its combined use with BC risk factors including age, smoking status and haematuria provides a fast, highly accurate and non‐invasive tool for screening patients for primary LG‐BC and especially primary HG‐BC. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Contemporary outcomes of bladder carcinoma in situ treated with an adequate bacille Calmette–Guérin immunotherapy.

Author

Subiela, José Daniel, Rodríguez Faba, Óscar, Aumatell, Júlia, Calderón, Julio, Mercadé, Asier, Balañà, Josep, Esquinas, Cristina, Algaba, Ferran, Breda, Alberto, and Palou, Joan

Subjects
*CARCINOMA in situ, *BLADDER, *BLADDER cancer, *CYSTOSCOPY, *TUBERCULIN test, *CANCER patients, *PROGNOSIS, *IMMUNOTHERAPY
Abstract

Objective: To assess whether bacillus Calmette–Guérin (BCG) responsiveness after initiation of an adequate BCG treatment (at least five of six instillations of induction and at least two of three instillations of maintenance) impacts oncological outcomes in patients with carcinoma in situ (CIS) of the bladder treated with BCG immunotherapy. Patients and Methods: Data were available for 193 patients with bladder CIS with or without associated cTa/cT1 disease who received an adequate BCG treatment between 2008 and 2015. Bladder biopsies were taken at 6 months and patients were then stratified as either BCG responsive (negative biopsies) or BCG unresponsive (positive biopsies). Inverse probability weighting (IPW)‐adjusted Kaplan–Meier and IPW‐adjusted Cox regression were performed to compare progression‐free survival (PFS), radical cystectomy‐free survival (RCFS), overall survival OS, and cancer‐specific survival (CSS) in the two groups. Results and Limitations: Comparing the BCG‐responsive and BCG‐unresponsive groups, IPW‐adjusted Kaplan–Meier analysis revealed, respectively, a median (interquartile range) of PFS of 9 (5–15) vs 48.5 (28–77) months (P = 0.001), a RCFS of 11 (9–15) vs 49 (24–76) months (P < 0.001), and a CSS of 25 (13–60) vs 109 (78–307) months (P = 0.004). On IPW‐adjusted Cox regression analysis, BCG‐unresponsive patients had a worse PFS (hazard ratio [HR] 3.40, 95% confidence interval [CI] 1.59–7.27), RCFS (HR 3.52, 95% CI 1.77–7), and CSS (HR 4.42, 95% CI 1.95–10.01). We found no significant differences for OS. Conclusion: Using an IPW method we found that lack of response after initiation of an adequate BCG treatment has prognostic implications beyond identification of complete response in patients with CIS. BCG‐unresponsive patients, satisfying the novel definition of BCG unresponsive, showed a poor PFS, RCFS, and CSS. In this setting, the patients should be counselled regarding RC as a first option or enrolled in a clinical trial if they refuse RC or are unfit for surgery. [ABSTRACT FROM AUTHOR]

Published
2022
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45. MP59-02 CHARACTERISTICS AND PERIOPERATIVE OUTCOMES FOLLOWING SURGICAL TREATMENT FOR RENAL CELL CARCINOMA IN VERY ELDERLY PATIENTS (≥75 YEARS): DATA FROM THE LATIN AMERICAN RENAL CANCER GROUP (LARCG)

Author

Garza-Gangemi, Adrian M., Castillejos-Molina, Ricardo A., Gueglio Saccone, Mario Guillermo, Jurado, Alberto, Meza Montoya, Luis, Scorticati, Carlos, Lopez, Matias, da Costa, Walter H., Yandian, Juan, Ubillos, Luis, Glina, Sidney, Tobias-Machado, Marcos, Rodríguez Faba, Oscar, Ameri, Carlos A., Nolazco, Alejandro, Martinez, Pablo, Carvalhal, Gustavo, Cauduro, Carolina, Barrios, Pablo M., Bengio, Ruben, Arribillaga, Leandro, Langenhin, Raul, Muguruza, Diego, Campos Salcedo, José G., Bravo Castro, Edgar I., Mingote, Pablo, Ginastar, Nicolas, Puente, Roberto, Decia, Ricardo, Cardoso Guimarães, Gustavo, Palau, Joan, Abreu-Clavijo, Diego, Zequi, Stenio de Cassio, and Rodríguez-Covarrubias, Francisco

Published
2018
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46. MP48-17 OUTCOMES OF PARTIAL VERSUS RADICAL NEPHRECTOMY IN OCTOGENARIAN PATIENTS: RESULTS FROM THE RESURGE PROJECT

Author

Antonelli, Alessandro, Palumbo, Carlotta, Furlan, Maria, Pavan, Nicola, Mir, Carmen, Breda, Alberto, Linares, Estefania, Takagi, Toshio, Rha, Koon, Porpiglia, Francesco, Maurer, Tobias, Yang, Bo, Umari, Paolo, Long, Jean-Alexandre, De Nunzio, Cosimo, Tracey, Andrew, Ferro, Matteo, Micali, Salvatore, Lima, Estevão, Aguilera, Alfredo, Tanabe, Kazunari, Raheem, Ali, Bertolo, Riccardo, Amiel, Thomas, Zang, Chao, Fiard, Gaelle, Tubaro, Andrea, De Cobelli, Ottavio, Bevilacqua, Luigi, Torres, Joao, Bove, Pierluigi, Schips, Luigi, Castellucci, Roberto, Perdona, Sisto, Quarto, Giuseppe, Celia, Antonio, De Concilio, Bernardino, Trombetta, Carlo, Silvestri, Tommaso, Mottrie, Alexandre, Palou, Joan, Rodriguez Faba, Oscar, Capitanio, Umberto, Larcher, Alessandro, Montorsi, Francesco, Derweesh, Ithaar, Bindayi, Ahmet, Hamilton, Zachary, and Autorino, Riccardo

Published
2018
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47. MP48-07 PATTERNS AND PREDICTORS OF RESECTION TECHNIQUES DURING PARTIAL NEPHRECTOMY FOR T1 RENAL MASSES: RESULTS OF A MULTICENTRE PROSPECTIVE COHORT STUDY FROM THE SURFACE-INTERMEDIATE-BASE (SIB) MARGIN SCORE INTERNATIONAL CONSORTIUM (IDEAL PHASE 2B)

Author

Kutikov, Alexander, Campi, Riccardo, Lane, Brian, De Cobelli, Ottavio, Sanguedolce, Francesco, Villeda Sandoval, Christian, Hatzichristodoulou, Georgios, Mari, Andrea, Antonelli, Alessandro, Rodriguez Faba, Oscar, Langenhuijsen, Hans, Klatte, Tobias, Roscigno, Marco, Akdogan, Bulent, Karakoyunlu, Nihat, Marszalek, Martin, Capitanio, Umberto, Volpe, Alessandro, Brookman-May, Sabine, Uzzo, Robert, Carini, Marco, and Minervini, Andrea

Published
2018
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49. Unlocking the Potential of Adequate Bacillus Calmette-Guérin Immunotherapy in Very-high-risk Non–muscle-invasive Bladder Carcinoma: A Multicenter Analysis of Oncological Outcomes and Risk Dynamics

Author

Daniel Subiela, José, Krajewski, Wojciech, González-Padilla, Daniel A., Laszkiewicz, Jan, Taborda, Javier, Aumatell, Júlia, Sanchez Encinas, Miguel, Basile, Giuseppe, Moschini, Marco, Caño-Velasco, Jorge, Lopez Perez, Enrique, Del Olmo Durán, Pedro, Gallioli, Andrea, Tukiendorf, Andrzej, D'Andrea, David, Yuen-Chun Teoh, Jeremy, Serna Céspedes, Alejandra, Pilcher, Renate, Afferi, Luca, Del Giudice, Francesco, Gomez Rivas, Juan, Albisinni, Simone, Soria, Francesco, Ploussard, Guillaume, Mertens, Laura S., Rajwa, Paweł, Laukhtina, Ekaterina, Pradere, Benjamin, Tully, Karl, Guerrero-Ramos, Félix, Rodríguez-Faba, Óscar, Alvarez-Maestro, Mario, Luis Dominguez-Escrig, Jose, Szydełko, Tomasz, Gomez Dos Santos, Victoria, Ángel Jiménez Cidre, Miguel, and Javier Burgos Revilla, Francisco

Abstract

The patients with very high-risk (VHR) non–muscle-invasive bladder carcinoma (NMIBC) who receive adequate bacillus Calmette-Guérin (BCG) therapy experience a more favorable prognosis than previously reported by the European Association of Urology risk groups. This highlights that there is a role for BCG immunotherapy in this patient cohort, particularly for those who maintain sustained BCG response in the long term. Our study does not provide enough evidence to support BCG as the first-line therapy for all VHR patients. Therefore, it should be considered cautiously on a case-by-case basis. The prognosis of patients with VHR NMIBC improves over time. Thus, the probability of recurrence and progression is sufficiently low when patients remain disease free for 4 yr to justify less strict follow-up.

Published
2024
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