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2. Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019

Author

Glans, Hedvig, Dotevall, Leif, Van der Auwera, Gert, Bart, Aldert, Blum, Johannes, Buffet, Pierre, Guery, Romain, Gangneux, Jean-Pierre, van Henten, Saskia, Harms, Gundel, Varani, Stefania, Robert-Gangneux, Florence, Rongisch, Robert, Andersson, Björn, and Bradley, Maria

Published
2022
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5. Harmonized procedure coding system for surgical procedures and analysis of surgical site infections (SSI) of five European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Al-Monajjed, Rouvier, Cornely, Florian B., Grosheva, Maria, Hampl, Jürgen A., Jakob, Carolin, Koehler, Felix C., Lechmann, Max, Maged, Bijan, Otto-Lambertz, Christina, Rongisch, Robert, Rutz, Jule, Salmanton-Garcia, Jon, Schlachtenberger, Georg, Stemler, Jannik, Vehreschild, Janne, Wülfing, Sophia, Cornely, Oliver A., and Liss, Blasius J.

Published
2022
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14. The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

Author

Hamdorf, Matthias, primary, Imhof, Thomas, additional, Bailey-Elkin, Ben, additional, Betz, Janina, additional, Theobald, Sebastian J, additional, Simonis, Alexander, additional, Di Cristanziano, Veronica, additional, Gieselmann, Lutz, additional, Dewald, Felix, additional, Lehmann, Clara, additional, Augustin, Max, additional, Klein, Florian, additional, Alcazar, Miguel A Alejandre, additional, Rongisch, Robert, additional, Fabri, Mario, additional, Rybniker, Jan, additional, Goebel, Heike, additional, Stetefeld, Jörg, additional, Brachvogel, Bent, additional, Cursiefen, Claus, additional, Koch, Manuel, additional, and Bock, Felix, additional

Published
2023
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15. Soft tissue infections

Author

Rongisch, Robert, Fabri, Mario, Rongisch, Robert, and Fabri, Mario

Abstract

Acute skin and soft tissue infections are among the most frequent infections in medicine. There is a broad spectrum including simple local infections as well as severe and life-threatening diseases. Along with Staphylococcus aureus, group A Streptococci are mainly responsible for these illnesses. The therapeutic approach ranges from antiseptic local treatments to administering systemic antibiotics or emergency surgery. Treating physicians often face challenges when presented with soft tissue infections due to a great discrepancy between the first impression of the disease compared to a possibly quick progression as well as the wide range of sometimes confusing historic terms and definitions being used in the English and German language, for instance pyoderma, erysipelas or phlegmon. A recently more popular collective term emphasized by clinical trials is acute bacterial skin and skin structure infections (ABSSSI).

Published
2022

17. Additional file 1 of Harmonized procedure coding system for surgical procedures and analysis of surgical site infections (SSI) of five European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Al-Monajjed, Rouvier, Cornely, Florian B., Grosheva, Maria, Hampl, Jürgen A., Jakob, Carolin, Koehler, Felix C., Lechmann, Max, Maged, Bijan, Otto-Lambertz, Christina, Rongisch, Robert, Rutz, Jule, Salmanton-Garcia, Jon, Schlachtenberger, Georg, Stemler, Jannik, Vehreschild, Janne, Wülfing, Sophia, Cornely, Oliver A., and Liss, Blasius J.

Abstract

Additional file 1.

Published
2022
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18. Harmonized procedure coding system for surgical procedures of five European countries (Preprint)

Author

Mellinghoff, Sibylle, primary, Bruns, Carolin, additional, Al-Monajjed, Rouvier, additional, Cornely, Florian, additional, Grosheva, Maria, additional, Hampl, Juergen, additional, Jakob, Carolin, additional, Koehler, Felix, additional, Lechmann, Max, additional, Maged, Bijan, additional, Otto-Lambertz, Christina, additional, Rongisch, Robert, additional, Rutz, Jule, additional, Salmanton-Garcia, Jon, additional, Schlachtenberger, Georg, additional, Stemler, Jannik, additional, Vehreschild, Janne, additional, Wuelfing, Sophia, additional, Cornely, Oliver, additional, and Liss, Blasius, additional

Published
2021
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19. Parasitic dermatoses from abroad

Author

Rongisch, Robert, Bopp, Luisa, Fabri, Mario, von Stebut, Esther, Rongisch, Robert, Bopp, Luisa, Fabri, Mario, and von Stebut, Esther

Abstract

Increased migration, the omnipresent desire to travel, climate change and a globally more mobile population enhance the risk of spreading infectious, tropical pathogens across international borders. In addition to diarrhea and fever, skin diseases present one of the most common reasons for a medical consultation upon return among travelers. These diseases are often caused by parasites. Detailed data on infectious travel diseases is scarce. However, demographic, endemic and travel-related information represent the basic requirements for physicians to choose appropriate diagnostics and adequate treatment for affected patients. This article gives an overview of common parasitic travel dermatoses, their specific diagnostic workup, treatment and preventive measures.

Published
2021

20. The Unique ORF8 Protein From SARS-CoV-2 Binds to Human Dendritic Cells and Induces a Hyper-Inflammatory Cytokine Storm

Author

Hamdorf, Matthias, primary, Imhof, Thomas, additional, Bailey-Elkin, Ben, additional, Betz, Janina, additional, Theobald, Sebastian J., additional, Simonis, Alexander, additional, Cristanziano, Veronica Di, additional, Gieselmann, Lutz, additional, Dewald, Felix, additional, Lehmann, Clara, additional, Augustin, Max, additional, Klein, Florian, additional, Alejandre Alcazar, Miguel A., additional, Rongisch, Robert, additional, Fabri, Mario, additional, Rybniker, Jan, additional, Stetefeld, Jörg, additional, Brachvogel, Bent, additional, Cursiefen, Claus, additional, Koch, Manuel, additional, and Bock, Felix, additional

Published
2021
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21. Infektiöse Reisedermatosen

Author

Rongisch, Robert, primary, Schmidt, Enno, additional, Deresz, Nicolai, additional, Deresz, Katharina, additional, Schöfer, Helmut, additional, Schäkel, Knut, additional, Jakob, Thilo, additional, Maurer, Marcus, additional, Sticherling, Michael, additional, Sunderkötter, Cord, additional, Babilas, Philipp, additional, Spornraft‐Ragaller, Petra, additional, Traidl‐Hoffmann, Claudia, additional, Gläser, Regine, additional, Hartmann, Karin, additional, Kolb‐Mäurer, Annette, additional, Wenzel, Jörg, additional, Biedermann, Tilo, additional, Homey, Bernhard, additional, Pfützner, Wolfgang, additional, Weid, Florian, additional, Fischer, Marcellus, additional, Linder, Roland, additional, and von Stebut, Esther, additional

Published
2020
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22. Travel‐associated infectious skin diseases

Author

Rongisch, Robert, primary, Schmidt, Enno, additional, Deresz, Nicolai, additional, Deresz, Katharina, additional, Schöfer, Helmut, additional, Schäkel, Knut, additional, Jakob, Thilo, additional, Maurer, Marcus, additional, Sticherling, Michael, additional, Sunderkötter, Cord, additional, Babilas, Philipp, additional, Spornraft‐Ragaller, Petra, additional, Traidl‐Hoffmann, Claudia, additional, Gläser, Regine, additional, Hartmann, Karin, additional, Kolb‐Mäurer, Annette, additional, Wenzel, Jörg, additional, Biedermann, Tilo, additional, Homey, Bernhard, additional, Pfützner, Wolfgang, additional, Weid, Florian, additional, Fischer, Marcellus, additional, Linder, Roland, additional, and von Stebut, Esther, additional

Published
2020
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23. Travel-associated infectious skin diseases

Author

Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, Stebut, Esthervon, Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, and Stebut, Esthervon

Published
2020

24. Emergencies in dermatology From gonorrhea to angioedema

Author

Neumayer, Daniela Stefanie, Rongisch, Robert, Kaestle, Judith, Neumayer, Daniela Stefanie, Rongisch, Robert, and Kaestle, Judith

Abstract

The spectrum of dermatological emergencies is diverse. Infections, in particular sexually transmitted infections, anaphylactic reactions, and cutaneous drug reactions are common causes for patients to present themselves to the dermatological emergency service. If a sexually transmitted infection is suspected, it is important for the physician to recognize which diseases need immediate treatment to avoid late complications. This requires a reliable diagnosis and knowledge of the appropriate therapy. Cutaneous drug reactions can take many forms. There is a spectrum of reactions that occur immediately after the administration of a medication (which manifest themselves as anaphylaxis), to those that can appear weeks after the initiation of a therapy. These reactions can be harmless and self-limiting, but also be life-threatening. It is essential for physicians in everyday clinical practice to recognize drug intolerances in time and to treat them appropriately.

Published
2020

27. Exanthema after travel abroad

Author

Hellmich, Luisa, Rongisch, Robert, Rasokat, Heinrich, von Stebut, Esther, Fabri, Mario, Hellmich, Luisa, Rongisch, Robert, Rasokat, Heinrich, von Stebut, Esther, and Fabri, Mario

Abstract

In view of globalization and the associated transport of goods as well as rising travel activity, imported infections with subtropical and tropical pathogens are increasing in Germany. In returning travelers presenting with fever, general symptoms and skin rash, a number of diseases need to be considered. The clinical appearance of the skin rash, accurate travel history and epidemiological information on country-specific risks are helpful in making the correct diagnosis. In this article we provide an overview of the most common exanthemas in travelers who have returned, associated symptoms, diagnostic methods, therapies, as well as prevention strategies.

Published
2019

28. Exanthema after Foreign Trips

Author

Hellmich, Luisa, Rongisch, Robert, Rasokat, Heinrich, von Stebut, Esther, Fabri, Mario, Hellmich, Luisa, Rongisch, Robert, Rasokat, Heinrich, von Stebut, Esther, and Fabri, Mario

Published
2019

30. Tofacitinib suppresses IL-10/IL-10R signaling and modulates host defense responses in human macrophages

Author

Knoke, Kristin, Rongisch, Robert R., Grzes, Katarzyna M., Schwarz, Roman, Lorenz, Beate, Yogev, Nir, Pearce, Erika L., Pearce, Edward J., Kofler, David M., and Fabri, Mario

Abstract

JAK inhibitors are increasingly used in dermatology. Despite broad inhibitory effects on cytokine signaling cascades, they only modestly increase the risk for infectious diseases. To address molecular mechanisms underlying this unexpected clinical observation, we investigated how tofacintib, a first-in-class JAK inhibitor, regulates host defense responses in TLR4-activated human macrophages. Specifically, we asked if tofacitinib inhibits anti-inflammatory IL-10 signaling, thereby counteracting downregulation of inflammatory, host-protective pathways. We found that tofacitinib blocked macrophage responses to IL-10 at the level of STAT3 phosphorylation. Furthermore, TLR4-induced, auto-/paracrine IL-10/IL-10R activation promoted expression of hepcidin, the master regulator of iron metabolism, resulting in intracellular iron sequestration. In contrast, auto-/paracrine IL-10/IL-10R activation repressed expression of cathelicidin antimicrobial peptide, as well as antigen-presenting molecules, thus together, inducing a pathogen-favoring environment. While tofacitinib further repressed cathelicidin, it prevented induction of intracellular hepcidin, and restored expression of antigen-presentation molecules in TLR4-activated macrophages. Our study supports the concept that induction of IL-10/IL-10R signaling drives a complex immune evasion strategy of intracellular microbes. Moreover, we conclude that tofacitinib has diverging effects on macrophage host response pathways, and we identify the TLR4-IL-10-STAT3-hepcidin axis as a potential therapeutic target to counteract immune evasion.

Published
2021
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31. Travel-associated infectious skin diseases

Author

Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, von Stebut, Esther, Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, and von Stebut, Esther

32. Travel-associated infectious skin diseases

Author

Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, von Stebut, Esther, Rongisch, Robert, Schmidt, Enno, Deresz, Nicolai, Deresz, Katharina, Schoefer, Helmut, Schaekel, Knut, Jakob, Thilo, Maurer, Marcus, Sticherling, Michael, Sunderkoetter, Cord, Babilas, Philipp, Spornraft-Ragaller, Petra, Traidl-Hoffmann, Claudia, Glaeser, Regine, Hartmann, Karin, Kolb-Maeurer, Annette, Wenzel, Joerg, Biedermann, Tilo, Homey, Bernhard, Pfuetzner, Wolfgang, Weid, Florian, Fischer, Marcellus, Linder, Roland, and von Stebut, Esther

33. The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.

Author

Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alejandre Alcazar MA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, and Bock F

Subjects
Humans, Cytokine Release Syndrome immunology, Cytokine Release Syndrome metabolism, Cell Adhesion Molecules metabolism, Cell Adhesion Molecules immunology, Receptors, Cell Surface metabolism, Protein Binding, Dendritic Cells immunology, Dendritic Cells metabolism, Dendritic Cells virology, SARS-CoV-2 immunology, SARS-CoV-2 metabolism, COVID-19 immunology, COVID-19 virology, COVID-19 metabolism, Cytokines metabolism, Lectins, C-Type metabolism, Lectins, C-Type immunology, Viral Proteins metabolism, Viral Proteins immunology
Abstract

The novel coronavirus pandemic, first reported in December 2019, was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection leads to a strong immune response and activation of antigen-presenting cells, which can elicit acute respiratory distress syndrome (ARDS) characterized by the rapid onset of widespread inflammation, the so-called cytokine storm. In response to viral infections, monocytes are recruited into the lung and subsequently differentiate into dendritic cells (DCs). DCs are critical players in the development of acute lung inflammation that causes ARDS. Here, we focus on the interaction of a specific SARS-CoV-2 open reading frame protein, ORF8, with DCs. We show that ORF8 binds to DCs, causes pre-maturation of differentiating DCs, and induces the secretion of multiple proinflammatory cytokines by these cells. In addition, we identified DC-SIGN as a possible interaction partner of ORF8 on DCs. Blockade of ORF8 leads to reduced production of IL-1β, IL-6, IL-12p70, TNF-α, MCP-1 (also named CCL2), and IL-10 by DCs. Therefore, a neutralizing antibody blocking the ORF8-mediated cytokine and chemokine response could be an improved therapeutic strategy against SARS-CoV-2., (© The Author(s) (2023). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS.)

Published
2024
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34. Infektiöse Reisedermatosen.

Author

Rongisch R, Schmidt E, Deresz N, Deresz K, Schöfer H, Schäkel K, Jakob T, Maurer M, Sticherling M, Sunderkötter C, Babilas P, Spornraft-Ragaller P, Traidl-Hoffmann C, Gläser R, Hartmann K, Kolb-Mäurer A, Wenzel J, Biedermann T, Homey B, Pfützner W, Weid F, Fischer M, Linder R, and von Stebut E

Published
2020
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35. Travel-associated infectious skin diseases.

Author

Rongisch R, Schmidt E, Deresz N, Deresz K, Schöfer H, Schäkel K, Jakob T, Maurer M, Sticherling M, Sunderkötter C, Babilas P, Spornraft-Ragaller P, Traidl-Hoffmann C, Gläser R, Hartmann K, Kolb-Mäurer A, Wenzel J, Biedermann T, Homey B, Pfützner W, Weid F, Fischer M, Linder R, and von Stebut E

Subjects
Humans, Travel, Travel Medicine, Travel-Related Illness, Skin Diseases, Skin Diseases, Infectious
Published
2020
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