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The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0 ± 0.2 vs 9.5 ± 0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis = 9.3 ± 0.1,9.1 ± 0.1 and 9.6 ± 0.2 for introduction at ≤ 6 months, between 7 and 11 months and [greater than or equal to] 12 months, respectively; P = 0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status. European Journal of Clinical Nutrition (2014) 68, 1258-1260; doi:10.1038/ejcn.2014.159; published online 13 August 2014, INTRODUCTION Type 1 diabetes mellitus is one of the leading chronic diseases of childhood, affecting 1.54 youth per 1,000 in the United States, according to the SEARCH for Diabetes in [...]

OBJECTIVE:: This study was conducted to examine the influence of insulin resistance on weight change in postmenopausal women of various ethnic groups. SUBJECTS:: Data were obtained from 3389 women (60% White, 20% Black, 12% Hispanic, and 8% Asian/Pacific Islander), ages 50-79, enrolled in either the Women's Health Initiative Clinical trial or Observational Study, whose blood samples were selected randomly from the full cohort of 161?809 women for analyses. MEASUREMENTS:: Glucose, insulin, and lipids were measured on fasting serum samples drawn at baseline and after 3?y of follow-up. Weight, height, waist circumference, and blood pressure were measured. Physical activity and energy intake were assessed via questionnaire. Insulin resistance was estimated using the HOMA (homeostasis model) calculation. RESULTS:: Average age was 62?y, average BMI (body mass index) was 27.4?kg/m2, and average weight change was a gain of 0.4?kg in 3?y. In a multivariate analysis, insulin resistance and insulin concentrations were independent predictors of increases in weight in White women (P=0.002 and 0.004, respectively) and in the combined group (P=0.027 and 0.039). For the whole group, after adjustment for other covariates, those in the highest quartile of insulin resistance gained 0.4?kg in 3?y, whereas those in the lowest quartile lost 0.06?kg. Similar trends were found for insulin resistance and weight gain in Hispanic and Asian/Pacific Islander women, but they did not reach statistical significance. In Black women, no relation was seen between either insulin or insulin resistance and weight change. A significant interaction between obesity and insulin resistance was observed (P=0.002 for White women and 0.032 for the whole group), so that there is weight gain with increasing insulin resistance in the leaner women, but weight loss with increasing insulin resistance in the most obese. CONCLUSION:: Insulin resistance appears to be a predictor of weight gain in postmenopausal women, except for the most obese women. The effect is more pronounced in women who have a lower BMI, and the effect was not seen in the Black women who as a group had a higher BMI.International Journal of Obesity (2004) 28, 1039-1047. doi:10.1038/sj.ijo.0802645 [ABSTRACT FROM AUTHOR]

Investigates the relationship between fasting glucose and 2h glucose with percentage of Hawaiian ancestry and ethnic admixture. Cross-sectional epidemiological study of type 2 diabetes and heart disease risk factor prevalence among native Hawaiians; Relationship between ancestry and glucose tolerance in earlier observations of the population.

Despite similar traditional risk factors, morbidity and mortality rates from coronary heart disease in western and non-western cohorts remain substantially different. Careful study of such cohorts may help identify novel risk factors for CHD, and contribute to the formulation of new preventive strategies [ABSTRACT FROM AUTHOR]