18 results on '"Roest, I."'
Search Results
2. The effectiveness of immediate versus delayed tubal flushing with oil-based contrast in women with unexplained infertility (H2Oil-timing study): study protocol of a randomized controlled trial
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Kamphuis, D., Rosielle, K., van Welie, N., Roest, I., van Dongen, A. J.C.M., Brinkhuis, E. A., Bourdrez, P., Mozes, A., Verhoeve, H. R., van der Ham, D. P., Vrouenraets, F. P.J.M., Risseeuw, J. J., van de Laar, T., Janse, F., den Hartog, J. E., de Hundt, M., Hooker, A. B., Huppelschoten, A. G., Pieterse, Q. D., Bongers, M. Y., Stoker, J., Koks, C. A.M., Lambalk, C. B., Hemingway, A., Li, W., Mol, B. W.J., Dreyer, K., and Mijatovic, V.
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- 2023
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3. Oil-based versus water-based contrast media for hysterosalpingography in infertile women of advanced age, with ovulation disorders or a high risk for tubal pathology: study protocol of a randomized controlled trial (H2Oil2 study)
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Rosielle, K., Kamphuis, D., van Welie, N., Roest, I., Mozes, A., van Santbrink, E. J. P., van de Laar, T., Hooker, A. B., Huppelschoten, A. G., Li, W., Bongers, M. Y., Stoker, J., van Wely, M., Koks, C., Lambalk, C. B., Hemingway, A., Mol, B. W. J., Dreyer, K., and Mijatovic, V.
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- 2022
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4. The effectiveness of immediate versus delayed tubal flushing with oil-based contrast in women with unexplained infertility (H2Oil-timing study):study protocol of a randomized controlled trial
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Kamphuis, D., Rosielle, K., van Welie, N., Roest, I., van Dongen, A. J. C. M., Brinkhuis, E. A., Bourdrez, P., Mozes, A., Verhoeve, H. R., van der Ham, D. P., Vrouenraets, F. P. J. M., Risseeuw, J. J., van de Laar, T., Janse, F., den Hartog, J. E., de Hundt, M., Hooker, A. B., Huppelschoten, A. G., Pieterse, Q. D., Bongers, M. Y., Stoker, J., Koks, C. A. M., Lambalk, C. B., Hemingway, A., Li, W., Mol, B. W. J., Dreyer, K., Mijatovic, V., Radiology and Nuclear Medicine, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), and ACS - Atherosclerosis & ischemic syndromes
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Fallopian tubes ,HYSTEROSALPINGOGRAPHY ,Obstetrics and Gynecology ,Tubal flushing ,General Medicine ,LIPIODOL ,Hysterosalpingography (HSG) ,Oil-based contrast medium ,Reproductive Medicine ,Fertility work-up ,Pregnancy ,Randomized controlled trial ,Infertility ,Live birth ,Cost-effectiveness - Abstract
Background In women with unexplained infertility, tubal flushing with oil-based contrast during hysterosalpingography leads to significantly more live births as compared to tubal flushing with water-based contrast during hysterosalpingography. However, it is unknown whether incorporating tubal flushing with oil-based contrast in the initial fertility work-up results to a reduced time to conception leading to live birth when compared to delayed tubal flushing that is performed six months after the initial fertility work-up. We also aim to evaluate the effectiveness of tubal flushing with oil-based contrast during hysterosalpingography versus no tubal flushing in the first six months of the study. Methods This study will be an investigator-initiated, open-label, international, multicenter, randomized controlled trial with a planned economic analysis alongside the study. Infertile women between 18 and 39 years of age, who have an ovulatory cycle, who are at low risk for tubal pathology and have been advised expectant management for at least six months (based on the Hunault prediction score) will be included in this study. Eligible women will be randomly allocated (1:1) to immediate tubal flushing (intervention) versus delayed tubal flushing (control group) by using web-based block randomization stratified per study center. The primary outcome is time to conception leading to live birth with conception within twelve months after randomization. We assess the cumulative conception rate at six and twelve months as two co-primary outcomes. Secondary outcomes include ongoing pregnancy rate, live birth rate, miscarriage rate, ectopic pregnancy rate, number of complications, procedural pain score and cost-effectiveness. To demonstrate or refute a shorter time to pregnancy of three months with a power of 90%, a sample size of 554 women is calculated. Discussion The H2Oil-timing study will provide insight into whether tubal flushing with oil-based contrast during hysterosalpingography should be incorporated in the initial fertility work-up in women with unexplained infertility as a therapeutic procedure. If this multicenter RCT shows that tubal flushing with oil-based contrast incorporated in the initial fertility work-up reduces time to conception and is a cost-effective strategy, the results may lead to adjustments of (inter)national guidelines and change clinical practice. Trial registration number The study was retrospectively registered in International Clinical Trials Registry Platform (Main ID: EUCTR2018-004153-24-NL).
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- 2023
5. Additional file 2 of The effectiveness of immediate versus delayed tubal flushing with oil-based contrast in women with unexplained infertility (H2Oil-timing study): study protocol of a randomized controlled trial
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Kamphuis, D., Rosielle, K., van Welie, N., Roest, I., van Dongen, A. J.C.M., Brinkhuis, E. A., Bourdrez, P., Mozes, A., Verhoeve, H. R., van der Ham, D. P., Vrouenraets, F. P.J.M., Risseeuw, J. J., van de Laar, T., Janse, F., den Hartog, J. E., de Hundt, M., Hooker, A. B., Huppelschoten, A. G., Pieterse, Q. D., Bongers, M. Y., Stoker, J., Koks, C. A.M., Lambalk, C. B., Hemingway, A., Li, W., Mol, B. W.J., Dreyer, K., and Mijatovic, V.
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Supplementary Material 2: List of participating sites.
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- 2023
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6. Additional file 1 of The effectiveness of immediate versus delayed tubal flushing with oil-based contrast in women with unexplained infertility (H2Oil-timing study): study protocol of a randomized controlled trial
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Kamphuis, D., Rosielle, K., van Welie, N., Roest, I., van Dongen, A. J.C.M., Brinkhuis, E. A., Bourdrez, P., Mozes, A., Verhoeve, H. R., van der Ham, D. P., Vrouenraets, F. P.J.M., Risseeuw, J. J., van de Laar, T., Janse, F., den Hartog, J. E., de Hundt, M., Hooker, A. B., Huppelschoten, A. G., Pieterse, Q. D., Bongers, M. Y., Stoker, J., Koks, C. A.M., Lambalk, C. B., Hemingway, A., Li, W., Mol, B. W.J., Dreyer, K., and Mijatovic, V.
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Supplementary Material 1: Trial registration data set.
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- 2023
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7. Tubal flushing with oil-based contrast during transvaginal hydro laparoscopy, a case report
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Roest, I. and Roest, I.
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Background: Oil-based contrast has been shown to have a fertility-enhancing effect during hysterosalpingography (HSG) but is not yet used during transvaginal hydro laparoscopy (THL).Objective: To asses if additional tubal flushing with oil-based contrast during THL is feasible.Materials and methods: Case report with video assessment. A healthy 29-year-old woman with primary unexplained subfertility, underwent a THL under local anaesthesia. First, chromopertubation was performed by methylene blue. Afterwards, tubal flushing with 3mL oil-based contrast (Lipiodol (R) UltraFluid, Guerbet) was performed.Main outcome measures: In this case report we evaluated the feasibility of additional tubal flushing with oil-based contrast during THL, in terms of; the visibility of the oil-based contrast at the tubal limbriae, the pain and acceptability scores.Results: Both fallopian tubes were patent to methylene-blue as well as to oil-based contrast. Interestingly, the oil-based contrast came out of the fallopian tube in the form of free droplets with strong internal bonding. Furthermore, some residue of the droplets was visible on the surface of the peritoneal wall in the form of oily micro-droplets.Conclusions: We present the first sub-fertile woman, in which additional tubal flushing with oil-based contrast during THL was performed. It is likely, that the residue of oily micro-droplets is also present inside the fallopian tube, where it may enhance the cilia movement by introducing lubrication. These lubricating characteristics of the oil-based contrast may be important for its fertility-enhancing effect. More research is necessary to confirm this hypothesis and the feasibility of tubal flushing with oil-based contrast during THL in more women.
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- 2022
8. Tubal flushing with oil-based contrast during transvaginal hydro laparoscopy, a case report
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Roest, I, primary, Hajiyavand, A.M., additional, Dearn, K.D., additional, Bongers, M.Y., additional, Mijatovic, V, additional, Mol, B.W.J., additional, and Koks, C.A.M., additional
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- 2022
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9. Additional file 2 of Oil-based versus water-based contrast media for hysterosalpingography in infertile women of advanced age, with ovulation disorders or a high risk for tubal pathology: study protocol of a randomized controlled trial (H2Oil2 study)
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Rosielle, K., Kamphuis, D., van Welie, N., Roest, I., Mozes, A., van Santbrink, E. J. P., van de Laar, T., Hooker, A. B., Huppelschoten, A. G., Li, W., Bongers, M. Y., Stoker, J., van Wely, M., Koks, C., Lambalk, C. B., Hemingway, A., Mol, B. W. J., Dreyer, K., and Mijatovic, V.
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Additional file 2. List of currently participating centres of H2Oil2 as per March 1st 2022 and their local head investigators
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- 2022
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10. Additional file 1 of Oil-based versus water-based contrast media for hysterosalpingography in infertile women of advanced age, with ovulation disorders or a high risk for tubal pathology: study protocol of a randomized controlled trial (H2Oil2 study)
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Rosielle, K., Kamphuis, D., van Welie, N., Roest, I., Mozes, A., van Santbrink, E. J. P., van de Laar, T., Hooker, A. B., Huppelschoten, A. G., Li, W., Bongers, M. Y., Stoker, J., van Wely, M., Koks, C., Lambalk, C. B., Hemingway, A., Mol, B. W. J., Dreyer, K., and Mijatovic, V.
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Additional file 1. Table S1: Description of data: WHO Trial registration data set
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- 2022
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11. Thyroid function in neonates conceived after hysterosalpingography with iodinated contrast.
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van Welie, N, Roest, I, Portela, M, van Rijswijk, J, Koks, C, Lambalk, C B, Dreyer, K, Mol, B W J, Finken, M J J, Mijatovic, V, and H2Oil Study Group
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BIRTH rate , *HYSTEROSALPINGOGRAPHY , *CONTRAST media , *RETROSPECTIVE studies , *THYROID gland - Abstract
Study Question: Does exposure to preconceptional hysterosalpingography (HSG) with iodinated oil-based contrast affect neonatal thyroid function as compared to iodinated water-based contrast?Summary Answer: Preconceptional HSG with iodinated contrast did not influence the neonatal thyroid function.What Is Known Already: HSG is a commonly applied tubal patency test during fertility work-up in which either oil- or water-based contrast is used. Oil-based contrast contains more iodine compared to water-based contrast. A previous study in an East Asian population found an increased risk of congenital hypothyroidism (CH) in neonates whose mothers were exposed to high amounts of oil-based contrast during HSG.Study Design, Size, Duration: This is a retrospective data analysis of the H2Oil study, a randomized controlled trial (RCT) comparing HSG with the use of oil- versus water-based contrast during fertility work-up. After an HSG with oil-based contrast, 214 women had an ongoing pregnancy within 6 months leading to a live birth compared to 155 women after HSG with water-based contrast.Participants/materials, Setting, Methods: Of the 369 women who had a live born infant, 208 consented to be approached for future research and 138 provided informed consent to collect data on the thyroid function tests of their offspring (n = 140). Thyroid function tests of these children were retrieved from the Dutch neonatal screening program, which includes the assessment of total thyroxine (T4) in all newborns, followed by thyroid-stimulating hormone only in those with a T4 level of ≤ -0.8 SD score. Furthermore, amount of contrast medium used and time between HSG and conception were compared between the two study groups.Main Results and the Role Of Chance: Data were collected from 140 neonates conceived after HSG with oil-based (n = 76) or water-based (n = 64) contrast. The median T4 concentration was 87.0 nmol/l [76.0-96.0] in the oil group and 90.0 nmol/l [78.0-106.0] in the water group (P = 0.13). None of the neonates had a positive screening result for CH.The median amount of contrast medium used was 9.0 ml [interquartile range (IQR), 6.0-11.8] in the oil-group and 10.0 ml [IQR, 7.5-14.0] in the water group (P = 0.43). No influence of the amount of contrast on the effect of contrast group on T4 concentrations was found (P-value for interaction, 0.37).Limitations, Reasons For Caution: A relatively small sample size and possible attrition at follow-up are limitations of this study. Although our results suggest that the use of iodinated contrast media for HSG is safe for the offspring, the impact of a decrease in maternal thyroid function on offspring neurodevelopment could not be excluded, as data on maternal thyroid function after HSG and during conception were lacking.Wider Implications Of the Findings: As HSG with oil-based contrast does not affect thyroid function of the offspring, there is no reason to withhold this contrast to infertile women undergoing HSG. Future studies should investigate whether HSG with iodinated contrast influences the periconceptional maternal thyroid function and, consequently, offspring neurodevelopment.Study Funding/competing Interest(s): This study received no funding. The original H2Oil RCT was an investigator-initiated study that was funded by the two academic institutions (Academic Medical Center and VU University Medical Center) of the Amsterdam UMC. The funders had no role in study design, collection, analysis and intrepretation of the data. I.R. reports receiving travel fee from Guerbet. C.B.L. reports speakers fee from Ferring in the past and research grants from Ferring, Merck and Guerbet. K.D. reports receiving travel fee and speakers fee from Guerbet. B.W.M. is supported by a NHMRC Practitioner Fellowship (GNT1082548). B.W.M. reports consultancy for ObsEva, Merck KGaA and Guerbet and travel and research grants from Merck KGaA and Guerbet. V.M. reports receiving travel fee and speakers fee as well as research grants from Guerbet. The other authors do not report conflicts of interest.Trial Registration Number: Netherlands Trial Register NTR 7526 (Neonates born after the H2Oil study), NTR 3270 (original H2Oil study), www.trialregister.nl. [ABSTRACT FROM AUTHOR]- Published
- 2020
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12. Design research on business models in home healthcare
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Simonse, LWL, Zonneland, J, Liu, KQ, Govers, F, Vincent, R, Laban, V, Jensen, MG, van Roest, I, Hulsebosch, M, Hibolling, S, Voorend, M, Jun, C, Lockwood, T, Liu, JK, Wang, S, Song, Q, Siu, N, and Lee, A
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In Home Healthcare, a huge number of telemonitoring pilots have been executed. Positive indications suggest reduction of health problems and support in helping patients to gain control. For healthcare providers, significantreductions in healthcare costs have been estimated. However,” despite this large amount of pilot studies and the positive indications of benefits, there is only minor use of these telemonitoring systems outside research projects”.Gruber ea.(2009) identified a major innovation barrier for the diffusion of telemonitoring solutions to health care providers: “Unclear business models and high costs of change for the health providers”. Traditional businessmodels of the healthcare providers seem not to fit with the telemonitoring solutions. We started a design research study to investigate the business model designs of home healthcare services. We used an inductive researchapproach by in-depth qualitative analysis grounded in telemonitoring pilot studies. We first build our research on the four box framework of business model designs (ea. Johnson ea. 2008, Amit & Zott, 2009). Then we exploredhome healthcare services in the Netherlands and China. In the Netherlands we collected data from different actor perspectives (#32). In Eastern China we collected data from end users (#8) and compared this to an end user groupsin the Netherlands. These findings results in an overview of insights for business models in home health care.
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- 2011
13. What is the fertility-enhancing effect of tubal flushing? A hypothesis article.
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Roest I, Hajiyavand AM, Bongers MY, Mijatovic V, Mol BWJ, Koks CAM, and Dearn KD
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- Contrast Media, Fallopian Tubes, Female, Fertility, Humans, Hysterosalpingography adverse effects, Lubricants, Oils, Receptors, Opioid, Water, Fertility Agents, Infertility, Female etiology, Iodine
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Hysterosalpingographies (HSGs) have formed an essential part of the fertility workup for more than a century. More recently, tubal flushing, especially with oil-based contrast, has been shown to significantly improve the natural conception rates. Critically, the mechanism of this fertility-enhancing effect during tubal flushing is still unclear. This article postulates hypotheses, based on published and own research, on the potential mechanisms and root cause of tubal flushing fertility enhancement. Possible explanations for the increased fertility rates, especially with oil-based contrast, are divided into the biochemical and interfacial effects derived from the contrast properties. The biochemical effects may include the immunological response of the endometrium or peritoneum, the impact on the endometrial opioid receptors or the iodine content. The interfacial effects may include improvement of interfacial factors due to the lubricant effect or dislodgement of mucus debris within the Fallopian tubes. Impact Statement What is already known on this subject? Tubal flushing during hysterosalpingographies (HSGs) increases natural conception rates, and using oil-based over water-based contrast increases that effect even further. However, the underlying mechanism of the observed fertility-enhancing effect is still poorly understood. What do the results of this study add? This article postulates different hypotheses on the potential mechanisms and root cause of the fertility enhancement from tubal flushing. What are the implications of these findings for clinical practice and/or further research? We suggest additional research on the different hypotheses, intending to determine which subfertile women will benefit most from tubal flushing using oil-based contrast and at which stage of their subfertility. Furthermore, we suggest research on administering tubal flushing with oil-based contrast, besides in HSG.
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- 2022
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14. Pain scores during oocyte retrieval for IVF/ICSI: A retrospective cohort study comparing three different analgesia protocols.
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Buisman ETIA, Roest I, van der Steeg JW, Smeenk JMJ, and Koks CAM
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- Aged, Alfentanil, Analgesics, Opioid, Female, Fertilization in Vitro methods, Humans, Pain, Retrospective Studies, Sperm Injections, Intracytoplasmic methods, Analgesia methods, Oocyte Retrieval methods
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Objective: Oocyte retrieval is a painful, but essential element of IVF/ICSI. Evidence for the best method of analgesia is lacking. In the Netherlands, the three most common analgesia protocols entail administration of oral analgesics, intravenous opioids, and intramuscular opioids. The aim of this study was to compare these methods., Methods: A retrospective cohort study was conducted at three clinics. Clinic one provided oral analgesics (1000 mg paracetamol and 500 mg naproxen). The main component of analgesia at clinic two was opioids intravenously (50-100 µg fentanyl), and at clinic three, this was opioids intramuscularly (0.01 mg/kg alfentanil). Intraprocedural pain was registered on an 11-point scale. Univariate analyses were performed to identify factors significantly associated with pain scores. A mixed linear model was used to uncover mean pain scores per clinic., Results: In total, 2,127 oocyte retrievals were included. Pain scores were lower in older women; scores decreased 0.06 points per year (95%-confidence interval (CI): 0.04-0.08). Per extra follicle, scores were 0.05 points higher (95%-CI: 0.03-0.06). Endometriosis resulted in 0.45-point higher scores (95%-CI: 0.01-0.88). Primary subfertility resulted in a 0.36-point increase in scores (95%-CI: 0.15-0.56). Nulliparous women had a 0.41-point higher score than multiparous women (95%-CI: 0.19-0.63). These effects were mostly similar in all clinics. Mean pain scores were 5.6 at clinic number 1 (95%-CI: 5.3-5.8), 5.1 at clinic number 2 (95%-CI: 4.9-5.3), and 3.9 at clinic number 3 (95%-CI: 3.8-4.1)., Conclusion: The lowest pain scores were achieved in the clinic that used intramuscular administration of alfentanil, followed by intravenous fentanyl and, finally, non-sedative oral analgesics. Significant correlations between patient characteristics and pain scores were identified., Competing Interests: Conflict of Interest Declarations of interest: none., (Copyright © 2022. Published by Elsevier Masson SAS.)
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- 2022
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15. Safety of oil-based contrast medium for hysterosalpingography: a systematic review.
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Roest I, Rosielle K, van Welie N, Dreyer K, Bongers M, Mijatovic V, Mol BW, and Koks C
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- Humans, Contrast Media adverse effects, Embolism chemically induced, Hysterosalpingography, Iodized Oil adverse effects, Thyroid Diseases chemically induced
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Recent meta-analyses have shown that a hysterosalpingography (HSG) with oil-based contrast increases pregnancy rates in subfertile women. However, the frequency of complications during or after an HSG with oil-based contrast in subfertile women and/or their offspring is still unclear. This systematic review and meta-analysis, without restrictions on language, publication date or study design, was performed to fill this knowledge gap. The results show that the most frequently reported complication was intravasation of contrast, which occurred in 2.7% with the use of oil-based contrast (31 cohort studies and randomized controlled trials [RCT], 95% CI 1.7-3.8, absolute event rate 664/19,339), compared with 2.0% with the use of water-based contrast (8 cohort studies and RCT, 95% CI 1.2-3.0, absolute event rate 18/1006). In the cohort studies and RCT there were 18 women with an oil embolism (18/19,339 HSG), all without serious lasting consequences. Four cases with serious consequences of an oil embolism were described (retinal oil embolism [n = 1] and cerebral complaints [n = 3]); these reports did not describe the use of adequate fluoroscopy guidance during HSG. In conclusion, the most frequently reported complication after an HSG with oil-based contrast is intravasation occurring in 2.7%. In total four cases with serious consequences of oil embolisms in subfertile women were published., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2021
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16. Reply: Higher reported rates of intravasation of oil-soluble contrast media-there may be a silver lining.
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Roest I, Mijatovic V, Bongers M, Koks C, and Mol BW
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- 2020
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17. Complications after hysterosalpingography with oil- or water-based contrast: results of a nationwide survey.
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Roest I, van Welie N, Mijatovic V, Dreyer K, Bongers M, Koks C, and Mol BW
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Study Question: What is the incidence of complications after hysterosalpingography (HSG) using oil-based contrast versus water-based contrast?, Summary Answer: Among 5165 women undergoing HSG, the most frequently reported complication after HSG with oil- and water-based contrast was intravasation of contrast medium (4.8% versus 1.3%, respectively), which was without further consequences, and pulmonary embolization or death did not occur., What Is Known Already: An HSG with oil-based contrast increases pregnancy rates in women with unexplained infertility. However, there have been some concerns regarding complications, including the risks of intravasation of the contrast medium, oil embolism and infection. Here, we present the incidence of complications after HSG with different types of contrast media used in the Netherlands in the year 2017., Study Design Size Duration: In January 2018, an electronic survey was sent to all 73 clinics in the Netherlands that perform HSG. The survey consisted of 12 questions addressing the number of HSGs performed in 2017, the amount and type of contrast medium used, the occurrence of post-procedural complications and what their clinical consequences were. Non-responding clinics were sent multiple reminders., Participants/materials Setting Methods: We calculated the incidence of the complications and reported on their clinical consequences. Furthermore, we examined the average amount of contrast used as well as the administration of prophylactic antibiotics., Main Results and the Role of Chance: The response rate was 96% (67/70) (during the study, one site closed and was not included while two clinics no longer performed HSGs). In the 67 clinics, 3289 HSGs with oil-based contrast and 1876 HSGs with water-based contrast were performed in 2017. The median amount of contrast used was 8.0 ml (interquartile range (IQR) 7.0-10.0) for oil-based contrast and 10.0 ml for water-based contrast (IQR 10.0-10.0). Antibiotic prophylaxis was administered in 61% (41/67) of the clinics. Intravasation occurred in 4.8% of the HSGs performed with oil-based contrast and in 1.3% of the HSGs with water-based contrast (relative risk (RR), 3.6; CI, 2.4-5.4). Pulmonary embolism or death was not reported. Pelvic inflammatory disease (PID) occurred in 0.3% of the HSGs performed with oil-based contrast versus 0.4% with water-based contrast. PID occurred in 0.3% of the HSGs in clinics using antibiotic prophylaxis and 0.2% in clinics not using antibiotic prophylaxis. Allergic reactions were reported in one HSG performed with oil-based contrast (0.03%) compared with two HSGs performed with water-based contrast (0.1%). Anaphylactic reactions did not occur. The overall complication rate was 5.1% in the clinics that used oil-based contrast versus 1.8% in the clinics that used water-based contrast (RR, 2.8; CI, 1.9-4.0; P -value, <0.0001)., Limitations Reasons for Caution: Half of the clinics did not routinely register complications, and the incidence of the complications in their clinic was based on the recall of the clinician. Estimated complication rates in the clinics with and without systematic registration did not significantly differ. The survey asked about the frequency of intravasation but no classification system is being used in daily practice, which may create differences in reporting. There was no standard screening of post-HSG thyroid function for the mother and the foetus., Wider Implications of the Findings: In this nationwide cohort study, the complication rates after HSG were low. Intravasation occurred more frequently with the use of oil-based contrast compared with water-based contrast but did not lead to any problems or symptoms in any of the women. We therefore conclude that safety concerns should not be a reason to deny the use of oil-based contrast in women with unexplained infertility. The data also support that fluoroscopy appears to be an essential safety measure during HSG., Study Funding/competing Interests: This work was partly funded by Guerbet, France. I.R. reports receiving travel fee for presenting at the Congress of the American Society for Reproductive Medicine 2019 from Guerbet. V.M. reports receiving travel and speaker's fee as well as research grants from Guerbet. K.D. reports receiving travel and speaker's fee from Guerbet. B.W.M. is supported by an National Health and Medical Research Council (NHMRC) Practitioner Fellowship (GNT1082548). B.W.M. reports consultancy for ObsEva, Merck KGaA and Guerbet and travel and research grants from Merck KGaA and Guerbet. The other authors do not report conflicts of interest., Trial Registration Number: N19.056., (© The Author(s) 2020. Published byOxford University Press on behalf of the European Society of Human Reproduction and Embryology.)
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- 2020
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18. Different methods of pain relief for IVF and ICSI oocyte retrieval - A Dutch survey.
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Roest I, Buisman ETIA, van der Steeg JW, and Koks CAM
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Objective: Which analgesia methods are used during oocyte retrieval in the Netherlands?, Studydesign: In April 2017, an online survey containing questions on the analgesia protocol used for IVF/ICSI oocyte retrieval was sent to all clinics in the Netherlands that perform oocyte retrievals., Results: The response rate was 97%. We uncovered the large variety of medication protocols used for pain relief during oocyte retrieval in the Netherlands. Based on the main component of the given analgesia, we distinguished the three most frequently used analgesia protocols: intravenously (i.v.) administered opioids, intramuscularly (i.m) administered opioids, and non-sedative oral analgesics. Aside from analgesia, 61% provided anxiolysis with a benzodiazepine. Nearly half of the clinics registered pain scores. The vital functions were monitored at all clinics administering opioids i.v., but at none of the clinics administering opioids i.m., Conclusions: A wide variety of analgesia protocols are used. The three most frequently used are i.v. administered opioids, i.m. administered opioids, and non-sedative oral analgesics. The variety of analgesia protocols is not desirable in the context of good clinical practice, and considering the risks of combining opioids and benzodiazepines. Monitoring of vital functions was only performed after administration of i.v. medication. A comparison of the pain scores could be a first step in finding the optimal method of analgesia, thereby forming the basis of guidelines for analgesia during oocyte retrieval.
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- 2019
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