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Your search keyword '"Rosa H Zwarthoed"' showing total 2 results
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2 results on '"Rosa H Zwarthoed"'

1. Impact of maximal extent of resection on postoperative deficits, patient functioning, and survival within clinically important glioblastoma subgroups

Author

Jasper K W Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah Lee Nawabi, Georges Versyck, Charissa A C Jessurun, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens M F Dirven, Steven De Vleeschouwer, Arnaud J P E Vincent, Marike L D Broekman, Neurology, and Neurosurgery

Subjects
Cancer Research, Science & Technology, SURGERY, Clinical Neurology, glioblastoma, SURGICAL RESECTION, gross-total resection, ASSOCIATION, extent of resection, survival, SAFE, MULTIFORME, Oncology, TUMOR VOLUME, SDG 3 - Good Health and Well-being, RECURRENT GLIOBLASTOMA, postoperative deficits, Neurology (clinical), Neurosciences & Neurology, Life Sciences & Biomedicine
Abstract

Background The impact of extent of resection (EOR), residual tumor volume (RTV), and gross-total resection (GTR) in glioblastoma subgroups is currently unknown. This study aimed to analyze their impact on patient subgroups in relation to neurological and functional outcomes. Methods Patients with tumor resection for eloquent glioblastoma between 2010 and 2020 at 4 tertiary centers were recruited from a cohort of 3919 patients. Results One thousand and forty-seven (1047) patients were included. Higher EOR and lower RTV were significantly associated with improved overall survival (OS) and progression-free survival (PFS) across all subgroups, but RTV was a stronger prognostic factor. GTR based on RTV improved median OS in the overall cohort (19.0 months, P Conclusions Maximum resection was especially beneficial in the subgroups aged

Published
2023

2. Effect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP)

Author

Jasper K W Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah L Nawabi, Charissa A C Jessurun, Georges Versyck, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens M F Dirven, Steven De Vleeschouwer, Marike L D Broekman, Arnaud J P E Vincent, and Neurosurgery

Subjects
Aged, 80 and over, Cohort Studies, Oncology, Brain Neoplasms, Humans, Female, Wakefulness, Glioblastoma, Propensity Score, Craniotomy, Aged, Retrospective Studies
Abstract

Background: Awake mapping has been associated with decreased neurological deficits and increased extent of resection in eloquent glioma resections. However, its effect within clinically relevant glioblastoma subgroups remains poorly understood. We aimed to assess the benefit of this technique in subgroups of patients with glioblastomas based on age, preoperative neurological morbidity, and Karnofsky Performance Score (KPS). Methods: In this propensity score-matched analysis of an international, multicentre, cohort study (GLIOMAP), patients were recruited at four tertiary centres in Europe (Erasmus MC, Rotterdam and Haaglanden MC, The Hague, Netherlands, and UZ Leuven, Leuven, Belgium) and the USA (Brigham and Women's Hospital, Boston, MA). Patients were eligible if they were aged 18–90 years, undergoing resection, had a histopathological diagnosis of primary glioblastoma, their tumour was in an eloquent or near-eloquent location, and they had a unifocal enhancing lesion. Patients either underwent awake mapping during craniotomy, or asleep resection, as per treating physician or multidisciplinary tumour board decision. We used propensity-score matching (1:3) to match patients in the awake group with those in the asleep group to create a matched cohort, and to match patients from subgroups stratified by age (

Published
2022

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