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1. Increased detection of 14-3-3 protein in cerebrospinal fluid in Sporadic Creutzfeldt-Jakob Disease during the disease course

Author

Yves Moene, Pierric Giraud, Guy Chazot, Olivier Joyeux, Armand Perret-Liaudet, Roger Later, and Anne-Gaëlle Biacabe

Subjects
Neurological signs, Male, Pathology, medicine.medical_specialty, Time Factors, Tyrosine 3-Monooxygenase, Blotting, Western, Disease, Electroencephalography, Sensitivity and Specificity, Creutzfeldt-Jakob Syndrome, Disease course, Cerebrospinal fluid, Reference Values, mental disorders, medicine, Humans, 14-3-3 protein, CSF albumin, Aged, medicine.diagnostic_test, business.industry, Sporadic Creutzfeldt-Jakob disease, Middle Aged, Prognosis, nervous system diseases, Neurology, 14-3-3 Proteins, Female, Neurology (clinical), business
Abstract

Diagnosis of Creutzfeldt-Jakob Disease (CJD) is based on neurological signs associated with characteristic electroencephalographic activity or detection of 14-3-3 protein in cerebrospinal fluid. However, the time course of 14-3-3 protein release during sporadic CJD is unknown. We report two observations in which the level of the detected 14-3-3 protein increased significantly with time. These preliminary cases suggest that there may be an increased release of 14-3-3 protein during the course of CJD as already proven for iatrogenic CJD.

Published
2002

2. Microdialysis study of amino acid neurotransmitters in the spinal dorsal horn of patients undergoing microsurgical dorsal root entry zone lesioning. Technical note

Author

Laurent Laganier, Marc Sindou, Armand Perret-Liaudet, Hussein Naous, Bernard Renaud, Chantal Ghaemmaghami, Roger Later, Patrick Mertens, Lionel Bert, and Marc Guénot

Subjects
Adult, Male, Microdialysis, Microsurgery, Nerve root, Adolescent, Central nervous system, Inhibitory postsynaptic potential, chemistry.chemical_compound, Extracellular fluid, medicine, Humans, Amino Acids, Neurotransmitter, Neurotransmitter Agents, business.industry, Osmolar Concentration, Glutamate receptor, General Medicine, Middle Aged, Spinal cord, medicine.anatomical_structure, chemistry, Spinal Cord, Anesthesia, Female, business, Spinal Nerve Roots
Abstract

✓ The aim of this study was to develop, for the first time in the human spinal dorsal horn (DH), an in vivo method for the study of amino acids (AAs). A microdialysis technique was used to sample AAs in the extracellular fluid of the DH apex in eight patients in whom surgery in the dorsal root entry zone (DREZ) was performed. Before making microsurgical lesions, specific concentric-type microdialysis probes were implanted over a 60-minute period in the DREZ and directed to the DH apex (10 implantations). The AA concentrations in the dialysates were determined using high-performance liquid chromatography with fluorescence detection. The concentrations of excitatory AAs (glutamate and aspartate) and inhibitory AAs (γ-aminobutyric acid and glycine) decreased and were stabilized by 45 minutes after probe implantation, whereas the levels of nonneurotransmitter AAs (alanine and threonine) were not stabilized at 60 minutes. The ability of the probe to track the changes of extracellular AAs was demonstrated. Neither intra- nor postoperative microdialysis-related complications were observed (with a follow up of 18 months). The present study demonstrates that microdialysis can be performed safely in the human DH during DREZ lesioning. Despite technical and analytical limitations related to the intraoperative conditions, this technique offers new possibilities for clinical research on neurotransmitters involved in some relevant pathological states, especially in chronic pain and spasticity.

Published
2001

3. Contents Vol. 48, 2002

Author

Yves Moene, J. Fujitake, Alberto Olaizola, Paolo Livrea, Jose Ramon Fernandez, Noritoshi Arai, Marco Furlanut, Kon-Ping Lin, Ryusaku Hashimoto, Y. Funabiki, Carmen García-Sánchez, Roger Later, Giovanni Defazio, Joan Martí-Fàbregas, K. Nishimura, B. Sánchez, Bing-Wen Soong, D. García, Tsung-Yun Liu, Manuel Barón-Rubio, Chen-Jee Hong, Anneke Zorgdrager, Jorge Ortiz De Urbina, C. Valencia, Miguel Montejo, Andres Valdivieso, Carmen Varas, Guy Chazot, Milagros Testillano, Y. Tatsuoka, Massimo Baraldo, Armand Perret-Liaudet, Shinya Sakai, Jacques De Keyser, R. García Lozano, Lídice Vidal, Pierric Giraud, Janette Hoenicka, Olivier Joyeux, H. Fujii, Chien-Nan Lin, K. Hayakawa, R. Alberca, Juan Carlos Martínez-Castrillo, Josep-Lluis Martí-Vilalta, Maria Stella Aniello, Koldo Aguirrebengoa, Kazumi Hirayama, Jesús Pujol, P. Benetello, Shih-Jen Tsai, Agnese Tonon, Anne-Gaëlle Biacabe, Atsushi Yamadori, Mario Furlanut, E. Montes, Shuji Kishida, Syoichi Iwasaki, María de Toledo-Heras, E. Gil-Néciga, L. Vitek, Hsiu-Chih Liu, K. Takasu, Francesco Roselli, B. Tettenborn, Marina de Tommaso, Félix Javier Jiménez-Jiménez, Keiko Ohta, Toshikatsu Fujii, Kouichiro Okamoto, F. Boza, Asako Yoritaka, and José Martín Zurdo

Subjects
Neurology, Neurology (clinical)
Published
2002
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4. Subject Index Vol. 48, 2002

Author

Syoichi Iwasaki, Paolo Livrea, Yves Moene, Alberto Olaizola, Asako Yoritaka, José Martín Zurdo, P. Benetello, Pierric Giraud, Chien-Nan Lin, Keiko Ohta, Janette Hoenicka, Carmen García-Sánchez, Noritoshi Arai, M. Testillano, Jorge Ortiz de Urbina, Anneke Zorgdrager, Marco Furlanut, Giovanni Defazio, Miguel Montejo, Jose Ramon Fernandez, B. Tettenborn, Joan Martí-Fàbregas, Marina de Tommaso, Kon-Ping Lin, F. Boza, D. García, Chen-Jee Hong, Armand Perret-Liaudet, Félix Javier Jiménez-Jiménez, R. García Lozano, Carmen Varas, Hsiu-Chih Liu, H. Fujii, Lídice Vidal, Tsung-Yun Liu, Guy Chazot, C. Valencia, Roger Later, K. Hayakawa, Y. Tatsuoka, Francesco Roselli, Anne-Gaëlle Biacabe, Koldo Aguirrebengoa, L. Vitek, R. Alberca, Juan Carlos Martínez-Castrillo, Shinya Sakai, Mario Furlanut, Y. Funabiki, K. Nishimura, Josep-Lluis Martí-Vilalta, Jacques De Keyser, Olivier Joyeux, Massimo Baraldo, Atsushi Yamadori, Ryusaku Hashimoto, B. Sánchez, Maria Stella Aniello, Shih-Jen Tsai, Bing-Wen Soong, Andrés Valdivieso, María de Toledo-Heras, Kazumi Hirayama, E. Gil-Néciga, Jesús Pujol, Agnese Tonon, Manuel Barón-Rubio, E. Montes, Shuji Kishida, J. Fujitake, K. Takasu, Toshikatsu Fujii, and Kouichiro Okamoto

Subjects
Cognitive science, Index (economics), Neurology, Subject (documents), Neurology (clinical), Psychology, Cognitive psychology
Published
2002
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