29 results on '"Roehr C.C."'
Search Results
2. Respiratory management and bronchopulmonary dysplasia in extremely preterm infants: a comparison of practice between centres in Oxford and Melbourne.
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Sun S., Zivanovic S., Earnest A., Roehr C.C., Tan K., Sun S., Zivanovic S., Earnest A., Roehr C.C., and Tan K.
- Abstract
Objective: Considerable variation in the care of extremely low gestational age infants (ELGAN) contributes to the variation in incidence of bronchopulmonary dysplasia (BPD). We compared management and outcomes of two neonatal centres with different respiratory support strategies. Study design: Retrospective cohort study of infants <28 weeks gestational age treated at two units in Australia and the UK between 2015 and 2017. Result(s): Of 492 infants, the overall incidence of BPD for extremely preterm infants was 62.20% and was similar across both sites (64.84% at Monash vs. 60.65% at Oxford). Independent predictors for the development of BPD or mortality included the days on mechanical ventilation (MV, adjusted OR 1.13, 95% Cl 1.07-1.19) and use of inhaled nitric oxide (adjusted OR 13.42, 95% Cl 1.75-103.28). Conclusion(s): Primary choice of non-invasive respiratory support had no significant impact on BPD development. Duration of MV and using nitric oxide were independent predictors for death or BPD.Copyright © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
- Published
- 2022
3. Spontaneous breathing approach in mild congenital diaphragmatic hernia: A resuscitation algorithm
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Horn-Oudshoorn, E.J.J., Knol, R., Cochius-den Otter, S.C.M., Pas, A.B. Te, Hooper, S.B., Roberts, C.T., Rafat, N., Schaible, T., Boode, W.P. de, Lee, R.T. van der, Debeer, A., Kipfmueller, F., Roehr, C.C., Reiss, I.K.M., DeKoninck, P.L.J., Horn-Oudshoorn, E.J.J., Knol, R., Cochius-den Otter, S.C.M., Pas, A.B. Te, Hooper, S.B., Roberts, C.T., Rafat, N., Schaible, T., Boode, W.P. de, Lee, R.T. van der, Debeer, A., Kipfmueller, F., Roehr, C.C., Reiss, I.K.M., and DeKoninck, P.L.J.
- Abstract
Contains fulltext : 283147.pdf (Publisher’s version ) (Open Access), BACKGROUND: Infants with a congenital diaphragmatic hernia (CDH) and expected mild pulmonary hypoplasia have an estimated survival rate of 90%. Current guidelines for delivery room management do not consider the individual patient's disease severity, but an individualized approach with spontaneous breathing instead of routine mechanical ventilation could be beneficial for the mildest cases. We developed a resuscitation algorithm for this individualized approach serving two purposes: improving the success rate by structuring the approach and providing a guideline for other centers. METHODS: An initial algorithm was discussed with all local stakeholders. Afterwards, the resulting algorithm was refined using input from international experts. RESULTS: Eligible CDH infants: left-sided defect, observed to expected lung-to-head ratio ≥50%, gestational age at birth ≥37.0 weeks, and no major associated structural or genetic abnormalities. To facilitate fetal-to-neonatal transition, we propose to start stabilization with non-invasive respiratory support and to adjust this individually. CONCLUSIONS: Infants with mild CDH might benefit from an individualized approach for neonatal resuscitation. Herein, we present an algorithm that could serve as guidance for centers implementing this.
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- 2022
4. Care practices and outcomes of extremely preterm neonates born at 22–24 weeks – A single centre experience
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Ramaswamy, V.V., primary, Oommen, V.I., additional, Gupta, A., additional, Weerapperuma, N., additional, Zivanovic, S., additional, and Roehr, C.C., additional
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- 2021
- Full Text
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5. Comparison of different techniques to measure air leaks during CPAP treatment in neonates
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Schmalisch, G., Fischer, H., Roehr, C.C., and Proquitté, H.
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- 2009
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6. Corrigendum to “European Resuscitation Council Guidelines 2021: Executive summary” [Resuscitation (2021) 1–60]
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Perkins, Gavin D., primary, Gräsner, Jan-Thortsen, additional, Semeraro, Federico, additional, Olasveengen, Theresa, additional, Soar, Jasmeet, additional, Lott, Carsten, additional, Van de Voorde, Patrick, additional, Madar, John, additional, Zideman, David, additional, Mentzelopoulos, Spyridon, additional, Bossaert, Leo, additional, Greif, Robert, additional, Monsieurs, Koen, additional, Svavarsdóttir, Hildigunnur, additional, Nolan, Jerry P., additional, Ainsworth, S., additional, Deakin, C.D., additional, Lippert, F., additional, Sandroni, C., additional, Akin, S., additional, Delchef, J., additional, Lockey, A.S., additional, Sari, F., additional, Alfonzo, A., additional, Dirks, B., additional, Lott, C., additional, Scapigliati, A., additional, Andres, J., additional, Djakow, J., additional, Lulic, I., additional, Schilder, S., additional, Attard Montalto, S., additional, Djarv, T., additional, Maas, M., additional, Schlieber, J., additional, Barelli, A., additional, Druwe, P., additional, Maconochie, I., additional, Schnaubelt, S., additional, Baubin, M., additional, Eldin, G., additional, Madar, J., additional, Semeraro, F., additional, Behringer, W., additional, Ersdal, H., additional, Martinez-Mejias, A., additional, Shammet, S., additional, Bein, B., additional, Friberg, H., additional, Masterson, S., additional, Singletary, E.M., additional, Biarent, D., additional, Genbrugge, C., additional, Mentzelopoulos, S.D., additional, Skåre, C., additional, Bingham, R., additional, Georgiou, M., additional, Meyran, D., additional, Skrifvars, M.B., additional, Blom, M., additional, Goemans, E., additional, Monsieurs, K.G., additional, Smyth, M., additional, Boccuzzi, A., additional, González-Salvado, V., additional, Morley, C., additional, Soar, J., additional, Borra, V., additional, Gradisek, P., additional, Moulaert, V.R.M., additional, Svavarsdóttir, H., additional, Bossaert, L., additional, Gräsner, J.T., additional, Mpotos, N., additional, Szczapa, T., additional, Böttiger, B.W., additional, Greif, R., additional, Nikolaou, N., additional, Taccone, F., additional, Breckwoldt, J., additional, Handley, A.J., additional, Nolan, J.P., additional, Tageldin Mustafa, M., additional, Brissaud, O., additional, Hassager, C., additional, Olasveengen, T.M., additional, Te Pas, A., additional, Burkart, R., additional, Haywood, K., additional, Oliver, E., additional, Thies, K.C., additional, Cariou, A., additional, Heltne, J.K., additional, Paal, P., additional, Tjelmeland, I.B.M., additional, Carli, P., additional, Hendrickx, D., additional, Pellis, T., additional, Trevisanuto, D., additional, Carmona, F., additional, Herlitz, J., additional, Perkins, G.D., additional, Truhlár, A., additional, Cassan, P., additional, Hinkelbein, J., additional, Pflanzl-Knizacek, L., additional, Trummer, G., additional, Castren, M., additional, Hoffmann, F., additional, Pitches, K., additional, Turner, N.M., additional, Christophides, T., additional, Hunyadi Anticevic, S., additional, Poole, K., additional, Urlesberger, B., additional, Cimpoesu, C.D., additional, Johannesdottir, G.B., additional, Raffay, V., additional, Vaahersalo, J., additional, Clarens, C., additional, Khalifa, G., additional, Renier, W., additional, Van de Voorde, P., additional, Conaghan, P., additional, Klaassen, B., additional, Ristagno, G., additional, Van Grootven, H., additional, Couper, K., additional, Koppl, J., additional, Roehr, C.C., additional, Wilkinson, D., additional, Cronberg, T., additional, Kreimeier, U., additional, Rosell-Ortiz, F., additional, Wnent, J., additional, De Buck, E., additional, Kuzovlev, A., additional, Rüdiger, M., additional, Wyllie, J.P., additional, de Lucas, N., additional, Lauritsen, T., additional, Safri, A., additional, Yeung, J., additional, De Roovere, A., additional, Lilja, G., additional, Sanchez Santos, L., additional, and Zideman, D.A., additional
- Published
- 2021
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7. Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs.
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Roberts C.T., Klink S., Schmolzer G.M., Blank D.A., Badurdeen S., Crossley K.J., Rodgers K., Zahra V., Moxham A., Roehr C.C., Kluckow M., Gill A.W., Hooper S.B., Polglase G.R., Roberts C.T., Klink S., Schmolzer G.M., Blank D.A., Badurdeen S., Crossley K.J., Rodgers K., Zahra V., Moxham A., Roehr C.C., Kluckow M., Gill A.W., Hooper S.B., and Polglase G.R.
- Abstract
OBJECTIVE: Intraosseous access is recommended as a reasonable alternative for vascular access during newborn resuscitation if umbilical access is unavailable, but there are minimal reported data in newborns. We compared intraosseous with intravenous epinephrine administration during resuscitation of severely asphyxiated lambs at birth. METHOD(S): Near-term lambs (139 days' gestation) were instrumented antenatally for measurement of carotid and pulmonary blood flow and systemic blood pressure. Intrapartum asphyxia was induced by umbilical cord clamping until asystole. Resuscitation commenced with positive pressure ventilation followed by chest compressions and the lambs received either intraosseous or central intravenous epinephrine (10 mug/kg); epinephrine administration was repeated every 3min until return of spontaneous circulation (ROSC). The lambs were maintained for 30min after ROSC. Plasma epinephrine levels were measured before cord clamping, at end asphyxia, and at 3 and 15min post-ROSC. RESULT(S): ROSC was successful in 7 of 9 intraosseous epinephrine lambs and in 10 of 12 intravenous epinephrine lambs. The time and number of epinephrine doses required to achieve ROSC were similar between the groups, as were the achieved plasma epinephrine levels. Lambs in both groups displayed a similar marked overshoot in systemic blood pressure and carotid blood flow after ROSC. Blood gas parameters improved more quickly in the intraosseous lambs in the first 3min, but were otherwise similar over the 30min after ROSC. CONCLUSION(S): Intraosseous epinephrine administration results in similar outcomes to intravenous epinephrine during resuscitation of asphyxiated newborn lambs. These findings support the inclusion of intraosseous access as a route for epinephrine administration in current guidelines.Copyright © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
- Published
- 2021
8. Near-infrared spectroscopy for perioperative assessment and neonatal interventions.
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Pellicer A., Neunhoeffer F., Schuhmann M.U., Breindahl M., Fumagelli M., Mintzer J., de Boode W., Alarcon A., Alderliesten T., Austin T., Bruckner M., de Boode W.P., Dempsey G., Ergenekon E., Fumagalli M., Greisen G., Gucuyener K., Hahn G.H., Kalish B.T., Kooi E., Lee-Summers J., Lemmers P., Levy P.T., Liem K.D., Hansen M.L., Martini S., Naulaers G., Pichler G., Rhee C., Roehr C.C., Roll C., Schwarz C.E., da Costa C.S., Szczapa T., Urlesberger B., Wolf M., Wong F., Pellicer A., Neunhoeffer F., Schuhmann M.U., Breindahl M., Fumagelli M., Mintzer J., de Boode W., Alarcon A., Alderliesten T., Austin T., Bruckner M., de Boode W.P., Dempsey G., Ergenekon E., Fumagalli M., Greisen G., Gucuyener K., Hahn G.H., Kalish B.T., Kooi E., Lee-Summers J., Lemmers P., Levy P.T., Liem K.D., Hansen M.L., Martini S., Naulaers G., Pichler G., Rhee C., Roehr C.C., Roll C., Schwarz C.E., da Costa C.S., Szczapa T., Urlesberger B., Wolf M., and Wong F.
- Abstract
Perioperative applications of near-infrared spectroscopy (NIRS) to monitor regional tissue oxygenation and perfusion in cardiac and noncardiac surgery are of increasing interest in neonatal care. Complex neonatal surgery can impair adequate oxygen delivery and tissue oxygen consumption and increase the risk of neurodevelopmental delay. Coupled with conventional techniques, NIRS monitoring may enable targeted hemodynamic management of the circulation in both cardiac and noncardiac surgical procedures. In this narrative review, we discuss the application of perioperative NIRS in specific neonatal interventions, including surgical intervention for congenital heart defects, definitive closure of the patent ductus arteriosus, neurological and gastrointestinal disorders, and use of extracorporeal membrane oxygenation. We identified areas for future research within disease-specific indications and offer a roadmap to aid in developing evidence-based targeted diagnostic and management strategies in neonates. Impact: There is growing recognition that perioperative NIRS monitoring, used in conjunction with conventional monitoring, may provide critical hemodynamic information that either complements clinical impressions or delivers novel physiologic insight into the neonatal circulatory and perfusion pathways.Copyright © 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
- Published
- 2021
9. European Resuscitation Council Guidelines 2021: Executive summary
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Perkins, Gavin D., primary, Gräsner, Jan-Thorsen, additional, Semeraro, Federico, additional, Olasveengen, Theresa, additional, Soar, Jasmeet, additional, Lott, Carsten, additional, Van de Voorde, Patrick, additional, Madar, John, additional, Zideman, David, additional, Mentzelopoulos, Spyridon, additional, Bossaert, Leo, additional, Greif, Robert, additional, Monsieurs, Koen, additional, Svavarsdóttir, Hildigunnur, additional, Nolan, Jerry P., additional, Ainsworth, S., additional, Akin, S., additional, Alfonzo, A., additional, Andres, J., additional, Attard Montalto, S., additional, Barelli, A., additional, Baubin, M., additional, Behringer, W., additional, Bein, B., additional, Biarent, D., additional, Bingham, R., additional, Blom, M., additional, Boccuzzi, A., additional, Borra, V., additional, Bossaert, L., additional, Böttiger, B.W., additional, Breckwoldt, J., additional, Brissaud, O., additional, Burkart, R., additional, Cariou, A., additional, Carli, P., additional, Carmona, F., additional, Cassan, P., additional, Castren, M., additional, Christophides, T., additional, Cimpoesu, C.D., additional, Clarens, C., additional, Conaghan, P., additional, Couper, K., additional, Cronberg, T., additional, De Buck, E., additional, de Lucas, N., additional, De Roovere, A., additional, Deakin, C.D., additional, Delchef, J., additional, Dirks, B., additional, Djakow, J., additional, Djarv, T., additional, Druwe, P., additional, Eldin, G., additional, Ersdal, H., additional, Friberg, H., additional, Genbrugge, C., additional, Georgiou, M., additional, Goemans, E., additional, Gonzalez-Salvado, V., additional, Gradisek, P., additional, Graesner, J.T., additional, Greif, R., additional, Handley, A.J., additional, Hassager, C., additional, Haywood, K., additional, Heltne, J.K., additional, Hendrickx, D., additional, Herlitz, J., additional, Hinkelbein, J., additional, Hoffmann, F., additional, Hunyadi Anticevic, S., additional, Johannesdottir, G.B., additional, Khalifa, G., additional, Klaassen, B., additional, Koppl, J., additional, Kreimeier, U., additional, Kuzovlev, A., additional, Lauritsen, T., additional, Lilja, G., additional, Lippert, F., additional, Lockey, A., additional, Lott, C., additional, Lulic, I., additional, Maas, M., additional, Maconochie, I., additional, Madar, J., additional, Martinez-Mejias, A., additional, Masterson, S., additional, Mentzelopoulos, S.D., additional, Meyran, D., additional, Monsieurs, K.G., additional, Morley, C., additional, Moulaert, V.R.M., additional, Mpotos, N., additional, Nikolaou, N., additional, Nolan, J.P., additional, Olasveengen, T.M., additional, Oliver, E., additional, Paal, P., additional, Pellis, T., additional, Perkins, G.D., additional, Pflanzl-Knizacek, L., additional, Pitches, K., additional, Poole, K., additional, Raffay, V., additional, Renier, W., additional, Ristagno, G., additional, Roehr, C.C., additional, Rosell-Ortiz, F., additional, Rudiger, M., additional, Safri, A., additional, Sanchez Santos, L., additional, Sandroni, C., additional, Sari, F., additional, Scapigliati, A., additional, Schilder, S., additional, Schlieber, J., additional, Schnaubelt, S., additional, Semeraro, F., additional, Shammet, S., additional, Singletary, E.M., additional, Skare, C., additional, Skrifvars, M.B., additional, Smyth, M., additional, Soar, J., additional, Svavarsdottir, H., additional, Szczapa, T., additional, Taccone, F., additional, Tageldin Mustafa, M., additional, Te Pas, A., additional, Thies, K.C., additional, Tjelmeland, I.B.M., additional, Trevisanuto, D., additional, Truhlar, A., additional, Trummer, G., additional, Turner, N.M., additional, Urlesberger, B., additional, Vaahersalo, J., additional, Van de Voorde, P., additional, Van Grootven, H., additional, Wilkinson, D., additional, Wnent, J., additional, Wyllie, J.P., additional, Yeung, J., additional, and Zideman, D.A., additional
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- 2021
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10. Inclusion of children and pregnant women in COVID-19 intervention trials.
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Malhotra A., den Boer M.C., Roehr C.C., Kumar A., Malhotra A., den Boer M.C., Roehr C.C., and Kumar A.
- Published
- 2020
11. The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
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Annink, K.V. (Kim V.), Vries, L.S. (Linda) de, Groenendaal, F. (Floris), Vijlbrief, D.C. (Daniel C.), Weeke, L.C. (Lauren C.), Roehr, C.C. (Charles C.), Leguin, M. (Maarten), Reiss, I.K.M. (Irwin), Govaert, P. (Paul), Benders, J. (Jos), Dudink, J. (Jeroen), Annink, K.V. (Kim V.), Vries, L.S. (Linda) de, Groenendaal, F. (Floris), Vijlbrief, D.C. (Daniel C.), Weeke, L.C. (Lauren C.), Roehr, C.C. (Charles C.), Leguin, M. (Maarten), Reiss, I.K.M. (Irwin), Govaert, P. (Paul), Benders, J. (Jos), and Dudink, J. (Jeroen)
- Abstract
BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed. METHODS: (Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3-7 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3-7 were related to adverse outcome in univariate and the CUS of day 3-7 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II). RESULTS: Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR = 2.6, 95% CI 1.5-4.7) and deep grey matter involvement (OR = 2.7, 95% CI 1.7-4.4). The CUS scoring system performed well in cohort I (AUC = 0.90) and II (AUC = 0.89). CONCLUSION: This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.
- Published
- 2020
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12. European Resuscitation Council COVID-19 guidelines executive summary
- Author
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Nolan, J.P., primary, Monsieurs, K.G., additional, Bossaert, L., additional, Böttiger, B.W., additional, Greif, R., additional, Lott, C., additional, Madar, J., additional, Olasveengen, T.M., additional, Roehr, C.C., additional, Semeraro, F., additional, Soar, J., additional, Van de Voorde, P., additional, Zideman, D.A., additional, Perkins, G.D., additional, Ainsworth, S., additional, Biarent, D., additional, Bingham, B., additional, Blom, M.T., additional, Borra, V., additional, Brissaud, O., additional, Carli, P., additional, Cassan, P., additional, Castrén, M., additional, Cimpoesu, D., additional, Couper, K., additional, Deakin, C.D., additional, Buck, E.De, additional, Lucas, N.De, additional, Djakow, J., additional, Djärv, T., additional, Druwé, P., additional, Ersdal, H., additional, Handley, A., additional, Hoffmann, F., additional, Klaassen, B., additional, Kuzovlev, A., additional, Lauritsen, T., additional, Lilja, G., additional, Lulic, I., additional, Maconochie, I., additional, Martinez, A.M., additional, Mentzelopoulos, S., additional, Meyran, D., additional, Morley, C., additional, Nolan, J.P., additional, Olasveengen, T., additional, Paal, P., additional, Pellis, T., additional, Raffay, V., additional, Ristagno, G., additional, Roehr, C., additional, Rüdiger, M., additional, Sandroni, C., additional, Singletary, E., additional, Skåre, C., additional, Smyth, M., additional, Svavarsdóttir, H., additional, Szczapa, T., additional, Pas, A.te, additional, Trevisanuto, D., additional, Turner, N.M., additional, Urlesberger, B., additional, Voorde, P.Van de, additional, Wilkinson, D., additional, and Wyllie, J., additional
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- 2020
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13. Increasing Respiratory Effort With 100% Oxygen During Resuscitation of Preterm Rabbits at Birth
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Dekker, J. (Janneke), Hooper, S.B. (Stuart B.), Croughan, M.K. (Michelle K.), Crossley, K.J. (Kelly J.), Wallace, M.J. (Megan J.), McGillick, E.V. (Erin V.), DeKoninck, P.L.J. (Philip L. J.), Thio, M. (Marta), Martherus, T. (Tessa), Ruben, G. (Gary), Roehr, C.C. (Charles C.), Cramer, S.J.E. (Sophie J. E.), Flemmer, A.W. (Andreas W.), Croton, L. (Linda), te Pas, A.B. (Arjan B.), Kitchen, M.J. (Marcus J.), Dekker, J. (Janneke), Hooper, S.B. (Stuart B.), Croughan, M.K. (Michelle K.), Crossley, K.J. (Kelly J.), Wallace, M.J. (Megan J.), McGillick, E.V. (Erin V.), DeKoninck, P.L.J. (Philip L. J.), Thio, M. (Marta), Martherus, T. (Tessa), Ruben, G. (Gary), Roehr, C.C. (Charles C.), Cramer, S.J.E. (Sophie J. E.), Flemmer, A.W. (Andreas W.), Croton, L. (Linda), te Pas, A.B. (Arjan B.), and Kitchen, M.J. (Marcus J.)
- Abstract
Background: Spontaneous breathing is essential for successful non-invasive respiratory support delivered by a facemask at birth. As hypoxia is a potent inhibitor of spontaneous breathing, initiating respiratory support with a high fraction of inspired O2 may reduce the risk of hypoxia and increase respiratory effort at birth. Methods: Preterm rabbit kittens (29 days gestation, term ~32 days) were delivered and randomized to receive continuous positive airway pressure with either 21% (n = 12) or 100% O2 (n = 8) via a facemask. If apnea occurred, intermittent positive pressure ventilation (iPPV) was applied with either 21% or 100% O2 in kittens who started in 21% O2, and remained at 100% O2 for kittens who started the experiment in 100% O2. Respiratory rate (breaths per minute, bpm) and variability in inter-breath interval (%) were measured from esophageal pressure recordings and functional residual capacity (FRC) was measured from synchrotron phase-contrast X-ray images. Results: Initially, kittens receiving 21% O2 had a significantly lower respiratory rate and higher variability in inter-breath interval, indicating a less stable breathing pattern than kittens starting in 100% O2 [median (IQR) respiratory rate: 16 (4–28) vs. 38 (29–46) bpm, p = 0.001; variability in inter-breath interval: 33.3% (17.2–50.1%) vs. 27.5% (18.6–36.3%), p = 0.009]. Apnea that required iPPV, was more frequently observed in kittens in whom resuscitation was started with 21% compared to 100% O2 (11/12 vs. 1/8, p = 0.001). After recovering from apnea, respiratory rate was significantly lower and variability in inter-breath interval was significantly higher in kittens who received iPPV with 21% compared to 100% O2. FRC was not different between study groups at both timepoints. Conclusion: Initiating resuscitation with 100% O2 resulted in increased respiratory activity and stability, thereby reducing the risk of apnea and need for iPPV after birth. Further studies in human preterm infants are ma
- Published
- 2019
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14. Care practices and outcomes of extremely preterm neonates born at 22–24 weeks – A single centre experience.
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Ramaswamy, V.V., Oommen, V.I., Gupta, A., Weerapperuma, N., Zivanovic, S., and Roehr, C.C.
- Subjects
NEONATAL intensive care units ,NEWBORN infants ,NEONATAL nursing ,SURVIVAL rate ,VERY low birth weight ,NEONATOLOGISTS ,PERIVENTRICULAR leukomalacia - Abstract
BACKGROUND: Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22
+0 – 24+6 weeks. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others. METHODS: Retrospective study of neonates born at 22+0 –24+6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016–2019). RESULTS: 94 neonates given active care were studied. Survival until discharge was 51.1%(22–23 wks –44%, 24 wks –59.1%) and survival with no major brain injury (MBI) [grade III/IV IVH, cystic periventricular leukomalacia] was 38.3%(22–23 wks –32%, 24 wks –45.4%). Of those who survived until discharge, 75%had no MBI (22–23 wks –72.7%, 24 wks –76.9%). Neonates requiring significant respiratory support within first 72 hours as well as needing rescue high frequency ventilation had significantly high risk of mortality or MBI [aOR –7.17 (2.24–25.79), p = 0.00; 4.76 (1.43–20.00), p = 0.01]. CONCLUSIONS: Survival rate differed from other centres. MBI was low amongst survivors. Severe respiratory disease in the initial days was associated with a higher risk of death or MBI. [ABSTRACT FROM AUTHOR]- Published
- 2021
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15. Does treatment with Echinacea purpurea effectively shorten the course of upper respiratory tract infections in children?
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Phillips, Bob, Koenig, K., and Roehr, C.C.
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Echinacea -- Usage ,Echinacea -- Health aspects ,Echinacea -- Research ,Alternative medicine -- Usage ,Alternative medicine -- Research ,Pediatric respiratory diseases -- Care and treatment ,Pediatric respiratory diseases -- Research - Published
- 2006
16. Comprehensive state-of-the-art overview of neonatologist performed echocardiography: Steps towards standardization of the use of echocardiography in neonatal intensive care
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Boode, W.P. de, Roehr, C.C., El-Khuffash, A., Boode, W.P. de, Roehr, C.C., and El-Khuffash, A.
- Abstract
Item does not contain fulltext
- Published
- 2018
17. The Use of Peritoneal Dialysis in Phenobarbitone Toxicity in a Critically Unwell Neonate.
- Author
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Graudins A., Le Page A.K., Stewart A.E., Roehr C.C., Johnstone L.M., Graudins A., Le Page A.K., Stewart A.E., Roehr C.C., and Johnstone L.M.
- Abstract
Background: Phenobarbitone (PB) is the first-line anti-convulsant for neonatal seizures. The use of peritoneal dialysis (PD) to enhance drug elimination in cases of neonatal PB overdose has not been reported. Objective(s): To report a case of neonatal severe PB toxicity and review the elimination of PB by PD. Method(s): Assessment of PD drug clearance. Result(s): A neonate with prolonged seizures was administered PB. Encephalopathy and myocardial failure developed, which were initially suspected to be secondary to hypoxia. At 42 h of age, the serum PB concentration was in the toxic range at 131 mg/L. Despite supportive care, the infant's condition deteriorated with escalating inotropes and the need for CPR. Enhanced PB elimination via multiple-dose activated charcoal and exchange transfusion were considered too risky. Hourly PD cycles via Tenckhoff catheter were commenced, based on reports suggesting that PD enhances PB clearance. The clinical state of the infant then improved. PD administration was continued for 60 h, recovering 20% of the estimated total PB body load. The infant survived and there were no PD complications. Conclusion(s): PD increased PB clearance in this neonate, correlating with clinical recovery. Where other techniques are not possible, PD may have a role to play in enhancing PB elimination.Copyright © 2017 S. Karger AG, Basel.
- Published
- 2018
18. Education, training, and accreditation of Neonatologist Performed Echocardiography in Europe-framework for practice
- Author
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Singh, Y., Roehr, C.C., Tissot, C., Rogerson, S., Gupta, S., Bohlin, K., Breindahl, M., El-Khuffash, A., Boode, W.P. de, Singh, Y., Roehr, C.C., Tissot, C., Rogerson, S., Gupta, S., Bohlin, K., Breindahl, M., El-Khuffash, A., and Boode, W.P. de
- Abstract
Item does not contain fulltext, There is a growing interest worldwide in using echocardiography in the neonatal unit to act as a complement to the clinical assessment of the hemodynamic status of premature and term infants. However, there is a wide variation in how this tool is implemented across many jurisdictions, the level of expertise, including the oversight of this practice. Over the last 5 years, three major expert consensus statements have been published to provide guidance to neonatologists performing echocardiography, with all recommending a structured training program and clinical governance system for quality assurance. Neonatal practice in Europe is very heterogeneous and the proximity of neonatal units to pediatric cardiology centers varies significantly. Currently, there is no overarching governance structure for training and accreditation in Europe. In this paper, we provide a brief description of the current training recommendations across several jurisdictions including Europe, North America, and Australia and describe the steps required to achieve a sustainable governance structure with the responsibility to provide accreditation to neonatologist performed echocardiography in Europe.
- Published
- 2018
19. When should resuscitation at birth cease?
- Author
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McGrath, J.S., primary, Roehr, C.C., additional, and Wilkinson, D.J.C., additional
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- 2016
- Full Text
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20. Cardiovascular transition at birth: A physiological sequence.
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Roehr C.C., Kluckow M., Polglase G.R., Wallace E.M., Gill A.W., Hooper S.B., Te Pas A.B., Lang J., Van Vonderen J.J., Roehr C.C., Kluckow M., Polglase G.R., Wallace E.M., Gill A.W., Hooper S.B., Te Pas A.B., Lang J., and Van Vonderen J.J.
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- 2015
21. Training staff in the application of bi-nasal continuous positive airway pressure (CPAP) decreases the rate of serious adverse events (SAE) in very low birth weight infants (VLBWI).
- Author
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Schmalisch G., Roehr C.C., Wauer R.R., Donat T., Schmalisch G., Roehr C.C., Wauer R.R., and Donat T.
- Abstract
Background: Bi-nasal CPAP (bi-nCPAP) is more effective than mononasal CPAP (m-nCPAP) in preterm infants. Serious adverse events (SAEs) to bi-nCPAP include nasal erythema, skin erosions and necrosis. Proponents of m-nCPAP claim it causes less SAEs. We aimed to a) investigate if SAEs to CPAP differed between bi-nCPAP and m-nCPAP, b) if risk factors for SAEs could be identified, and c) if training staff on the use of bi-nCPAP decreased SAEs. Method(s): Observational study (2003-2009) performed in a tertiary neonatal intensive care unit which traditionally employed m-nCPAP and transitioned to bi-nCPAP. Regular staff training on application of bi-nCPAP was commenced alongside a new protocol mandating moving to m-nCPAP if SAEs on bi-nCPAP occurred. SAEs were prospectively documented in patient notes. Data were retrospectively analyzed (2003- 04; 2005-07; 2008-09). Result(s): 413 VLBWI, mean(SD) gestational age (GA) 28.6 weeks (26.7- 30.4), mean(SD) birth weight (BW) 990 g (780-1280) were studied. There was no significant difference in duration of either CPAP application. Compared to m-nCPAP, infants on bi-nCPAP had more nasal blanching and erythema (68.0% vs. 37.3%, p < 0.001), nasal erosion/ necrosis were more common with m-nCPAP (51.4% vs. 30%, p = 0.009). Risk factors: low GA, low BW and length of CPAP (p < 0.001). The median (IQR) SAEs/ patient decreased over time: 2003-2004 (n = 117): 6 (4-6), 2005-2007 (n = 186): 5 (4-6), 2008-2009 (n = 110): 4 (3-5), (p < 0.001). Trained staff showed greater awareness towards early recognition of SAEs. Conclusion(s): Both forms of nCPAP were associated with SAEs. Training resulted in timely recognition of SAEs and appropriate actions, potentially reducing the number of SAEs/patient.
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- 2014
22. Adverse cardiorespiratory events following primary vaccination of very low birth weight infants
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Meinus, C., primary, Schmalisch, G., additional, Hartenstein, S., additional, Proquitté, H., additional, and Roehr, C.C., additional
- Published
- 2012
- Full Text
- View/download PDF
23. Leak during Manual Neonatal Ventilation and Its Effect on the Delivered Pressures and Volumes: An in vitro Study
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Hartung, J.C., primary, te Pas, A.B., additional, Fischer, H., additional, Schmalisch, G., additional, and Roehr, C.C., additional
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- 2012
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24. Neonatal resuscitation and respiratory support in prevention of bronchopulmonary dysplasia
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Roehr, C.C., primary and Bohlin, K., additional
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- 2011
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25. 2158
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Bamberg, C., primary, Kalache, K., additional, Roehr, C.C., additional, Bergann, A., additional, and Bollmann, R., additional
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- 2006
- Full Text
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26. Letter to the Editor
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Roehr, C.C., primary, Reibel, S., additional, and Niggemann, B., additional
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- 2001
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27. Food allergy and non-allergic food hypersensitivity in children and adolescents.
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Roehr, C.C., Edenharter, G., Reimann, S., Ehlers, I., Worm, M., Zuberbier, T., and Niggemann, B.
- Subjects
- *
FOOD allergy , *FOOD allergy in children , *DISEASES in teenagers , *SKIN tests - Abstract
Previous studies have shown a 10-fold discrepancy of self-reported food-induced symptoms and physician-diagnosed food hypersensitivity. Little information is available on the prevalence of food hypersensitivity in unselected paediatric populations. No data were available for German children.To study the perception of food-induced symptoms in the paediatric population, to investigate the allergens accused, to objectify patients' reports, and to identify subgroups at risk of having food-induced allergy (FA) or non-allergic food hypersensitivity (NAFH) reactions.This paper presents the data of the paediatric group (0–17 years) of a representative, randomly sampled, cross-sectional population-based survey studying 13 300 inhabitants of the German capital city Berlin regarding food-related symptoms. Instruments included mailed questionnaires, structured telephone interviews, physical examination, skin-prick tests, specific serum IgE and standardized, controlled and blinded oral food challenges.Two thousand three hundred and fifty-four individuals were contacted by mailed questionnaire, 739 (31.4%) responses could be fully evaluated. Four hundred and fifty-five (61.5%) participants reported symptoms related to food ingestion, 284 (38.4%) affirmed reproducible symptoms in the standardized telephone interview. One hundred and eighty-four (24.8%) individuals were fully examined. Reproducible symptoms to food were found in 31 (4.2%) children and adolescents: 26 (3.5%) showed symptoms of FA and five (0.7%) of NAFH. The oral allergy syndrome was most often observed. Foods most commonly identified by oral challenges were apple, hazelnut, soy, kiwi, carrot and wheat.The perception of food-related symptoms is common among children and adolescents from the general population. Self-reports could be confirmed in around one out of 10 individuals, still resulting in 4.2% of proven clinical symptoms. However, most reactions were mild and mainly because of pollen-associated FA, while NAFH reactions were less common. Severe IgE-mediated FA was observed in individuals with pre-existing atopic disease, who should be fully investigated for clinically relevant FA. [ABSTRACT FROM AUTHOR]
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- 2004
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28. Original article Prevalence of adverse reactions to food in Germany – a population study.
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Zuberbier, T., Edenharter, G., Worm, M., Ehlers, I., Reimann, S., Hantke, T., Roehr, C.C., Bergmann, K.E., and Niggemann, B.
- Subjects
FOOD allergy ,DEMOGRAPHIC surveys ,PLACEBOS ,CONFIDENCE intervals ,ALLERGIES - Abstract
A population study was performed to identify the prevalence of all kinds of adverse reactions to food. In a representative cross-sectional survey performed in 1999 and 2000 in Berlin, 13 300 inhabitants of all ages were addressed by questionnaire. This questionnaire was answered by 4093 persons. All respondents mentioning any sign of food intolerance or the existence of allergic diseases ( n = 2298) were followed up by telephone and, in case food intolerance could not be ruled out by patient history, were invited to attend to the clinic for personal investigation including double-blind, placebo-controlled food challenge tests (DBPCFC). The self-reported lifetime prevalence of any adverse reaction to food in the Berlin population (mean age 41 years) was 34.9%. Eight hundred and fourteen individuals were personally investigated according to the guidelines. The point prevalence of adverse reactions to food confirmed by DBPCFC tests in the Berlin population as a mean of all age groups was 3.6% (95% confidence interval [3.0–4.2%]) and 3.7% in the adult population (18–79 years, 95% confidence interval [3.1–4.4.%]). Two and a half percent were IgE-mediated and 1.1% non-IgE-mediated, females were more frequently affected (60.6%). Based on a statistical comparison with available data of adults from the nationwide German Health Survey from 1998, adverse reactions to food in the adult population of Germany (age 18–79) were calculated with 2.6% [2.1–3.2%]). The study gives for the first time information about the point prevalence of both immunological and nonimmunological adverse reactions to food and underlines the relevance of this issue in public health. The data also show that an individualized stepwise approach including provocation tests is mandatory to confirm the diagnosis. [ABSTRACT FROM AUTHOR]
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- 2004
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29. 2158: Is the prognosis in fetuses with congenital diaphragmatic hernia influenced by the prenatal position and axis of the heart?
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Bamberg, C., Kalache, K., Roehr, C.C., Bergann, A., and Bollmann, R.
- Published
- 2006
- Full Text
- View/download PDF
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