Search

Your search keyword '"Roosnek, Eddy"' showing total 363 results
Start Over Author "Roosnek, Eddy"
363 results on '"Roosnek, Eddy"'

1. Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation

Author

Achermann, Rita, Aubert, John-David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Berger, Christoph, Binet, Isabelle, Bochud, Pierre-Yves, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Gasche, Yvan, Soccal, Paola Gasche, Giostra, Emiliano, Golshayan, Déla, Good, Daniel, Hadaya, Karine, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Klaghofer, Richard, Koller, Michael, Kuntzen, Thomas, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans-Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J., Mueller-McKenna, Helen, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Nair, Gayathri, Pascual, Manuel, Passweg, Jakob, Piot Ziegler, Chantal, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Seiler, Christian, Semmo, Nasser, Stampf, Susanne, Steiger, Jürg, Toso, Christian, Tsinalis, Dimitri, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick, Wójtowicz, Agnieszka, Bibert, Stéphanie, Pyndiah, Nitisha, Buhler, Leo H., and Mueller, Thomas

Published
2016
Full Text
View/download PDF

3. Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study

Author

Beckmann, Sonja, Nikolic, Nataša, Denhaerynck, Kris, Binet, Isabelle, Koller, Michael, Boely, Elsa, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Claes, Veerle, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Mauthner, Oliver, Struker, Marian, Boehler, Annette, Gerull, Sabine, Huynh‐Do, Uyen, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Chalandon, Yves, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
Full Text
View/download PDF

4. BK Polyomavirus‐Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study

Author

Leboeuf, C., Wilk, S., Achermann, R., Binet, I., Golshayan, D., Hadaya, K., Hirzel, C., Hoffmann, M., Huynh‐Do, U., Koller, M. T., Manuel, O., Mueller, N. J., Mueller, T. F., Schaub, S., van Delden, C., Weissbach, F. H., Hirsch, H. H., Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
Full Text
View/download PDF

6. ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study

Author

Mauthner, Oliver, Claes, Veerle, Walston, Jeremy, Engberg, Sandra, Binet, Isabelle, Dickenmann, Michael, Golshayan, Déla, Hadaya, Karine, Huynh‐Do, Uyen, Calciolari, Stefano, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Denhaerynck, Kris, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Struker, Marian, Boehler, Annette, Gerull, Sabine, Koller, Michael T, Boely, Elsa, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Beckmann, Sonja, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Rougemont, Olivier, Duchosal, Michel, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Koller, Michael, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Martinolli, Luca, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Ziegler, Chantal Piot, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
Full Text
View/download PDF

7. Expansion of Phenotypically Senescent CD57+ CD8 T Cells Is Associated with Impaired Immunocompetence after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Morin, Sarah, primary, Pradier, Amandine, additional, Giannotti, Federica, additional, Mamez, Anne-Claire, additional, Vu-Cantero, Diem-Lan, additional, Fabra-Urdiola, Marta, additional, Stephan, Caroline, additional, Bernardi, Chiara, additional, Melotti, Astrid, additional, Masouridi-Levrat, Stavroula, additional, Roosnek, Eddy, additional, Kaiser, Laurent, additional, Chalandon, Yves, additional, and Simonetta, Federico, additional

Published
2021
Full Text
View/download PDF

9. APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

Author

Huard, Bertrand, McKee, Thomas, Bosshard, Carine, Durual, Stephane, Matthes, Thomas, Myit, Samir, Donze, Olivier, Frossard, Christophe, Chizzolini, Carlo, Favre, Christiane, Zubler, Rudolf, Guyot, Jean Philippe, Schneider, Pascal, and Roosnek, Eddy

Subjects
Control, Physiological aspects, Usage, Research, Cell proliferation -- Physiological aspects -- Control -- Research -- Usage, Polymerase chain reaction -- Usage -- Physiological aspects -- Research, Neutrophils -- Physiological aspects -- Research -- Usage
Abstract

Introduction B cells encountering antigen in the T cell zone of secondary lymphoid organs migrate into primary follicles to divide extensively. After this initial proliferation, B cells have to process [...], The bone marrow constitutes a favorable environment for long-lived antibody-secreting plasma cells, providing blood-circulating antibody. Plasma cells are also present in mucosa-associated lymphoid tissue (MALT) to mediate local frontline immunity, but how plasma cell survival there is regulated is not known. Here we report that a proliferation-inducing ligand (APRIL) promoted survival of human upper and lower MALT plasma cells by upregulating expression of the antiapoptotic proteins bcl-2, bcl-[x.sub.L], and mcl-1. The in situ localization of APRIL was consistent with such a prosurvival role in MALT. In upper MALT, tonsillar epithelium produced APRIL. Upon infection, APRIL production increased considerably when APRIL-secreting neutrophils recruited from the blood infiltrated the crypt epithelium. Heparan sulfate proteoglycans (HSPGs) retained secreted APRIL in the subepithelium of the infected zone to create APRIL-rich niches, wherein IgG-producing plasma cells accumulated. In lower MALT, neutrophils were the unique source of APRIL, giving rise to similar niches for IgA-producing plasmocytes in villi of lamina propria. Furthermore, we found that mucosal humoral immunity in APRIL-deficient mice is less persistent than in WT mice. Hence, production of APRIL by inflammation-recruited neutrophils may create plasma cell niches in MALT to sustain a local antibody production.

Published
2008

10. First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Author

Tschopp, Jonathan, LHuillier, Arnaud G., Mombelli, Matteo, Mueller, Nicolas J., Khanna, Nina, Garzoni, Christian, Meloni, Dario, Papadimitriou‐Olivgeris, Matthaios, Neofytos, Dionysios, Hirsch, Hans H., Schuurmans, Macé M., Müller, Thomas, Berney, Thierry, Steiger, Jürg, Pascual, Manuel, Manuel, Oriol, Delden, Christian, Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Binet, Isabelle, Bochud, Pierre‐Yves, Branca, Sanda, Bucher, Heiner, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, Geest, Sabina, Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Hauri, Dimitri, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H, Hofbauer, Günther, Huynh‐Do, Uyen, Immer, Franz, Klaghofer, Richard, Koller, Michael, Laesser, Bettina, Laube, Guido, Lehmann, Roger, Lovis, Christian, Majno, Pietro, Marti, Hans‐Peter, Martin, Pierre Yves, Martinelli, Michele, Meylan, Pascal, Mueller, Nicolas J, Müller, Antonia, Müllhaupt, Beat, Passweg, Jakob, Posfay‐Barbe, Klara, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Schuurmans, Macé, Seiler, Christian, Sprachta, Jan, Stampf, Susanne, Steinack, Carolin, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick, University of Zurich, Swiss Transplant Cohort Study (STCS), Amico, P., Aubert, J.D., Banz, V., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Branca, S., Bucher, H., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Elkrief, L., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Soccal, P.G., Gaudet, C., Giostra, E., Golshayan, D., Hadaya, K., Halter, J., Hauri, D., Heim, D., Hess, C., Hillinger, S., Hirsch, H.H., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Laesser, B., Laube, G., Lehmann, R., Lovis, C., Majno, P., Manuel, O., Marti, H.P., Martin, P.Y., Martinelli, M., Meylan, P., Mueller, N.J., Müller, A., Müller, T., Müllhaupt, B., Pascual, M., Passweg, J., Posfay-Barbe, K., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Schuurmans, M., Seiler, C., Sprachta, J., Stampf, S., Steinack, C., Steiger, J., Stirnimann, G., Toso, C., Van Delden, C., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., and Yerly, P.

Subjects
Male, 10255 Clinic for Thoracic Surgery, Comorbidity, 030230 surgery, Infection and infectious agents/ Viral, Organ transplantation, 10234 Clinic for Infectious Diseases, 0302 clinical medicine, Postoperative Complications, Epidemiology, Immunology and Allergy, Medicine, Pharmacology (medical), Prospective Studies, Prospective cohort study, ddc:616, Infectious disease, education.field_of_study, ddc:618, ddc:617, Incidence, Clinical research/ practice, Middle Aged, 3. Good health, Survival Rate, 10209 Clinic for Cardiology, Female, medicine.symptom, 10178 Clinic for Pneumology, Coronavirus Infections, infectious [Complication], infectious, infection and infectious agents, infection and infectious agents - viral, infectious disease [Aged, Betacoronavirus, Coronavirus Infections/epidemiology, Disease Transmission, Infectious/prevention & control, Follow-Up Studies, Humans, Organ Transplantation/methods, Pandemics, Pneumonia, Viral/epidemiology, Postoperative Complications/epidemiology, Survival Rate/trends, Switzerland/epidemiology, Transplant Recipients, clinical research/ practice, complication], Switzerland, Cohort study, medicine.medical_specialty, Nausea, Population, Pneumonia, Viral, Infection and infectious agents, 610 Medicine & health, Brief Communication, 03 medical and health sciences, Internal medicine, Disease Transmission, Infectious, education, Survival rate, Aged, Transplantation, business.industry, SARS-CoV-2, COVID-19, Organ Transplantation, medicine.disease, 10032 Clinic for Oncology and Hematology, business
Abstract

Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, comprehensive data of SARS‐CoV‐2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS‐CoV‐2 infection among SOT recipients. Overall, 21 patients were included with a median age of 56 years (10 kidney, 5 liver, 1 pancreas, 1 lung, 1 heart and 3 combined transplantations). The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%) and diarrhea (33%). Ninety‐five percent and 24% of patients required hospital and ICU admission, respectively, and 19% were intubated. After a median of 33 days of follow‐up, 16 patients were discharged, 3 were still hospitalized and 2 patients died. These data suggest that clinical manifestations of SARS‐CoV‐2 infection in middle‐aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. These results need to be confirmed in larger cohorts.

Published
2020

16. Torque Teno Virus as a Potential Biomarker for Complications and Survival After Allogeneic Hematopoietic Stem Cell Transplantation

Author

Pradier, Amandine, primary, Masouridi-Levrat, Stavroula, additional, Bosshard, Carine, additional, Dantin, Carole, additional, Vu, Diem-Lan, additional, Zanella, Marie-Céline, additional, Boely, Elsa, additional, Tapparel, Caroline, additional, Kaiser, Laurent, additional, Chalandon, Yves, additional, Simonetta, Federico, additional, and Roosnek, Eddy, additional

Published
2020
Full Text
View/download PDF

18. Management of allergy transfer upon solid organ transplantation

Author

Muller, Yannick D, Vionnet, Julien, Beyeler, Franziska, Eigenmann, Philippe, Caubet, Jean-Christoph, Villard, Jean, Berney, Thierry, Scherer, Kathrin, Spertini, Francois, Fricker, Michael P, Lang, Claudia, Schmid-Grendelmeier, Peter, Benden, Christian, Lombard, Pascale Roux, Aubert, Vincent, Immer, Franz, Pascual, Manuel, Harr, Thomas, Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beldi, Guido, Berger, Christoph, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Golshayan, Dela, Hadaya, Karine, Halter, Joerg, Hauri, Dimitri, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H, Hofbauer, Guenther, Huynh-Do, Uyen, Klaghofer, Richard, Koller, Michael, Laesser, Bettina, Laube, Guido, Lehmann, Roger, Lovis, Christian, Majno, Pietro, Manuel, Oriol, Marti, Hans-Peter, Martin, Pierre Yves, Martinelli, Michele, Meylan, Pascal, Morel, Philippe, Mueller, Nicolas J, Mueller, Antonia, Mueller, Thomas, Muellhaupt, Beat, Yerly, Patrick, Passweg, Jakob, Posfay-Barbe, Klara, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Sprachta, Jan, Stampf, Susanne, Steiger, Juerg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean-Pierre, Wick, Madeleine, Wilhelm, Markus, Swiss Transplant Cohort Study, Amico, P., Aubert, J.D., Banz, V., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Branca, S., Bucher, H., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Elkrief, L., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Gasche Soccal, P., Gaudet, C., Giostra, E., Golshayan, D., Hadaya, K., Halter, J., Hauri, D., Heim, D., Hess, C., Hillinger, S., Hirsch, H.H., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Laesser, B., Laube, G., Lehmann, R., Lovis, C., Majno, P., Manuel, O., Marti, H.P., Yves Martin, P., Martinelli, M., Meylan, P., Morel, P., Mueller, N.J., Müller, A., Müller, T., Müllhaupt, B., Pascual, M., Passweg, J., Posfay-Barbe, K., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Seiler, C., Sprachta, J., Stampf, S., Steiger, J., Stirnimann, G., Toso, C., Van Delden, C., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, Muller, Yannick D, Gasche-Soccal, Paola Marina Alessandra, Posfay Barbe, Klara, and Lovis, Christian

Subjects
Allergy, diagnostic techniques and imaging, IgE, Immunoglobulin E, allergy transfer, anaphylaxis, immunosuppression, management, solid organ transplantation, allergy, business/management, clinical decision-making, clinical research/practice, guidelines, immunoglobulin E, immunosuppression/immune modulation, organ transplantation in general, patient safety, 10255 Clinic for Thoracic Surgery, 2747 Transplantation, medicine.medical_treatment, 030230 surgery, INCREASE, Cohort Studies, 0302 clinical medicine, Solid organ transplantation, Immunology and Allergy, Medicine, 2736 Pharmacology (medical), Pharmacology (medical), LUNG TRANSPLANTATION, ddc:616, Kidney, ddc:618, biology, ddc:617, PEANUT ALLERGY, 10177 Dermatology Clinic, Immunosuppression, practice, Management, clinical decision‐making, medicine.anatomical_structure, B-CELLS, 10209 Clinic for Cardiology, 2723 Immunology and Allergy, 10178 Clinic for Pneumology, Brief Communications, Life Sciences & Biomedicine, Anaphylaxis, medicine.medical_specialty, 610 Medicine & health, Brief Communication, 03 medical and health sciences, Internal medicine, Humans, Peanut Hypersensitivity, Allergy transfer, business, Retrospective Studies, Transplantation, Lung, Science & Technology, immune modulation, business.industry, Organ Transplantation, medicine.disease, clinical research, 10036 Medical Clinic, 10032 Clinic for Oncology and Hematology, biology.protein, ASTHMA, Surgery, IMMUNOGLOBULIN-E
Abstract

Allergy transfer upon solid organ transplantation has been reported in the literature, although only few data are available as to the frequency, significance, and management of these cases. Based on a review of 577 consecutive deceased donors from the Swisstransplant Donor‐Registry, 3 cases (0.5%) of fatal anaphylaxis were identified, 2 because of peanut and 1 of wasp allergy. The sera of all 3 donors and their 10 paired recipients, prospectively collected before and after transplantation for the Swiss Transplant Cohort Study, were retrospectively processed using a commercial protein microarray fluorescent test. As early as 5 days posttransplantation, newly acquired peanut‐specific IgE were transiently detected from 1 donor to 3 recipients, of whom 1 liver and lung recipients developed grade III anaphylaxis. Yet, to define how allergy testing should be performed in transplant recipients and to better understand the impact of immunosuppressive therapy on IgE sensitization, we prospectively studied 5 atopic living‐donor kidney recipients. All pollen‐specific IgE and >90% of skin prick tests remained positive 7 days and 3 months after transplantation, indicating that early diagnosis of donor‐derived IgE sensitization is possible. Importantly, we propose recommendations with respect to safety for recipients undergoing solid‐organ transplantation from donors with a history of fatal anaphylaxis., Based on the Swisstransplant donor registry, the Swiss‐Transplant‐Cohort‐Study, and a prospective analysis on allergy maintenance in atopic recipients, this study makes new recommendations for the management of allergy transfer upon solid organ transplantation, emphasizing the poor effect of immunosuppression on IgE sensitization and the need of early allergological investigation in the donor and respective recipients.

Published
2020

28. Torque Teno Virus Load and Acute Rejection After Orthotopic Liver Transplantation

Author

Simonetta, Federico, Pradier, Amandine, Masouridi-Levrat, Stavroula, Van Delden, Christian, Giostra, Emiliano, Morard, Isabelle, Mueller, Nicolas, Muellhaupt, Beat, Valli, Piero V, Semmo, Nasser, Seebach, Jörg, Chalandon, Yves, Kaiser, Laurent, Roosnek, Eddy, Banz Wüthrich, Vanessa, Beldi, Guido, Stirnimann, Guido, Huynh-Do, Uyen, and Swiss Transplant Cohort Study, (STCS)

Subjects
Adult, Graft Rejection, Male, Torque teno virus, Adolescent, Orthotopic liver transplantation, medicine.medical_treatment, 610 Medicine & health, 030230 surgery, Liver transplantation, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Dna viral, Child, Aged, ddc:616, Transplantation, ddc:617, Graft rejection, business.industry, Infant, Middle Aged, Viral Load, Virology, Liver Transplantation, Child, Preschool, DNA, Viral, Female, 030211 gastroenterology & hepatology, business, Viral load
Published
2017
Full Text
View/download PDF

37. Reply to Cunha et al

Author

Wójtowicz, Agnieszka, Lecompte, Thanh Doco, Bibert, Stéphanie, Manuel, Oriol, Rüeger, Sina, Berger, Christoph, Boggian, Katia, Cusini, Alexia, Garzoni, Christian, Khanna, Nina, Mueller, Nicolas J., Meylan, Pascal R., Pascual, Manuel, van Delden, Christian, Bochud, Pierre-Yves, Achermann, Rita, Aubert, John-David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Binet, Isabelle, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Gasche, Yvan, Soccal, Paola Gasche, Giostra, Emiliano, Golshayan, Déla, Good, Daniel, Hadaya, Karine, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Klaghofer, Richard, Koller, Michael, Kuntzen, Thomas, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans-Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller-McKenna, Helen, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Nair, Gayathri, Passweg, Jakob, Ziegler, Chantal Piot, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Seiler, Christian, Semmo, Nasser, Stampf, Susanne, Steiger, Jürg, Toso, Christian, Tsinalis, Dimitri, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017

38. BAFF production by antigen‐presenting cells provides T cell co‐stimulation

Author

Huard, Bertrand, Arlettaz, Lionel, Ambrose, Christine, Kindler, Vincent, Mauri, Davide, Roosnek, Eddy, Tschopp, Jürg, Schneider, Pascal, and French, Lars E.

Subjects
stomatognathic diseases, stomatognathic system, immune system diseases, hemic and lymphatic diseases, skin and connective tissue diseases
Abstract

The B cell‐activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co‐stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co‐stimulatory function. BAFF is produced by antigen‐presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34+ stem cells express BAFF mRNA. Exposure to bacterial products further up‐regulates BAFF production in these cells. A low level of BAFF transcription, up‐regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC

Published
2017

39. PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Author

Wójtowicz, Agnieszka, Lecompte, T. Doco, Bibert, Stephanie, Manuel, Oriol, Rüeger, Sina, Berger, Christoph, Boggian, Katia, Cusini, Alexia, Garzoni, Christian, Hirsch, Hans, Khanna, Nina, Mueller, Nicolas J., Meylan, Pascal R., Pascual, Manuel, van Delden, Christian, Bochud, Pierre-Yves, Achermann, Rita, Aubert, John-David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Binet, Isabelle, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Gasche, Yvan, Soccal, Paola Gasche, Giostra, Emiliano, Golshayan, Déla, Good, Daniel, Hadaya, Karine, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Klaghofer, Richard, Koller, Michael, Kuntzen, Thomas, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans-Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller-McKenna, Helen, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Nair, Gayathri, Passweg, Jakob, Ziegler, Chantal Piot, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Seiler, Christian, Semmo, Nasser, Stampf, Susanne, Steiger, Jürg, Toso, Christian, Tsinalis, Dimitri, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Abstract

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification

Published
2017

41. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

Author

Storek, Jan, Geddes, Michelle, Khan, Faisal, Huard, Bertrand, Helg, Claudine, Chalandon, Yves, Passweg, Jakob, Roosnek, Eddy, Storek, Jan, Geddes, Michelle, Khan, Faisal, Huard, Bertrand, Helg, Claudine, Chalandon, Yves, Passweg, Jakob, and Roosnek, Eddy

Abstract

Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery

Published
2018

42. Partial T-cell depletion improves the composite endpoint graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic stem cell transplantation

Author

Simonetta, Federico, primary, Masouridi-Levrat, Stavroula, additional, Beauverd, Yan, additional, Tsopra, Olga, additional, Tirefort, Yordanka, additional, Koutsi, Aikaterini, additional, Stephan, Caroline, additional, Polchlopek-Blasiak, Karolina, additional, Pradier, Amandine, additional, Dantin, Carole, additional, Ansari, Marc, additional, Roosnek, Eddy, additional, and Chalandon, Yves, additional

Published
2017
Full Text
View/download PDF

44. Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients

Author

Mohty Bilal, Bel Michael, Vukicevic Marija, Nagy Monika, Levrat Emmanuel, Meier Sara, Grillet Stephane, Combescure Christophe, Kaiser Laurent, Chalandon Yves, Passweg Jakob, Siegrist Claire-Anne, Roosnek Eddy, Blood and Marrow Transplant Program, Geneva University Hospitals H1N1 study group, Mohty, Bilal, Bel, Michael, Vukicevic Verhille, Marija, Nagy, Monika, Levrat, Emmanuel, Meier, Sara, Grillet, Stéphane, Combescure, Christophe, Kaiser, Laurent, Chalandon, Yves, Passweg, Jakob, Siegrist, Claire-Anne, Roosnek, Eddy Emile, Posfay Barbe, Klara, Sealy, Gregg, Charvat-Jackson, Sandrine, Desmeules, Jules Alexandre, Verdon, Mélanie, Hirschel, Bernard, Calmy, Alexandra, Nguyen, Alexandra, Delhumeau-Cartier, Cécile, Ambrosini, Joëlle, Gabay, Cem, Guerne, Pierre-André, Seebach, Jorg Dieter, Ribi, Camillo, Villard, Jean, Dietrich, Pierre-Yves, George, Anne-Claude Catherine, Favet, Laurence, Van Delden, Christian, Morard, Isabelle, Mentha, Gilles, Giostra, Emiliano, Hadaya, Karine, Martin, Pierre-Yves, Gasche-Soccal, Paola Marina Alessandra, Berney, Thierry, Noble, Stéphane Laurent, Yerly Ferrillo, Sabine, Thomas, Yves, and Wunderli, Werner

Subjects
Male, Antibody Formation/immunology, medicine.medical_treatment, Graft vs Host Disease, Hematopoietic stem cell transplantation, ddc:616.07, Antibodies, Viral, 0302 clinical medicine, Medicine, ddc:616, ddc:618, ddc:617, Hematopoietic Stem Cell Transplantation, virus diseases, Hematology, Middle Aged, 3. Good health, Vaccination, Influenza Vaccines/adverse effects/immunology, Influenza Vaccines, 030220 oncology & carcinogenesis, Female, Graft vs Host Disease/immunology, Stem cell, Adult, 03 medical and health sciences, Immunocompromised Host, Transplantation, Homologous/immunology, Young Adult, Immune system, Immunity, Transplantation, Homologous, Humans, AS03, Hematopoietic Stem Cell Transplantation/adverse effects, Aged, Antibodies, Viral/blood/immunology, Immunity, Humoral/immunology, business.industry, Original Articles, medicine.disease, Virology, Immunity, Humoral, Transplantation, Graft-versus-host disease, Immunology, Antibody Formation, Immunization, business, 030215 immunology
Abstract

BACKGROUND Responses to influenza vaccines are poorly characterized in immunocompromised patients. The goal of this study was to assess the efficacy of the AS03 adjuvanted influenza H1N1/A/09 vaccine in allogeneic hematopoietic stem cell transplant recipients. DESIGN AND METHODS We enrolled 65 patients and 138 controls in an open prospective study. Controls received one dose and patients 2 doses of the AS03 adjuvanted influenza H1N1/A/09 vaccine at a 3 week interval. Geometric mean titers and seroprotection/seroconversion rates were determined by hemagglutination inhibition before and four weeks after the last immunization. Clinical and biological markers including immunoglobulins CD3+ CD4+ CD8+ and naïve CD4+ T cell counts were assessed in all patients. RESULTS Baseline seroprotection rates were low in patients (6.6) and controls (14.8). After 2 doses patients (n=57 92.3) achieved similar seroprotection rates (84 vs. 87 P=0.65) and antibody titers (305 vs. 340 P=0.88) as controls (n=131 93.9) after one dose. In univariate analysis transplant to vaccination interval less than 12 months active graft versus host disease immunosuppressive drugs hemoglobin less than 12 g/L lymphopenia less than 1 G/L IgG less than 4 g/L IgA less than 0.5 g/L IgM less than 0.5 g/L and naive CD4+ T cells less than 150/µL were significantly associated with weaker responses. Multivariate analysis identified transplant to vaccination interval and active graft versus host disease as the most powerful negative predictors of antibody responses (P=0.04 and P=0.002 respectively). Vaccination was well tolerated in both cohorts. CONCLUSIONS In allogeneic hematopoietic stem cell transplant recipients 2 doses of an adjuvanted influenza vaccine elicited comparable responses to a single dose in healthy individuals. However vaccine responses remained poor in patients with ongoing graft versus host disease supporting the need for additional strategies in this high risk patient population. (ClinicalTrials.gov Identifier: NCT01022905).

Published
2011

45. Efficient Prophylaxis with Defibrotide for Sinusoidal Obstruction Syndrome (SOS) after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Author

Chalandon, Yves, primary, Simonetta, Federico, additional, Dantin, Carole, additional, Koutsi, Aikaterini, additional, Mamez, Anne-Claire, additional, Beauverd, Yan, additional, Tsopra, Olga, additional, Simon, Audrey, additional, Bex, Stijn, additional, Stephan, Caroline, additional, Rodriguez Morales, Juan Felipe, additional, Polchlopek, Karolina, additional, Ansari, Marc, additional, Tirefort, Yordanka, additional, Roosnek, Eddy, additional, and Masouridi-Levrat, Stavroula, additional

Published
2016
Full Text
View/download PDF

49. Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation

Author

Golshayan, Déla, primary, Wójtowicz, Agnieszka, additional, Bibert, Stéphanie, additional, Pyndiah, Nitisha, additional, Manuel, Oriol, additional, Binet, Isabelle, additional, Buhler, Leo H., additional, Huynh-Do, Uyen, additional, Mueller, Thomas, additional, Steiger, Jürg, additional, Pascual, Manuel, additional, Meylan, Pascal, additional, Bochud, Pierre-Yves, additional, Achermann, Rita, additional, Aubert, John-David, additional, Baumann, Philippe, additional, Beldi, Guido, additional, Benden, Christian, additional, Berger, Christoph, additional, Boely, Elsa, additional, Bucher, Heiner, additional, Bühler, Leo, additional, Carell, Thierry, additional, Catana, Emmanuelle, additional, Chalandon, Yves, additional, de Geest, Sabina, additional, de Rougemont, Olivier, additional, Dickenmann, Michael, additional, Duchosal, Michel, additional, Fehr, Thomas, additional, Ferrari-Lacraz, Sylvie, additional, Garzoni, Christian, additional, Gasche, Yvan, additional, Soccal, Paola Gasche, additional, Giostra, Emiliano, additional, Golshayan, Déla, additional, Good, Daniel, additional, Hadaya, Karine, additional, Hess, Christoph, additional, Hillinger, Sven, additional, Hirsch, Hans H., additional, Hofbauer, Günther, additional, Immer, Franz, additional, Klaghofer, Richard, additional, Koller, Michael, additional, Kuntzen, Thomas, additional, Laesser, Bettina, additional, Lehmann, Roger, additional, Lovis, Christian, additional, Marti, Hans-Peter, additional, Martin, Pierre Yves, additional, Mohacsi, Paul, additional, Morard, Isabelle, additional, Morel, Philippe, additional, Mueller, Ulrike, additional, Mueller, Nicolas J., additional, Mueller-McKenna, Helen, additional, Müller, Thomas, additional, Müllhaupt, Beat, additional, Nadal, David, additional, Nair, Gayathri, additional, Passweg, Jakob, additional, Piot Ziegler, Chantal, additional, Rick, Juliane, additional, Roosnek, Eddy, additional, Rosselet, Anne, additional, Rothlin, Silvia, additional, Ruschitzka, Frank, additional, Schanz, Urs, additional, Schaub, Stefan, additional, Seiler, Christian, additional, Semmo, Nasser, additional, Stampf, Susanne, additional, Toso, Christian, additional, Tsinalis, Dimitri, additional, Van Delden, Christian, additional, Venetz, Jean-Pierre, additional, Villard, Jean, additional, Wick, Madeleine, additional, Wilhelm, Markus, additional, and Yerly, Patrick, additional

Published
2016
Full Text
View/download PDF

50. T-Cell Depletion Improves the Composite End Point Graft-Versus-Host Disease-Free, Relapse-Free Survival after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Simonetta, Federico, primary, Masouridi-Levrat, Stavroula, additional, Beauverd, Yan, additional, Tsopra, Olga, additional, Tirefort, Yordanka, additional, Stephan, Caroline, additional, Polchlopek, Karolina, additional, Favale, Riccardo, additional, Dantin, Carole, additional, Ansari, Marc, additional, Roosnek, Eddy, additional, and Chalandon, Yves, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results