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1. Erratum: Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group

Author

Maren Kummerow, Erica J. Shaddock, Kerstin Klipstein-Grobusch, Roos B. Barth, Diederick E. Grobbee, W.D. Francois Venter, Charles Feldman, and Alinda Vos

Subjects
no related keywords in the metadata., Public aspects of medicine, RA1-1270, Infectious and parasitic diseases, RC109-216
Abstract

No abstract available.

Published
2021
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2. Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group

Author

Maren Kummerow, Erica J. Shaddock, Kerstin Klipstein-Grobusch, Roos B. Barth, Diederick E. Grobbee, Francois D.F. Venter, Charles Feldman, and Alinda Vos

Subjects
respiratory complaints, cough, HIV, ART, sub-saharan Africa, Public aspects of medicine, RA1-1270, Infectious and parasitic diseases, RC109-216
Abstract

Background: Chronic respiratory illnesses and respiratory infections are common in HIV-positive populations. It seems reasonable that HIV-positive people experience more respiratory symptoms, such as coughing and breathlessness, than those who are HIV-negative. Objectives: This study aims to determine the frequency of respiratory symptoms in an urban African HIV-positive population. Method: A cross-sectional study was conducted in Johannesburg, South Africa, in 2016–2017. Four groups of participants were included: HIV-positive participants (1) not yet on antiretroviral therapy (ART), (2) on first-line ART, (3) on second-line ART and (4) age- and sex-matched HIV-negative controls. Data were collected on socio-demographics, respiratory risk factors and respiratory symptoms. A logistic regression analysis was performed to determine if respiratory symptoms differed between groups and to identify determinants associated with symptoms. Results: Overall, 547 participants were included, of whom 62% were women, with a median age of 37 years. Of these patients, 63% (347) were HIV-positive, 26% were ART-naïve, 24% were on first-line ART and 50% were on second-line ART. Cough and/or productive cough was reported by 27 (5%), wheezing by 9 (2%) and breathlessness by 118 (22%) of the participants. The frequency of these symptoms did not differ by HIV status after adjustment for age and sex. Breathlessness was associated with age, female sex, obesity, a history of respiratory infection and a history of airway hyper-reactivity. Conclusion: The frequency of respiratory symptoms was low in our study population except for breathlessness. HIV-positive participants, whether or not on ART, did not experience more symptoms than HIV-negative participants.

Published
2019
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3. A Missense Variant in ALDH5A1 Associated with Canine Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) in the Saluki Dog.

Author

Vernau, Karen M, Struys, Eduard, Letko, Anna, Woolard, Kevin D, Aguilar, Miriam, Brown, Emily A, Cissell, Derek D, Dickinson, Peter J, Shelton, G Diane, Broome, Michael R, Gibson, K Michael, Pearl, Phillip L, König, Florian, Van Winkle, Thomas J, O'Brien, Dennis, Roos, B, Matiasek, Kaspar, Jagannathan, Vidhya, Drögemüller, Cord, Mansour, Tamer A, Brown, C Titus, and Bannasch, Danika L

Subjects
4-hydroxybutyric acid, ALDH5A1, GABA, GWAS, SSADHD, encephalopathy, inborn error of metabolism, inherited, precision medicine, succinic semialdehyde, whole-genome sequencing, Genetics
Abstract

Dogs provide highly valuable models of human disease due to the similarity in phenotype presentation and the ease of genetic analysis. Seven Saluki puppies were investigated for neurological abnormalities including seizures and altered behavior. Magnetic resonance imaging showed a diffuse, marked reduction in cerebral cortical thickness, and symmetrical T2 hyperintensity in specific brain regions. Cerebral cortical atrophy with vacuolation (status spongiosus) was noted on necropsy. Genome-wide association study of 7 affected and 28 normal Salukis revealed a genome-wide significantly associated region on CFA 35. Whole-genome sequencing of three confirmed cases from three different litters revealed a homozygous missense variant within the aldehyde dehydrogenase 5 family member A1 (ALDH5A1) gene (XM_014110599.2: c.866G>A; XP_013966074.2: p.(Gly288Asp). ALDH5A1 encodes a succinic semialdehyde dehydrogenase (SSADH) enzyme critical in the gamma-aminobutyric acid neurotransmitter (GABA) metabolic pathway. Metabolic screening of affected dogs showed markedly elevated gamma-hydroxybutyric acid in serum, cerebrospinal fluid (CSF) and brain, and elevated succinate semialdehyde in urine, CSF and brain. SSADH activity in the brain of affected dogs was low. Affected Saluki dogs had striking similarities to SSADH deficiency in humans although hydroxybutyric aciduria was absent in affected dogs. ALDH5A1-related SSADH deficiency in Salukis provides a unique translational large animal model for the development of novel therapeutic strategies.

Published
2020

4. The upper extremity postthrombotic syndrome score: an international Delphi consensus study to determine the score’s functional disability component

Author

Schropp, L., Cats, R.B., de Kleijn, R.J.C.M.F., Black, S., Garcia, D., Meijer, K., Nijziel, M.R., Klappe, E.M., Geroulakos, G., van Ommen, C.H., van Rijn, M.J.E., Freischlag, J., Kruip, M.J.H.A., Huisman, M.V., Coppens, M., Teijink, J.A.W., Kakkos, S.K., Le Gal, G., Westerweel, P.E., Avila, M.L., Kreuziger, L. Baumann, Cate-Hoek, A.J. Ten, Lee, A.Y.Y., Koelemay, M.J., Srivastava, A., Hovens, M.M.C., Ünlü, Ç., Klok, F.A., Douketis, J., Stansby, G., Illig, K.A., Thompson, R.W., Bax, W.A., Poli, D., Kahn, S.R., van Hattum, E.S., Middeldorp, S., Nijkeuter, M., Westerink, J., Petri, B.J., de Borst, G.J., Schropp, Ludo, Cats, Roos B., de Kleijn, Robert J.C.M.F., van Hattum, Eline S., Middeldorp, Saskia, Nijkeuter, Mathilde, Westerink, Jan, Petri, Bart-Jeroen, and de Borst, Gert J.

Published
2023
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8. CrRb: a molecule with large magnetic and electric dipole moments

Author

Pavlovic, Z., Sadeghpour, H. R., Cote, R., and Roos, B. O.

Subjects
Physics - Atomic Physics
Abstract

We report calculations of Born-Oppenheimer potential energy curves of the chromium-rubidium heteronuclear molecule 52Cr-87Rb, and the long-range dispersion coefficient for the interaction between ground state Cr and Rb atoms. Our calculated van der Waals coefficient (C6=1770 a.u.) has an expected error of 3%. The ground state 6Sigma+ molecule at its equilibrium separation has a permanent electric dipole moment of de (Re=3.34 A) = 2.90 D. We investigate the hyperfine and dipolar collisions between trapped Cr and Rb atoms, finding elastic to inelastic cross section ratio of 100-1000.

Published
2010
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12. The upper extremity postthrombotic syndrome score:an international Delphi consensus study to determine the score's functional disability component

Author

Schropp, L., Cats, Roos B., de Kleijn, R. J.C.M.F., van Hattum, Eline S., Middeldorp, Saskia, Nijkeuter, M., Westerink, Jan, Petri, B. J., de Borst, G. J., Schropp, L., Cats, Roos B., de Kleijn, R. J.C.M.F., van Hattum, Eline S., Middeldorp, Saskia, Nijkeuter, M., Westerink, Jan, Petri, B. J., and de Borst, G. J.

Abstract

Background: In upper extremity thrombosis research, the occurrence of upper extremity postthrombotic syndrome (UE-PTS) is commonly used as the main outcome parameter. However, there is currently no reporting standard or a validated method to assess UE-PTS presence and severity. In a recent Delphi study, consensus was reached on a preliminary UE-PTS score, combining 5 symptoms, 3 signs, and the inclusion of a functional disability score. However, no consensus was reached on which functional disability score to be included. Objectives: The aim of the current Delphi consensus study was to determine the specific type of functional disability score to finalize UE-PTS score. Methods: This Delphi project was designed as a three-round study using open text questions, statements with 7-point Likert scales, and multiple-choice questions. The CREDES recommendations for Delphi studies were applied. In this context, a systematic review was conducted before the start of the Delphi rounds to identify the available functional disability scores as available in the literature and present these to the expert panel. Results: Thirty-five of 47 initially invited international experts from multiple disciplines completed all the Delphi rounds. In the second round, consensus was reached on the incorporation of the quick disabilities of the arm, shoulder, and hand (QuickDASH) in the UE-PTS score, rendering the third round obsolete. Conclusion: Consensus was reached that the QuickDASH should be incorporated in the UE-PTS score. The UE-PTS score will need to be validated in a large cohort of patients with upper extremity thrombosis before it can be used in clinical practice and future research.

Published
2023

13. The upper extremity postthrombotic syndrome score: an international Delphi consensus study to determine the score's functional disability component

Author

Ludo Schropp, Roos B. Cats, Robert J.C.M.F. de Kleijn, Eline S. van Hattum, Saskia Middeldorp, Mathilde Nijkeuter, Jan Westerink, Bart-Jeroen Petri, Gert J. de Borst, L. Schropp, R.B. Cats, R.J.C.M.F. de Kleijn, S. Black, D. Garcia, K. Meijer, M.R. Nijziel, E.M. Klappe, G. Geroulakos, C.H. van Ommen, M.J.E. van Rijn, J. Freischlag, M.J.H.A. Kruip, M.V. Huisman, M. Coppens, J.A.W. Teijink, S.K. Kakkos, G. Le Gal, P.E. Westerweel, M.L. Avila, L. Baumann Kreuziger, A.J. Ten Cate-Hoek, A.Y.Y. Lee, M.J. Koelemay, A. Srivastava, M.M.C. Hovens, Ç. Ünlü, F.A. Klok, J. Douketis, G. Stansby, K.A. Illig, R.W. Thompson, W.A. Bax, D. Poli, S.R. Kahn, E.S. van Hattum, S. Middeldorp, M. Nijkeuter, J. Westerink, B.J. Petri, G.J. de Borst, Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Pediatrics, Surgery, Hematology, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, ACS - Amsterdam Cardiovascular Sciences, and ACS - Atherosclerosis & ischemic syndromes

Subjects
All institutes and research themes of the Radboud University Medical Center, upper extremity deep vein thrombosis, diagnosis, Delphi technique, surveys and questionnaires, thoracic outlet syndrome, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], postthrombotic syndrome, Hematology, functional status
Abstract

Contains fulltext : 291124.pdf (Publisher’s version ) (Open Access) BACKGROUND: In upper extremity thrombosis research, the occurrence of upper extremity postthrombotic syndrome (UE-PTS) is commonly used as the main outcome parameter. However, there is currently no reporting standard or a validated method to assess UE-PTS presence and severity. In a recent Delphi study, consensus was reached on a preliminary UE-PTS score, combining 5 symptoms, 3 signs, and the inclusion of a functional disability score. However, no consensus was reached on which functional disability score to be included. OBJECTIVES: The aim of the current Delphi consensus study was to determine the specific type of functional disability score to finalize UE-PTS score. METHODS: This Delphi project was designed as a three-round study using open text questions, statements with 7-point Likert scales, and multiple-choice questions. The CREDES recommendations for Delphi studies were applied. In this context, a systematic review was conducted before the start of the Delphi rounds to identify the available functional disability scores as available in the literature and present these to the expert panel. RESULTS: Thirty-five of 47 initially invited international experts from multiple disciplines completed all the Delphi rounds. In the second round, consensus was reached on the incorporation of the quick disabilities of the arm, shoulder, and hand (QuickDASH) in the UE-PTS score, rendering the third round obsolete. CONCLUSION: Consensus was reached that the QuickDASH should be incorporated in the UE-PTS score. The UE-PTS score will need to be validated in a large cohort of patients with upper extremity thrombosis before it can be used in clinical practice and future research. 01 januari 2023

Published
2023
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27. Erratum: Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Global Health team 1, Unit Opleiding Aios, Kummerow, Maren, Shaddock, Erica J, Klipstein-Grobusch, Kerstin, Barth, Roos B, Grobbee, Diederick E, Francois Venter, W D, Feldman, Charles, Vos, Alinda, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Global Health team 1, Unit Opleiding Aios, Kummerow, Maren, Shaddock, Erica J, Klipstein-Grobusch, Kerstin, Barth, Roos B, Grobbee, Diederick E, Francois Venter, W D, Feldman, Charles, and Vos, Alinda

Published
2021

40. De implementatie van privacywetgeving: het voorspellen van de discrepantie tussen attitude en gedrag van organisaties.:De rol van zichtbaarheid en overheidsafhankelijkheid als voorspellende factoren voor het symbolisch implementeren van privacywetgeving bij het gebruik van tracking in digitale e-mailnieuwsbrieven

Author

de Roos, B. (Bart)

Subjects
decoupling, symbolische implementatie, e-mailtracking, Algemene verordening gegevensbescherming, profilering
Abstract

Dit onderzoek heeft als doel symbolische implementatie van privacywetgeving bij Nederlandse organisaties te bepalen en voorspellen. Vanuit de institutionele theorie en de resource dependence theorie wordt beweerd dat de mate waarin organisaties zichtbaar zijn in gedrukte media en de mate van overheidsafhankelijkheid bepalend zouden kunnen zijn voor de manier waarop organisaties beleid implementeren. Symbolische implementatie wordt in dit onderzoek gemeten door te kijken naar het gebruik van e-mailtracking in e mailnieuwsbrieven van 110 organisaties. Indien deze methode gebruikt wordt, dienen organisaties hiervan melding te maken in het privacy statement. Doen zij dit niet, dan zou er volgens eerdergenoemde theorieën sprake kunnen zijn van decoupling: er is een discrepantie waarneembaar tussen hetgeen een organisatie zegt te doen (attitude) en hetgeen daadwerkelijk doet (gedrag). Daarnaast wordt in dit onderzoek het privacy statement van de onderzochte organisaties getoetst op basis van elf beoordelingspunten die samenhangen met de verplichtingen uit privacywetgeving (waaronder de AVG) omtrent het gebruik van e mailnieuwsbrieven. Dit onderzoek laat zien dat de zichtbaarheid van een organisatie inderdaad de kans op symbolische implementatie of decoupling kan voorspellen. Overheidsafhankelijkheid lijkt niet of minder van invloed, al is opvallend dat bedrijven in de sector overheid of quartaire sector significant slechter scoren op de implementatie van privacywetgeving dan andere sectoren.

Published
2020

42. Expliciet Euphoria en reageerders op Reddit

Author

Roos, B. de, Leurs, Rob (Thesis Advisor), Roos, B. de, and Leurs, Rob (Thesis Advisor)

Abstract

Binnen het genre van tienerdramaseries kan het er qua onderwerpen soms heftig aan toe gaan. Soms worden expliciete elementen als drugs, zelfmoord, mentale ziekten of seks hier nadrukkelijk in beeld gebracht. Dit was bijvoorbeeld het geval in Thirteen Reasons Why dat in 2017 op Netflix verscheen. De manier waarop het thema zelfmoord gepresenteerd werd, zorgde daarbij voor een negatieve controverse in de media. HBO serie Euphoria heeft op het moment van schrijven nog geen controverse opgeroepen terwijl deze serie toch expliciete elementen als drugsgebruik, naakt/seks, geweld en mentale ziekten inzet. Bovendien staat HBO bekend om series met een expliciete inhoud. Zodoende wil ik met dit onderzoek uitzoeken hoe er door kijkers gesproken wordt over expliciete elementen en verhaallijnen in Euphoria. Dit zal ik doen aan de hand van een selectie afgebakende evaluaties van reageerders op het online discussieplatform Reddit. Hierbij zal tevens gekeken worden naar de subreddit als fan-community en hoe de interactie tussen reageerders opgebouwd is. Daarbij zal ik gebruik maken van theorieën van onder andere Mittell, Jenkins, Baym en Stein. Concepten als genres, publiek, identificatie, emoties, (interpretive) fancommunities en personages vormen de leidraad in deze analyse. Na het uitvoeren van een discoursanalyse van reacties op de eerste en laatste aflevering van het eerste seizoen van Euphoria, zal blijken dat bepaalde onderdelen een rol spelen in zowel evaluaties als in de interactie tussen reageerders. Identificatie, emoties, verwachtingen en de rol van personages in de verhaallijnen zijn hier voorbeelden van. Aan de hand van deze onderdelen evalueren reageerders expliciete elementen en verhaallijnen. Tevens illustreert de casus hoe een hechte fan-community in elkaar zit en hoe men daarbinnen met een media-uiting omgaat. Dit onderzoek kan tenslotte laten zien hoe er in de maatschappij (in dit geval specifiek tienerdramaserie-kijkers) gereageerd en omgegaan wordt met heftige

Published
2020

44. Contributors

Author

Abe, C., primary, Accardi, G., additional, Andres-Lacueva, C., additional, Appendino, G., additional, Armentia, A., additional, Arora, R., additional, Azevedo, V., additional, Badole, S.L., additional, Bae, S.-C., additional, Baliga, M.S., additional, Balistreri, C.R., additional, Bermúdez-Humarán, L.G., additional, Bhat, H., additional, Bodhankar, S.L., additional, Bolling, S.F., additional, Bollor, R., additional, Bowden, R.G., additional, Bravo-Clouzet, R., additional, Calder, P.C., additional, Câmara, N.O.S., additional, Candore, G., additional, Castell, M., additional, Castellote, C., additional, Castrodeza, J., additional, Cerón, J.M., additional, Chacko, J., additional, Chowdhury, Z.T., additional, Comalada, M., additional, Contreras-Moreno, J., additional, Cordova, F.M., additional, Correa-Matos, N.J., additional, Crespo, J., additional, de Cienfuegos, G.Á., additional, de Gaetano, G., additional, de Luis, D., additional, de Moreno de LeBlanc, A., additional, de Pablo, M.A., additional, de Roos, B., additional, del Carmen, S., additional, Díaz, L.E., additional, di Giuseppe, R., additional, Donati, M.B., additional, Egger, G., additional, Elias, R.M., additional, Fayad, R., additional, Fazal, F., additional, Feleszko, W., additional, Fischer, A.K., additional, Franch, À., additional, Galena, A.E., additional, Gálvez, J., additional, Gómez-Martínez, S., additional, Graziano, C., additional, Hall, J., additional, Haniadka, R., additional, Hurst, R.D., additional, Hurst, S.M., additional, Iacoviello, L., additional, Inglada, L., additional, Jaffe, R., additional, Jaworska, J., additional, Kaufman, P.B., additional, Khan, N., additional, Kirakosyan, A., additional, Langella, P., additional, Latheef, L., additional, LeBlanc, J.G., additional, Llorach, R., additional, Lucas, E.A., additional, Malhotra, P., additional, Marcos, A., additional, Marín-Casino, M., additional, Martín-Armentia, S., additional, Mateu-de Antonio, J., additional, Menaa, A., additional, Menaa, B., additional, Menaa, F., additional, Mes, J., additional, Minato, K.I., additional, Miyoshi, A., additional, Monagas, M., additional, Moreillon, J., additional, Mullin, G.E., additional, Neyestani, T.R., additional, Oommen, B., additional, Pai, C., additional, Pai, R.J., additional, Pérez-Berezo, T., additional, Pérez-Cano, F.J., additional, Pérez de Heredia, F., additional, Petro, T.M., additional, Pozo-Rubio, T., additional, Prabhala, H.K., additional, Prabhala, R.H., additional, Pravettoni, V., additional, Prescott, S.L., additional, Primavesi, L., additional, Puertollano, E., additional, Puertollano, M.A., additional, Ramos-Romero, S., additional, Rastmanesh, R., additional, Rendina, E., additional, Romeo, J., additional, Sabetisoofyani, A., additional, Sampath, P., additional, Schauss, A.G., additional, Seymour, E.M., additional, Sharma, A., additional, Shelmadine, B., additional, Smith, B.J., additional, Somasundaram, S.G., additional, Sung, M.-K., additional, Togni, S., additional, Urpi-sarda, M., additional, Vaghefi, S.B., additional, Watson, R.R., additional, Weber, C.E., additional, West, C.E., additional, Wichers, H., additional, Wood, L.G., additional, Xaus, J., additional, Yashawanth, H.S., additional, and Zibadi, S., additional

Published
2013
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