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9 results on '"Rodriguez Granillo, G. A."'

4. Methodological considerations and approach to cross‐technique comparisons using in vivo coronary plaque characterization based on intravascular ultrasound radiofrequency data analysis: insights from the Integrated Biomarker and Imaging Study (IBIS)

Author

Rodriguez‐Granillo, G. A., primary, Aoki, J., additional, Ong, A. T. L., additional, Valgimigli, M., additional, van Mieghem, C. A. G., additional, Regar, E., additional, McFadden, E., additional, de Feyter, P., additional, and Serruys, P. W., additional

Published
2005
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6. One year clinical followup of paclitaxel eluting stents for acute myocardial infarction compared with sirolimus eluting stents.

Author

Hofma, S. H., Ong, A. T. L., Aoki, J., van Mieghem, C. A. G., Rodriguez Granillo, G. A., Valgimigli, M., Regar, E., de Jaegere, P. P. T., McFadden, E. P., Sianos, G., van der Giessen, W. J., de Feyter, P. J., van Domburg, R. T., and Serruys, P. W.

Subjects
PACLITAXEL, ALKALOIDS, RAPAMYCIN, SURGICAL stents, MYOCARDIAL infarction, HEART diseases, ANTINEOPLASTIC agents, BLOOD coagulation
Abstract

Objective: To compare clinical outcome of paclitaxel eluting stents (PES) versus sirolimus eluting stents (SES) for the treatment of acute ST elevation myocardial infarction. Design and patients: The first 136 consecutive patients treated exclusively with PES in the selling of primary percutaneous coronary intervention for acute myocardial infarction in this single centre registry were prospectively clinically assessed at 30 days and one year. They were compared with 186 consecutive patients treated exclusively with SES in the preceding period. Setting: Academic tertiary referral centre. Results: At 30 days, the rate of all cause mortality and reinfarction was similar between groups (6.5% v 6.6% for SES and PES, respectively, p = 1.0). A significant difference in target vessel revascularisation (TVR) was seen in favour of SES (1.1% v 5.1% for PES, p = 0.04). This was driven by stent thrombosis (n = 4), especially in the bifurcation stenting (n = 2). At one year, no significant differences were seen between groups, with no late thrombosis and 1.5% in-stent restenosis (needing TVR) in PES versus no reinterventions in SES (p = 0.2). One year survival free of major adverse cardiac events (MACE) was 90.2% for SES and 85% for PES (p = 0.16). Conclusions: No significant differences were seen in MACE-free survival at one year between SES and PES for the treatment of acute myocardial infarction with very low rates of reintervention for restenosis. Bifurcation stenting in acute myocardial infarction should, if possible, be avoided because of the increased risk of stent thrombosis. [ABSTRACT FROM AUTHOR]

Published
2005
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7. Methodological considerations and approach to cross-technique comparisons using in vivo coronary plaque characterization based on intravascular ultrasound radiofrequency data analysis: insights from the Integrated Biomarker and Imaging Study (IBIS)

Author

Rodriguez-Granillo, G. A., Aoki, J., Ong, A. T. L., Valgimigli, M., van Mieghem, C. A. G., Regar, E., McFadden, E., de Feyter, P., and Serruys, P. W.

Abstract

Grey scale intravascular ultrasound (IVUS) is a valuable clinical tool to assess the extent and severity of coronary atheroma. However, it cannot reliably identify plaques with a high-risk of future clinical events. Serial IVUS studies to assess the progression and/or regression of atherosclerotic plaques demonstrated only modest effects, of pharmacological intervention on plaque burden, even when clinical efficacy is documented. Spectral analysis of radiofrequency ultrasound data (IVUS-virtual histologyTM (IVUS-VH), Volcano Therapeutics, Rancho Cordova, CA) has the potential to characterize accurately plaque composition. The Integrated Biomarker and Imaging Study (IBIS) evaluated both invasive and non-invasive imaging techniques along with the assessment of novel biomarkers to characterize sub-clinical atherosclerosis. IVUS-VH was not included at the start of the IBIS protocol. The purpose of this paper is to describe the methodology we used to obtain and analyse IVUS-VH images and the approach to cross-correlations with the other techniques.

Published
2005
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9. Parameters for coronary plaque vulnerability assessed with multidetector computed tomography and intracoronary ultrasound correlation

Author

Eleni C. Vourvouri, Francesca Pugliese, Nico R. Mollet, Ludovico La Grutta, Willem B. Meijboom, Gaston A. Rodriguez-Granillo, Filippo Cademartiri, Jurgen Ligthart, Pim J. de Feyter, Gabriel P. Krestin, Pugliese, F, Meijboom, WB, Ligthart, J, La Grutta, L, Vourvouri, EC, Rodriguez-Granillo, G, Mollet, NR, Krestin, GP, de Feyter, PJ, Cademartiri, F, Radiology & Nuclear Medicine, and Cardiology

Subjects
medicine.medical_specialty, Acute coronary syndrome, Vulnerability, Coronary Angiography, medicine.disease_cause, Risk Assessment, Severity of Illness Index, Lesion, Correlation, Predictive Value of Tests, Risk Factors, Internal medicine, Intravascular ultrasound, Humans, Medicine, Acute Coronary Syndrome, Ultrasonography, Interventional, Rupture, medicine.diagnostic_test, business.industry, Coronary Stenosis, General Medicine, Prognosis, medicine.disease, Vulnerable plaque, Stenosis, Cardiology, Radiology, medicine.symptom, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, computed tomography, intravascular ultrasound, plaque remodeling, vulnerable plaque, Calcification
Abstract

In the absence of a fixed relationship between plaque vulnerability and flow-limiting stenosis, alternative morphological expressions exist that could predict the liability of coronary lesions to rapidly progress or rupture, causing acute coronary syndromes. Modern multidetector computed tomography technology is capable of noninvasively detecting lesion location, attenuation, remodeling and calcification pattern, which may be considered as surrogate morphological markers of vulnerability and could contribute to increase the prognostic value of individual coronary plaque burden. J Cardiovasc Med 10:821 -826 (C) 2009 Italian Federation of Cardiology.

Published
2009

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