104 results on '"Rosales, O."'
Search Results
2. Evolución clínica y radiológica en el tratamiento de hernia discal con prótesis PDN-SOLO con ancla: seguimiento mínimo a tres años Evolução clínica e radiológica no tratamento da hérnia discal com prótese PDN-SOLO com ancora: seguimento mínimo por três anos Clinical and radiological development in the treatment of intervertebral disc with prosthesis PDN-SOLO with anchors: follow-up to a minimum of three years
- Author
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Alejandro Antonio Reyes-Sánchez, Nicasio Arriada, Víctor Miramontes M., Armando Alpizar A., and Luis M. Rosales O.
- Subjects
Desplazamiento del disco intervertebral ,Biomecánica ,Prótesis articulares ,Deslocamento do disco intervertebral ,Biomecânica ,Prótese articular ,Intervertebral disk displacement ,Biomechanics ,Joint prosthesis ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
OBJETIVO: las prótesis de núcleo (PDN-SOLO) reconstruyen la anatomía y preservan la biomecánica del disco intervertebral con un índice de migración de 10% y de hundimiento de 19%. Por eso, proponemos un sistema de fijación para evitar estas complicaciones. MÉTODOS: fueron utilizados veinte pacientes con seguimiento mínimo de tres años. La valoración de dolor con EVA, función con Escala de Oswestry (EO) y disco por estudios radiográficos y resonancia magnética fueron aplicadas. El análisis estadístico fue por t de Student. RESULTADOS: El grupo comprende 8 mujeres y 12 hombres con una edad promedio de 37.6 años. Los valores preoperatorios de EVA fueron 7.6 puntos y EO de 67%, la altura del espacio intervertebral (El) de 7.67 mm. A tres años, EVA de dolor de 0.7 y EO a menos de 6% (pOBJETIVO: as próteses de núcleo (PDN-SOLO) reconstituem a anatomia e preservam a biomecânica do disco intervertebral, com um índice de migração de 10% e de afundamento de 19%. Por isso, foi proposto um sistema de fixação para evitar essas complicações. MÉTODOS: foram utilizados 20 pacientes com seguimento mínimo de três anos. A avaliação da dor com EVA, função com Escala de Oswestry (EO) e disco por estudos radiológicos e ressonância magnética foram aplicados. A análise estatística foi por teste t de Student. RESULTADOS: Fizeram parte do estudo 12 homens e 8 mulheres, com média de idade de 37,6 anos. Valores pré-operatórios da EVA foram de 7,6 pontos e EO de 67%, a altura do espaço intervertebral (EI) de 7,67 mm. Durante três anos, a EVA de dor foi de 0,7 e a EO foi menos de 6% (pOBJECTIVE: The prosthetic nucleus (PDN-SOLO) reconstruct the anatomy and preserve the biomechanics of intervertebral disc with a migration rate of 10% and sinking rate of 19%. Therefore, a fixing system to avoid these complications was proposed. METHODS: A total of 20 patients were followed-up for at least three years. The assessment of pain with VAS, Oswestry Scale function (OS) and disk by radiological studies and magnetic resonance imaging were applied. Statistical analysis was made by Student's t-test. RESULTS: The subjects were 12 men and 8 women with a mean age of 37.6 years. VAS preoperative values were 7.6 points and OS 67%, the height of intervertebral space was 7.67 mm. For three years, the VAS pain score was 0.7 and OS less than 6% (p
- Published
- 2010
- Full Text
- View/download PDF
3. Proteasome activity and proteasome subunit transcripts in human spermatozoa separated by a discontinuous Percoll gradient
- Author
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Rosales, O., Opazo, C., Diaz, E. S., Villegas, J. V., Sanchez, R., and Morales, P.
- Published
- 2011
- Full Text
- View/download PDF
4. CML-319: Impact of Insurance Differences in Outcomes in Colombian Patients with Chronic Myeloid Leukemia (CML)
- Author
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Carmen Rosales O, Guillermo Quintero, Mónica Osuna, Angela María Peña, Rigoberto Gomez, Lina Gaviria, Henry Idrobo, María Helena Solano, Isabel Munevar, Alicia Maria Henao Uribe, José Domingo Saavedra, Claudia Sossa Melo, Lina Abenosa, Virginia Abello Polo, Jheremy Reyes, Kenny M Gaìvez, and Juan Manuel Herrera
- Subjects
Cancer Research ,medicine.medical_specialty ,business.industry ,Hazard ratio ,Imatinib ,Context (language use) ,Hematology ,Dasatinib ,Disease registry ,Oncology ,Nilotinib ,Internal medicine ,Cohort ,medicine ,Sokal Score ,business ,medicine.drug - Abstract
Context Adherence is a key factor for good outcomes in CML. There are two types of insurance in Colombia: Contributory (CS) and Subsidized Systems (SS), which provide highly unequal access to Tyrosine Kinase Inhibitors (TKI) for CML. Objective The aim of this report is to compare outcomes in patients with different access to TKI and analyze other factors that affect progression-free survival (PFS). Design The Colombian Association of Hematology and Oncology (ACHO)'s hematological disease registry (RENEHOC) is a multicenter study; it has collected information on CML patients since 2019, in 14 centers with institutional Ethics Committee approval. Setting RENEHOC is a real-world registry and captures information from academic and general community centers. Patients or other participants 357 CML adult patients treated in the last 20 years. Interventions Treatment was according to investigators' preferences. Imatinib was first-line treatment for 223 patients (62.4%), dasatinib for 69 (19.4%) and nilotinib 53 (14.8%); 47.9% required a second line of treatment. Main outcome measures Primary end points were Optimal Response (OR) according to LeukemiaNet 2020 definition and progression-free survival (PFS) rates. The Kaplan-Meier method was used to assess PFS, and hazard ratios (HR) using Cox proportional regression modeling were estimated. Results Mean age was 54 years (19–92), 60.1% were males, most patient were diagnosed in chronic phase (92%) and 36% were high Sokal. At a median follow for the entire cohort of 69 months (1–228), 60% of patients were in OR, including 11 patients in treatment-free remission (TFR). There were no significant differences between contributory and subsidized cohorts in terms of patient or disease characteristics. 76% of patients were in OP at the last visit in the CS in comparison to 48% for the SS cohort. Ten patients died, all CML-related. The only significant prognosis factors associated with PFS were Sokal score (mean PFS: 57 months low/int vs 39 high; p=0.012) and type of insurance (mean PFS 70 months for CS vs 57.7 for SS; p=0003). Conclusions This report suggests that differences in access to TKI in CML according to insurance regimes results in significantly different PFS. This is the first time in the country that the impact of these attention inequalities in CML patient care have been demonstrated. Funding ACHO has received grants for RENEHOC project from Takeda, Abbvie, Amgen, Dr. Reddy's.
- Published
- 2020
5. Signal transduction pathways in vascular cells exposed to cyclic strain
- Author
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Sumpio, B. E., primary, Du, W., additional, Cohen, C. R., additional, Evans, L., additional, Isales, C., additional, Rosales, O. R., additional, and Mills, I., additional
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- 1994
- Full Text
- View/download PDF
6. A Reformulation for the Problem of Scheduling Unrelated Parallel Machines with Sequence and Machine Dependent Setup Times
- Author
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Avalos-Rosales, O., Ada Alvarez, and Angel-Bello, F.
- Abstract
In this paper we propose an improved formulation for an unrelated parallel machine problem with machine and job sequence-dependent setup times that outperforms the previously published formulations regarding size of instances and CPU time to reach optimal solutions. The main difference between the proposed formulation and previous ones is the way the makespan has been linearized. It provides improved dual bounds which speeds up the solution process when using a branch-and-bound commercial solver. Computational experiments show that, using this model, it is possible to solve instances four times larger than what was previously possible using other mixed integer programming formulations in the literature and obtain optimal solutions on instances of the same size up to three orders of magnitude faster.
- Published
- 2013
7. Evaluación sensorial de lonjas de jamón cocido y pechuga de pavo, recubiertas con películas antimicrobianas de alginato de sodio
- Author
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Rosales O., Yolima Beatriz, Raybaudi Massilia, Rosa, Medina, Ana Luisa, Mosqueda Melgar, Jonathan, and Tomé, Elisabetta
- Subjects
Revistas ,Prueba sensorial ,Nisina ,Oregano essential oil ,Antimicrobial films ,Garlic essential oil ,Artículos Originales [Revista de la Facultad de Farmacia] ,Facultad de Farmacia y Bioanálisis ,Revista de la Facultad de Farmacia ,Aceite esencial de orégano ,Sensory test ,Medicina y Salud ,Aceite esencial de ajo ,Películas antimicrobianas ,Nisin - Abstract
Entre los compuestos antimicrobianos agregados a las películas para recubrir alimentos, se encuentran aceites esenciales, extractos de plantas y especias, estos han demostrado ser efectivos contra Salmonella, Listeria y S. aureus, pero su utilización requiere un seguimiento ante la posibilidad de producir cambios sensoriales en alimentos. El objetivo de este trabajo fue realizar una evaluación sensorial para conocer el nivel de aceptación del consumidor de lonjas de jamón cocido y pechuga de pavo recubiertas con películas a base de alginato de sodio (2 %), nisina (1000 UI/mL) y aceites esenciales de ajo y orégano (0,25 %), incorporados como antimicrobianos. Se aplicó una prueba hedónica y evaluó el color, olor y sabor, con un panel no entrenado de 30 evaluadores. Los resultados reflejaron el color como único atributo que no se vio afectado por la aplicación de películas, el mismo fue percibido igual por los catadores tanto en muestras sin películas (SP) como en muestras con películas con antimicrobianos (PCA) y sin antimicrobianos (PSA) no encontrándose diferencias significativas (p< 0,05). En relación al olor y sabor se detectaron diferencias significativa (p< 0,05) entre las muestras SP y las muestras PCA y PSA. Los resultados señalaron el sabor como único atributo determinante en la elección de lonjas de jamón cocido y pechuga de pavo. El grado de aceptabilidad de los catadores fue mayor para las muestras SP, posteriormente las muestras PSA y finalmente las muestras PCA. Sin embargo, estas últimas no fueron totalmente rechazadas ya que obtuvieron puntuaciones iguales o superiores a 5 puntos. Among the antimicrobial compounds used in preparing films antimicrobial for coating foods are essential oils, plant extracts and spices, which have proved be effective against Salmonella, Listeria and S. aureus, but their use require monitoring at the possibility of producing sensory changes in food. The objective of this study was to conduct a sensory evaluation to determine the level of acceptance by the consumer of slices of cooked ham and turkey breast coated with films based on sodium alginate (2 %), nisin (1000 IU/mL), essential oils of oregano and garlic (0.25 %) incorporated as antimicrobials. A hedonic test was applied and evaluated the color, smell and taste, with an untrained panel of 30 evaluators. The results reflected color as a unique attribute that was not affected by the application of the films, it was perceived equally by the panelists in both samples filmless (SP) and samples with antimicrobials films (PCA) without antimicrobial (PSA) with no significant differences (p< 0.05). Regarding the smell and taste significant differences (p< 0.05) between samples filmless (SP) and samples with antimicrobial films (PCA) and films without antimicrobials (PSA) were detected. The results reflect the taste as the determining attribute in choosing slices of ham and turkey breast. The results indicate the taste attribute as the sole determinant in choosing slices of cooked ham and turkey breast. The degree of acceptability of panelists was greater for SP samples subsequently PSA samples and finally the PCA samples. However, the latter were not completely rejected because they scored at above of 5 points. 23-28 yolima@ula.ve analui@ula.ve Semestral
- Published
- 2016
8. Estudio del crecimiento bacteriano. Enfoque de análisis de datos con medidas repetidas
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Peña G Jesús A, Rosales O., Yolima Beatriz, and Orlandoni M., Giampaolo
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Artículo Original [Revista de la Facultad de Farmacia] ,Bacterial growth ,Revistas ,Medicina y Salud ,Medidas repetidas ,Crecimiento bacteriano ,Repeated measures ,Facultad de Farmacia y Bioanálisis ,Covariance structure ,Estructura de covarianza ,Universidad de Los Andes (ULA) ,Revista de la Facultad de Farmacia - Abstract
Los análisis de datos para medidas repetidas se aplican a un conjunto de mediciones de la misma variable tomadas sobre la misma unidad experimental a lo largo de tiempo, donde los períodos de observación son establecidos por el investigador. Esta estructura de datos, por lo general causa que las varianzas y correlaciones sean diferentes en el tiempo y, por tal razón, no es apropiado analizar los datos mediante un análisis estadístico clásico. Este artículo explica la metodología adecuada haciendo uso de datos de crecimiento bacteriano en el jamón de pavo, mediante un modelo factorial con errores aleatorios dependientes del tiempo usando la estructura de covarianza ANTE(1) elegido por medio de los criterios AIC, BIC y AICC. El procesamiento de los datos se realizó con el PROC MIXED del SAS, que usa como método de estimación de los parámetros la Máxima Verosimilitud Residual (REML) por defecto, empleado para modelos de efectos mixtos, debido a que admite el modelamiento de la estructura de covarianza de los datos. Aplicar esta metodología estadística a la variable crecimiento bacteriano, nos llevó a la conclusión de que el uso de aceites esenciales con película favorece en la conservación del jamón de pavo en el tiempo. Data analysis for repeated measures apply to a set of measurements of the same variable taken on the same experimental unit over time, where the observation periods are set by the researcher. This data structure usually causes the variances and correlations are different in time, and for this reason it is not appropriate to analyze the data using classical statistical analysis. This article explains the proper methodology using data of bacterial growth in turkey ham, using a factorial model with time-dependent random errors through a covariance structure model ANTE (1) chosen by the AIC criteria, BIC and AICC. The data processing was performed using PROC MIXED of SAS, using as a method of estimating the parameters Maximum Residual Likelihood (REML) by default, employed for mixed effects models because modeling supports the covariance structure of the data. Apply this to variable growth methodology, took us to the conclusion that the use of essential oils without film promotes the conservation of turkey ham in time. 8 - 17 yolima@ula.ve orlandon@ula.ve Semestral
- Published
- 2016
9. Evolución clínica y radiológica en el tratamiento de hernia discal con prótesis PDN-SOLO con ancla: seguimiento mínimo a tres años
- Author
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Luis M Rosales O, Víctor Miramontes M, Armando Alpízar A, Alejandro Antonio Reyes-Sánchez, and Nicasio Arriada
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Orthodontics ,business.industry ,medicine.medical_treatment ,Intervertebral disc ,Prosthesis ,medicine.anatomical_structure ,Desplazamiento del disco intervertebral/radiografía ,Radiological weapon ,medicine ,Prótesis articulares ,Orthopedics and Sports Medicine ,Surgery ,Neurology (clinical) ,business ,Biomecánica ,Desplazamiento del disco intervertebral/diagnóstico - Abstract
OBJETIVO: las prótesis de núcleo (PDN-SOLO) reconstruyen la anatomía y preservan la biomecánica del disco intervertebral con un índice de migración de 10% y de hundimiento de 19%. Por eso, proponemos un sistema de fijación para evitar estas complicaciones. MÉTODOS: fueron utilizados veinte pacientes con seguimiento mínimo de tres años. La valoración de dolor con EVA, función con Escala de Oswestry (EO) y disco por estudios radiográficos y resonancia magnética fueron aplicadas. El análisis estadístico fue por t de Student. RESULTADOS: El grupo comprende 8 mujeres y 12 hombres con una edad promedio de 37.6 años. Los valores preoperatorios de EVA fueron 7.6 puntos y EO de 67%, la altura del espacio intervertebral (El) de 7.67 mm. A tres años, EVA de dolor de 0.7 y EO a menos de 6% (p
- Published
- 2010
10. Mechanical, barrier and antimicrobial properties of chitosan films and alginate sodium films with essential oils and nisin
- Author
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Rosales O., Yolima Beatriz, Raybaudi Massilia, Rosa, Mosqueda Melgar, Jonathan, Tapia, María Soledad, and Tomé, Elisabetta
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Artículo Original [Revista de la Facultad de Farmacia] ,Revistas ,Medicina y Salud ,Facultad de Farmacia y Bioanálisis ,Revista de la Facultad de Farmacia - Abstract
7-16 yolima@ula.ve, yolibet32@yahoo.com Semestral
- Published
- 2012
11. Descentralización del Estado, crisis económica mundial y oportunidades locales en América Latina
- Author
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Rosales O,Mario
- Subjects
gobiernos locales ,crisis mundial ,Latinoamérica ,descentralización política - Abstract
Este texto analiza el proceso de descentralización política desarrollado en Latinoamérica desde la década de los ochenta hasta ahora. Explica sus logros en competencias y recursos mayores para los gobiernos locales y la emergencia del paradigma del “buen gobierno local”, con una gestión más participativa. No obstante, el proceso se ha detenido antes de consolidar cambios de fondo en la distribución del poder. La súbita aparición de la crisis mundial crea un nuevo escenario, donde podrían renacer las tendencias concentradoras de los gobiernos centrales. Se propone aprovechar la difícil coyuntura actual para generar alternativas al modelo de crecimiento globalizado, mitigando sus rasgos depredadores y poco democráticos. Los municipios y sus asociaciones tienen mucho que aportar con sus experiencias de buen gobierno en la promoción del desarrollo endógeno. Para ello, hay que potenciar al movimiento asociativo municipal y construir alianzas con otros actores públicos y privados favorables a la democratización y al desarrollo local sustentable. This text analyzes the process of political decentralization developed in Latin America since the eighties up to now. It explains its achievements in competences and greater resources for local governments and the emergency of the paradigm of the “good local government”, with a more participatory management. Nevertheless, the process itself the process has stopped before consolidating deeper changes in the distribution of power. The sudden emergence of the world crisis creates a new setting, where concentration tendencies of central governments could uprise. The proposal is to take advantage of the difficult present situation to generate alternatives to the model of globalized growth, mitigating its predatory and undemocratic characteristics. The municipalities and their associations have a lot that to contribute with their experiences of good government in the promotion of endogenous development. For thus, one must promote the municipal associative movement and build alliances with other private and public actors who favour democratization and sustainable local development.
- Published
- 2012
12. Evolução clínica e radiológica no tratamento da hérnia discal com prótese PDN-SOLO com ancora: seguimento mínimo por três anos
- Author
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Reyes-Sánchez, Alejandro Antonio, Arriada, Nicasio, Miramontes M., Víctor, Alpizar A., Armando, and Rosales O., Luis M.
- Subjects
Prótese articular ,Joint prosthesis ,Deslocamento do disco intervertebral ,Desplazamiento del disco intervertebral ,Prótesis articulares ,Intervertebral disk displacement ,Biomechanics ,Biomecánica ,Biomecânica - Abstract
OBJETIVO: las prótesis de núcleo (PDN-SOLO) reconstruyen la anatomía y preservan la biomecánica del disco intervertebral con un índice de migración de 10% y de hundimiento de 19%. Por eso, proponemos un sistema de fijación para evitar estas complicaciones. MÉTODOS: fueron utilizados veinte pacientes con seguimiento mínimo de tres años. La valoración de dolor con EVA, función con Escala de Oswestry (EO) y disco por estudios radiográficos y resonancia magnética fueron aplicadas. El análisis estadístico fue por t de Student. RESULTADOS: El grupo comprende 8 mujeres y 12 hombres con una edad promedio de 37.6 años. Los valores preoperatorios de EVA fueron 7.6 puntos y EO de 67%, la altura del espacio intervertebral (El) de 7.67 mm. A tres años, EVA de dolor de 0.7 y EO a menos de 6% (p
- Published
- 2010
13. Descentralización del Estado, crisis económica mundial y oportunidades locales en América Latina
- Author
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Rosales O, Mario
- Subjects
gobiernos locales ,political descentralization ,crisis mundial ,Latinoamérica ,descentralización política ,local governments ,world crisis ,Latin-america - Abstract
Este texto analiza el proceso de descentralización política desarrollado en Latinoamérica desde la década de los ochenta hasta ahora. Explica sus logros en competencias y recursos mayores para los gobiernos locales y la emergencia del paradigma del "buen gobierno local", con una gestión más participativa. No obstante, el proceso se ha detenido antes de consolidar cambios de fondo en la distribución del poder. La súbita aparición de la crisis mundial crea un nuevo escenario, donde podrían renacer las tendencias concentradoras de los gobiernos centrales. Se propone aprovechar la difícil coyuntura actual para generar alternativas al modelo de crecimiento globalizado, mitigando sus rasgos depredadores y poco democráticos. Los municipios y sus asociaciones tienen mucho que aportar con sus experiencias de buen gobierno en la promoción del desarrollo endógeno. Para ello, hay que potenciar al movimiento asociativo municipal y construir alianzas con otros actores públicos y privados favorables a la democratización y al desarrollo local sustentable. This text analyzes the process of political decentralization developed in Latin America since the eighties up to now. It explains its achievements in competences and greater resources for local governments and the emergency of the paradigm of the "good local government", with a more participatory management. Nevertheless, the process itself the process has stopped before consolidating deeper changes in the distribution of power. The sudden emergence of the world crisis creates a new setting, where concentration tendencies of central governments could uprise. The proposal is to take advantage of the difficult present situation to generate alternatives to the model of globalized growth, mitigating its predatory and undemocratic characteristics. The municipalities and their associations have a lot that to contribute with their experiences of good government in the promotion of endogenous development. For thus, one must promote the municipal associative movement and build alliances with other private and public actors who favour democratization and sustainable local development.
- Published
- 2009
14. New agents/targets for chronic antithrombotic interventions
- Author
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GOLINO, Paolo, ROSALES O., Golino, Paolo, and Rosales, O.
- Published
- 1995
15. Proteasome activity and proteasome subunit transcripts in human spermatozoa separated by a discontinuous Percoll gradient
- Author
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Rosales, O., primary, Opazo, C., additional, Diaz, E. S., additional, Villegas, J. V., additional, Sanchez, R., additional, and Morales, P., additional
- Published
- 2010
- Full Text
- View/download PDF
16. Evolución clínica y radiológica en el tratamiento de hernia discal con prótesis PDN-SOLO con ancla: seguimiento mínimo a tres años
- Author
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Reyes-Sánchez, Alejandro Antonio, primary, Arriada, Nicasio, additional, Miramontes M., Víctor, additional, Alpizar A., Armando, additional, and Rosales O., Luis M., additional
- Published
- 2010
- Full Text
- View/download PDF
17. Early Predictors of Mortality in Elderly Burn Patients
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Schulman, C I., primary, Namias, N, additional, Varas, R P., additional, Quintana, O D., additional, Rosales, O, additional, Pizano, L R., additional, and Ward, C G., additional
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- 2006
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18. Hypothermia After Cardiac Arrest
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Felberg, R.A., primary, Krieger, D.W., additional, Chuang, R., additional, Persse, D.E., additional, Burgin, W.S., additional, Hickenbottom, S.L., additional, Morgenstern, L.B., additional, Rosales, O., additional, and Grotta, J.C., additional
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- 2001
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19. Adenosine use during aortocoronary vein graft interventions reverses but does not prevent the slow-no reflow phenomenon
- Author
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Sdringola, S., primary, Assali, A., additional, Ghani, M., additional, Yepes, A., additional, Rosales, O., additional, Schroth, G.W., additional, Fujise, Ken, additional, Anderson, H.V., additional, and Smalling, R.W., additional
- Published
- 2000
- Full Text
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20. Primary Angioplasty Improves Outcome in Right Ventricular Infarction
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Rosales, O, primary
- Published
- 1998
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21. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain
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Evans, L., primary, Frenkel, L., additional, Brophy, C. M., additional, Rosales, O., additional, Sudhaker, C. B., additional, Li, G., additional, Du, W., additional, and Sumpio, B. E., additional
- Published
- 1997
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22. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
- Author
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Brophy, C.M., primary, Mills, I., additional, Rosales, O., additional, Isales, C., additional, and Sumpio, B.E., additional
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- 1993
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23. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells
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Rosales, O. R., primary and Sumpio, B. E., additional
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- 1992
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24. Análisis de publicaciones de fracturas toracolumbares que requirieron tratamiento quirúrgico por vía anterior.
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Reyes Sánchez, Alejandro A., Murga Ruiz, Rubén, Rosales O., Luis M., Miramontes M., Víctor, and Alpizar Aguirre, Armando
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TREATMENT of fractures ,LUMBAR vertebrae ,THORACIC vertebrae injuries ,VERTEBRAE ,FRACTURE fixation ,SURGERY ,WOUNDS & injuries - Abstract
Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2003
25. Revascularization in the 21st century.
- Author
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Pinkowish MD, Oz MC, Parmley W, and Rosales O
- Abstract
The scope of coronary revascularizatian is changing radically and quickly. Surgery is becoming less invasive and medical treatments mare so--with several implications, not the least being the complementary nature of modern cardiovascular therapies. [ABSTRACT FROM AUTHOR]
- Published
- 2001
26. Ligamentoplastía interespinosa lumbar con corion para el tratamiento de inestabilidad vertebral.
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Reyes-Sanchez, Alejandro, Rivera, Pedro Villanueva, Miramontes M, Victor, and Rosales O, Luis M.
- Published
- 1998
27. Overexpression of protein kinase C a and 1 has distinct effects on bovine aortic endothelial cell growth
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Rosales, O. R., Isales, C. M., and Bhargava, J.
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- 1998
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28. Hallazgo de un vertebrado del Plioceno en la parte superior de la formacion Totora (region de Callapa Altiplano boliviano)
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Martinez, Claude and Rosales, O.
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PALEONTOLOGIE ,PLIOCENE ,STRATIGRAPHIE ,VERTEBRE ,FOSSILE ,DATATION ,FORMATION TOTORA - Published
- 1972
29. Estrogen replacement therapy and outcome of coronary balloon angioplasty in postmenopausal women.
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Abu-Halawa SA, Thompson K, Kirkeeide RL, Vaughn WK, Rosales O, Fujisi K, Schroth G, Smalling R, Anderson HV, Abu-Halawa, S A, Thompson, K, Kirkeeide, R L, Vaughn, W K, Rosales, O, Fujisi, K, Schroth, G, Smalling, R, and Anderson, H V
- Abstract
Estrogen replacement therapy (ERT) in women after menopause is associated with prevention of clinical coronary artery disease. However, few studies have investigated possible benefits from ERT in postmenopausal women undergoing treatment for established coronary disease. We therefore retrospectively reviewed the clinical outcomes of 428 postmenopausal women undergoing percutaneous transluminal coronary balloon angioplasty (PTCA) to test the hypothesis that ERT has a beneficial effect in this setting. The women were divided into 2 groups based on ERT status at the time of the procedure. Estrogen users were younger (60 +/- 10 vs 68 +/- 9 years, p <0.001), more commonly had family histories of coronary heart disease (54% vs 41%, p = 0.04), had less incidence of hypertension (63% vs 76%, p = 0.02), and had slightly fewer diseased vessels per patient (1.3 +/- 0.5 vs 1.5 +/- 0.7, p = 0.03) compared with nonusers. No in-hospital deaths occurred in estrogen users compared with 5% hospital mortality in nonusers (p = 0.01). The combined outcome of death or myocardial infarction (MI) also was lower in estrogen users (4% vs 12%, p = 0.04). Of 348 women discharged after successful PTCA, 336 (97%) were able to be contacted at an average follow-up interval of 22 +/- 17 months (range 5 to 82). Estrogen users had superior event-free survival both for death as well as for death or nonfatal MI. Repeat revascularizations were similar in both groups (32% vs 24%, p = 0.15). In a Cox proportional-hazards model, nonusers had 4 times the likelihood of death after angioplasty compared with estrogen users (OR = 4.025, 95% CI = 1.3 to 13.4, p = 0.02). We conclude that estrogen replacement may offer protection against clinical coronary events in postmenopausal women who already have established coronary disease and are undergoing balloon angioplasty. The benefit was independent of age, smoking, presence of diabetes mellitus, or the number of diseased coronary vessels. However, it did not include a reduction in repeat revascularization procedures, suggesting no reduction in restenosis. [ABSTRACT FROM AUTHOR]
- Published
- 1998
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30. A portable, universal patient positioning and holding system for use in the burn patient: 'The Burnwalter'.
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Schulman CI, Namias BJ, Rosales O, Pizano LR, Ward CG, and Namias N
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A technique is described for the intra-operative positioning of the burn patient, which allows circumferential access without the need for specialized equipment or extra personnel. The equipment is available in any standard operating room and table without the need for redesign or new construction. In addition, it allows full 360 degrees access and eliminates the need for extra personnel to hold proper positioning. This allows for more efficient operating and should minimize the unwanted sequelae of hypothermia and blood loss. Operating time may be decreased and the patient may require less operative procedures. The same or more work can be done by less personnel, in less time, with no added cost. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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31. Causes of early reintervention after successful coronary artery stenting.
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Assali, Abid R., Sdringola, Stefano, Assali, A R, Sdringola, S, Ghani, M, Moustapha, A, Anderson, H V, Schroth, G, Fujise, K, Smalling, R W, and Rosales, O
- Subjects
- *
CORONARY artery surgery , *SURGICAL stents - Abstract
Acute reintervention was performed in 26 of 1,620 patients after coronary stenting (1.6%). Half of the patients had stent thrombosis and the other half residual anatomic problems. The mean time for reintervention was shorter in patients with stent thrombosis. All patients with stent thrombosis had a sudden recurrence of chest pain. Electrocardiographic changes were more common with stent thrombosis. Composite end point occurred in 10 patients (77%) with stent thrombosis versus 5 (39%) in the other group (p = 0.04). [ABSTRACT FROM AUTHOR]
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- 2000
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32. Socioeconomic disparities based on shooting intent in pediatric firearm injury.
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Cain CM, Oluyomi AO, Levine N, Pompeii L, Rosales O, and Naik-Mathuria B
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- Humans, Male, Female, Child, Texas epidemiology, Adolescent, Socioeconomic Factors, Child, Preschool, Firearms statistics & numerical data, Neighborhood Characteristics statistics & numerical data, Infant, Socioeconomic Disparities in Health, Wounds, Gunshot epidemiology
- Abstract
Background: Pediatric firearm injury is often associated with socioeconomically disadvantaged neighborhoods. Most studies only include fatal injuries and do not differentiate by shooting intent. We hypothesized that differences in neighborhood socioeconomic disadvantage would be observed among shooting intents of fatal and nonfatal cases., Methods: A linked integrated database of pediatric fatal and nonfatal firearm injuries was developed from trauma center and medical examiner records in Harris County, Texas (2018-2020). Geospatial analysis was utilized to map victim residence locations, stratified by shooting intent. Area Deprivation Index (ADI), a composite measure of neighborhood socioeconomic disadvantage at the census tract level was linked to shooting intent. Differences in high ADI (more deprived) versus low ADI among the shooting intents were assessed. Unadjusted and adjusted regression models assessed differences in ADI scores across shooting intent, adjusted models controlled for age, gender, and race/ethnicity., Results: Of 324 pediatric firearm injuries, 28% were fatal; 77% were classified as interpersonal violence, 15% unintentional, and 8% self-harm. Differences were noted among shooting intent across the ADI quartiles; with increases in ADI score, the odds of interpersonal violence injuries compared with self-harm injuries significantly increased by 5%; however, when adjusting for individual-level variables of age, gender, and race and ethnicity, no significant differences in ADI were noted., Conclusion: Our results suggest that children living in disadvantaged neighborhoods are more likely to be affected by interpersonal firearm violence compared with self-harm; however, when differences in race/ethnicity are considered, the differences attributable to neighborhood-level disadvantage disappeared. Resources should be dedicated to improving structural aspects of neighborhood disadvantage, which disproportionately impact racial/ethnic minoritized populations. Furthermore, firearm self-harm injuries occurred among children living in the less disadvantaged neighborhoods. Understanding the associations among individual and neighborhood-level factors are important for developing streamlined injury prevention interventions by shooting intent., Level of Evidence: Prognostic and Epidemiological; Level IV., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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33. Awe Inducing Elements in Virtual Reality Applications: A Prospective Study of Hospitalized Children and Caregivers.
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He EM, Arshad F, Li BS, Brinda R, Ganesan A, Zhang L, Fehr S, Renavikar M, Rodriguez ST, Wang E, Rosales O, and Caruso TJ
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Background: Hospitalized pediatric patients and their caregivers often experience anxiety and fear, resulting in withdrawal and aggression. Despite virtual reality (VR) being a safe and effective anxiolytic, it is unknown what software design aspects contribute to its effectiveness. This prospective observational study evaluated which VR application elements increased awe, which is correlated with improved behavior and satisfaction. Methods: Patients aged 6 to 25 years and their caregivers at an academic pediatric hospital interacted with a custom VR application that compared design aspects, including environment, graphics fidelity, and presence of a motivational character. Outcomes investigated self-reported awe, vastness, accommodation, and engagement. Data were analyzed using repeated measure ANOVA tests and correlation analyses. Results: A total of 202 participants were enrolled, and 179 (88 pediatric patients, 91 adult caregivers) were included in the final analysis. A fictional environment was more effective at increasing awe in pediatric patients ( P = 0.030) compared with a realistic environment. However, increased graphics fidelity was more effective at increasing awe in caregiver adults ( P = 0.023) compared with low resolution graphics. Presence of a motivational character did not influence awe in either patients or caregivers ( P = 0.432, P = 0.904, respectively). All measures of awe were positively correlated with application engagement ( P < 0.005). Conclusion: In conclusion, when software developers design VR software for pediatric patients and their caregivers, fictional settings and increased graphic fidelity should be considered for pediatric patients and adults, respectively. Future studies will explore other VR elements in gameplay settings.
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- 2024
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34. Development, Implementation, and Evaluation of Three Outreach Events to Improve COVID-19 Vaccine Uptake Among Racial and Ethnic Minority Communities in Houston, Texas, 2022.
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Munoz-Lavanderos C, Oluyomi A, Rosales O, Hernandez N, Mensah-Bonsu N, and Badr H
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- Humans, Texas, Female, Male, Adult, Vaccination Hesitancy statistics & numerical data, Vaccination Hesitancy psychology, Middle Aged, SARS-CoV-2, Program Evaluation, Community-Institutional Relations, Hispanic or Latino statistics & numerical data, Hispanic or Latino psychology, Black or African American statistics & numerical data, COVID-19 Vaccines administration & dosage, COVID-19 prevention & control, COVID-19 ethnology, Ethnic and Racial Minorities statistics & numerical data
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Objectives: Lack of access to timely, accurate, and linguistically appropriate COVID-19 information has complicated the dissemination of evidence-based information and contributed to vaccine hesitancy among racial and ethnic minority groups in the United States. We developed community events that provided outreach, education, and access to COVID-19 vaccination to overcome vaccine hesitancy in these communities., Methods: Using spatial analysis techniques, we identified 3 communities with low vaccine uptake in Houston, Texas, in fall 2021; engaged 20 stakeholders from these communities via 4 focus groups to understand barriers to vaccination; and developed and implemented 3 COVID-19 vaccine education and outreach events tailored to the needs of these communities in January-March 2022. We used program evaluation surveys to assess attendee characteristics and satisfaction with the events. Vaccinated attendees also completed surveys on what motivated them to get vaccinated., Results: Two communities were predominantly Hispanic, and the third had an equal number of Black and Hispanic residents. Based on community stakeholder input, the study team organized 2 health fairs and 1 community festival featuring dialogue-based COVID-19 vaccine engagement in January and March 2022. Across the 3 events, a total of 865 attendees received COVID-19 education and 205 (24.0%) attendees received a COVID-19 vaccine or booster. Of 90 attendees who completed program evaluation surveys, 81 (90%) rated the outreach event as good or excellent. Of 145 attendees who completed postvaccination surveys, 132 (91%) endorsed ≥1 key program feature as motivating them to either get vaccinated or vaccinate their child that day., Conclusion: Community outreach events are important strategies for disseminating information, building trust, and facilitating COVID-19 vaccine uptake., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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35. Residential proximity to oil and gas developments and childhood cancer survival.
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Hoang TT, Rathod RA, Rosales O, Castellanos MI, Schraw JM, Burgess E, Peckham-Gregory EC, Oluyomi AO, Scheurer ME, Hughes AE, and Lupo PJ
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Background: Environmental toxicants may impact survival in children with cancer, but the literature investigating these associations remains limited. Because oil and gas developments emit several hazardous air pollutants, the authors evaluated the relationship between residential proximity to oil or gas development and survival across 21 different pediatric cancers., Methods: The Texas Cancer Registry had 29,730 children (≤19 years old) diagnosed with a primary cancer between 1995 to 2017. Geocoded data were available for 285,266 active oil or gas wells and 109,965 horizontal wells. The authors calculated whether each case lived within 1000 m (yes/no) from each type of oil or gas development. Survival analyses were conducted using Cox regression, adjusting for potential confounders., Results: A total of 14.2% of cases lived within 1000 m of an oil or gas well or horizontal well. Living within 1000 m of an oil or gas well was associated with risk of mortality in cases with acute myeloid leukemia (AML) (adjusted hazard ratio [aHR], 1.36; 95% confidence interval [CI], 1.01-1.84) and hepatoblastoma (aHR, 2.13; 95% CI, 1.03-4.39). An inverse association was observed with Ewing sarcoma (aHR, 0.35; 95% CI, 0.13-0.95). No associations were observed with horizontal well. There was evidence of a dose-response effect in children with AML or hepatoblastoma and residential proximity to oil or gas wells. In general, the magnitude of association increased with decreasing distance and with higher number of wells across the three distances., Conclusions: Residential proximity to oil or gas wells at diagnosis is associated with the risk of mortality in children with AML or hepatoblastoma., (© 2024 American Cancer Society.)
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- 2024
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36. Virtual Reality Facilitated Exercise Increases Sympathetic Activity and Reduces Pain Perception: A Randomized Crossover Study.
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Rodriguez ST, Makarewicz N, Wang EY, Zuniga-Hernandez M, Titzler J, Jackson C, Suen MY, Rosales O, and Caruso TJ
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Objective: Both virtual reality (VR) and exercise reduce pain while avoiding the risks of traditional pharmacotherapy. The aim of this study was to assess how VR-facilitated exercise modulates sympathetic activity and pain perception., Design: Healthy adult volunteers were randomized by hand dominance and then subjected to a standardized cold pressor test while experiencing a VR application. After a 5-minute washout, participants were crossed-over and repeated the test on their other hand while undergoing a VR-facilitated exercise application. Sympathetic activation, pain sensation, and pain tolerance data were collected identically during both conditions., Results: 110 participants were analyzed. Sympathetic activity increased in both conditions but was higher in the VR-facilitated exercise condition (p < 0.0001). Pain sensation scores were initially higher with VR-facilitated exercise but dropped below the VR-only condition by the end of the intervention (p = 0.0175). There were no differences in pain tolerance between conditions (p = 0.18)., Conclusion: The decrease in pain perception with VR-facilitated exercise condition compared to VR alone indicates VR-facilitated exercise can be a useful tool for managing pain. Though this effect did not translate into higher pain tolerance, VR-facilitated exercise may be a useful intervention in the setting of physical therapy or for patients with chronic pain., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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37. Experiences of using the MINDSET Self-Management mobile health app among Hispanic Patients:Results of a qualitative study.
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Sepulveda R, Chong J, Shegog R, Martin K, Begley C, Addy R, Rosales O, Nuño T, Soto S, Rosales C, and Labiner D
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- Adult, Humans, Female, Male, Quality of Life, Seizures, Hispanic or Latino, Self-Management, Mobile Applications, Epilepsy therapy, Telemedicine
- Abstract
Background: Interventions focusing on epilepsy self-management (ESM) are vital for promoting the health of people living with epilepsy. E-technology and mobile health (mHealth) tools are becoming increasingly integrated into practice to promote self-management strategies for chronic diseases, enhance care delivery, and reduce health disparities. Management Information and Decision Support Epilepsy Tool (MINDSET), a bilingual decision support tool (available in English and Spanish), was found to be both feasible and effective in facilitating goal-based ESM in the clinic., Purpose: To assess the experience of using MINDSET as an ESM intervention among Hispanic patients with epilepsy to inform future interventional studies., Methods: This study used a Qualitative Descriptive (QD) framework to provide a rich and straightforward description of patients' subjective experiences using MINDSET. Participants were enrolled in the intervention group of a larger parent study (RCT) to assess the efficacy of MINDSET among Hispanic People with Epilepsy (PWE). The purposive, convenient, criterion-based sample for this qualitative analysis comprised of 42 patients who agreed to participate in a semi-structured interview at the end of the larger RCT. This RCT was conducted between August 2017 and January 2019. Spanish and English-speaking Hispanic adult patients (n = 94) with epilepsy in Arizona (n = 53) and Texas (n = 41) were randomly assigned within 6 neurology clinics to treatment (MINDSET plus Usual Care, hereafter referred to as MINDSET; n = 46) and comparison (Usual Care Only; n = 48) conditions., Results: Patient demographics, epilepsy conditions, and ESM behavioral characteristics were representative of the intervention group. Study participants were Hispanic, mainly of Mexican descent (94 %), with a mean age of 39 years, mostly female (53 %), and most of the participants reported having had one or more seizures per month (54 %). The MINDSET intervention revealed five ESM themes: (1) Awareness and Realization of Epilepsy Self-Management, (2) Communication and Partnership with Health Care Providers HCP, (3) Epilepsy Self-Management and Quality of Life, (4) Seizure Control, and (5) Optimism and Agency., Conclusion: The participants who used MINDSET as a self-management intervention reported an overall positive experience. Qualitative data in this study show that MINDSET is a valuable ESM tool for Hispanic patients with epilepsy. Findings from this qualitative study were consistent with results from a larger parent study that recognized MINDSET as an effective platform for improving epilepsy self-management adherence., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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38. The Use of Telemedicine by US Nephrologists for In-Center Hemodialysis Care During the Pandemic: An Analysis of National Medicare Claims.
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Niu J, Rosales O, Oluyomi A, Lew SQ, Winkelmayer WC, Chertow GM, and Erickson KF
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Rationale & Objective: Because of coronavirus disease 2019 (COVID-19), the US government issued emergency waivers in March 2020 that removed regulatory barriers around the use of telemedicine. For the first time, nephrologists were reimbursed for telemedicine care delivered during in-center hemodialysis. We examined the use of telemedicine for in-center hemodialysis during the first 16 months of the pandemic., Study Design: We ascertained telemedicine modifiers on nephrologist claims. We used multivariable regression to examine time trends and patient, dialysis facility, and geographic correlates of telemedicine use. We also examined whether the estimated effects of predictors of telemedicine use changed over time., Setting & Participants: US Medicare beneficiaries receiving in-center hemodialysis between March 1, 2020, and June 30, 2021., Exposures: Patient, geographic, and dialysis facility characteristics., Outcomes: The use of telehealth for in-center hemodialysis care., Analytic Approach: Retrospective cohort analysis., Results: Among 267,434 Medicare beneficiaries identified, the reported use of telemedicine peaked at 9% of patient-months in April 2020 and declined to 2% of patient-months by June 2021. Telemedicine use varied geographically and was more common in areas that were remote and socioeconomically disadvantaged. Patients were more likely to receive care by telemedicine in areas with higher incidence of COVID-19, although the predictive value of COVID-19 diminished later in the pandemic. Patients were more likely to receive care using telemedicine if they were at facilities with more staff, and the use of telemedicine varied by facility ownership type., Limitations: Limited reporting of telemedicine on claims could lead to underestimation of its use. Reported telemedicine use was higher in an analysis designed to address this limitation by focusing on patients whose physicians used telemedicine at least once during the pandemic., Conclusions: Some US nephrologists continued to use telemedicine for in-center hemodialysis throughout the pandemic, even as the association between COVID-19 incidence and telemedicine use diminished over time. These findings highlight unique challenges and opportunities to the future use of telemedicine in dialysis care., (© 2024 The Authors.)
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- 2024
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39. Feasibility and Acceptability of Home-Delivered Medically Tailored Meals for Treatment of Diabetes in Pregnancy.
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Huang TS, Rosales O, Durnwald CP, and Dolin CD
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- Pregnancy, Female, Humans, United States, Prospective Studies, Feasibility Studies, Meals, Diabetes Mellitus, Nutrition Therapy
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Background: Diabetes complicates ≤7% of pregnancies in the United States. Although medical nutrition therapy is the mainstay of diabetes treatment, many barriers exist to the successful implementation of dietary modifications. Home-delivered medically tailored meals (MTMs) are promising to overcome such barriers., Objective: The objective of this study was to evaluate the feasibility and acceptability of home-delivered MTM in pregnant patients with diabetes., Methods: We performed a prospective cohort study of home-delivered MTM for pregnant patients with diabetes using a mixed-methods approach. Participants <35 wk of gestation at the time of enrollment received weekly home delivery of diabetes-specific meals. Qualitative semistructured interviews were conducted to gain insight into participants' experience. Diabetes self-efficacy was assessed pre- and postintervention using the Diabetes Self-Efficacy Scale and 2-Item Diabetes Distress Screening Scale. The difference in mean scores was compared using t-tests with P value of <0.05 considered significant. Feasibility and acceptability were evaluated through participants' attitude toward MTM in qualitative interviews and indirectly evaluated through diabetes self-efficacy surveys., Results: Twenty pregnant people with diabetes who received home-delivered MTM during pregnancy were interviewed postpartum. Participants found this program convenient for various reasons, including reduced time for grocery shopping and preparing meals. Participants were satisfied with meals, citing a positive impact on diabetes management, accessibility of healthy foods, reduced stress with meal planning, and greater perceived control of blood glucose. Most participants shared meals with their families or received specific meals for their dependents, which was positively received. Reduced financial and mental stress was also widely reported. Diabetes self-efficacy was significantly improved postintervention with MTM., Conclusion: Home-delivered MTM is feasible and acceptable in pregnant patients with diabetes and may improve diabetes self-efficacy. Individual experiences offered insight into various barriers overcome by using this service. Home-delivered MTM may help ensure an accessible, healthy diet for pregnant patients with diabetes., (Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.)
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- 2024
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40. Prehospital Pediatric Emergency Training Using Augmented Reality Simulation: A Prospective, Mixed Methods Study.
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Friedman N, Zuniga-Hernandez M, Titzler J, Suen MY, Wang E, Rosales O, Graham J, D'Souza P, Menendez M, and Caruso TJ
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- Humans, Child, Prospective Studies, Computer Simulation, Augmented Reality, Emergency Medical Services, Emergency Medical Technicians, Simulation Training methods
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Objective: Pediatric emergencies are high-stakes yet low-volume clinical encounters for emergency medical services (EMS) clinicians, necessitating innovative approaches to training. We sought to explore the acceptability, usability, and ergonomics of a novel augmented reality (AR) software for EMS crisis management training., Methods: This was a prospective, mixed-methods study employing qualitative and quantitative analyses. We enrolled emergency medical technicians (EMTs) and paramedics at a municipal fire service in Northern California. We ran the Chariot Augmented Reality Medical simulation software (Stanford Chariot Program, Stanford University, Stanford, CA) on the ML1 headset (Magic Leap, Inc., Plantation, FL), which enabled participants to view an AR image of a patient overlaid with real-world training objects. Participants completed a simulation of a pediatric hypoglycemia-induced seizure and cardiac arrest. Participants subsequently engaged in structured focus group interviews assessing acceptability, which we coded and thematically analyzed. We evaluated the usability of the AR system and ergonomics of the ML1 headset using previously validated scales, and we analyzed findings with descriptive statistics., Results: Twenty-two EMS clinicians participated. We categorized focus group interview statements into seven domains after an iterative thematic analysis: general appraisal, realism, learning efficacy, mixed reality feasibility, technology acceptance, software optimization, and alternate use cases. Participants valued the realism and the mixed reality functionality of the training simulation. They reported that AR could be effective for practicing pediatric clinical algorithms and task prioritization, building verbal communication skills, and promoting stress indoctrination. However, participants also noted challenges with integrating AR images with real-world objects, the learning curve required to adapt to the technology, and areas for software improvement. Participants favorably evaluated the ease of use of the technology and comfortability of wearing the hardware; however, most participants reported that they would need technical support., Conclusion: Participants positively evaluated the acceptability, usability, and ergonomics of an AR simulator for pediatric emergency management training, and participants identified current technological limitations and areas for improvement. AR simulation may serve as an effective training adjunct for prehospital clinicians.
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- 2024
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41. Facility Closures and Distance Traveled to Receive Dialysis Care in the United States.
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Niu J, Worsley M, Rosales O, Oluyomi A, and Erickson KF
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- Humans, United States, Health Services Accessibility, Travel, Renal Dialysis, Peritoneal Dialysis
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- 2023
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42. Virtual reality facilitated exercise improves pain perception: A crossover study.
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Rodriguez ST, Makarewicz N, Wang EY, Zuniga-Hernandez M, Titzler J, Jackson C, Suen MY, Rosales O, and Caruso TJ
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Study Objective: Both virtual reality (VR) and exercise are recognized for their analgesic and anxiolytic properties. The purpose of this study is to evaluate the ability of VR-facilitated exercise to modulate pain., Design: Within-subject cross-over clinical trial., Setting: The Stanford Chariot Program conducted this study at Lucile Packard Children's Hospital Stanford (LCPHS)., Patients: Healthy participants meeting inclusion criteria were recruited by volunteer solicitation from LCPHS., Interventions: Participants were randomized by hand dominance and subjected to a standardized cold pressor test with no VR or exercise. After a 5-min wash-out period, participants repeated the test on their other hand while experiencing a VR-facilitated exercise condition. Pain sensitivity, pain tolerance, and sympathetic activation data were collected during both conditions., Measurements: Pain sensitivity was scored 0-10 and collected every 30 s. Pain tolerance was recorded as the duration a participant could endure the painful stimuli. Sympathetic activation was measured by skin conductance response density (SCRD) and recorded in 30 s epochs by a biosensor. In all analyses, data were nested by participant., Main Results: Forty-one participants completed both interventions. Pain sensitivity was reduced in the VR-facilitated exercise condition (p < 0.0001). There was no difference in pain tolerance between conditions. While both conditions resulted in an increase in sympathetic activity, SCRD was higher at all time points in the VR-facilitated exercise condition., Conclusions: The reduction in pain sensitivity indicates VR-facilitated exercise results in improved pain perception. VR-facilitated exercise may be especially useful for patients with chronic pain or other conditions requiring physical therapy, where pain may be exacerbated by exercise., Competing Interests: Declaration of Competing Interest Authors SR, EW, and TC are on the board of a nonprofit (Invincikids, Inc), that seeks to distribute immersive technology to hospitalized children at no cost. The Stanford Chariot Program has received philanthropic donations from Meta Inc., and Magic Leap, Inc. SR received consultation fees from Apple, Inc. All other authors declare no competing interests or conflicts of interest., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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43. Clustering of Pediatric Brain Tumors in Texas, 2000-2017.
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Hoang TT, Rosales O, Burgess E, Lupo PJ, Scheurer ME, and Oluyomi AO
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Risk factors for pediatric brain tumors are largely unknown. Identifying spatial clusters of these rare tumors on the basis of residential address may provide insights into childhood socio-environmental factors that increase susceptibility. From 2000-2017, the Texas Cancer Registry recorded 4305 primary brain tumors diagnosed among children (≤19 years old). We performed a spatial analysis in SaTScan to identify neighborhoods (census tracts) where the observed number of pediatric brain tumors was higher than expected. Within each census tract, the number of pediatric brain tumors was summed on the basis of residential address at diagnosis. The population estimate from the 2007-2011 American Community Survey of 0- to 19-year-olds was used as the at-risk population. p -values were calculated using Monte Carlo hypothesis testing. The age-standardized rate was 54.3 per 1,000,000. SaTScan identified twenty clusters, of which two were statistically significant ( p < 0.05). Some of the clusters identified in Texas spatially implicated potential sources of environmental risk factors (e.g., proximity to petroleum production processes) to explore in future research. This work provides hypothesis-generating data for further investigations of spatially relevant risk factors of pediatric brain tumors in Texas.
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- 2023
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44. Trends in Up-To-Date Colorectal Cancer Screening Among U.S. Adults Aged 50-75 Years and Variations by Race/Ethnicity and U.S. Census Bureau Divisions.
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Sokale IO, Rosales O, Montealegre JR, Oluyomi AO, and Thrift AP
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Introduction: Mortality rates from colorectal cancer have declined over the past decades owing to population-based life-saving screening interventions. However, screening inequalities continue among racial and ethnic minorities despite having a higher disease burden. In this study, we assessed the patterns of up-to-date colorectal cancer screening rates among racial/ethnic groups across the U.S. Census Bureau Divisions., Methods: This population-based cross-sectional study used weighted data from 4 cycles of the Behavioral Risk Factors Surveillance System (2014, 2016, 2018, and 2020) of adults aged 50‒75 years without a previous diagnosis of colorectal cancer. The primary outcome was guideline-recommended up-to-date colorectal cancer screening. We used logistic regression models to examine temporal trends in up-to-date colorectal cancer screening from 2014 to 2020. In addition, we conducted detailed descriptive statistics of up-to-date screening rates, comparing trends in 2020 with those in 2014 overall by race/ethnicity and U.S. census divisions., Results: The overall proportion of individuals with up-to-date colorectal cancer screening increased from 66.5% in 2014 to 72.5% in 2020 ( p <0.001). For racial/ethnic subgroups, from 2014 to 2020, screening rates increased significantly among non-Hispanic Whites (68.5%‒74.5%, p <0.001), non-Hispanic Blacks (68.0%‒74.6%, p <0.001), and Hispanics (51.5%‒62.8%, p <0.001). However, increases were not observed in all U.S. Census Bureau Divisions., Conclusions: Although colorectal cancer screening rates improved over time, they fall short of the 80% target. Substantial racial/ethnic and geographic disparities remain. Future studies investigating the factors influencing these disparities are needed., Competing Interests: None., (© 2022 The Authors.)
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- 2022
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45. Patterns of venous thromboembolism risk, treatment, and outcomes among patients with cancer from uninsured and vulnerable populations.
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da Costa WL Jr, Guffey D, Oluyomi A, Bandyo R, Rosales O, Wallace CD, Granada C, Riaz N, Fitzgerald M, Garcia DA, Carrier M, Amos CI, Flowers CR, and Li A
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- Humans, Incidence, Medically Uninsured, Retrospective Studies, Risk Factors, Vulnerable Populations, Neoplasms complications, Neoplasms epidemiology, Neoplasms therapy, Pulmonary Embolism etiology, Venous Thromboembolism drug therapy, Venous Thromboembolism epidemiology, Venous Thromboembolism etiology
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The epidemiology of cancer-associated thrombosis (CAT) among uninsured and vulnerable populations in the US is not well-characterized. We performed a retrospective cohort study for patients with newly diagnosed cancer from 2011 to 2020 at Harris Health System, which cares for uninsured residents in the Houston metropolitan area. Patient demographics, NCI comorbidity index, area of deprivation index (ADI), cancer histology, staging, and systemic therapy data were extracted. CAT included overall venous thromboembolism (VTE) or pulmonary embolism +/- lower extremity deep vein thrombosis (PE/LE-DVT) within 1 year of diagnosis. We used multivariable Fine-Gray models to assess the associations with CAT accounting for death as a competing risk. Among 15 342 patients, 74% were uninsured and 84% lived in socioeconomically disadvantaged neighborhoods. There were 16% Non-Hispanic White (NHW), 28% Non-Hispanic Black (NHB), 50% Hispanic (27% Mexican), and 6% Asian/Pacific Islanders (API). The 1-year CAT incidence rate was 14.6%. Overall VTE was lower for Hispanics versus NHW (SHR 0.87 [0.76-0.99]) and API versus NHW (SHR 0.58 [0.44-0.77]). PE/LE-DVT was higher for NHB versus NHW (SHR 1.18 [1.01-1.39]). CAT was also associated with chemotherapy-based regimens (+/- immunotherapy), age, obesity, cancer type/staging, VTE history, and recent hospitalization. NCI comorbidity and ADI scores were associated with mortality but not CAT. In a large cohort of underserved patients with cancer, we identified an elevated incidence of CAT with known and novel risk predictors. Hispanics had lower adjusted rates of CAT and mortality. Our findings highlight the need to investigate and incorporate vulnerable populations in clinical trials., (© 2022 Wiley Periodicals LLC.)
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- 2022
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46. COVID-19 Vaccine Uptake among US Adults According to Standard Occupational Groups.
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Sokale I, Alvarez J, Rosales O, Bakota E, Amos CI, Badr H, and Oluyomi AO
- Abstract
This cross-sectional ecological study examined the relationship between neighborhood-level standard occupational groups in the USA and COVID-19 vaccine uptake using 774 census tract data, each consisting of approximately 1600 housing units. The neighborhood-level COVID-19 vaccination uptake data were retrieved from Harris County Public Health, Harris County, Texas. The standard occupational group data were from the US Census Bureau. We calculated the incidence rate ratios (IRRs) for vaccine uptake using bivariate and multivariable Poisson regression models. In the adjusted models, we found that the healthcare practitioner/technician (IRR: 1.008; 95% CI: 1.003−1.014; p = 0.001), business/management/legal (IRR: 1.011; 95% CI: 1.008−1.013; p < 0.001), computer/engineering/life/physical/social science (IRR: 1.018; 95% CI: 1.013−1.023; p < 0.001), and arts/design/entertainment/sports/media (IRR: 1.031; 95% CI: 1.018−1.044; p < 0.001) occupational groups were more likely to have received the full regimen of a COVID-19 vaccine. On the contrary, the building/installation/maintenance/repair (IRR: 0.991; 95% CI: 0.987−0.995; p < 0.001), construction/extraction/production (IRR: 0.991; 95% CI: 0.988−0.995; p < 0.001), transportation/material moving (IRR: 0.992; 95% CI: 0.987−0.997; p = 0.002), food preparation/serving related (IRR: 0.995; 95% CI: 0.990−0.999; p = 0.023), and personal care/services (IRR: 0.991; 95% CI: 0.985−0.998; p = 0.017) groups were less likely to have received the complete dose of a COVID-19 vaccine. White-collar workers were more likely to be vaccinated than blue-collar workers. We adjusted for age, sex, and race/ethnicity in the multivariable analysis. The low vaccine uptake among certain occupational groups remains a barrier to pandemic control. Engaging labor-centered stakeholders in the development of vaccination interventions may increase uptake.
- Published
- 2022
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47. Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital.
- Author
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Soto A, Quiñones-Laveriano DM, Azañero J, Chumpitaz R, Claros J, Salazar L, Rosales O, Nuñez L, Roca D, and Alcantara A
- Subjects
- Adult, Aged, COVID-19 epidemiology, COVID-19 pathology, COVID-19 therapy, Cohort Studies, Comorbidity, Female, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Peru epidemiology, Referral and Consultation statistics & numerical data, Retrospective Studies, Risk Factors, SARS-CoV-2 physiology, COVID-19 mortality, Hospital Mortality
- Abstract
Objectives: To determine the risk factors for in-hospital mortality in patients with COVID-19 from a Peruvian national hospital., Methods: Retrospective cohort study of medical records of patients with COVID-19 hospitalized at Hospital Nacional Hipólito Unanue (HNHU) during the months of April to August 2020. The dependent variable was in-hospital mortality. Independent variables included sociodemographic and clinical characteristics, physical examination findings, oxygen saturation (SaO2) at admission, treatment received during hospitalization and laboratory results at admission. A Cox regression model was used to evaluate the crude and adjusted hazard ratios for associated factors., Results: We included 1418 patients. Median age was 58 years (IQR 47-68 years) and 944 (66.6%) were male. The median length of hospitalization was 7 (4-13) days, and the mortality rate was 46%. The most frequent comorbidities were type 2 diabetes mellitus, hypertension, and obesity. In the adjusted analysis, mortality was associated with age (HR 1.02; 95%CI 1.02-1.03), history of surgery (HR 1.89; 95%CI 1.31-2.74), lower oxygen saturation at admission (HR 4.08; CI95% 2.72-8.05 for SaO2<70% compared to SaO2>94%), the presence of poor general condition (HR 1.81; 95% CI 1.29-2.53), altered state of consciousness (HR 1.58; 95%CI 1.18-2.11) and leukocyte levels (HR 1.01; 95%CI 1.00-1. 02). Treatment with ivermectin (HR 1.44; 95%CI 1.18-1.76) and azithromycin (HR 1.25; 95%CI 1.03-1.52) were associated with higher mortality. Treatment with corticosteroids at low to moderate doses was associated with lower mortality (HR 0.56 95%CI 0. 37-0. 86) in comparison to no steroid use., Conclusion: A high mortality was found in our cohort. Low oxygen saturation at admission, age, and the presence of hematological and biochemical alterations were associated with higher mortality. The use of hydroxychloroquine, ivermectin or azithromycin was not useful and was probably associated with unfavorable outcomes. The use of corticosteroids at moderate doses was associated with lower mortality., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
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48. Depression and suicidality among Hispanics with epilepsy: Findings from the Managing Epilepsy Well (MEW) Network integrated database.
- Author
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O'Kula SS, Briggs FBS, Brownrigg B, Sarna K, Rosales O, Shegog R, Fraser RT, Johnson EK, Quarells RC, Friedman D, Sajatovic M, and Spruill TM
- Subjects
- Adult, Cross-Sectional Studies, Depression epidemiology, Humans, Suicidal Ideation, Epilepsy epidemiology, Suicide
- Abstract
Objective: Although psychiatric disorders are more common among people with epilepsy,
2 depression and suicidal ideation among Hispanics with epilepsy remain understudied. We examined the prevalence and correlates of depression and suicidal ideation among Hispanic adults with epilepsy who participated in self-management studies in the Managing Epilepsy Well3 Network., Methods: This cross-sectional analysis of pooled data from ten studies used the Patient Health Questionnaire-94 or Neurological Disease Depression Inventory-Epilepsy5 to examine the prevalence of elevated depressive symptoms (PHQ ≥ 10, NDDI-E ≥ 15) and suicidal ideation (PHQ-9 item 9 ≥ 1, NDDI-E item 4 ≥ 2). Multilevel mixed-effects logistic regression models examined associations between ethnicity, elevated depressive symptoms, and suicidal ideation among PWE. Secondary analyses examined correlates of elevated depressive symptoms and suicidal ideation among Hispanic PWE., Results: Of 559 participants, 49.6% (n = 277) were Hispanic. Elevated depressive symptoms were endorsed by 38.1% (n = 213) of all participants (32.5% of Hispanics); suicidal ideation was endorsed by 18.4% (n = 103) of all participants (16.3% of Hispanics). After adjustment for sociodemographic and health attributes, Hispanic PWE had a 44% lower prevalence of elevated depressive symptoms (OR = 0.56, CI 0.37-0.84, p = 0.0056) compared to non-Hispanics but similar rates of suicidal ideation (OR = 0.84, CI 0.45-1.58, p = 0.59). Acculturation measures were available for 256 (92.4%) of Hispanic PWE: language preference was Spanish for 62.9%, 46.1% were foreign-born. Spanish-speaking Hispanics were less likely than English-speaking Hispanics to report elevated depressive symptoms (OR = 0.43, CI 0.19-0.97, p = 0.041); however, Hispanics who reported fair or poor health status had a four-fold higher depression prevalence compared to those who reported excellent or very good health status [reference group] (OR = 4.44, CI 1.50-13.18, p = 0.0071). Of the Hispanics who provided prior 30-day seizure data, ≥1 monthly seizure was independently associated with higher depression prevalence (OR = 3.11, CI 1.29-7.45, p = 0.01). Being foreign-born was not associated with elevated depressive symptoms or suicidal ideation prevalence., Conclusions: In a large, geographically diverse sample of PWE, elevated depressive symptoms were significantly lower in Hispanics compared to non-Hispanics. Spanish language preference was associated with a lower prevalence of elevated depressive symptoms among Hispanic PWE. Future studies should include acculturation data to better screen for depression and suicidal ideation risk and optimize interventions for Hispanic PWE., Competing Interests: Declaration of Competing Interest Susanna S. O’Kula, Farren B.S. Briggs, Brittany Brownrigg, Kaylee Sarna, Omar Rosales, Ross Shegog, Erica K. Johnson, Robert T. Fraser, Rakale Quarells, and Tanya M. Spruill have no conflicts of interest to disclose. Daniel Friedman receives salary support for consulting and clinical trial related activities performed on behalf of The Epilepsy Study Consortium, a non-profit organization. Dr. Friedman receives no personal income for these activities. NYU receives a fixed amount from the Epilepsy Study Consortium towards Dr. Friedman’s salary. Within the past two years, The Epilepsy Study Consortium received payments for research services performed by Dr. Friedman from: Biogen, Cerevel, Cerebral, Crossject, Engage Pharmaceuticals, Eisai, Lundbeck, Pfizer, SK Life Science, and Xenon. He has also served as a paid consultant for Neurelis Pharmaceuticals and Receptor Life Sciences. He has received research support from Epitel. He serves on the scientific advisory board for Receptor Life Sciences. He holds equity interests in Neuroview Technology. He received royalty income from Oxford University Press. Martha Sajatovic has served as a paid consultant for Alkermes, Otsuka, Janssen, Myriad, Health Analytics, Frontline Medical Communications. She collected royalties from Springer Press, Johns Hopkins University Press, Oxford Press, UpToDate. She has received compensation for preparation of CME activities from American Physician’s Institute, MCM Education, CMEology, Potomac Center for Medical Education, Global Medical Education, Creative Educational Concepts, Psychopharmacology Institute., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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49. MINDSET: Clinic-based decision support demonstrates longitudinal efficacy for increased epilepsy self-management adherence among Spanish speaking patients.
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Shegog R, Begley C, Chong J, Sepulveda R, Addy R, Martin K, Rosales O, Halavacs N, and Labiner D
- Subjects
- Adult, Arizona, Female, Humans, Male, Middle Aged, Texas, Decision Support Systems, Clinical, Epilepsy rehabilitation, Patient Compliance, Self-Management methods
- Abstract
Background: MINDSET, a bilingual (Eng./Span.) decision support tool was found feasible for facilitating goal-based epilepsy self-management (ESM) in the clinic., Purpose: To evaluate the efficacy of MINDSET to increase ESM adherence among Hispanic patients., Methods: A RCT was conducted from August 2017 through January 2019. Spanish and English speaking Hispanic adult patients (n=94) with epilepsy in Arizona (n=53) and Texas (n=41) were randomly assigned within 6 neurology clinics to treatment (MINDSET plus Usual Care, hereafter referred to as MINDSET; n=46) and comparison (Usual Care Only; n=48) conditions. Self-reported self-management behavior (assessed through the Epilepsy Self-management scale) were categorized as adherent if performed 'usually' or 'always.' The proportion of adherence was compared between study conditions for 36 individual ESM behaviors and 5 ESM domains using Fischer's exact test., Results: The average time between visit 1 through 3 was 350+/-79 days with retention at 96.8%. Participants in the treatment condition had more college education and less unemployment. Self-management adherence improved across visits for all self-management behaviors irrespective of study condition. Compared to usual care MINDSET use led to greater ESM adherence for 86.1% behaviors (5 with statistical significance; p<0.05) and to significant improvement in the ESM domain of 'information management' (p<0.05)., Conclusions: Implementation of MINDSET within regular neurology visits may assist Hispanic adults with epilepsy to increase their adherence to ESM behaviors and maintain this adherence longitudinally. Replication with a broader demographic population of people with epilepsy is indicated., Competing Interests: Declaration of Competing Interest There is no conflict of interest associated with this research., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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50. "Bringing on the light" in a complex clinical scenario: Optical coherence tomography-guided discontinuation of antiplatelet therapy in cancer patients with coronary artery disease (PROTECT-OCT registry).
- Author
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Iliescu CA, Cilingiroglu M, Giza DE, Rosales O, Lebeau J, Guerrero-Mantilla I, Lopez-Mattei J, Song J, Silva G, Loyalka P, Paixao ARM, Yusuf SW, Perin E, Anderson VH, and Marmagkiolis K
- Subjects
- Aged, Coronary Angiography, Coronary Artery Disease complications, Coronary Artery Disease diagnosis, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Registries, Time Factors, Coronary Artery Disease therapy, Coronary Vessels diagnostic imaging, Neoplasms complications, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors therapeutic use, Tomography, Optical Coherence methods, Withholding Treatment
- Abstract
Background: Cancer patients with recently placed drug-eluting stents (DESs) often require premature dual antiplatelet therapy (DAPT) discontinuation for cancer-related procedures. Optical coherence tomography (OCT) can identify risk factors for stent thrombosis such as stent malapposition, incomplete strut coverage and in-stent restenosis and may help guide discontinuation of DAPT., Methods: We conducted a single-center prospective study in cancer patients with recently placed (1-12 months) DES who required premature DAPT discontinuation. Patients were evaluated with diagnostic coronary angiogram and OCT. Individuals with appropriate stent strut coverage, expansion, apposition, and absence of in-stent restenosis or intraluminal masses were considered low risk and transiently discontinued DAPT to allow optimal cancer therapy. Patients who did not meet all these criteria were considered high risk and underwent further endovascular treatment when appropriate and bridging with low-molecular weight heparin. The incidence of adverse cardiovascular events was assessed after the procedure and at 12 months., Results: A total of 40 patients were included. Twenty-seven patients (68%) were considered low risk by OCT criteria and DAPT was transiently discontinued. Thirteen patients (32%) were considered high risk with one or more OCT findings: uncovered stent struts (4 patients, 10%); stent underexpansion (3 patients, 8%); malapposition (8 patients, 20%); in-stent restenosis (2 patients, 5%). The high-risk patients with uncovered stent struts and malapposition underwent additional stent dilatation. There were no cardiovascular events in the low-risk group. One myocardial infarction occurred in the high-risk group. Fourteen non-cardiac deaths were registered before 12 months due to cancer progression or cancer therapy., Conclusion: OCT imaging allows identification of low-risk cancer patients with DES placed who may safely discontinue DAPT and proceed with cancer-related surgery or procedures., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
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