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8. Porto-Sinusoidal Vascular Disorder

Author

Rodrigues, Susana G., Montani, Matteo, De Gottardi, Andrea, Valla, Dominique, editor, Garcia-Pagan, Juan Carlos, editor, De Gottardi, Andrea, editor, and Rautou, Pierre-Emmanuel, editor

Published
2022
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16. Improving primary prophylaxis of variceal bleeding by adapting therapy to the clinical stage of cirrhosis. A competing‐risk meta‐analysis of individual participant data.

Author

Villanueva, Càndid, Sapena, Victor, Lo, Gin‐Ho, Seo, Yeon Seok, Shah, Hasnain Ali, Singh, Virendra, Tripathi, Dhiraj, Schepke, Michael, Gheorghe, Cristian, Bonilha, Daniell Q., Jutabha, Rome, Wang, Huay‐Min, Rodrigues, Susana G., Brujats, Anna, Lee, Han Ah., Azam, Zahid, Kumar, Pramod, Hayes, Peter C., Sauerbruch, Tilman, and Chen, Wen‐Chi

Subjects
CIRRHOSIS of the liver, SURVIVAL analysis (Biometry), HEMORRHAGE, PREVENTIVE medicine, OVERALL survival, TREATMENT effectiveness
Abstract

Background & Aims: Non‐selective β‐blockers (NSBBs) and endoscopic variceal‐ligation (EVL) have similar efficacy preventing first variceal bleeding. Compensated and decompensated cirrhosis are markedly different stages, which may impact treatment outcomes. We aimed to assess the efficacy of NSBBs vs EVL on survival in patients with high‐risk varices without previous bleeding, stratifying risk according to compensated/decompensated stage of cirrhosis. Methods: By systematic review, we identified RCTs comparing NSBBs vs EVL, in monotherapy or combined, for primary bleeding prevention. We performed a competing‐risk, time‐to‐event meta‐analysis, using individual patient data (IPD) obtained from principal investigators of RCTs. Analyses were stratified according to previous decompensation of cirrhosis. Results: Of 25 RCTs eligible, 14 failed to provide IPD and 11 were included, comprising 1400 patients (656 compensated, 744 decompensated), treated with NSBBs (N = 625), EVL (N = 546) or NSBB+EVL (N = 229). Baseline characteristics were similar between groups. Overall, mortality risk was similar with EVL vs. NSBBs (subdistribution hazard‐ratio (sHR) = 1.05, 95% CI = 0.75–1.49) and with EVL + NSBBs vs either monotherapy, with low heterogeneity (I2 = 28.7%). In compensated patients, mortality risk was higher with EVL vs NSBBs (sHR = 1.76, 95% CI = 1.11–2.77) and not significantly lower with NSBBs+EVL vs NSBBs, without heterogeneity (I2 = 0%). In decompensated patients, mortality risk was similar with EVL vs. NSBBs and with NSBBs+EVL vs. either monotherapy. Conclusions: In patients with compensated cirrhosis and high‐risk varices on primary prophylaxis, NSBBs significantly improved survival vs EVL, with no additional benefit noted adding EVL to NSBBs. In decompensated patients, survival was similar with both therapies. The study suggests that NSBBs are preferable when advising preventive therapy in compensated patients. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Stratified efficacy of first -line therapy to prevent first variceal bleeding according to previous decompensation of cirrhosis. A competing-risk meta-analyses of individual participant data

Author

Villanueva, Càndid, primary, Sapena, Víctor, additional, Lo, Gin-Ho, additional, Seo, Yeon Seok, additional, Shah, Hasnain A., additional, Singh, Virendra, additional, Tripathi, Dhiraj, additional, Schepke, Michael, additional, Gheorghe, Cristian, additional, Bonilha, Danielle Q, additional, Jutabha, Rome, additional, Rodrigues, Susana G., additional, Alvarado-Tapias, Edilmar, additional, Brujats, Anna, additional, Hayes, Peter, additional, Sauerbruch, Tilman, additional, Chen, Wen-Chi, additional, Iacob, Speranta, additional, Libera, Ermelindo D, additional, Jensen, Dennis M, additional, Kumar, Pramod, additional, Ah, Lee Han, additional, Wang, Huay-Min, additional, Torres, Ferran, additional, Azam, Zahid, additional, and Bosch, Jaime, additional

Published
2022
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26. Non-invasive tools for compensated advanced chronic liver disease and portal hypertension after Baveno VII – an update.

Author

Segna, Daniel, Mendoza, Yuly P., Lange, Naomi F., Rodrigues, Susana G., and Berzigotti, Annalisa

Abstract

Non-invasive tests (NITs) and liver stiffness measurement (LSM) in particular, have entered clinical practice over 20 years ago as point-of-care tests to diagnose liver fibrosis in patients with compensated chronic liver disease. Since then, NITs use has evolved thanks to a large number of studies in all major etiologies of liver disease, and they have become important tools to stratify the risk of portal hypertension and liver-related events. The Baveno VII consensus workshop provided several novel recommendations regarding the use of well-established and novel NITs in the specific setting of portal hypertension screening, diagnosis and follow-up. The Baveno VII expert panels paid special attention to summarizing the existing data into simple clinical rules able to guide clinicians in their practice. The "rule of five" for LSM is a tool to stratify the risk of liver-related events, and LSM alone or in combination with platelet count, can be used now to rule-in and rule-out compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension, as well as to rule-out high-risk varices. Use of NITs in obese subjects with non-alcoholic fatty liver disease (NAFLD) and patients with viral hepatitis C that has been successfully treated, require specific knowledge. This review will update the reader on these aspects. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Inflammatory activity affects the accuracy of liver stiffness measurement by transient elastography but not by two‐dimensional shear wave elastography in non‐alcoholic fatty liver disease

Author

Mendoza, Yuly P., primary, Rodrigues, Susana G., additional, Delgado, Maria G., additional, Murgia, Giuseppe, additional, Lange, Naomi F., additional, Schropp, Jonas, additional, Montani, Matteo, additional, Dufour, Jean‐François, additional, and Berzigotti, Annalisa, additional

Published
2021
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31. Noninvasive Diagnosis of Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease

Author

Pons, Monica, primary, Augustin, Salvador, additional, Scheiner, Bernhard, additional, Guillaume, Maeva, additional, Rosselli, Matteo, additional, Rodrigues, Susana G., additional, Stefanescu, Horia, additional, Ma, Mang M., additional, Mandorfer, Mattias, additional, Mergeay-Fabre, Mayka, additional, Procopet, Bogdan, additional, Schwabl, Philipp, additional, Ferlitsch, Arnulf, additional, Semmler, Georg, additional, Berzigotti, Annalisa, additional, Tsochatzis, Emmanuel, additional, Bureau, Christophe, additional, Reiberger, Thomas, additional, Bosch, Jaime, additional, Abraldes, Juan G., additional, and Genescà, Joan, additional

Published
2020
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33. Early-tips should be performed in high-risk cirrhotic patients despite the presence of hepatic encephalopathy at admission

Author

Rudler, Marika, primary, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Jonel, Trebicka, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Alonso, José Castellote, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Cañete, Nuria, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romanno, additional, Dell’Era, Alessandra, additional, Abraldes, Juan G., additional, Barcelo, Rafael, additional, Senzolo, Marco, additional, Gomez, Manuel Romero, additional, Zipprich, Alexander, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Torres, Ferran, additional, Nevens, Frederik, additional, Calleja Panero, José Luis, additional, Casanovas, Georgina, additional, Jansen, Christian, additional, Albillos, Agustin, additional, Maria, Guardascione, additional, Alvarado, Edilmar, additional, Casas, Meritxell, additional, Robic, Marie-Angèle, additional, Catalina, María-Vega, additional, Sosa, Irene Conejo, additional, Maxime, Mallet, additional, Simona, Tripon, additional, Bosch, Jaime, additional, Garcia Pagan, Juan Carlos, additional, and Thabut, Dominique, additional

Published
2020
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35. Pre-emptive (early) transjugular intrahepatic porto-systemic shunt in the treatment of high-risk acute variceal bleeding. An individual patient data meta-analysis

Author

Garcia Pagan, Juan Carlos, primary, Nicoara-Farcau, Oana, additional, Angrisani, Debora, additional, Monescillo, Alberto, additional, Han, Guohong, additional, Torres, Ferran, additional, Bosch, Jaime, additional, Casanovas, Georgina, additional, Lv, Yong, additional, Fan, Daiming, additional, Bureau, Christophe, additional, Nevens, Frederik, additional, Caca, Karel, additional, Luca, Angelo, additional, Zipprich, Alexander, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez, Luis, additional, Trebika, Jonel, additional, Genesca, Joan, additional, Palazon, Jose María, additional, Alonso, José Castellote, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Noronha Ferreira, Carlos Alberto Costa, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Sassatelli, Romano, additional, Dell’Era, Alessandra, additional, Senzolo, Marco, additional, Gomez, Manuel Romero, additional, Guerra, Manuel Hernández, additional, Casas, Meritxell, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Calleja Panero, José Luis, additional, Cañete, Nuria, additional, Masnou, Helena, additional, Mössner, Joachim, additional, and Hernandez-Gea, Virginia, additional

Published
2020
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37. Inflammatory activity affects the accuracy of liver stiffness measurement by transient elastography but not by two‐dimensional shear wave elastography in non‐alcoholic fatty liver disease.

Author

Mendoza, Yuly P., Rodrigues, Susana G., Delgado, Maria G., Murgia, Giuseppe, Lange, Naomi F., Schropp, Jonas, Montani, Matteo, Dufour, Jean‐François, and Berzigotti, Annalisa

Subjects
*FATTY liver, *NON-alcoholic fatty liver disease, *SHEAR waves, *ELASTOGRAPHY, *BODY mass index, *LIVER
Abstract

Background: In patients with non‐alcoholic fatty liver disease (NAFLD), the impact of the severity of steatosis and inflammatory activity on the accuracy of liver stiffness measurement (LSM) by transient elastography (TE) and by two‐dimensional shear wave elastography (2D‐SWE) in staging liver fibrosis is still debated and scarce. We aimed to focus on this aspect. Methods: We prospectively studied 104 patients requiring biopsy for the assessment of NAFLD. We used ordinary least squares regression to test for differences in the association between fibrosis and LSM by TE and 2D‐SWE when other factors (steatosis and inflammatory activity) are considered. Results: Among 104 patients, 102 had reliable LSM by TE, and 88 had valid LSM by 2D‐SWE. The association between fibrosis based on histology and LSM was significantly stronger when 2D‐SWE assessed LSM compared to TE (Spearman's correlation coefficient of.71; P <.001 vs.51, P <.001; Z = 2.21, P =.027). Inflammatory activity was an independent predictor of LSM by TE but not of LSM by 2D‐SWE. After controlling for fibrosis, age, sex and body mass index, the inflammatory activity and the interaction between inflammatory activity and fibrosis independently explained 11% and 13% of variance in LSM by TE respectively. Steatosis did not affect the association of fibrosis and LSM by either method. Conclusion: Inflammatory activity on histology significantly affects LSM by TE, but not LSM by 2D‐SWE in NAFLD. LSM by 2D‐SWE reflects liver fibrosis more accurately than LSM by TE. Furthermore, the severity of steatosis on histology did not influence the association of LSM and fibrosis by either elastography method. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Controlled attenuation parameter reflects steatosis in compensated advanced chronic liver disease

Author

Piccinni, Rosangela, primary, Rodrigues, Susana G., additional, Montani, Matteo, additional, Murgia, Giuseppe, additional, Delgado, Maria G., additional, Casu, Stefania, additional, Stirnimann, Guido, additional, Semmo, Nasser, additional, De Gottardi, Andrea, additional, Dufour, Jean‐François, additional, and Berzigotti, Annalisa, additional

Published
2019
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39. Adipopenia correlates with higher portal pressure in patients with cirrhosis

Author

Rodrigues, Susana G, Brabandt, Ben, Stirnimann, Guido, Maurer, Martin, and Berzigotti, Annalisa

Subjects
610 Medicine & health
Abstract

BACKGROUND & AIMS In cirrhosis, hepatic venous pressure gradient (HVPG) and imaging body composition assessment can influence prognosis. We assessed whether adipose and skeletal muscle tissue reflect the severity of portal hypertension (PH), and whether they improve non-invasive prediction of decompensation and death. METHODS We included 84 cirrhosis patients with HVPG and computed tomography (CT) within 12 weeks of HVPG at a single centre. L3 vertebra CT images were used for body composition indexes (cm /m ): total adipose tissue index (TATI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), intramuscular adipose tissue index (IMATI), skeletal muscle index (SMI) and psoas muscle index (PMI). Correlations were calculated between indexes, HVPG and standard non-invasive tests for PH. 12-month decompensation and death predictors were determined. RESULTS Male 61%; BMI 28±5 kg/m ; alcoholic liver disease in 51%, non-alcoholic steatohepatitis in 24%; HVPG 14±6 mmHg; 45% compensated. Median follow-up was 11 (4-17) months. HVPG correlated with SATI (r=-0.282,p=0.01), TATI (r=-0.220,p=0.045) and SATI/VATI index (r =-0.240,p=0.03). In compensated patients, lower VATI (HR 0.94 (0.90-0.99), p=0.01) was associated with 12-month decompensation. Combining TATI and liver stiffnessxspleen size over-platelet count risk score (LSPS) added discriminative capacity for 12-month decompensation (AUROC 0.91 vs. 0.87). IMATI was independently associated with mortality in decompensated patients. MELD-Na combined with IMATI discriminated excellently for mortality (AUROC 0.94; p

Published
2019
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40. Noninvasive Diagnosis of Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease.

Author

Pons, Monica, Augustin, Salvador, Scheiner, Bernhard, Guillaume, Maeva, Rosselli, Matteo, Rodrigues, Susana G., Stefanescu, Horia, Mang M. Ma, Mandorfer, Mattias, Mergeay-Fabre, Mayka, Procopet, Bogdan, Schwabl, Philipp, Ferlitsch, Arnulf, Semmler, Georg, Berzigotti, Annalisa, Tsochatzis, Emmanuel, Bureau, Christophe, Reiberger, Thomas, Bosch, Jaime, and Abraldes, Juan G.

Published
2021
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43. SAT-079-Respiratory infection in patients with cirrhosis and acute variceal bleeding on antibiotic prophylaxis: A multicenter observational study of 2138 patients

Author

Martinez, Javier, primary, luis, Tellez, additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Genesca, Joan, additional, christophe, Bureau, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Castellote, José, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Mundi, Jose Luis, additional, Granbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romanno, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-gómez, Manolo, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Panero, José Luis Calleja, additional, Jansen, Christian, additional, Robic, Marie Angele, additional, Conejo, Irene, additional, Catalina, Maria-Vega, additional, Rudler, Marika, additional, Bañares, Rafael, additional, Alvarado, Edilmar, additional, Trebicka, Jonel, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Torres, Ferran, additional, Bosch, Jaime, additional, Carlos, Garcia Pagan Juan, additional, and Albillos, Agustin, additional

Published
2019
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44. PS-023-Factors predicting survival in patients with high-risk acute variceal bleeding treated with pre-emptive (Early)-TIPS

Author

Angrisani, Debora, primary, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Caca, Karel, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Guardascione, Maria Anna, additional, Villanueva, Candid, additional, Alvarado, Edilmar, additional, Thabut, Dominique, additional, Rudler, Marika, additional, Ibañez, Luis, additional, Bañares, Rafael, additional, Catalina, María-Vega, additional, Turon, Fanny, additional, Albillos, Agustin, additional, Martinez, Javier, additional, Genesca, Joan, additional, Sosa, Irene Conejo, additional, Baiges, Anna, additional, christophe, Bureau, additional, Vinel, Jean Pierre, additional, Robic, Marie-Angele, additional, Sauerbruch, Tilman, additional, TREBICKA, Jonel, additional, Appenrodt, Beate, additional, Jansen, Christian, additional, Llop, Elba, additional, Calleja Panero, José Luis, additional, Laleman, Wim, additional, Nevens, Frederik, additional, Palazon, Jose María, additional, Castellote, José, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Cañete, Nuria, additional, Tantau, Marcel, additional, Magaz, Marta, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Ferrusquia, José, additional, Mössner, Joachim, additional, Sassatelli, Romanno, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, ABRALDES, Juan G, additional, Gomez, Manuel Romero, additional, Zipprich, Alexander, additional, Luca, Angelo, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Casanovas, Georgina, additional, Torres, Ferran, additional, Krag, Aleksander, additional, Bosch, Jaime, additional, Monescillo, Alberto, additional, and GARCIA-PAGAN, Juan-Carlos, additional

Published
2019
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46. Controlled attenuation parameter reflects steatosis in compensated advanced chronic liver disease.

Author

Piccinni, Rosangela, Rodrigues, Susana G., Montani, Matteo, Murgia, Giuseppe, Delgado, Maria G., Casu, Stefania, Stirnimann, Guido, Semmo, Nasser, De Gottardi, Andrea, Dufour, Jean‐François, and Berzigotti, Annalisa

Subjects
*LIVER diseases, *FATTY liver, *CHRONIC diseases, *BODY mass index, *LIVER biopsy
Abstract

Background & Aims: Controlled attenuation parameter (CAP) for steatosis assessment has not been validated in compensated advanced chronic liver disease compensated advanced chronic liver disease (cACLD). We primarily aimed at assessing the accuracy of CAP for the diagnosis and quantification of steatosis in cACLD. Secondary aim: to assess the validity of non‐invasive criteria for cACLD according to liver stiffness measurement (LSM). Methods: This is a single‐centre retrospective study including patients with cACLD defined as LSM ≥10 kPa, CAP measurement and liver biopsy (reference standard for steatosis and fibrosis) observed in 06/2015‐06/2017. Steatosis was graded as S0 (<5%), S1 (5%‐32%), S2 (33%‐66%) and S3 (>66%). The diagnostic performance of CAP for any grade of steatosis and for high‐grade steatosis (≥S2) was studied. Results: Among 461 consecutive patients, 111 with LSM‐based diagnosis of cACLD were included (63% male, median age 55 years, median body mass index 28.1 Kg/m2, aetiology: 32% non‐alcoholic fatty liver disease/non‐alcoholic steatohepatitis, 32% alcohol or viral + metabolic syndrome, 15% viral, 6% autoimmune, 4% alcohol, 11% others). Median LSM and CAP were 16.1 kPa and 277 dB/m respectively. On liver biopsy, steatosis was found in 88/111 patients (79%); 44 patients (43 with metabolic syndrome) had high‐grade steatosis. CAP was accurate in identifying any grade of steatosis (area under the receiving operating characteristic curves 0.847; 95% CI 0.767‐0.926, P <.0001), and ≥S2 steatosis (0.860; 95% CI 0.788‐0.932, P <.0001). CAP performed similarly in patients with CAP‐ interquartile range (IQR) ≥ or <40 dB/m. Conclusions: Steatosis is frequent in patients with cACLD and metabolic syndrome. CAP diagnostic accuracy for any steatosis and high‐grade steatosis is good in this population. A CAP‐IQR ≥40 dB/m does not impair CAP diagnostic accuracy in cACLD. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Systematic review with meta‐analysis: portal vein recanalisation and transjugular intrahepatic portosystemic shunt for portal vein thrombosis.

Author

Rodrigues, Susana G., Sixt, Sebastian, Abraldes, Juan G., De Gottardi, Andrea, Klinger, Christoph, Bosch, Jaime, Baumgartner, Iris, and Berzigotti, Annalisa

Subjects
*THROMBOSIS surgery, *SURGICAL anastomosis, *SYSTEMATIC reviews, *CATHETER-related thrombosis, PORTAL vein diseases
Abstract

Summary: Background: Transjugular intrahepatic portosystemic shunt has been increasingly used in patients with portal vein thrombosis to obtain patency, but evidenced‐based decisions are challenging. Aim: To evaluate published data on efficacy and safety of endovascular therapy in portal vein thrombosis. Methods: Systematic search of PubMed, ISI, Scopus, and Embase for studies (in English, until October 2017) reporting feasibility, safety, 12‐month portal vein recanalisation, transjugular intrahepatic portosystemic shunt patency, and survival in patients with benign portal vein thrombosis undergoing endovascular treatment. An independent extraction of articles using predefined data fields and quality indicators was used; pooled analyses based on random‐effects models; heterogeneity assessment by Cochran's Q, I2 statistic, subgroup analyses, and meta‐regression. Results: Thirteen studies including 399 patients (92% cirrhosis; portal vein thrombosis: complete 46%, chronic 87%, cavernous transformation 17%, superior mesenteric vein involvement 55%) were included. Transjugular intrahepatic portosystemic shunt was technically feasible in 95% (95% CI: 89%‐98%) with heterogeneity (I2 = 57%, P < 0.001) explained by cavernous transformation. Major complications occurred in 10% (95% CI: 6.0%‐18.0%; I2 = 52%, P = 0.55). Additional catheter‐directed thrombolysis was associated with more complications compared to transjugular intrahepatic portosystemic shunt alone or plus thrombectomy (17.6% vs 3.3%). Twelve‐month portal vein recanalisation was 79% (95% CI: 67%‐88%; I2 = 78%, P < 0.01). Shunt patency at 12 months was 84% (95% CI: 76%‐90%; I2 = 62%, P < 0.01). Overall 12‐month survival rate was 89%, with no heterogeneity. Conclusions: Transjugular intrahepatic portosystemic shunt for portal vein thrombosis recanalisation was highly feasible, effective, and safe. Cavernous transformation was the main determinant of technical failure. Additional catheter‐directed thrombolysis was associated with higher risk of severe complications. [ABSTRACT FROM AUTHOR]

Published
2019
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