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1. Telomere-based risk models for the early diagnosis of lung cancer

Author

Molina-Pinelo, Sonia, Ferrer Sánchez, Irene, Najarro, Pilar, Paz-Ares, Luis, Fernández, Luis, Castelló, Nila, Richart López, Luis Alberto, Rodríguez Gambarte, Juan Diego, Sanz García, Máximo, Salinas, Ana, Suárez, Rocío, Romero-Romero, Beatriz, Martín-Juan, José, Viñuela, María Eugenia, Butler, Ray G., and de Pedro, Nuria

Published
2024
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2. Malignant Pleural Effusion: A Multidisciplinary Approach

Author

Pardessus Otero, Ana, Rafecas-Codern, Albert, Porcel, José M., Serra-Mitjà, Pere, Ferreiro, Lucía, Botana-Rial, Maribel, Ramos-Hernández, Cristina, Brenes, José Manuel, Canales, Lydia, Camacho, Valle, Romero-Romero, Beatriz, Trujillo, Juan Carlos, Martinez, Elisabeth, Cases, Enrique, Barba, Andrés, Majem, Margarita, Güell, Ernest, and Pajares, Virginia

Published
2024
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8. Colaboradores

Author

Abajo Iglesias, Francisco J., Abalovich, Marcos S., Adamo, Bárbara, García-Navarro, Àlvar Agustí, García-Navarro, Carlos Agustí, Albarrán Artahona, Víctor, Alcalá Hernández, Luis, Alcaraz Asensio, Antonio, Alcázar Arroyo, Roberto, Alegre de Miquel, Víctor, Alejaldre Monforte, Aida, Almirante Gracera, Benito, del Pino Alonso Ortega, M.ª, Alonso Pérez, Manuel, Alonso-Tarrés, Carles, Manrique de Lara, Laia Alsina, Álvarez Larrán, Alberto, Álvarez-Martínez, Miriam José, Álvarez-Sala Walther, José Luís, Álvarez-Twose, Iván, Ambrosioni Czyrco, Juan, Amor Fernández, Antonio J., Ancochea Bermúdez, Julio, Andrade Bellido, Raúl, Andrés Collado, Mariano, Antón López, Jordi, Antón Nieto, Esperanza, Aran Perramon, Josep M.ª, Arance Fernández, Ana M.ª, Arias Gómez, Manuel, Arias Rivas, Susana, Arismendi Núñez, Ebymar, Ariza Cardenal, Xavier, Armengol Dulcet, Lluís, Aróstegui Gorospe, Juan Ignacio, Arranz Amo, José Antonio, Arrese, Marco, Audí Parera, Laura, Aulinas Masó, Anna, Badia Jobal, Joan Ramon, Badimon Maestro, Lina, Baena Caparrós, Jacinto, Baenas Soto, Isabel M.ª, Baeza Pertegaz, Inmaculada, Balcells Oliveró, Mercè, Martínez de Irujo, Jaume Baldirà, Barbé Illa, Ferran Eduard, Barberà Mir, Joan Albert, Barberán López, José, Barile Fabrís, Leonor A., Bartra Tomás, Joan, Bassas Arnau, Lluis, Bassat, Quique, Basté Rotllan, Neus, Bataller Alberola, Luis, Bataller Alberola, Ramón, Berdasco Menéndez, María, Bernabeu Morón, Ignacio, Berraondo López, Pedro, Berzigotti, Annalissa, Biagetti, Betina, Bielsa Marsol, Isabel, Blanco Amil, Carla L., Blanco Arévalo, José Luis, Blanco García, Francisco Javier, Blanco Vich, Isabel, Blasco Pelicano, Miquel, Bodro Marimont, Marta, Boronat Guerrero, Susana, Borrego Rabasco, Francisco, Bouza Santiago, Emilio, Brito Zerón, Pilar, Brugada Terradellas, Josep, Brugaletta, Salvatore, Bruix Tudó, Jordi, Bruna Escuer, Jordi, Buján Rivas, Segundo, Fernández de Piérola, Luis Bujanda, Buti Ferret, Maria, Cabellos Mínguez, Carmen, Cahn, Pedro E., Calvet Calvo, Xavier, Calvo Escalona, Rosa, Calvo González, Xavier, Campins Martí, Magda, Campistol Plana, Josep M.ª, Campo Güerri, Elías, Campuzano Larrea, Óscar, Campuzano Uceda, Victoria, Cardellach López, Francesc, Cardoner Alvárez, Narcís, Cardozo Espínola, Celia G., Carmena Rodríguez, Rafael, Carmona Herrera, Francisco, Carracedo Álvarez, Ángel, Carracedo Pérez, Arkaitz, Carreño Serrano, Mar, Carreres Mola, Anna, Casabona i Barbarà, Jordi, Casademont Pou, Jordi, Casanueva Freijo, Felipe F., Casas García, Irma, Cases Amenós, Aleix, Castells Garangou, Antoni, Castelo-Branco, Camil, Castón Osorio, Juanjo, Castro Fornieles, Josefina, Castro Rebollo, Pedro, Catalán Eraso, Beatriz, Caylà Buqueras, Joan, Cervera Álvarez, Carlos, Cervera Segura, Ricard, Chamorro Sánchez, Ángel, Cinta Cid Xutglà, M.ª, Cigudosa García, Juan C., José Coll Rosell, M.ª, Colmenero Arroyo, Jordi, Compta Hirnyj, Yaroslau, Conde Blanco, Estefanía, Corell Almuzara, Alfredo, Cortés Vicente, Elena, Crespo Casal, Manuel, Crespo Conde, Gonzalo, Crespo García, Javier, Cristófol Allué, Ramón, Cubiella Fernández, Joaquín, Cuenca Estrella, Manuel, Dalmases Cleries, Mireia, Dalmau Obrador, Josep, de Frutos Seminario, Fernando, de la Sierra Iserte, Alejandro, de Madaria Pascual, Enrique, del Campo Casanelles, Miguel, Dolores del Olmo García, M.ª, del Río Bueno, Ana, Delgado González, Julio, Diekmann, Fritz, Domínguez Benítez, José Antonio, Domínguez García, Ángela, Domínguez Luengo, Carmen, Ángeles Domínguez Luzón, M.ª, Jesús Domínguez Tordable, M.ª, Dopazo Blázquez, Joaquín, Dueñas Laita, Antonio, Eduardo Durán Rebolledo, Carlos, Duró Pujol, Joan Carles, Echevarría Mayo, Juan Emilio, Eiros Bouza, José M.ª, Ignasi Elizalde Frez, J., Embid López, Cristina, Engel Rocamora, Pablo, de Salamanca Lorente, Rafael Enríquez, España Alonso, Agustín, Espígol-Frigolé, Georgina, Esteller Badosa, Manel, Esteve Comas, María, Esteve Reyner, Jordi, Estruch Riba, Ramón, Feliu Sánchez, Jesús, Fernández Bañares, Fernando, Fernández Fernández, Óscar, Fernández Gómez, Javier, Fernández Llama, Patricia, Fernández Pombo, Antía, Ferrer Monreal, Miguel, Figuerola Pino, Daniel, Fillat Fonts, Cristina, Fonollosa Pla, Vicent, Fontanellas Romà, Antonio, Forcada Vega, Carme, Forner González, Alejandro, Forns Bernhardt, Xavier, Fortuny Guasch, Claudia, Franco de Castro, Agustín, de la Vega, Irene Fuertes, Fullana Rivas, Miquel Àngel, Gaba García, Lydia, Gaig Ventura, Carles, Galarza Delgado, Dionicio Ángel, Galicia Paredes, Miguel, Gállego Culleré, Montserrat, García de Vinuesa, Pastora Gallego, García Lareo, Manuel, García-Moncó, Juan Carlos, García Nieto, Víctor Manuel, García Olivé, Ignasi, Carlos García-Pagán, Juan, García Pavía, Pablo, García Rizo, Clemente, García Sánchez, José Elías, García-Vidal, C., García Villoria, Julia, Garrabou Tornos, Glòria, Garrido Marín, Eduardo, Gascón i Brustenga, Joaquim, Gatell Artigas, José M.ª, Gaya Valls, Anna, Gaztambide Sáenz, Sonia, Genescà Ferrer, Joan, Giavina-Bianchi, Pedro, Gil Rodríguez, Almudena, Giménez Pérez, Montserrat, Giné Soca, Eva, Ginés Gibert, Pere, Goday Arnó, Alberto, Gómez Balaguer, Marcelino, Gómez-Batiste Alentorn, Xavier, Gómez Bueno, Manuel, Gómez Dantés, Héctor, Gomollón García, Fernando, González Argenté, Francesc Xavier, González Juanatey, José Ramón, González Macías, Jesús, González Martín, Julià, Gracia Guillén, Diego Miguel, Grande i Fullana, Iria, Grau Junyent, Josep M.ª, García-Milà, Isabel Graupera, Graus Ribas, Francesc, Guañabens Gay, Nuria, Guasch Casany, Eduard, Gurguí Ferrer, Mercè, Ponce de León, Fernando Gutiérrez, Alexandra Hanzu, Felicia, Hawkins Carranza, Federico, Hernández Boluda, Juan Carlos, Hernández García, Miguel Teodoro, Hernández-Gea, Virginia, Hernández Rodríguez, José, Herrero Santos, José Ignacio, Ibáñez Toda, Lourdes, Iranzo de Riquer, Alejandro, Jiménez Castro, David, Juan Otero, Manuel, Juanola Roura, Xavier, Kalil, Jorge, Khamashta, Munther, Labarca Labarca, Jaime, Laborde García, Amalia, Lamas Oliveira, Cristina, Lanas Arbeloa, Ángel, Landete Rodríguez, Pedro, Larrosa Escartín, Nieves, Lázaro García, Luisa, Lens García, Sabela, Lleó Bisa, Alberto, Carlota Londoño Hurtado, M.ª, Bernaldo de Quirós, Juan Carlos López, López Granados, Eduardo, López Guillermo, Armando, López Meseguer, Manuel, López-Soto, Alfonso, López-Vélez Pérez, Rogelio, Lozano Mejorada, Rebeca, Lozano Sánchez, Francisco. S., Lozano Soto, Francisco, Luján Torné, Manuel, Lumbreras Bermejo, Carlos, Mallolas Masferrer, Josep, Manzanera López, Rafael, Mañá Rey, Juan, Marco Reverté, Francesc, Ángeles Marcos Maeso, M.ª, Marimón Ortiz de Zárate, José M.ª, Mariño Méndez, Zoe, Maroñas Amigo, Olalla, Marrades Sicart, Ramon, de la Iglesia, Jaume Marrugat, José Martí Domènech, M.ª, Martí Mestre, Xavier, Martí Ripoll, Mercè, Cristina Martín Sierra, M.ª, Díaz-Guerra, Guillermo Martínez, Martínez Lavín, Manuel, Martínez Martínez, José Antonio, Martínez Valle, Fernando, Martínez Vea, Alberto, Martínez Yoldi, Miguel Julián, Masana Marín, Lluís, Mascaró Galy, José Manuel, Matas Andreu, Lurdes, Mateo Soria, Lourdes, Victoria Mateos Manteca, M.ª, Maurel Santasusana, Joan, Melero Bermejo, Ignacio, Melero Maseda, Marcelo José, Mensa Pueyo, José, Mensa Vilaró, Anna, Mercé Klein, Jordi, Mestres Alomar, Gaspar, Mezquita Pérez, Laura, Milà Recasens, Montserrat, Milisenda, José, Milone, Jorge H., Miralles Basseda, Ramón, Miralles Hernández, Manuel, Miró Meda, Josep M.ª, Mòdol Deltell, Josep M.ª, Molero Richard, Xavier, Molina Infante, Javier, Molina Molina, María, Molins López-Rodó, Laureano, Mont Girbau, Josep Lluís, Montoro Huguet, Miguel Ángel, Montoya González, María, Mora Porta, Mireia, Morales-Olivas, Francisco, Morales Romero, Blai, Morán Chorro, Indalecio, Morata Ruiz, Laura, Asunción Moreno Camacho, M.ª, Muga Bustamante, Roberto, Muñoz Almagro, Carmen, Muñoz Bermúdez, Rosana, Muñoz Gall, Xavier, Esteban Muñoz García, José, Muñoz García-Paredes, Patricia, Muñoz Gutiérrez, José, Muñoz Mateu, Monserrat, Muñoz Villegas, Álvaro, Murillo Rubio, Óscar, África Muxí Pradas, M.ª, Navarro Acebes, Xavier, Navarro Otano, Judith, Nicolás Arfelis, Josep M.ª, Nolla Solé, Joan Miquel, Norman, Francesca F., Obach Baurier, Víctor, Tomás Obrador Vera, Gregorio, Oliva Dámaso, Elena, Olivé Plana, Montserrat, Oriola Ambrós, Josep, Ortiz Arduan, Alberto, de Lejarazu Leonardo, Raúl Ortiz, Oteo Revuelta, José Antonio, Palau Martínez, Francesc, Pallarés Giner, Román, Palou Rivera, Eduard, Paredes Deiros, Roger, Parramon Puig, Gemma, Pascal Capdevila, Mariona, Pascual Gómez, Eliseo, Pascual Gómez, Julio, Pascual Mateos, Juan Carlos, Pedro-Botet Montoya, Juan, Luisa Pedro-Botet Montoya, M.ª, Pereira Saavedra, Arturo, Pérez Gisbert, Javier, Picado Puig, Albert, Picó Alfonso, Antonio, Pigrau Serrallach, Carlos, Jesús Pinazo Delgado, M.ª, Pintado García, Vicente, Pintor Pérez, Luis, Pintos Morell, Guillem, Piñeiro Sánchez, Daniel José, Piqueras Carrasco, Josep, Plaza Moral, Vicente, López de Briñas, Esteban Poch, Pons-Estel, Bernardo A., Pons-Estel, Guillermo J., Pons Lladó, Guillem, Porcel Pérez, José Manuel, Pozo-Rosich, Patricia, Praga Terente, Manuel, de Medicina, Catedrático, de Medicina, Facultad, Complutense de Madrid, Universidad, Prat Aparicio, Aleix, Prat Marín, Andrés, Puig Domingo, Manuel, Pulido Mestre, Marta, Pumarola Suñé, Tomás, Puras Mallagray, Enrique, Queiro Silva, Rubén, Quintana Porras, Luis F., Quintero Carrión, Enrique, Adrián Rabinovich, Gabriel, Rabionet Janssen, Raquel, Ramos Casals, Manuel, Antoni Ramos Quiroga, J., Raya Sánchez, José M.ª, José Rego Castro, M.ª, Reig Monzón, María, Reig Torras, Óscar, Reverter Calatayud, Joan Carles, Reverter Calatayud, Jorge Luis, Reverter Segura, Enric, Reyes Cabanillas, Roxana, Reyes Moreno, José, Riambau Alonso, Vicenç, Ribera Casado, José Manuel, Ribera Santasusana, Josep M.ª, Ribes Rubió, Antonia, Ricart Gómez, Elena, Rico Caballero, Verónica, Robert Boter, Neus, Roca Lecumberri, Alba, Roca Luque, Ivo, Roca Torrent, Josep, Roche Rebollo, Enric, Gonzalo de Liria, Carlos Rodrigo, Rodríguez Baño, Jesús, de Castro, Felipe Rodríguez, Rodríguez Pérez, José Carlos, Rodríguez-Revenga, Laia, Rodríguez-Valero, Natalia, Roé Crespo, Esther, Rojas García, Ricardo, Romero-Gómez, Manuel, Romero Romero, Beatriz, Ros Cerro, Cristina, Rosiñol Dachs, Laura, Rovira Cañellas, Àlex, Rozman, Ciril, Rozman Jurado, María, Teresa Ruiz Cantero, M.ª, Ruiz Manzano, Juan, Ruiz Moreno, Javier, Ortiz de Arizabaleta, Estíbaliz Ruiz, Sabaté Tenas, Manel, Sáiz Hinarejos, Albert, Sala Sanjaume, Joan, Salgado García, Emilio José, Salinas Vert, Isabel, del Valle Díaz, Raquel Sánchez, Sánchez González, Marcelo, Sanmartí Sala, Raimon, Sanz Alonso, Miguel Ángel, Saperas Franch, Esteban, Saurí Nadal, Tamara, Schwarzstein, Diego, Segovia Cubero, Javier, Segura Egea, Antònia, Segura Porta, Ferran, Sellarés Torres, Jacobo, Selva O’Callaghan, Albert, Serra Majem, Lluís, Serra Pueyo, Jordi, Serrano Gimaré, Mercedes, Sibila Vidal, Oriol, Sierra Gil, Jorge, Sierra Romero, Gustavo Adolfo, Sionis, Alessandro, Sitges Carreño, Marta, Solà Vergès, Elsa, Solana Lara, Rafael, Solans Laqué, Roser, Gloria Soldevila Melgarejo, M.ª, Soler Porcar, Néstor, Sopena Galindo, Nieves, Soriano Viladomiu, Álex, Soy Muner, Dolores, Suárez Fernández, Ricardo, Suela Rubio, Javier, Targarona Soler, Eduardo M.ª, Tolosa Sarró, Eduardo, Tornero Molina, Jesús, Tornos Mas, Pilar, Torra Balcells, Roser, Torregrosa Prats, José Vicente, Torres Hortal, Montserrat, Torres Martí, Antonio, Torres Ramírez, Armando, Trilla García, Antoni, Trujillo Reyes, Juan Carlos, Tuca Rodríguez, Albert, Tudela Hita, Pere, Urbano Ispizua, Álvaro, Urra Nuin, Xabier, de Diego, Agustín Urrutia, Valero Santiago, Antonio L., Vallderiola Serra, Francesc, Valle Velasco, Laura, Vallés Angulo, Sara, Vaquero Raya, Eva, Vargas Núñez, Juan Antonio, Varsavsky, Mariela, Vázquez Martínez, Clotilde, San Miguel, Federico Vázquez, Vergara Gómez, Andrea, Vicente García, Vicente, Vidal Bermúdez, José Ernesto, Vidal Losada, María, Vidal-Puig, Antonio, Vieta Pascual, Eduard, Vila Estapé, Jordi, Vilabona Artero, Carles, Vilardell Tarrés, Miquel, Vilaseca González, Isabel, Vilella i Morató, Anna, Villà Freixa, Salvador, Villamor Casas, Neus, Vives Corrons, Joan Lluís, Vives Pi, Marta, Volberg Vincent, Verónica Inés, Vollmer Torrubiano, Ivan, Webb Youdale, Susan, Yagüe Ribes, Jordi, and Yugueros Castellnou, Xavier

Published
2024
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16. Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care

Author

Asociación de Neumología y Cirugía Torácica del Sur (España), Álvarez Gutiérrez, Francisco Javier, Ferrer Galván, Marta, Medina Gallardo, Juan Francisco, Barrera Mancera, Marta, Romero-Romero, Beatriz, Romero-Falcon, Auxiliadora, Asociación de Neumología y Cirugía Torácica del Sur (España), Álvarez Gutiérrez, Francisco Javier, Ferrer Galván, Marta, Medina Gallardo, Juan Francisco, Barrera Mancera, Marta, Romero-Romero, Beatriz, and Romero-Falcon, Auxiliadora

Abstract

[Background] Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care., [Methods] Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded. Univariate analysis was used to compare data from patients presenting at least 1 SE or ME during the follow-up period vs no exacerbations. Statistically significant (p <0.1) factors were then subjected to multiple analysis by binary logistic regression., [Results] A total of 330 patients completed the study, most of whom were atopic (76%), women (nearly 70%), with moderate and mild persistent asthma (>80%). Twenty-seven patients (8%) had a SE and 183 had a ME (58.5%) during follow-up. In the case of SEs, the only predictive factor identified in the multiple analysis was previous SE (baseline visit OR 4.218 95% CI 1.53-11.58, 4-month follow-up OR 6.88 95% CI 2.018-23.51) and inhalation technique (OR 3.572 95% CI 1.324-9.638). In the case of MEs, the only predictive factor found in the multiple analysis were previous ME (baseline visit OR 2.90 95% CI 1.54-5.48, 4-month follow- up OR 1.702 95% CI 1.146-2.529)., [Conclusions] The primary predictive factor for SE or ME is prior SE or ME, respectively. SEs seem to constitute a specific patient "phenotype", in which the sole predictive factor is prior SEs.

Published
2017

20. Evaluación de una estrategia para el control de la tuberculosis en un distrito sanitario de Andalucía

Author

Luna Sánchez, Antonio, Romero Romero, Beatriz, Expósito García, Sebastián, and Mata Martín, Ana María

Subjects
Evaluación, Programme, Programa, Tuberculosis, Enfermedades transmisibles, Communicable diseases, Evaluation
Abstract

Fundamento: La tuberculosis en España y Andalucía presenta tasas de incidencia por encima de las de países de nuestro entorno. Muchos autores señalan la necesidad de mejorar la información epidemiológica, la organización de los servicios sanitarios y el apoyo social a los pacientes. El objetivo de este trabajo es evaluar los resultados de una estrategia que contemplaba los tres elementos reseñados en un Distrito de Atención Primaria de Andalucía. Métodos: Se realizó el seguimiento a 234 enfermos de tuberculosis residentes en el Distrito y notificados al Sistema de Vigilancia Epidemiológica de Andalucía durante el período 2004-2008. Se consideraron como indicadores de evaluación el porcentaje que finalizó el tratamiento, el porcentaje de pacientes bacilíferos con estudio de contactos, los nuevos casos detectados en los mismos y la incidencia en menores de 15 años. Resultados: De los 234 pacientes incluidos se realizó un seguimiento efectivo en el 95%, de ellos finalizaron el tratamiento 182 (78%), fallecieron 18, se trasladaron de domicilio 10 y continuaban aún en tratamiento12. De los 130 casos que presentaron baciloscopia positiva se estudiaron a los contactos de 112 (el 86%). Se detectaron 27 nuevos casos entre los contactos estudiados y la incidencia anual en menores de 15 años fue del 6.65 por 100.000. Las perdidas del seguimiento se redujeron un 30% y las finalizaciones del tratamiento y los estudios de contactos mejoraron un 25% y 30% respectivamente, respecto a los datos del conjunto de Andalucía. Conclusiones: La estrategia seguida ha permitido mejorar los indicadores de evaluación propuestos. El % de casos nuevos detectados en los estudios de contactos y la incidencia anual en menores de 15 años ha sido similar en este estudio que en Andalucía. Background: Tuberculosis in Spain and Andalusia, the incidence rates above those of surrounding countries. Many authors emphasize the need for improved epidemiological information, the organization of health services and social support to patients. The aim of this study was to evaluate the results obtained after developing a strategy involving the three elements outlined in the Primary Care District of Andalusia. Methods: We followed up to 234 TB patients residing in the District and reported to the Epidemiological Surveillance System of Andalusia during the period 2004-2008. Were considered as indicators for evaluating the percentage of patients who completed treatment, the percentage of smear-positive contacts with study, new cases detected in the same and the incidence in children under 15 years. Results: Of the 234 patients were followed up cash 95% of them completed treatment 182 (78%) died 18, moved from home, 10 and 12 still remained in treatment. Of the 130 cases that presented positive sputum studied 112 contacts (86%). 27 new cases were detected among the contacts studied, and the annual incidence in children under 15 years was 6.65 per 100,000 population. Tracking losses were reduced by 30%, and terminations of treatment and contact studies improved by 25% and 30% respectively compared to data from the whole of Andalusia. Conclusions: The strategy has helped improve the proposed assessment indicators. The% of new cases detected in studies of contacts and the annual incidence in children under 15 years was similar in this study than in Andalusia.

Published
2010

21. Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care.

Author

Álvarez Gutiérrez, Francisco Javier, Ferrer Galván, Marta, Medina Gallardo, Juan Francisco, Barrera Mancera, Marta, Romero Romero, Beatriz, Romero Falcon, Auxiliadora, Gutiérrez, Francisco Javier Álvarez, Galván, Marta Ferrer, Gallardo, Juan Francisco Medina, Mancera, Marta Barrera, Romero, Beatriz Romero, and Falcón, Auxiliadora Romero

Subjects
ASTHMA, PREDICTIVE tests, PREVENTIVE medicine, OUTPATIENT medical care, ASTHMATICS, DRUG therapy for asthma, BRONCHODILATOR agents, LONGITUDINAL method, LOGISTIC regression analysis, SEVERITY of illness index, DISEASE progression, THERAPEUTICS
Abstract

Background: Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care.Methods: Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded. Univariate analysis was used to compare data from patients presenting at least 1 SE or ME during the follow-up period vs no exacerbations. Statistically significant (p <0.1) factors were then subjected to multiple analysis by binary logistic regression.Results: A total of 330 patients completed the study, most of whom were atopic (76%), women (nearly 70%), with moderate and mild persistent asthma (>80%). Twenty-seven patients (8%) had a SE and 183 had a ME (58.5%) during follow-up. In the case of SEs, the only predictive factor identified in the multiple analysis was previous SE (baseline visit OR 4.218 95% CI 1.53-11.58, 4-month follow-up OR 6.88 95% CI 2.018-23.51) and inhalation technique (OR 3.572 95% CI 1.324-9.638). In the case of MEs, the only predictive factor found in the multiple analysis were previous ME (baseline visit OR 2.90 95% CI 1.54-5.48, 4-month follow- up OR 1.702 95% CI 1.146-2.529).Conclusions: The primary predictive factor for SE or ME is prior SE or ME, respectively. SEs seem to constitute a specific patient "phenotype", in which the sole predictive factor is prior SEs. [ABSTRACT FROM AUTHOR]

Published
2017
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22. Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage

Author

Universidad de Sevilla. Departamento de Medicina, Pastor, María Dolores, Nogal, Ana, Molina Pinelo, Sonia, Meléndez, Ricardo, Romero-Romero, Beatriz, Mediano, Maria Dolores, Paz Ares, Luis, Lopez-Campos Bodineau, Jose Luis, Universidad de Sevilla. Departamento de Medicina, Pastor, María Dolores, Nogal, Ana, Molina Pinelo, Sonia, Meléndez, Ricardo, Romero-Romero, Beatriz, Mediano, Maria Dolores, Paz Ares, Luis, and Lopez-Campos Bodineau, Jose Luis

Abstract

Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC. Cigarette smoke causes oxidative stress and an inflammatory response in lung cells, which in turn may be involved in COPD and lung cancer development. The aim of this study was to identify differential proteomic profiles related to oxidative stress response that were potentially involved in these two pathological entities. Protein content was assessed in the bronchoalveolar lavage (BAL) of 60 patients classified in four groups: COPD, COPD and LC, LC, and control (neither COPD nor LC). Proteins were separated into spots by two dimensional polyacrylamide gel electrophoresis (2D-PAGE) and examined by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF). A total of 16 oxidative stress regulatory proteins were differentially expressed in BAL samples from LC and/or COPD patients as compared with the control group. A distinct proteomic reactive oxygen species (ROS) protein signature emerged that characterized lung cancer and COPD. In conclusion, our findings highlight the role of the oxidative stress response proteins in the pathogenic pathways of both diseases, and provide new candidate biomarkers and predictive tools for LC and COPD diagnosis.

Published
2013

23. Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage

Author

Instituto de Salud Carlos III, Fundação para a Ciência e a Tecnologia (Portugal), Pastor, María Dolores, Nogal, Ana, Molina-Pinelo, Sonia, Meléndez Cadenas, Ricardo, Romero-Romero, Beatriz, Mediano, María Dolores, López-Campos, J. L., García-Carbonero, Rocío, Sánchez-Gastaldo, Amparo, Carnero, Amancio, Paz-Ares, Luis, Instituto de Salud Carlos III, Fundação para a Ciência e a Tecnologia (Portugal), Pastor, María Dolores, Nogal, Ana, Molina-Pinelo, Sonia, Meléndez Cadenas, Ricardo, Romero-Romero, Beatriz, Mediano, María Dolores, López-Campos, J. L., García-Carbonero, Rocío, Sánchez-Gastaldo, Amparo, Carnero, Amancio, and Paz-Ares, Luis

Abstract

Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC. Cigarette smoke causes oxidative stress and an inflammatory response in lung cells, which in turn may be involved in COPD and lung cancer development. The aim of this study was to identify differential proteomic profiles related to oxidative stress response that were potentially involved in these two pathological entities. Protein content was assessed in the bronchoalveolar lavage (BAL) of 60 patients classified in four groups: COPD, COPD and LC, LC, and control (neither COPD nor LC). Proteins were separated into spots by two dimensional polyacrylamide gel electrophoresis (2D-PAGE) and examined by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF). A total of 16 oxidative stress regulatory proteins were differentially expressed in BAL samples from LC and/or COPD patients as compared with the control group. A distinct proteomic reactive oxygen species (ROS) protein signature emerged that characterized lung cancer and COPD. In conclusion, our findings highlight the role of the oxidative stress response proteins in the pathogenic pathways of both diseases, and provide new candidate biomarkers and predictive tools for LC and COPD diagnosis. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Published
2013

24. Management of malignant pleural effusions

Author

Rodríguez-Panadero, F., Romero-Romero, Beatriz, Rodríguez-Panadero, F., and Romero-Romero, Beatriz

Abstract

PURPOSE OF REVIEW: Malignant pleural effusions (MPEs) are one of the most common problems faced by clinicians and, since there is no optimum treatment available, they deserve efforts aimed to improve their management. RECENT FINDINGS: We have reviewed the most recent articles regarding treatment of MPE, with special emphasis on pleurodesis and indwelling pleural catheter placement. Although iodopovidone, silver nitrate and doxycycline are useful, talc continues to be the most effective agent available for pleurodesis. Use of calibrated talc with large particle size is now firmly established, in order to prevent complications. Indwelling pleural catheters are gaining general acceptance, and they are currently a valid option for patients with lung entrapment or those who have a previous failed pleurodesis. Advances in translational medicine related to this topic are also described. SUMMARY: The above results may contribute to improve significantly management of patients with malignant pleural effusions, especially those with advanced disease who are not suitable for pleurodesis procedures. © 2011 Lippincott Williams & Wilkins, Inc.

Published
2011

25. Evaluación de una estrategia para el control de la tuberculosis en un distrito sanitario de Andalucia

Author

Romero Romero, Beatriz, Expósito García, Sebastián, Mata Martín, María, Luna Sánchez, Antonio, Romero Romero, Beatriz, Expósito García, Sebastián, Mata Martín, María, and Luna Sánchez, Antonio

Abstract

Fundamento: La tuberculosis en España y Andalucía presenta tasas de incidencia por encima de las de países de nuestro entorno. Muchos autores señalan la necesidad de mejorar la información epidemiológica, la organización de los servicios sanitarios y el apoyo social a los pacientes. El objetivo de este trabajo es evaluar los resultados de una estrategia que contemplaba los tres elementos reseñados en un Distrito de Atención Primaria de Andalucía. Métodos: Se realizó el seguimiento a 234 enfermos de tuberculosis residentes en el Distrito y notificados al Sistema de Vigilancia Epidemiológica de Andalucía durante el período 2004-2008. Se consideraron como indicadores de evaluación el porcentaje que finalizó el tratamiento, el porcentaje de pacientes bacilíferos con estudio de contactos, los nuevos casos detectados en los mismos y la incidencia en menores de 15 años. Resultados:.De los 234 pacientes incluidos se realizó un seguimiento efectivo en el 95%, de ellos finalizaron el tratamiento 182 (78%), fallecieron 18, se trasladaron de domicilio 10 y continuaban aún en tratamiento12. De los 130 casos que presentaron baciloscopia positiva se estudiaron a los contactos de 112 (el 86%). Se detectaron 27 nuevos casos entre los contactos estudiados y la incidencia anual en menores de 15 años fue del 6.65 por 100.000. Las perdidas del seguimiento se redujeron un 30% y las finalizaciones del tratamiento y los estudios de contactos mejoraron un 25% y 30% respectivamente, respecto a los datos del conjunto de Andalucía. Conclusiones: La estrategia seguida ha permitido mejorar los indicadores de evaluación propuestos. El % de casos nuevos detectados en los estudios de contactos y la incidencia anual en menores de 15 años ha sido similar en este estudio que en Andalucía.

Published
2010

27. Identification of Oxidative Stress Related Proteins as Biomarkers for Lung Cancer and Chronic Obstructive Pulmonary Disease in Bronchoalveolar Lavage

Author

Pastor, Maria, primary, Nogal, Ana, additional, Molina-Pinelo, Sonia, additional, Meléndez, Ricardo, additional, Romero-Romero, Beatriz, additional, Mediano, Maria, additional, López-Campos, Jose, additional, García-Carbonero, Rocío, additional, Sanchez-Gastaldo, Amparo, additional, Carnero, Amancio, additional, and Paz-Ares, Luis, additional

Published
2013
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29. Relación del test de control del asma (ACT) con la función pulmonar, niveles de óxido nítrico exhalado y grados de control según la Iniciativa Global para el Asma (GINA)

Author

Alvarez-Gutiérrez, Francisco Javier, primary, Medina-Gallardo, Juan Francisco, additional, Pérez-Navarro, Pablo, additional, Martín-Villasclaras, Juan José, additional, Martin Etchegoren, Bernardo, additional, Romero-Romero, Beatriz, additional, and Praena-Fernández, Juan Manuel, additional

Published
2010
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31. Estudio del valor de los marcadores biológicos en el líquido pleural como predictores de la evolución de un derrame pleural maligno

Author

Pérez Cano, Ramón, Rodríguez Panadero, F., Universidad de Sevilla. Departamento de Medicina, Romero Romero, Beatriz, Pérez Cano, Ramón, Rodríguez Panadero, F., Universidad de Sevilla. Departamento de Medicina, and Romero Romero, Beatriz

Abstract

La evolución de los derrames pleurales malignos no sigue un comportamiento uniforme en todos los casos. Ante este hecho nos planteamos la cuestión de si existe algún factor cuyo estudio en el líquido pleural que nos queda señalar a priori el comportamiento posterior del derrame, y por tanto la actitud a tomar ante el mismo (pleurodesis como aproximación inicial o no). Durante el período de siete años (año 1993 - 2000), hemos realizado un estudio prospectivo longitudinal, en el que han sido incluidos 100 pacientes con diagnóstico confirmado de derrame pleural neoplásico y con volumen de derrame inferior a 2/3 de un hemitórax. En todos los pacientes se realizaron toracocentesis evacuadores (en función de la clínica del paciente) con determinaciones de rutina en las muestras de líquido pleural extraídas: pH, glucosa, LDH, recuento celular total, proteínas totales, Dímero D y citología. La pleurodesis se indicó en los pacientes con significativa recurrencia del derrame. La pleurodesis fue realizada con talco (10 cc, aproximadamente 6 g de talco seco) mediante toracoscopia con anestesia local y analgesia parenteral. De los 100 pacientes incluidos en el estudio, 60 requirieron pleurodesis con talco en su evolución para controlar el derrame, los 40 pacientes restantes no fueron sometidos a esta técnica (26 de ellos por control del derrame de forma conservadora y los restantes 12 por su situación clínica terminal). Los pacientes que requirieron pleurodesis presentaron una disminución de las cifras de pH en las sucesivas toracocentesis realizadas (cáida de 0,002/día) y un aumento en las cifras de Dímero D también en las toracocentesis realizadas (0,09/día). En los pacientes en los que no se requirió pleurodesis para el control del derame, sucedió lo contrario (aumento de 0,003/día en las cifras de pH y caída de /día en las cifras de Dímero D). En el resto de parámetros estudiados no encontramos diferencias s

Published
2002

32. Is the bronchodilator test an useful tool to measure asthma control?

Author

Beatriz Romero Romero, Auxiliadora Romero Falcón, Antonia Sáez, Marta Ferrer Galván, Francisco Javier Álvarez Gutiérrez, Juan Francisco Medina Gallardo, [Ferrer Galvan, Marta] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain, [Alvarez Gutierrez, Francisco Javier] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain, [Romero Falcon, Auxiliadora] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain, [Romero Romero, Beatriz] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain, [Saez, Antonia] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain, and [Medina Gallardo, Juan Francisco] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Asthma Unit, Seville, Spain

Subjects
Pulmonary and Respiratory Medicine, Risk, Adult, Male, Vital capacity, medicine.medical_specialty, medicine.drug_class, Future risk, FEV1 reversibility, Lung-function, Nitric Oxide, Risk Assessment, Bronchial Provocation Tests, Fev1, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Reversibility, Predictive Value of Tests, Bronchodilator, Asthma control, Internal medicine, Forced Expiratory Volume, Medicine, Humans, 030212 general & internal medicine, Prospective Studies, Asthma, Trials, Univariate analysis, business.industry, Area under the curve, Disease Management, Attacks, Middle Aged, medicine.disease, respiratory tract diseases, Bronchodilator Agents, 030228 respiratory system, Test act, FEV(1) reversibility, Spirometry, Anesthesia, Cardiology, Female, business
Abstract

Introduction Asthma control includes the control of symptoms and future risk. We sought to evaluate the usefulness of the degree of spirometric reversibility of the forced expiratory volume in one second (FEV 1 ) as the target parameter of control. Methodology Patients with bronchial asthma were followed up for one year. The clinical, functional, inflammatory and control parameters of the asthma were collected. The area under the curve (AUC) was estimated to establish the cutoff point of the post-bronchodilator FEV 1 reversibility in relation to non-control asthma. In the univariate analysis, the differences between groups were studied based on the degree of estimated reversibility. Factors with a significance Results A total of 407 patients with a mean age of 38.1 ± 16.7 years were included. When the patients were grouped into controlled and non-controlled groups, compared with post-bronchodilator FEV 1 reversibility, the cutoff point obtained for the non-controlled group was ≥10% (sensitivity: 65.8%, specificity: 48.4%, positive predictive value: 69.5%, and AUC: 0.619 [0.533–0.700], p 1 ≥10), an increased use of relief medication was observed, along with a significantly progressive drop in post-bronchodilator FEV 1 and post-bronchodilator FEV 1 /FVC (forced expiratory volume in one second/forced vital capacity). Conclusions Spirometric reversibility can be useful in assessing control in asthmatic patients and can predict future risk parameters. The cutoff point related to the non-control of asthma found in our work was ≥10%.

Published
2016

33. MicroRNA clusters: dysregulation in lung adenocarcinoma and COPD.

Author

Molina-Pinelo S, Pastor MD, Suarez R, Romero-Romero B, González De la Peña M, Salinas A, García-Carbonero R, De Miguel MJ, Rodríguez-Panadero F, Carnero A, and Paz-Ares L

Subjects
Adenocarcinoma metabolism, Adenocarcinoma of Lung, Adult, Aged, Algorithms, Bronchoalveolar Lavage Fluid, Chromosome Mapping, Female, Gene Expression Profiling, Gene Regulatory Networks, Humans, Lung Neoplasms metabolism, Male, Middle Aged, Prospective Studies, Pulmonary Disease, Chronic Obstructive metabolism, Signal Transduction, Adenocarcinoma genetics, Gene Expression Regulation, Neoplastic, Lung Neoplasms genetics, MicroRNAs metabolism, Pulmonary Disease, Chronic Obstructive genetics
Abstract

Lung adenocarcinoma and chronic obstructive pulmonary disease (COPD) are pulmonary diseases that share common aetiological factors (tobacco smoking) and probable dysregulated pathways. MicroRNAs (miRNAs) play an essential role in regulating numerous physiological and pathological processes. The purpose of this study was to assess global miRNA expression patterns in patients with COPD and/or adenocarcinoma to elucidate distinct regulatory networks involved in the pathogenesis of these two smoking-related diseases. Expression of 381 miRNAs was quantified by TaqMan Human MicroRNA A Array v2.0 in bronchoalveolar lavage fluid samples from 87 patients classified into four groups: COPD, adenocarcinoma, adenocarcinoma with COPD, and control (neither COPD nor adenocarcinoma). 11 differentially expressed miRNAs were randomly selected for validation in an independent cohort of 40 patients. Distinct miRNA expression profiles were identified and validated for each pathological group, involving 66 differentially expressed miRNAs. Four miRNA clusters (the mir-17-92 cluster and its paralogues, mir-106a-363 and mir-106b-25; and the miR-192-194 cluster) were upregulated in patients with adenocarcinoma and one miRNA cluster (miR-132-212) was upregulated in patients with COPD. These results contribute to unravelling miRNA-controlled networks involved in the pathogenesis of adenocarcinoma and COPD, and provide new tools of potential use as biomarkers for diagnosis and/or therapeutic purposes., (©ERS 2014.)

Published
2014
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34. [Comparison of the Asthma Control Test (ACT) with lung function, levels of exhaled nitric oxide and control according to the Global Initiative for Asthma (GINA)].

Author

Alvarez-Gutiérrez FJ, Medina-Gallardo JF, Pérez-Navarro P, Martín-Villasclaras JJ, Martin Etchegoren B, Romero-Romero B, and Praena-Fernández JM

Subjects
Adolescent, Adult, Aged, Asthma drug therapy, Biomarkers, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Intradermal Tests, Male, Middle Aged, Outpatients statistics & numerical data, Predictive Value of Tests, Prospective Studies, ROC Curve, Sensitivity and Specificity, Young Adult, Asthma physiopathology, Breath Tests, Nitric Oxide analysis, Severity of Illness Index, Spirometry, Surveys and Questionnaires
Abstract

Introduction: The current goal of asthma treatment is to achieve and maintain control. This study aimed to explore the relationship between the ACT (Asthma Control Test) questionnaire and the levels of control according to GINA (Global Initiative for Asthma) to establish the cut-off points for the ACT and evaluate its relationship with lung function and fractionated exhaled nitric oxide level (FeNO)., Patients and Methods: A multi-centre prospective study including 441 patients followed up in an outpatient Chest Clinic. A clinical protocol was followed, and FeNO, spirometry and ACT performed. Disease was classified according to levels of control using GINA. The study analysed sensitivity, specificity and area under the curve (ROC), and the ACT cut-off points. We studied the differences between the functional parameters and FeNO between levels of control., Results: For controlled asthma the cut-off obtained was ACT> or =21 (area under the curve 0.791) and for uncontrolled < or =18 (AUC 0.774). We found significant differences in FeNO levels and pulmonary function among ACT> or =21 and ACT< or =18, although only 26.3% of patients with ACT< or =18 had a FEV1 <80% and 40% higher FeNO (> or =35 ppb). We found a correlation between baseline FEV1 and ACT (r=0.19, P<0.01) and between ACT and FeNO (r=-0.16, P<0.01)., Conclusions: The cut-off points would be, for controlled asthma ACT> or =21, partly controlled asthma ACT=19-20 and uncontrolled asthma ACT< or =18. A more complete assessment would require including monitoring operating parameters and FeNO., (Copyright 2010 SEPAR. Published by Elsevier Espana. All rights reserved.)

Published
2010
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35. [Evaluation of a strategy for the control of tuberculosis in a health district of andalusia, Spain].

Author

Luna Sánchez A, Romero Romero B, Expósito García S, and Mata Martín AM

Subjects
AIDS-Related Opportunistic Infections epidemiology, Adolescent, Adult, Age Factors, Aged, 80 and over, Child, Emigrants and Immigrants, Humans, Incidence, Middle Aged, Spain epidemiology, Time Factors, Tuberculosis diagnosis, Tuberculosis epidemiology, Tuberculosis mortality, Tuberculosis, Pulmonary diagnosis, Tuberculosis, Pulmonary epidemiology, Tuberculosis, Pulmonary mortality, Tuberculosis, Pulmonary prevention & control, Tuberculosis prevention & control
Abstract

Background: Tuberculosis in Spain and Andalusia, the incidence rates above those of surrounding countries. Many authors emphasize the need for improved epidemiological information, the organization of health services and social support to patients. The aim of this study was to evaluate the results obtained after developing a strategy involving the three elements outlined in the Primary Care District of Andalusia., Methods: We followed up to 234 TB patients residing in the District and reported to the Epidemiological Surveillance System of Andalusia during the period 2004-2008. Were considered as indicators for evaluating the percentage of patients who completed treatment, the percentage of smear-positive contacts with study, new cases detected in the same and the incidence in children under 15 years., Results: Of the 234 patients were followed up cash 95% of them completed treatment 182 (78%) died 18, moved from home, 10 and 12 still remained in treatment. Of the 130 cases that presented positive sputum studied 112 contacts (86%). 27 new cases were detected among the contacts studied, and the annual incidence in children under 15 years was 6.65 per 100,000 population. Tracking losses were reduced by 30%, and terminations of treatment and contact studies improved by 25% and 30% respectively compared to data from the whole of Andalusia., Conclusions: The strategy has helped improve the proposed assessment indicators. The% of new cases detected in studies of contacts and the annual incidence in children under 15 years was similar in this study than in Andalusia.

Published
2010
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