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1. Author Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Millat-Martinez, Pere, Gharbharan, Arvind, Alemany, Andrea, Rokx, Casper, Geurtsvankessel, Corine, Papageorgiou, Grigorios, van Geloven, Nan, Jordans, Carlijn, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, Ellen, Corbacho-Monné, Marc, Ouchi, Dan, Piccolo Ferreira, Francini, Malchair, Pierre, Videla, Sebastian, García García, Vanesa, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodriguez Codina, Joana, Amado Simon, Rosa, Grifols, Joan-Ramon, Blanco, Julian, Blanco, Ignacio, Ara, Jordi, Bassat, Quique, Clotet, Bonaventura, Baro, Bàrbara, Troxel, Andrea, Zwaginga, Jaap Jan, Mitjà, Oriol, and Rijnders, Bart J. A.

Published
2024
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3. Unified European support framework to sustain the HIV cascade of care for people living with HIV including in displaced populations of war-struck Ukraine

Author

Vasylyev, Marta, Skrzat-Klapaczyńska, Agata, Bernardino, Jose I, Săndulescu, Oana, Gilles, Christine, Libois, Agnès, Curran, Adrian, Spinner, Christoph D, Rowley, Dominic, Bickel, Markus, Aichelburg, Maximilian C, Nozza, Silvia, Wensing, Annemarie, Barber, Tristan J, Waters, Laura, Jordans, Carlijn, Bramer, Wichor, Lakatos, Botond, Tovba, Lidia, Koval, Tetyana, Kyrychenko, Tetyana, Dumchev, Kostyantyn, Buhiichyk, Vira, Smyrnov, Pavlo, Antonyak, Svitlana, Antoniak, Sergii, Vasylyeva, Tetyana I, Mazhnaya, Alyona, Kowalska, Justyna, Bhagani, Sanjay, Rokx, Casper, and Investigators, European AIDS Clinical Society Young

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, HIV/AIDS, Prevention, Infectious Diseases, Infection, Peace, Justice and Strong Institutions, Europe, HIV Infections, Humans, Ukraine, European AIDS Clinical Society (EACS) Young Investigators, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Ukraine is one of the countries in Europe most affected by HIV. The escalation of open war on the European continent has affected HIV care in Ukraine in an unprecedented way. Treating physicians in Europe have little experience on how to handle HIV-specific care under these circumstances. A framework is urgently needed that both defines and sets out strategies to handle the specific challenges for emergency support for people living with HIV, both those staying in Ukraine and those becoming displaced. The optimal allocation of the few available medical resources, primarily antiretroviral therapy, is necessary to best prevent individual morbidity and achieve population transmission control. Professional HIV networks play a central role to create, optimise, and execute support strategies. Through a rapid literature review we identified the key strategies needed to create a support framework, adapted to Ukraine's HIV epidemiology. We produce a unified support framework aiming to reduce the inevitable impact on Ukraine's HIV care cascade now, and when rebuilding it after the war.

Published
2022

7. Outpatient convalescent plasma therapy for high-risk patients with early COVID-19: a randomized placebo-controlled trial

Author

Gharbharan, Arvind, Jordans, Carlijn, Zwaginga, Lisa, Papageorgiou, Grigorios, van Geloven, Nan, van Wijngaarden, Peter, den Hollander, Jan, Karim, Faiz, van Leeuwen-Segarceanu, Elena, Soetekouw, Robert, Lammers, Jolanda, Postma, Douwe, Kampschreur, Linda, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, C. Ellen, Götz, Hannelore, Haagmans, Bart, Koopmans, Marion, Bogers, Susanne, Geurtsvankessel, Corine, Zwaginga, Jaap Jan, Rokx, Casper, and Rijnders, Bart

Published
2023
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10. Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19

Author

Raadsen, Matthijs P., Gharbharan, Arvind, Jordans, Carlijn C. E., Mykytyn, Anna Z., Lamers, Mart M., van den Doel, Petra B., Endeman, Henrik, van den Akker, Johannes P. C., GeurtsvanKessel, Corine H., Koopmans, Marion P. G., Rokx, Casper, Goeijenbier, Marco, van Gorp, Eric C. M., Rijnders, Bart J. A., and Haagmans, Bart L.

Published
2022
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11. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Millat-Martinez, Pere, Gharbharan, Arvind, Alemany, Andrea, Rokx, Casper, Geurtsvankessel, Corine, Papageorgiou, Grigorios, van Geloven, Nan, Jordans, Carlijn, Groeneveld, Geert, Swaneveld, Francis, van der Schoot, Ellen, Corbacho-Monné, Marc, Ouchi, Dan, Piccolo Ferreira, Francini, Malchair, Pierre, Videla, Sebastian, García García, Vanesa, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodriguez Codina, Joana, Amado Simon, Rosa, Grifols, Joan-Ramon, Blanco, Julian, Blanco, Ignacio, Ara, Jordi, Bassat, Quique, Clotet, Bonaventura, Baro, Bàrbara, Troxel, Andrea, Zwaginga, Jaap Jan, Mitjà, Oriol, and Rijnders, Bart J. A.

Published
2022
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12. Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning

Author

Mueller, Yvonne M., Schrama, Thijs J., Ruijten, Rik, Schreurs, Marco W. J., Grashof, Dwin G. B., van de Werken, Harmen J. G., Lasinio, Giovanna Jona, Álvarez-Sierra, Daniel, Kiernan, Caoimhe H., Castro Eiro, Melisa D., van Meurs, Marjan, Brouwers-Haspels, Inge, Zhao, Manzhi, Li, Ling, de Wit, Harm, Ouzounis, Christos A., Wilmsen, Merel E. P., Alofs, Tessa M., Laport, Danique A., van Wees, Tamara, Kraker, Geoffrey, Jaimes, Maria C., Van Bockstael, Sebastiaan, Hernández-González, Manuel, Rokx, Casper, Rijnders, Bart J. A., Pujol-Borrell, Ricardo, and Katsikis, Peter D.

Published
2022
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13. Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study

Author

Vasylyev, Marta, primary, Wit, Ferdinand W N M, additional, Jordans, Carlijn C E, additional, Soetekouw, Robin, additional, van Lelyveld, Steven F L, additional, Kootstra, Gert-Jan, additional, Delsing, Corine E, additional, Ammerlaan, Heidi S M, additional, van Kasteren, Marjo E E, additional, Brouwer, Annemarie E, additional, Leyten, Eliane M S, additional, Claassen, Mark A A, additional, Hassing, Robert-Jan, additional, den Hollander, Jan G, additional, van den Berge, Marcel, additional, Roukens, Anna H E, additional, Bierman, Wouter F W, additional, Groeneveld, Paul H P, additional, Lowe, Selwyn H, additional, van Welzen, Berend J, additional, Richel, Olivier, additional, Nellen, Jeannine F, additional, van den Berk, Guido E L, additional, van der Valk, Marc, additional, Rijnders, Bart J A, additional, and Rokx, Casper, additional

Published
2024
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14. COVID-19 epidemiology and performance of the WHO clinical algorithm to diagnose COVID-19 in people with HIV from Ukraine

Author

Vasylyev, Marta, primary, Buhiichyk, Vira, additional, Buhiichyck, Nadiia, additional, Groenendijk, Albert, additional, Ben, Iryna, additional, Ostapiuk, Lesya, additional, Sluzhynska, Maryana, additional, Bierman, Wouter F.W., additional, van Kampen, Jeroen J.A., additional, Wit, Ferdinand W.N.M., additional, Reiss, Peter, additional, Rijnders, Bart J.A., additional, Sluzhynska, Oleksandra, additional, and Rokx, Casper, additional

Published
2024
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15. Systematic Review: Strategies for Improving HIV Testing and Detection Rates in European Hospitals

Author

Vliegenthart-Jongbloed, Klaske J., primary, Vasylyev, Marta, additional, Jordans, Carlijn C. E., additional, Bernardino, Jose I., additional, Nozza, Silvia, additional, Psomas, Christina K., additional, Voit, Florian, additional, Barber, Tristan J., additional, Skrzat-Klapaczyńska, Agata, additional, Săndulescu, Oana, additional, and Rokx, Casper, additional

Published
2024
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16. Correction: Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study

Author

Hensley, Kathryn S., Jongkees, Marlou J., Geers, Daryl, GeurtsvanKessel, Corine H., Mueller, Yvonne M., Dalm, Virgil A. S. H., Papageorgiou, Grigorios, Steggink, Hanka, Gorska, Alicja, Bogers, Susanne, den Hollander, Jan G., Bierman, Wouter F. W., Gelinck, Luc B. S., Schippers, Emile F., Ammerlaan, Heidi S. M., van der Valk, Marc, van Vonderen, Marit G. A., Delsing, Corine E., Gisolf, Elisabeth H., Bruns, Anke H. W., Lauw, Fanny N., Berrevoets, Marvin A. H., Sigaloff, Kim C. E., Soetekouw, Robert, Branger, Judith, de Mast, Quirijn, Lammers, Adriana J. J., Lowe, Selwyn H., de Vries, Rory D., Katsikis, Peter D., Rijnders, Bart J. A., Brinkman, Kees, Roukens, Anna H. E., and Rokx, Casper

Subjects
Biological sciences
Abstract

Author(s): Kathryn S. Hensley, Marlou J. Jongkees, Daryl Geers, Corine H. GeurtsvanKessel, Yvonne M. Mueller, Virgil A. S. H. Dalm, Grigorios Papageorgiou, Hanka Steggink, Alicja Gorska, Susanne Bogers, Jan G. [...]

Published
2023
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18. Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study

Author

Hensley, Kathryn S., Jongkees, Marlou J., Geers, Daryl, GeurtsvanKessel, Corine H., Mueller, Yvonne M., Dalm, Virgil A. S. H., Papageorgiou, Grigorios, Steggink, Hanka, Gorska, Alicja, Bogers, Susanne, den Hollander, Jan G., Bierman, Wouter F. W., Gelinck, Luc B. S., Schippers, Emile F., Ammerlaan, Heidi S. M., van der Valk, Marc, van Vonderen, Marit G. A., Delsing, Corine E., Gisolf, Elisabeth H., Bruns, Anke H. W., Lauw, Fanny N., Berrevoets, Marvin A. H., Sigaloff, Kim C. E., Soetekouw, Robert, Branger, Judith, de Mast, Quirijn, Lammers, Adriana J. J., Lowe, Selwyn H., de Vries, Rory D., Katsikis, Peter D., Rijnders, Bart J. A., Brinkman, Kees, Roukens, Anna H. E., and Rokx, Casper

Subjects
Immune response -- Evaluation -- Comparative analysis, HIV patients -- Drug therapy, Biological sciences
Abstract

Background Vaccines can be less immunogenic in people living with HIV (PLWH), but for SARS-CoV-2 vaccinations this is unknown. In this study we set out to investigate, for the vaccines currently approved in the Netherlands, the immunogenicity and reactogenicity of SARS-CoV-2 vaccinations in PLWH. Methods and findings We conducted a prospective cohort study to examine the immunogenicity of BNT162b2, mRNA-1273, ChAdOx1-S, and Ad26.COV2.S vaccines in adult PLWH without prior COVID-19, and compared to HIV-negative controls. The primary endpoint was the anti-spike SARS-CoV-2 IgG response after mRNA vaccination. Secondary endpoints included the serological response after vector vaccination, anti-SARS-CoV-2 T-cell response, and reactogenicity. Between 14 February and 7 September 2021, 1,154 PLWH (median age 53 [IQR 44-60] years, 85.5% male) and 440 controls (median age 43 [IQR 33-53] years, 28.6% male) were included in the final analysis. Of the PLWH, 884 received BNT162b2, 100 received mRNA-1273, 150 received ChAdOx1-S, and 20 received Ad26.COV2.S. In the group of PLWH, 99% were on antiretroviral therapy, 97.7% were virally suppressed, and the median CD4+ T-cell count was 710 cells/[mu]L (IQR 520-913). Of the controls, 247 received mRNA-1273, 94 received BNT162b2, 26 received ChAdOx1-S, and 73 received Ad26.COV2.S. After mRNA vaccination, geometric mean antibody concentration was 1,418 BAU/mL in PLWH (95% CI 1322-1523), and after adjustment for age, sex, and vaccine type, HIV status remained associated with a decreased response (0.607, 95% CI 0.508-0.725, p 300 BAU/mL, whilst in PLWH this response rate was 93.6%. In PLWH vaccinated with mRNA-based vaccines, higher antibody responses were predicted by CD4+ T-cell count 250-500 cells/[mu]L (2.845, 95% CI 1.876-4.314, p 500 cells/[mu]L (2.936, 95% CI 1.961-4.394, p 50 copies/mL was associated with a reduced response (0.454, 95% CI 0.286-0.720, p = 0.001). Increased IFN-[gamma], CD4+ T-cell, and CD8+ T-cell responses were observed after stimulation with SARS-CoV-2 spike peptides in ELISpot and activation-induced marker assays, comparable to controls. Reactogenicity was generally mild, without vaccine-related serious adverse events. Due to the control of vaccine provision by the Dutch National Institute for Public Health and the Environment, there were some differences between vaccine groups in the age, sex, and CD4+ T-cell counts of recipients. Conclusions After vaccination with BNT162b2 or mRNA-1273, anti-spike SARS-CoV-2 antibody levels were reduced in PLWH compared to HIV-negative controls. To reach and maintain the same serological responses as HIV-negative controls, additional vaccinations are probably required. Trial registration The trial was registered in the Netherlands Trial Register (NL9214). https://www.trialregister.nl/trial/9214., Author(s): Kathryn S. Hensley 1, Marlou J. Jongkees 1, Daryl Geers 2, Corine H. GeurtsvanKessel 2, Yvonne M. Mueller 3, Virgil A. S. H. Dalm 3,4, Grigorios Papageorgiou 5, Hanka [...]

Published
2022
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19. Perceptions of Rapid Antiretroviral Therapy Initiation Among Participants of The Netherlands Cohort Study on Acute HIV Infection.

Author

van Paassen, Pien, Dijkstra, Maartje, Peay, Holly L., Rokx, Casper, Verbon, Annelies, Reiss, Peter, Prins, Jan M., Henderson, Gail E., Rennie, Stuart, Nieuwkerk, Pythia T., and de Bree, Godelieve J.

Abstract

Starting antiretroviral therapy (ART) same-day, or as soon as possible after HIV diagnosis is advised in guidelines worldwide. Especially during acute HIV infection (AHI), rapid ART start may be more urgent because of a higher risk of transmission or symptoms of acute retroviral syndrome. During this phase, rapid ART start may have additional benefits for viral reservoir size and host immunity. We explored perceptions of rapid ART start among participants of The Netherlands Cohort Study on Acute HIV infection (NOVA study), who started ART rapidly after diagnosis of AHI. We conducted 20 in-depth qualitative interviews with NOVA study participants between October and December 2018. Data were analyzed thematically, using inductive and iterative coding techniques. Roughly half of the participants stated they felt well-informed about the importance of (rapid) ART. Starting ART rapidly was perceived positively by almost all participants, mostly because of the expected benefits on their health, and to prevent HIV transmission. Rapid ART start was seen as a way to cope with the diagnosis. However, a more negative perception was that rapid ART start confronted participants with their diagnosis, when they were still adjusting to a new situation. Our results show that among people diagnosed during AHI, rapid ART is well-accepted. These results should be encouraging to HIV care providers who encounter people with AHI in their clinical practice and to researchers who carry out cure-related studies, in which early ART is often included. The Clinical Trial Registration number is NCT05728996. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Analytical treatment interruption: detection of an increase in the latent, inducible HIV-1 reservoir more than a decade after viral resuppression

Author

Lungu, Cynthia, primary, Hossain, Tanvir, additional, Prins, Henrieke A.B., additional, Hensley, Kathryn S., additional, Crespo, Raquel, additional, Rokx, Casper, additional, Rao, Shringar, additional, van Kampen, Jeroen J.A., additional, van de Vijver, David A.M.C., additional, Mesplede, Thibault, additional, Katsikis, Peter D., additional, Mueller, Yvonne M., additional, Gruters, Rob A., additional, and Mahmoudi, Tokameh, additional

Published
2023
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22. Perceptions of Rapid Antiretroviral Therapy Initiation Among Participants of The Netherlands Cohort Study on Acute HIV Infection

Author

van Paassen, Pien, primary, Dijkstra, Maartje, additional, Peay, Holly L., additional, Rokx, Casper, additional, Verbon, Annelies, additional, Reiss, Peter, additional, Prins, Jan M., additional, Henderson, Gail E., additional, Rennie, Stuart, additional, Nieuwkerk, Pythia T., additional, and de Bree, Godelieve J., additional

Published
2023
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24. Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

Author

Gharbharan, Arvind, Jordans, Carlijn C. E., GeurtsvanKessel, Corine, den Hollander, Jan G., Karim, Faiz, Mollema, Femke P. N., Stalenhoef – Schukken, Janneke E., Dofferhoff, Anthonius, Ludwig, Inge, Koster, Adrianus, Hassing, Robert-Jan, Bos, Jeannet C., van Pottelberge, Geert R., Vlasveld, Imro N., Ammerlaan, Heidi S. M., van Leeuwen – Segarceanu, Elena M., Miedema, Jelle, van der Eerden, Menno, Schrama, Thijs J., Papageorgiou, Grigorios, te Boekhorst, Peter, Swaneveld, Francis H., Mueller, Yvonne M., Schreurs, Marco W. J., van Kampen, Jeroen J. A., Rockx, Barry, Okba, Nisreen M. A., Katsikis, Peter D., Koopmans, Marion P. G., Haagmans, Bart L., Rokx, Casper, and Rijnders, Bart J. A.

Published
2021
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25. Immune reconstitution inflammatory syndrome in HIV infected late presenters starting integrase inhibitor containing antiretroviral therapy

Author

Wijting, Ingeborg E.A., Wit, Ferdinand W.N.M., Rokx, Casper, Leyten, Eliane M.S., Lowe, Selwyn H., Brinkman, Kees, Bierman, Wouter F.W., van Kasteren, Marjo E.E., Postma, Anneloes M., Bloemen, Vera C.M., Bouchtoubi, Ghariba, Hoepelman, Andy I.M., van der Ende, Marchina E., Reiss, Peter, and Rijnders, Bart J.A.

Published
2019
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26. Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals

Author

Moldt, Brian, Günthard, Huldrych F., Workowski, Kimberly A., Little, Susan J., Eron, Joseph J., Overton, Edgar T., Lehmann, Clara, Rokx, Casper, Kozal, Michael J., Gandhi, Rajesh T., Braun, Dominique L., Parvangada, Aiyappa, Li, Jiani, Martin, Ross, Selzer, Lisa, Cox, Stephanie, Margot, Nicolas, Liu, Hui, Slamowitz, Debbie, Makadzange, Tariro, Collins, Sean E., Geleziunas, Romas, and Callebaut, Christian

Published
2022
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27. Second European Round Table on the Future Management of HIV: 10-11 October 2014, Barcelona, Spain.

Author

Rokx, Casper, Richman, Douglas D, Müller-Trutwin, Michaela, Silvestri, Guido, Lunzen, Jan, Khoo, Saye, Lichterfeld, Mathias, Altfeld, Marcus, Perno, Carlo Federico, Hunt, Peter W, Mallon, Paddy, Rockstroh, Jürgen K, Pozniak, Anton L, Clotet, Bonaventura, and Boucher, Charles Ab

Subjects
ART, HIV reservoir, HIV-1, HIV-1 cure, HIV-1 latency, animal models, gene therapy, inflammation, pharmacokinetics, primary HIV-1 infection, Infectious Diseases, HIV/AIDS, Stem Cell Research, Infection
Abstract

The Second European Round Table on the Future Management of HIV took place in Barcelona, 10-11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI). Important issues in the HIV-1 reservoir research field are the validity of reservoir measurement techniques and the potential of new drugs to target latently infected cells. Current HIV-1 cure concepts are based on theoretical assumptions of biologically plausible mechanisms, supported by several clinical observations. Three main potential strategies are under investigation in order to achieve a sterilising cure or maintain HIV-1 remission: latency reversal resulting in antigen expression and viral cytolysis or immune targeted cell-death; immunological control of the reservoir; or replacement of the complete autologous haematopoietic and lymphoid stem-cell repertoire by transplantation. An interesting opportunity for restricting the size of the reservoir entails the early initiation of antiretroviral treatment (ART) during PHI. In terms of the reservoir, early treatment limits its size, alters its composition, and restricts the genetic variability of integrated proviral HIV-1 DNA. The challenges ahead involve the identification of patients undergoing seroconversion to HIV-1 and the prompt initiation of treatment. How the seemingly beneficial impact of early treatment will make cure more feasible, and whether the positive effects of the cure efforts outweigh the potentially negative impact of life-long ART, are important aspects of future collaborative research prospects.

Published
2015

28. Incidence of a first venous thrombotic event in people with HIV in the Netherlands: a retrospective cohort study

Author

Van der Valk, M., Van Kasteren, M.E.E., Schippers, E.F., Leyten, E.M.S., Kroon, F.P., Den Hollander, J.G., Lowe, S.H., Mulder, J.W., Brinkman, K., Gisolf, E.H., Reiss, P., Zaheri, S., Hillebregt, M., van der Ende, M.E., Howard, Jaime F Borjas, Rokx, Casper, Smit, Colette, Wit, Ferdinand W N M, Pieterman, Elise D, Meijer, Karina, Rijnders, Bart, Bierman, Wouter F W, and Tichelaar, Y I G Vladimir

Published
2019
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31. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization

Author

Levine, Adam C, Fukuta, Yuriko, Huaman, Moises A, Ou, Jiangda, Meisenberg, Barry R, Patel, Bela, Paxton, James H, Hanley, Daniel F, Rijnders, Bart Ja, Gharbharan, Arvind, Rokx, Casper, Zwaginga, Jaap Jan, Alemany, Andrea, Mitjà, Oriol, Ouchi, Dan, Millat-Martinez, Pere, Durkalski-Mauldin, Valerie, Korley, Frederick K, Dumont, Larry J, Callaway, Clifton W, Libster, Romina, Marc, Gonzalo Perez, Wappner, Diego, Esteban, Ignacio, Polack, Fernando, Sullivan, David J, Internal Medicine, Surgery, and Medical Microbiology & Infectious Diseases

Subjects
Microbiology (medical), Infectious Diseases
Abstract

Background Outpatient monoclonal antibodies are no longer effective and antiviral treatments for coronavirus disease 2019 (COVID-19) disease remain largely unavailable in many countries worldwide. Although treatment with COVID-19 convalescent plasma (CCP) is promising, clinical trials among outpatients have shown mixed results. Methods We conducted an individual participant data meta-analysis from outpatient trials to assess the overall risk reduction for all-cause hospitalizations by day 28 in transfused participants. Relevant trials were identified by searching Medline, Embase, medRxiv, World Health Organization COVID-19 Research Database, Cochrane Library, and Web of Science from January 2020 to September 2022. Results Five included studies from 4 countries enrolled and transfused 2620 adult patients. Comorbidities were present in 1795 (69%). The virus neutralizing antibody dilutional titer levels ranged from 8 to 14 580 in diverse assays. One hundred sixty of 1315 (12.2%) control patients were hospitalized, versus 111 of 1305 (8.5%) CCP-treated patients, yielding a 3.7% (95% confidence interval [CI], 1.3%–6.0%; P = .001) absolute risk reduction and 30.1% relative risk reduction for all-cause hospitalization. The hospitalization reduction was greatest in those with both early transfusion and high titer with a 7.6% absolute risk reduction (95% CI, 4.0%–11.1%; P = .0001) accompanied by at 51.4% relative risk reduction. No significant reduction in hospitalization was seen with treatment >5 days after symptom onset or in those receiving CCP with antibody titers below the median titer. Conclusions Among outpatients with COVID-19, treatment with CCP reduced the rate of all-cause hospitalization and may be most effective when given within 5 days of symptom onset and when antibody titer is higher.

Published
2023

34. Levels of fibrinogen variants are altered in severe COVID-19

Author

de Vries, Judith J., additional, Visser, Chantal, additional, van Ommen, Maureen, additional, Rokx, Casper, additional, van Nood, Els, additional, van Gorp, Eric C.M., additional, Goeijenbier, Marco, additional, van den Akker, Johannes P.C., additional, Endeman, Henrik, additional, Rijken, Dingeman C., additional, Kruip, Marieke J.H.A., additional, Weggeman, Miranda, additional, Koopman, Jaap, additional, and de Maat, Moniek, additional

Published
2023
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35. Exploring the Breastfeeding Desires and Decision-Making of Women Living with HIV in the Netherlands: Implications for Perinatal HIV Management in Developed Countries

Author

Bukkems, Vera E., primary, Finkenflügel, Renee N.N., additional, Grintjes, Karin, additional, Marneef, Manon, additional, de Haan, Martine, additional, Mielitz, Inga, additional, van Hulzen, Astrid, additional, Rokx, Casper, additional, van Leeuwen, Elisabeth, additional, Nellen, Jeannine F., additional, Burger, David M., additional, and Colbers, Angela, additional

Published
2023
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37. Clinical decision support systems to guide healthcare providers on HIV testing

Author

Smit, Mikaela, Jordans, Carlijn C E, Reinhard, Jitte M, Bramer, Wichor M, Verbon, Annelies, Rokx, Casper, Calmy, Alexandra, Internal Medicine, and Medical Microbiology & Infectious Diseases

Subjects
Infectious Diseases, SDG 3 - Good Health and Well-being, Immunology, Immunology and Allergy
Abstract

OBJECTIVE: To understand the impact of clinical decision support systems (CDSSs) on improving HIV testing and diagnosis.DESIGN: An original global systematic review (PROSPERO Number: CRD42020175576) of peer-reviewed articles reporting on electronic CDSSs that generate triggers encouraging healthcare providers to perform an HIV test.METHODS: Medline, Embase, Cochrane CENTRAL and CINAHL EBSCOhost were searched up to 17 November 2020 and reference lists of included articles were checked. Qualitative and quantitative syntheses (using meta-analyses) of identified studies were performed.RESULTS: The search identified 1424 records. Twenty-two articles met inclusion criteria (19 of 22 non-HIV endemic settings); 18 clinical and four laboratory-driven reminders. Reminders promoted 'universal' HIV testing for all patients without a known HIV infection and no recent documented HIV test, or 'targeted' HIV testing in patients with clinical risk-factors or specific diagnostic tests. CDSSs increased HIV testing in hospital and nonhospital setting, with the pooled risk-ratio amongst studies reporting comparable outcome measures in hospital settings (n = 3) of 2.57 [95% confidence interval (CI) 1.53-4.33, random-effect model] and in nonhospital settings (n = 4) of 2.13 (95% CI 1.78-4.14, random effect model). Results of the clinical impact of CDSSs on HIV diagnosis were mixed.CONCLUSION: CDSSs improve HIV testing and may, potentially, improve diagnosis. The data support the broader study of CDSSs in low- and high prevalent HIV settings to determine their precise impact on UNAIDS goals to reach universal HIV testing and treatment coverage.

Published
2022

38. The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Author

Prins, Henrieke A. B., primary, Crespo, Raquel, additional, Lungu, Cynthia, additional, Rao, Shringar, additional, Li, Letao, additional, Overmars, Ronald J., additional, Papageorgiou, Grigorius, additional, Mueller, Yvonne M., additional, Stoszko, Mateusz, additional, Hossain, Tanvir, additional, Kan, Tsung Wai, additional, Rijnders, Bart J. A., additional, Bax, Hannelore I., additional, van Gorp, Eric C. M., additional, Nouwen, Jan L., additional, de Vries-Sluijs, Theodora E. M. S., additional, Schurink, Carolina A. M., additional, de Mendonça Melo, Mariana, additional, van Nood, Els, additional, Colbers, Angela, additional, Burger, David, additional, Palstra, Robert-Jan, additional, van Kampen, Jeroen J. A., additional, van de Vijver, David A. M. C., additional, Mesplède, Thibault, additional, Katsikis, Peter D., additional, Gruters, Rob A., additional, Koch, Birgit C. P., additional, Verbon, Annelies, additional, Mahmoudi, Tokameh, additional, and Rokx, Casper, additional

Published
2023
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41. HIV transmission among acutely infected participants of a Dutch cohort study 2015-2021 is not associated with large, clustered outbreaks

Author

Prins, Henrieke A. B., Rokx, Casper, Verbon, Annelies, van Sighem, Ard, de Bree, Godelieve J., Dijkstra, Maartje, Prins, Jan M., Reiss, Peter, van Kampen, Jeroen J. A., van de Vijver, David A. M. C., Internal Medicine, Medical Microbiology & Infectious Diseases, Virology, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, APH - Global Health, General Internal Medicine, and Global Health

Subjects
acute HIV infection, Infectious Diseases, early HIV infection, SDG 3 - Good Health and Well-being, Immunology, transmission, HIV, Immunology and Allergy, cohort, phylogeny
Abstract

OBJECTIVE: Timely identification of acute or early HIV infection (AEHI) is important to help prevent onward transmission, and understanding the number of secondary infections resulting from individuals with AEHI is key to planning HIV prevention services and case finding. DESIGN: We performed a phylogenetic investigation of a dense sample of individuals with AEHI who took part in the Netherlands Cohort Study on Acute HIV infection (NOVA) in the Netherlands during 2015-2021. METHODS: Transmission clusters were identified using phylogenetic analyses based on HIV pol sequences. The Tamura-Nei model was used to estimate genetic distance. A number of 1000 bootstraps was used to check the reliability of clustering using maximum likelihood. A cluster was defined as having a bootstrap value of at least 95% and a genetic distance of at most 1.5%. Sensitivity analyses using different values for the bootstrap and genetic distance were performed to study the reproducibility of the clustering. RESULTS: Of the 156 participants included in NOVA between July 2015 and April 2021, 134 individuals for whom baseline characteristics and genotypic resistance data at baseline were available could be included. We identified 10 clusters, but the majority of persons (111/134) were not part of a cluster, suggesting mainly independent transmission events. CONCLUSION: Mainly independent transmission events among a study population consisting predominantly of MSM in a low-incidence high-resource setting is likely the result of active AEHI case finding and direct start of treatment, and the roll-out over recent years of preventive measures such as preexposure prophylaxis.

Published
2023

42. Erratum: Correction: Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study (PLoS medicine (2022) 19 10 (e1003979))

Author

Hensley, Kathryn S., Jongkees, Marlou J., Geers, Daryl, GeurtsvanKessel, Corine H., Mueller, Yvonne M., Dalm, Virgil A. S. H., Papageorgiou, Grigorios, Steggink, Hanka, Gorska, Alicja, Bogers, Susanne, den Hollander, Jan G., Bierman, Wouter F. W., Gelinck, Luc B. S., Schippers, Emile F., Ammerlaan, Heidi S. M., van der Valk, Marc, van Vonderen, Marit G. A., Delsing, Corine E., Gisolf, Elisabeth H., Bruns, Anke H. W., Lauw, Fanny N., Berrevoets, Marvin A. H., Sigaloff, Kim C. E., Soetekouw, Robert, Branger, Judith, de Mast, Quirijn, Lammers, Adriana J. J., Lowe, Selwyn H., de Vries, Rory D., Katsikis, Peter D., Rijnders, Bart J. A., Brinkman, Kees, Roukens, Anna H. E., Rokx, Casper, Infectious diseases, and AII - Infectious diseases

Abstract

[This corrects the article DOI: 10.1371/journal.pmed.1003979.].

Published
2023

43. Erratum:Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study (PLoS Med (2022) 19:10 (e1003979) DOI: 10.1371/journal.pmed.1003979)

Author

Hensley, Kathryn S., Jongkees, Marlou J., Geers, Daryl, GeurtsvanKessel, Corine H., Mueller, Yvonne M., Dalm, Virgil A. S. H., Papageorgiou, Grigorios, Steggink, Hanka, Gorska, Alicja, Bogers, Susanne, den Hollander, Jan G., Bierman, Wouter F. W., Gelinck, Luc B. S., Schippers, Emile F., Ammerlaan, Heidi S. M., van der Valk, Marc, van Vonderen, Marit G. A., Delsing, Corine E., Gisolf, Elisabeth H., Bruns, Anke H. W., Lauw, Fanny N., Berrevoets, Marvin A. H., Sigaloff, Kim C. E., Soetekouw, Robert, Branger, Judith, de Mast, Quirijn, Lammers, Adriana J. J., Lowe, Selwyn H., de Vries, Rory D., Katsikis, Peter D., Rijnders, Bart J. A., Brinkman, Kees, Roukens, Anna H. E., Rokx, Casper, and Internal medicine

Abstract

Fig 3 panel B contains a mislabeled axis. The label ‘Pre—HIV negative’ should be ‘Post—HIV negative.’ Please see the correct Fig 3 below.

Published
2023

44. The 2000HIV study: Design, multi-omics methods and participant characteristics

Author

Vos, Wilhelm A. J. W., primary, Groenendijk, Albert L., additional, Blaauw, Marc J. T., additional, van Eekeren, Louise E., additional, Navas, Adriana, additional, Cleophas, Maartje C. P., additional, Vadaq, Nadira, additional, Matzaraki, Vasiliki, additional, dos Santos, Jéssica C., additional, Meeder, Elise M. G., additional, Fröberg, Janeri, additional, Weijers, Gert, additional, Zhang, Yue, additional, Fu, Jingyuan, additional, ter Horst, Rob, additional, Bock, Christoph, additional, Knoll, Rainer, additional, Aschenbrenner, Anna C., additional, Schultze, Joachim, additional, Vanderkerckhove, Linos, additional, Hwandih, Talent, additional, Wonderlich, Elizabeth R., additional, Vemula, Sai V., additional, van der Kolk, Mike, additional, de Vet, Sterre C. P., additional, Blok, Willem L., additional, Brinkman, Kees, additional, Rokx, Casper, additional, Schellekens, Arnt F. A., additional, de Mast, Quirijn, additional, Joosten, Leo A. B., additional, Berrevoets, Marvin A. H., additional, Stalenhoef, Janneke E., additional, Verbon, Annelies, additional, van Lunzen, Jan, additional, Netea, Mihai G., additional, and van der Ven, Andre J. A. M., additional

Published
2022
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45. COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials

Author

Levine, Adam C., primary, Fukuta, Yuriko, additional, Huaman, Moises A., additional, Ou, Jiangda, additional, Meisenberg, Barry R., additional, Patel, Bela, additional, Paxton, James H., additional, Hanley, Daniel F., additional, Rijnders, Bart JA, additional, Gharbharan, Arvind, additional, Rokx, Casper, additional, Zwaginga, Jaap Jan, additional, Alemany, Andrea, additional, Mitjà, Oriol, additional, Ouchi, Dan, additional, Millat-Martinez, Pere, additional, Durkalski-Mauldin, Valerie, additional, Korley, Frederick K., additional, Dumont, Larry J., additional, Callaway, Clifton W., additional, Libster, Romina, additional, Marc, Gonzalo Perez, additional, Wappner, Diego, additional, Esteban, Ignacio, additional, Polack, Fernando, additional, and Sullivan, David J., additional

Published
2022
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46. Immunogenicity of an Additional mRNA-1273 SARS-CoV-2 Vaccination in People With HIV With Hyporesponse After Primary Vaccination

Author

Jongkees, Marlou J, primary, Geers, Daryl, additional, Hensley, Kathryn S, additional, Huisman, Wesley, additional, GeurtsvanKessel, Corine H, additional, Bogers, Susanne, additional, Gommers, Lennert, additional, Papageorgiou, Grigorios, additional, Jochems, Simon P, additional, den Hollander, Jan G, additional, Schippers, Emile F, additional, Ammerlaan, Heidi S M, additional, Bierman, Wouter F W, additional, van der Valk, Marc, additional, Berrevoets, Marvin A H, additional, Soetekouw, Robert, additional, Langebeek, Nienke, additional, Bruns, Anke H W, additional, Leyten, Eliane M S, additional, Sigaloff, Kim C E, additional, van Vonderen, Marit G A, additional, Delsing, Corine E, additional, Branger, Judith, additional, Katsikis, Peter D, additional, Mueller, Yvonne M, additional, de Vries, Rory D, additional, Rijnders, Bart J A, additional, Brinkman, Kees, additional, Rokx, Casper, additional, and Roukens, Anna H E, additional

Published
2022
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47. HIV transmission among acutely infected participants of a Dutch cohort study 2015–2021 is not associated with large, clustered outbreaks

Author

Prins, Henrieke A.B., primary, Rokx, Casper, additional, Verbon, Annelies, additional, van Sighem, Ard, additional, de Bree, Godelieve J., additional, Dijkstra, Maartje, additional, Prins, Jan M., additional, Reiss, Peter, additional, van Kampen, Jeroen J.A., additional, and van de Vijver, David A.M.C., additional

Published
2022
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49. National medical specialty guidelines of HIV indicator conditions in Europe lack adequate HIV testing recommendations: a systematic guideline review

Author

Jordans, Carlijn C.E., Vasylyev, Marta, Rae, Caroline, Jakobsen, Marie Louise, Vassilenko, Anna, Dauby, Nicolas, Grevsen, Anne Louise, Jakobsen, Stine Finne, Raahauge, Anne, Champenois, Karen, Papot, Emmanuelle, Malin, Jakob J., Boender, T. Sonia, Behrens, Georg M.N., Gruell, Henning, Neumann, Anja, Spinner, Christoph D., Valbert, Frederik, Akinosoglou, Karolina, Kostaki, Evangelia G., Nozza, Silvia, Giacomelli, Andrea, Lapadula, Giuseppe, Mazzitelli, Maria, Torti, Carlo, Matulionyte, Raimonda, Matulyte, Elzbieta, Van Welzen, Berend J., Hensley, Kathryn S., Thompson, Magdalena, Ankiersztejn-Bartczak, Magdalena, Skrzat-Klapaczyńska, Agata, Sǎndulescu, Oana, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Miron, Viktor Daniel, Pokrovskaya, Anastasia, Hachfeld, Anna, Dorokhina, Antonina, Sukach, Maryna, Lord, Emily, Sullivan, Ann K., Rokx, Casper, Medical Microbiology & Infectious Diseases, Jordans, C, Vasylyev, M, Rae, C, Jakobsen, M, Vassilenko, A, Dauby, N, Grevsen, A, Jakobsen, S, Raahauge, A, Champenois, K, Papot, E, Malin, J, Boender, T, Behrens, G, Gruell, H, Neumann, A, Spinner, C, Valbert, F, Akinosoglou, K, Kostaki, E, Nozza, S, Giacomelli, A, Lapadula, G, Mazzitelli, M, Torti, C, Matulionyte, R, Matulyte, E, Van Welzen, B, Hensley, K, Thompson, M, Ankiersztejn-Bartczak, M, Skrzat-Klapaczyńska, A, Săndulescu, O, Streinu-Cercel, A, Miron, V, Pokrovskaya, A, Hachfeld, A, Dorokhina, A, Sukach, M, Lord, E, Sullivan, A, and Rokx, C

Subjects
Europe, SDG 3 - Good Health and Well-being, Epidemiology, HIV, indicator conditions, AIDS-defining condition, Virology, Public Health, Environmental and Occupational Health, Medizin, guidelines, Wirtschaftswissenschaften, 610 Medizin und Gesundheit
Abstract

Background Adequate identification and testing of people at risk for HIV is fundamental for the HIV care continuum. A key strategy to improve timely testing is HIV indicator condition (IC) guided testing. Aim To evaluate the uptake of HIV testing recommendations in HIV IC-specific guidelines in European countries. Methods Between 2019 and 2021, European HIV experts reviewed guideline databases to identify all national guidelines of 62 HIV ICs. The proportion of HIV IC guidelines recommending HIV testing was reported, stratified by subgroup (HIV IC, country, eastern/western Europe, achievement of 90–90–90 goals and medical specialty). Results Of 30 invited European countries, 15 participated. A total of 791 HIV IC guidelines were identified: median 47 (IQR: 38–68) per country. Association with HIV was reported in 69% (545/791) of the guidelines, and 46% (366/791) recommended HIV testing, while 42% (101/242) of the AIDS-defining conditions recommended HIV testing. HIV testing recommendations were observed more frequently in guidelines in eastern (53%) than western (42%) European countries and in countries yet to achieve the 90–90–90 goals (52%) compared to those that had (38%). The medical specialties internal medicine, neurology/neurosurgery, ophthalmology, pulmonology and gynaecology/obstetrics had an HIV testing recommendation uptake below the 46% average. None of the 62 HIV ICs, countries or medical specialties had 100% accurate testing recommendation coverage in all their available HIV IC guidelines. Conclusion Fewer than half the HIV IC guidelines recommended HIV testing. This signals an insufficient adoption of this recommendation in non-HIV specialty guidelines across Europe.

Published
2022

50. A multinational Delphi consensus to end the COVID-19 public health threat

Author

Lazarus, Jeffrey V., Romero, Diana, Kopka, Christopher J., Karim, Salim Abdool, Abu-Raddad, Laith J., Almeida, Gisele, Baptista-Leite, Ricardo, Barocas, Joshua A., Barreto, Mauricio L., Bar-Yam, Yaneer, Bassat, Quique, Batista, Carolina, Bazilian, Morgan, Chiou, Shu-Ti, del Rio, Carlos, Dore, Gregory J., Gao, George F., Gostin, Lawrence O., Hellard, Margaret, Jimenez, Jose L., Kang, Gagandeep, Lee, Nancy, Matičič, Mojca, McKee, Martin, Nsanzimana, Sabin, Oliu-Barton, Miquel, Pradelski, Bary, Pyzik, Oksana, Rabin, Kenneth, Raina, Sunil, Rashid, Sabina Faiz, Rathe, Magdalena, Saenz, Rocio, Singh, Sudhvir, Trock-Hempler, Malene, Villapol, Sonia, Yap, Peiling, Binagwaho, Agnes, Kamarulzaman, Adeeba, El-Mohandes, Ayman, Barreto, Mauricio, Abdulla, Salim, Addleman, Sarah, Aghayeva, Gulnara, Agius, Raymond, Ahmed, Mohammed, Ramy, Mohamed Ahmed, Aide, Pedro, Aleman, Soo, Alfred, Jean-Patrick, Ali, Shamim, Aliaga, Jorge, Aloudat, Tammam, Alqahtani, Saleh A., Al-Salman, Jameela, Amuasi, John H., Agrawal, Anurag, Anwar, Wagida, Araujo-Jorge, Tania, Artaza, Osvaldo, Asadi, Leyla, Awuku, Yaw, Baker, Michael, Barberia, Lorena, Bascolo, Ernesto, Belcher, Paul, Bell, Lizett, Benzaken, Adele, Bergholtz, Emil, Bhadelia, Nahid, Bhan, Anant, Bilodeau, Stephane, Bitrán, Ricardo, Bluyssen, Philomena, Bosman, Arnold, Bozza, Fernando A., Brinkmann, Melanie M., Brown, Andrew, Mellado, Bruce, Bukusi, Elizabeth, Bullen, Chris, Buonanno, Giorgio, Burgess, Rochelle, Butler, Matthew, Byakika-Kibwika, Pauline, Cabieses, Baltica, Carlsson, Gunilla, Cascini, Fidelia, Chabala, Chishala, Chakroun, Mohamed, Cheng, null, Chetty, Agnes, Chumachenko, Dmytro, Consalves, Gregg, Conway Morris, Andrew, Cordie, Ahmed, Corrah, Tumani, Crabtree-Ramírez, Brenda, Dashdorj, Naranjargal, Davidovitch, Nadav, de Souza, Luis Eugenio, Dhariwal, Akshay Chand, Druică, Elena, Ergonul, Onder, Erondu, Ngozi A., Essar, Mohammad Yasir, Ewing, Andrew, Fanjul, Gonzalo, Feierstein, Daniel, Feigl-Ding, Eric, Figueroa, Ramon, Figueroa, John Peter, Fisher, Dale, Flores, Walter, Forero-Peña, David A., Frumkin, Howard, Gamkrelidze, Amiran, Gandhi, Monica, Garcia, Patricia, Garcia-Basteiro, Alberto L., García-Sastre, Adolfo, Garg, Suneela, Gbeasor-Komlanvi, null, Gershenson, Carlos, Gilada, Ishwar, Giovanella, Ligia, González, Marino, Green, Manfred S., Greenhalgh, Trisha, Griffin, Paul, Griffin, Stephen, Grinsztejn, Beatriz, Anand, Tanu, Guerra, Germán, Guinto, Renzo, Gujski, Mariusz, Guner, Rahmet, Hamdy, Adam, Hâncean, Marian-Gabriel, Haniffa, Abusayeed, Hartigan-Go, Kenneth Y., Hassan, Hoda K., Hay, Simon I., Heino, Matti T. J., Hel, Zdenek, Hotez, Peter, Hu, Jia, Hukić, Mirsada, IJsselmuiden, Carel, Iroko, Davidson, Iskarous, Maged, Izugbara, Chimaraoke, Jacobs, Choolwe, Jadad, Alejandro R., Jehan, Fyezah, Jordan, Ayana, Jroundi, Imane, Kain, Kevin, Kamberi, Fatjona, Karamov, Eduard, Karan, Abraar, Katz, Rebecca, Katzourakis, Aris, Kazembe, Abigail, Khamis, Faryal, Khamzayev, Komiljon, Khanyola, Judy, Khunti, Kamlesh, Kiguli-Malwadde, Elsie, Kim, Woo Joo, Kirenga, Bruce J., Klimovský, Daniel, Kmush, Brittany L., Knaul, Felicia, Kogevinas, Manolis, Kristensen, Frederik, Kumar, Dinesh, Kumar, Raman, Kvalsvig, Amanda, Lacerda, Marcus V., Lal, Arush, Lawton, Tom, Lemery, Jay, Leonardi, Anthony J., Li, Yuguo, Löttvall, Jan, Lounis, Mohamed, Maceira, Daniel, MacIntyre, C. Raina, Madani, Azzeddine, Magiorkinis, Gkikas, Malekzadeh, Reza, Choisy, Marc, Marcelin, Jasmine R., Marks, Guy B., Marr, Linsey, Marrazzo, Jeanne, Martina, Antonieta, Martín-Moreno, José M., Mateos, Carlos, Mayxay, Mayfong, Mazarati, Jean Bapiste, Mboup, Souleymane, McDonald, Jennifer, McMillan, Faye, Mechili, Enkeleint, Medici, Andre, Davis, Sarah L. M., Meier, Petra, Memish, Ziad A., Menon, Jaideep, Menon, Purnima, Mesiano-Crookston, Jonathan, Michie, Susan, Mikolasevic, Ivana, Milicevic, Ognjen, Mishra, Asit Kumar, Mohamed, Rahma, Mokdad, Ali H., Monroy-Valle, Michele, Morawska, Lidia, Moschos, Sterghios A., Motawea, Karam, Mousavi, Sayed Hamid, Mumtaz, Ghina, Munene, Peter K., Muñoz Almagro, Carmen, Muriuki, Janet, Muyingo, Sylvia, Naniche, Denise, Naylor, C. David, Ndembi, Nicaise, Nemec, Juraj, Nesteruk, Igor, Ngaruiya, Christine, Nguyen, Hung, Nikolova, Dafina, Nitzan, Dorit, Norheim, Ole, Noushad, Mohammed, Ntoumi, Francine, Nyborg, Gunhild Alvik, Ochodo, Eleanor, Odabasi, Zekaver, Okwen, Mbah Patrick, Olivia, Keiser, Ong, David S. Y., Opara, Ijeoma, Orozco, Miguel, Oshitani, Hitoshi, Pagel, Christina, Pai, Madhukar, Pálsdóttir, Björg, Papatheodoridis, Georgios, Paraskevis, Dimitrios, Leigh, Jeanna Parsons, Pécoul, Bernard, Peichl, Andreas, Perez-Then, Eddy, Duc, Phuc Pham, Philippe, Cécile, Pineda Rojas, Andrea, Pladsen, Courtney, Pozniak, Anton, Quiroga, Rodrigo, Qureshi, Huma, Rampal, Sanjay, Ranney, Megan, Rathe, Laura, Ratzan, Scott, Raventos, Henriette, Rees, Helen, Reis, Renata, Ricciardi, Walter, Rizk, Nesrine, Robalo, Magda, Robertson, Eleanor, Robinson, Leanne, Rokx, Casper, Ros, Tamsin, Røttingen, John-Arne, Rubin, Meir, Ruxrungtam, Kiat, Sadirova, Shakhlo, Saha, Senjuti, Salgado, Nelly, Sanchez, Lizet, Sangaramoorthy, Thurka, Santamaria-Ulloa, Carolina, Santos, Renata, Sawaf, Bisher, Schneider, Matthias F., Schooley, Robert T., Sener, Alper, Sepulveda, Jaime, Shah, Jaffer, Shibani, Mosa, Shoib, Sheikh, Sikazwe, Izukanji, Šimaitis, Aistis, Gill, Amandeep Singh, Skhvitaridze, Natia, Sokolović, Milka, Solomon, Roma, Solórzano, Xavier, Springer, Sandra A., Šrol, Jakub, Staines, Anthony, Stelfox, Henry T., Strathdee, Steffanie, Sulaiman, Lokman Hakim, Sutton, Brett, Svanæs, Dag, Swed, Sarya, Sypsa, Vana, Sørensen, Kristine, Tajudeen, Raji, Tan, Amy, Tang, Julian, Tanner, Marcel, Sethi, Tavpritesh, Temmerman, Marleen, Than, Kyu Kyu, Tinto, Halidou, Tomètissi, Sênoudé Pacôme, Torres, Irene, Tshering, null, Tsiodras, Sotirios, Tsofa, Benjamin, Vahlne, Anders, Vargas, Juan Rafael, Bernal, Ivan Dario Velez, Ventura, Deisy, Vilasanjuan, Rafael, Vipond, Joe, Wamala-Andersson, Sarah, Wargocki, Pawel, West, Robert, Weyand, Angela, White, Trenton M., Wolff, Guntram, Yao, Maosheng, Yates, Christian A., Yeboah, Georgina, Yee-Sin, Leo, Yi, Siyan, Teo, Yik-Ying, Yong, Poovorawan, Zamora-Mesía, Victor, Øvrehus, Anne, 0000-0001-9618-2299, 0000-0002-4832-9564, 0000-0002-4986-2133, 0000-0003-0790-0506, 0000-0003-0875-7596, 0000-0002-6994-1891, 0000-0002-3869-615X, 0000-0001-5286-4044, 0000-0001-6203-1847, 0000-0002-0121-9683, 0000-0003-1793-6350, 0000-0003-2418-0037, 0000-0002-5095-748X, 0000-0003-4492-3256, 0000-0002-5964-8210, 0000-0002-6779-3151, 0000-0002-8074-4450, Lazarus, Jeffrey V [0000-0001-9618-2299], Romero, Diana [0000-0002-4832-9564], Karim, Salim Abdool [0000-0002-4986-2133], Abu-Raddad, Laith J [0000-0003-0790-0506], Bassat, Quique [0000-0003-0875-7596], Chiou, Shu-Ti [0000-0002-6994-1891], Gao, George F [0000-0002-3869-615X], Gostin, Lawrence O [0000-0001-5286-4044], Jimenez, Jose L [0000-0001-6203-1847], McKee, Martin [0000-0002-0121-9683], Oliu-Barton, Miquel [0000-0003-1793-6350], Pradelski, Bary [0000-0003-2418-0037], Rathe, Magdalena [0000-0002-5095-748X], Trock-Hempler, Malene [0000-0003-4492-3256], Yap, Peiling [0000-0002-5964-8210], Binagwaho, Agnes [0000-0002-6779-3151], Kamarulzaman, Adeeba [0000-0002-8074-4450], Apollo - University of Cambridge Repository, Helsinki Collegium for Advanced Studies, Research Group of Nelli Hankonen, Doctoral Programme in Social Sciences, Academic Disciplines of the Faculty of Social Sciences, RS: CAPHRI - R2 - Creating Value-Based Health Care, International Health, Performance analysis and optimization of LARge Infrastructures and Systems (POLARIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Internal Medicine, Medical Microbiology & Infectious Diseases, Veritati - Repositório Institucional da Universidade Católica Portuguesa, and Lazarus J. V., Romero D., Kopka C. J., Karim S. A., Abu-Raddad L. J., Almeida G., Baptista-Leite R., Barocas J. A., Barreto M. L., Bar-Yam Y., et al.

Subjects
Pandemics/economics, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, COVID-19 Vaccines, Delphi Technique, General Science & Technology, International Cooperation, Temel Bilimler (SCI), ÇOK DİSİPLİNLİ BİLİMLER, Public Health/economics, [SHS]Humanities and Social Sciences, SDG 3 - Good Health and Well-being, RA0421 Public health. Hygiene. Preventive Medicine, Medicine and Health Sciences, Humans, prevention and control, human, Settore MED/42 - IGIENE GENERALE E APPLICATA, Health Education, Pandemics, Multidisipliner, Organizations, Multidisciplinary, MULTIDISCIPLINARY SCIENCES, COVID-19/economics, Temel Bilimler, pandemic, Communication, Health Policy, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Doğa Bilimleri Genel, COVID-19, 3142 Public health care science, environmental and occupational health, Delphi study, NATURAL SCIENCES, GENERAL, N/A, Public Opinion, Government, Natural Sciences (SCI), Public Health, Natural Sciences
Abstract

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches , while maintaining proven prevention measures using a vaccines-plus approach that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Published
2022

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