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283 results on '"Roelen, D."'

3. Early Conversion to Prednisolone/Everolimus as an Alternative Weaning Regimen Associates With Beneficial Renal Transplant Histology and Function: The Randomized-Controlled MECANO Trial

Author

Bemelman, F.J., de Fijter, J.W., Kers, J., Meyer, C., Peters-Sengers, H., de Maar, E.F., van der Pant, K.A.M.I., de Vries, A.P.J., Sanders, J.-S., Zwinderman, A., Idu, M.M., Berger, S., Reinders, M.E.J., Krikke, C., Bajema, I.M., van Dijk, M.C., ten Berge, I.J.M., Ringers, J., Lardy, J., Roelen, D., Moes, D.-J., Florquin, S., and Homan van der Heide, J.J.

Published
2017
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4. The detrimental effect of donor-specific antibodies is irrespective of its level in highly-immunized living donor kidney transplant recipients:A case-control series

Author

Tramper, T, Roelen, D L, Brand-Schaaf, S H, Kal-van Gestel, J A, Kho, M M L, Reinders, M E J, Roodnat, J I, van de Wetering, J, Betjes, M G H, de Weerd, A E, Tramper, T, Roelen, D L, Brand-Schaaf, S H, Kal-van Gestel, J A, Kho, M M L, Reinders, M E J, Roodnat, J I, van de Wetering, J, Betjes, M G H, and de Weerd, A E

Abstract

BACKGROUND: The impact of donor-specific antibodies (DSA) in (highly-) immunized living donor kidney transplant recipients is reported differentially in various patient cohorts.METHODS: We have performed a retrospective analysis of all consecutive HLA-incompatible living donor kidney transplant recipients in our center between 2010-2019. Recipients who underwent plasmafiltration for a positive CDC-crossmatch were excluded. For each DSA+ recipient (DSA+), one immunized recipient without DSA (pPRA+) and two non-immunized recipients (pPRA-) were included. Patient and graft survival were analyzed and a subgroup analysis of DSA+ recipients was performed.RESULTS: For 63 DSA+ recipients, 63 PRA+ and 126 PRA- recipients were included. 26 (41%) had class I, 24 (38%) class II and 13 (21%) combined HLA class I and II DSA. Death-censored graft survival was inferior in DSA+ recipients compared to pPRA+ (HR 2.38 [95% CI 1.00-5.70]) as well as to pPRA- (HR 3.91 [1.86-8.22]). In multivariate analysis, DSA remained of negative influence on death-censored graft survival. Flowcytometric crossmatch, MFI value, HLA class and origin of DSA were not of significant impact.CONCLUSION: In our cohort of (highly-) immunized recipients, pretransplant DSA led to inferior death-censored graft survival. There were no "safe" DSA characteristics since only DSA per se impacted death-censored graft survival.

Published
2023

5. The detrimental effect of donor-specific antibodies is irrespective of its level in highly-immunized living donor kidney transplant recipients: A case-control series

Author

Tramper, T., primary, Roelen, D. L., additional, Brand-Schaaf, S. H., additional, Kal-van Gestel, J. A., additional, Kho, M. M. L., additional, Reinders, M. E. J., additional, Roodnat, J. I., additional, van de Wetering, J., additional, Betjes, M. G. H., additional, and de Weerd, A. E., additional

Published
2023
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10. The detrimental effect of donorspecific antibodies is irrespective of its level in highlyimmunized living donor kidney transplant recipients: A case-control series.

Author

Tramper, T., Roelen, D. L., Brand-Schaaf, S. H., Gestel, J. A. Kal-van, Kho, M. M. L., Reinders, M. E. J., Roodnat, J. I., de Wetering, J. van, Betjes, M. G. H., and de Weerd, A. E.

Subjects
KIDNEY transplantation, GRAFT survival, IMMUNOGLOBULINS, MULTIVARIATE analysis
Abstract

Background: The impact of donor-specific antibodies (DSA) in (highly-) immunized living donor kidney transplant recipients is reported differentially in various patient cohorts. Methods: We have performed a retrospective analysis of all consecutive HLAincompatible living donor kidney transplant recipients in our center between 2010-2019. Recipients who underwent plasmafiltration for a positive CDCcrossmatch were excluded. For each DSA+ recipient (DSA+), one immunized recipient without DSA (pPRA+) and two non-immunized recipients (pPRA-) were included. Patient and graft survival were analyzed and a subgroup analysis of DSA+ recipients was performed. Results: For 63 DSA+ recipients, 63 PRA+ and 126 PRA- recipients were included. 26 (41%) had class I, 24 (38%) class II and 13 (21%) combined HLA class I and II DSA. Death-censored graft survival was inferior in DSA+ recipients compared to pPRA+ (HR 2.38 [95% CI 1.00-5.70]) as well as to pPRA- (HR 3.91 [1.86-8.22]). In multivariate analysis, DSA remained of negative influence on death-censored graft survival. Flowcytometric crossmatch, MFI value, HLA class and origin of DSA were not of significant impact. Conclusion: In our cohort of (highly-) immunized recipients, pretransplant DSA led to inferior death-censored graft survival. There were no "safe" DSA characteristics since only DSA per se impacted death-censored graft survival. [ABSTRACT FROM AUTHOR]

Published
2023
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27. The Functional Polymorphism Ala258Ser in Ficolin-2 in the Donor Kidney Predicts Improved Renal Transplant Outcome.: Abstract# 976 Poster Board #-Session: P141-II

Author

Eikmans, M., de Canck, I., van der Pol, P., Baan, C. C., Haasnoot, G. W., Mallat, M. J. K., Vergunst, M., de Meester, E., Roodnat, J. I., Anholts, J. D. H., van Thielen, M., Doxiadis, I. I. N., De Fijter, H. W., van der Linden, C. J. E., van Beelen, E., Van Kooten, C., Gestel, Kal-van J., Peeters, A. M. A., Weimar, W., Roelen, D. L., Rossau, R., and Claas, F. H. J.

Published
2012

30. A functional polymorphism in Ficolin-2 in the donor kidney is associated with improved renal transplant outcome: O36

Author

Eikmans, M., de Canck, I., van der Pol, P., Baan, C. C., Haasnoot, G. W., Mallat, M. J. K., Bryson-Vergunst, M., de Meester, E., Roodnat, J. I., Anholts, J. D. H., van Thielen, M., Doxiadis, I. I. N., de Fijter, H. W., van der Linden, P. J. E., van Beelen, E., van Kooten, C., Kal-van Gestel, J., Peeters, A. M. A., Weimar, W., Roelen, D. L., Rossau, R., and Claas, F. H. J.

Published
2011

47. Decreased Graft Survival of Retransplants can Largely be Explained By Increased Hla-immunization

Author

Kamburova, Elena G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, Eric, Hack, C. E., van Reekum, F., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Plaisier, L., Seelen, M. A. J., Sanders, J. S. F., Hepkema, B. G., Lambeck, A. J., Bungener, L. B., Roozendaal, C., Tilanus, M. G. J., Voorter, C. E., Wieten, L., van Duijnhoven, E., Gelens, M., Christiaans, M., van Ittersum, F., Nurmohamed, A., Lardy, N. M., Swelsen, W. T., van der Pant, K. A. M. I., van der Weerd, N. C., ten Berge, I. J. M., Bemelman, F. J., Hoitsma, A. J., van der Boog, P. J. M., de Fijter, J. W., Betjes, M. G. H., Heidt, Sebastiaan, Roelen, D. L., Claas, F. H. J., Otten, H. G., Groningen Institute for Organ Transplantation (GIOT), and Groningen Kidney Center (GKC)

Published
2018

48. Presence of intragraft B cells during acute renal allograft rejection is accompanied by changes in peripheral blood B cell subsets

Author

Heidt, S, primary, Vergunst, M, additional, Anholts, J D H, additional, Swings, G M J S, additional, Gielis, E M J, additional, Groeneweg, K E, additional, Witkamp, M J, additional, de Fijter, J W, additional, Reinders, M E J, additional, Roelen, D L, additional, Eikmans, M, additional, and Claas, F H J, additional

Published
2019
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49. T cell sensitization and graft rejection

Author

Claas, F., Roelen, D., Vaessen, L., Weimar, W., Touraine, J. L., editor, Traeger, J., editor, Bétuel, H., editor, Dubernard, J. M., editor, Revillard, J. P., editor, and Dupuy, C., editor

Published
1997
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50. Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant

Author

Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., Otten, H. G., Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C.A.D., Plaisier, L., Seelen, M. A.J., Sanders, J. S.F., Hepkema, B. G., Lambeck, A. J.A., Bungener, L. B., Roozendaal, C., Tilanus, M. G.J., Voorter, C. E., Wieten, L., van Duijnhoven, E. M., Gelens, M., Christiaans, M. H.L., van Ittersum, F. J., Nurmohamed, S. A., Lardy, N. M., Swelsen, W., van der Pant, K. A., van der Weerd, N. C., ten Berge, I. J.M., Bemelman, F. J., Hoitsma, A., van der Boog, P. J.M., de Fijter, J. W., Betjes, M. G.H., Heidt, S., Roelen, D. L., Claas, F. H., and Otten, H. G.

Published
2018

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