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256 results on '"Rojo-Martínez, G"'

1. Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Author

García-Escobar, E., Valdés, S., Soriguer, F., Vendrell, J., Urrutia-Etxebarria, I. M., Maldonado-Araque, C., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González-Frutos, T., Gomis, R., Goday, A., García-Serrano, S., Galán-García, J. L., Castell, C., Bordiú, E., Badía, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Delgado, E., Chaves, F. J., Castaño, L., Calle-Pascual, A., Rojo-Martínez, G., and Franch-Nadal, J.

Published
2021
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3. Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study

Author

Rojo-Martínez, G., Valdés, S., Soriguer, F., Vendrell, J., Urrutia, I., Pérez, V., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González- Frutos, T., Gomis, R., Goday, A., García-Serrano, S., García-Escobar, E., Galán-García, J. L., Castell, C., Badía-Guillén, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Franch-Nadal, J., Delgado, E., Chaves, F. J., Castaño, L., and Calle-Pascual, A.

Published
2020
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6. Mediterranean Diet Adherence in Individuals with Prediabetes and Unknown Diabetes : The Di@bet.es Study

Author

Ortega, E., Franch, J., Castell, C., Goday, A., Ribas-Barba, L., Soriguer, F., Vendrell, J., Casamitjana, R., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Castaño, L., Catalá, M., Delgado, E., Gaztambide, S., Girbés, J., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Pascual-Manich, G., Rojo-Martínez, G., Serrano-Rios, M., Urrutía, I., Valdés, S., Vázquez, J. A., and Gomis, R.

Published
2013

7. Iodine intake in the adult population. Di@bet.es study

Author

Soriguer, F., García-Fuentes, E., Gutierrez-Repiso, C., Rojo-Martínez, G., Velasco, I., Goday, A., Bosch-Comas, A., Bordiú, E., Calle, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Serrano-Rios, M., Valdés, S., Vázquez, J.A., and Vendrell, J.

Published
2012
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9. Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

Author

Soriguer, F, Rojo-Martínez, G, Goday, A, Bosch-Comas, A, Bordiú, E, Caballero-Díaz, F, Calle-Pascual, A, Carmena, R, Casamitjana, R, Castaño, L, Castell, C, Catalá, M, Delgado, E, Franch, J, Gaztambide, S, Girbés, J, Gomis, R, Gutiérrez, G, López-Alba, A, Teresa Martínez-Larrad, M, Menéndez, E, Mora-Peces, I, Ortega, E, Pascual-Manich, G, Serrano-Rios, M, Urrutia, I, Valdés, S, Antonio Vázquez, J, and Vendrell, J

Published
2013
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10. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study

Author

Soriguer, F., Goday, A., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M. T., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Rojo-Martínez, G., Serrano-Rios, M., Valdés, S., Vázquez, J. A., and Vendrell, J.

Published
2012
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11. Risk factors associated with retinal vein occlusion

Author

Martínez, F., Furió, E., Fabiá, M. J., Pérez, A. V., González-Albert, V., Rojo-Martínez, G., Martínez-Larrad, M. T., Mena-Martín, F. J., Soriguer, F., Serrano-Ríos, M., Chaves, F. J., Martín-Escudero, J. C., Redón, J., and García-Fuster, M. J.

Published
2014
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23. Dairy Product Consumption and Metabolic Diseases in the Di@bet.es Study

Author

Lago-Sampedro A, García-Escobar E, Rubio-Martín E, Pascual-Aguirre N, Valdés S, Soriguer F, Goday A, Calle-Pascual A, Castell C, Menéndez E, Delgado E, Bordiú E, Castaño L, Franch-Nadal J, Girbés J, Chaves FJ, Gaztambide S, Rojo-Martínez G, and Olveira G

Published
2019

27. Reference Values for TSH may be Inadequate to Define Hypothyroidism in Persons with Morbid Obesity: Di@bet.es Study

Author

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, Gutiérrez-Repiso C, Garcia-Escobar E, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, Vendrell J, Chacón MR, Javier Chaves F, Soriguer F, and Rojo-Martínez G

Subjects
Adult, Aged, 80 and over, Male, Observer Variation, Adolescent, Thyrotropin, Middle Aged, Overweight, Thyroid Function Tests, Obesity, Morbid, Thyroxine, Young Adult, Cross-Sectional Studies, Hypothyroidism, Thinness, Reference Values, Spain, Prevalence, Humans, Triiodothyronine, Female, Aged, Autoantibodies
Abstract

Objective: To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on the classification of hypothyroidism. Methods: The study included 3,928 individuals free of thyroid disease (without previous thyroid disease, no interfering medications, TSH < 10 mu UI/mL and thyroid peroxidase antibodies [TPO Abs] < 50 IU/mL) who participated in a national, cross-sectional, population-based study and were representative of the adult population of Spain. Data gathered included clinical and demographic characteristics, physical examination, and blood and urine sampling. TSH, free thyroxine, free triiodothyronine, and TPO Ab were analyzed by electrochemiluminescence (E170, Roche Diagnostics, Basel, Switzerland). Results: The reference range (p2.5-97.5) for TSH was estimated as 0.6 to 4.8 mu UI/mL in the underweight category (BMI= 40). By using the reference criteria for the normal-weight population, the prevalence of high TSH levels increased threefold in the morbid obesity category (P < 0.01). Conclusions: Persons with morbid obesity might be inappropriately classified if the standard ranges of normality of TSH for the normal-weight population are applied to them.

Published
2017

28. The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study

Author

Mansego ML, De Marco G, Ivorra C, Lopez-Izquierdo R, Morcillo S, Rojo-Martínez G, González-Albert V, Martinez F, Soriguer F, Martín-Escudero JC, Redon J, and Chaves FJ

Subjects
Oxidative stress, Catechol-O-methyltransferase, Waist circumference, Abdominal obesity, Polymorphism, Thioredoxin, Vitamin E intake
Abstract

Background: Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. Methods: A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays. Results: The AO group had higher 8-Oxo-2'-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression. Conclusions: WC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO.

Published
2015

29. Enhanced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsaturated fatty acid load in familial hypercholesterolemia

Author

Cortes R, Martinez-Hervas S, Ivorra C, De Marco G, Gonzalez-Albert V, Rojo-Martínez G, Saez G, Carmena R, Ascaso JF, Real JT, and Chaves FJ

Subjects
Glutathione enzymes, Thioredoxin enzymes, Oxidative stress, mRNA, Familial hypercholesterolemia, Glutathione enzymes, Oral fat load test, Oxidative stress, Thioredoxin enzymes, mRNA, Familial hypercholesterolemia, lipids (amino acids, peptides, and proteins), Oral fat load test
Abstract

Objectives: Familial hypercholesterolemia (FH) is characterized by increased oxidative stress (OS) levels. In the postprandial state, lipids and lipoproteins modulate OS status through their impact on pro-oxidant and antioxidant mechanisms. The objective of this study was to evaluate in patients with FH the response to an unsaturated oral fat load test (OFLT) by analyzing the mRNA levels of genes involved in the glutathione and thioredoxin antioxidant systems. Design and Methods: We analyzed 14 FH patients and 20 normolipidemic and normoglycemic controls. In both groups, mRNA values of antioxidant enzyme genes (glutathione and thioredoxin systems) were determined at baseline and at 2, 4, 6, and 8 h after OFLT by real time PCR. Results: In the fasting state the mRNA levels of antioxidant enzymes GPX4 and the GSR, GSS, and GCLC enzymes (involved in glutathione regeneration and synthesis) and thioredoxin (TXN), were significantly increased in the FH group compared to the healthy controls. Some genes (GPX1 and GPX4) were increased at 4 h in both groups, but values for the rest of the antioxidant enzyme mRNAs were decreased in FH patients after 4 h from unsaturated OFLT and were increased in controls. Conclusions: We concluded that an OFLT with predominantly unsaturated fat has a different effect on postprandial antioxidant enzyme mRNA levels in controls than in FH patients. Increased antioxidant enzyme mRNA is not the main way to reduce postprandial oxidative stress in FH. This difference could determine the influence of dietary patterns in these patients. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Published
2014

31. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study

Author

Vendrell, J., Vázquez, J.A., Valdés, S., Serrano-Rios, M., Rojo-Martínez, G., Pascual-Manich, G., Ortega, E., Mora-Peces, I., Menéndez, E., Martínez-Larrad, M.T., López-Alba, A., Gutiérrez, G., Gomis, R., Girbés, J., Gaztambide, S., Franch, J., Delgado, E., Catalá, M., Castell, C., Castaño, L., Casamitjana, R., Carmena, R., Bordiú, E., Bosch-Comas, A., Goday, A., Soriguer, F., Runkle, I., Fuentes, M., Calle-Pascual, A.L., Marcuello, C., Medicina i Cirurgia, and Universitat Rovira i Virgili.

Subjects
1687-8337, humanities
Abstract

10.1155/2012/872305 Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results. Mean PCS-12/MCS-12 values were /, respectively. Men had higher scores than women in both PCS-12 ( versus ; ) and MCS-12 ( versus ; ). Increasing age and obesity were associated with a poorer PCS-12 score. In women lower PCS-12 and MCS-12 scores were associated with a higher level of glucose metabolism abnormality (prediabetes and diabetes), ( for trend), but only the PCS-12 score was associated with altered glucose levels in men ( for trend). The Odds Ratio adjusted for age, body mass index (BMI) and educational level, for a PCS-12 score below the median was 1.62 (CI 95%: 1.2–2.19; ) for men with KDM and 1.75 for women with KDM (CI 95%: 1.26–2.43; ), respectively. Conclusion. Current study indicates that increasing levels of altered carbohydrate metabolism are accompanied by a trend towards decreasing quality of life, mainly in women, in a representative sample of Spanish population.

Published
2012
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33. Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene–diet interactions

Author

Fernández-Real, J M, primary, Corella, D, additional, Goumidi, L, additional, Mercader, J M, additional, Valdés, S, additional, Rojo Martínez, G, additional, Ortega, F, additional, Martinez-Larrad, M-T, additional, Gómez-Zumaquero, J M, additional, Salas-Salvadó, J, additional, Martinez González, M A, additional, Covas, M I, additional, Botas, P, additional, Delgado, E, additional, Cottel, D, additional, Ferrieres, J, additional, Amouyel, P, additional, Ricart, W, additional, Ros, E, additional, Meirhaeghe, A, additional, Serrano-Rios, M, additional, Soriguer, F, additional, and Estruch, R, additional

Published
2013
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34. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)

Author

Marcuello, C., primary, Calle-Pascual, A. L., additional, Fuentes, M., additional, Runkle, I., additional, Soriguer, F., additional, Goday, A., additional, Bosch-Comas, A., additional, Bordiú, E., additional, Carmena, R., additional, Casamitjana, R., additional, Castaño, L., additional, Castell, C., additional, Catalá, M., additional, Delgado, E., additional, Franch, J., additional, Gaztambide, S., additional, Girbés, J., additional, Gomis, R., additional, Gutiérrez, G., additional, López-Alba, A., additional, Martínez-Larrad, M. T., additional, Menéndez, E., additional, Mora-Peces, I., additional, Ortega, E., additional, Pascual-Manich, G., additional, Rojo-Martínez, G., additional, Serrano-Rios, M., additional, Valdés, S., additional, Vázquez, J. A., additional, and Vendrell, J., additional

Published
2012
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35. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study

Author

Soriguer, F., primary, Goday, A., additional, Bosch-Comas, A., additional, Bordiú, E., additional, Calle-Pascual, A., additional, Carmena, R., additional, Casamitjana, R., additional, Castaño, L., additional, Castell, C., additional, Catalá, M., additional, Delgado, E., additional, Franch, J., additional, Gaztambide, S., additional, Girbés, J., additional, Gomis, R., additional, Gutiérrez, G., additional, López-Alba, A., additional, Martínez-Larrad, M. T., additional, Menéndez, E., additional, Mora-Peces, I., additional, Ortega, E., additional, Pascual-Manich, G., additional, Rojo-Martínez, G., additional, Serrano-Rios, M., additional, Valdés, S., additional, Vázquez, J. A., additional, and Vendrell, J., additional

Published
2011
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36. Children whose diet contained olive oil had a lower likelihood of increasing their body mass index Z-score over 1 year

Author

Haro-Mora, J J, primary, García-Escobar, E, additional, Porras, N, additional, Alcázar, D, additional, Gaztambide, J, additional, Ruíz-Órpez, A, additional, García-Serrano, S, additional, Rubio-Martín, E, additional, García-Fuentes, E, additional, López-Siguero, J P, additional, Soriguer, F, additional, and Rojo-Martínez, G, additional

Published
2011
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38. The −30G>A Polymorphism of the Glucokinase Gene Promoter Is Associated With Obesity in a Population From Southern Spain

Author

Gómez-Zumaquero, Juan M., primary, Rojo-Martínez, G., additional, García-Escobar, E., additional, Martín-Nuñez, Gracia M., additional, Haro, J., additional, Esteva, I., additional, de Adana, M. Ruiz, additional, Cuesta, Antonio L., additional, Olveira, G., additional, Morcillo, S., additional, and Soriguer, F., additional

Published
2008
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