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1. StripeDiff: Model-based algorithm for differential analysis of chromatin stripe.

Author

Gupta, Krishan, Guangyu Wang, Shuo Zhang, Xinlei Gao, Rongbin Zheng, Yanchun Zhang, Qingshu Meng, Lili Zhang, Qi Cao, and Kaifu Chen

Subjects
*STRIPES, *LOGNORMAL distribution, *RNA polymerase II, *MESODERM
Abstract

The article highlights several studies which shows stripes as an architectural feature of three-dimensional chromatin and found stripes connected to epigenetic regulation of transcription. It discusses StripeDiff showed performance in both simulation data analysis and real Hi-C data analysis; applying StripeDiff to 12 sets of Hi-C data showed insights into connection between change of chromatin stripe and change of chromatin modification, transcriptional regulation, and cell differentiation.

Published
2022
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