4 results on '"Romero del Rincón, Celia"'
Search Results
2. RE‐START: Exploring the effectiveness of anti‐calcitonin gene‐related peptide resumption after discontinuation in migraine.
- Author
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Romero del Rincón, Celia, Gonzalez‐Martinez, Alicia, Quintas, Sonia, García‐Azorín, David, Fernández Lázaro, Iris, Guerrero‐Peral, Angel Luis, Gonzalez Osorio, Yesica, Santos‐Lasaosa, Sonia, González Oria, Carmen, Sánchez Rodríguez, Norberto, Iglesias Díez, Fernando, Echavarría Íñiguez, Ana, Gil Luque, Sendoa, Huerta‐Villanueva, Mariano, Campoy Díaz, Sergio, Muñoz‐Vendrell, Albert, Lozano Ros, Alberto, Sánchez‐Soblechero, Antonio, Velasco Juanes, Fernando, and Kortazar‐Zubizarreta, Izaro
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PEPTIDES , *CALCITONIN gene-related peptide , *MIGRAINE , *TERMINATION of treatment , *MONOCLONAL antibodies - Abstract
Background and purpose: According to the latest European guidelines, discontinuation of monoclonal antibodies against calcitonin gene‐related peptide (anti‐CGRP MAb) may be considered after 12–18 months of treatment. However, some patients may worsen after discontinuation. In this study, we assessed the response following treatment resumption. Methods: This was a prospective study conducted in 14 Headache Units in Spain. We included patients with response to anti‐CGRP MAb with clinical worsening after withdrawal and resumption of treatment. Numbers of monthly migraine days (MMD) and monthly headache days (MHD) were obtained at four time points: before starting anti‐CGRP MAb (T‐baseline); last month of first treatment period (T‐suspension); month of restart due to worsening (T‐worsening); and 3 months after resumption (T‐reintroduction). The response rate to resumption was calculated. Possible differences among periods were analysed according to MMD and MHD. Results: A total of 360 patients, 82% women, with a median (interquartile range [IQR]) age at migraine onset of 18 (12) years. The median (IQR) MHD at T‐baseline was 20 (13) and MMD was 5 (6); at T‐suspension, the median (IQR) MHD was 5 (6) and MMD was 4 (5); at T‐worsening, the median (IQR) MHD was 16 (13) and MMD was 12 (6); and at T‐reintroduction, the median (IQR) MHD was 8 (8) and MHD was 5 (5). In the second period of treatment, a 50% response rate was achieved by 57.4% of patients in MHD and 65.8% in MMD. Multivariate models showed significant differences in MHD between the third month after reintroduction and last month before suspension of first treatment period (p < 0.001). Conclusion: The results suggest that anti‐CGRP MAb therapy is effective after reintroduction. However, 3 months after resumption, one third of the sample reached the same improvement as after the first treatment period. [ABSTRACT FROM AUTHOR]
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- 2024
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3. A new case of HTLV1 with rapidly progressive longitudinally extensive transverse myelitis: the importance of early diagnosis in therapeutic response
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Romero del Rincón, Celia, Pérez, Javier B., Barbosa del Olmo, Antonio, Bautista Hernandez, Azucena, Sánchez-Rodriguez, Carmen, and Quintas, Sonia
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- 2024
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4. Esclerosis múltiple: variabilidad estacional en medidas de resonancia magnética en Castellón
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Romero del Rincón, Celia, Belenguer Benavides, Antonio, and Universitat Jaume I. Unitat Predepartamental de Medicina.
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Actividad ,Climate ,Resonancia Magnética ,Grado en Medicina ,Seasonality ,Captación de contraste ,Relapsing-Remitting Multiple Sclerosis ,Magnetic Resonance Imaging ,Esclerosis Múltiple Remitente-Recurrente ,Activity ,Grau en Medicina ,Bachelor's Degree in Medicine ,Enhancing contrast ,Clima ,Estacionalidad - Abstract
Treball Final de Grau en Medicina. Codi: MD1158. Curs acadèmic: 2018/2019. Background and purpose: Research shows environmental factors play an important role in the development of Multiple Sclerosis (MS). Several studies have described seasonal variations in the disease's activity and that these could differ depending on the geographical area. The purpose of this study is to investigate if seasonal fluctuations of active Magnetic Resonance Imaging (MRI) lesions could be confirmed and whether any correlations could be detected in relapsingremitting MS patients from Castellon. Methods: A five year retrospective study analysis of 238 MRI from 51 patients. The clinical data was obtained from clinical histories in the University General Castellon Hospital and climatic data from Meteorological Estate Agency register between 2012 and 2016. MRI activity was defined as the appearance of new T2 lesions or gadolinium-enhancing lesions. Results: The frequency of enhancing lesions was significantly higher in July and August. However, no differences were identified in the appearance of new T2 lesions. Also, we found a higher risk of finding enhancing lesions in months with higher tropical nights, but not with other climatological factors. In addition, the tropical nights and RUV median was higher in MRIs with enhancing lesions only in some patients’ subgroups. Conclusions: We found significant seasonal variation of enhancing lesions, with peak activity in July and August. An increased risk of enhancing lesions was found in the months with more tropical nights. This is the first study to look into the effects of tropical nights. Along with other environmental factors, seasonal fluctuation contributes to MS activity. However, further work will be needed to identify additional environmental factors and to confirm our results. Introducción: Los factores ambientales parecen tener un papel importante en el desarrollo y el curso de la Esclerosis Múltiple (EM). Se ha descrito variabilidad estacional en la actividad de la enfermedad y se postula que podría variar en función del área geográfica. El objetivo de este estudio es analizar la distribución mensual de actividad observada en Resonancia Magnética (RM) y buscar una posible relación con el clima en los pacientes con EM Remitente Recurrente en el área sanitaria de Castellón. Material y métodos: Estudio retrospectivo realizado a partir de historias clínicas, informes radiológicos del Hospital General Universitario de Castellón y datos climatológicos de la Agencia Estatal de Meteorología registrados de 2012 a 2016. Fueron analizadas 238 RM de 51 pacientes. Se definió como actividad: lesiones captantes de contraste y aumento de lesiones en T2. Resultados: Encontramos un aumento significativo de la frecuencia de lesiones con captación en los meses de julio y agosto. La aparición de nuevas lesiones en T2 no mostró diferencias mensuales. Respecto el clima, las noches tropicales se asociaron con mayor riesgo de captación en la RM, además la mediana de noches tropicales y de radiación ultravioleta fue mayor en las RM captantes, sólo en algunos subgrupos de pacientes. Conclusiones: La aparición de lesiones captantes de contraste, como signo de actividad, ha demostrado seguir un patrón estacional, con aumento en julio y agosto. Se encontró un riesgo aumentado de captación en los meses con más noches tropicales, pero no con el resto de factores climáticos. Futuros estudios con planificación de las RM de cada paciente, muestras más amplias y mayor seguimiento son necesarios para confirmar nuestros resultados.
- Published
- 2019
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