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3. EEG in fitness to drive evaluations in people with epilepsy — Considerable variations across Europe

Author

Markhus, Rune, Henning, Oliver, Molteberg, Ellen, Hećimović, Hrvoje, Ujvari, Akos, Hirsch, Edouard, Rheims, Sylvain, Surges, Rainer, Malmgren, Kristina, Rüegg, Stephan, Gil-Nagel, Antonio, Roivainen, Reina, Picard, Fabienne, Steinhoff, Bernhard, Marusic, Petr, Mostacci, Barbara, Kimiskidis, Vasilios K., Mindruta, Ioana, Jagella, Caroline, Mameniškienė, Rūta, Schulze-Bonhage, Andreas, Rosenow, Felix, Kelemen, Anna, Fabo, Daniel, Walker, Matthew C., Seeck, Margitta, Krämer, Günter, Arsene, Oana Tarta, Krestel, Heinz, and Lossius, Morten

Published
2020
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4. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

Author

Faravelli, Francesca, Pantaleoni, Chiara, Robert-Gnansia, Elisabeth, Cabral-Lim, Leonor, Čebular, Boštjan, De Marinis, Alejandro, Kälviäinen, Reetta, Khomeriki, Ketevan, Kiteva-Trencevska, Gordana, Kochen, Silvia, Kurthen, Martin, Luef, Gerhard, Martinez Ferri, Meritxell, Milovanović, Maja, Nakken, Karl Otto, Neufeld, Miri, Ohtani, Hideyuki, Russell, Aline, Safcák, Vladimír, Schmitz, Bettina, Specchio, Luigi Maria, Tettenborn, Barbara, van Puijenbroek, Eugene, Yu, Hsiang-Yu, Zarubova, Jana, Albretsen, Claus, Alvestad, Silje, Andersen, Noemi Becser, Antonini, Luisa, Arentsen, Jens, Aurlien, Dag, Barzinji, Ismael, Becerra Cuñat, Juan Luis, Bohorquez Morera, Natalia, Brodie, Martin J., Brodtkorb, Eylert, Broglio, Laura, Bruun Christensen, Elsebeth, Bušek, Petr, Cagnetti, Claudia, Canevini, Maria Paola, Carius, Astrid, Castro Vilanova, Maria Dolores, Cecconi, Michela, Chang, T-Y, Christensen, Jakob, De Maria, Giovanni, Dennig, Dieter, Diputado, Brenda, Ertresvåg, Janne Marit, Escartin, Toni, Flügel, Dominique, Forsom Sondal, Birgitte, Foschi, Nicoletta, Franza, Albertina, Fukushima, Katsuyuki, Gambardella, Antonio, Garamendi Ruiz, Iñigo, Gauffin, Helena, Gellert, Pia, Gjerstad, Leif, Gordon, Lisa, Haggag, Katrine, Halawa, Imad, Heikinheimo-Connell, Terttu, Hendgen, Tim, Hertz, Zarouhi, Hildenhagen, Odo, Hödl, Stephanie, Hogenesch, Ineke, Huuse Farmen, Anette, Inoue, Yushi, Juhl, Stefan, Kato, Masaaki, Kenou Van Rijckevorssel, Germaine, Kluck, E., Krijtová, Hana, Kumlien, Eva, Labate, Angelo, Lasch, Theresa, Lindsten, Hans, Listonova, Renata, Lossius, Rasmus, Lundgren, Anders, Malmgren, Kristina, Marečková, Iva, Marino, Daniela, Mattsson, Peter, McGonigal, Aileen, Miesczanleh, Katarzyna, Mizobuchi, Masahiro, Mostacci, Barbara, Müffelmann, Birgit, Navn, Uden, Nilsson, Anders, Oehl, Bernhard, Ortenzi, Andrea, Osseforth, Judith, Paggi, Aldo, Pastor, Eliana, Pedersen, Birthe, Petrenaite, Vaiva, Pignatta, Pietro, Pires, Isabel, Pistelli, Alessandra, Riuz Gimenez, Jesús Antonio, Rocchi, Raffaele, Rodam, Lone, Roivainen, Reina, Rytířová, Gisela, Samsonsen, Christian, Sansa Fayos, Gemma, Saukkonen, Anna Maija, Sikiric, Alma, Sopelana Garay, David, Steinhoff, Bernhard, Strandberg, Maria, Svendsen, Torleiv, Tauboll, Erik, Terada, Kiyohito, Trivisano, Marina, Turner, Katherine, Worm, Mogens, Zakharia, Elias, Zambrelli, Elena, Zarifi-Oskoie, Morteza, Tomson, Torbjörn, Battino, Dina, Bonizzoni, Erminio, Craig, John, Lindhout, Dick, Perucca, Emilio, Sabers, Anne, Thomas, Sanjeev V, and Vajda, Frank

Published
2018
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6. Vagushermon stimulaation monet mahdollisuudet

Author

Roivainen, Reina, Neurotieteiden osasto, HUS Neurokeskus, and Neurologian yksikkö

Subjects
Inflammation, Central Nervous System, Depressive Disorder, Epilepsy, Vagus Nerve Stimulation, +therapy, Migraine Disorders, Cluster Headache, Inflammation Mediators, 3112 Neurotieteet, Obesity, Morbid, 3124 Neurologia ja psykiatria
Abstract

Vertaisarvioitu. Kiertäjä- eli vagushermon stimulaatio (VNS) on ollut käytössä vaikean epilepsian liitännäishoitona 25 vuoden ajan. Hyväksytyt käyttöaiheet laajenivat aluksi vaikean masennuksen hoitoon ja kajoamattoman VNS-hoitomuodon kehittämisen myötä sarjoittaisen päänsäryn sekä migreenikohtausten hoitoon. VNS:ää käytetään nykyisin yli 100 000 vaikeaa epilepsiaa sairastavan potilaan hoidossa. Käyttö muihin aiheisiin on toistaiseksi jäänyt melko vähäiseksi sekä teknisten haasteiden että osin vaikutuksen ja näytönasteen heikkouden takia. VNS on toistaiseksi otettu käyttöön sellaisten sairauksien hoidossa, joiden hoitovaste oletettavasti perustuu keskushermostovaikutuksiin. Vagushermo välittää kuitenkin myös tulehdusreaktiota hillitseviä signaaleja keskushermostosta kohde-elimiin. Hyvin erilaisista syistä aiheutuvien sairauksien VNS-hoitoa tutkitaan aktiivisesti, sillä hoidolla on useita mahdollisia vaikutustapoja.

Published
2022

9. Epilepsi och neurologens gamla versus nya verktygslåda

Author

Roivainen, Reina, Jonsson, Henna, Avdelningen för neurovetenskaper, HUS Neurocentrum, Neurologian yksikkö, Lastenneurologian yksikkö, and HUS Sjukvård för barn och unga

Subjects
3124 Neurologi och psykiatri, 3112 Neurovetenskaper
Abstract

English summary.

Published
2021

12. Epilepsiapotilas päivystyksessä

Author

Kämppi, Leena, Rainesalo, Sirpa, Roivainen, Reina, Neurologian yksikkö, HUS Neurokeskus, and Neurotieteiden osasto

Subjects
+drug therapy, Epilepsy, Status Epilepticus, Time Factors, After-Hours Care, +therapy, +diagnosis, Practice Guidelines as Topic, Comorbidity, +etiology, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

Vertaisarvioitu. English summary Epilepsiapotilaat ohjautuvat päivystykseen ensimmäisen, pitkittyneen, tiheästi toistuvan tai komplisoituneen kohtauksensa vuoksi. Nopea ja oikein kohdennettu hoito parhaassa tapauksessa estää kohtauksen vaikeutumisen status epilepticukseksi. Hoitoketjun eri vaiheiden saumaton eteneminen selkeän hoitoprotokollan mukaan on pitkittyneen epilepsiakohtauksen saaneen potilaan ennusteen kannalta keskeistä. Viiveettömän hoidon toteutuksen lisäksi lääkehoidon valinnassa tulisi huomioida epilepsian ja pitkittyneen kohtauksen tyyppi, etiologia ja niihin liittyvät epävarmuustekijät. Aikuispotilaiden osalta korostuvat liitännäissairaudet, niihin liittyvät hoidot ja kohtaustilanteen vaikeutumisen muut syyt. Vaikeassa kohtaustilanteessa epileptologisen yksikön konsultoiminen on tarpeen. Jos potilaan status epilepticus on vaikeahoitoinen, konsultaation tulisi toteutua kiireellisesti. Päivystyspisteiden osuus on merkittävä paitsi viiveettömässä kohtausten hoidossa myös jatkohoidon toteutuksessa ja ohjauksessa.

Published
2020

17. Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinases by a protein kinase C-dependent mechanism

Author

Roivainen, Reina, Hundle, Bhupinder, and Messing, Robert O.

Subjects
Protein kinases -- Physiological aspects, Growth factors -- Research, Alcohol -- Physiological aspects, Science and technology
Abstract

Analysis of the activation of mitogen-activated protein (MAP) kinases, a crucial step in growth factor signaling, shows that ethanol accelerates the nerve growth factor (NGF)- and basic fibroblast growth factor (bFGF)-induced activation of MAP kinases. Ethanol improves growth factor signal transmission via a delta or epsilon protein kinase C-regulated pathway, thereby promoting neurite growth.

Published
1995

21. Kannabis epilepsian lisälääkkeenä - onko näyttöä?

Author

Kalso, Eija, Roivainen, Reina, Eija Kalso / Vastuullinen tutkija, Diagnostis-terapeuttinen osasto, Clinicum, Helsingin yliopisto, Anestesiologian yksikkö, Neurotieteiden osasto, HUS Leikkaussalit, teho- ja kivunhoito, and HUS Neurokeskus

Subjects
+drug therapy, Drug Resistant Epilepsy, Epilepsy, Treatment Outcome, Seizures, Lennox Gastaut Syndrome, Cannabidiol, +therapeutic use, 3112 Neurotieteet, Endocannabinoids, 3124 Neurologia ja psykiatria
Published
2018

22. Dravet’n oireyhtymä - vaikea neurologinen harvinaissairaus

Author

Gaily, Eija, Roivainen, Reina, Clinicum, Lastenklinikka, Lastenneurologian yksikkö, Neurotieteiden osasto, Neurologian yksikkö, HUS Lasten ja nuorten sairaudet, and HUS Neurokeskus

Subjects
+drug therapy, Adult, Adolescent, +diagnosis, Developmental Disabilities, Motor Disorders, +genetics, Infant, Epilepsies, Myoclonic, Middle Aged, Spinal Curvatures, +epidemiology, Rare Diseases, 3123 Naisten- ja lastentaudit, Seizures, Child, Preschool, +prevention & control, Child, Cognition Disorders, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

Vertaisarvioitu Dravet’n oireyhtymä on harvinainen, mutta todennäköisesti alidiagnosoitu sairaus. Sen tavallisin syy on hermosolujen natriumkanavien toimintaa säätelevän SCN1A-geenin virhe. Sairaus alkaa infektioon, rokotukseen tai muuhun lämmönnousuun liittyvillä pitkittyneillä kuumekouristuksilla ensimmäisen ikävuoden aikana. Vaikea epilepsia on tunnetuin oire, mutta useimmilla on myös vaikeita kognitiivisia ja motorisia häiriöitä. Diagnoosilla on merkitystä, koska epilepsialääkkeiden oikealla valinnalla voidaan estää sarjakohtaukset ja lievittää oireita. Lapset tulee rokottaa normaalisti diagnoosista huolimatta.

Published
2018

23. Skitsofreniapotilaan etenevä kävelyvaikeus

Author

Ollila, Leena, Roivainen, Reina, Neurologian yksikkö, Clinicum, Neurotieteiden osasto, and HUS Neurokeskus

Subjects
3112 Neurotieteet, 3124 Neurologia ja psykiatria
Published
2018

24. Aikuispotilaiden epilepsian leikkaushoidon kehitysnäkymiä

Author

Roivainen, Reina, Lauronen, Leena, Gaily, Eija, Metsähonkala, Liisa, Peltola, Maria, Laakso, Aki, Neurotieteiden osasto, Clinicum, Neurologian yksikkö, HUS Neurokeskus, Kliinisen neurofysiologian yksikkö, Helsingin yliopisto, Diagnostis-terapeuttinen osasto, HUS Kuvantaminen, Lastenneurologian yksikkö, Lastenklinikka, HUS Lasten ja nuorten sairaudet, and Neurokirurgian yksikkö

Subjects
Adult, Risk, Epilepsy, GeneralLiterature_INTRODUCTORYANDSURVEY, +diagnosis, 3126 Kirurgia, anestesiologia, tehohoito, radiologia, Brain, Temporal Lobe, Treatment Outcome, Seizures, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, +prevention & control, +etiology, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), +surgery, 3112 Neurotieteet, 3124 Neurologia ja psykiatria
Abstract

English summary

Published
2018

25. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

Author

Tomson, Torbjörn, primary, Battino, Dina, additional, Bonizzoni, Erminio, additional, Craig, John, additional, Lindhout, Dick, additional, Perucca, Emilio, additional, Sabers, Anne, additional, Thomas, Sanjeev V, additional, Vajda, Frank, additional, Faravelli, Francesca, additional, Pantaleoni, Chiara, additional, Robert-Gnansia, Elisabeth, additional, Cabral-Lim, Leonor, additional, Čebular, Boštjan, additional, De Marinis, Alejandro, additional, Kälviäinen, Reetta, additional, Khomeriki, Ketevan, additional, Kiteva-Trencevska, Gordana, additional, Kochen, Silvia, additional, Kurthen, Martin, additional, Luef, Gerhard, additional, Martinez Ferri, Meritxell, additional, Milovanović, Maja, additional, Nakken, Karl Otto, additional, Neufeld, Miri, additional, Ohtani, Hideyuki, additional, Russell, Aline, additional, Safcák, Vladimír, additional, Schmitz, Bettina, additional, Specchio, Luigi Maria, additional, Tettenborn, Barbara, additional, van Puijenbroek, Eugene, additional, Yu, Hsiang-Yu, additional, Zarubova, Jana, additional, Albretsen, Claus, additional, Alvestad, Silje, additional, Andersen, Noemi Becser, additional, Antonini, Luisa, additional, Arentsen, Jens, additional, Aurlien, Dag, additional, Barzinji, Ismael, additional, Becerra Cuñat, Juan Luis, additional, Bohorquez Morera, Natalia, additional, Brodie, Martin J., additional, Brodtkorb, Eylert, additional, Broglio, Laura, additional, Bruun Christensen, Elsebeth, additional, Bušek, Petr, additional, Cagnetti, Claudia, additional, Canevini, Maria Paola, additional, Carius, Astrid, additional, Castro Vilanova, Maria Dolores, additional, Cecconi, Michela, additional, Chang, T-Y, additional, Christensen, Jakob, additional, De Maria, Giovanni, additional, Dennig, Dieter, additional, Diputado, Brenda, additional, Ertresvåg, Janne Marit, additional, Escartin, Toni, additional, Flügel, Dominique, additional, Forsom Sondal, Birgitte, additional, Foschi, Nicoletta, additional, Franza, Albertina, additional, Fukushima, Katsuyuki, additional, Gambardella, Antonio, additional, Garamendi Ruiz, Iñigo, additional, Gauffin, Helena, additional, Gellert, Pia, additional, Gjerstad, Leif, additional, Gordon, Lisa, additional, Haggag, Katrine, additional, Halawa, Imad, additional, Heikinheimo-Connell, Terttu, additional, Hendgen, Tim, additional, Hertz, Zarouhi, additional, Hildenhagen, Odo, additional, Hödl, Stephanie, additional, Hogenesch, Ineke, additional, Huuse Farmen, Anette, additional, Inoue, Yushi, additional, Juhl, Stefan, additional, Kato, Masaaki, additional, Kenou Van Rijckevorssel, Germaine, additional, Kluck, E., additional, Krijtová, Hana, additional, Kumlien, Eva, additional, Labate, Angelo, additional, Lasch, Theresa, additional, Lindsten, Hans, additional, Listonova, Renata, additional, Lossius, Rasmus, additional, Lundgren, Anders, additional, Malmgren, Kristina, additional, Marečková, Iva, additional, Marino, Daniela, additional, Mattsson, Peter, additional, McGonigal, Aileen, additional, Miesczanleh, Katarzyna, additional, Mizobuchi, Masahiro, additional, Mostacci, Barbara, additional, Müffelmann, Birgit, additional, Navn, Uden, additional, Nilsson, Anders, additional, Oehl, Bernhard, additional, Ortenzi, Andrea, additional, Osseforth, Judith, additional, Paggi, Aldo, additional, Pastor, Eliana, additional, Pedersen, Birthe, additional, Petrenaite, Vaiva, additional, Pignatta, Pietro, additional, Pires, Isabel, additional, Pistelli, Alessandra, additional, Riuz Gimenez, Jesús Antonio, additional, Rocchi, Raffaele, additional, Rodam, Lone, additional, Roivainen, Reina, additional, Rytířová, Gisela, additional, Samsonsen, Christian, additional, Sansa Fayos, Gemma, additional, Saukkonen, Anna Maija, additional, Sikiric, Alma, additional, Sopelana Garay, David, additional, Steinhoff, Bernhard, additional, Strandberg, Maria, additional, Svendsen, Torleiv, additional, Tauboll, Erik, additional, Terada, Kiyohito, additional, Trivisano, Marina, additional, Turner, Katherine, additional, Worm, Mogens, additional, Zakharia, Elias, additional, Zambrelli, Elena, additional, and Zarifi-Oskoie, Morteza, additional

Published
2018
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29. TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk

Author

Lim, Hye Kyung, Pauwels, Elodie, Rönnelid, Ylva, Cai, Xin, Boucherit, Soraya, Jouanguy, Emmanuelle, Paetau, Anders, Lebon, Pierre, Rozenberg, Flore, Tardieu, Marc, Abel, Laurent, Seppänen, Mikko, Yildiran, Alisan, Vergison, Anne, Roivainen, Reina, Etzioni, Amos, Tienari, Pentti P.J., Casanova, Jean-Laurent, Shen, Ying, Hautala, Timo, Ciancanelli, Michael M.J., Itan, Yuval, Lafaille, Fabien F.G., Dell, William, Lorenzo, Lazaro, Byun, Minji, Lim, Hye Kyung, Pauwels, Elodie, Rönnelid, Ylva, Cai, Xin, Boucherit, Soraya, Jouanguy, Emmanuelle, Paetau, Anders, Lebon, Pierre, Rozenberg, Flore, Tardieu, Marc, Abel, Laurent, Seppänen, Mikko, Yildiran, Alisan, Vergison, Anne, Roivainen, Reina, Etzioni, Amos, Tienari, Pentti P.J., Casanova, Jean-Laurent, Shen, Ying, Hautala, Timo, Ciancanelli, Michael M.J., Itan, Yuval, Lafaille, Fabien F.G., Dell, William, Lorenzo, Lazaro, and Byun, Minji

Abstract

Objective: To determine the proportion of children with herpes simplex encephalitis (HSE) displaying TLR3 deficiency, the extent of TLR3 allelic heterogeneity, and the specific clinical features of TLR3 deficiency. Methods: We determined the sequence of all exons of TLR3 in 110 of the 120 patients with HSE enrolled in our study who do not carry any of the previously described HSE-predisposing mutations of TLR3 pathway genes (TLR3, UNC93B1, TRIF, TRAF3, and TBK1). All the new mutant TLR3 alleles detected were characterized experimentally in-depth to establish the causal relationship between the genotype and phenotype. Results: In addition to the 3 previously reported TLR3-deficient patients from the same cohort, 6 other children or young adults with HSE carry 1 of 5 unique or extremely rare (minor allele frequency ,0.001) missense TLR3 alleles. Two alleles (M374T, D592N) heterozygous in 3 patients are not deleterious in vitro. The other 3 are deleterious via different mechanisms: G743D1R811I and L360P heterozygous in 2 patients are loss-of-function due to low levels of expression and lack of cleavage, respectively, and R867Q homozygous in 1 patient is hypomorphic. The 3 patients' fibroblasts display impaired TLR3 responses and enhanced herpes simplex virus 1 susceptibility. Overall, TLR3 deficiency is therefore found in 6 (5%) of the 120 patients studied. There is high allelic heterogeneity, with 3 forms of autosomal dominant partial defect by negative dominance or haploinsufficiency, and 2 forms of autosomal recessive defect with complete or partial deficiency. Finally, 4 (66%) of the 6 TLR3-deficient patients had at least 1 late relapse of HSE, whereas relapse occurred in only 12 (10%) of the total cohort of 120 patients. Conclusions: Childhood-onset HSE is due to TLR3 deficiency in a traceable fraction of patients, in particular the ones with HSE recurrence. Mutations in TLR3 and TLR3 pathway genes should be searched and experimentally studied in children with HSE, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2014

31. Abstract W MP92: The CAVE Score for Predicting Late Seizures after Intracerebral Hemorrhage

Author

Haapaniemi, Elena, primary, Strbian, Daniel, additional, Rossi, Costanza, additional, Putaala, Jukka, additional, Sipi, Tuulia, additional, Mustanoja, Satu, additional, Sairanen, Tiina, additional, Curtze, Sami, additional, Satopää, Jarno, additional, Roivainen, Reina, additional, Kaste, Markku, additional, Cordonnier, Charlotte, additional, Tatlisumak, Turgut, additional, and Meretoja, Atte, additional

Published
2014
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33. Neuropeptidit suoliston taudeissa

Author

ROIVAINEN, REINA, Lääketieteen laitos - Medical School, Lääketieteellinen tiedekunta - Faculty of Medicine, and University of Tampere

Subjects
Lääketiede - Medicine
Abstract

Syventävä työ ei kirjastossa

Published
1991

34. Combined Perfusion- and Diffusion-weighted MR Imaging in Acute Ischemic Stroke during the 1st Week: A Longitudinal Study

Author

Karonen, Jari O., primary, Liu, Yawu, additional, Vanninen, Ritva L., additional, Østergaard, Leif, additional, Kaarina Partanen, P. L., additional, Vainio, Pauli A., additional, Vanninen, Esko J., additional, Nuutinen, Juho, additional, Roivainen, Reina, additional, Soimakallio, Seppo, additional, Kuikka, Jyrki T., additional, and Aronen, Hannu J., additional

Published
2000
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38. TLR3 deficiency in herpes simplex encephalitis

Author

Lim, Hye Kyung, Seppänen, Mikko, Hautala, Timo, Ciancanelli, Michael J., Itan, Yuval, Lafaille, Fabien G., Dell, William, Lorenzo, Lazaro, Byun, Minji, Pauwels, Elodie, Rönnelid, Ylva, Cai, Xin, Boucherit, Soraya, Jouanguy, Emmanuelle, Paetau, Anders, Lebon, Pierre, Rozenberg, Flore, Tardieu, Marc, Abel, Laurent, Yildiran, Alisan, Vergison, Anne, Roivainen, Reina, Etzioni, Amos, Tienari, Pentti J., Casanova, Jean-Laurent, and Zhang, Shen-Ying

Published
2014
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43. Facial paralysis associated with drug reaction with eosinophilia and systemic symptoms (DRESS) with oxcarbazepine and reactivation of human herpesvirus 6 (HHV‐6).

Author

Kluger, Nicolas, Descamps, Vincent, Lappalainen, Katriina, and Roivainen, Reina

Subjects
DRUG side effects, FACIAL paralysis, ENTRAPMENT neuropathies
Abstract

Facial paralysis associated with drug reaction with eosinophilia and systemic symptoms (DRESS) with oxcarbazepine and reactivation of human herpesvirus 6 (HHV-6) Drug reaction with eosinophilia and systemic symptoms (DRESS) is a serious, potentially life-threatening drug-induced reaction.[1] Various and possibly severe organ involvement have been described, such as hepatitis, hemophagocytosis, encephalitis, hypoxemic pneumopathy, or myocarditis. Liver enzyme tests showed acute cytolytic hepatitis (alanine aminotransferase [ALT], 15 times normal range), and lactic dehydrogenase (LDH) was elevated 442 U/l. Hepatitis B, hepatitis C, human immunodeficiency virus (HIV), and cytomegalovirus (CMV) serologies were negative, and Epstein-Barr virus (EBV) and hepatitis A serologies were consistent with old exposure. [Extracted from the article]

Published
2020
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48. Injuryinduced longterm expression of immediate early genes in the rat superior cervical ganglion

Author

Koistinaho, Jari, Pelto-Huikko, Markku, Sagar, Stephen M., Dagerlind, Åke, Roivainen, Reina, and Hökfelt, Tomas

Abstract

USING in situhybridization histochemistry and immunocytochemistry the induction of immediate early genes (IEGs) was studied in the rat superior cervical ganglion (SCG) after deafferentation, axotomy and sialectomy (removal of the submandibular gland). Control SCGs showed very low levels of IEGs, whereby Fos proteins were found in 1 and Jun protein in 6 of neurons, but not in non-neuronal cells. Denervation and axotomy induced C-fos, NGFI-A, c-jun, junB and junD mRNA expression for up to 6 days in non-neuronal cells, whereas in sympathetic neurons the expression of only c-junmRNA was induced after axotomy and sialectomy. The induction of Fos and Jun proteins by neuronal injury was demonstrated by immunocytochemistry. The results indicate that neuronal injury induces IEGs mainly in non-neuronal cells and that in neurons only c-junis induced after axotomy. It is hypothesized that the induction of IEG other than c-junin neurons after brain injury is an indirect event unrelated to the neuronal response to injury.

Published
1993

49. Abstract W MP92.

Author

Haapaniemi, Elena, Strbian, Daniel, Rossi, Costanza, Putaala, Jukka, Sipi, Tuulia, Mustanoja, Satu, Sairanen, Tiina, Curtze, Sami, Satopää, Jarno, Roivainen, Reina, Kaste, Markku, Cordonnier, Charlotte, Tatlisumak, Turgut, and Meretoja, Atte

Published
2014

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