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15 results on '"Rodrigues, Vanessa Fernandes"'

2. Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile

Author

Manso, Gabriel Martins da Costa, Elias-Oliveira, Jefferson, Guimarães, Jhefferson Barbosa, Pereira, Ítalo Sousa, Rodrigues, Vanessa Fernandes, Burger, Beatriz, Fantacini, Daianne Maciely Carvalho, de Souza, Lucas Eduardo Botelho, Rodrigues, Hosana Gomes, Bonato, Vânia Luiza Deperon, Silva, João Santana, Ramos, Simone Gusmão, Tostes, Rita Cassia, Manfiolli, Adriana Oliveira, Caliari-Oliveira, Carolina, and Carlos, Daniela

Published
2023
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4. Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model.

Author

Guimarães, Jhefferson Barbosa, Rodrigues, Vanessa Fernandes, Pereira, Ítalo Sousa, Manso, Gabriel Martins da Costa, Elias-Oliveira, Jefferson, Leite, Jefferson Antônio, Waldetario, Mariana Camila Gonçalves Miranda, Oliveira, Sarah de, Gomes, Arilson Bernardo dos Santos Pereira, Faria, Ana Maria Caetano, Ramos, Simone Gusmão, Bonato, Vânia L D, Silva, João Santana, Vinolo, Marco Aurélio Ramirez, Sampaio, Ulliana Marques, Clerici, Maria Teresa Pedrosa Silva, and Carlos, Daniela

Subjects
REGULATORY T cells, TYPE 1 diabetes, GUT microbiome, ISLANDS of Langerhans, INULIN
Abstract

Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affects T1D remains uncertain. Using a streptozotocin-induced (STZ) mouse model, we studied INU's protective effects. Remarkably, STZ + INU mice resisted T1D, with none developing the disease. They had lower blood glucose, reduced pancreatic inflammation, and normalized serum insulin compared with STZ + SD mice. STZ + INU mice also had enhanced mucus production, abundant Bifidobacterium , Clostridium cluster IV, Akkermansia muciniphila , and increased fecal butyrate. In cecal lymph nodes, we observed fewer CD4+Foxp3+ regulatory T cells expressing CCR4 and more Foxp3+CCR4+ cells in pancreatic islets, with higher CCL17 expression. This phenotype was absent in CCR4-deficient mice on INU. INU supplementation effectively protects against experimental T1D by recruiting CCR4+ regulatory T cells via CCL17 into the pancreas and altering the butyrate-producing microbiota. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model

Author

Guimarães, Jhefferson Barbosa, primary, Rodrigues, Vanessa Fernandes, additional, Pereira, Ítalo Sousa, additional, Manso, Gabriel Martins da Costa, additional, Elias-Oliveira, Jefferson, additional, Leite, Jefferson Antônio, additional, Waldetario, Mariana Camila Gonçalves Miranda, additional, de Oliveira, Sarah, additional, Gomes, Arilson Bernardo dos Santos Pereira, additional, Faria, Ana Maria Caetano, additional, Ramos, Simone Gusmão, additional, Bonato, Vânia L D, additional, Silva, João Santana, additional, Vinolo, Marco Aurélio Ramirez, additional, Sampaio, Ulliana Marques, additional, Clerici, Maria Teresa Pedrosa Silva, additional, and Carlos, Daniela, additional

Published
2023
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6. The Th2 Response and Alternative Activation of Macrophages Triggered by Strongyloides venezuelensis Is Linked to Increased Morbidity and Mortality Due to Cryptococcosis in Mice

Author

Gouveia-Eufrasio, Ludmila, primary, de Freitas, Gustavo José Cota, additional, Costa, Marliete Carvalho, additional, Peres-Emidio, Eluzia Castro, additional, Carmo, Paulo Henrique Fonseca, additional, Rodrigues, João Gustavo Mendes, additional, de Rezende, Michelle Carvalho, additional, Rodrigues, Vanessa Fernandes, additional, de Brito, Camila Bernardo, additional, Miranda, Guilherme Silva, additional, de Lima, Pâmela Aparecida, additional, da Silva, Lívia Mara Vitorino, additional, Oliveira, Jefferson Bruno Soares, additional, da Paixão, Tatiane Alves, additional, da Glória de Souza, Daniele, additional, Fagundes, Caio Tavares, additional, Peres, Nalu Teixeira de Aguiar, additional, Negrão-Correa, Deborah Aparecida, additional, and Santos, Daniel Assis, additional

Published
2023
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8. Experimental infection withSchistosoma mansoniisolated from the wild rodentHolochilus sciureusshows a low parasite burden but induces high schistosomiasis severity in BALB/c mice

Author

Miranda, Guilherme Silva, primary, Rodrigues, João Gustavo Mendes, additional, de Rezende, Michelle Carvalho, additional, Resende, Samira Diniz, additional, Camelo, Genil Mororó Araújo, additional, de Oliveira Silva, Jeferson Kelvin Alves, additional, Maggi, Laura, additional, Rodrigues, Vanessa Fernandes, additional, de Oliveira, Vinícius Gustavo, additional, and Negrão-Corrêa, Deborah Aparecida, additional

Published
2022
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11. Experimental infection with Schistosoma mansoni isolated from the wild rodent Holochilus sciureus shows a low parasite burden but induces high schistosomiasis severity in BALB/c mice.

Author

Miranda, Guilherme Silva, Mendes Rodrigues, João Gustavo, de Rezende, Michelle Carvalho, Resende, Samira Diniz, Araújo Camelo, Genil Mororó, de Oliveira Silva, Jeferson Kelvin Alves, Maggi, Laura, Rodrigues, Vanessa Fernandes, de Oliveira, Vinícius Gustavo, and Negrão-Corrêa, Deborah Aparecida

Abstract

Wild mammals, especially rodents, can participate in the life cycle of Schistosoma mansoni; however, the impact of these parasite strains on the severity of schistosomiasis remains unclear. The aim of this study was to comparatively evaluate the parasitological and immunopathological alterations induced by an S. mansoni strain isolated from the wild rodent Holochilus sciureus (HS strain) and a parasite strain isolated from a human (LE strain) in experimentally infected mice. Male BALB/c mice were subcutaneously infected with 50 cercariae/ mouse of either the HS or the LE strain and were evaluated for 12 weeks. In the experimental groups, the parasite burden was estimated by worm and egg (feces and tissues) count, and immunopathological alterations were evaluated in the liver and intestines. Compared to experimental infection with the LE parasite strain, HS-infected mice showed reduced number of parasite worms but higher fecundity rate, significant reduction in IL-5, IL-10 and IL-13 concentrations, lower EPO-activity in liver homogenate and higher concentrations of TNF-α, IFN-γ, IL-12 and IL-17 in the small intestine homogenate. Moreover, HS infection resulted in higher concentrations of NO end-products in both the liver and intestine, suggesting a predominance of the Th1/Th17 immune response. HS-infected mice also showed higher plasma transaminase levels, formed larger granulomas, and had a higher mortality rate in comparison with LE-infected mice. Data indicate that BALB/c mice infected with the HS strain of S. mansoni showed reduced susceptibility to the parasite but stronger tissue inflammation and high disease severity. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Acute infection with Strongyloides venezuelensis increases intestine production IL-10, reduces Th1/Th2/Th17 induction in colon and attenuates Dextran Sulfate Sodium-induced colitis in BALB/c mice

Author

Rodrigues, Vanessa Fernandes, primary, Bahia, Márcia Paulliny Soares, additional, Cândido, Núbia Rangel, additional, Moreira, João Marcelo Peixoto, additional, Oliveira, Vinicius Gustavo, additional, Araújo, Emília Souza, additional, Rodrigues Oliveira, Jailza Lima, additional, Rezende, Michelle de Carvalho, additional, Correa, Ary, additional, and Negrão-Corrêa, Deborah, additional

Published
2018
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15. Improvement of the liver pathology by the aqueous extract and the n-butanol fraction of Sida pilosa Retz in Schistosoma mansoni-infected mice.

Author

Jatsa, Hermine Boukeng, Russo, Remo Castro, Pereira, Cintia Aparecida de Jesus, Aguilar, Edenil Costa, Garcia, Cristiana Couto, Araújo, Emília Souza, Oliveira, Jailza Lima Rodrigues, Rodrigues, Vanessa Fernandes, de Oliveira, Vinícius Gustavo, Alvarez-Leite, Jacqueline Isaura, Braga, Fernão Castro, Louis-Albert Tchuem Tchuente, null, Kamtchouing, Pierre, Negrão-Corrêa, Deborah Aparecida, and Teixeira, Mauro Martins

Subjects
*BIOLOGICAL models, *EOSINOPHILS, *LIVER diseases, *MICE, *SUPEROXIDE dismutase, *MALONDIALDEHYDE, *PLANT extracts
Abstract

Ethnopharmacological relevance Sida pilosa Retz (Malvaceae) is a plant used in Africa for the treatment of intestinal helminthiasis, lower abdominal pains and dysmenorrhea. Aim of the study In order to determine the potential use of S. pilosa in the treatment of schistosomiasis mansoni, we evaluated the schistosomicidal, antioxidant and anti-fibrotic properties of the aqueous extract and the n -butanol fraction of its aerial parts. Material and methods S. pilosa aqueous extract (SpAE) at 100, 200 and 400 mg/kg and n -butanol fraction (SpBF) at 50, 100 and 200 mg/kg were administered per os to Schistosoma mansoni -infected mice for 4 weeks. Praziquantel (100 mg/kg×5 days) was used as reference drug. After sacrifice, worm burden and egg count, transaminases and proteins levels were evaluated. Malondialdehyde (MDA), lipid hydroperoxydes (LOOH), catalase (CAT), superoxide dismutase (SOD), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) were also measured. The anti-fibrotic effect of the plant was evaluated by the determination of hydroxyproline and γ-interferon (IFN-γ). Results The treatment of S. mansoni -infected mice by SpAE or SpBF resulted in a moderate reduction of worm burden and egg load in the liver and intestine. Both SpAE and SpBF significantly reversed the increasing liver proteins, MDA, LOOH and CAT levels induced by the infection. Moreover, SOD activity was improved by SpAE and SpBF. Schistosomiasis mansoni considerably increased the EPO ( p <0.001) and MPO activities ( p <0.001). SpAE treatment significantly reduced EPO and MPO activities at all doses. SpBF failed to reduce the increasing MPO and decreased EPO only at the highest dose. S. mansoni -infection induced an increase in hydroxyproline content ( p <0.001) and a decrease in IFN-γ level ( p <0.001). Both SpAE and SpBF significantly reduced hepatic hydroxyproline content, while only SpAE ( p <0.05) improved IFN-γ level. Conclusion These results suggest that the liver pathology in schistosomiasis mansoni is improved by S. pilosa aqueous extract, which disclosed a moderate schistosomicidal, but strong antioxidant and anti-fibrotic activities. The n -butanol fraction was however less active than the aqueous extract. [ABSTRACT FROM AUTHOR]

Published
2016
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