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1. Association between anti-PL7 antibodies and increased fibrotic component in patients with antisynthetase syndrome and interstitial lung disease: a cross-sectional study

Author

Rivero-Gallegos, Daphne, Mejía, Mayra, Rocha-González, Héctor I., Huerta-Cruz, Juan C., Falfán-Valencia, Ramcés, Ramos-Martínez, Espiridion, Mateos-Toledo, Heidegger N., Castillo-López, María F., Rodríguez-Torres, Yeimi K., Lira-Boussart, Valeria, and Rojas-Serrano, Jorge

Published
2024
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2. Update of the guidelines for the pharmacological treatment of rheumatoid arthritis by the Mexican College of Rheumatology 2023

Author

Abud-Mendoza, Carlos, Aceves-Ávila, Francisco Javier, Arce-Salinas, César Alejandro, Álvarez Nemegyei, José, Barile-Fabris, Leonor, Durán-Barragán, Sergio, Flores-Alvarado, Diana Elsa, Hernández-Núñez, Eufrates, Irazoque-Palazuelos, Fedra, Moctezuma-Ríos, José Francisco, Pascual-Ramos, Virginia, Portela-Hernández, Margarita, Silveira, Luis Humberto, Andrade-Ortega, Lilia, Barrera-Vargas, Ana, Carrillo-Vázquez, Sandra, Castro-Colin, Zully, Cuevas-Orta, Enrique, Flores-Suárez, Luis Felipe, Guaracha-Basáñez, Guillermo Arturo, Hernández-Cabrera, María Fernanda, de Jesús Hernández-Galarza, Iván, Herrera-vanOostdam, David Alejandro, Lobato-Belmonte, Adriana Concepción, Martínez-Martínez, Laura Aline, Martínez-Martínez, Marco Ulises, Medrano-Ramírez, Gabriel, Merayo-Chalico, Francisco Javier, Meza-López y Olguín, Graciela, Olan, Francisco, Peña-Santos, Genaro, Ramos-Remus, César, Reyes-Cordero, Greta, Rivera-Terán, Vijaya, Rojas-Serrano, Jorge, Serna-Peña, Griselda, Sicsik-Ayala, Sandra, Sifuentes-Cantú, César Armando, Vega-Morales, David, Villaseñor-Ovies, Pablo, Xibillé-Friedmann, Daniel, and Pacheco-Tena, César

Published
2024
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3. Actualización de las Guías para el Tratamiento Farmacológico de la Artritis Reumatoide del Colegio Mexicano de Reumatología 2023

Author

Abud-Mendoza, Carlos, Aceves-Ávila, Francisco Javier, Arce-Salinas, César Alejandro, Álvarez Nemegyei, José, Barile-Fabris, Leonor, Durán-Barragán, Sergio, Flores-Alvarado, Diana Elsa, Hernández-Núñez, Eufrates, Irazoque-Palazuelos, Fedra, Moctezuma-Ríos, José Francisco, Pascual-Ramos, Virginia, Portela-Hernández, Margarita, Silveira, Luis Humberto, Andrade-Ortega, Lilia, Barrera-Vargas, Ana, Carrillo-Vázquez, Sandra, Castro-Colin, Zully, Cuevas-Orta, Enrique, Flores-Suárez, Luis Felipe, Guaracha-Basáñez, Guillermo Arturo, Hernández-Cabrera, María Fernanda, Hernández-Galarza, Iván de Jesús, Herrera-vanOostdam, David Alejandro, Lobato-Belmonte, Adriana Concepción, Martínez-Martínez, Laura Aline, Martínez-Martínez, Marco Ulises, Medrano-Ramírez, Gabriel, Merayo-Chalico, Francisco Javier, Meza-López y Olguín, Graciela, Olan, Francisco, Peña-Santos, Genaro, Ramos-Remus, César, Reyes-Cordero, Greta, Rivera-Terán, Vijaya, Rojas-Serrano, Jorge, Serna-Peña, Griselda, Sicsik-Ayala, Sandra, Sifuentes-Cantú, César Armando, Vega-Morales, David, Villaseñor-Ovies, Pablo, Xibillé-Friedmann, Daniel, and Pacheco-Tena, César

Published
2024
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6. MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression

Author

Juge, Pierre-Antoine, Solomon, Joshua J, van Moorsel, Coline HM, Garofoli, Romain, Lee, Joyce S, Louis-Sydney, Fabienne, Rojas-Serrano, Jorge, González-Pérez, Montserrat I, Mejia, Mayra, Buendia-Roldán, Ivette, Falfán-Valencia, Ramcés, Ambrocio-Ortiz, Enrique, Manali, Effrosyni, Papiris, Spyros A, Karageorgas, Theofanis, Boumpas, Dimitrios, Antoniou, Katarina M, Sidiropoulos, Prodromos, Trachalaki, Athina, van der Vis, Joanne J, Jamnitski, Anna, Grutters, Jan C, Kannengiesser, Caroline, Borie, Raphaël, Kawano-Dourado, Leticia, Wemeau-Stervinou, Lidwine, Flipo, René-Marc, Nunes, Hilario, Uzunhan, Yurdagul, Valeyre, Dominique, Saidenberg-Kermanac'h, Nathalie, Boissier, Marie-Christophe, Richez, Christophe, Schaeverbeke, Thierry, Doyle, Tracy, Wolters, Paul J, Debray, Marie-Pierre, Boileau, Catherine, Porcher, Raphaël, Schwartz, David A, Crestani, Bruno, and Dieudé, Philippe

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Genetics, Lung, Autoimmune Disease, Rare Diseases, Arthritis, Inflammatory and immune system, Respiratory, Aged, Arthritis, Rheumatoid, Female, Humans, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Mucin-5B, Promoter Regions, Genetic, Rheumatoid Arthritis, Interstitial Lung Disease, MUC5B, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

BackgroundThe major risk factor for idiopathic pulmonary fibrosis (IPF), MUC5B rs35705950, was found to be associated with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Whilst the MUC5B rs35705950 T risk allele has been associated with better survival in IPF, its impact on RA-ILD prognosis remains to be determined. Our objective was to explore the influence of MUC5B rs35705950 on survival and progression in RA-ILD.MethodsThrough an international retrospective observational study, patients with RA-ILD were genotyped for the MUC5B rs35705950 variant and consecutive pulmonary function tests (PFTs) findings were collected. Longitudinal data up to a 10-year follow-up were considered and analyzed using mixed regression models. Proportional hazards and joint proportional hazards models were used to analyze the association of baseline and longitudinal variables with lung transplant-free survival. Significant progression of RA-ILD was defined as at least an absolute or relative 10% decline of forced vital capacity at 2 years from baseline.ResultsOut of 321 registered patients, 261 were included in the study: 139 women (53.3%), median age at RA-ILD diagnosis 65 years (interquartile range [IQR] 57 to 71), 151 ever smokers (59.2%). Median follow-up was 3.5 years (IQR 1.3 to 6.6). Mortality rate was 32% (95%CI 19 to 42) at 10 years. The MUC5B rs35705950 variant did not impact lung transplant-free survival (HR for the T risk allele carriers=1.26; 95%CI 0.61 to 2.62; P=0.53). Decline in pulmonary function at 2 years was not influenced by MUC5B rs35705950 (OR=0.95; 95%CI 0.44 to 2.05; P=0.89), irrespective of the HRCT pattern.ConclusionIn this study, the MUC5B rs35705950 promoter variant did not influence transplant- free survival or decline in pulmonary function in patients with RA-ILD.

Published
2021

8. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Author

Juge, Pierre-Antoine, Lee, Joyce S, Ebstein, Esther, Furukawa, Hiroshi, Dobrinskikh, Evgenia, Gazal, Steven, Kannengiesser, Caroline, Ottaviani, Sébastien, Oka, Shomi, Tohma, Shigeto, Tsuchiya, Naoyuki, Rojas-Serrano, Jorge, González-Pérez, Montserrat I, Mejía, Mayra, Buendía-Roldán, Ivette, Falfán-Valencia, Ramcés, Ambrocio-Ortiz, Enrique, Manali, Effrosyni, Papiris, Spyros A, Karageorgas, Theofanis, Boumpas, Dimitrios, Antoniou, Katarina, van Moorsel, Coline HM, van der Vis, Joanne, de Man, Yaël A, Grutters, Jan C, Wang, Yaping, Borie, Raphaël, Wemeau-Stervinou, Lidwine, Wallaert, Benoît, Flipo, René-Marc, Nunes, Hilario, Valeyre, Dominique, Saidenberg-Kermanac’h, Nathalie, Boissier, Marie-Christophe, Marchand-Adam, Sylvain, Frazier, Aline, Richette, Pascal, Allanore, Yannick, Sibilia, Jean, Dromer, Claire, Richez, Christophe, Schaeverbeke, Thierry, Lioté, Huguette, Thabut, Gabriel, Nathan, Nadia, Amselem, Serge, Soubrier, Martin, Cottin, Vincent, Clément, Annick, Deane, Kevin, Walts, Avram D, Fingerlin, Tasha, Fischer, Aryeh, Ryu, Jay H, Matteson, Eric L, Niewold, Timothy B, Assayag, Deborah, Gross, Andrew, Wolters, Paul, Schwarz, Marvin I, Holers, Michael, Solomon, Joshua J, Doyle, Tracy, Rosas, Ivan O, Blauwendraat, Cornelis, Nalls, Mike A, Debray, Marie-Pierre, Boileau, Catherine, Crestani, Bruno, Schwartz, David A, and Dieudé, Philippe

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Lung, Rare Diseases, Autoimmune Disease, Genetics, Clinical Research, Arthritis, Rheumatoid Arthritis, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Respiratory, Aged, Arthritis, Rheumatoid, Female, Gain of Function Mutation, Genetic Predisposition to Disease, Genotype, Humans, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Male, Middle Aged, Mucin-5B, Odds Ratio, Promoter Regions, Genetic, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundGiven the phenotypic similarities between rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that the strongest risk factor for the development of idiopathic pulmonary fibrosis, the gain-of-function MUC5B promoter variant rs35705950, would also contribute to the risk of ILD among patients with RA.MethodsUsing a discovery population and multiple validation populations, we tested the association of the MUC5B promoter variant rs35705950 in 620 patients with RA-ILD, 614 patients with RA without ILD, and 5448 unaffected controls.ResultsAnalysis of the discovery population revealed an association of the minor allele of the MUC5B promoter variant with RA-ILD when patients with RA-ILD were compared with unaffected controls (adjusted odds ratio, 3.8; 95% confidence interval [CI], 2.8 to 5.2; P=9.7×10-17). The MUC5B promoter variant was also significantly overrepresented among patients with RA-ILD, as compared with unaffected controls, in an analysis of the multiethnic case series (adjusted odds ratio, 5.5; 95% CI, 4.2 to 7.3; P=4.7×10-35) and in a combined analysis of the discovery population and the multiethnic case series (adjusted odds ratio, 4.7; 95% CI, 3.9 to 5.8; P=1.3×10-49). In addition, the MUC5B promoter variant was associated with an increased risk of ILD among patients with RA (adjusted odds ratio in combined analysis, 3.1; 95% CI, 1.8 to 5.4; P=7.4×10-5), particularly among those with evidence of usual interstitial pneumonia on high-resolution computed tomography (adjusted odds ratio in combined analysis, 6.1; 95% CI, 2.9 to 13.1; P=2.5×10-6). However, no significant association with the MUC5B promoter variant was observed for the diagnosis of RA alone.ConclusionsWe found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging. (Funded by Société Française de Rhumatologie and others.).

Published
2018

10. Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank

Author

Loganathan, Aravinthan, primary, Zanframundo, Giovanni, additional, Yoshida, Akira, additional, Faghihi-Kashani, Sara, additional, Bauer Ventura, Iazsmin, additional, Dourado, Eduardo, additional, Bozan, Francisca, additional, Sambataro, Gianluca, additional, Yamano, Yasuhiko, additional, Bae, Sharon Sangmee, additional, Lim, Darosa, additional, Ceribelli, Angela, additional, Isailovic, Natasa, additional, Selmi, Carlo, additional, Fertig, Noreen, additional, Bravi, Elena, additional, Kaneko, Yuko, additional, Saraiva, André Pinto, additional, Jovani, Vega, additional, Bachiller-Corral, Javier, additional, Cifrian, Jose, additional, Mera-Varela, Antonio, additional, Moghadam-Kia, Siamak, additional, Wolff, Veronica, additional, Campagne, Julien, additional, Meyer, Alain, additional, Giannini, Margherita, additional, Triantafyllias, Konstantinos, additional, Knitza, Johannes, additional, Gupta, Latika, additional, Molad, Yair, additional, Iannone, Florenzo, additional, Cavazzana, Ilaria, additional, Piga, Matteo, additional, De Luca, Giacomo, additional, Tansley, Sarah, additional, Bozzalla-Cassione, Emanuele, additional, Bonella, Francesco, additional, Corte, Tamera J., additional, Doyle, Tracy J., additional, Fiorentino, David, additional, Gonzalez-Gay, Miguel Angel, additional, Hudson, Marie, additional, Kuwana, Masataka, additional, Lundberg, Ingrid E., additional, Mammen, Andrew L., additional, McHugh, Neil John, additional, Miller, Fredrick W., additional, Montecucco, Carlomaurizio, additional, Oddis, Chester V., additional, Rojas-Serrano, Jorge, additional, Schmidt, Jens, additional, Scirè, Carlo Alberto, additional, Selva-O'Callaghan, Albert, additional, Werth, Victoria P., additional, Alpini, Claudia, additional, Bozzini, Sara, additional, Cavagna, Lorenzo, additional, and Aggarwal, Rohit, additional

Published
2024
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11. The type 2 inflammatory response favors recognition of tumor antigens by IgE in breast cancer

Author

Ramos‐Martinez, Espiridión, primary, García‐Vazquez, Francisco Javier, additional, Falfán‐Valencia, Ramcés, additional, Rojas‐Serrano, Jorge, additional, Alfaro‐Cruz, Ana, additional, Pérez‐Villaseñor, Marcela, additional, Aristi‐Urista, Gerardo, additional, Pérez‐Hernández, Jesús, additional, López‐Vancell, Rosario, additional, Velasco‐Medina, Andrea, additional, and Velázquez‐Sámano, Guillermo, additional

Published
2024
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12. Characteristics and risk factors of COVID-19 breakthrough infections in Idiopathic Inflammatory Myopathies: Results from the COVAD study

Author

Hoff, Leonardo Santos; https://orcid.org/0000-0002-2083-4796, Naveen, Ravichandran; https://orcid.org/0000-0003-2014-3925, Sen, Parikshit; https://orcid.org/0000-0002-1630-6026, Day, Jessica; https://orcid.org/0000-0001-8528-4361, Joshi, Mrudula; https://orcid.org/0000-0001-7312-351X, Nune, Arvind; https://orcid.org/0000-0002-3849-614X, Nikiphorou, Elena; https://orcid.org/0000-0001-6847-3726, Saha, Sreoshy; https://orcid.org/0000-0001-6745-9770, Tan, Ai Lyn; https://orcid.org/0000-0002-9158-7243, Shinjo, Samuel Katsuyuki; https://orcid.org/0000-0002-3682-4517, Ziade, Nelly; https://orcid.org/0000-0002-4479-7678, Velikova, Tsvetelina; https://orcid.org/0000-0002-0593-1272, Milchert, Marcin; https://orcid.org/0000-0002-0943-8768, Jagtap, Kshitij; https://orcid.org/0000-0003-2729-737X, Parodis, Ioannis; https://orcid.org/0000-0002-4875-5395, Edgar Gracia-Ramos, Abraham; https://orcid.org/0000-0003-1842-2554, Cavagna, Lorenzo; https://orcid.org/0000-0003-3292-1528, Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Knitza, Johannes; https://orcid.org/0000-0001-9695-0657, Chen, Yi Ming; https://orcid.org/0000-0001-7593-3065, Makol, Ashima; https://orcid.org/0000-0002-8748-898X, Agarwal, Vishwesh; https://orcid.org/0000-0002-0986-8354, Patel, Aarat, Pauling, John D; https://orcid.org/0000-0002-2793-2364, Wincup, Chris; https://orcid.org/0000-0002-8742-8311, Barman, Bhupen; https://orcid.org/0000-0002-5433-1310, Zamora Tehozol, Erick Adrian; https://orcid.org/0000-0002-7888-3961, Rojas Serrano, Jorge; https://orcid.org/0000-0001-6980-7898, García-De La Torre, Ignacio; https://orcid.org/0000-0002-9261-678X, Colunga-Pedraza, Iris J; https://orcid.org/0000-0002-2786-5843, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, Saavedra, Miguel A; https://orcid.org/0000-0003-0687-9944, Chinoy, Hector; https://orcid.org/0000-0001-6492-1288, Agarwal, Vikas; https://orcid.org/0000-0002-4508-1233, Aggarwal, Rohit; https://orcid.org/0000-0001-7531-8038, Gupta, Latika; https://orcid.org/0000-0003-2753-2990, Hoff, Leonardo Santos; https://orcid.org/0000-0002-2083-4796, Naveen, Ravichandran; https://orcid.org/0000-0003-2014-3925, Sen, Parikshit; https://orcid.org/0000-0002-1630-6026, Day, Jessica; https://orcid.org/0000-0001-8528-4361, Joshi, Mrudula; https://orcid.org/0000-0001-7312-351X, Nune, Arvind; https://orcid.org/0000-0002-3849-614X, Nikiphorou, Elena; https://orcid.org/0000-0001-6847-3726, Saha, Sreoshy; https://orcid.org/0000-0001-6745-9770, Tan, Ai Lyn; https://orcid.org/0000-0002-9158-7243, Shinjo, Samuel Katsuyuki; https://orcid.org/0000-0002-3682-4517, Ziade, Nelly; https://orcid.org/0000-0002-4479-7678, Velikova, Tsvetelina; https://orcid.org/0000-0002-0593-1272, Milchert, Marcin; https://orcid.org/0000-0002-0943-8768, Jagtap, Kshitij; https://orcid.org/0000-0003-2729-737X, Parodis, Ioannis; https://orcid.org/0000-0002-4875-5395, Edgar Gracia-Ramos, Abraham; https://orcid.org/0000-0003-1842-2554, Cavagna, Lorenzo; https://orcid.org/0000-0003-3292-1528, Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Knitza, Johannes; https://orcid.org/0000-0001-9695-0657, Chen, Yi Ming; https://orcid.org/0000-0001-7593-3065, Makol, Ashima; https://orcid.org/0000-0002-8748-898X, Agarwal, Vishwesh; https://orcid.org/0000-0002-0986-8354, Patel, Aarat, Pauling, John D; https://orcid.org/0000-0002-2793-2364, Wincup, Chris; https://orcid.org/0000-0002-8742-8311, Barman, Bhupen; https://orcid.org/0000-0002-5433-1310, Zamora Tehozol, Erick Adrian; https://orcid.org/0000-0002-7888-3961, Rojas Serrano, Jorge; https://orcid.org/0000-0001-6980-7898, García-De La Torre, Ignacio; https://orcid.org/0000-0002-9261-678X, Colunga-Pedraza, Iris J; https://orcid.org/0000-0002-2786-5843, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, Saavedra, Miguel A; https://orcid.org/0000-0003-0687-9944, Chinoy, Hector; https://orcid.org/0000-0001-6492-1288, Agarwal, Vikas; https://orcid.org/0000-0002-4508-1233, Aggarwal, Rohit; https://orcid.org/0000-0001-7531-8038, and Gupta, Latika; https://orcid.org/0000-0003-2753-2990

Abstract

OBJECTIVES To explore prevalence, characteristics and risk factors of COVID-19 breakthrough infections (BIs) in idiopathic inflammatory myopathies (IIM) using data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. METHODS A validated patient self-reporting e-survey was circulated by the COVAD study group to collect data on COVID-19 infection and vaccination in 2022. BIs were defined as COVID-19 occurring ≥14 days after 2 vaccine doses. We compared BIs characteristics and severity among IIMs, other autoimmune rheumatic and non-rheumatic diseases (AIRD, nrAID), and healthy controls (HC). Multivariable Cox regression models assessed the risk factors for BI, severe BI and hospitalisations among IIMs. RESULTS Among 9449 included response, BIs occurred in 1447 (15.3%) respondents, median age 44 years (IQR 21), 77.4% female, and 182 BIs (12.9%) occurred among 1406 IIMs. Multivariable Cox regression among IIMs showed age as a protective factor for BIs [Hazard Ratio (HR)=0.98, 95%CI = 0.97-0.99], hydroxychloroquine and sulfasalazine use were risk factors (HR = 1.81, 95%CI = 1.24-2.64, and HR = 3.79, 95%CI = 1.69-8.42, respectively). Glucocorticoid use was a risk factor for severe BI (HR = 3.61, 95%CI = 1.09-11.8). Non-White ethnicity (HR = 2.61, 95%CI = 1.03-6.59) was a risk factor for hospitalisation. Compared with other groups, patients with IIMs required more supplemental oxygen therapy (IIM = 6.0% vs AIRD = 1.8%, nrAID = 2.2%, and HC = 0.9%), intensive care unit admission (IIM = 2.2% vs AIRD = 0.6%, nrAID, and HC = 0%), advanced treatment with antiviral or monoclonal antibodies (IIM = 34.1% vs AIRD = 25.8%, nrAID = 14.6%, and HC = 12.8%), and had more hospitalisation (IIM = 7.7% vs AIRD = 4.6%, nrAID = 1.1%, and HC = 1.5%). CONCLUSION Patients with IIMs are susceptible to severe COVID-19 BI. Age and immunosuppressive treatments were related to the risk of BIs.

Published
2024

15. Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population

Author

Nava-Quiroz, Karol J., primary, Rojas-Serrano, Jorge, additional, Pérez-Rubio, Gloria, additional, Buendia-Roldan, Ivette, additional, Mejía, Mayra, additional, Fernández-López, Juan Carlos, additional, Ramos-Martínez, Espiridión, additional, López-Flores, Luis A., additional, Del Ángel-Pablo, Alma D., additional, and Falfán-Valencia, Ramcés, additional

Published
2023
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17. Lung microbiome alterations in patients with anti-Jo1 antisynthetase syndrome and interstitial lung disease

Author

Quintero-Puerta, Teresa, primary, Lira-Lucio, Juan Alberto, additional, Falfán-Valencia, Ramcés, additional, Vega-Sánchez, Ángel E., additional, Márquez-García, Eduardo, additional, Mejía, Mayra, additional, Bautista-Becerril, Brandon, additional, Rojas-Serrano, Jorge, additional, Ramos-Martínez, Espiridión, additional, Buendía-Roldán, Ivette, additional, and Pérez-Rubio, Gloria, additional

Published
2023
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19. Evaluation of pro-inflammatory proteins and joint disease activity in individuals with interstitial lung disease associated with rheumatoid arthritis.

Author

Nava Quiroz, Karol Jazmin, primary, Rojas-Serrano, Jorge, additional, Ramos-Martínez, Espiridión, additional, Mejía, Mayra, additional, Pérez-Rubio, Gloria, additional, Buendía-Roldán, Ivette, additional, Rodríguez-Henríquez, Pedro, additional, and Falfán-Valencia, Ramcés, additional

Published
2023
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20. Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients

Author

Nava-Quiroz, Karol J., primary, Rojas-Serrano, Jorge, additional, Pérez-Rubio, Gloria, additional, Buendia-Roldan, Ivette, additional, Mejía, Mayra, additional, Fernández-López, Juan Carlos, additional, Rodríguez-Henríquez, Pedro, additional, Ayala-Alcantar, Noé, additional, Ramos-Martínez, Espiridión, additional, López-Flores, Luis Alberto, additional, Del Ángel-Pablo, Alma D., additional, and Falfán-Valencia, Ramcés, additional

Published
2023
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24. Single-Nucleotide Variants in PADI2 and PADI4 and Ancestry Informative Markers in Interstitial Lung Disease and Rheumatoid Arthritis among a Mexican Mestizo Population.

Author

Nava-Quiroz, Karol J., Rojas-Serrano, Jorge, Pérez-Rubio, Gloria, Buendia-Roldan, Ivette, Mejía, Mayra, Fernández-López, Juan Carlos, Ramos-Martínez, Espiridión, López-Flores, Luis A., Del Ángel-Pablo, Alma D., and Falfán-Valencia, Ramcés

Subjects
INTERSTITIAL lung diseases, RHEUMATOID arthritis, MEXICANS, LUNGS, SINGLE nucleotide polymorphisms, ARGININE deiminase
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs being one of the affected areas. Among these, damage to the pulmonary interstitium (Interstitial Lung Disease—ILD) has been linked to proteins involved in the inflammatory process and related to extracellular matrix deposition and lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role in this context. A genetic association analysis was conducted on genes encoding two PAD isoforms: PAD2 and PAD4. This analysis also included ancestry informative markers and protein level determination in samples from patients with RA, RA-associated ILD, and clinically healthy controls. Significant single nucleotide variants (SNV) and one haplotype were identified as susceptibility factors for RA-ILD development. Elevated levels of PAD4 were found in RA-ILD cases, while PADI2 showed an association with RA susceptibility. This work presents data obtained from previously published research. Population variability has been noticed in genetic association studies. We present data for 14 SNVs that show geographical and genetic variation across the Mexican population, which provides highly informative content and greater intrapopulation genetic diversity. Further investigations in the field should be considered in addition to AIMs. The data presented in this study were analyzed in association with SNV genotypes in PADI2 and PADI4 to assess susceptibility to ILD in RA, as well as with changes in PAD2 and PAD4 protein levels according to carrier genotype, in addition to the use of covariates such as ancestry markers. Dataset: DOI 10.3390/cells12182235 (published manuscript.). The datasets generated for this study can be found in ClinVar accessions SCV001422427–SCV001422434. Dataset License: Attribution 4.0 International (CC BY 4.0) [ABSTRACT FROM AUTHOR]

Published
2024
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26. Flares after COVID-19 infection in patients with idiopathic inflammatory myopathies: results from the COVAD study

Author

Ali, Sasha Saadia, R, Naveen, Sen, Parikshit, Day, Jessica, Joshi, Mrudula, Nune, Arvind, Nikiphorou, Elena, Saha, Sreoshy, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Ziade, Nelly, Velikova, Tsvetelina, Milchert, Marcin, Jagtap, Kshitij, Parodis, Ioannis, Gracia-Ramos, Abraham Edgar, Cavagna, Lorenzo, Kuwana, Masataka, Knitza, Johannes, Chen, Yi Ming, Makol, Ashima, Agarwal, Vishwesh, Patel, Aarat, Pauling, John D, Wincup, Chris, Barman, Bhupen, Zamora Tehozol, Erick Adrian, Rojas Serrano, Jorge, La Torre, Ignacio García-De, Colunga-Pedraza, Iris J, et al, Distler, Oliver, and University of Zurich

Subjects
10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health
Published
2023

28. Enhanced Activity of NLRP3 Inflammasome in the Lung of Patients with Anti-Synthetase Syndrome

Author

Ramos-Martinez, Espiridión, primary, Vega-Sánchez, Angel E., additional, Pérez-Rubio, Gloria, additional, Mejia, Mayra, additional, Buendía-Roldán, Ivette, additional, González-Pérez, Montserrat I., additional, Mateos-Toledo, Heidegger N., additional, Andrade, Warrison A., additional, Falfán-Valencia, Ramcés, additional, and Rojas-Serrano, Jorge, additional

Published
2022
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30. Interstitial lung disease progression in patients with anti-aminoacyl transfer-RNA-synthetase autoantibodies is characterized by higher levels of sCD163

Author

Ramos-Martínez, Espiridión, primary, Falfán-Valencia, Ramcés, additional, Pérez-Rubio, Gloria, additional, Mejía, Mayra, additional, Mejía-Hurtado, José Guillermo, additional, Buendía-Roldán, Ivette, additional, González-Pérez, Montserrat I., additional, Mateos-Toledo, Heidegger N., additional, and Rojas-Serrano, Jorge, additional

Published
2022
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33. SERPINE1 rs6092 Variant Is Related to Plasma Coagulation Proteins in Patients with Severe COVID-19 from a Tertiary Care Hospital

Author

Fricke-Galindo, Ingrid, primary, Buendia-Roldan, Ivette, additional, Chavez-Galan, Leslie, additional, Pérez-Rubio, Gloria, additional, Hernández-Zenteno, Rafael de Jesús, additional, Ramos-Martinez, Espiridión, additional, Zazueta-Márquez, Armando, additional, Reyes-Melendres, Felipe, additional, Alarcón-Dionet, Aimé, additional, Guzmán-Vargas, Javier, additional, Bravo-Gutiérrez, Omar Andrés, additional, Quintero-Puerta, Teresa, additional, Gutiérrez-Pérez, Ilse Adriana, additional, Ortega-Martínez, Alejandro, additional, Ambrocio-Ortiz, Enrique, additional, Nava-Quiroz, Karol J., additional, Bañuelos-Flores, José Luis, additional, Jaime-Capetillo, María Esther, additional, Mejía, Mayra, additional, Rojas-Serrano, Jorge, additional, and Falfán-Valencia, Ramcés, additional

Published
2022
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34. TNFRSF1B and TNF Variants Are Associated With Differences in Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Severe COVID-19

Author

Fricke-Galindo, Ingrid, primary, Buendía-Roldán, Ivette, additional, Ruiz, Andy, additional, Palacios, Yadira, additional, Pérez-Rubio, Gloria, additional, de Jesus Hernández-Zenteno, Rafael, additional, Reyes-Melendres, Felipe, additional, Zazueta-Márquez, Armando, additional, Alarcón-Dionet, Aimé, additional, Guzmán-Vargas, Javier, additional, Bravo-Gutiérrez, Omar Andrés, additional, Quintero-Puerta, Teresa, additional, Gutiérrez-Pérez, Ilse Adriana, additional, Nava-Quiroz, Karol J, additional, Bañuelos-Flores, José Luis, additional, Mejía, Mayra, additional, Rojas-Serrano, Jorge, additional, Ramos-Martínez, Espiridión, additional, Guzmán-Guzmán, Iris Paola, additional, Chávez-Galán, Leslie, additional, and Falfán-Valencia, Ramcés, additional

Published
2022
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35. Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies

Author

Cavagna, Lorenzo, primary, Meloni, Federica, additional, Meyer, Alain, additional, Sambataro, Gianluca, additional, Belliato, Mirko, additional, De Langhe, Ellen, additional, Cavazzana, Ilaria, additional, Pipitone, Nicolò, additional, Triantafyllias, Konstantinos, additional, Mosca, Marta, additional, Barsotti, Simone, additional, Zampogna, Giuseppe, additional, Biglia, Alessandro, additional, Emmi, Giacomo, additional, De Visser, Marianne, additional, Van Der Kooi, Anneke, additional, Parronchi, Paola, additional, Hirschi, Sandrine, additional, da Silva, Jose Antonio Pereira, additional, Scirè, Carlo Alberto, additional, Furini, Federica, additional, Giannini, Margherita, additional, Martinez Gonzalez, Olga, additional, Damian, Laura, additional, Piette, Yves, additional, Smith, Vanessa, additional, Mera-Valera, Antonio, additional, Bachiller-Corral, Javier, additional, Cabezas Rodriguez, Ivan, additional, Brandy-Garcia, Anahy M., additional, Maurier, François, additional, Perrin, Julie, additional, Gonzalez-Moreno, Juan, additional, Drott, Ulrich, additional, Delbruck, Christiane, additional, Schwarting, Andreas, additional, Arrigoni, Eugenio, additional, Sebastiani, Gian Domenico, additional, Iuliano, Annamaria, additional, Nannini, Carlotta, additional, Quartuccio, Luca, additional, Rodriguez Cambron, Ana B., additional, Blázquez Cañamero, Maria Á., additional, Villa Blanco, Ignacio, additional, Cagnotto, Giovanni, additional, Pesci, Alberto, additional, Luppi, Francesco, additional, Dei, Giulia, additional, Romero Bueno, Fredeswinda Isabel, additional, Franceschini, Franco, additional, Chiapparoli, Ilaria, additional, Zanframundo, Giovanni, additional, Lettieri, Sara, additional, De Stefano, Ludovico, additional, Cutolo, Maurizio, additional, Mathieu, Alessandro, additional, Piga, Matteo, additional, Prieto-González, Sergio, additional, Moraes-Fontes, Maria Francisca, additional, Fonseca, Joao Eurico, additional, Jovani, Vega, additional, Riccieri, Valeria, additional, Santaniello, Alessandro, additional, Montfort, Stephen, additional, Bilocca, David, additional, Erre, Gian Luca, additional, Bartoloni, Elena, additional, Gerli, Roberto, additional, Monti, M. Cristina, additional, Lorenz, Hanns M., additional, Sambataro, Domenico, additional, Bellando Randone, Silvia, additional, Schneider, Udo, additional, Valenzuela, Claudia, additional, Lopez-Mejias, Raquel, additional, Cifrian, Jose, additional, Mejia, Mayra, additional, Gonzalez Perez, Monserrat-Ixchel, additional, Wendel, Sarah, additional, Fornaro, Marco, additional, De Luca, Giacomo, additional, Orsolini, Giovanni, additional, Rossini, Maurizio, additional, Dieude, Philippe, additional, Knitza, Johannes, additional, Castañeda, Santos, additional, Voll, Reinhard E., additional, Rojas-Serrano, Jorge, additional, Valentini, Adele, additional, Vancheri, Carlo, additional, Matucci-Cerinic, Marco, additional, Feist, Eugen, additional, Codullo, Veronica, additional, Iannone, Florenzo, additional, Distler, Jorg H., additional, Montecucco, Carlomaurizio, additional, and Gonzalez-Gay, Miguel A., additional

Published
2022
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36. Defining anti-synthetase syndrome: a systematic literature review

Author

Zanframundo, Giovanni, primary, Faghihi-Kashani, Sara, additional, Scirè, Carlo Alberto, additional, Bonella, Francesco, additional, Corte, Tamera J., additional, Doyle, Tracy J., additional, Fiorentino, David, additional, Gonzalez-Gay, Miguel A., additional, Hudson, Marie, additional, Kuwana, Masataka, additional, Lundberg, Ingrid E., additional, Mammen, Andrew, additional, McHugh, Neil, additional, Miller, Frederick W., additional, Monteccucco, Carlomaurizio, additional, Oddis, Chester V., additional, Rojas-Serrano, Jorge, additional, Schmidt, Jens, additional, Selva-O'Callaghan, Albert, additional, Werth, Victoria P., additional, Sakellariou, Garifallia, additional, Aggarwal, Rohit, additional, and Cavagna, Lorenzo, additional

Published
2022
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39. Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2

Author

Ramos-Martinez, Espiridión, primary, Falfán-Valencia, Ramcés, additional, Pérez-Rubio, Gloria, additional, Andrade, Warrison Athanasio, additional, Rojas-Serrano, Jorge, additional, Ambrocio-Ortiz, Enrique, additional, Galicia-Álvarez, Dennisse S., additional, Bárcenas-Montiel, Isaac, additional, Velasco-Medina, Andrea, additional, and Velázquez-Sámano, Guillermo, additional

Published
2021
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41. Enhanced Activity of NLRP3 Inflammasome in the Lung of Patients with Anti-Synthetase Syndrome.

Author

Ramos-Martinez, Espiridión, Vega-Sánchez, Angel E., Pérez-Rubio, Gloria, Mejia, Mayra, Buendía-Roldán, Ivette, González-Pérez, Montserrat I., Mateos-Toledo, Heidegger N., Andrade, Warrison A., Falfán-Valencia, Ramcés, and Rojas-Serrano, Jorge

Subjects
INFLAMMASOMES, NLRP3 protein, INTERSTITIAL lung diseases, LUNGS, CASPASES, TRANSFER RNA
Abstract

Anti-synthetase syndrome (ASSD) is an autoimmune disorder characterized by inflammatory interstitial lung disease (ILD). The main objective of this work was to quantify the concentrations of cytokines and molecules associated with inflammasome activation in bronchoalveolar lavage (BAL) of patients with ASSD and a comparison group of systemic sclerosis (SSc) patients. Cytokines and lactate dehydrogenase (LDH) were determined using the concentrated BAL protein. The activity of caspase-1 and concentration of NLRP3 with the protein purified from the cell pellet in each group of patients. We found higher caspase-1 levels in ASSD vs. SSc, 1.25 RFU vs. 0.75 RFU p = 0.003, and LDH levels at 0.15 OD vs. 0.09 OD p < 0.001. A significant difference was observed in molecules associated with inflammasome activation, IL-18: 1.42 pg/mL vs. 0.87 pg/mL p = 0.02 and IFN-γ: 0.9 pg/mL vs. 0.86 pg/mL, p = 0.01. A positive correlation was found between caspase-1 and LDH in the patients with ASSD Rho 0.58 (p = 0.008) but not in the SSc group. In patients with ASSD, greater caspase-1 and higher LDH activity were observed in BAL, suggesting cell death due to pyroptosis and activation of the inflammasome pathway. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Author

Ambrocio-Ortiz, Enrique, primary, Pérez-Rubio, Gloria, additional, Del Ángel-Pablo, Alma, additional, Buendía-Roldán, Ivette, additional, Chávez-Galán, Leslie, additional, Hernández-Zenteno, Rafael, additional, Ramírez-Venegas, Alejandra, additional, Rojas-Serrano, Jorge, additional, Mejía, Mayra, additional, Pérez-Padilla, Rogelio, additional, Guadarrama-Pérez, Cristóbal, additional, and Falfán-Valencia, Ramcés, additional

Published
2021
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48. Molecular analysis of phenotypic interactions of asthma

Author

Ramos-Martínez, Espiridión, primary, Rojas-Serrano, Jorge, additional, Andrade, Warrison, additional, Rojas-Bernabé, Araceli, additional, Falfán-Valencia, Ramcés, additional, Pérez-Rubio, Gloria, additional, Campos-Gutierrez, Rosa, additional, Cruz-Pantoja, Rubén, additional, Velasco-Medina, Andrea, additional, and Velázquez-Sámano, Guillermo, additional

Published
2021
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50. MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression

Author

Juge, Pierre-Antoine Solomon, Joshua J. van Moorsel, Coline H. M. Garofoli, Romain Lee, Joyce S. Louis-Sydney, Fabienne and Rojas-Serrano, Jorge Gonzalez-Perez, I, Montserrat Mejia, Mayra and Buendia-Roldan, Ivette Falfan-Valencia, Ramces and Ambrocio-Ortiz, Enrique Manali, Effrosyni Papiris, Spyros A. and Karageorgas, Theofanis Boumpas, Dimitrios Antoniou, Katarina M. and Sidiropoulos, Prodromos Trachalaki, Athina Van der Vis, Joanne J. Jamnitski, Anna Grutters, Jan C. Kannengiesser, Caroline Borie, Raphael Kawano-Dourado, Leticia and Wemeau-Stervinou, Lidwine Flipo, Rene-Marc Nunes, Hilario and Uzunhan, Yurdagul Valeyre, Dominique Saidenberg-Kermanac'h, Nathalie Boissier, Marie-Christophe Richez, Christophe and Schaeverbeke, Thierry Doyle, Tracy Wolters, Paul J. Debray, Marie-Pierre Boileau, Catherine Porcher, Raphael Schwartz, David A. Crestani, Bruno Dieude, Philippe

Subjects
respiratory system, respiratory tract diseases
Abstract

Background: The major risk factor for idiopathic pulmonary fibrosis (IPF), MUC5B rs35705950, was found to be associated with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Whilst the MUC5B rs35705950 T risk allele has been associated with better survival in IPF, its impact on RA-ILD prognosis remains to be determined. Our objective was to explore the influence of MUC5B rs35705950 on survival and progression in RA-ILD. Methods: Through an international retrospective observational study, patients with RA-ILD were genotyped for the MUC5B rs35705950 variant and consecutive pulmonary function tests (PFTs) findings were collected. Longitudinal data up to a 10-year follow-up were considered and analyzed using mixed regression models. Proportional hazards and joint proportional hazards models were used to analyze the association of baseline and longitudinal variables with lung transplant-free survival. Significant progression of RA-ILD was defined as at least an absolute or relative 10% decline of forced vital capacity at 2 years from baseline. Results: Out of 321 registered patients, 261 were included in the study: 139 women (53.3%), median age at RA-ILD diagnosis 65 years (interquartile range [IQR] 57 to 71), 151 ever smokers (59.2%). Median follow-up was 3.5 years (IQR 1.3 to 6.6). Mortality rate was 32% (95%CI 19 to 42) at 10 years. The MUC5B rs35705950 variant did not impact lung transplant-free survival (HR for the T risk allele carriers=1.26; 95%CI 0.61 to 2.62; P=0.53). Decline in pulmonary function at 2 years was not influenced by MUC5B rs35705950 (OR=0.95; 95%CI 0.44 to 2.05; P=0.89), irrespective of the HRCT pattern. Conclusion: In this study, the MUC5B rs35705950 promoter variant did not influence transplant-free survival or decline in pulmonary function in patients with RA-ILD. (c) 2021 Published by Elsevier Inc.

Published
2021

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