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4. MiR-221-3p/222-3p Cluster Expression in Human Adipose Tissue Is Related to Obesity and Type 2 Diabetes

Author

Gentile, Adriana-Mariel, primary, Lhamyani, Said, additional, Mengual-Mesa, María, additional, García-Fuentes, Eduardo, additional, Bermúdez-Silva, Francisco-Javier, additional, Rojo-Martínez, Gemma, additional, Clemente-Postigo, Mercedes, additional, Rodriguez-Cañete, Alberto, additional, Olveira, Gabriel, additional, and El Bekay, Rajaa, additional

Published
2023
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8. The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance

Author

Gutierrez-Repiso, Carolina, Rodriguez-Pacheco, Francisca, Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J, Rodriguez-Cañete, Alberto, Gallego-Perales, Jose L, Alcain-Martinez, Guillermo, Vazquez-Pedreño, Luis, Lopez-Enriquez, Soledad, Garcia-Serrano, Sara, Garrido-Sanchez, Lourdes, and Garcia-Fuentes, Eduardo

Published
2015
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11. Bone mineral density in familial partial lipodystrophy

Author

Fernández‐Pombo, Antía, Ossandon‐Otero, Javier A., Guillín‐Amarelle, Cristina, Sánchez‐Iglesias, Sofía, Castro, Ana I., González‐Méndez, Blanca, Rodríguez‐García, Silvia, Rodriguez‐Cañete, Leticia, Casanueva, Felipe F., and Araújo‐Vilar, David

Published
2018
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13. FNDC5 could be regulated by leptin in adipose tissue

Author

Gutierrez-Repiso, Carolina, Garcia-Serrano, Sara, Rodriguez-Pacheco, Francisca, Garcia-Escobar, Eva, Haro-Mora, Juan J., Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Martinez-Ferriz, Abelardo, Santoyo, Julio S., Perez-Valero, Vidal, and Garcia-Fuentes, Eduardo

Published
2014
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14. Effects of obesity/fatty acids on the expression of GPR120

Author

Rodriguez-Pacheco, Francisca, Garcia-Serrano, Sara, Garcia-Escobar, Eva, Gutierrez-Repiso, Carolina, Garcia-Arnes, Juan, Valdes, Sergio, Gonzalo, Montserrat, Soriguer, Federico, Moreno-Ruiz, Francisco J., Rodriguez-Cañete, Alberto, Gallego-Perales, Jose L., Martinez-Ferriz, Abelardo, Rojo-Martínez, Gemma, and Garcia-Fuentes, Eduardo

Published
2014
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20. Inflammatory myopathy in the context of an unusual overlapping laminopathy

Author

Antonio Mera, Elena Pintos, Ana Castro-Pais, David Araújo-Vilar, Cristina Guillín-Amarelle, Sofía Sánchez-Iglesias, Leticia Rodriguez-Cañete, Julio Pardo, Felipe F. Casanueva, Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, and Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina

Subjects
Premature aging, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, lcsh:RC648-665, business.industry, Endocrinology, Diabetes and Metabolism, Partial Lipodystrophy, lcsh:R, lcsh:Medicine, 030209 endocrinology & metabolism, Laminopathy, medicine.disease, Familial partial lipodystrophy, lcsh:Diseases of the endocrine glands. Clinical endocrinology, LMNA, Inflammatory myopathy, 03 medical and health sciences, 0302 clinical medicine, Medicine, Muscular dystrophy, medicine.symptom, business, Myopathy, 030217 neurology & neurosurgery
Abstract

Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial lipodystrophy [FPLD2]), muscle (type 2 Emery–Dreifuss muscular dystrophy [EDMD2], type 1B limb-girdle muscular dystrophy [LGMD1B], and dilated cardiomyopathy), nerves (type 2B1 Charcot–Marie–Tooth disease), and premature aging syndromes. Moreover, overlapping syndromes have been reported. This study aimed to determine the genetic basis of an overlapping syndrome in a patient with heart disease, myopathy, and features of lipodystrophy, combined with severe metabolic syndrome. We evaluated a 54-year-old woman with rheumatoid arthritis, chronic hypercortisolism (endogenous and exogenous), and a history of cured adrenal Cushing syndrome. The patient presented with a complex disorder, including metabolic syndrome associated with mild partial lipodystrophy (Köbberling-like); mild hypertrophic cardiomyopathy, with Wolff–Parkinson– White syndrome and atrial fibrillation; and limb-girdle inflammatory myopathy. Mutational analysis of the LMNA gene showed a heterozygous c.1634G>A (p.R545H) variant in exon 10 of LMNA. This variant has previously been independently associated with FPLD2, EDMD2, LGMD1B, and heart disease. We describe a new, LMNA-associated, complex overlapping syndrome in which fat, muscle, and cardiac disturbances are related to a p.R545H variant. This work was funded by the Instituto de Salud Carlos III (grant number: PI081449) and the European Regional Development Fund, FEDER. In addition, SRG was awarded a Research Fellowship granted by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP) SI

Published
2018

21. Bone mineral density in familial partial lipodystrophy

Author

Fernández-Pombo, Antía, primary, Ossandon-Otero, Javier A., additional, Guillín-Amarelle, Cristina, additional, Sánchez-Iglesias, Sofía, additional, Castro, Ana I., additional, González-Méndez, Blanca, additional, Rodríguez-García, Silvia, additional, Rodriguez-Cañete, Leticia, additional, Casanueva, Felipe F., additional, and Araújo-Vilar, David, additional

Published
2017
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22. SCD1 expression is associated to free fatty acid levels, but not to SCD1 gene promoter methylation levels in morbid obese patients

Author

Garcia-Fuentes, Eduardo, primary, Garcia-Serrano, Sara, additional, Martín-Nuñez, Gracia, additional, Gutierrez-Repiso, Carolina, additional, Rodriguez-Pacheco, Francisca, additional, Ho-Plagaro, Ailec, additional, Valdes, Sergio, additional, Gonzalo, Montserrat, additional, Moreno-Ruiz, Francisco J., additional, Montiel-Casado, Custodia, additional, Rodriguez-Cañete, Alberto, additional, and Morcillo, Sonsoles, additional

Published
2017
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23. Lactonase activity of HDL is increased in morbidly obese subjects and is associated to atherogenic index of plasma

Author

Garcia-Fuentes, Eduardo, primary, Garcia-Serrano, Sara, additional, Gutierrez-Repiso, Carolina, additional, Rodríguez-Pacheco, Francisca, additional, Ho-Plagaro, Ailec, additional, Valdes, Sergio, additional, Gonzalo, Montserrat, additional, Montiel-Casado, Custodia, additional, Rodriguez-Cañete, Alberto, additional, Moreno-Ruiz, Francisco J., additional, and Alaminos-Castillo, Miguel A., additional

Published
2017
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24. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids

Author

Morcillo, Sonsoles, primary, Martín-Núñez, Gracia Mª, additional, García-Serrano, Sara, additional, Gutierrez-Repiso, Carolina, additional, Rodriguez-Pacheco, Francisca, additional, Valdes, Sergio, additional, Gonzalo, Montserrat, additional, Rojo-Martinez, Gemma, additional, Moreno-Ruiz, Francisco J., additional, Rodriguez-Cañete, Alberto, additional, Tinahones, Francisco, additional, and García-Fuentes, Eduardo, additional

Published
2017
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25. Long-term treatment with pegvisomant for acromegaly: a 10-year experience

Author

Miguel Sampedro-Núñez, Paz de Miguel, Tomás Lucas, Cristina Álvarez-Escolá, Javier Aller, Irene Halperin, Ana M. Ramos-Leví, Mónica Marazuela, Ignacio Bernabeu, Manuel Puig-Domingo, and Leticia Rodriguez-Cañete

Subjects
Adult, Male, medicine.medical_specialty, Long term treatment, Time Factors, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, PEG ratio, Acromegaly, medicine, Humans, Prospective Studies, Insulin-Like Growth Factor I, Prospective cohort study, Aged, business.industry, Human Growth Hormone, Receptors, Somatotropin, Middle Aged, medicine.disease, Menopause, Treatment Outcome, Spain, 030220 oncology & carcinogenesis, Concomitant, Pegvisomant, Observational study, Female, business, medicine.drug, Follow-Up Studies
Abstract

SummaryBackground Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. Objective To re-evaluate the outcomes of long-term PEG in a series of previously published patients and analyse the escape phenomenon. Methods We reviewed all patients with acromegaly resistant to SSA in whom PEG was started as monotherapy, who had been included in a previous publication. We prospectively evaluated 64 (56·3% women) from six tertiary care referral hospitals in Spain, for whom data as of June 2014 were available. Escape to PEG was defined as confirmed loss of biochemical control (IGF-I >1·2xULN), after at least 6 months of previous control with a stable dose of PEG. Results Patients were followed up for 13·0 (5·9–34·8) years since diagnosis, and 9·0 (4·1–10·4) years since the first administration of PEG. Fifty-one (89·5%) patients had an adequate IGF-I control at the last follow-up visit, 9 of them without treatment. Tumour growth was reported in 6 of 64 cases (9·4%), none of whom had received prior radiotherapy (P = 0·011). Seven patients died during follow-up. We found 16 escapes in 10 patients (15·6%). We identified potential underlying causes in 9 cases (tumour regrowth, previous treatment modifications, concomitant menopause and change in testosterone administration). The reason was unknown in 7 escapes, which occurred in 6 patients (9·4%). All patients, except one, achieved subsequent biochemical control after treatment adjustment. Conclusions We reassure the efficacy and safety of long-term PEG. An escape phenomenon may occur, but it can be overcome by adjusting therapy.

Published
2015

29. C-peptide modifies leptin and visfatin secretion in human adipose tissue

Author

Sara, Garcia-Serrano, Carolina, Gutiérrez-Repiso, Montserrat, Gonzalo, Juan, Garcia-Arnes, Sergio, Valdes, Federico, Soriguer, Vidal, Perez-Valero, Miguel A, Alaminos-Castillo, Juan, Francisco Cobos-Bravo, Francisco J, Moreno-Ruiz, Alberto, Rodriguez-Cañete, Francisca, Rodríguez-Pacheco, Eva, Garcia-Escobar, and Eduardo, García-Fuentes

Subjects
Adult, Leptin, Male, Phosphatidylinositol 3-Kinases, Adipokines, Adipose Tissue, C-Peptide, Humans, Female, Glucose Tolerance Test, Nicotinamide Phosphoribosyltransferase
Abstract

The effects of C-peptide on adipose tissue, an organ involved in the development of obesity and insulin resistance, are not yet well known. The aim of this study was to determine whether C-peptide could be involved in the regulation of the adipocytokine synthesis in human visceral adipose tissue.The association between C-peptide and different serum adipocytokines, with an intravenous glucose tolerance test (IVGTT), and in an in vitro study in subjects without obesity and in subjects with morbid obesity were analyzed.In different multiple regression analysis models, C-peptide and C-peptide increase above basal levels during total IVGTT and between 0 and 10 min were associated positively with leptin and negatively with visfatin. Rhodamine-labeled C-peptide binds to human adipocytes, and this binding was blocked with excess of unlabeled C-peptide. Exposure of human visceral explants and adipocytes from subjects with morbid obesity to C-peptide at 1 and 10 nM induced a significant increase in leptin and a decrease in visfatin secretion. In subjects without obesity, these C-peptide effects were found mainly at 10 nM. These effects can be inhibited by phosphatidylinositol 3-kinase (PI3K) or protein kinase B (PKB) inhibitors.C-peptide may be involved in the regulation of leptin and visfatin secretion, molecules intimately involved in energy homeostasis processes, through PI3K or PKB pathways.

Published
2014

30. The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120

Author

Rodriguez-Pacheco, Francisca, primary, Gutierrez-Repiso, Carolina, additional, Garcia-Serrano, Sara, additional, Alaminos-Castillo, Miguel A., additional, Ho-Plagaro, Ailec, additional, Valdes, Sergio, additional, Garcia-Arnes, Juan, additional, Gonzalo, Montserrat, additional, Andrade, Raul J., additional, Moreno-Ruiz, Francisco J., additional, Rodriguez-Cañete, Alberto, additional, Martinez-Ferriz, Abelardo, additional, and Garcia-Fuentes, Eduardo, additional

Published
2016
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32. C-peptide modifies leptin and visfatin secretion in human adipose tissue

Author

Garcia-Serrano, Sara, primary, Gutiérrez-Repiso, Carolina, additional, Gonzalo, Montserrat, additional, Garcia-Arnes, Juan, additional, Valdes, Sergio, additional, Soriguer, Federico, additional, Perez-Valero, Vidal, additional, Alaminos-Castillo, Miguel A., additional, Francisco Cobos-Bravo, Juan, additional, Moreno-Ruiz, Francisco J., additional, Rodriguez-Cañete, Alberto, additional, Rodríguez-Pacheco, Francisca, additional, Garcia-Escobar, Eva, additional, and García-Fuentes, Eduardo, additional

Published
2015
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