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The ongoing technological development leads to the emergence of a new value-creation paradigm that calls for changes and structural transformations in economic systems at different levels. Structural transformations are prompted by growing economic complexity. In this context, the selection of industrial strategies and the validation of key regional industrial policies is of paramount importance. Economic complexity (EC) analysis is a new effective tool to address the issue. Its application at a subnational level is, however, limited by methodological problems. To analyse economic complexity at a subnational level, a basic methodology and special software were developed within this study. The object of the research is the exclave Kaliningrad region, whose location makes it possible to capture accurate and comprehensive data on international and interregional trade. Based on the EC analysis theory and practice, the study involved the development of methods, algorithms, and software to form a source database and measure economic complexity. The findings may guide the use of EC analyses in regional policies. The article suggests activities for sequential upgrading of the industry in the Kaliningrad region. These activities will facilitate the development of the existing and new capabilities, improve the business environment, and increase the complexity of products, productions, and industries.

Abstract Music is a promising (adjunctive) treatment for both acute and chronic pain, reducing the need for pharmacological analgesics and their side effects. Yet, little is known about the effect of different types of music. Hence, we investigated the efficacy of five music genres (Urban, Electronic, Classical, Rock and Pop) on pain tolerance. In this parallel randomized experimental study, we conducted a cold pressor test in healthy volunteers (n = 548). The primary outcome was pain tolerance, measured in seconds. No objective (tolerance time) or subjective (pain intensity and unpleasantness) differences were found among the five genres. Multinomial logistic regression showed that overall genre preference positively influenced pain tolerance. In contrast, the music genres that participants thought would help for pain relief did not. Our study was the first to investigate pain tolerance at genre level and in the context of genre preference without self-selecting music. In conclusion, this study provides evidence that listening to a favored music genre has a significant positive influence on pain tolerance, irrespective of the kind of genre. Our results emphasize the importance of individual music (genre) preference when looking at the analgesic benefits of music. This should be considered when implementing music in the clinical setting.

This study investigates whether inequalities in the utilization of resection and/or ablation for synchronous colorectal liver metastases (SCLM) between patients diagnosed in expert and non-expert hospitals changed since a multi-hospital network started. Patients diagnosed with SCLM between 2009 and 2020 were included. The likelihood of receiving ablation and/or resection was analyzed in the prenetwork (2009–2012), startup (2013–2016), and matured-network (2017–2020) periods. Nationwide, 13.981patients were diagnosed between 2009 and 2020, of whom 1.624 were diagnosed in the network. Of patients diagnosed in the network's expert hospitals, 36.7% received ablation and/or resection versus 28.3% in nonexpert hospitals (p < 0.01). The odds ratio (OR) of receiving ablation and/or resection for patients diagnosed in expert versus nonexpert hospitals increased from 1.38 (p = 0.581, pre-network), to 1.66 (p = 0.108, startup), to 2.48 (p = 0.090, matured-network). Nationwide, the same trend occurred (respectively OR 1.41, p = 0.011; OR 2.23, p < 0.001; OR 3.20, p < 0.001). Patients diagnosed in expert hospitals were more likely to receive ablation and/or resection for SCLM than patients diagnosed in non-expert hospitals. This difference increased over time despite the startup of a multi-hospital network. Establishing a multi-hospital network did not have an effect on reducing the existing unequal odds of receiving specialized treatment. Specialized oncology treatments are increasingly provided through multi-hospital networks. However, scant empirical evidence on the effectiveness of these networks exists. This study analyzes whether a regional multi-hospital network was able to improve equal access to specialized oncology treatments. [ABSTRACT FROM AUTHOR]

A DFT study on the reactivity of an alkoxide and a thiolate toward the neutral and all ionic forms of arsenate and phosphate is presented. The reactions of these experiments are explained in the study.

Summary: Postbariatric outcomes may improve by providing an additional preconditioning program (APP) in targeted patients. However, APPs are a demand for health resources while only little and inconsistent evidence consists to support their effectiveness. This cohort study aims to evaluate the effectiveness of APP, by comparing outcomes of patients with and without such APP. We carried out a retrospective single‐centre cohort study in a before‐after design. Patients signing up for primary gastric bypass or sleeve gastrectomy and eligible for surgery were included if screened as vulnerable patients. Vulnerable patients screened between September 2017 and March 2018 followed an APP and formed the APP‐group. Due to a policy change, APPs were no longer performed since September 2018. Vulnerable patients screened between September 2018 and March 2019 thus did not receive an APP (comparator‐group). Multidisciplinary follow‐up remained unchanged. Endpoints included percentage total weight loss (%TWL), bodyweight, evolution of comorbidities, protein intake, and number of no‐shows. The APP‐group comprised 231 patients and the comparator‐group 153. %TWL differed statistically significantly at 7 (Δ1.5%, p =.01) and 12 months postoperative (Δ2.8%, p <.01) in favour of the comparator‐group, as did bodyweight 12 months postoperative (Δ1.8 kg, p <.01). Statistically significant differences were also found in the evolution of comorbidities, protein intake, and the number of no‐shows, most in favour for the comparator‐group. APP proofed not to be superior to Non‐App. It is debatable whether statically significant differences are clinically relevant given their small magnitude. A care pathway without an APP seems at least as effective as a care pathway without. [ABSTRACT FROM AUTHOR]