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This paper presents the preliminary design of the international space mission HECATE (Human Exploration of Cis-lunar space via Assets Tele-operated from EML-2), aimed at exploring the far side of the Moon via tele-robotic activities during the 2020s. The exploration is realized by astronauts from HOPE (Human Orbiting Protected Environment), a space habitat in a halo orbit around the Earth-Moon Lagrange Point 2, a critical staging location for future robotic and human deep space missions. Inside the habitat, astronauts have access to tele-robotic hardware and instruments, used to tele-operate rovers and scientific equipment on the surface of the Moon. Plans to resupply and maintain HOPE for future missions, using a solar electric tug, are given. Ultimately, HOPE represents an energetically favorable intermediate locations for missions to Mars, Near-Earth Asteroids, and beyond. &nbsp

CAMELOT (Computational-Analytical Multi-fidelity Low-thrust Optimisation Toolbox) is a toolbox for the fast preliminary design and optimisation of low-thrust trajectories. It solves highly complex combinatorial problems to plan multi-target missions characterised by long spirals including different perturbations. In order to do so, CAMELOT implements a novel multi-fidelity approach combining analytical surrogate modelling and accurate computational estimations of the mission cost. Decisions are then made by using two pptimisation engines included in the toolbox, a single objective global optimiser and a combinatorial optimisation algorithm. CAMELOT has been applied to a variety of applications: from the design of interplanetary trajectories to the optimal deorbiting of space debris, from the deployment of constellations to on-orbit servicing. In this paper the main elements of CAMELOT are described and two space mission design problems solved using the toolbox are described.