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1. The role of stroke-induced immunosuppression as a predictor of functional outcome in the neurorehabilitation setting

Author

Vaghi, Gloria, Morotti, Andrea, Piella, Elisa Maria, Avenali, Micol, Martinelli, Daniele, Cristina, Silvano, Allena, Marta, Grillo, Valentina, Corrado, Michele, Bighiani, Federico, Cammarota, Francescantonio, Antoniazzi, Alessandro, Ferrari, Federica, Mazzacane, Federico, Cavallini, Anna, Pichiecchio, Anna, Rognone, Elisa, Martinis, Luca, Correale, Luca, Castiglia, Stefano Filippo, Trabassi, Dante, Serrao, Mariano, Tassorelli, Cristina, and De Icco, Roberto

Published
2024
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2. Clusters in randomly-coloured spatial networks

Author

Rognone, Silvia and Nicosia, Vincenzo

Subjects
Physics - Physics and Society, Condensed Matter - Statistical Mechanics, Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract

The behaviour and functioning of a variety of complex physical and biological systems depend on the spatial organisation of their constituent units, and on the presence and formation of clusters of functionally similar or related individuals. Here we study the properties of clusters in spatially-embedded networks where nodes are coloured according to a given colouring process. This characterisation will allow us to use spatial networks with uniformly-coloured nodes as a null-model against which the importance, relevance, and significance of clusters of related units in a given real-world system can be assessed. We show that even a uniform and uncorrelated random colouring process can generate coloured clusters of substantial size and interesting shapes, which can be distinguished by using some simple dynamical measures, like the average time needed for a random walk to escape from the cluster. We provide a mean-field approach to study the properties of those clusters in large two-dimensional lattices, and we show that the analytical treatment agrees very well with the numerical results., Comment: 21 pages, 11 figures

Published
2023

4. Impact of the inversion time on regional brain perfusion estimation with clinical arterial spin labeling protocols.

Author

Sanvito, Francesco, Palesi, Fulvia, Rognone, Elisa, Barzaghi, Leonardo, Pasca, Ludovica, Germani, Giancarlo, De Giorgis, Valentina, Borgatti, Renato, Gandini Wheeler-Kingshott, Claudia, and Pichiecchio, Anna

Subjects
Arterial spin labeling, Brain perfusion, Cerebral blood flow, Inversion time, Post-labeling delay, Adolescent, Arteries, Brain, Cerebrovascular Circulation, Child, Humans, Magnetic Resonance Imaging, Perfusion, Spin Labels
Abstract

OBJECTIVE: Evaluating the impact of the Inversion Time (TI) on regional perfusion estimation in a pediatric cohort using Arterial Spin Labeling (ASL). MATERIALS AND METHODS: Pulsed ASL (PASL) was acquired at 3 T both at TI 1500 ms and 2020 ms from twelve MRI-negative patients (age range 9-17 years). A volume of interest (VOIs) and a voxel-wise approach were employed to evaluate subject-specific TI-dependent Cerebral Blood Flow (CBF) differences, and grey matter CBF Z-score differences. A visual evaluation was also performed. RESULTS: CBF was higher for TI 1500 ms in the proximal territories of the arteries (PTAs) (e.g. insular cortex and basal ganglia - P

Published
2022

5. Real-life efficacy and safety of cemiplimab in advanced cervical cancer from a nominal use program in Italy: The MITO 44 study

Author

Tuninetti, Valentina, Virano, Elisa, Salutari, Vanda, Ricotti, Andrea, Pisano, Carmela, Ducceschi, Monika, Turitto, Giacinto, Scandurra, Giuseppa, Petrella, Maria Cristina, Forestieri, Valeria, Rizzetto, Monica, Mammoliti, Serafina, Artioli, Grazia, Cioffi, Raffaella, Borsotti, Lucia, Bellero, Marco, Rognone, Chiara, Carbone, Vittoria, Ferrandina, Gabriella, Mantiero, Mara, Azzolina, Carmen, Geninatti, Eleonora, Pignata, Sandro, and Valabrega, Giorgio

Published
2024
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7. Optimising the mitigation of epidemic spreading through targeted adoption of contact tracing apps

Author

Bassolas, Aleix, Santoro, Andrea, Sousa, Sandro, Rognone, Silvia, and Nicosia, Vincenzo

Subjects
Physics - Physics and Society, Computer Science - Social and Information Networks, Physics - Biological Physics
Abstract

The ongoing COVID-19 pandemic is the first epidemic in human history in which digital contact-tracing has been deployed at a global scale. Tracking and quarantining all the contacts of individuals who test positive to a virus can help slowing-down an epidemic, but the impact of contact-tracing is severely limited by the generally low adoption of contact-tracing apps in the population. We derive here an analytical expression for the effectiveness of contact-tracing app installation strategies in a SIR model on a given contact graph. We propose a decentralised heuristic to improve the effectiveness of contact tracing under fixed adoption rates, which targets a set of individuals to install contact-tracing apps, and can be easily implemented. Simulations on a large number of real-world contact networks confirm that this heuristic represents a feasible alternative to the current state of the art., Comment: 10 pages, 5 figures, + 12 SI pages, 9 suppl. figs, 1 suppl. table

Published
2021

9. The asymmetric effects of climate risk on higher-moment connectedness among carbon, energy and metals markets

Author

Yuqin Zhou, Shan Wu, Zhenhua Liu, and Lavinia Rognone

Subjects
Science
Abstract

Abstract Climate change affects price fluctuations in the carbon, energy and metals markets through physical and transition risks. Climate physical risk is mainly caused by extreme weather, natural disasters and other events caused by climate change, whereas climate transition risk mainly results from the gradual switchover to a low-carbon economy. Given that the connectedness between financial markets may be affected by various factors such as extreme events and economic transformation, understanding the different roles of climate physical risk and transition risk on the higher-moment connectedness across markets has important implications for investors to construct portfolios and regulators to establish regulation system. Here, using the GJRSK model, time-frequency connectedness framework and quantile-on-quantile method, we show asymmetric effects of climate risk on connectedness among carbon, energy and metals markets, with higher impacts of climate physical risk on upward risk spillovers, and greater effects of climate transition risk on the downside risk of kurtosis connectedness.

Published
2023
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10. Management of Trastuzumab Deruxtecan-related nausea and vomiting in real-world practice

Author

Giulia Notini, Matteo Maria Naldini, Lorenzo Sica, Giulia Viale, Alessia Rognone, Stefania Zambelli, Patrizia Zucchinelli, Marta Piras, Carlo Bosi, Marco Mariani, Daniela Aldrighetti, Giampaolo Bianchini, and Luca Licata

Subjects
nausea, vomiting, antiemetic prophylaxis, Trastuzumab Deruxtecan, breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundNausea and vomiting are common side effects of Trastuzumab Deruxtecan (T-DXd), but guidelines for optimal management were not initially available. This retrospective single-center study aimed at evaluating the efficacy of two antiemetic regimens in patients receiving T-DXd.MethodsData from metastatic breast cancer patients receiving T-DXd were collected. Two groups were defined: patients treated with 5-HT3 receptor antagonists (RA) ± dexamethasone (5-HT3-group) and patients treated with a fixed oral combination of netupitant (NK1RA) and palonosetron ± dexamethasone (NK1 group). Physicians preferentially offered the NK1 regimen to patients at higher risk of nausea and vomiting based on internal recommendations. Only nausea and vomiting during cycles 1 and 2 were considered. Comparisons of nausea and vomiting by the antiemetic prophylaxis group were assessed using chi-square.ResultsA total of 53 patients were included in the analysis. At cycle 1, 72% and 28% of patients received the 5-HT3 and NK1 prophylaxis, respectively. Overall, 58% reported nausea, with no differences between groups (58% vs. 60%; p = 0.832), but with a trend for lower grade in the NK1 group (33.3% G1; 26.7% G2) compared to the 5-HT3 group (23.7% G1; 31.6% G2; 2.6% G3). Vomiting was reported by 21% and 0% of patients in the 5-HT3 and the NK1 group, respectively (p = 0.054). Among the 15 patients in the 5-HT3 group with nausea at cycle 1 who escalated to NK1 at cycle 2, nausea decreased from 100% to 53% (p = 0.022) and vomiting decreased from 47% to 13% (p = 0.046).ConclusionsThe NK1 regimen improved vomiting control at cycle 1 and, when introduced at cycle 2, significantly improved both nausea and vomiting. The biased NK1 selection for higher-risk patients may have dampened the differences between groups at cycle 1. These findings support enhanced control of T-DXd-related nausea and vomiting with NK1RA.

Published
2024
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11. Oncotype DX results increase concordance in adjuvant chemotherapy recommendations for early-stage breast cancer

Author

Luca Licata, Giulia Viale, Mario Giuliano, Giuseppe Curigliano, Mariana Chavez-MacGregor, Julia Foldi, Oluchi Oke, Joseph Collins, Lucia Del Mastro, Fabio Puglisi, Filippo Montemurro, Claudio Vernieri, Lorenzo Gerratana, Sara Giordano, Alessia Rognone, Lorenzo Sica, Oreste Davide Gentilini, Stefano Cascinu, Lajos Pusztai, Antonio Giordano, Carmen Criscitiello, and Giampaolo Bianchini

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Adjuvant chemotherapy recommendations for ER+/HER2− early-stage breast cancers (eBC) involve integrating prognostic and predictive information which rely on physician judgment; this can lead to discordant recommendations. In this study we aim to evaluate whether Oncotype DX improves confidence and agreement among oncologists in adjuvant chemotherapy recommendations. We randomly select 30 patients with ER+/HER2− eBC and recurrence score (RS) available from an institutional database. We ask 16 breast oncologists with varying years of clinical practice in Italy and the US to provide recommendation for the addition of chemotherapy to endocrine therapy and their degree of confidence in the recommendation twice; first, based on clinicopathologic features only (pre-RS), and then with RS result (post-RS). Pre-RS, the average rate of chemotherapy recommendation is 50.8% and is higher among junior (62% vs 44%; p

Published
2023
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13. Essays in empirical finance : news sentiment in cryptocurrency, the value of noise timing, and the pricing of climate change risks

Author

Rognone, Lavinia, Hyde, Stuart, and Zhang, Sarah

Subjects
Economic value, Portfolio allocation, Climate risk, Physical risk, Pricing of climate risk, Textual analysis, Transition risk, Kalman filter, Noise risk, Noise, Foreign Exchange, News sentiment, Bitcoin, Cryptocurrency, Digital currencies, Noise trading
Abstract

This thesis improves the understanding of cryptocurrencies as financial assets by examining the Bitcoin reaction to high-frequency news compared to Forex, explores the role of news within financial markets, quantifies the economic value of a novel investment strategy which times financial noise able to manage price noise-risk, and assesses the extent to which climate change physical and transition risks are incorporated into asset prices. The thesis consists of three essays. The first essay "News sentiment in the cryptocurrency market: An empirical comparison with Forex" considers high frequency intra-day data to investigate the influence of unscheduled currency and Bitcoin news on the returns, volume and volatility of the cryptocurrency Bitcoin and traditional currencies over the period from January 2012 to November 2018. Results show that Bitcoin behaves differently to traditional currencies. Fiat currencies typically experience a decrease in returns after negative news arrivals and an increase in returns following positive news whereas Bitcoin reacts positively to both positive and negative news. This suggests investor enthusiasm for Bitcoin irrespective of the sentiment of the news. This phenomenon exacerbates during bubble periods. Conversely, cryptocurrency cyber-attack news and fraud news dampen this effect, decreasing Bitcoin returns and volatility. The second essay "The economic value of financial noise timing" proposes a dynamic noise-timing strategy which exploits the temporary dependence in noise traders' beliefs. Decomposing prices of the portfolio assets (stocks, bonds, gold, and cryptocurrencies) into permanent and noise components, we assess the economic value of a dynamic investment strategy which times the noise component. Our results show that risk averse and short horizon investors would be willing to pay a positive annual performance fee of between 314 and 940 basis points to switch from an ex-ante static investment strategy to a noise timing strategy. Our findings are robust to comparisons with other benchmark strategies, such as the volatility timing, and different periods of heightened volatility, including the Covid-19 period. The third essay "Transition versus physical climate risk pricing in euro area financial markets: A text-based approach" prices climate change risks in equity markets within a Fama-French five factor model. We build two novel vocabularies on physical and transition climate risks, and we construct a Physical Risk Index and a Transition Risk Index comparing them to a corpus of news over the period 2015-2019 using the cosine-similarity approach. Climate news are found to carry relevant information especially for brown firms, with transition risk appearing to be more concerning for investors. Returns of low environmental and ESG scores firms negatively relate to both shocks to physical and transition risk, whereas returns of high Greenhouse Gas emissions levels and intensity firms further decline with transition risk news. While investors appear to penalise high climate risk exposure, there is no evidence of an increase in returns of less exposed firms.

Published
2021

18. Characterization of HER2-low breast cancer in young women with germline BRCA1/2 pathogenetic variants: Results of a large international retrospective cohort study

Author

Schettini, F, Blondeaux, E, Molinelli, C, Bas, R, Kim, H, Di Meglio, A, Bernstein Molho, R, Linn, S, Pogoda, K, Carrasco, E, Punie, K, Agostinetto, E, Lopetegui-Lia, N, Phillips, K, Toss, A, Rousset-Jablonski, C, Acheritogaray, M, Ferrari, A, Paluch-Shimon, S, Fruscio, R, Cui, W, Wong, S, Vernieri, C, Dieci, M, Matikas, A, Rozenblit, M, Villarreal-Garza, C, De Marchis, L, Puglisi, F, Vasconcelos de Matos, L, Marino, M, Teixeira, L, Graffeo, R, Rognone, A, Chirco, A, Antone, N, Abdou, Y, Marhold, M, Bozovic-Spasojevic, I, Cortes Salgado, A, Carmisciano, L, Bruzzone, M, Curigliano, G, Prat, A, Lambertini, M, Schettini F., Blondeaux E., Molinelli C., Bas R., Kim H. J., Di Meglio A., Bernstein Molho R., Linn S. C., Pogoda K., Carrasco E., Punie K., Agostinetto E., Lopetegui-Lia N., Phillips K. -A., Toss A., Rousset-Jablonski C., Acheritogaray M., Ferrari A., Paluch-Shimon S., Fruscio R., Cui W., Wong S. M., Vernieri C., Dieci M. V., Matikas A., Rozenblit M., Villarreal-Garza C., De Marchis L., Puglisi F., Vasconcelos de Matos L., Marino M., Teixeira L., Graffeo R., Rognone A., Chirco A., Antone N., Abdou Y., Marhold M., Bozovic-Spasojevic I., Cortes Salgado A., Carmisciano L., Bruzzone M., Curigliano G., Prat A., Lambertini M., Schettini, F, Blondeaux, E, Molinelli, C, Bas, R, Kim, H, Di Meglio, A, Bernstein Molho, R, Linn, S, Pogoda, K, Carrasco, E, Punie, K, Agostinetto, E, Lopetegui-Lia, N, Phillips, K, Toss, A, Rousset-Jablonski, C, Acheritogaray, M, Ferrari, A, Paluch-Shimon, S, Fruscio, R, Cui, W, Wong, S, Vernieri, C, Dieci, M, Matikas, A, Rozenblit, M, Villarreal-Garza, C, De Marchis, L, Puglisi, F, Vasconcelos de Matos, L, Marino, M, Teixeira, L, Graffeo, R, Rognone, A, Chirco, A, Antone, N, Abdou, Y, Marhold, M, Bozovic-Spasojevic, I, Cortes Salgado, A, Carmisciano, L, Bruzzone, M, Curigliano, G, Prat, A, Lambertini, M, Schettini F., Blondeaux E., Molinelli C., Bas R., Kim H. J., Di Meglio A., Bernstein Molho R., Linn S. C., Pogoda K., Carrasco E., Punie K., Agostinetto E., Lopetegui-Lia N., Phillips K. -A., Toss A., Rousset-Jablonski C., Acheritogaray M., Ferrari A., Paluch-Shimon S., Fruscio R., Cui W., Wong S. M., Vernieri C., Dieci M. V., Matikas A., Rozenblit M., Villarreal-Garza C., De Marchis L., Puglisi F., Vasconcelos de Matos L., Marino M., Teixeira L., Graffeo R., Rognone A., Chirco A., Antone N., Abdou Y., Marhold M., Bozovic-Spasojevic I., Cortes Salgado A., Carmisciano L., Bruzzone M., Curigliano G., Prat A., and Lambertini M.

Abstract

Background: Breast cancer (BC) in women aged ≤40 years carrying germline pathogenetic variants (PVs) in BRCA1/2 genes is infrequent but often associated with aggressive features. Human epidermal growth factor receptor 2 (HER2)-low-expressing BC has recently emerged as a novel therapeutic target but has not been characterized in this rare patient subset. Methods: Women aged ≤40 years with newly diagnosed early-stage HER2-negative BC (HER2-0 and HER2-low) and germline BRCA1/2 PVs from 78 health care centers worldwide were retrospectively included. Chi-square test and Student t-test were used to describe variable distribution between HER2-0 and HER2-low. Associations with HER2-low status were assessed with logistic regression. Kaplan–Meier method and Cox regression analysis were used to assess disease-free survival (DFS) and overall survival. Statistical significance was considered for p ≤.05. Results: Of 3547 included patients, 32.3% had HER2-low BC, representing 46.3% of hormone receptor–positive and 21.3% of triple-negative (TN) tumors. HER2-low vs. HER2-0 BC were more often of grade 1/2 (p <.001), hormone receptor–positive (p <.001), and node-positive (p =.003). BRCA2 PVs were more often associated with HER2-low than BRCA1 PVs (p <.001). HER2-low versus HER2-0 showed better DFS (hazard ratio [HR], 0.86; 95% CI, 0.76–0.97) in the overall population and more favorable DFS (HR, 0.78; 95% CI, 0.64–0.95) and overall survival (HR, 0.65; 95% CI, 0.46–0.93) in the TN subgroup. Luminal A–like tumors in HER2-low (p =.014) and TN and luminal A-like in HER2-0 (p =.019) showed the worst DFS. Conclusions: In young patients with HER2-negative BC and germline BRCA1/2 PVs, HER2-low disease was less frequent than expected and more frequently linked to BRCA2 PVs and associated with luminal-like disease. HER2-low status was associated with a modestly improved prognosis.

Published
2024

19. Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study.

Author

Pasca, Ludovica, Arrigoni, Filippo, Romaniello, Romina, Severino, Maria Savina, Politano, Davide, D'Abrusco, Fulvio, Garau, Jessica, De Giorgis, Valentina, Carpani, Adriana, Signorini, Sabrina, Orcesi, Simona, D'Arco, Felice, Alfei, Enrico, Cattaneo, Elisa, Rognone, Elisa, Uccella, Sara, Divizia, Maria Teresa, Infantino, Paolo, Valente, Enza Maria, and Borgatti, Renato

Published
2025
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21. Quantum entanglement and the Bell Matrix

Author

Lai, Anna Chiara, Pedicini, Marco, and Rognone, Silvia

Subjects
Quantum Physics, 81P68, 81P40
Abstract

We present a class of maximally entangled states generated by a high-dimensional generalisation of the \textsc{cnot} gate. The advantage of our approach is the simple algebraic structure of both entangling operator and resulting entangled states. In order to show that the method can be applied to any dimension, we introduce new sufficient conditions for global and maximal entanglement with respect to Meyer and Wallach's measure., Comment: 11 pages, 3 figures

Published
2015

22. Transition versus physical climate risk pricing in European financial markets: a text-based approach.

Author

Bua, Giovanna, Kapp, Daniel, Ramella, Federico, and Rognone, Lavinia

Subjects
FINANCIAL markets, ECONOMIC impact, RISK premiums, ENVIRONMENTAL, social, & governance factors, INVESTORS
Abstract

Under its climate regulation, the EU is expected to become the first continent with a net-zero emissions balance. We study the pricing of climate risks, physical and transition, within European markets. Using text-analysis, we construct two novel (daily) physical and transition risk indicators for the period 2005–2021 and two global climate risk vocabularies. Applying our climate risk indices to an asset pricing test framework, we document the emergence of economically significant transition and physical risk premia post-2015. From a firm-level analysis, using firms' GHG emissions, GHG emissions intensity, environmental, and ESG scores, we find that rises in transition (physical) risk are typically associated with an increase (decrease) in the return of green (brown) stocks. Firm-level information is used by investors to proxy firms' climate-risks exposure, especially for transition risk since 2015, whereas the sectoral classification appears to proxy firms' exposures to physical risk. From a country-level analysis emerges an intensified connection between European stock markets and climate risks post-2015, yet with some heterogeneity. Our results have important economic implications and show that investors demand compensation for their exposure to both climate risk types. Our novel climate risk vocabularies and indicators find several applications in identifying, measuring, and studying climate risks. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Treatment Strategies for Advanced Endometrial Cancer According to Molecular Classification.

Author

Tuninetti, Valentina, Farolfi, Alberto, Rognone, Chiara, Montanari, Daniela, De Giorgi, Ugo, and Valabrega, Giorgio

Subjects
ENDOMETRIAL cancer, PROTEIN-tyrosine kinase inhibitors, COMBINATION drug therapy, DRUG target, HISTORY of biology, CISPLATIN
Abstract

The management of advanced endometrial cancer (EC) has changed in the last few years due to the introduction of a new molecular classification and the approval of immunotherapy. For a long time, carboplatin plus paclitaxel was considered the standard treatment for first-line advanced EC, since the approval of the combination of chemotherapy plus immunotherapy. For patients with recurrent EC, with previous platinum-based chemotherapy, single-agent immunotherapy or in combination with tyrosine-kinase inhibitor (TKI) has been approved according to mismatch repair status. Ongoing trials are exploring the possibility of a chemo-free future for mismatch repair-deficient (dMMR) EC and new molecular targets are under investigation. The treatment paradigm for advanced EC has shifted from standard chemotherapy for all to a more personalized approach. The aim of this review is to provide an updated therapeutic landscape for the management of patients with advanced/metastatic EC according to their disease history and molecular biology. [ABSTRACT FROM AUTHOR]

Published
2024
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24. "Relapsing–Remitting" Ataxia and Unexpected Brain Imaging in a Child with HIBCH Deficiency.

Author

Gana, Simone, Rossetto, Gloria, Garau, Jessica, Vacchini, Valeria, Ferraro, Francesca, Rognone, Elisa, Pichiecchio, Anna, Gasperini, Serena, Valente, Enza Maria, and Orcesi, Simona

Subjects
CEREBRAL sulci, GENETIC variation, CORPUS callosum, DISABILITIES, EXCEPTIONAL children, FAILURE to thrive syndrome
Abstract

The article discusses a case study of a child with HIBCH deficiency, a rare disorder affecting valine catabolism. The child exhibited atypical symptoms, including delayed motor development and mild ataxia, with unexpected brain imaging findings. Genetic testing revealed novel variants in the HIBCH gene, leading to a unique form of "relapsing-remitting" ataxia triggered by febrile infections. The study highlights the importance of considering HIBCH deficiency in patients with diverse presentations and emphasizes the need for early recognition and intervention for this potentially treatable disease. [Extracted from the article]

Published
2024
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25. Commodity Futures Market Conditions and Climate Policy Risk: Evidence From Energy and Metals Markets.

Author

Dogah, Kingsley E., Wu, Yingying, and Rognone, Lavinia

Subjects
BULL markets, FUTURES market, BEAR markets, COMMODITY futures, HEDGING (Finance)
Abstract

This study investigates the impact of climate policy uncertainty (CPU) on energy and metal commodity futures markets by employing quantile regression, which accounts for various (bearish, normal, and bullish) markets. Our results reveal that the impact of CPU shocks is heterogeneous and market condition‐specific. Particularly, CPU exerts a significantly negative effect on all commodities, except natural gas, in a bearish market. Under a normal market, the impact of CPU on energy returns varies across commodities whereas for a bullish market, the CPU effect is mixed. The results also reveal natural gas to be a good hedge instrument for climate policy risk. We further conducted channel analysis using the theory of storage and hedging pressure hypothesis. The key finding reveals inventory level as the transmission channel of climate policy risk. Our findings have implications for the inventory management strategies of producers and suggest that regulators should consider market‐based policies in their decarbonization efforts. [ABSTRACT FROM AUTHOR]

Published
2024
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26. PONDx: real-life utilization and decision impact of the 21-gene assay on clinical practice in Italy

Author

Francesco Cognetti, Riccardo Masetti, Alessandra Fabi, Giulia Bianchi, Donatella Santini, Alessia Rognone, Giovanna Catania, Domenico Angelucci, Giuseppe Naso, Mario Giuliano, Lucia Vassalli, Patrizia Vici, Giovanni Scognamiglio, Daniele Generali, Alberto Zambelli, Marco Colleoni, Corrado Tinterri, Francesco Scanzi, Leonardo Vigna, Paola Scavina, Teresa Gamucci, Emilia Marrazzo, Angelo Fedele Scinto, Rossana Berardi, Maria Agnese Fabbri, Graziella Pinotti, Daniela Franco, Daniela Andreina Terribile, Giuseppe Tonini, Daniela Cianniello, and Sandro Barni

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Clinicopathological prognostic features have limited value to identify with precision newly diagnosed patients with hormone receptor (HR)-positive, HER2-negative breast cancer (BC), who would benefit from chemotherapy (CT) in addition to adjuvant hormonal therapy (HT). The 21-gene Oncotype DX Breast Recurrence Score® (RS) assay has been demonstrated to predict CT benefit, hence supporting personalized decisions on adjuvant CT. The multicenter, prospective, observational study PONDx investigated the real-life use of RS® results in Italy and its impact on treatment decisions. Physicians’ treatment recommendations (HT ± CT) were documented before and after availability of RS results, and changes in recommendations were determined. In the HR+ HER2− early BC population studied (N = 1738), physicians recommended CT + HT in 49% of patients pre-RS. RS-guided treatment decisions resulted in 36% reduction of CT recommendations. PONDx confirms that RS results provide clinically relevant information for CT recommendation in early-stage BC, resulting in a reduction of more than a third of CT use.

Published
2021
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27. Nonstandard Errors

Author

MENKVELD, ALBERT J., primary, DREBER, ANNA, additional, HOLZMEISTER, FELIX, additional, HUBER, JUERGEN, additional, JOHANNESSON, MAGNUS, additional, KIRCHLER, MICHAEL, additional, NEUSÜß, SEBASTIAN, additional, RAZEN, MICHAEL, additional, WEITZEL, UTZ, additional, ABAD‐DÍAZ, DAVID, additional, ABUDY, MENACHEM (MENI), additional, ADRIAN, TOBIAS, additional, AIT‐SAHALIA, YACINE, additional, AKMANSOY, OLIVIER, additional, ALCOCK, JAMIE T., additional, ALEXEEV, VITALI, additional, ALOOSH, ARASH, additional, AMATO, LIVIA, additional, AMAYA, DIEGO, additional, ANGEL, JAMES J., additional, AVETIKIAN, ALEJANDRO T., additional, BACH, AMADEUS, additional, BAIDOO, EDWIN, additional, BAKALLI, GAETAN, additional, BAO, LI, additional, BARBON, ANDREA, additional, BASHCHENKO, OKSANA, additional, BINDRA, PARAMPREET C., additional, BJØNNES, GEIR H., additional, BLACK, JEFFREY R., additional, BLACK, BERNARD S., additional, BOGOEV, DIMITAR, additional, CORREA, SANTIAGO BOHORQUEZ, additional, BONDARENKO, OLEG, additional, BOS, CHARLES S., additional, BOSCH‐ROSA, CIRIL, additional, BOURI, ELIE, additional, BROWNLEES, CHRISTIAN, additional, CALAMIA, ANNA, additional, CAO, VIET NGA, additional, CAPELLE‐BLANCARD, GUNTHER, additional, ROMERO, LAURA M. CAPERA, additional, CAPORIN, MASSIMILIANO, additional, CARRION, ALLEN, additional, CASKURLU, TOLGA, additional, CHAKRABARTY, BIDISHA, additional, CHEN, JIAN, additional, CHERNOV, MIKHAIL, additional, CHEUNG, WILLIAM, additional, CHINCARINI, LUDWIG B., additional, CHORDIA, TARUN, additional, CHOW, SHEUNG‐CHI, additional, CLAPHAM, BENJAMIN, additional, COLLIARD, JEAN‐EDOUARD, additional, COMERTON‐FORDE, CAROLE, additional, CURRAN, EDWARD, additional, DAO, THONG, additional, DARE, WALE, additional, DAVIES, RYAN J., additional, BLASIS, RICCARDO DE, additional, NARD, GIANLUCA F. DE, additional, DECLERCK, FANY, additional, DEEV, OLEG, additional, DEGRYSE, HANS, additional, DEKU, SOLOMON Y., additional, DESAGRE, CHRISTOPHE, additional, DIJK, MATHIJS A. VAN, additional, DIM, CHUKWUMA, additional, DIMPFL, THOMAS, additional, DONG, YUN JIANG, additional, DRUMMOND, PHILIP A., additional, DUDDA, TOM, additional, DUEVSKI, TEODOR, additional, DUMITRESCU, ARIADNA, additional, DYAKOV, TEODOR, additional, DYHRBERG, ANNE HAUBO, additional, DZIELIŃSKI, MICHAŁ, additional, EKSI, ASLI, additional, KALAK, IZIDIN EL, additional, ELLEN, SASKIA TER, additional, EUGSTER, NICOLAS, additional, EVANS, MARTIN D. D., additional, FARRELL, MICHAEL, additional, FELEZ‐VINAS, ESTER, additional, FERRARA, GERARDO, additional, FERROUHI, EL MEHDI, additional, FLORI, ANDREA, additional, FLUHARTY‐JAIDEE, JONATHAN T., additional, FOLEY, SEAN D. V., additional, FONG, KINGSLEY Y. 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Y. ERIC C., additional, LAMBERT, MARIE, additional, LANGLOIS, HUGUES, additional, LAUSEN, JENS, additional, LAUTER, TOBIAS, additional, LEIPPOLD, MARKUS, additional, LEVIN, VLADIMIR, additional, LI, YIJIE, additional, LI, HUI, additional, LIEW, CHEE YOONG, additional, LINDNER, THOMAS, additional, LINTON, OLIVER, additional, LIU, JIACHENG, additional, LIU, ANQI, additional, LLORENTE, GUILLERMO, additional, LOF, MATTHIJS, additional, LOHR, ARIEL, additional, LONGSTAFF, FRANCIS, additional, LOPEZ‐LIRA, ALEJANDRO, additional, MANKAD, SHAWN, additional, MANO, NICOLA, additional, MARCHAL, ALEXIS, additional, MARTINEAU, CHARLES, additional, MAZZOLA, FRANCESCO, additional, MELOSO, DEBRAH, additional, MI, MICHAEL G., additional, MIHET, ROXANA, additional, MOHAN, VIJAY, additional, MOINAS, SOPHIE, additional, MOORE, DAVID, additional, MU, LIANGYI, additional, MURAVYEV, DMITRIY, additional, MURPHY, DERMOT, additional, NESZVEDA, GABOR, additional, NEUMEIER, CHRISTIAN, additional, NIELSSON, ULF, additional, NIMALENDRAN, MAHENDRARAJAH, additional, NOLTE, SVEN, additional, NORDEN, LARS L., additional, O'NEILL, PETER, additional, OBAID, KHALED, additional, ØDEGAARD, BERNT A., additional, ÖSTBERG, PER, additional, PAGNOTTA, EMILIANO, additional, PAINTER, MARCUS, additional, PALAN, STEFAN, additional, PALIT, IMON J., additional, PARK, ANDREAS, additional, PASCUAL, ROBERTO, additional, PASQUARIELLO, PAOLO, additional, PASTOR, LUBOS, additional, PATEL, VINAY, additional, PATTON, ANDREW J., additional, PEARSON, NEIL D., additional, PELIZZON, LORIANA, additional, PELLI, MICHELE, additional, PELSTER, MATTHIAS, additional, PÉRIGNON, CHRISTOPHE, additional, PFIFFER, CAMERON, additional, PHILIP, RICHARD, additional, PLÍHAL, TOMÁŠ, additional, PRAKASH, PUNEET, additional, PRESS, OLIVER‐ALEXANDER, additional, PRODROMOU, TINA, additional, PROKOPCZUK, MARCEL, additional, PUTNINS, TALIS, additional, QIAN, YA, additional, RAIZADA, GAURAV, additional, RAKOWSKI, DAVID, additional, RANALDO, ANGELO, additional, REGIS, LUCA, additional, REITZ, STEFAN, additional, RENAULT, THOMAS, additional, RENJIE, REX W., additional, RENO, ROBERTO, additional, RIDDIOUGH, STEVEN J., additional, RINNE, KALLE, additional, RINTAMÄKI, PAUL, additional, RIORDAN, RYAN, additional, RITTMANNSBERGER, THOMAS, additional, LONGARELA, IÑAKI RODRÍGUEZ, additional, ROESCH, DOMINIK, additional, ROGNONE, LAVINIA, additional, ROSEMAN, BRIAN, additional, ROŞU, IOANID, additional, ROY, SAURABH, additional, RUDOLF, NICOLAS, additional, RUSH, STEPHEN R., additional, RZAYEV, KHALADDIN, additional, RZEŹNIK, ALEKSANDRA A., additional, SANFORD, ANTHONY, additional, SANKARAN, HARIKUMAR, additional, SARKAR, ASANI, additional, SARNO, LUCIO, additional, SCAILLET, OLIVIER, additional, SCHARNOWSKI, STEFAN, additional, SCHENK‐HOPPÉ, KLAUS R., additional, SCHERTLER, ANDREA, additional, SCHNEIDER, MICHAEL, additional, SCHROEDER, FLORIAN, additional, SCHÜRHOFF, NORMAN, additional, SCHUSTER, PHILIPP, additional, SCHWARZ, MARCO A., additional, SEASHOLES, MARK S., additional, SEEGER, NORMAN J., additional, SHACHAR, OR, additional, SHKILKO, ANDRIY, additional, SHUI, JESSICA, additional, SIKIC, MARIO, additional, SIMION, GIORGIA, additional, SMALES, LEE A., additional, SÖDERLIND, PAUL, additional, SOJLI, ELVIRA, additional, SOKOLOV, KONSTANTIN, additional, SÖNKSEN, JANTJE, additional, SPOKEVICIUTE, LAIMA, additional, STEFANOVA, DENITSA, additional, SUBRAHMANYAM, MARTI G., additional, SZASZI, BARNABAS, additional, TALAVERA, OLEKSANDR, additional, TANG, YUEHUA, additional, TAYLOR, NICK, additional, THAM, WING WAH, additional, THEISSEN, ERIK, additional, THIMME, JULIAN, additional, TONKS, IAN, additional, TRAN, HAI, additional, TRAPIN, LUCA, additional, TROLLE, ANDERS B., additional, VADUVA, M. ANDREEA, additional, VALENTE, GIORGIO, additional, NESS, ROBERT A. VAN, additional, VASQUEZ, AURELIO, additional, VEROUSIS, THANOS, additional, VERWIJMEREN, PATRICK, additional, VILHELMSSON, ANDERS, additional, VILKOV, GRIGORY, additional, VLADIMIROV, VLADIMIR, additional, VOGEL, SEBASTIAN, additional, VOIGT, STEFAN, additional, WAGNER, WOLF, additional, WALTHER, THOMAS, additional, WEISS, PATRICK, additional, WEL, MICHEL VAN DER, additional, WERNER, INGRID M., additional, WESTERHOLM, P. JOAKIM, additional, WESTHEIDE, CHRISTIAN, additional, WIKA, HANS C., additional, WIPPLINGER, EVERT, additional, WOLF, MICHAEL, additional, WOLFF, CHRISTIAN C. P., additional, WOLK, LEONARD, additional, WONG, WING‐KEUNG, additional, WRAMPELMEYER, JAN, additional, WU, ZHEN‐XING, additional, XIA, SHUO, additional, XIU, DACHENG, additional, XU, KE, additional, XU, CAIHONG, additional, YADAV, PRADEEP K., additional, YAGÜE, JOSÉ, additional, YAN, CHENG, additional, YANG, ANTTI, additional, YOO, WOONGSUN, additional, YU, WENJIA, additional, YU, YIHE, additional, YU, SHIHAO, additional, YUESHEN, BART Z., additional, YUFEROVA, DARYA, additional, ZAMOJSKI, MARCIN, additional, ZAREEI, ABALFAZL, additional, ZEISBERGER, STEFAN M., additional, ZHANG, LU, additional, ZHANG, S. SARAH, additional, ZHANG, XIAOYU, additional, ZHAO, LU, additional, ZHONG, ZHUO, additional, ZHOU, Z. IVY, additional, ZHOU, CHEN, additional, ZHU, XINGYU S., additional, ZOICAN, MARIUS, additional, and ZWINKELS, REMCO, additional

Published
2024
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28. Novel HYLS1 variants associated with Joubert syndrome suggest potential genotype-phenotype correlates.

Author

Gana, Simone, D'Abrusco, Fulvio, Nicotra, Roberta, Ghiberti, Chiara, Catalano, Guido, Rognone, Elisa, Pichiecchio, Anna, Signorini, Sabrina, and Valente, Enza Maria

Abstract

Joubert syndrome (JS) is an inherited neurodevelopmental ciliopathy with wide clinical and genetic heterogeneity, whose paradigmatic sign is a peculiar cerebellar and brainstem malformation known as the 'molar tooth sign'. Recessive pathogenic variants in the HYLS1 gene are associated with hydrolethalus syndrome (HLS), a severe disorder characterised by multiple developmental defects leading to intrauterine or perinatal death. However, HYLS1 biallelic variants were also reported in three individuals with JS. Here, we report a fourth patient with a purely neurological JS carrying two compound heterozygous missense variants in the HYLS1 gene. Notably, while all patients with lethal HLS had both variants falling within the highly conserved HYLS-1 Box, the four patients with milder JS phenotype featured at least one variant external to this evolutionary conserved domain, suggesting a possible correlation between the mutation site and the severity of the phenotype. [ABSTRACT FROM AUTHOR]

Published
2025
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29. Quantitative MRI Harmonization to Maximize Clinical Impact: The RIN–Neuroimaging Network

Author

Anna Nigri, Stefania Ferraro, Claudia A. M. Gandini Wheeler-Kingshott, Michela Tosetti, Alberto Redolfi, Gianluigi Forloni, Egidio D'Angelo, Domenico Aquino, Laura Biagi, Paolo Bosco, Irene Carne, Silvia De Francesco, Greta Demichelis, Ruben Gianeri, Maria Marcella Lagana, Edoardo Micotti, Antonio Napolitano, Fulvia Palesi, Alice Pirastru, Giovanni Savini, Elisa Alberici, Carmelo Amato, Filippo Arrigoni, Francesca Baglio, Marco Bozzali, Antonella Castellano, Carlo Cavaliere, Valeria Elisa Contarino, Giulio Ferrazzi, Simona Gaudino, Silvia Marino, Vittorio Manzo, Luigi Pavone, Letterio S. Politi, Luca Roccatagliata, Elisa Rognone, Andrea Rossi, Caterina Tonon, Raffaele Lodi, Fabrizio Tagliavini, Maria Grazia Bruzzone, and The RIN–Neuroimaging

Subjects
harmonization, multisite, quantitative MRI, QSM, diffusion MRI, fMRI, Neurology. Diseases of the nervous system, RC346-429
Abstract

Neuroimaging studies often lack reproducibility, one of the cardinal features of the scientific method. Multisite collaboration initiatives increase sample size and limit methodological flexibility, therefore providing the foundation for increased statistical power and generalizable results. However, multisite collaborative initiatives are inherently limited by hardware, software, and pulse and sequence design heterogeneities of both clinical and preclinical MRI scanners and the lack of benchmark for acquisition protocols, data analysis, and data sharing. We present the overarching vision that yielded to the constitution of RIN-Neuroimaging Network, a national consortium dedicated to identifying disease and subject-specific in-vivo neuroimaging biomarkers of diverse neurological and neuropsychiatric conditions. This ambitious goal needs efforts toward increasing the diagnostic and prognostic power of advanced MRI data. To this aim, 23 Italian Scientific Institutes of Hospitalization and Care (IRCCS), with technological and clinical specialization in the neurological and neuroimaging field, have gathered together. Each IRCCS is equipped with high- or ultra-high field MRI scanners (i.e., ≥3T) for clinical or preclinical research or has established expertise in MRI data analysis and infrastructure. The actions of this Network were defined across several work packages (WP). A clinical work package (WP1) defined the guidelines for a minimum standard clinical qualitative MRI assessment for the main neurological diseases. Two neuroimaging technical work packages (WP2 and WP3, for clinical and preclinical scanners) established Standard Operative Procedures for quality controls on phantoms as well as advanced harmonized quantitative MRI protocols for studying the brain of healthy human participants and wild type mice. Under FAIR principles, a web-based e-infrastructure to store and share data across sites was also implemented (WP4). Finally, the RIN translated all these efforts into a large-scale multimodal data collection in patients and animal models with dementia (i.e., case study). The RIN-Neuroimaging Network can maximize the impact of public investments in research and clinical practice acquiring data across institutes and pathologies with high-quality and highly-consistent acquisition protocols, optimizing the analysis pipeline and data sharing procedures.

Published
2022
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30. Dermatological and Dermoscopic Baselines in BRCA Mutation Carriers

Author

Giovanni Paolino, Riccardo Pampena, Matteo Riccardo Di Nicola, Caterina Longo, Alessia Rognone, Stefania Zambelli, Giampaolo Bianchini, and Santo Raffaele Mercuri

Subjects
BRCA1, BRCA2, mutations, dermatology, skin, angiomas, Medicine (General), R5-920
Abstract

Breast cancer-associated genes 1 and 2 (BRCA1 and BRCA2) are tumor suppressor genes encoding a large protein that is involved in many essential biological processes. BRCA mutated patients show an increased risk to develop several malignancies, including cutaneous malignancies, although inconsistently across multiple studies. We carried out an observational study on the main dermatological and dermoscopic aspects in a population of patients with BRCA 1/2 mutations, to identify the main clinical and dermoscopical features in this class of patients. A total of 52 patients with BRCA mutations were included in the current analysis. Clinical, dermoscopical, and pathological data were obtained during the dermatologic visits. Out of the entire cohort, 67.3% of patients showed brown hairs and 63.5% of patients showed brown eyes, with phototype III as the most frequent phototype (69.2%). A total of 2.017 melanocytic lesions in all patients were analyzed; specifically, 40 patients (76.9%) showed a total number of nevi > 10, while regarding the main observed dermoscopic features, a prevalence of reticular pattern in 63% of cases was observed, followed by a mixed pattern in 19.2% of cases. Regarding the cutaneous examination, eruptive angiomas (eCAs) were the main dermatologic manifestations in 46.2% of patients. Out of 52 patients and during a follow-up of 24 months one patient developed an in situ melanoma. Interestingly, none of the patients with eCAs showed a TN > 10, highlighting an inverse correlation. To date, there is insufficient evidence to warrant increased surveillance in patients with BRCA mutations or with a positive family history for BRCA mutations, in the absence of standard cutaneous risk factors. Further studies with larger samples of patients are needed to better investigate dermatological and dermatoscopic features in BRCA mutation carriers.

Published
2022
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31. Non-Standard Errors

Author

Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, Van Dijk, Matthijs A., Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, and Van Dijk, Matthijs A.

Abstract

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.

Published
2024

32. Characterization of HER2-low breast cancer in young women with germline BRCA1/2 pathogenetic variants: Results of a large international retrospective cohort study

Author

Medisch Oncologische Disciplines, Pathologie, Cancer, Schettini, Francesco, Blondeaux, Eva, Molinelli, Chiara, Bas, Raphaëlle, Kim, Hee Jeong, Di Meglio, Antonio, Bernstein Molho, Rinat, Linn, Sabine C., Pogoda, Katarzyna, Carrasco, Estela, Punie, Kevin, Agostinetto, Elisa, Lopetegui-Lia, Nerea, Phillips, Kelly Anne, Toss, Angela, Rousset-Jablonski, Christine, Acheritogaray, Marion, Ferrari, Alberta, Paluch-Shimon, Shani, Fruscio, Robert, Cui, Wanda, Wong, Stephanie M., Vernieri, Claudio, Dieci, Maria Vittoria, Matikas, Alexios, Rozenblit, Mariya, Villarreal-Garza, Cynthia, De Marchis, Laura, Puglisi, Fabio, Vasconcelos de Matos, Leonor, Mariño, Monica, Teixeira, Luis, Graffeo, Rossella, Rognone, Alessia, Chirco, Alessandra, Antone, Nicoleta, Abdou, Yara, Marhold, Maximilian, Božović-Spasojević, Ivana, Cortés Salgado, Alfonso, Carmisciano, Luca, Bruzzone, Marco, Curigliano, Giuseppe, Prat, Aleix, Lambertini, Matteo, Medisch Oncologische Disciplines, Pathologie, Cancer, Schettini, Francesco, Blondeaux, Eva, Molinelli, Chiara, Bas, Raphaëlle, Kim, Hee Jeong, Di Meglio, Antonio, Bernstein Molho, Rinat, Linn, Sabine C., Pogoda, Katarzyna, Carrasco, Estela, Punie, Kevin, Agostinetto, Elisa, Lopetegui-Lia, Nerea, Phillips, Kelly Anne, Toss, Angela, Rousset-Jablonski, Christine, Acheritogaray, Marion, Ferrari, Alberta, Paluch-Shimon, Shani, Fruscio, Robert, Cui, Wanda, Wong, Stephanie M., Vernieri, Claudio, Dieci, Maria Vittoria, Matikas, Alexios, Rozenblit, Mariya, Villarreal-Garza, Cynthia, De Marchis, Laura, Puglisi, Fabio, Vasconcelos de Matos, Leonor, Mariño, Monica, Teixeira, Luis, Graffeo, Rossella, Rognone, Alessia, Chirco, Alessandra, Antone, Nicoleta, Abdou, Yara, Marhold, Maximilian, Božović-Spasojević, Ivana, Cortés Salgado, Alfonso, Carmisciano, Luca, Bruzzone, Marco, Curigliano, Giuseppe, Prat, Aleix, and Lambertini, Matteo

Published
2024

33. Nonstandard Errors

Author

Universidad de Alicante. Departamento de Economía Financiera y Contabilidad, Menkveld, Albert J., Dreber, Anna, Holzmeister, Felix, Huber, Juergen, Johannesson, Magnus, Kirchler, Michael, Neusüß, Sebastian, Razen, Michael, Weitzel, Utz, Abad, David, Abudy, Menachem (Meni), Adrian, Tobias, Ait-Sahalia, Yacine, Akmansoy, Olivier, Alcock, Jamie T., Alexeev, Vitali, Aloosh, Arash, Amato, Livia, Amaya, Diego, Angel, James J., Avetikian, Alejandro T., Bach, Amadeus, Baidoo, Edwin, Bakalli, Gaetan, Bao, Li, Barbon, Andrea, Bashchenko, Oksana, Bindra, Parampreet C., Bjønnes, Geir H., Black, Jeffrey R., Black, Bernard S., Bogoev, Dimitar, Bohorquez Correa, Santiago, Bondarenko, Oleg, Bos, Charles S., Bosch-Rosa, Ciril, Bouri, Elie, Brownlees, Christian, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera Romero, Laura M., Caporin, Massimiliano, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chen, Jian, Chernov, Mikhail, Cheung, William, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung-Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca F., Declerck, Fany, Deev, Oleg, Degryse, Hans, Deku, Solomon Y., Desagre, Christophe, Van Dijk, Mathijs A., Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip A., Dudda, Tom, Duevski, Teodor, Dumitrescu, Ariadna, Dyakov, Teodor, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, Ellen, Saskia Ter, Eugster, Nicolas, Evans, Martin D. D., Farrell, Michael, Felez-Vinas, Ester, Ferrara, Gerardo, Ferrouhi, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan T., Foley, Sean D. V., Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco, Frijns, Bart, Frömmel, Michael, Fu, Servanna M., Füllbrunn, Sascha C., Gan, Baoqing, Gao, Ge, Gehrig, Thomas P., Gemayel, Roland, Gerritsen, Dirk, Gil-Bazo, Javier, Gilder, Dudley, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Grammig, Joachim, Grégoire, Vincent, Güçbilmez, Ufuk, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, He, Xue-Zhong (Tony), Heath, Davidson, Hediger, Simon, Hendershott, Terrence, Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth A., Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ilczuk, Konrad, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylhä, Petri, Kaeck, Andreas T., Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, Van Kervel, Vincent, Khan, Saad A., Khomyn, Marta K., Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Krahnen, Jan P., Kuhle, Paul, Kwan, Amy, Lajaunie, Quentin, Lam, F. Y. Eric C., Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, Hui, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver, Liu, Jiacheng, Liu, Anqi, Llorente, Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis, Lopez-Lira, Alejandro, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah, Mi, Michael G., Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Norden, Lars L., O'neill, Peter, Obaid, Khaled, Ødegaard, Bernt A., Östberg, Per, Pagnotta, Emiliano, Painter, Marcus, Palan, Stefan, Palit, Imon J., Park, Andreas, Pascual, Roberto, Pasquariello, Paolo, Pastor, Lubos, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelli, Michele, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Press, Oliver-Alexander, Prodromou, Tina, Prokopczuk, Marcel, Putnins, Talis, Qian, Ya, Raizada, Gaurav, Rakowski, David, Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Renjie, Rex W., Reno, Roberto, Riddiough, Steven J., Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Roesch, Dominik, Rognone, Lavinia, Roseman, Brian, Roşu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen R., Rzayev, Khaladdin, Rzeźnik, Aleksandra A., Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus R., Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Seeger, Norman J., Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Sönksen, Jantje, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nick, Tham, Wing Wah, Theissen, Erik, Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Vaduva, M. Andreea, Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, Van Der Wel, Michel, Werner, Ingrid M., Westerholm, P. Joakim, Westheide, Christian, Wika, Hans C., Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Wu, Zhen-Xing, Xia, Shuo, Xiu, Dacheng, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Yihe, Yu, Shihao, Yueshen, Bart Z., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan M., Zhang, Lu, Zhang, S. Sarah, Zhang, Xiaoyu, Zhao, Lu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu S., Zoican, Marius, Zwinkels, Remco, Universidad de Alicante. Departamento de Economía Financiera y Contabilidad, Menkveld, Albert J., Dreber, Anna, Holzmeister, Felix, Huber, Juergen, Johannesson, Magnus, Kirchler, Michael, Neusüß, Sebastian, Razen, Michael, Weitzel, Utz, Abad, David, Abudy, Menachem (Meni), Adrian, Tobias, Ait-Sahalia, Yacine, Akmansoy, Olivier, Alcock, Jamie T., Alexeev, Vitali, Aloosh, Arash, Amato, Livia, Amaya, Diego, Angel, James J., Avetikian, Alejandro T., Bach, Amadeus, Baidoo, Edwin, Bakalli, Gaetan, Bao, Li, Barbon, Andrea, Bashchenko, Oksana, Bindra, Parampreet C., Bjønnes, Geir H., Black, Jeffrey R., Black, Bernard S., Bogoev, Dimitar, Bohorquez Correa, Santiago, Bondarenko, Oleg, Bos, Charles S., Bosch-Rosa, Ciril, Bouri, Elie, Brownlees, Christian, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera Romero, Laura M., Caporin, Massimiliano, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chen, Jian, Chernov, Mikhail, Cheung, William, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung-Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca F., Declerck, Fany, Deev, Oleg, Degryse, Hans, Deku, Solomon Y., Desagre, Christophe, Van Dijk, Mathijs A., Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip A., Dudda, Tom, Duevski, Teodor, Dumitrescu, Ariadna, Dyakov, Teodor, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, Ellen, Saskia Ter, Eugster, Nicolas, Evans, Martin D. D., Farrell, Michael, Felez-Vinas, Ester, Ferrara, Gerardo, Ferrouhi, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan T., Foley, Sean D. V., Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco, Frijns, Bart, Frömmel, Michael, Fu, Servanna M., Füllbrunn, Sascha C., Gan, Baoqing, Gao, Ge, Gehrig, Thomas P., Gemayel, Roland, Gerritsen, Dirk, Gil-Bazo, Javier, Gilder, Dudley, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Grammig, Joachim, Grégoire, Vincent, Güçbilmez, Ufuk, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, He, Xue-Zhong (Tony), Heath, Davidson, Hediger, Simon, Hendershott, Terrence, Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth A., Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ilczuk, Konrad, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylhä, Petri, Kaeck, Andreas T., Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, Van Kervel, Vincent, Khan, Saad A., Khomyn, Marta K., Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Krahnen, Jan P., Kuhle, Paul, Kwan, Amy, Lajaunie, Quentin, Lam, F. Y. Eric C., Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, Hui, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver, Liu, Jiacheng, Liu, Anqi, Llorente, Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis, Lopez-Lira, Alejandro, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah, Mi, Michael G., Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Norden, Lars L., O'neill, Peter, Obaid, Khaled, Ødegaard, Bernt A., Östberg, Per, Pagnotta, Emiliano, Painter, Marcus, Palan, Stefan, Palit, Imon J., Park, Andreas, Pascual, Roberto, Pasquariello, Paolo, Pastor, Lubos, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelli, Michele, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Press, Oliver-Alexander, Prodromou, Tina, Prokopczuk, Marcel, Putnins, Talis, Qian, Ya, Raizada, Gaurav, Rakowski, David, Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Renjie, Rex W., Reno, Roberto, Riddiough, Steven J., Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Roesch, Dominik, Rognone, Lavinia, Roseman, Brian, Roşu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen R., Rzayev, Khaladdin, Rzeźnik, Aleksandra A., Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus R., Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Seeger, Norman J., Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Sönksen, Jantje, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nick, Tham, Wing Wah, Theissen, Erik, Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Vaduva, M. Andreea, Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, Van Der Wel, Michel, Werner, Ingrid M., Westerholm, P. Joakim, Westheide, Christian, Wika, Hans C., Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Wu, Zhen-Xing, Xia, Shuo, Xiu, Dacheng, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Yihe, Yu, Shihao, Yueshen, Bart Z., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan M., Zhang, Lu, Zhang, S. Sarah, Zhang, Xiaoyu, Zhao, Lu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu S., Zoican, Marius, and Zwinkels, Remco

Abstract

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.

Published
2024

34. Nonstandard Errors

Author

MENKVELD, AJ, DREBER, A, HOLZMEISTER, F, HUBER, J, JOHANNESSON, M, KIRCHLER, M, NEUSÜß, S, RAZEN, M, WEITZEL, U, ABAD‐DÍAZ, D, ABUDY, M, MANO, N, MARCHAL, A, MARTINEAU, C, MAZZOLA, F, MELOSO, D, MI, MG, MIHET, R, MOHAN, V, MOINAS, S, ANGEL, JJ, GEMAYEL, R, MOORE, D, MU, L, MURAVYEV, D, MURPHY, D, NESZVEDA, G, NEUMEIER, C, NIELSSON, U, NIMALENDRAN, M, NOLTE, S, NORDEN, LL, GERRITSEN, D, AVETIKIAN, AT, O'NEILL, P, OBAID, K, ØDEGAARD, BA, ÖSTBERG, P, PAGNOTTA, E, PAINTER, M, PALAN, S, PALIT, IJ, PARK, A, GIL‐BAZO, J, PASCUAL, R, BACH, A, PASQUARIELLO, P, PASTOR, L, PATEL, V, PATTON, AJ, PEARSON, ND, PELIZZON, L, PELLI, M, PELSTER, M, GILDER, D, PÉRIGNON, C, PFIFFER, C, BAIDOO, E, PHILIP, R, PLÍHAL, T, PRAKASH, P, PRESS, O, PRODROMOU, T, PROKOPCZUK, M, PUTNINS, T, GLOSTEN, LR, QIAN, Y, RAIZADA, G, RAKOWSKI, D, BAKALLI, G, RANALDO, A, REGIS, L, REITZ, S, RENAULT, T, RENJIE, RW, RENO, R, GOMEZ, T, RIDDIOUGH, SJ, RINNE, K, RINTAMÄKI, P, RIORDAN, R, BAO, L, RITTMANNSBERGER, T, LONGARELA, IR, ROESCH, D, ROGNONE, L, ROSEMAN, B, GORBENKO, A, ROŞU, I, ROY, S, RUDOLF, N, RUSH, SR, RZAYEV, K, BARBON, A, RZEŹNIK, AA, SANFORD, A, SANKARAN, H, SARKAR, A, GRAMMIG, J, SARNO, L, SCAILLET, O, SCHARNOWSKI, S, SCHENK‐HOPPÉ, KR, SCHERTLER, A, SCHNEIDER, M, BASHCHENKO, O, SCHROEDER, F, SCHÜRHOFF, N, SCHUSTER, P, GRÉGOIRE, V, SCHWARZ, MA, SEASHOLES, MS, SEEGER, NJ, SHACHAR, O, SHKILKO, A, SHUI, J, SIKIC, M, BINDRA, PC, SIMION, G, SMALES, LA, GÜÇBILMEZ, U, SÖDERLIND, P, SOJLI, E, SOKOLOV, K, SÖNKSEN, J, SPOKEVICIUTE, L, STEFANOVA, D, SUBRAHMANYAM, MG, SZASZI, B, BJØNNES, GH, TALAVERA, O, ADRIAN, T, TANG, Y, TAYLOR, N, THAM, W, THEISSEN, E, THIMME, J, TONKS, I, TRAN, H, TRAPIN, L, TROLLE, AB, BLACK, JR, HAGSTRÖMER, B, VADUVA, MA, VALENTE, G, VAN NESS, RA, VASQUEZ, A, VEROUSIS, T, VERWIJMEREN, P, VILHELMSSON, A, VILKOV, G, VLADIMIROV, V, VOGEL, S, HAMBUCKERS, J, BLACK, BS, VOIGT, S, WAGNER, W, WALTHER, T, WEISS, P, VAN DER WEL, M, WERNER, IM, WESTERHOLM, PJ, WESTHEIDE, C, WIKA, HC, HAPNES, E, WIPPLINGER, E, BOGOEV, D, WOLF, M, WOLFF, CCP, WOLK, L, WONG, W, WRAMPELMEYER, J, WU, Z, XIA, S, XIU, D, HARRIS, JH, XU, K, XU, C, CORREA, SB, YADAV, PK, YAGÜE, J, YAN, C, YANG, A, YOO, W, YU, W, YU, Y, HARRIS, L, YU, S, YUESHEN, BZ, YUFEROVA, D, BONDARENKO, O, ZAMOJSKI, M, ZAREEI, A, ZEISBERGER, SM, ZHANG, L, ZHANG, SS, ZHANG, X, HARTMANN, S, ZHAO, L, ZHONG, Z, ZHOU, ZI, ZHOU, C, BOS, CS, ZHU, XS, ZOICAN, M, ZWINKELS, R, BOSCH‐ROSA, C, BOURI, E, HASSE, J, BROWNLEES, C, CALAMIA, A, CAO, VN, CAPELLE‐BLANCARD, G, ROMERO, LMC, CAPORIN, M, CARRION, A, CASKURLU, T, CHAKRABARTY, B, CHEN, J, HAUTSCH, N, CHERNOV, M, CHEUNG, W, CHINCARINI, LB, CHORDIA, T, CHOW, S, CLAPHAM, B, COLLIARD, J, COMERTON‐FORDE, C, CURRAN, E, DAO, T, HE, X, DARE, W, DAVIES, RJ, DE BLASIS, R, DE NARD, GF, DECLERCK, F, DEEV, O, DEGRYSE, H, DEKU, SY, DESAGRE, C, VAN DIJK, MA, HEATH, D, DIM, C, DIMPFL, T, DONG, YJ, DRUMMOND, PA, DUDDA, T, DUEVSKI, T, DUMITRESCU, A, DYAKOV, T, DYHRBERG, AH, DZIELIŃSKI, M, AIT‐SAHALIA, Y, EKSI, A, KALAK, IE, ELLEN, ST, EUGSTER, N, EVANS, MDD, FARRELL, M, FELEZ‐VINAS, E, FERRARA, G, FERROUHI, EM, FLORI, A, HEDIGER, S, FLUHARTY‐JAIDEE, JT, FOLEY, SDV, FONG, KYL, FOUCAULT, T, FRANUS, T, FRANZONI, F, FRIJNS, B, FRÖMMEL, M, FU, SM, FÜLLBRUNN, SC, HENDERSHOTT, T, GAN, B, GAO, G, GEHRIG, TP, HIBBERT, AM, HJALMARSSON, E, HOELSCHER, SA, HOFFMANN, P, HOLDEN, CW, HORENSTEIN, AR, HUANG, W, HUANG, D, AKMANSOY, O, HURLIN, C, ILCZUK, K, IVASHCHENKO, A, IYER, SR, JAHANSHAHLOO, H, JALKH, N, JONES, CM, JURKATIS, S, JYLHÄ, P, KAECK, AT, ALCOCK, JT, KAISER, G, KARAM, A, KARMAZIENE, E, KASSNER, B, KAUSTIA, M, KAZAK, E, KEARNEY, F, VAN KERVEL, V, KHAN, SA, KHOMYN, MK, ALEXEEV, V, KLEIN, T, KLEIN, O, KLOS, A, KOETTER, M, KOLOKOLOV, A, KORAJCZYK, RA, KOZHAN, R, KRAHNEN, JP, KUHLE, P, KWAN, A, ALOOSH, A, LAJAUNIE, Q, LAM, FYEC, LAMBERT, M, LANGLOIS, H, LAUSEN, J, LAUTER, T, LEIPPOLD, M, LEVIN, V, LI, Y, LI, H, AMATO, L, LIEW, CY, LINDNER, T, LINTON, O, LIU, J, LIU, A, LLORENTE, G, LOF, M, LOHR, A, LONGSTAFF, F, LOPEZ‐LIRA, A, AMAYA, D, MANKAD, S, MENKVELD, AJ, DREBER, A, HOLZMEISTER, F, HUBER, J, JOHANNESSON, M, KIRCHLER, M, NEUSÜß, S, RAZEN, M, WEITZEL, U, ABAD‐DÍAZ, D, ABUDY, M, MANO, N, MARCHAL, A, MARTINEAU, C, MAZZOLA, F, MELOSO, D, MI, MG, MIHET, R, MOHAN, V, MOINAS, S, ANGEL, JJ, GEMAYEL, R, MOORE, D, MU, L, MURAVYEV, D, MURPHY, D, NESZVEDA, G, NEUMEIER, C, NIELSSON, U, NIMALENDRAN, M, NOLTE, S, NORDEN, LL, GERRITSEN, D, AVETIKIAN, AT, O'NEILL, P, OBAID, K, ØDEGAARD, BA, ÖSTBERG, P, PAGNOTTA, E, PAINTER, M, PALAN, S, PALIT, IJ, PARK, A, GIL‐BAZO, J, PASCUAL, R, BACH, A, PASQUARIELLO, P, PASTOR, L, PATEL, V, PATTON, AJ, PEARSON, ND, PELIZZON, L, PELLI, M, PELSTER, M, GILDER, D, PÉRIGNON, C, PFIFFER, C, BAIDOO, E, PHILIP, R, PLÍHAL, T, PRAKASH, P, PRESS, O, PRODROMOU, T, PROKOPCZUK, M, PUTNINS, T, GLOSTEN, LR, QIAN, Y, RAIZADA, G, RAKOWSKI, D, BAKALLI, G, RANALDO, A, REGIS, L, REITZ, S, RENAULT, T, RENJIE, RW, RENO, R, GOMEZ, T, RIDDIOUGH, SJ, RINNE, K, RINTAMÄKI, P, RIORDAN, R, BAO, L, RITTMANNSBERGER, T, LONGARELA, IR, ROESCH, D, ROGNONE, L, ROSEMAN, B, GORBENKO, A, ROŞU, I, ROY, S, RUDOLF, N, RUSH, SR, RZAYEV, K, BARBON, A, RZEŹNIK, AA, SANFORD, A, SANKARAN, H, SARKAR, A, GRAMMIG, J, SARNO, L, SCAILLET, O, SCHARNOWSKI, S, SCHENK‐HOPPÉ, KR, SCHERTLER, A, SCHNEIDER, M, BASHCHENKO, O, SCHROEDER, F, SCHÜRHOFF, N, SCHUSTER, P, GRÉGOIRE, V, SCHWARZ, MA, SEASHOLES, MS, SEEGER, NJ, SHACHAR, O, SHKILKO, A, SHUI, J, SIKIC, M, BINDRA, PC, SIMION, G, SMALES, LA, GÜÇBILMEZ, U, SÖDERLIND, P, SOJLI, E, SOKOLOV, K, SÖNKSEN, J, SPOKEVICIUTE, L, STEFANOVA, D, SUBRAHMANYAM, MG, SZASZI, B, BJØNNES, GH, TALAVERA, O, ADRIAN, T, TANG, Y, TAYLOR, N, THAM, W, THEISSEN, E, THIMME, J, TONKS, I, TRAN, H, TRAPIN, L, TROLLE, AB, BLACK, JR, HAGSTRÖMER, B, VADUVA, MA, VALENTE, G, VAN NESS, RA, VASQUEZ, A, VEROUSIS, T, VERWIJMEREN, P, VILHELMSSON, A, VILKOV, G, VLADIMIROV, V, VOGEL, S, HAMBUCKERS, J, BLACK, BS, VOIGT, S, WAGNER, W, WALTHER, T, WEISS, P, VAN DER WEL, M, WERNER, IM, WESTERHOLM, PJ, WESTHEIDE, C, WIKA, HC, HAPNES, E, WIPPLINGER, E, BOGOEV, D, WOLF, M, WOLFF, CCP, WOLK, L, WONG, W, WRAMPELMEYER, J, WU, Z, XIA, S, XIU, D, HARRIS, JH, XU, K, XU, C, CORREA, SB, YADAV, PK, YAGÜE, J, YAN, C, YANG, A, YOO, W, YU, W, YU, Y, HARRIS, L, YU, S, YUESHEN, BZ, YUFEROVA, D, BONDARENKO, O, ZAMOJSKI, M, ZAREEI, A, ZEISBERGER, SM, ZHANG, L, ZHANG, SS, ZHANG, X, HARTMANN, S, ZHAO, L, ZHONG, Z, ZHOU, ZI, ZHOU, C, BOS, CS, ZHU, XS, ZOICAN, M, ZWINKELS, R, BOSCH‐ROSA, C, BOURI, E, HASSE, J, BROWNLEES, C, CALAMIA, A, CAO, VN, CAPELLE‐BLANCARD, G, ROMERO, LMC, CAPORIN, M, CARRION, A, CASKURLU, T, CHAKRABARTY, B, CHEN, J, HAUTSCH, N, CHERNOV, M, CHEUNG, W, CHINCARINI, LB, CHORDIA, T, CHOW, S, CLAPHAM, B, COLLIARD, J, COMERTON‐FORDE, C, CURRAN, E, DAO, T, HE, X, DARE, W, DAVIES, RJ, DE BLASIS, R, DE NARD, GF, DECLERCK, F, DEEV, O, DEGRYSE, H, DEKU, SY, DESAGRE, C, VAN DIJK, MA, HEATH, D, DIM, C, DIMPFL, T, DONG, YJ, DRUMMOND, PA, DUDDA, T, DUEVSKI, T, DUMITRESCU, A, DYAKOV, T, DYHRBERG, AH, DZIELIŃSKI, M, AIT‐SAHALIA, Y, EKSI, A, KALAK, IE, ELLEN, ST, EUGSTER, N, EVANS, MDD, FARRELL, M, FELEZ‐VINAS, E, FERRARA, G, FERROUHI, EM, FLORI, A, HEDIGER, S, FLUHARTY‐JAIDEE, JT, FOLEY, SDV, FONG, KYL, FOUCAULT, T, FRANUS, T, FRANZONI, F, FRIJNS, B, FRÖMMEL, M, FU, SM, FÜLLBRUNN, SC, HENDERSHOTT, T, GAN, B, GAO, G, GEHRIG, TP, HIBBERT, AM, HJALMARSSON, E, HOELSCHER, SA, HOFFMANN, P, HOLDEN, CW, HORENSTEIN, AR, HUANG, W, HUANG, D, AKMANSOY, O, HURLIN, C, ILCZUK, K, IVASHCHENKO, A, IYER, SR, JAHANSHAHLOO, H, JALKH, N, JONES, CM, JURKATIS, S, JYLHÄ, P, KAECK, AT, ALCOCK, JT, KAISER, G, KARAM, A, KARMAZIENE, E, KASSNER, B, KAUSTIA, M, KAZAK, E, KEARNEY, F, VAN KERVEL, V, KHAN, SA, KHOMYN, MK, ALEXEEV, V, KLEIN, T, KLEIN, O, KLOS, A, KOETTER, M, KOLOKOLOV, A, KORAJCZYK, RA, KOZHAN, R, KRAHNEN, JP, KUHLE, P, KWAN, A, ALOOSH, A, LAJAUNIE, Q, LAM, FYEC, LAMBERT, M, LANGLOIS, H, LAUSEN, J, LAUTER, T, LEIPPOLD, M, LEVIN, V, LI, Y, LI, H, AMATO, L, LIEW, CY, LINDNER, T, LINTON, O, LIU, J, LIU, A, LLORENTE, G, LOF, M, LOHR, A, LONGSTAFF, F, LOPEZ‐LIRA, A, AMAYA, D, and MANKAD, S

Abstract

ABSTRACTIn statistics, samples are drawn from a population in a data‐generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence‐generating process (EGP). We claim that EGP variation across researchers adds uncertainty—nonstandard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for more reproducible or higher rated research. Adding peer‐review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants.

Published
2024

35. Non-Standard Errors

Author

Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, Van Dijk, Matthijs A., Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Finance, UU LEG Research UUSE Multidisciplinary Economics, Sub General Pharmaceutics, Menkveld, Albert J., Abudy, Menachem (Meni), Grammig, Joachim, Gregoire, Vincent, Hagströmer, Björn, Hambuckers, Julien, Hapnes, Erik, Harris, Jeffrey H., Harris, Lawrence, Hartmann, Simon, Hasse, Jean-Baptiste, Hautsch, Nikolaus, Adrian, Tobias, He, Xue-Zhong 'Tony', Heath, Davidson, Hediger, Simon, Hendershott, Terrence J., Hibbert, Ann Marie, Hjalmarsson, Erik, Hoelscher, Seth, Hoffmann, Peter, Holden, Craig W., Horenstein, Alex R., Ait-Sahalia, Yacine, Huang, Wenqian, Huang, Da, Hurlin, Christophe, Ivashchenko, Alexey, Iyer, Subramanian R., Jahanshahloo, Hossein, Jalkh, Naji, Jones, Charles M., Jurkatis, Simon, Jylha, Petri, Akmansoy, Olivier, Kaeck, Andreas, Kaiser, Gabriel, Karam, Arzé, Karmaziene, Egle, Kassner, Bernhard, Kaustia, Markku, Kazak, Ekaterina, Kearney, Fearghal, van Kervel, Vincent, Khan, Saad, Alcock, Jamie, Khomyn, Marta, Klein, Tony, Klein, Olga, Klos, Alexander, Koetter, Michael, Krahnen, Jan Pieter, Kolokolov, Aleksey, Korajczyk, Robert A., Kozhan, Roman, Kwan, Amy, Alexeev, Vitali, Lajaunie, Quentin, Lam, Full Yet Eric Campbell, Lambert, Marie, Langlois, Hugues, Lausen, Jens, Lauter, Tobias, Leippold, Markus, Levin, Vladimir, Li, Yijie, Li, (Michael) Hui, Aloosh, Arash, Liew, Chee Yoong, Lindner, Thomas, Linton, Oliver B., Liu, Jiacheng, Liu, Anqi, Llorente-Alvarez, Jesus-Guillermo, Lof, Matthijs, Lohr, Ariel, Longstaff, Francis A., Lopez-Lira, Alejandro, Amato, Livia, Mankad, Shawn, Mano, Nicola, Marchal, Alexis, Martineau, Charles, Mazzola, Francesco, Meloso, Debrah C, Mihet, Roxana, Mohan, Vijay, Moinas, Sophie, Moore, David, Amaya, Diego, Mu, Liangyi, Muravyev, Dmitriy, Murphy, Dermot, Neszveda, Gabor, Neumeier, Christian, Nielsson, Ulf, Nimalendran, Mahendrarajah, Nolte, Sven, Nordén, Lars L., O'Neill, Peter, Angel, James J., Obaid, Khaled, Ødegaard, Bernt Arne, Östberg, Per, Painter, Marcus, Palan, Stefan, Palit, Imon, Park, Andreas, Pascual Gascó, Roberto, Pasquariello, Paolo, Pastor, Lubos, Dreber, Anna, Bach, Amadeus, Patel, Vinay, Patton, Andrew J., Pearson, Neil D., Pelizzon, Loriana, Pelster, Matthias, Pérignon, Christophe, Pfiffer, Cameron, Philip, Richard, Plíhal, Tomáš, Prakash, Puneet, Baidoo, Edwin, Press, Oliver-Alexander, Prodromou, Tina, Putnins, Talis J., Raizada, Gaurav, Rakowski, David A., Ranaldo, Angelo, Regis, Luca, Reitz, Stefan, Renault, Thomas, Wang, Renjie, Bakalli, Gaetan, Renò, Roberto, Riddiough, Steven, Rinne, Kalle, Rintamäki, Paul, Riordan, Ryan, Rittmannsberger, Thomas, Rodríguez Longarela, Iñaki, Rösch, Dominik, Rognone, Lavinia, Roseman, Brian, Barbon, Andrea, Rosu, Ioanid, Roy, Saurabh, Rudolf, Nicolas, Rush, Stephen, Rzayev, Khaladdin, Rzeźnik, Aleksandra, Sanford, Anthony, Sankaran, Harikumar, Sarkar, Asani, Sarno, Lucio, Bashchenko, Oksana, Scaillet, Olivier, Scharnowski, Stefan, Schenk-Hoppé, Klaus Reiner, Schertler, Andrea, Schneider, Michael, Schroeder, Florian, Schürhoff, Norman, Schuster, Philipp, Schwarz, Marco A., Seasholes, Mark S., Bindra, Parampreet Christopher, Seeger, Norman, Shachar, Or, Shkilko, Andriy, Shui, Jessica, Sikic, Mario, Simion, Giorgia, Smales, Lee A., Söderlind, Paul, Sojli, Elvira, Sokolov, Konstantin, Bjonnes, Geir Hoidal, Spokeviciute, Laima, Stefanova, Denitsa, Subrahmanyam, Marti G., Neusüss, Sebastian, Szaszi, Barnabas, Talavera, Oleksandr, Tang, Yuehua, Taylor, Nicholas, Tham, Wing Wah, Theissen, Erik, Black, Jeffrey R., Thimme, Julian, Tonks, Ian, Tran, Hai, Trapin, Luca, Trolle, Anders B., Valente, Giorgio, Van Ness, Robert A., Vasquez, Aurelio, Verousis, Thanos, Verwijmeren, Patrick, Black, Bernard S., Vilhelmsson, Anders, Vilkov, Grigory, Vladimirov, Vladimir, Vogel, Sebastian, Voigt, Stefan, Wagner, Wolf, Walther, Thomas, Weiss, Patrick, van der Wel, Michel, Werner, Ingrid M., Bohorquez, Santiago, Westerholm, P. Joakim, Westheide, Christian, Wipplinger, Evert, Wolf, Michael, Wolff, Christian C. P., Wolk, Leonard, Wong, Wing-Keung, Wrampelmeyer, Jan, Xia, Shuo, Xiu, Dacheng, Holzmeister, Felix, Bondarenko, Oleg, Xu, Ke, Xu, Caihong, Yadav, Pradeep K., Yagüe, José, Yan, Cheng, Yang, Antti, Yoo, Woongsun, Yu, Wenjia, Yu, Shihao, Yueshen, Bart Zhou, Bos, Charles S., Yuferova, Darya, Zamojski, Marcin, Zareei, Abalfazl, Zeisberger, Stefan, Zhang, Lu, Zhang, Xiaoyu, Zhong, Zhuo, Zhou, Z. Ivy, Zhou, Chen, Zhu, Xingyu, Bosch-Rosa, Ciril, Zoican, Marius, Zwinkels, Remco C.J., Chen, Jian, Duevski, Teodor, Gao, Ge, Gemayel, Roland, Gilder, Dudley, Kuhle, Paul, Pagnotta, Emiliano, Pelli, Michele, Bouri, Elie, Sönksen, Jantje, Ilczuk, Konrad, Bogoev, Dimitar, Qian, Ya, Wika, Hans C., Yu, Yihe, Zhao, Lu, Mi, Michael, Bao, Li, Brownlees, Christian T., Vaduva, Andreea, Prokopczuk, Marcel, Avetikian, Alejandro, Wu, Zhen-Xing, Calamia, Anna, Cao, Viet Nga, Capelle-Blancard, Gunther, Capera, Laura, Caporin, Massimiliano, Huber, Juergen, Carrion, Allen, Caskurlu, Tolga, Chakrabarty, Bidisha, Chernov, Mikhail, Cheung, William Ming Yan, Chincarini, Ludwig B., Chordia, Tarun, Chow, Sheung Chi, Clapham, Benjamin, Colliard, Jean-Edouard, Johanneson, Magnus, Comerton-Forde, Carole, Curran, Edward, Dao, Thong, Dare, Wale, Davies, Ryan J., De Blasis, Riccardo, De Nard, Gianluca, Declerck, Fany, Deev, Oleg, Degryse, Hans, Kirchler, Michael, Deku, Solomon, Desagre, Christophe, Dim, Chukwuma, Dimpfl, Thomas, Dong, Yun Jiang, Drummond, Philip, Dudda, Tom, Dumitrescu, Ariadna, Dyakov, Teodor, Razen, Michael, Dyhrberg, Anne Haubo, Dzieliński, Michał, Eksi, Asli, El Kalak, Izidin, ter Ellen, Saskia, Eugster, Nicolas, Evans, Martin D.D., Farrell, Michael, Félez-Viñas, Ester, Ferrara, Gerardo, Weitzel, Utz, FERROUHI, El Mehdi, Flori, Andrea, Fluharty-Jaidee, Jonathan, Foley, Sean, Fong, Kingsley Y. L., Foucault, Thierry, Franus, Tatiana, Franzoni, Francesco A., Frijns, Bart, Frömmel, Michael, Abad, David, Fu, Servanna Mianjun, Füllbrunn, Sascha, Gan, Baoqing, Gehrig, Thomas, Gerritsen, Dirk, Gil-Bazo, Javier, Glosten, Lawrence R., Gomez, Thomas, Gorbenko, Arseny, Güçbilmez, Ufuk, and Van Dijk, Matthijs A.

Published
2024

36. Non-Standard Errors

Author

Menkveld, AJ, Dreber, A, Holzmeister, F, Huber, J, Johanneson, M, Kirchler, M, Razen, M, Weitzel, U, Abad, D, Abudy, MM, Adrian, T, Gregoire, V, Hagströmer, B, Hambuckers, J, Hapnes, E, Harris, JH, Harris, L, Hartmann, S, Hasse, J-B, Hautsch, N, He, X-ZT, Ait-Sahalia, Y, Heath, D, Hediger, S, Hendershott, TJ, Hibbert, AM, Hjalmarsson, E, Hoelscher, S, Hoffmann, P, Holden, CW, Horenstein, AR, Huang, W, Akmansoy, O, Huang, D, Hurlin, C, Ivashchenko, A, Iyer, SR, Jahanshahloo, H, Jalkh, N, Jones, CM, Jurkatis, S, Jylha, P, Kaeck, A, Alcock, J, Kaiser, G, Karam, A, Karmaziene, E, Kassner, B, Kaustia, M, Kazak, E, Kearney, F, van Kervel, V, Khan, S, Khomyn, M, Alexeev, V, Klein, T, Klein, O, Klos, A, Koetter, M, Krahnen, JP, Kolokolov, A, Korajczyk, RA, Kozhan, R, Kwan, A, Lajaunie, Q, Aloosh, A, Lam, FYEC, Lambert, M, Langlois, H, Lausen, J, Lauter, T, Leippold, M, Levin, V, Li, Y, Li, MH, Liew, CY, Amato, L, Lindner, T, Linton, OB, Liu, J, Liu, A, Llorente-Alvarez, J-G, Lof, M, Lohr, A, Longstaff, FA, Lopez-Lira, A, Mankad, S, Amaya, D, Mano, N, Marchal, A, Martineau, C, Mazzola, F, Meloso, DC, Mihet, R, Mohan, V, Moinas, S, Moore, D, Mu, L, Angel, JJ, Muravyev, D, Murphy, D, Neszveda, G, Neumeier, C, Nielsson, U, Nimalendran, M, Nolte, S, Nordén, LL, O'Neill, P, Obaid, K, Bach, A, Ødegaard, BA, Östberg, P, Painter, M, Palan, S, Palit, I, Park, A, Pascual Gascó, R, Pasquariello, P, Pastor, L, Patel, V, Baidoo, E, Patton, AJ, Pearson, ND, Pelizzon, L, Pelster, M, Pérignon, C, Pfiffer, C, Philip, R, Plíhal, T, Prakash, P, Press, O-A, Bakalli, G, Prodromou, T, Putnins, TJ, Raizada, G, Rakowski, DA, Ranaldo, A, Regis, L, Reitz, S, Renault, T, Wang, R, Renò, R, Barbon, A, Riddiough, S, Rinne, K, Rintamäki, P, Riordan, R, RITTMANNSBERGER, T, Rodríguez Longarela, I, Rösch, D, Rognone, L, Roseman, B, Rosu, I, Bashchenko, O, Roy, S, Rudolf, N, Rush, S, Rzayev, K, Rzeźnik, A, Sanford, A, Sankaran, H, Sarkar, A, Sarno, L, Scaillet, O, Bindra, PC, Scharnowski, S, Schenk-Hoppé, KR, Schertler, A, Schneider, M, Schroeder, F, Schürhoff, N, Schuster, P, Schwarz, MA, Seasholes, MS, Seeger, N, Bjonnes, GH, Shachar, O, Shkilko, A, Shui, J, Sikic, M, Simion, G, Smales, LA, Söderlind, P, Sojli, E, Sokolov, K, Spokeviciute, L, Black, JR, Stefanova, D, Subrahmanyam, MG, Neusüss, S, Szaszi, B, Talavera, O, Tang, Y, Taylor, N, Tham, WW, Theissen, E, Thimme, J, Black, BS, Tonks, I, Tran, H, Trapin, L, Trolle, AB, Vaduva, M, Valente, G, Van Ness, RA, Vasquez, A, Verousis, T, Verwijmeren, P, Bohorquez, S, Vilhelmsson, A, Vilkov, G, Vladimirov, V, Vogel, S, Voigt, S, Wagner, W, Walther, T, Weiss, P, van der Wel, M, Werner, IM, Bondarenko, O, Westerholm, PJ, Westheide, C, Wipplinger, E, Wolf, M, Wolff, CCP, Wolk, L, Wong, WK, Wrampelmeyer, J, Wu, Z-X, Xia, S, Bos, CS, Xiu, D, Xu, K, Xu, C, Yadav, PK, Yagüe, J, Yan, C, Yang, A, Yoo, W, Yu, W, Yu, S, Bosch-Rosa, C, Yueshen, BZ, Yuferova, D, Zamojski, M, Zareei, A, Zeisberger, S, Zhang, S, Zhang, X, Zhong, Z, Zhou, ZI, Zhou, C, Bouri, E, Zhu, X, Zoican, M, Zwinkels, RCJ, Chen, J, Duevski, T, Gao, G, Gemayel, R, Gilder, D, Kuhle, P, Pagnotta, E, Brownlees, CT, Pelli, M, Sönksen, J, Zhang, L, Ilczuk, K, Bogoev, D, Qian, Y, Wika, HC, Yu, Y, Zhao, L, Mi, M, Calamia, A, Bao, L, Cao, VN, Capelle-Blancard, G, Capera, L, Caporin, M, Carrion, A, Caskurlu, T, Chakrabarty, B, Chernov, M, Cheung, WMY, Chincarini, LB, Chordia, T, Chow, SC, Clapham, B, Colliard, J-E, Comerton-Forde, C, Curran, E, Dao, T, Dare, W, Davies, RJ, De Blasis, R, De Nard, G, Declerck, F, Deev, O, Degryse, H, Deku, S, Desagre, C, Van Dijk, MA, Dim, C, Dimpfl, T, Dong, YJ, Drummond, P, Dudda, T, Dumitrescu, A, Dyakov, T, Dyhrberg, AH, Dzieliński, M, Eksi, A, El Kalak, I, ter Ellen, S, Eugster, N, Evans, MDD, Farrell, M, Félez-Viñas, E, Ferrara, G, FERROUHI, EM, Flori, A, Fluharty-Jaidee, J, Foley, S, Fong, KYL, Foucault, T, Franus, T, Franzoni, FA, Frijns, B, Frömmel, M, Fu, S, Füllbrunn, S, Gan, B, Gehrig, T, Gerritsen, D, Gil-Bazo, J, Glosten, LR, Gomez, T, Gorbenko, A, Güçbilmez, U, Grammig, J, Menkveld, AJ, Dreber, A, Holzmeister, F, Huber, J, Johanneson, M, Kirchler, M, Razen, M, Weitzel, U, Abad, D, Abudy, MM, Adrian, T, Gregoire, V, Hagströmer, B, Hambuckers, J, Hapnes, E, Harris, JH, Harris, L, Hartmann, S, Hasse, J-B, Hautsch, N, He, X-ZT, Ait-Sahalia, Y, Heath, D, Hediger, S, Hendershott, TJ, Hibbert, AM, Hjalmarsson, E, Hoelscher, S, Hoffmann, P, Holden, CW, Horenstein, AR, Huang, W, Akmansoy, O, Huang, D, Hurlin, C, Ivashchenko, A, Iyer, SR, Jahanshahloo, H, Jalkh, N, Jones, CM, Jurkatis, S, Jylha, P, Kaeck, A, Alcock, J, Kaiser, G, Karam, A, Karmaziene, E, Kassner, B, Kaustia, M, Kazak, E, Kearney, F, van Kervel, V, Khan, S, Khomyn, M, Alexeev, V, Klein, T, Klein, O, Klos, A, Koetter, M, Krahnen, JP, Kolokolov, A, Korajczyk, RA, Kozhan, R, Kwan, A, Lajaunie, Q, Aloosh, A, Lam, FYEC, Lambert, M, Langlois, H, Lausen, J, Lauter, T, Leippold, M, Levin, V, Li, Y, Li, MH, Liew, CY, Amato, L, Lindner, T, Linton, OB, Liu, J, Liu, A, Llorente-Alvarez, J-G, Lof, M, Lohr, A, Longstaff, FA, Lopez-Lira, A, Mankad, S, Amaya, D, Mano, N, Marchal, A, Martineau, C, Mazzola, F, Meloso, DC, Mihet, R, Mohan, V, Moinas, S, Moore, D, Mu, L, Angel, JJ, Muravyev, D, Murphy, D, Neszveda, G, Neumeier, C, Nielsson, U, Nimalendran, M, Nolte, S, Nordén, LL, O'Neill, P, Obaid, K, Bach, A, Ødegaard, BA, Östberg, P, Painter, M, Palan, S, Palit, I, Park, A, Pascual Gascó, R, Pasquariello, P, Pastor, L, Patel, V, Baidoo, E, Patton, AJ, Pearson, ND, Pelizzon, L, Pelster, M, Pérignon, C, Pfiffer, C, Philip, R, Plíhal, T, Prakash, P, Press, O-A, Bakalli, G, Prodromou, T, Putnins, TJ, Raizada, G, Rakowski, DA, Ranaldo, A, Regis, L, Reitz, S, Renault, T, Wang, R, Renò, R, Barbon, A, Riddiough, S, Rinne, K, Rintamäki, P, Riordan, R, RITTMANNSBERGER, T, Rodríguez Longarela, I, Rösch, D, Rognone, L, Roseman, B, Rosu, I, Bashchenko, O, Roy, S, Rudolf, N, Rush, S, Rzayev, K, Rzeźnik, A, Sanford, A, Sankaran, H, Sarkar, A, Sarno, L, Scaillet, O, Bindra, PC, Scharnowski, S, Schenk-Hoppé, KR, Schertler, A, Schneider, M, Schroeder, F, Schürhoff, N, Schuster, P, Schwarz, MA, Seasholes, MS, Seeger, N, Bjonnes, GH, Shachar, O, Shkilko, A, Shui, J, Sikic, M, Simion, G, Smales, LA, Söderlind, P, Sojli, E, Sokolov, K, Spokeviciute, L, Black, JR, Stefanova, D, Subrahmanyam, MG, Neusüss, S, Szaszi, B, Talavera, O, Tang, Y, Taylor, N, Tham, WW, Theissen, E, Thimme, J, Black, BS, Tonks, I, Tran, H, Trapin, L, Trolle, AB, Vaduva, M, Valente, G, Van Ness, RA, Vasquez, A, Verousis, T, Verwijmeren, P, Bohorquez, S, Vilhelmsson, A, Vilkov, G, Vladimirov, V, Vogel, S, Voigt, S, Wagner, W, Walther, T, Weiss, P, van der Wel, M, Werner, IM, Bondarenko, O, Westerholm, PJ, Westheide, C, Wipplinger, E, Wolf, M, Wolff, CCP, Wolk, L, Wong, WK, Wrampelmeyer, J, Wu, Z-X, Xia, S, Bos, CS, Xiu, D, Xu, K, Xu, C, Yadav, PK, Yagüe, J, Yan, C, Yang, A, Yoo, W, Yu, W, Yu, S, Bosch-Rosa, C, Yueshen, BZ, Yuferova, D, Zamojski, M, Zareei, A, Zeisberger, S, Zhang, S, Zhang, X, Zhong, Z, Zhou, ZI, Zhou, C, Bouri, E, Zhu, X, Zoican, M, Zwinkels, RCJ, Chen, J, Duevski, T, Gao, G, Gemayel, R, Gilder, D, Kuhle, P, Pagnotta, E, Brownlees, CT, Pelli, M, Sönksen, J, Zhang, L, Ilczuk, K, Bogoev, D, Qian, Y, Wika, HC, Yu, Y, Zhao, L, Mi, M, Calamia, A, Bao, L, Cao, VN, Capelle-Blancard, G, Capera, L, Caporin, M, Carrion, A, Caskurlu, T, Chakrabarty, B, Chernov, M, Cheung, WMY, Chincarini, LB, Chordia, T, Chow, SC, Clapham, B, Colliard, J-E, Comerton-Forde, C, Curran, E, Dao, T, Dare, W, Davies, RJ, De Blasis, R, De Nard, G, Declerck, F, Deev, O, Degryse, H, Deku, S, Desagre, C, Van Dijk, MA, Dim, C, Dimpfl, T, Dong, YJ, Drummond, P, Dudda, T, Dumitrescu, A, Dyakov, T, Dyhrberg, AH, Dzieliński, M, Eksi, A, El Kalak, I, ter Ellen, S, Eugster, N, Evans, MDD, Farrell, M, Félez-Viñas, E, Ferrara, G, FERROUHI, EM, Flori, A, Fluharty-Jaidee, J, Foley, S, Fong, KYL, Foucault, T, Franus, T, Franzoni, FA, Frijns, B, Frömmel, M, Fu, S, Füllbrunn, S, Gan, B, Gehrig, T, Gerritsen, D, Gil-Bazo, J, Glosten, LR, Gomez, T, Gorbenko, A, Güçbilmez, U, and Grammig, J

Published
2024

37. PGAP2-Related Hyperphosphatasia-Mental Retardation Syndrome: Report of a Novel Patient, Toward a Broadening of Phenotypic Spectrum and Therapeutic Perspectives

Author

Saracino, Annalisa, additional, Totaro, Martina, additional, Politano, Davide, additional, DE Giorgis, Valentina, additional, Gana, Simone, additional, Papalia, Grazia, additional, Pichiecchio, Anna, additional, Plumari, Massimo, additional, Rognone, Elisa, additional, Varesio, Costanza, additional, and Orcesi, Simona, additional

Published
2024
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38. Cerebellar heterotopia in an 11‐year‐old child with KDM6B‐related neurodevelopmental disorder: A case report and review of the literature.

Author

Politano, Davide, D'Abrusco, Fulvio, Pasca, Ludovica, Ferraro, Francesca, Gana, Simone, Garau, Jessica, Zanaboni, Martina Paola, Rognone, Elisa, Pichiecchio, Anna, Borgatti, Renato, Valente, Enza Maria, De Giorgis, Valentina, and Romaniello, Romina

Abstract

Heterozygous pathogenic variants in KDM6B have recently been associated to a rare neurodevelopmental disorder referred to as "Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities" and characterized by non‐pathognomonic facial and body dysmorphisms, a wide range of neurodevelopmental and behavioral disorders and nonspecific neuroradiological findings. KDM6B encodes a histone demethylase, expressed in different tissues during development, which regulates gene expression through the modulation of chromatin accessibility by RNA polymerase. We herein describe a 11‐year‐old male patient carrying a novel de novo pathogenic variant in KDM6B exhibiting facial dysmorphisms, dysgraphia, behavioral traits relatable to oppositional defiant, autism spectrum, and attention deficit hyperactivity disorders, a single seizure episode, and a neuroimaging finding of a single cerebellar heterotopic nodule, never described to date in this genetic condition. These findings expand the phenotypic spectrum of this syndrome, highlighting the potential role for KDM6B in cerebellar development and providing valuable insights for genetic counseling. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Novel HYLS1variants associated with Joubert syndrome suggest potential genotype-phenotype correlates

Author

Gana, Simone, D’Abrusco, Fulvio, Nicotra, Roberta, Ghiberti, Chiara, Catalano, Guido, Rognone, Elisa, Pichiecchio, Anna, Signorini, Sabrina, and Valente, Enza Maria

Abstract

Joubert syndrome (JS) is an inherited neurodevelopmental ciliopathy with wide clinical and genetic heterogeneity, whose paradigmatic sign is a peculiar cerebellar and brainstem malformation known as the ‘molar tooth sign’. Recessive pathogenic variants in the HYLS1gene are associated with hydrolethalus syndrome (HLS), a severe disorder characterised by multiple developmental defects leading to intrauterine or perinatal death. However, HYLS1biallelic variants were also reported in three individuals with JS.Here, we report a fourth patient with a purely neurological JS carrying two compound heterozygous missense variants in the HYLS1gene. Notably, while all patients with lethal HLS had both variants falling within the highly conserved HYLS-1 Box, the four patients with milder JS phenotype featured at least one variant external to this evolutionary conserved domain, suggesting a possible correlation between the mutation site and the severity of the phenotype.

Published
2025
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41. Optimizing the mitigation of epidemic spreading through targeted adoption of contact tracing apps

Author

Aleix Bassolas, Andrea Santoro, Sandro Sousa, Silvia Rognone, and Vincenzo Nicosia

Subjects
Physics, QC1-999
Abstract

The ongoing COVID-19 pandemic is the first epidemic in human history in which digital contact tracing has been deployed at a global scale. Tracking and quarantining all the contacts of individuals who test positive for a virus can help slow down an epidemic, but the impact of contact tracing is severely limited by the generally low adoption of contact-tracing apps in the population. We derive here an analytical expression for the effectiveness of contact-tracing app installation strategies in a susceptible-infected-recovered (SIR) model on a given contact graph. We propose a decentralized heuristic to improve the effectiveness of contact tracing under fixed adoption rates, which targets a set of individuals to install contact-tracing apps and can be easily implemented. Simulations on a large number of real-world contact networks confirm that this heuristic represents a feasible alternative to the current state of the art.

Published
2022
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43. Expanding the Natural History of SNORD118-Related Ribosomopathy: Hints from an Early-Diagnosed Patient with Leukoencephalopathy with Calcifications and Cysts and Overview of the Literature

Author

Politano, Davide, primary, Catalano, Guido, additional, Pezzotti, Elena, additional, Varesio, Costanza, additional, Sirchia, Fabio, additional, Casella, Antonella, additional, Rognone, Elisa, additional, Pichiecchio, Anna, additional, Borgatti, Renato, additional, and Orcesi, Simona, additional

Published
2023
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46. Vessel Wall Magnetic Resonance Imaging in Cerebrovascular Diseases

Author

Federico Mazzacane, Valentina Mazzoleni, Elisa Scola, Sara Mancini, Ivano Lombardo, Giorgio Busto, Elisa Rognone, Anna Pichiecchio, Alessandro Padovani, Andrea Morotti, and Enrico Fainardi

Subjects
cerebrovascular disease, vessel wall MRI, intracranial vasculopathy, stroke, atherosclerosis, vasculitis, Medicine (General), R5-920
Abstract

Cerebrovascular diseases are a leading cause of disability and death worldwide. The definition of stroke etiology is mandatory to predict outcome and guide therapeutic decisions. The diagnosis of pathological processes involving intracranial arteries is especially challenging, and the visualization of intracranial arteries’ vessel walls is not possible with routine imaging techniques. Vessel wall magnetic resonance imaging (VW-MRI) uses high-resolution, multiparametric MRI sequences to directly visualize intracranial arteries walls and their pathological alterations, allowing a better characterization of their pathology. VW-MRI demonstrated a wide range of clinical applications in acute cerebrovascular disease. Above all, it can be of great utility in the differential diagnosis of atherosclerotic and non-atherosclerotic intracranial vasculopathies. Additionally, it can be useful in the risk stratification of intracranial atherosclerotic lesions and to assess the risk of rupture of intracranial aneurysms. Recent advances in MRI technology made it more available, but larger studies are still needed to maximize its use in daily clinical practice.

Published
2022
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47. Management of Trastuzumab Deruxtecan-related nausea and vomiting in real-world practice.

Author

Notini, Giulia, Naldini, Matteo Maria, Sica, Lorenzo, Viale, Giulia, Rognone, Alessia, Zambelli, Stefania, Zucchinelli, Patrizia, Piras, Marta, Bosi, Carlo, Mariani, Marco, Aldrighetti, Daniela, Bianchini, Giampaolo, and Licata, Luca

Subjects
NAUSEA, TRASTUZUMAB, VOMITING, METASTATIC breast cancer, PHYSICIANS
Abstract

Background: Nausea and vomiting are common side effects of Trastuzumab Deruxtecan (T-DXd), but guidelines for optimal management were not initially available. This retrospective single-center study aimed at evaluating the efficacy of two antiemetic regimens in patients receiving T-DXd. Methods: Data from metastatic breast cancer patients receiving T-DXd were collected. Two groups were defined: patients treated with 5-HT3 receptor antagonists (RA) ± dexamethasone (5-HT3-group) and patients treated with a fixed oral combination of netupitant (NK1RA) and palonosetron ± dexamethasone (NK1 group). Physicians preferentially offered the NK1 regimen to patients at higher risk of nausea and vomiting based on internal recommendations. Only nausea and vomiting during cycles 1 and 2 were considered. Comparisons of nausea and vomiting by the antiemetic prophylaxis group were assessed using chi-square. Results: A total of 53 patients were included in the analysis. At cycle 1, 72% and 28% of patients received the 5-HT3 and NK1 prophylaxis, respectively. Overall, 58% reported nausea, with no differences between groups (58% vs. 60%; p=0.832), but with a trend for lower grade in the NK1 group (33.3% G1; 26.7% G2) compared to the 5-HT3 group (23.7% G1; 31.6% G2; 2.6% G3). Vomiting was reported by 21% and 0% of patients in the 5-HT3 and the NK1 group, respectively (p=0.054). Among the 15 patients in the 5-HT3 group with nausea at cycle 1 who escalated to NK1 at cycle 2, nausea decreased from 100% to 53% (p=0.022) and vomiting decreased from 47% to 13% (p=0.046). Conclusions: The NK1 regimen improved vomiting control at cycle 1 and, when introduced at cycle 2, significantly improved both nausea and vomiting. The biased NK1 selection for higher-risk patients may have dampened the differences between groups at cycle 1. These findings support enhanced control of T-DXdrelated nausea and vomiting with NK1RA. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Retrospective Analysis of the Correlation of MSI-h/dMMR Status and Response to Therapy for Endometrial Cancer: RAME Study, a Multicenter Experience

Author

Tuninetti, Valentina, primary, Pace, Luca, additional, Ghisoni, Eleonora, additional, Quarà, Virginia, additional, Arezzo, Francesca, additional, Palicelli, Andrea, additional, Mandato, Vincenzo Dario, additional, Geuna, Elena, additional, Cormio, Gennaro, additional, Biglia, Nicoletta, additional, Borsotti, Lucia, additional, Gallo, Silvia, additional, Ferrero, Annamaria, additional, Jacomuzzi, Elena, additional, Fuso, Luca, additional, Pezua Sanjinez, Jeremy Oscar Smith, additional, Puppo, Andrea, additional, Caglio, Andrea, additional, Rognone, Chiara, additional, Turinetto, Margherita, additional, Scotto, Giulia, additional, Di Maio, Massimo, additional, and Valabrega, Giorgio, additional

Published
2023
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50. Non-Standard Errors

Author

Menkveld, A.J., Dreber, A., Holzmeister, F., Huber, J., Johannesson, M., Kirchler, M., Razen, M., Weitzel, G.U., Abad, D., Abudy, M., Adrian, T., Ait-Sahalia, Y., Akmansoy, O., Alcock, J., Alexeev, V., Aloosh, A., Amato, L., Amaya, D., Angel, J., Bach, A., Baidoo, E., Bakalli, G., Barbon, A., Bashchenko, O., Bindra, P.C., Bjonnes, G.H., Black, J., Black, B.S., Bohorquez, S., Bondarenko, O., Bos, C.S., Bosch-Rosa, C., Bouri, E., Brownlees, C.T., Calamia, A., Cao, V.N., Capelle-Blancard, G., Capera, L., Caporin, M., Carrion, A., Caskurlu, T., Chakrabarty, B., Chernov, M., Cheung, W.M., Chincarini, L.B., Chordia, T., Chow, S.C., Clapham, B., Colliard, J.-E., Comerton-Forde, C., Curran, E., Dao, T., Dare, W., Davies, R.J., Blasis, R. De, Nard, G. De, DeClerck, F., Deev, O., Degryse, H., Deku, S., Desagre, C., Dijk, M.A van, Dim, C., Dimpfl, T., Dong, Y., Drummond, P., Dudda, T., Dumitrescu, A., Dyakov, T., Dyhrberg, A.H., Dzieliński, M., Eksi, A., Kalak, I. El, Ellen, S. ter, Eugster, N., Evans, M.D.D., Farrell, M., Félez-Viñas, E., Ferrara, G., Ferrouhi, E.M., Flori, A., Fluharty-Jaidee, J., Foley, S., Fong, K.Y.L., Foucault, T., Franus, T., Franzoni, F.A., Frijns, B., Frömmel, M., Fu, S., Füllbrunn, S.C., Gan, B., Gehrig, T., Gerritsen, D., Gil-Bazo, J., Glosten, L.R., Gomez, T., Gorbenko, A., Güçbilmez, U., Grammig, J., Gregoire, V., Hagströmer, B., Hambuckers, J., Hapnes, E., Harris, J.H., Harris, L., Hartmann, S., Hasse, J.-B., Hautsch, N., He, X., Heath, D., Hediger, S., Hendershott, T., Hibbert, A.M., Hjalmarsson, E., Hoelscher, S.A., Hoffmann, P., Holden, C.W., Horenstein, A.R., Huang, W., Huang, D., Hurlin, C., Ivashchenko, A., Iyer, S.R., Jahanshahloo, H., Jalkh, N., Jones, C.M., Jurkatis, S., Jylha, P., Kaeck, A., Kaiser, G., Karam, A., Karmaziene, E., Kassner, B., Kaustia, M., Kazak, E., Kearney, F., Kervel, V. van, Khan, S., Khomyn, M., Klein, T., Klein, O., Klos, A., Koetter, M., Krahnen, J.P., Kolokolov, A., Korajczyk, R.A., Kozhan, R., Kwan, A., Lajaunie, Q., Lam, F.E.C., Lambert, M., Langlois, H., Lausen, J., Lauter, T., Leippold, M., Levin, V., Li, Y., Li, H., Liew, C.Y., Lindner, T., Linton, O.B., Liu, J., Liu, A., Llorente, G., Lof, M., Lohr, A., Longstaff, F.A., Lopez-Lira, A., Mankad, S., Mano, N., Marchal, A., Martineau, C., Mazzola, F., Meloso, D., Mihet, R., Mohan, V., Moinas, S., Moore, D., Mu, L., Muravyev, D., Murphy, D., Neszveda, G., Neumeier, C., Nielsson, U., Nimalendran, M., Nolte, S., Norden, L.L., O'Neill, P., Obaid, K., Ødegaard, B.A., Östberg, P., Painter, M., Palan, S., Palit, I., Park, A., Pascual, R., Pasquariello, P., Pastor, L., Patel, V., Patton, A.J., Pearson, N.D., Pelizzon, L., Pelster, M., Pérignon, C., Pfiffer, C., Philip, R., Plíhal, T., Prakash, P., Press, O.-A., Prodromou, T., Putniņš, T.J., Raizada, G., Rakowski, D.A., Ranaldo, A., Regis, L., Reitz, S., Renault, T., Renjie, R.W., Renò, R., Riddiough, S., Rinne, K., Rintamäki, P., Riordan, R., Rittmannsberger, T., Rodríguez-Longarela, I., Rösch, D., Rognone, L., Roseman, B., Rosu, I., Roy, S., Rudolf, N., Rush, S., Rzayev, K., Rzeźnik, A., Sanford, A., Sankaran, H., Sarkar, A., Sarno, L., Scaillet, O., Scharnowski, S., Schenk-Hoppé, K.R., Schertler, A., Schneider, M., Schroeder, F., Schürhoff, N., Schuster, P., Schwarz, M.A., Seasholes, M.S., Seeger, N., Shachar, O., Shkilko, A., Shui, J., Sikic, M., Simion, G., Smales, L.A., Söderlind, P., Sojli, E., Sokolov, K., Spokeviciute, L., Stefanova, D., Subrahmanyam, M.G., Neusüss, S., Szaszi, B., Talavera, O., Tang, Y., Taylor, N., Tham, W.W., Theissen, E., Thimme, J., Tonks, I., Tran, H., Trapin, L., Trolle, A.B., Valente, G., Ness, R.A. Van, Vasquez, A., Verousis, T., Verwijmeren, P., Vilhelmsson, A., Vilkov, G., Vladimirov, V., Vogel, S., Voigt, S., Wagner, W., Walther, T., Weiss, P., Wel, M. van der, Werner, I.M., Westerholm, P.J., Westheide, C., Wipplinger, E., Wolf, M., Wolff, C.C.P., Wolk, L., Wong, W.-K., Wrampelmeyer, J., Xia, S., Xiu, D., Xu, K., Xu, C., Yadav, P.K., Yagüe, J., Yan, C., Yang, A., Yoo, W., Yu, W., Yu, S., Yueshen, B.Z., Yuferova, D., Zamojski, M., Zareei, A., Zeisberger, S.M., Zhang, S.S., Zhang, X., Zhong, Z., Zhou, Z.I., Zhou, C., Zhu, X.S., Zoican, M., Zwinkels, R.C.J., Chen, J., Duevski, T., Gao, G., Gemayel, R., Gilder, D. de, Kuhle, P., Pagnotta, E., Pelli, M., Sönksen, J., Zhang, L., Ilczuk, K., Bogoev, D., Qian, Y., Wika, H.C., Yu, Y., Zhao, L., Mi, M., Bao, L., Vaduva, A., Prokopczuk, P., Avetikian, A., Wu, Z.-X., Menkveld, A.J., Dreber, A., Holzmeister, F., Huber, J., Johannesson, M., Kirchler, M., Razen, M., Weitzel, G.U., Abad, D., Abudy, M., Adrian, T., Ait-Sahalia, Y., Akmansoy, O., Alcock, J., Alexeev, V., Aloosh, A., Amato, L., Amaya, D., Angel, J., Bach, A., Baidoo, E., Bakalli, G., Barbon, A., Bashchenko, O., Bindra, P.C., Bjonnes, G.H., Black, J., Black, B.S., Bohorquez, S., Bondarenko, O., Bos, C.S., Bosch-Rosa, C., Bouri, E., Brownlees, C.T., Calamia, A., Cao, V.N., Capelle-Blancard, G., Capera, L., Caporin, M., Carrion, A., Caskurlu, T., Chakrabarty, B., Chernov, M., Cheung, W.M., Chincarini, L.B., Chordia, T., Chow, S.C., Clapham, B., Colliard, J.-E., Comerton-Forde, C., Curran, E., Dao, T., Dare, W., Davies, R.J., Blasis, R. De, Nard, G. De, DeClerck, F., Deev, O., Degryse, H., Deku, S., Desagre, C., Dijk, M.A van, Dim, C., Dimpfl, T., Dong, Y., Drummond, P., Dudda, T., Dumitrescu, A., Dyakov, T., Dyhrberg, A.H., Dzieliński, M., Eksi, A., Kalak, I. El, Ellen, S. ter, Eugster, N., Evans, M.D.D., Farrell, M., Félez-Viñas, E., Ferrara, G., Ferrouhi, E.M., Flori, A., Fluharty-Jaidee, J., Foley, S., Fong, K.Y.L., Foucault, T., Franus, T., Franzoni, F.A., Frijns, B., Frömmel, M., Fu, S., Füllbrunn, S.C., Gan, B., Gehrig, T., Gerritsen, D., Gil-Bazo, J., Glosten, L.R., Gomez, T., Gorbenko, A., Güçbilmez, U., Grammig, J., Gregoire, V., Hagströmer, B., Hambuckers, J., Hapnes, E., Harris, J.H., Harris, L., Hartmann, S., Hasse, J.-B., Hautsch, N., He, X., Heath, D., Hediger, S., Hendershott, T., Hibbert, A.M., Hjalmarsson, E., Hoelscher, S.A., Hoffmann, P., Holden, C.W., Horenstein, A.R., Huang, W., Huang, D., Hurlin, C., Ivashchenko, A., Iyer, S.R., Jahanshahloo, H., Jalkh, N., Jones, C.M., Jurkatis, S., Jylha, P., Kaeck, A., Kaiser, G., Karam, A., Karmaziene, E., Kassner, B., Kaustia, M., Kazak, E., Kearney, F., Kervel, V. van, Khan, S., Khomyn, M., Klein, T., Klein, O., Klos, A., Koetter, M., Krahnen, J.P., Kolokolov, A., Korajczyk, R.A., Kozhan, R., Kwan, A., Lajaunie, Q., Lam, F.E.C., Lambert, M., Langlois, H., Lausen, J., Lauter, T., Leippold, M., Levin, V., Li, Y., Li, H., Liew, C.Y., Lindner, T., Linton, O.B., Liu, J., Liu, A., Llorente, G., Lof, M., Lohr, A., Longstaff, F.A., Lopez-Lira, A., Mankad, S., Mano, N., Marchal, A., Martineau, C., Mazzola, F., Meloso, D., Mihet, R., Mohan, V., Moinas, S., Moore, D., Mu, L., Muravyev, D., Murphy, D., Neszveda, G., Neumeier, C., Nielsson, U., Nimalendran, M., Nolte, S., Norden, L.L., O'Neill, P., Obaid, K., Ødegaard, B.A., Östberg, P., Painter, M., Palan, S., Palit, I., Park, A., Pascual, R., Pasquariello, P., Pastor, L., Patel, V., Patton, A.J., Pearson, N.D., Pelizzon, L., Pelster, M., Pérignon, C., Pfiffer, C., Philip, R., Plíhal, T., Prakash, P., Press, O.-A., Prodromou, T., Putniņš, T.J., Raizada, G., Rakowski, D.A., Ranaldo, A., Regis, L., Reitz, S., Renault, T., Renjie, R.W., Renò, R., Riddiough, S., Rinne, K., Rintamäki, P., Riordan, R., Rittmannsberger, T., Rodríguez-Longarela, I., Rösch, D., Rognone, L., Roseman, B., Rosu, I., Roy, S., Rudolf, N., Rush, S., Rzayev, K., Rzeźnik, A., Sanford, A., Sankaran, H., Sarkar, A., Sarno, L., Scaillet, O., Scharnowski, S., Schenk-Hoppé, K.R., Schertler, A., Schneider, M., Schroeder, F., Schürhoff, N., Schuster, P., Schwarz, M.A., Seasholes, M.S., Seeger, N., Shachar, O., Shkilko, A., Shui, J., Sikic, M., Simion, G., Smales, L.A., Söderlind, P., Sojli, E., Sokolov, K., Spokeviciute, L., Stefanova, D., Subrahmanyam, M.G., Neusüss, S., Szaszi, B., Talavera, O., Tang, Y., Taylor, N., Tham, W.W., Theissen, E., Thimme, J., Tonks, I., Tran, H., Trapin, L., Trolle, A.B., Valente, G., Ness, R.A. Van, Vasquez, A., Verousis, T., Verwijmeren, P., Vilhelmsson, A., Vilkov, G., Vladimirov, V., Vogel, S., Voigt, S., Wagner, W., Walther, T., Weiss, P., Wel, M. van der, Werner, I.M., Westerholm, P.J., Westheide, C., Wipplinger, E., Wolf, M., Wolff, C.C.P., Wolk, L., Wong, W.-K., Wrampelmeyer, J., Xia, S., Xiu, D., Xu, K., Xu, C., Yadav, P.K., Yagüe, J., Yan, C., Yang, A., Yoo, W., Yu, W., Yu, S., Yueshen, B.Z., Yuferova, D., Zamojski, M., Zareei, A., Zeisberger, S.M., Zhang, S.S., Zhang, X., Zhong, Z., Zhou, Z.I., Zhou, C., Zhu, X.S., Zoican, M., Zwinkels, R.C.J., Chen, J., Duevski, T., Gao, G., Gemayel, R., Gilder, D. de, Kuhle, P., Pagnotta, E., Pelli, M., Sönksen, J., Zhang, L., Ilczuk, K., Bogoev, D., Qian, Y., Wika, H.C., Yu, Y., Zhao, L., Mi, M., Bao, L., Vaduva, A., Prokopczuk, P., Avetikian, A., and Wu, Z.-X.

Abstract

31 mei 2023, Contains fulltext : 240328.pdf (Author’s version preprint ) (Open Access), In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in sample estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: non-standard errors. To study them, we let 164 teams test six hypotheses on the same sample. We find that non-standard errors are sizeable, on par with standard errors. Their size (i) co-varies only weakly with team merits, reproducibility, or peer rating, (ii) declines significantly after peer-feedback, and (iii) is underestimated by participants.

Published
2023

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