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2. Postoperative Respiratory Complications in SARS-CoV-2 Positive Pediatric Patients Across 20 United States Hospitals: A Cohort Study

Author

Reiter, Audra J, Ingram, Martha-Conley E, Raval, Mehul V, Garcia, Elisa, Hill, Madelyn, Aranda, Arturo, Chandler, Nicole M, Gonzalez, Raquel, Born, Kristen, Mack, Shale, Lamoshi, Abdulraouf, Lipskar, Aaron M, Han, Xiao-Yue, Fialkowski, Elizabeth, Spencer, Brianna, Kulaylat, Afif N, Barde, Amrene, Shah, Ami N, Adoumie, Maeva, Gross, Erica, Mehl, Steven C, Lopez, Monica E, Polcz, Valerie, Mustafa, Moiz M, Gander, Jeffrey W, Sullivan, Travis M, Sulkowski, Jason P, Ghani, Owais, Huang, Eunice Y, Rothstein, David, Muenks, E Peter, St Peter, Shawn D, Fisher, Jason C, Levy-Lambert, Dina, Reichl, Allison, Ignacio, Romeo C, Slater, Bethany J, Tsao, KuoJen, and Berman, Loren

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Pneumonia, Clinical Research, Pediatric, Infectious Diseases, Pneumonia & Influenza, Patient Safety, Respiratory, Good Health and Well Being, Humans, Male, Child, United States, Female, COVID-19, SARS-CoV-2, Cohort Studies, Retrospective Studies, Hospitals, Postoperative Complications, Pediatric surgery, Respiratory complications, Paediatrics and Reproductive Medicine, Pediatrics, Clinical sciences, Paediatrics
Abstract

IntroductionData examining rates of postoperative complications among SARS-CoV-2 positive children are limited. The purpose of this study was to evaluate the impact of symptomatic and asymptomatic SARS-CoV-2 positive status on postoperative respiratory outcomes for children.MethodsThis retrospective cohort study included SARS-CoV-2 positive pediatric patients across 20 hospitals who underwent general anesthesia from March to October 2020. The primary outcome was frequency of postoperative respiratory complications, including: high-flow nasal cannula/non invasive ventilation, reintubation, pneumonia, Extracorporeal Membrane Oxygenation (ECMO), and 30-day respiratory-related readmissions or emergency department (ED) visits. Univariate analyses were used to evaluate associations between patient and procedure characteristics and stratified analyses by symptoms were performed examining incidence of complications.ResultsOf 266 SARS-CoV-2 positive patients, 163 (61.7%) were male, and the median age was 10 years (interquartile range 4-14). The majority of procedures were emergent or urgent (n = 214, 80.5%). The most common procedures were appendectomies (n = 78, 29.3%) and fracture repairs (n = 40,15.0%). 13 patients (4.9%) had preoperative symptoms including cough or dyspnea. 26 patients (9.8%) had postoperative respiratory complications, including 15 requiring high-flow oxygen, 8 with pneumonia, 4 requiring non invasive ventilation, 3 respiratory ED visits, and 2 respiratory readmissions. Respiratory complications were more common among symptomatic patients than asymptomatic patients (30.8% vs. 8.7%, p = 0.01). Higher ASA class and comorbidities were also associated with postoperative respiratory complications.ConclusionsPostoperative respiratory complications are less common in asymptomatic versus symptomatic SARS-COV-2 positive children. Relaxation of COVID-19-related restrictions for time-sensitive, non urgent procedures in selected asymptomatic patients may be reasonably considered. Additionally, further research is needed to evaluate the costs and benefits of routine testing for asymptomatic patients.Level of evidenceIii, Respiratory complications.

Published
2023

5. Estimates of Treatable Deaths Within the First 20 Years of Life from Scaling Up Surgical Care at First-Level Hospitals in Low- and Middle-Income Countries.

Author

Sykes, Alicia G, Seyi-Olajide, Justina, Ameh, Emmanuel A, Ozgediz, Doruk, Abbas, Alizeh, Abib, Simone, Ademuyiwa, Adesoji, Ali, Abdelbasit, Aziz, Tasmiah Tahera, Chowdhury, Tanvir Kabir, Abdelhafeez, Hafeez, Ignacio, Romeo C, Keller, Benjamin, Klazura, Greg, Kling, Karen, Martin, Benjamin, Philipo, Godfrey Sama, Thangarajah, Hariharan, Yap, Ava, Meara, John G, Bundy, Donald AP, Jamison, Dean T, Mock, Charles N, Bickler, Stephen W, and On behalf of the Global Initiative for Children’s Surgery

Subjects
On behalf of the Global Initiative for Children’s Surgery, Humans, Developing Countries, Adolescent, Child, Child, Preschool, Infant, Newborn, Income, Hospitals, Global Health, Physical Injury - Accidents and Adverse Effects, Pediatric, Patient Safety, Clinical Research, Health Services, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Health and social care services research, 8.1 Organisation and delivery of services, Good Health and Well Being, Clinical Sciences, Surgery
Abstract

BackgroundSurgical care is an important, yet often neglected component of child health in low- and middle-income countries (LMICs). This study examines the potential impact of scaling up surgical care at first-level hospitals in LMICs within the first 20 years of life.MethodsEpidemiological data from the global burden of disease 2019 Study and a counterfactual method developed for the disease control priorities; 3rd Edition were used to estimate the number of treatable deaths in the under 20 year age group if surgical care could be scaled up at first-level hospitals. Our model included three digestive diseases, four maternal and neonatal conditions, and seven common traumatic injuries.ResultsAn estimated 314,609 (95% UI, 239,619-402,005) deaths per year in the under 20 year age group could be averted if surgical care were scaled up at first-level hospitals in LMICs. Most of the treatable deaths are in the under-5 year age group (80.9%) and relates to improved obstetrical care and its effect on reducing neonatal encephalopathy due to birth asphyxia and trauma. Injuries are the leading cause of treatable deaths after age 5 years. Sixty-one percent of the treatable deaths occur in lower middle-income countries. Overall, scaling up surgical care at first-level hospitals could avert 5·1% of the total deaths in children and adolescents under 20 years of age in LMICs per year.ConclusionsImproving the capacity of surgical services at first-level hospitals in LMICs has the potential to avert many deaths within the first 20 years of life.

Published
2022

6. Decision-Making in Pleural Drainage Following Lung Resection in Children: A Western Pediatric Surgery Research Consortium Survey

Author

Cairo, Sarah, Chao, Stephanie D., Fenton, Stephen J., Gollin, Gerald, Jensen, Aaron, Keane, Olivia A., Nicassio, Lauren, Ochoa, Brielle, Pandya, Samir, Patwardhan, Utsav M., Schnuck, Jamie K., Acker, Shannon N., Kelley-Quon, Lorraine I., Lee, Justin H., Shew, Stephen B., Fialkowski, Elizabeth, Ignacio, Romeo C., Melhado, Caroline, Qureshi, Faisal G., Russell, Katie W., and Rothstein, David H.

Published
2024
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7. Tumor or Inflammatory Myofibroblastic Reaction in an Adolescent With an Abdominal Lymphatic Malformation?

Author

Lee, Joseph J, Ignacio, Romeo C, Vicente, Diego A, Bachmann, Angela M, Choi, Pamela M, Ignacio, Romeo, Bachmann, Angela, and Choi, Pamela

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Digestive Diseases, reactive myofibroblastic proliferation, abdominal lymphatic malformation, retrogastric mass, abdominal mass, abdominal lymphangioma, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

We report the case of a 17-year-old male who presented with intractable nausea and vomiting. Cross-sectional imaging revealed a large retrogastric abdominal mass. Fine needle aspiration done via endoscopic ultrasound (EUS) was nondiagnostic. Exploratory laparotomy revealed a large inflammatory mass densely adherent to the stomach and retroperitoneum. Incisional biopsy frozen section revealed spindle cells, and subsequent resection of the mass with en-bloc subtotal gastrectomy with Roux-en-y gastrojejunostomy reconstruction was performed. Final pathology demonstrated a lymphatic malformation with reactive myofibroblastic proliferation. Inflammatory abdominal lymphatic malformations are especially rare and not well described in the literature. These masses may present diagnostic challenges until the specimen is sent for pathologic analysis.

Published
2022

8. Child physical abuse and COVID-19: Trends from nine pediatric trauma centers

Author

Russell, Katie W, Acker, Shannon N, Ignacio, Romeo C, Lofberg, Katrine M, Garvey, Erin M, Chao, Stephanie D, Bliss, David W, Smith, Caitlin A, Nehra, Deepika, Anderson, Melissa L, Bunnell, Brittney L, Shahi, Niti, Perry, John M, Evans, Lauren L, Kwong, Jacky Z, Tobias, Joseph, Rohan, Autumn, Pickett, Kaci L, Kaar, Jill L, Kastenberg, Zachary J, Laskey, Antoinette L, Scaife, Eric R, and Jensen, Aaron R

Subjects
Violence Research, Clinical Research, Child Abuse and Neglect Research, Physical Injury - Accidents and Adverse Effects, Patient Safety, Childhood Injury, Unintentional Childhood Injury, HIV/AIDS, Prevention, Pediatric, Injuries and accidents, Good Health and Well Being, Adult, COVID-19, Child, Child Abuse, Humans, Pandemics, Physical Abuse, Retrospective Studies, SARS-CoV-2, Trauma Centers, Child abuse, Nonaccidental trauma, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

BackgroundEconomic, social, and psychologic stressors are associated with an increased risk for abusive injuries in children. Prolonged physical proximity between adults and children under conditions of severe external stress, such as witnessed during the COVID-19 pandemic with "shelter-in-place orders", may be associated with additional increased risk for child physical abuse. We hypothesized that child physical abuse rates and associated severity of injury would increase during the early months of the pandemic as compared to the prior benchmark period.MethodsWe conducted a nine-center retrospective review of suspected child physical abuse admissions across the Western Pediatric Surgery Research Consortium. Cases were identified for the period of April 1-June 30, 2020 (COVID-19) and compared to the identical period in 2019. We collected patient demographics, injury characteristics, and outcome data.ResultsThere were no significant differences in child physical abuse cases between the time periods in the consortium as a whole or at individual hospitals. There were no differences between the study periods with regard to patient characteristics, injury types or severity, resource utilization, disposition, or mortality.ConclusionsApparent rates of new injuries related to child physical abuse did not increase early in the COVID-19 pandemic. While this may suggest that pediatric physical abuse was not impacted by pandemic restrictions and stresses, it is possible that under-reporting, under-detection, or delays in presentation of abusive injuries increased during the pandemic. Long-term follow-up of subsequent rates and severity of child abuse is needed to assess for unrecognized injuries that may have occurred.

Published
2022

12. Cervical Collar-Associated Pressure Injury in Pediatric Trauma Patients: A Western Pediatric Surgery Research Consortium Study

Author

Auguste, Kurtis, Beni, Catherine, Braga, Bruno P., Buckley, Robert T., Chu, Jason, Durand, Rachelle, Floan, Gretchen M., Gonda, David D., Iyer, Rajiv R., Jamshidi, Ramin, Koral, Korgun, Kruk, Peter G., Linnau, Ken, Jason Liu, Chia-Shang, McNevin, Kathryn, O'Neill, Brent, Pandya, Samir, Polukoff, Natalya E., Prendergast, Connor, Prolo, Laura M., Rampton, John, Regner, Michael, Ronecker, Jennifer, Sabapaty, Akanksha, Sayama, Christine, Selesner, Leigh, Smith, Karch M., Stence, Nick, Thiessen, Jaclyn, Tong, Elizabeth, Vaughn, Jennifer A., Melhado, Caroline, Russell, Katie W., Acker, Shannon N., Padilla, Benjamin E., Lofberg, Katrine, Spurrier, Ryan G., Robinson, Bryce, Chao, Stephanie, Ignacio, Romeo C., Ryan, Mark, and Jensen, Aaron R.

Published
2024
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15. Ovarian Tumors

Author

Sykes, Alicia G., Fallat, Mary E., Ignacio, Romeo C., Jr., Puri, Prem, editor, and Höllwarth, Michael E., editor

Published
2023
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17. “Surgery First” vs. “Endoscopy First” for Pediatric Choledocholithiasis Presenting at the End of the Week - A CARES Working Group Study

Author

Reid, Garrett, Rauh, Jessica L., Wood, Elizabeth, Dantes, Goeto, Santore, Matthew T., Wallace, Marshall W., Zamora, Irving J., Collings, Amelia, Callier, Kylie, Slater, Bethany J., Krinock, Derek, Siddiqui, Sabina, Vandewalle, Robert, Witte, Amanda, Flynn-O-Brien, Katherine, Patwardhan, Utsav M., Ignacio, Romeo C., Knod, Jennifer Leslie, Dukleska, Katerina, Livingston, Michael H., Scholz, Stefan, Bosley, Maggie, Neff, Lucas, and Alemayehu, Hanna

Published
2024
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21. Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease.

Author

Bickler, Stephen W, Cauvi, David M, Fisch, Kathleen M, Prieto, James M, Sykes, Alicia G, Thangarajah, Hariharan, Lazar, David A, Ignacio, Romeo C, Gerstmann, Dale R, Ryan, Allen F, Bickler, Philip E, and De Maio, Antonio

Subjects
Fibroblasts, Dermis, Humans, Peptidyl-Dipeptidase A, Receptors, Virus, Gene Expression Profiling, Age Factors, Gene Expression Regulation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Receptors, Pattern Recognition, Young Adult, RNA-Seq, COVID-19, SARS-CoV-2, Aging, Pattern recognition receptors, Skin fibroblasts, Toll-like receptor 4, Human Genome, Vaccine Related, Biodefense, Infectious Diseases, Lung, Clinical Research, Pneumonia, Prevention, Emerging Infectious Diseases, Genetics, Good Health and Well Being, Medical Biochemistry and Metabolomics, Oncology and Carcinogenesis, Genetics & Heredity
Abstract

BackgroundOlder aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes.MethodsUsing a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2.ResultsExtremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins.ConclusionsAssessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels.

Published
2021

22. Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections

Author

Jacobson, Jillian C., Ryan, Mark L., Vogel, Adam M., Mehl, Steven C., Acker, Shannon N., Prendergast, Connor, Padilla, Benjamin E., Lee, Justin, Chao, Stephanie D., Martin, Nolan R., Russell, Katie W., Larsen, Kezlyn, Harting, Matthew T., Linden, Allison F., Ignacio, Romeo C., Jr, Slater, Bethany J., Juang, David, Jensen, Aaron R., Melhado, Caroline G., Pelayo, Juan Carlos, Zhong, Allen, Spencer, Brianna L., Gadepalli, Samir K., Maamari, Mia, Jimenez Valencia, Maria, Qureshi, Faisal G., and Pandya, Samir R.

Published
2024
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26. Neck Injuries

Author

Penn, Edward B., Jr., Lake, Charissa M., Ignacio, Romeo C., Kennedy Jr, Alfred P., editor, Ignacio, Romeo C., editor, and Ricca, Robert, editor

Published
2022
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31. Identification and Evaluation of Non-Accidental Trauma in the Pediatric Population: A Clinical Review

Author

Sophia M. V. Schermerhorn, Oliver J. Muensterer, and Romeo C. Ignacio

Subjects
non-accidental trauma, child abuse, child physical abuse, non-accidental injury, skeletal survey, Pediatrics, RJ1-570
Abstract

Non-accidental trauma (NAT) is a major cause of morbidity and mortality for children around the world and most significantly impacts children under one year of age. Prompt and comprehensive treatment of these children relies on a high index of suspicion from any medical provider that treats pediatric patients. This review discusses those most at risk for experiencing NAT, and common initial presentations, to assist providers in the identification of potential victims. In addition, this review provides guidance on the recommended workup for these patients so that the full extent of associated injuries may be identified and the appropriate healthcare team may be assembled.

Published
2024
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32. Standardized perioperative care reduces colorectal surgical site infection in children: A Western Pediatric Surgery Research Consortium multicenter analysis

Author

Tobias, Joseph, Padilla, Benjamin E., Lee, Justin, Chen, Stephanie, Wang, Kasper S., Kelley-Quon, Lorraine I., Mueller, Claudia, Shew, Stephen B., Joskowitz, Katie, Ignacio, Romeo C., Jr., Evans, Lauren L., Jensen, Aaron R., Acker, Shannon N., Mason, Andrew, Johnson, Alicia, McConahey, Jessica, Hansen, Erik, Pandya, Samir R., Short, Scott S., Russell, Katie W., Nicassio, Lauren, Smith, Caitlin A., and Fialkowski, Elizabeth

Published
2023
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35. Understanding the burden of traumatic injuries at the United States–Mexico border: A scoping review of the literature

Author

Keller, Benjamin A., Skubic, Jeffrey, Betancourt-Garcia, Monica, Ignacio, Romeo C., Radowsky, Jason S., Tyroch, Alan H., Lascano, Carlos Palacio, Joseph, Bellal, Stewart, Collin, Moore, Forrest O., Costantini, Todd W., Rizzo, Julie A., Paul, Jasmeet S., Galindo, Roger M., Silva, Aaron, Coimbra, Raul, and Berndtson, Allison E.

Published
2023
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38. Adolescent Vaping-Associated Trauma in the Western United States

Author

Russell, Katie W., Katz, Micah G., Phillips, Ryan C., Kelley-Quon, Lorraine I., Acker, Shannon N., Shahi, Niti, Lee, Justin H., Fialkowski, Elizabeth A., Nacharaju, Deepthi, Smith, Caitlin A., Jensen, Aaron R., Mueller, Claudia M., Padilla, Benjamin E., Ignacio, Romeo C., Ourshalimian, Shadassa, Wang, Kasper S., Ostlie, Daniel J., Fenton, Stephen J., and Kastenberg, Zachary J.

Published
2022
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42. Attitudes Affecting Decision-Making for Use of Radiologic Enteral Contrast in the Management of Pediatric Adhesive Small Bowel Obstruction: A Survey Study of Pediatric Surgeons

Author

Acker, Shannon N., Diaz-Miron, Jose, Ignacio, Romeo C., Thangarajah, Hari, Russell, Katie W., Lofberg, Katrine, Shew, Stephen B., Peterson, Pamela N, Kelley-Quon, Lorraine I., Jensen, Aaron R., Lee, Justin, Padilla, Ben, Smith, Caitlin A., Kastenberg, Zachary J., Azarow, Kenneth S., Ostlie, Daniel J., Wang, Kasper S., and Inge, Thomas H.

Published
2021
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44. Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Author

Hall, Roger, Roos-Hesselink, Jolien, Stein, Joerg, Parsonage, William Anthony, Budts, Werner, De Backer, Julie, Grewal, Jasmin, Marelli, Ariane, Kaemmerer, Harald, Jondeau, Guillaume, Johnson, Mark, Maggioni, Aldo P., Tavazzi, Luigi, Thilen, Ulf, Elkayam, Uri, Otto, Catherine, Sliwa, Karen, Aquieri, A., Saad, A., Vega, H. Ruda, Hojman, J., Caparros, J.M., Blanco, M. Vazquez, Arstall, M., Chung, C.M., Mahadavan, G., Aldridge, E., Wittwer, M., Chow, Y.Y., Parsonage, W.A., Lust, K., Collins, N., Warner, G., Hatton, R., Gordon, A., Nyman, E., Stein, J., Donhauser, E., Gabriel, H., Bahshaliyev, A., Guliyev, F., Hasanova, I., Jahangirov, T., Gasimov, Z., Salim, A., Ahmed, C.M., Begum, F., Hoque, M.H., Mahmood, M., Islam, M.N., Haque, P.P., Banerjee, S.K., Parveen, T., Morissens, M., De Backer, J., Demulier, L., de Hosson, M., Budts, W., Beckx, M., Kozic, M., Lovric, M., Kovacevic-Preradovic, T., Chilingirova, N., Kratunkov, P., Wahab, N., McLean, S., Gordon, E., Walter, L., Marelli, A., Montesclaros, A.R., Monsalve, G., Rodriguez, C., Balthazar, F., Quintero, V., Palacio, W., Cadavid, L.A. Mejía, Ortiz, E. Munoz, Hoyos, F. Fortich, Guerrero, E. Arevalo, Ricardo, J. Gandara, Penagos, J. Velasquez, Vavera, Z., Prague, Popelova, J., Vejlstrup, N., Grønbeck, L., Johansen, M., Ersboll, A., Elrakshy, Y., Eltamawy, K., Abd-El Aziz, M. Gamal, El Nagar, A., Ebaid, H., Elenin, H. Abo, Saed, M., Farag, S., Makled, W., Sorour, K., Ashour, Z., El-Sayed, G., Meguid Mahdy, M. Abdel, Taha, N., Dardeer, A., Shabaan, M., Ali, M., Moceri, P., Duthoit, G., Gouton, M., Nizard, J., Baris, L., Cohen, S., Ladouceur, M., Khimoud, D., Iung, B., Berger, F., Olsson, A., Gembruch, U., Merz, W.M., Reinert, E., Clade, S., Kliesch, Y., Wald, C., Sinning, C., Kozlik-Feldmann, R., Blankenberg, S., Zengin-Sahm, E., Mueller, G., Hillebrand, M., Hauck, P., von Kodolitsch, Y., Zarniko, N., Baumgartner, Muenster H., Schmidt, R., Hellige, A., Tutarel, O., Kaemmerer, H., Kuschel, B., Nagdyman, N., Motz, R., Maisuradze, D., Frogoudaki, A., Iliodromitis, E., Anastasiou-Nana, M., Marousi, Triantafyllis, D., Bekiaris, G., Karvounis, H., Giannakoulas, G., Ntiloudi, D., Mouratoglou, S.A., Temesvari, A., Balint, H., Kohalmi, D., Merkely, B., Liptai, C., Nemes, A., Forster, T., Kalapos, A., Berek, K., Havasi, K., Ambrus, N., Shelke, A., Kawade, R., Patil, S., Martanto, E., Aprami, T.M., Purnomowati, A., Cool, C.J., Hasan, M., Akbar, R., Hidayat, S., Dewi, T.I., Permadi, W., Soedarsono, D.A., Ansari-Ramandi, M.M., Samiei, N., Tabib, A., Kashfi, F., Ansari-Ramandi, S., Rezaei, S., Farhan, H. Ali, Al-Hussein, A., Al-Saedi, G., Mahmood, G., Yaseen, I.F., Al-Yousuf, L., AlBayati, M., Mahmood, S., Raheem, S., AlHaidari, T., Dakhil, Z., Thornton, P., Donnelly, J., Bowen, M., Blatt, A., Elbaz-Greener, G., Shotan, A., Yalonetsky, S., Goland, S., Biener, M., Assenza, G. Egidy, Bonvicini, M., Donti, A., Bulgarelli, A., Prandstraller, D., Romeo, C., Crepaz, R., Sciatti, E., Metra, M., Orabona, R., Ali, L. Ait, Festa, P., Fesslova, V., Bonanomi, C., Calcagnino, M., Lombardi, F., Colli, A.M., Ossola, M.W., Gobbi, C., Gherbesi, E., Tondi, L., Schiavone, M., Squillace, M., Carmina, M.G., Maina, A., Macchi, C., Gollo, E., Comoglio, F.M., Montali, N., Re, P., Bordese, R., Todros, T., Donvito, V., Marra, W. Grosso, Sinagra, G., D'Agata Mottolese, B., Bobbo, M., Gesuete, V., Rakar, S., Ramani, F., Niwa, K., Mekebekova, D., Mussagaliyeva, A., Lee, T., Mirrakhimov, E., Abilova, S., Bektasheva, E., Neronova, K., Lunegova, O., Žaliūnas, R., Jonkaitienė, R., Petrauskaitė, J., Laucevicius, A., Jancauskaite, D., Lauciuviene, L., Gumbiene, L., Lankutiene, L., Glaveckaite, S., Laukyte, M., Solovjova, S., Rudiene, V., Chee, K.H., Yim, C.C.-W., Ang, H.L., Kuppusamy, R., Watson, T., Caruana, M., Estensen, M.-E., Kayani, M.G.A. Mahmood, Munir, R., Tomaszuk-Kazberuk, A., Sobkowicz, B., Przepiesc, J., Lesniak-Sobelga, A., Tomkiewicz-Pajak, L., Komar, M., Olszowska, M., Podolec, P., Wisniowska-Smialek, S., Lelonek, M., Faflik, U., Cichocka-Radwan, A., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Cruz, C., Ribeiro, V., Jovanova, S., Petrescu, V., Jurcut, R., Ginghina, C., Coman, I. Mircea, Musteata, M., Osipova, O., Golivets, T., Khamnagadaev, I., Golovchenko, O., Nagibina, A., Ropatko, I., Gaisin, I.R., Shilina, L. Valeryevna, Sharashkina, N., Shlyakhto, E., Irtyuga, O., Moiseeva, O., Karelkina, E., Zazerskaya, I., Kozlenok, A., Sukhova, I., Jovovic, L., Prokšelj, K., Koželj, M., Askar, A.O., Abdilaahi, A.A., Mohamed, M.H., Dirir, A.M., Sliwa, K., Manga, P., Pijuan-Domenech, A., Galian-Gay, L., Tornos, P., Subirana, M.T., T, M., Subirana, Oliver, J.M., Garcia-Aranda Dominguez, B., Gonzalez, I. Hernandez, Jimenez, J.F. Delgado, Subias, P. Escribano, Murga, N., Elbushi, A., Suliman, A., Jazzar, K., Murtada, M., Ahamed, N., Dellborg, M., Furenas, E., Jinesjo, M., Skoglund, K., Eriksson, P., Gilljam, T., Thilen, U., Tobler, D., Wustmann, K., Schwitz, F., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Lopes, B.M. Santos, Meier, L., Arrigo, M., de Boer, K., Konings, T., Wajon, E., Wagenaar, L.J., Polak, P., Pieper, E.P.G., Roos-Hesselink, J., van Hagen, I., Duvekot, H., Cornette, J.M.J., De Groot, C., van Oppen, C., Sarac, L., Esen, O. Batukan, Enar, S. Catirli, Mondo, C., Ingabire, P., Nalwanga, B., Semu, T., Salih, B.T., Almahmeed, W.A.R., Wani, S., Farook, F.S. Mohamed, Ain, Al, Gerges, F., Komaranchath, A.M., Al bakshi, F., Al Mulla, A., Yusufali, A.H., Al Hatou, E.I., Bazargani, N., Hussain, F., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Money-Kyrle, A., Clifford, P., Ramrakha, P., Firoozan, S., Chaplin, J., Bowers, N., Adamson, D., Schroeder, F., Wendler, R., Hammond, S., Nihoyannopoulos, P., Norfolk, Norwich, Hall, R., Freeman, L., Veldtman, G., Kerr, J., Tellett, L., Scott, N., Bhatt, A.B., DeFaria Yeh, D., Youniss, M.A., Wood, M., Sarma, A.A., Tsiaras, S., Stefanescu, A., Duran, J.M., Stone, L., Majdalany, D.S., Chapa, J., Chintala, K., Gupta, P., Botti, J., Ting, J., Davidson, W.R., Wells, G., Sparks, D., Paruchuri, V., Marzo, K., Patel, D., Wagner, W., Ahanya, S.N., Colicchia, L., Jentink, T., Han, K., Loichinger, M., Parker, M., Longtin, C., Yetman, A., Erickson, K., Cramer, J., Tsai, S., Fletcher, B., Warta, S., Cohen, C., Lindblade, C., Puntel, R., Nagaran, K., Croft, N., Gurvitz, M., Otto, C., Talluto, C., Murphy, D., Perlroth, M.G., Ramlakhan, Karishma P., Johnson, Mark R., Lelonek, Malgorzata, Saad, Aly, Gasimov, Zaur, Sharashkina, Natalia V., Thornton, Patrick, Arstall, Margaret, and Roos-Hesselink, Jolien W.

Published
2021
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48. Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease

Author

Stephen W. Bickler, David M. Cauvi, Kathleen M. Fisch, James M. Prieto, Alicia G. Sykes, Hariharan Thangarajah, David A. Lazar, Romeo C. Ignacio, Dale R. Gerstmann, Allen F. Ryan, Philip E. Bickler, and Antonio De Maio

Subjects
SARS-CoV-2, Pattern recognition receptors, Toll-like receptor 4, Aging, Skin fibroblasts, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Methods Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. Results Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. Conclusions Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels.

Published
2021
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50. Decision-Making in Pleural Drainage Following Lung Resection in Children: A Western Pediatric Surgery Research Consortium Survey.

Author

Schnuck, Jamie K., Acker, Shannon N., Kelley-Quon, Lorraine I., Lee, Justin H., Shew, Stephen B., Fialkowski, Elizabeth, Ignacio, Romeo C., Melhado, Caroline, Qureshi, Faisal G., Russell, Katie W., and Rothstein, David H.

Abstract

Studies of adults undergoing lung resection indicated that selective omission of pleural drains is safe and advantageous. Significant practice variation exists for pleural drainage practices for children undergoing lung resection. We surveyed pediatric surgeons in a 10-hospital research consortium to understand decision-making for placement of pleural drains following lung resection in children. Faculty surgeons at the 10 member institutions of the Western Pediatric Surgery Research Consortium completed questionnaires using a REDCap survey platform. Descriptive statistics and bivariate analyses were used to characterize responses regarding indications and management of pleural drains following lung resection in pediatric patients. We received 96 responses from 109 surgeons (88 %). Most surgeons agreed that use of a pleural drain after lung resection contributes to post-operative pain, increases narcotic use, and prolongs hospitalization. Opinions varied around the immediate use of suction compared to water seal, and half routinely completed a water seal trial prior to drain removal. Surgeons who completed fellowship within the past 10 years left a pleural drain after wedge resection in 45 % of cases versus 78 % in those who completed fellowship more than 10 years ago (p = 0.001). The mean acceptable rate of unplanned post-operative pleural drain placement when pleural drainage was omitted at index operation was 6.3 % (±4.6 %). Most pediatric surgeons use pleural drainage following lung resection, with recent fellowship graduates more often omitting it. Future studies of pleural drain omission demonstrating low rates of unplanned postoperative pleural drain placement may motivate practice changes for children undergoing lung resection. V. • What is currently known about this topic? Although adult trials have shown the safety and benefits of pleural drain omission following resectional lung surgery, few such trials exist in children. • What new information is contained in this article? Wide practice variations exist in pleural drain utilization and management, providing an opportunity for standardization of care and elimination of drains in a majority of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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