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5. Prognostic models in COVID-19 infection that predict severity: a systematic review

Author

Buttia, Chepkoech, Llanaj, Erand, Raeisi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Taneri, Petek Eylul, Ochoa, Sergio Alejandro Gómez, Raguindin, Peter Francis, Wehrli, Faina, Khatami, Farnaz, Espínola, Octavio Pano, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Ehrhard, Simone, Que, Yok-Ai, Fernandes, Laurenz Kopp, Hautz, Wolf, and Muka, Taulant

Published
2023
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8. Anemia and iron metabolism in COVID-19 : a systematic review and meta-analysis

Author

Taneri, Petek Eylul, Gómez-Ochoa, Sergio Alejandro, Llanaj, Erand, Raguindin, Peter Francis, Rojas, Lyda Z., Roa-Díaz, Zayne Milena, Salvador, Dante, Groothof, Dion, Minder, Beatrice, Kopp-Heim, Doris, Hautz, Wolf E., Eisenga, Michele F., Franco, Oscar H., Glisic, Marija, and Muka, Taulant

Published
2020

9. Myocardial Fibrosis by Magnetic Resonance and Outcomes in Chagas Disease: A Systematic Review and Meta-Analysis

Author

Cardiometabolic Health, Gómez-Ochoa, Sergio A., Rojas, Lyda Z., Hernández-Vargas, Juliana A., Trujillo-Cáceres, Silvia J., Hurtado-Ortiz, Alexandra, Licht-Ardila, Maricel, Guarín-Aragón, Michelle A., Rochitte, Carlos E., Morillo, Carlos A., Echeverría, Luis E., Cardiometabolic Health, Gómez-Ochoa, Sergio A., Rojas, Lyda Z., Hernández-Vargas, Juliana A., Trujillo-Cáceres, Silvia J., Hurtado-Ortiz, Alexandra, Licht-Ardila, Maricel, Guarín-Aragón, Michelle A., Rochitte, Carlos E., Morillo, Carlos A., and Echeverría, Luis E.

Published
2024

11. Myocardial Fibrosis by Magnetic Resonance and Outcomes in Chagas Disease

Author

Gómez-Ochoa, Sergio A., primary, Rojas, Lyda Z., additional, Hernández-Vargas, Juliana A., additional, Trujillo-Cáceres, Silvia J., additional, Hurtado-Ortiz, Alexandra, additional, Licht-Ardila, Maricel, additional, Guarín-Aragón, Michelle A., additional, Rochitte, Carlos E., additional, Morillo, Carlos A., additional, and Echeverría, Luis E., additional

Published
2023
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18. Prognostic models in COVID-19 infection that predict severity: a systematic review

Author

Raguindin, Peter Francis, Buttia, Chepkoech, Llanaj, Erand, Raesi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Eylul Taneri, Petek, Ochoa, Sergio Alejandro, Gómez, Wehrli, Faina, Khatami, Farnaz, Pano Espínola, Octavio, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Erhard, Simone, Que, Yok-Ai, Kopp Fernandes, Laurenz, Hautz, Wolf, Muka, Taulant, Raguindin, Peter Francis, Buttia, Chepkoech, Llanaj, Erand, Raesi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Eylul Taneri, Petek, Ochoa, Sergio Alejandro, Gómez, Wehrli, Faina, Khatami, Farnaz, Pano Espínola, Octavio, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Erhard, Simone, Que, Yok-Ai, Kopp Fernandes, Laurenz, Hautz, Wolf, and Muka, Taulant

Abstract

Current evidence on COVID-19 prognostic models is inconsistent and clinical applicability remains controversial. We performed a systematic review to summarize and critically appraise the available studies that have developed, assessed and/or validated prognostic models of COVID-19 predicting health outcomes. We searched six bibliographic databases to identify published articles that investigated univariable and multivariable prognostic models predicting adverse outcomes in adult COVID-19 patients, including intensive care unit (ICU) admission, intubation, high-flow nasal therapy (HFNT), extracorporeal membrane oxygenation (ECMO) and mortality. We identified and assessed 314 eligible articles from more than 40 countries, with 152 of these studies presenting mortality, 66 progression to severe or critical illness, 35 mortality and ICU admission combined, 17 ICU admission only, while the remaining 44 studies reported prediction models for mechanical ventilation (MV) or a combination of multiple outcomes. The sample size of included studies varied from 11 to 7,704,171 participants, with a mean age ranging from 18 to 93 years. There were 353 prognostic models investigated, with area under the curve (AUC) ranging from 0.44 to 0.99. A great proportion of studies (61.5%, 193 out of 314) performed internal or external validation or replication. In 312 (99.4%) studies, prognostic models were reported to be at high risk of bias due to uncertainties and challenges surrounding methodological rigor, sampling, handling of missing data, failure to deal with overfitting and heterogeneous definitions of COVID-19 and severity outcomes. While several clinical prognostic models for COVID-19 have been described in the literature, they are limited in generalizability and/or applicability due to deficiencies in addressing fundamental statistical and methodological concerns. Future large, multi-centric and well-designed prognostic prospective studies are needed to clarify remaining, + ID der Publikation: unilu_64313 + Sprache: Englisch + Letzte Aktualisierung: 2023-03-24 10:52:13

Published
2023

19. Prognostic models in COVID-19 infection that predict severity:a systematic review

Author

Buttia, Chepkoech, Llanaj, Erand, Raeisi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Taneri, Petek Eylul, Ochoa, Sergio Alejandro Gómez, Raguindin, Peter Francis, Wehrli, Faina, Khatami, Farnaz, Espínola, Octavio Pano, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Ehrhard, Simone, Que, Yok Ai, Fernandes, Laurenz Kopp, Hautz, Wolf, Muka, Taulant, Buttia, Chepkoech, Llanaj, Erand, Raeisi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Taneri, Petek Eylul, Ochoa, Sergio Alejandro Gómez, Raguindin, Peter Francis, Wehrli, Faina, Khatami, Farnaz, Espínola, Octavio Pano, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Ehrhard, Simone, Que, Yok Ai, Fernandes, Laurenz Kopp, Hautz, Wolf, and Muka, Taulant

Abstract

Current evidence on COVID-19 prognostic models is inconsistent and clinical applicability remains controversial. We performed a systematic review to summarize and critically appraise the available studies that have developed, assessed and/or validated prognostic models of COVID-19 predicting health outcomes. We searched six bibliographic databases to identify published articles that investigated univariable and multivariable prognostic models predicting adverse outcomes in adult COVID-19 patients, including intensive care unit (ICU) admission, intubation, high-flow nasal therapy (HFNT), extracorporeal membrane oxygenation (ECMO) and mortality. We identified and assessed 314 eligible articles from more than 40 countries, with 152 of these studies presenting mortality, 66 progression to severe or critical illness, 35 mortality and ICU admission combined, 17 ICU admission only, while the remaining 44 studies reported prediction models for mechanical ventilation (MV) or a combination of multiple outcomes. The sample size of included studies varied from 11 to 7,704,171 participants, with a mean age ranging from 18 to 93 years. There were 353 prognostic models investigated, with area under the curve (AUC) ranging from 0.44 to 0.99. A great proportion of studies (61.5%, 193 out of 314) performed internal or external validation or replication. In 312 (99.4%) studies, prognostic models were reported to be at high risk of bias due to uncertainties and challenges surrounding methodological rigor, sampling, handling of missing data, failure to deal with overfitting and heterogeneous definitions of COVID-19 and severity outcomes. While several clinical prognostic models for COVID-19 have been described in the literature, they are limited in generalizability and/or applicability due to deficiencies in addressing fundamental statistical and methodological concerns. Future large, multi-centric and well-designed prognostic prospective studies are needed to clarify remaining uncer

Published
2023

20. Prognostic models in COVID-19 infection that predict severity: a systematic review

Author

Cardiometabolic Health, Buttia, Chepkoech, Llanaj, Erand, Raeisi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Taneri, Petek Eylul, Ochoa, Sergio Alejandro Gómez, Raguindin, Peter Francis, Wehrli, Faina, Khatami, Farnaz, Espínola, Octavio Pano, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Ehrhard, Simone, Que, Yok Ai, Fernandes, Laurenz Kopp, Hautz, Wolf, Muka, Taulant, Cardiometabolic Health, Buttia, Chepkoech, Llanaj, Erand, Raeisi-Dehkordi, Hamidreza, Kastrati, Lum, Amiri, Mojgan, Meçani, Renald, Taneri, Petek Eylul, Ochoa, Sergio Alejandro Gómez, Raguindin, Peter Francis, Wehrli, Faina, Khatami, Farnaz, Espínola, Octavio Pano, Rojas, Lyda Z., de Mortanges, Aurélie Pahud, Macharia-Nimietz, Eric Francis, Alijla, Fadi, Minder, Beatrice, Leichtle, Alexander B., Lüthi, Nora, Ehrhard, Simone, Que, Yok Ai, Fernandes, Laurenz Kopp, Hautz, Wolf, and Muka, Taulant

Published
2023

24. Contribution of nursing research to fighting against COVID-19 pandemic. A systematic review

Author

Rojas, Lyda Z., Hernández Vargas, Juliana Alexandra, Trujillo-Cáceres, Silvia Juliana, and Romero Guevara, Sandra Lucrecia

Subjects
Atención de Enfermería, Betacoronavirus, Infectes por Coronavirus, Cuidados de Enfermagem, Revisão sistemática, Nursing Care, Revisión Sistemática, Systematic Review, Coronavirus Infections, Infecciones por Coronavirus, Pandemics, Pandemias
Abstract

Introduction: The 2019 coronavirus disease (COVID-19) pandemic, should be an opportunity to ensure greater visibility of nursing in health systems and society worldwide. Objective: Review and synthesize the patterns on COVID-19 and nursing research, identifying the main journals, country of origin, language, topics, designs, and area of applicability of the results. Materials and Methods: Systematic review. Searches in PubMed, CINAHL, LILACS, and EMBASE databases (from the inception of the pandemic to May 15, 2020) were performed. Articles of any language related were related to SARS-CoV-2 infection or COVID-19 disease and nursing in any of its roles (care, management, education, among others) and using any epidemiological design or a scientific report were included. Two reviewers independently selected the studies and extracted the data. The main findings from the included studies were summarized through narrative synthesis and descriptive tables. The characteristics of the studies were presented as absolute values and proportions. Results: Three hundred and sixty-five articles were assessed for eligibility. Thirty-eight were included, published in 28 journals. Of those, 53.57% (n=15) were nursing specific. Most articles were “narrative reviews”, accounting for 23.68% (n=9). Most studies were conducted in China (n=18, 47.37%), followed by the United Kingdom and the United States. Thirty-four (89.47%) articles were published in English, followed by Portuguese and Chinese. We identified five areas of application of the results, and the most frequent was the “clinical” setting with 47.00% (n=18). Discussion: These findings are crucial to give visibility to nursing work during the emergency of the COVID-19 pandemic. Mental health was the main research topic, while the clinical setting concentrates the major number of articles. This pattern was aligned with the challenges of the initial phase of the pandemic. Conclusion: Future research should explore the current state of evidence in the main topics identified in this review and continue to give visibility to work carried out by nursing in the emergency of the COVID-19 pandemic. Resumen Introducción: La pandemia de la enfermedad de coronavirus 2019 (COVID-19), debería ser una oportunidad para asegurar una mayor visibilidad de la enfermería en los sistemas de salud y la sociedad en todo el mundo. Objetivo: revisar y sintetizar los patrones de investigación en enfermería y COVID-19, identificando las principales revistas, país de origen, idioma, temas, diseños y área de aplicabilidad de los resultados. Materiales y Métodos: Una revisión sistemática. Se realizaron búsquedas en las bases de datos PubMed, CINAHL, LILACS y EMBASE (desde el inicio de la pandemia hasta el 15 de mayo de 2020). Se incluyeron artículos de cualquier idioma relacionados con la infección por SARS-CoV-2 o COVID-19 y enfermería en cualquiera de sus roles (cuidado, administración, educación, entre otros) que utilizaron cualquier diseño epidemiológico o informe científico. Dos revisores seleccionaron de forma independiente los estudios y extrajeron los datos. Los principales hallazgos de los estudios incluidos se resumieron mediante una síntesis narrativa y tablas descriptivas. Las características de los estudios se presentaron como valores absolutos y proporciones. Resultados: En 325 artículos se evaluaron los criterios de elegibilidad y se incluyeron 38 publicados en 28 revistas. De ellos, el 53,57% (n=15) eran específicos de enfermería. La mayoría de los artículos fueron “revisiones narrativas”, que representan el 23,68% (n=9). La mayoría de los estudios se realizaron en China (n=18, 47,37%), seguido de Reino Unido y Estados Unidos. Treinta y cuatro (89,47%) artículos se publicaron en inglés, seguidos de portugués y chino. Identificamos cinco áreas de aplicación de los resultados y la más frecuente fue el ámbito “clínico” con un 47,00% (n=18). Discusión: Estos hallazgos son cruciales para dar visibilidad al trabajo de enfermería en la emergencia de la pandemia COVID-19. Se destaca que la salud mental fue el principal tópico de investigación mientras que el escenario clínico concentró el mayor número de artículo. Este patrón estuvo alineado con los desafíos impuestos por la fase inicial de la pandemia. Conclusión: Las investigaciones futuras deberán explorar el estado actual de la evidencia en los principales temas identificados en esta revisión y continuar dando visibilidad al trabajo realizado por enfermería en la emergencia de la pandemia por COVID-19. Resumo Introdujo: A pandemia da doença coronavirus (COVID-19) de 2019 deve ser uma oportunidade para garantir maior visibilidade da enfermagem nos sistemas de saúde e na sociedade em todo o mundo. Objetivo: revisar e sintetizar os padrões de pesquisa em enfermagem e COVID-19, identificando as principais revistas, país de origem, língua, tópicos, desenhos e área de aplicabilidade dos resultados. Materiais e Métodos: Uma revisão sistemática. As bases de dados PubMed, CINAHL, LILACS e EMBASE foram pesquisadas (Do inicio da pandemia até 15 de maio de 2020). Artigos de qualquer língua relacionados a infecto por SARS-CoV-2 ou COVID-19 e enfermagem foram incluídos em qualquer das suas funções (assistência, administrado, educado, entre outras) que utilizassem qualquer desenho epidemiológico ou relatório científico. Dois revisores selecionaram independentemente estudos e extraíram os dados. As principais conclusões dos estudos incluídos foram resumidas através de uma síntese narrativa e tabelas descritivas. As características dos estudos foram apresentadas em valores absolutos e proposes. Resultados: Em 325 artigos foram avaliados os critérios de elegibilidade e incluídos 38 publicados em 28 revistas. Destes, 53,57% (n=15) eram específicos da enfermagem. A maioria dos artigos eram "revisões narrativas", representando 23,68% (n=9). A maioria dos estudos foi realizada na China (n=18, 47,37%), seguida do Reino Unido e dos Estados Unidos. Trinta e quatro (89,47%) artigos foram publicados em inglês, seguidos de português e chinês. Identificamos cinco áreas de aplicado dos resultados e a mais frequente foi a área "clinica" com 47,00% (n=l8). Discussao: Estas conclusões são cruciais para dar visibilidade ao trabalho de enfermagem durante a emergência da pandemia da COVID-19. A saúde mental foi o principal tema de investigado, enquanto que o cenário clinico concentra o maior número de artigos. Este padrão foi alinhado com os desafios da fase inicial da pandemia. Conclusao: A investigado futura deve explorar o estado atual das provas nos principais tópicos identificados nesta revisão e continuar a dar visibilidade ao trabalho realizado pela enfermagem na emergência da pandemia da COVID-19.

Published
2022

25. Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study

Author

Gómez-Ochoa, Sergio Alejandro, Rojas, Lyda Z, Echeverría, Luis E, Muka, Taulant, and Franco, Oscar H

Subjects
Community and Home Care, Male, Epidemiology, Incidence, 360 Soziale Probleme, Sozialdienste, Neglected Diseases, 610 Medicine & health, Global Health, Global Burden of Disease, 360 Social problems & social services, Prevalence, Humans, Chagas Disease, Female, Quality-Adjusted Life Years, 610 Medizin und Gesundheit, Cardiology and Cardiovascular Medicine, Public Health, Aged
Abstract

Background Chagas disease (CD) is a neglected tropical disease, endemic in Latin America, but due to migration and environmental changes it has become a global public health issue. Objectives To assess the global prevalence and disability-adjusted life years due to CD using findings from the Global Burden of Disease Study 2019. Methods The Global Burden of Disease data was obtained from the Global Burden of Disease Collaborative Network; results were provided by the Institute for Health Metrics and Evaluation. The prevalence and disability-adjusted life-years (DALYs) were described at a global, regional, and national level, including data from 1990 to 2019. Results Globally, CD prevalence decreased by 11.3% during the study period, from 7,292,889 cases estimated in 1990 to 6,469,283 in 2019. Moreover, the global DALY rate of CD decreased by 23.7% during the evaluated period, from 360,872 in 1990 to 275,377 in 2019. In addition, significant differences in the burden by sex, being men the most affected, age, with the elderly having the highest burden of the disease, and sociodemographic index (SDI), with countries with the lowest SDI values having the highest prevalence of the disease, were observed. Finally, the prevalence trends have followed different patterns according to the region, with a sustained decrease in Latin America, compared to an increasing trend in North America and Europe until 2010. Conclusion The global burden of CD has changed in recent decades, with a sustained decline in the number of cases. Although the majority of cases remain concentrated in Latin America, the increase observed in countries in North America and Europe highlights the importance of screening at-risk populations and raising awareness of this neglected tropical disease.

Published
2022

28. Gene-diet interactions and cardiovascular diseases:a systematic review of observational and clinical trials

Author

Roa-Díaz, Zayne M., Teuscher, Julian, Gamba, Magda, Bundo, Marvin, Grisotto, Giorgia, Wehrli, Faina, Gamboa, Edna, Rojas, Lyda Z., Gómez-Ochoa, Sergio A., Verhoog, Sanne, Vargas, Manuel Frias, Minder, Beatrice, Franco, Oscar H., Dehghan, Abbas, Pazoki, Raha, Marques-Vidal, Pedro, Muka, Taulant, Roa-Díaz, Zayne M., Teuscher, Julian, Gamba, Magda, Bundo, Marvin, Grisotto, Giorgia, Wehrli, Faina, Gamboa, Edna, Rojas, Lyda Z., Gómez-Ochoa, Sergio A., Verhoog, Sanne, Vargas, Manuel Frias, Minder, Beatrice, Franco, Oscar H., Dehghan, Abbas, Pazoki, Raha, Marques-Vidal, Pedro, and Muka, Taulant

Abstract

Background: Both genetic background and diet are important determinants of cardiovascular diseases (CVD). Understanding gene-diet interactions could help improve CVD prevention and prognosis. We aimed to summarise the evidence on gene-diet interactions and CVD outcomes systematically. Methods: We searched MEDLINE® via Ovid, Embase, PubMed®, and The Cochrane Library for relevant studies published until June 6th 2022. We considered for inclusion cross-sectional, case–control, prospective cohort, nested case–control, and case-cohort studies as well as randomised controlled trials that evaluated the interaction between genetic variants and/or genetic risk scores and food or diet intake on the risk of related outcomes, including myocardial infarction, coronary heart disease (CHD), stroke and CVD as a composite outcome. The PROSPERO protocol registration code is CRD42019147031. Results and discussion: We included 59 articles based on data from 29 studies; six articles involved multiple studies, and seven did not report details of their source population. The median sample size of the articles was 2562 participants. Of the 59 articles, 21 (35.6%) were qualified as high quality, while the rest were intermediate or poor. Eleven (18.6%) articles adjusted for multiple comparisons, four (7.0%) attempted to replicate the findings, 18 (30.5%) were based on Han-Chinese ethnicity, and 29 (49.2%) did not present Minor Allele Frequency. Fifty different dietary exposures and 52 different genetic factors were investigated, with alcohol intake and ADH1C variants being the most examined. Of 266 investigated diet-gene interaction tests, 50 (18.8%) were statistically significant, including CETP-TaqIB and ADH1C variants, which interacted with alcohol intake on CHD risk. However, interactions effects were significant only in some articles and did not agree on the direction of effects. Moreover, most of the studies that reported significant interactions lacked replica

Published
2022

29. Gene-diet interactions and cardiovascular diseases: A systematic review of observational and clinical trials

Author

Roa-Díaz, Zayne M., primary, Teuscher, Julian, additional, Gamba, Magda, additional, Bundo, Marvin, additional, Grisotto, Giorgia, additional, Wehrli, Faina, additional, Gamboa, Edna, additional, Rojas, Lyda Z., additional, Gómez-Ochoa, Sergio, additional, Verhoog, Sanne, additional, Vargas, Manuel Frias, additional, Minder, Beatrice, additional, Franco, Oscar H., additional, Dehghan, Abbas, additional, Pazoki, Raha, additional, Marques-Vidal, Pedro, additional, and Muka, Taulant, additional

Published
2022
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30. Additional file 1 of Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials

Author

Roa-Díaz, Zayne M., Teuscher, Julian, Gamba, Magda, Bundo, Marvin, Grisotto, Giorgia, Wehrli, Faina, Gamboa, Edna, Rojas, Lyda Z., Gómez-Ochoa, Sergio A., Verhoog, Sanne, Vargas, Manuel Frias, Minder, Beatrice, Franco, Oscar H., Dehghan, Abbas, Pazoki, Raha, Marques-Vidal, Pedro, and Muka, Taulant

Abstract

Additional file 1. Search strategy.

Published
2022
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31. Additional file 2 of Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials

Author

Roa-Díaz, Zayne M., Teuscher, Julian, Gamba, Magda, Bundo, Marvin, Grisotto, Giorgia, Wehrli, Faina, Gamboa, Edna, Rojas, Lyda Z., Gómez-Ochoa, Sergio A., Verhoog, Sanne, Vargas, Manuel Frias, Minder, Beatrice, Franco, Oscar H., Dehghan, Abbas, Pazoki, Raha, Marques-Vidal, Pedro, and Muka, Taulant

Abstract

Additional file 2. Supplemental material.

Published
2022
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37. Age at Natural Menopause and Blood Pressure Traits: Mendelian Randomization Study

Author

Roa-Díaz, Zayne M., primary, Asllanaj, Eralda, additional, Amin, Hasnat A., additional, Rojas, Lyda Z., additional, Nano, Jana, additional, Ikram, Mohammad Arfan, additional, Drenos, Fotios, additional, Franco, Oscar H., additional, Pazoki, Raha, additional, Marques-Vidal, Pedro, additional, Voortman, Trudy, additional, and Muka, Taulant, additional

Published
2021
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42. COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes

Author

Gómez-Ochoa, Sergio Alejandro, Franco, Oscar H, Rojas, Lyda Z, Raguindin, Peter Francis, Roa-Díaz, Zayne Milena, Wyssmann Minder, Beatrice, Romero Guevara, Sandra Lucrecia, Echeverría, Luis Eduardo, Glisic, Marija, Muka, Taulant, Gómez-Ochoa, Sergio Alejandro, Franco, Oscar H, Rojas, Lyda Z, Raguindin, Peter Francis, Roa-Díaz, Zayne Milena, Wyssmann Minder, Beatrice, Romero Guevara, Sandra Lucrecia, Echeverría, Luis Eduardo, Glisic, Marija, and Muka, Taulant

Abstract

no abstract available, + "This is a pre-copyedited, author-produced version of an article accepted for publication in American Journal of Epidemiology following peer review. The version of record "American Journal of Epidemiology, Volume 190, Issue 1, January 2021, Pages 161–175" is available online at: https://academic.oup.com and https://doi.org/10.1093/aje/kwaa191."+ ID der Publikation: unilu_68006 + Sprache: Englisch + Letzte Aktualisierung: 2023-04-24 12:48:07

Published
2021

43. Circulating MicroRNAs and myocardial involvement severity in chronic Chagas cardiomyopathy.

Author

Alejandro Gómez-Ochoa, Sergio, Katherine Bautista-Niño, Paula, Rojas, Lyda Z., Hunziker, Lukas, Muka, Taulant, and Echeverría, Luis E.

Subjects
MYOCARDIAL reperfusion, MICRORNA, DIASTOLE (Cardiac cycle), PROPORTIONAL hazards models, HEART assist devices, CARDIOMYOPATHIES, LEFT heart atrium, PROTEIN-tyrosine kinases
Abstract

Background: Chronic Chagas Cardiomyopathy (CCM) is characterized by a unique pathophysiology in which inflammatory, microvascular and neuroendocrine processes coalesce in the development of one of the most severe cardiomyopathies affecting humans. Despite significant advances in understanding the molecular mechanisms involved in this disease, scarce information is available regarding microRNAs and clinical parameters of disease severity. We aimed to evaluate the association between circulating levels of six microRNAs with markers of myocardial injury and prognosis in this population. Methods: Patients with CCM and reduced ejection fraction were included in a prospective exploratory cohort study. We assessed the association of natural log-transformed values of six circulating microRNAs (miR-34a-5p, miR-208a-5p, miR-185-5p, miR-223-5p, let-7d-5p, and miR-454-5p) with NT-proBNP levels and echocardiographic variables using linear regression models adjusted for potential confounders. By using Cox Proportional Hazard models, we examined whether levels of microRNAs could predict a composite outcome (CO), including all-cause mortality, cardiac transplantation, and implantation of a left ventricular assist device (LVAD). Finally, for mRNAs showing significant associations, we predicted the target genes and performed pathway analyses using Targetscan and Reactome Pathway Browser. Results: Seventy-four patients were included (59% males, median age: 64 years). After adjustment for age, sex, body mass index, and heart failure medications, only increasing miR-223-5p relative expression levels were significantly associated with better myocardial function markers, including left atrium area (Coef. -10.2; 95% CI -16.35; -4.09), end-systolic (Coef. -45.3; 95% CI -74.06; -16.61) and end-diastolic volumes (Coef. -46.1; 95% CI -81.99; -10.26) of the left ventricle. Moreover, we observed that higher miR-223-5p levels were associated with better left-ventricle ejection fraction and lower NTproBNP levels. No associations were observed between the six microRNAs and the composite outcome. A total of 123 target genes for miR-223-5p were obtained. From these, several target pathways mainly related to signaling by receptor tyrosine kinases were identified. Conclusions: The present study found an association between miR-223-5p and clinical parameters of CCM, with signaling pathways related to receptor tyrosine kinases as a potential mechanism linking low levels of miR-223-5p with CCM worsening. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Cardiotoxicidad por antraciclinas en supervivientes de cáncer durante la infancia.

Author

Ramos Garzón, Judy Ximena, Achury Beltrán, Luisa Fernanda, and Rojas, Lyda Z.

Subjects
CARDIOTOXICITY, PATIENT aftercare, ANTHRACYCLINES, VENTRICULAR remodeling, MEDICAL care, TUMORS in children, CANCER patients, CARDIOVASCULAR system, CARDIOTONIC agents, CHILDREN
Abstract

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Published
2022
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47. Circulating DHEA-S levels and major cardiovascular outcomes in chronic Chagas cardiomyopathy: A prospective cohort study.

Author

Rojas, Lyda Z., Gómez-Ochoa, Sergio Alejandro, Echeverría, Luis E., Bautista-Niño, Paula Katherine, Hunziker, Lukas, Eisenga, Michele F., and Muka, Taulant

Subjects
*HEART assist devices, *COHORT analysis, *PROPORTIONAL hazards models, *LONGITUDINAL method, *CARDIOMYOPATHIES
Abstract

To analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM) diagnosis. DHEA-S is among the main endogenous steroid hormones. Some studies have suggested a relevant role of this hormone in infections and the setting of CCM. Nevertheless, no study has evaluated the prognostic role of DHEA-S in CCM patients. Prospective cohort study. Patients with CCM and reduced ejection fraction were included. We explored the association of DHEA-S levels with NT-proBNP levels and echocardiographic variables using linear regression models. Next, by using Cox Proportional Hazard models, we examined whether levels of DHEA-S could predict a composite outcome (CO) including all-cause mortality, cardiac transplantation, and implantation of a left ventricular assist device (LVAD). Seventy-four patients were included (59% males, median age: 64 years). After adjustment for confounding factors, high DHEA-S levels were associated with better LVEF, lower left atrium volume, end-systolic volume of the left ventricle and lower NT-proBNP levels. 43% of patients experienced the CO during a median follow-up of 40 months. Increased levels of DHEA-S were associated with a lower risk of developing the CO (HR 0.43; 95%CI 0.21-0.86). Finally, adding DHEA-S to the multivariate model did not improve the prediction of the CO, but substituting NT-proBNP in the model with DHEA-S showed similar performance. In patients with CCM, higher DHEA-S levels were associated with lower mortality, heart transplantation, and LVAD implantation. Further larger studies are required to confirm our results and assess causality. Central illustration. In the present study, lower circulating dehydroepiandrosterone sulfate (DHEA-S) levels were associated with a higher risk of adverse major cardiovascular outcomes (cardiovascular mortality, LVAD implantation, and heart transplantation) in patients with Chronic Chagas Cardiomyopathy (CCM). Several mechanisms may explain the potential protective role of DHEA-S in CCM, either by direct or indirect processes. T. cruzi can impair dehydroepiandrosterone and DHEA-S synthesis in the adrenal glands by direct invasion of the adrenal tissue and/or by promoting the release of proinflammatory cytokines such as TGF-β. [Display omitted] • Chronic Chagas Cardiomyopathy (CCM) is characterized by a high morbimortality. • In CCM patients, DHEA-S levels were associated with better LVEF and lower NT-proBNP. • Increased DHEA-S levels were associated with a lower risk of mortality. • DHEA-S predictive value was independent of LVEF and NT-proBNP. • DHEA-S may be useful as a biomarker for mortality prediction in CCM patients. [ABSTRACT FROM AUTHOR]

Published
2022
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49. COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes

Author

Gómez-Ochoa, Sergio Alejandro, primary, Franco, Oscar H, additional, Rojas, Lyda Z, additional, Raguindin, Peter Francis, additional, Roa-Díaz, Zayne Milena, additional, Wyssmann, Beatrice Minder, additional, Guevara, Sandra Lucrecia Romero, additional, Echeverría, Luis Eduardo, additional, Glisic, Marija, additional, and Muka, Taulant, additional

Published
2020
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50. Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis

Author

Taneri, Petek Eylul, primary, Alejandro Gómez-Ochoa, Sergio, additional, Llanaj, Erand, additional, Francis Raguindin, Peter, additional, Rojas, Lyda Z., additional, Wyssmann, Beatrice Minder, additional, Kopp-Heim, Doris, additional, Hautz, Wolf E., additional, Eisenga, Michele F., additional, Franco, Oscar H., additional, Glisic, Marija, additional, and Muka, Taulant, additional

Published
2020
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