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4 results on '"Rosa de Alarcón"'

1. Citrate versus Acetate-Based Dialysate in On-Line Haemodiafiltration. A Prospective Cross-Over Study

Author

Rosa de Alarcón, Cristina Jimeno, Susana Roca, Laura Bucalo, Gracia Álvarez, María Ángeles García, María Soledad Ros, Manuel Molina Nuñez, and Isabel Villegas

Subjects
Adult, Male, medicine.medical_specialty, Alkalosis, medicine.medical_treatment, Bicarbonate, chemistry.chemical_element, Hemodiafiltration, Acetates, Acid-Base Imbalance, Calcium, Gastroenterology, chemistry.chemical_compound, Dialysis Solutions, Internal medicine, medicine, Humans, Citrates, Prospective Studies, Dialysis, Aged, Aged, 80 and over, Calcium metabolism, Cross-Over Studies, biology, Chemistry, Beta-2 microglobulin, C-reactive protein, Hematology, General Medicine, Hydrogen-Ion Concentration, Middle Aged, medicine.disease, Surgery, Bicarbonates, C-Reactive Protein, Nephrology, biology.protein, Partial Thromboplastin Time, beta 2-Microglobulin, Acid–base imbalance
Abstract

Background and Aims: A bicarbonate dialysate acidified with citrate (CD) has been reported to have local anticoagulant effect and improves biocompatibility. This study examines the effect of CD on dialysis efficiency, coagulation, acid-base status, electrolytes, and inflammation in patients in on-line hemodiafiltration (OL-HDF). Methods: 35 patients in OL-HDF were enrolled in a prospective, cross-over study for a 24-week period and two phases alternating CD and acetate dialysate fluid (AD). Parameters on study were predialysis levels of bicarbonate and ionic calcium, reactive C Protein (CRP), and beta-2 microglobulin (B2MG) and postdialysis levels of activated tromboplastine time, bicarbonate, and ionized calcium. Results: No significant differences in coagulation parameters, pH, and predialysis bicarbonate were found. The postdialysis bicarbonate and postdialysis calcium were lower with CD. Dialysis efficiency was greater with CD. Regarding inflammatory parameters, both CRP and B2MG were lower using CD. Conclusion: The use of CD is safe and effective in OL-HDF, and it improves dialysis efficacy, postdialysis alkalosis, and inflammation.

Published
2015
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2. Annual Congress of the Chinese Blood Purification Center Administration Committee. September 25-28, 2014, Guangzhou: Abstracts

Author

Giovanni Grazi, Jicheng Zhang, Sampson Antwi, Jonathan M. Rubin, Leonardo C Ribeiro, Hanjie Zhang, Jing Gao, Gioacchino Li Cavoli, Susana Roca, Rainer Himmele, M. Ted Ferris, Paolo Armignacco, Alberto Rosati, Anna Meyring-Wösten, William J. Federspiel, Nefroint investigators, Fansan Zhu, Corinne E. Zeller-Knuth, Jose A. Diaz-Buxo, Gianluca Villa, April Bowman, Laura Bucalo, Grant H. Kruger, Marianne Wilhelmi, Daniel Muñoz-Aguayo, Sarah Cohen, Alberto A.E. Bertelli, Kristi Bickford, Aldo Casani, Mar Orzáez, Ekou Niamien, Emma Arcos, Jeremy D. Kimmel, Rafael de la Torre, Carmela Zagarrigo, Florence Desrosiers, Beatriz Santamaría, A. Mary Vilay, Michael J. Germain, María Ángeles García, Michael Heung, Jwa-Kyung Kim, Rinaldo Bellomo, Giovanni Manca Rizza, Karina Javalkar, Isaac Teitelbaum, Onofrio Schillaci, J. Michael Yardman-Frank, Juan Jesus Carrero, Laurence Adonis-Koffy, Gérard Abel, Len A. Usvyat, M. Valles, Marina Abramyan, Renhua Lu, Jordi Calabia, William F. Weitzel, Massimo Antonelli, Elizabeth A. Hughson, A. Phillips, John A. Kellum, Kyu Hun Choi, Khaled Abdel-Kader, Oleh Akchurin, Aileen Grassman, Pessa Albert Coulibaly, Jose J. Zaragoza, Alexandra Ternier, Jessica Cuttance, Krotenko Np, Michael J. Somers, Matteo Ruggeri, Alberto Ortiz, Claudio Ronco, Craig S. Wong, Ludimila Guedim de Campos, Maggie Han, María J. Vicent, Manuel Molina Nuñez, Frederick J. Kaskel, Angel Celdrán, Francesco Garzotto, Panduranga Rao, Roberto Bigazzi, Paul Zabetakis, Corrado Bellini, Druckerei Stückle, Mattia Palmeri, Alvaro C. Ucero, Cristina Jimeno, Aashish Sharma, Audie Métayer, Isabel Villegas, Sabrina Paoletti, Sarbjit V. Jassal, Donald Maberry, Stanley Fan, Massimiliano Migliori, Xiaoqi Xu, Maribel Covas, Jean Baptiste Yaokreh, Jacob Volpe, Peter Kotanko, Morton Satin, Maria E. Ferris, Popov Da, Marina Plyushch, Morgan Lam, Mathias Schaller, Keisha L. Gibson, Alberto Benito-Martin, Melissa Mendoza, Michail Yaroustovsky, Dalia Yousif, Anna Lorenzin, Keisha Gibson, Vincenzo Panichi, Sung Kyu Ha, Adriana Di Giorgio, Jordi Comas, Marco Sartori, Tancredi Vincenzo Li Cavoli, Hyeong Cheon Park, Karin True, Judith Exantus, Jean-Hénold Buteau, Sung Jin Moon, Gnenefoly Diarrassouba, Dorey A. Glenn, Sanah Parvez, Mark Unruh, Rasha Hussein, Mikhail Artemyev, Viviane Calice-Silva, Jung Eun Lee, Zhiyong Peng, Ugo Rotolo, Isa F. Ashoor, Montserrat Fitó, Alan Vollmer, María Soledad Ros, Hans Oberleithner, Alessandro Sgambato, Renee-Claude Mercier, James A. Hamilton, Nathan W. Levin, Alessia Scatena, Mauro Neri, Paul Balter, Gero von Gersdorff, Kenneth R. Wilund, Ekaterina Rogalskaya, Soo Young Yoon, Elizabeth Ley Oei, Joseph L. Bull, Roberto Pecoits-Filho, Danielle Marcelli, Paul K. Whelton, Franca Servillo, Michael Etter, Rosa de Alarcón, Xianglong Wang, Shin Wook Kang, Rafael Selgas, Gracia Álvarez, Mi Kyung Song, Kerry Anne Rambaran, and Marta Ruiz-Ortega

Subjects
medicine.medical_specialty, Nephrology, business.industry, Emergency medicine, medicine, Blood purification, Center (algebra and category theory), Hematology, General Medicine, business, Administration (government)
Published
2015
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3. Change in Darbepoetin Alfa Administration Schedule Affects Erythropoiesis-Stimulating Agent Resistance in Patients with Chronic Kidney Disease Receiving Hemodialysis

Author

Maria José Navarro, María Ángeles García, Manuel Molina, Rosa de Alarcón, Gracia Álvarez, and Carmen de Gracia

Subjects
Male, Nephrology, medicine.medical_specialty, Darbepoetin alfa, Anemia, medicine.drug_class, medicine.medical_treatment, Drug Resistance, Critical Care and Intensive Care Medicine, Gastroenterology, Drug Administration Schedule, Renal Dialysis, Internal medicine, medicine, Humans, Prospective Studies, Dosing, Erythropoietin, business.industry, General Medicine, Middle Aged, medicine.disease, Erythropoiesis-stimulating agent, Surgery, Hematinics, Kidney Failure, Chronic, Erythropoiesis, Female, Hemodialysis, business, Kidney disease, medicine.drug
Abstract

One hundred and four patients receiving hemodialysis and undergoing anaemia treatment with darbepoetin alfa intravenously once weekly were switched to a biweekly dosing schedule and followed for 24 weeks. The darbepoetin alfa dose was adjusted to maintain the target Hb concentration of 11-14 g/dL. A significant decline in the erythropoiesis-stimulating agent resistance index was observed over the 24-week follow-up, beginning with week 16, whereas the mean dose of darbepoetin alfa did not change significantly after switching to the biweekly dosing schedule. Other factors that might affect resistance to erythropoiesis remained unchanged.

Published
2008
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