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2. Are pediatricians familiar with hereditary angioedema?

Author

Chong-Neto, Herberto José, Aroni, Bárbara Padilha, Mansour, Eli, Toledo, Eliana, Serpa, Faradiba Sarquis, Arruda, Luisa Karla, Giavina-Bianchi, Pedro, Valle, Solange Oliveira Rodrigues, de Moraes, Caroline Guth de Freitas Batista, Kruk, Tatielly, Chong-Silva, Débora Carla, Solé, Dirceu, Silva, Luciana Rodrigues, Grumach, Anete S., Rosário Filho, Nelson Augusto, and Campos, Régis de Albuquerque

Published
2023
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3. Latin American anaphylaxis registry

Author

Jares, Edgardo J., Cardona, Victoria, Gómez, R. Maximiliano, Bernstein, Jonathan A., Rosario Filho, Nelson A., Cherrez-Ojeda, Ivan, Ensina, Luis Felipe, De Falco, Alicia, Díaz, María C., Chávez Vereau, Pierre A., Rocha Felix, Mara M., Lavrut, Jorge, Moreno Laflor, Oscar I., Latour Staffeld, Patricia, Piraino, Pedro, Alacaraz Duarte, Perla, Ivancevich, Juan C., Dabove, Fabian, Giavina-Bianchi, Pedro, Tinoco Moran, Iván O., Nunes Oliviera, Fabiana A., Monsell, Silvana, Souza, María V., Cepeda, Alfonso M., Slullitel, Pablo D., and Morfin-Maciel, Blanca M.

Published
2023
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5. Allergic manifestations of inborn errors of immunity and their impact on the diagnosis: A worldwide study

Author

El-Sayed, Zeinab A., El-Ghoneimy, Dalia H., Ortega-Martell, José A., Radwan, Nesrine, Aldave, Juan C., Al-Herz, Waleed, Al-Nesf, Maryam A., Condino-Neto, Antonio, Cole, Theresa, Eley, Brian, Erwa, Nahla H.H., Espinosa-Padilla, Sara, Faria, Emilia, Rosario Filho, Nelson A., Fuleihan, Ramsay, Galal, Nermeen, Garabedian, Elizabeth, Hintermeyer, Mary, Imai, Kohsuke, Irani, Carla, Kamal, Ebtihal, Kechout, Nadia, Klocperk, Adam, Levin, Michael, Milota, Tomas, Ouederni, Monia, Paganelli, Roberto, Pignata, Claudio, Qamar, Farah N., Quinti, Isabella, Qureshi, Sonia, Radhakrishnan, Nita, Rezaei, Nima, Routes, John, Singh, Surjit, Siniah, Sangeetha, Abdel-Hakam Taha, Intisar, Tanno, Luciana K., Van Dort, Ben, Volokha, Alla, and Sullivan, Kathleen

Published
2022
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6. CD40 Ligand Deficiency in Latin America: Clinical, Immunological, and Genetic Characteristics

Author

França, Tábata Takahashi, Barreiros, Lucila Akune, Salgado, Ranieri Coelho, Napoleão, Sarah Maria da Silva, Gomes, Lillian Nunes, Ferreira, Janáira Fernandes Severo, Prando, Carolina, Weber, Cristina Worm, Di Gesu, Regina Sumiko Watanabe, Montenegro, Cecilia, Aranda, Carolina Sanchez, Kuntze, Gisele, Staines-Boone, Aidé Tamara, Venegas-Montoya, Edna, Becerra, Juan Carlos Aldave, Bezrodnik, Liliana, Di Giovanni, Daniela, Moreira, Ileana, Seminario, Gisela Analia, Raccio, Andrea Cecilia Gómez, Dorna, Mayra de Barros, Rosário-Filho, Nelson Augusto, Chong-Neto, Herberto Jose, de Carvalho, Elisa, Grotta, Milena Baptistella, Orellana, Julio Cesar, Dominguez, Miguel Garcia, Porras, Oscar, Sasia, Laura, Salvucci, Karina, Garip, Emilio, Leite, Luiz Fernando Bacarini, Forte, Wilma Carvalho Neves, Pinto-Mariz, Fernanda, Goudouris, Ekaterini, Nuñez, María Enriqueta Nuñez, Schelotto, Magdalena, Ruiz, Laura Berrón, Liberatore, Diana Inés, Ochs, Hans D., Cabral-Marques, Otavio, and Condino-Neto, Antonio

Published
2022
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9. Current situation of allergy education in Mexico and other parts of Latin America

Author

Gonzalez-Diaz, Sandra Nora, Martin, Bryan, de Lira-Quezada, Cindy Elizabeth, Villarreal-Gonzalez, Rosalaura Virginia, Guzman-Avilan, Rosa Ivett, Macías-Weinmann, Alejandra, Ortega-Martell, José Antonio, Macouzet-Sanchez, Carlos, Sánchez-Borges, Mario, Rosario Filho, Nelson Augusto, Yañez, Anahí, Guzman-Melendez, María Antonieta, Cardona, Ricardo, Monge-Ortega, Olga Patricia, Cherrez-Ojeda, Ivan, Herrera-Castro, Dayanara, Valentin-Rostan, Marylin, Sisul-Alvariza, Juan Carlos, Ansotegui, Ignacio J., and Elizondo-Villarreal, Barbara

Published
2021
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10. Air pollution and indoor settings

Author

Rosário Filho, Nelson Augusto, Urrutia-Pereira, Marilyn, D'Amato, Gennaro, Cecchi, Lorenzo, Ansotegui, Ignacio J., Galán, Carmen, Pomés, Anna, Murrieta-Aguttes, Margarita, Caraballo, Luis, Rouadi, Philip, Annesi-Maesano, Isabella, Pawankar, Ruby, Chong-Neto, Herberto J., and Peden, David B.

Published
2021
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15. A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Gómez, R. Maximiliano, Jensen-Jarolim, Erika, Ebisawa, Motohiro, Luengo, Olga, Caraballo, Luis, Passalacqua, Giovanni, Poulsen, Lars K., Savi, Eleonora, Zuberbier, Torsten, Villa, Elisa, Oppenheimer, John, Asero, Riccardo, Bernstein, Jonathan, Bousquet, Jean, Cardona, Victoria, Cox, Lindo, Demoly, Pascal, Ferreira, Fatima, Giavina Bianchi, Pedro, Gonzalez Diaz, Sandra, Jakob, Thilo, Kase Tanno, Luciana, Kleine-Tebbe, Jorg, Levin, Michael, Martin, Bryan, Matricardi, Paolo Maria, Monge Ortega, Olga Patricia, Morais Almeida, Mario, Nunes, Carlos, Ortega Martell, José Antonio, Pawankar, Ruby, Renz, Harald, Rosário Filho, Nelson, Rouadi, Philip, Ruiba, Alessia, Sampson, Hugh, Sánchez Borges, Mario, Scala, Enrico, Schmid-Grendelmeier, Peter, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Valenta, Rudolf, van Hage, Marianne, Wong, Gary W.K., and Yáñez, Anahí

Published
2020
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16. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R. Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen-Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal M., DuBuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosário Filho, Nelson A., Rosenwasser, Lanny, Sánchez Borges, Mario A., Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2020
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18. IV Brazilian Consensus on Rhinitis – an update on allergic rhinitis

Author

Sakano, Eulalia, Sarinho, Emanuel S.C., Cruz, Alvaro A., Pastorino, Antonio C., Tamashiro, Edwin, Kuschnir, Fábio, Castro, Fábio F.M., Romano, Fabrizio R., Wandalsen, Gustavo F., Chong-Neto, Herberto J., Mello, João F. de, Jr., Silva, Luciana R., Rizzo, Maria Cândida, Miyake, Mônica A.M., Rosário Filho, Nelson A., Rubini, Norma de Paula M., Mion, Olavo, Camargos, Paulo A., Roithmann, Renato, Godinho, Ricardo N., Pignatari, Shirley Shizue N., Sih, Tania, Anselmo-Lima, Wilma T., and Solé, Dirceu

Published
2018
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19. Evaluation of corneal tomography in children and adolescents without ocular or systemic allergy.

Author

Moraes Neto, Roddie, Bordignon, Gabriel, Teixeira Flügel, Nayara, Tadashi Okuyama, Vinícius, Secco Rosário, Cristine, Caroline Serpe, Crislaine, Rosário Filho, Nelson Augusto, Chong Neto, Herberto José, and Reggiani Mello, Glauco Henrique

Subjects
ALLERGIC conjunctivitis, KERATOCONUS, CORNEA, CONJUNCTIVITIS, TEENAGERS, TOMOGRAPHY, SKIN tests, SLIT lamp microscopy, CORNEAL transplantation, THERAPEUTICS, CORNEAL topography
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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26. Risco de exacerbação de asma em adolescentes usuários de dispositivos eletrônicos de liberação de nicotina: uma revisão sistemática e metanálise

Author

Rocha, Anne Karoline Cardozo da, primary, Miyawaki, Andresa Emy, additional, Trombini, Marina Alves, additional, Rosa, Victória Augusta Cavassim Costa, additional, Prestes, Raul Cesar Santos, additional, Costa, Thamires Bezerra, additional, Chong-Neto, Herberto José, additional, Urrutia-Pereira, Marilyn, additional, Solé, Dirceu, additional, Rosário-Filho, Nelson Augusto, additional, Fernandes-Silva, Miguel Morita, additional, and Chong-Silva, Débora Carla, additional

Published
2023
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27. Practical guide for the use of immunobiologic agents in allergic diseases - ASBAI

Author

Sarinho, Filipe Wanick, primary, Rubini, Norma de Paula Motta, additional, Costa, Aldo José Fernandes, additional, Silva, Eduardo Costa de Freitas, additional, Monteiro, Fabrício Prado, additional, Serpa, Faradiba Sarquis, additional, Guidacci, Marta de Fátima Rodrigues da Cunha, additional, Antila, Martti Anton, additional, Cordeiro, Nelson Guilherme Bastos, additional, Agondi, Rosana Câmara, additional, Dortas Júnior, Sérgio Duarte, additional, Campos, Régis de Albuquerque, additional, Goudouris, Ekaterini Simões, additional, Kuschnir, Fábio Chigres, additional, Tebyriçá, João Negreiros, additional, and Rosário Filho, Nelson Augusto, additional

Published
2023
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28. Risk of asthma exacerbation in adolescent users of electronic nicotine delivery systems: a systematic review and meta-analysis

Author

Rocha, Anne Karoline Cardozo da, primary, Miyawaki, Andresa Emy, additional, Trombini, Marina Alves, additional, Rosa, Victória Augusta Cavassim Costa, additional, Prestes, Raul Cesar Santos, additional, Costa, Thamires Bezerra, additional, Chong-Neto, Herberto José, additional, Urrutia-Pereira, Marilyn, additional, Solé, Dirceu, additional, Rosário-Filho, Nelson Augusto, additional, Fernandes-Silva, Miguel Morita, additional, and Chong-Silva, Débora Carla, additional

Published
2023
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37. First Report of the Hyper-IgM Syndrome Registry of the Latin American Society for Immunodeficiencies: Novel Mutations, Unique Infections, and Outcomes

Author

Cabral-Marques, Otavio, Klaver, Stefanie, Schimke, Lena F, Ascendino, Évelyn H, Khan, Taj Ali, Pereira, Paulo Vítor Soeiro, Falcai, Angela, Vargas-Hernández, Alexander, Santos-Argumedo, Leopoldo, Bezrodnik, Liliana, Moreira, Ileana, Seminario, Gisela, Di Giovanni, Daniela, Raccio, Andrea Gómez, Porras, Oscar, Weber, Cristina Worm, Ferreira, Janaíra Fernandes, Tavares, Fabiola Scancetti, de Carvalho, Elisa, Valente, Claudia França Cavalcante, Kuntze, Gisele, Galicchio, Miguel, King, Alejandra, Rosário-Filho, Nelson Augusto, Grota, Milena Baptistella, dos Santos Vilela, Maria Marluce, Di Gesu, Regina Sumiko Watanabe, Lima, Simone, de Souza Moura, Leiva, Talesnik, Eduardo, Mansour, Eli, Roxo-Junior, Pérsio, Aldave, Juan Carlos, Goudouris, Ekaterine, Pinto-Mariz, Fernanda, Berrón-Ruiz, Laura, Staines-Boone, Tamara, Calderón, Wilmer O. Córdova, del Carmen Zarate-Hernández, María, Grumach, Anete S., Sorensen, Ricardo, Durandy, Anne, Torgerson, Troy R., Carvalho, Beatriz Tavares Costa, Espinosa-Rosales, Francisco, Ochs, Hans D., and Condino-Neto, Antonio

Published
2014
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39. Systematic review on fecal calprotectin in cystic fibrosis.

Author

Sampaio Lazzarotto, Eduarda, Ferreira de Melo Vasco, Jannaina, Führ, Fabiane, Antônio Riedi, Carlos, and Rosário Filho, Nelson Augusto

Subjects
CYSTIC fibrosis, CALPROTECTIN, CLINICAL trials, INTESTINAL diseases, GENETIC disorders
Abstract

Objectives: Fecal calprotectin is an inflammatory marker used for monitoring intestinal diseases. It has been studied as a marker of intestinal inflammation in cystic fibrosis (CF), a multisystemic genetic disease caused by alterations to the CFTR gene. Manifestations of the disease favor a systemic inflammation not limited to the respiratory tract, therefore, calprotectin is a non-invasive and effective diagnostic method. The aim of the study was to perform a systematic review of the literature with a qualitative synthesis of studies. Sources: The articles were selected from PubMed, Web of Science, Scielo and Lilacs. Summary of the findings: Nine studies were selected for that qualitative synthesis, one was a randomized clinical trial, and eight were case-control or cohort designs. Most studies have indicated that calprotectin is a marker of systemic inflammation in CF and not just intestinal inflammation. Calprotectin is an aid in monitoring inflammatory bowel conditions in patients with cystic fibrosis. Conclusion: Further studies should be conducted to investigate the role of this marker in the systemic inflammation of CF. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Erratum to "IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper" [World Allergy Organ J 13/2 (2020) 100080]

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R.Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J., Jensen-Jarolim, Erika, Fischer, David A., Haahtela, Tari, Antila, Martti, Bousquet, Jean J., Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal M., DuBuske, Lawrence M., Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L., Ledford, Dennis K., Monge Ortega, Olga Patricia, Morais-Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K., Pawankar, Ruby, Renz, Harald E., Romano, Antonino G., Rosário Filho, Nelson A., Rosenwasser, Lanny, Sánchez Borges, Mario A., Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Yu-Hor Thong, Bernard, Valenta, Rudolf, Wood, Robert A., and Zuberbier, Torsten

Published
2021
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41. Expanding the Clinical and Genetic Spectrum of Human CD40L Deficiency: The Occurrence of Paracoccidioidomycosis and Other Unusual Infections in Brazilian Patients

Author

Cabral-Marques, Otavio, Schimke, Lena-Friederike, Pereira, Paulo Vítor Soeiro, Falcai, Angela, de Oliveira, João Bosco, Hackett, Mary J., Errante, Paolo Ruggero, Weber, Cristina Worm, Ferreira, Janaíra Fernandes, Kuntze, Gisele, Rosário-Filho, Nelson Augusto, Ochs, Hans D., Torgerson, Troy R., Carvalho, Beatriz Tavares Costa, and Condino-Neto, Antonio

Published
2012
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43. Incidence of cystic fibrosis in five different states of Brazil as determined by screening of p.F508del, mutation at the CFTR gene in newborns and patients

Author

Raskin, Salmo, Pereira-Ferrari, Lilian, Caldeira Reis, Francisco, Abreu, Fernando, Marostica, Paulo, Rozov, Tatiana, Cardieri, Joselina, Ludwig, Norberto, Valentin, Lairton, Rosario-Filho, Nelson Augusto, Camargo Neto, Eurico, Lewis, Eduardo, Giugliani, Roberto, Albuquerque Diniz, Edna Maria, Culpi, Lodercio, Phillip, John Atlas, III, and Chakraborty, Ranajit

Published
2008
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45. Investigación genética de la fisiopatología y del síntomas clínicos del Angioedema Hereditario

Author

Kruk, Tatielly, Fortunato, Lucas Marques, Moraes, Caroline Guth de freitas Batista de, Chong-Neto, Herberto José, Mikami, Liya Regina, Ferrari, Lilian Pereira, and Rosário Filho, Nelson

Subjects
Angioedemas Hereditários, Fisiopatología, Hereditary Angioedema, Pathophysiology, Mutación, Mutation, Fisiopatologia, Genetics, Bradicinina, Bradykinin, Genética, Mutação
Abstract

Hereditary Angioedema (HAE) is a disorder unknown by many health professionals, thus being underdiagnosed. The objective of the study was to analyze the articles related to the topic addressed in the last 5 years. HAE is a rare and severe genetic disease of the immune system, caused by a deficiency of the C1 esterase inhibitor (C1-INH), presenting an autosomal dominant inheritance. It is classified into 3 phenotypes: quantitative deficiency of the C1-INH inhibitor, dysfunction of the C1-INH and normal C1-INH. Mutations in several genes are associated with the HAE phenotype; patients with deficiency and dysfunction of the C1-INH protein have mutations in the SERPING1 gene, and patients with normal C1-INH may present mutations in the following genes: F12, angiopoietin (ANGPT1), plasminogen (PLG) or kininogen (KNG1). The symptoms of HAE include recurrent edema in several body parts, both on the skin and on internal organs. For the preparation of this study an integrative literature review was carried out, the articles were searched in three electronic databases (Google Scholar, PubMed and Scielo) using the descriptors “hereditary angioedema”, “mutations”, “bradykinin”, “C1-INH”, “SERPING1”, “plasminogen”, “angiopoietin”, “F12” and “kininogen”, connected by Boolean operators AND and OR. We found a a total of 874 articles, and after the screening, 32 articles were evaluated. This research enabled the understanding not only of the precursor mechanisms that leads to the development of this disease, but also of the genetic mutations responsible for the variety of HAE’s clinical manifestations, corroborating the building of knowledge of professionals involved in the diagnosis and treatment of this disorder. El angioedema hereditario (AEH) es una enfermedad poco conocida por los profesionales de la salud, y por consiguiente está infradiagnosticada. El objetivo del estúdio fue analizar artículos relacionados con el tema abordado, en los últimos 5 años. El AEH es una enfermedad genética del sistema inmunológico, poco frecuente pero severa, que se hereda de forma autosómica dominante y se adquiere por el déficit de C1 Inhibidor (C1-INH) de la esterasa. La enfermedad está dividida en 3 fenotipos: déficit cuantitativo de C1-INH, disfunción de C1-INH y niveles normales de C1-INH. Las mutaciones en varios genes se relacionan con el AEH, como, por ejemplo, los pacientes con déficit y disfunción de la proteína C1-INH presentan mutaciones en el gen SERPING1, y los pacientes con niveles normales de C1-INH pueden presentar mutaciones en los siguientes genes: F12, angiopoyetina (ANGPT1), plasminógeno (PLG) o cininógeno (KNG1). Los síntomas del AEH se caracterizan por la presencia recurrente de edema que afecta varias partes del cuerpo, localizados tanto en piel como en órganos internos. Para la elaboración del estudio, se ha realizado la revisión integradora través de una base de datos electrónica, tales como Google Scholar, PubMed y Scielo, utilizando los descriptores "angioedema hereditario", "mutaciones", "bradicinina", "C1-INH", "SERPING1", “plasminógeno", "angiopoyetina", "F12" y "cininógeno", conectados mediante los operadores booleanos AND y OR. La búsqueda en la base de datos ha obtenido un total de 874 artículos, de los cuales 32 artículos fueron evaluados después de una selección. El estudio permitió comprender no sólo los mecanismos precursores que conducen al desarrollo de la enfermedad, sino también las mutaciones genéticas responsables de las diferentes formas de manifestaciones clínicas del AEH. De esta forma, se pretende contribuir a la construcción de conocimiento de los profesionales involucrados en el diagnóstico y tratamiento de la patología. Angioedema Hereditário (AEH) é uma doença pouco conhecida por profissionais da saúde, portanto subdiagnosticada. O objetivo do estudo, foi analisar artigos referentes à temática abordada dos últimos 5 anos. AEH é uma doença genética rara e grave do sistema imunológico, de caráter autossômico dominante, causada pela deficiência de inibidor de C1 esterase (C1-INH). Classificada em 3 fenótipos: deficiência quantitativa do inibidor de C1-INH, disfunção de C1-INH e C1-INH normal. Mutações em diversos genes estão associadas ao fenótipo do AEH, pacientes com deficiência e disfunção da proteína C1-INH possuem mutações no gene SERPING1 e pacientes com C1-INH normal, podem apresentar mutações nos genes F12, angiopoietina (ANGPT1), plasminogênio (PLG) ou cininogênio (KNG1). Os sintomas do AEH são caracterizados por edemas recorrentes em várias partes do corpo, tanto em pele como órgãos internos. Para a elaboração deste estudo realizou-se uma revisão integrativa da literatura, os artigos foram pesquisados ​​em três bases de dados eletrônicas, Google Scholar, PubMed e Scielo, utilizando os descritores “angioedema hereditário”, “mutações”, “bradicinina”, “C1-INH”, “SERPING1”, “plasminogênio”, “angiopoietina”, “F12” e “cininogênio”, conectados por operadores boleanos AND e OR. A pesquisa no banco de dados revelou um total de 874 artigos, após triagem, 32 artigos foram avaliados. Com a pesquisa tornou-se possível compreender não somente os mecanismos percursores que levam ao desenvolvimento da doença, mas também as mutações genéticas responsáveis pelas diversas formas de manifestações clínicas do AEH, corroborando a construção de conhecimento dos profissionais envolvidos no diagnóstico e tratamento da patologia.

Published
2020

46. A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@):Update 2020

Author

Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Gómez, R. Maximiliano, Jensen-Jarolim, Erika, Ebisawa, Motohiro, Luengo, Olga, Caraballo, Luis, Passalacqua, Giovanni, Poulsen, Lars K., Savi, Eleonora, Zuberbier, Torsten, Villa, Elisa, Oppenheimer, John, Asero, Riccardo, Bernstein, Jonathan, Bousquet, Jean, Cardona, Victoria, Cox, Lindo, Demoly, Pascal, Ferreira, Fatima, Giavina Bianchi, Pedro, Gonzalez Diaz, Sandra, Jakob, Thilo, Kase Tanno, Luciana, Kleine-Tebbe, Jorg, Levin, Michael, Martin, Bryan, Matricardi, Paolo Maria, Monge Ortega, Olga Patricia, Morais Almeida, Mario, Nunes, Carlos, Ortega Martell, José Antonio, Renz, Harald, Rosário Filho, Nelson, Rouadi, Philip, Ruiba, Alessia, Sampson, Hugh, Sánchez Borges, Mario, Scala, Enrico, Schmid-Grendelmeier, Peter, Senna, Gian Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Valenta, Rudolf, van Hage, Marianne, Wong, Gary W.K., Yáñez, Anahí, Ansotegui, Ignacio J., Melioli, Giovanni, Canonica, Giorgio Walter, Gómez, R. Maximiliano, Jensen-Jarolim, Erika, Ebisawa, Motohiro, Luengo, Olga, Caraballo, Luis, Passalacqua, Giovanni, Poulsen, Lars K., Savi, Eleonora, Zuberbier, Torsten, Villa, Elisa, Oppenheimer, John, Asero, Riccardo, Bernstein, Jonathan, Bousquet, Jean, Cardona, Victoria, Cox, Lindo, Demoly, Pascal, Ferreira, Fatima, Giavina Bianchi, Pedro, Gonzalez Diaz, Sandra, Jakob, Thilo, Kase Tanno, Luciana, Kleine-Tebbe, Jorg, Levin, Michael, Martin, Bryan, Matricardi, Paolo Maria, Monge Ortega, Olga Patricia, Morais Almeida, Mario, Nunes, Carlos, Ortega Martell, José Antonio, Renz, Harald, Rosário Filho, Nelson, Rouadi, Philip, Ruiba, Alessia, Sampson, Hugh, Sánchez Borges, Mario, Scala, Enrico, Schmid-Grendelmeier, Peter, Senna, Gian Enrico, Sisul, Juan Carlos, Tang, Mimi L.K., Valenta, Rudolf, van Hage, Marianne, Wong, Gary W.K., and Yáñez, Anahí

Abstract

Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for PAMD@. PAMD@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies.

Published
2020

47. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, Zuberbier, Torsten, Ansotegui, Ignacio J, Melioli, Giovanni, Canonica, Giorgio Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean J, Cardona, Victoria, Demoly, Pascal M, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, and Zuberbier, Torsten

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

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