1. Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty.
- Author
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Shaaban, C, Rosano, Caterina, Zhu, Xiaonan, Rutherford, Bret, Witonsky, Kailyn, Rosso, Andrea, Yaffe, Kristine, and Brown, Patrick
- Subjects
Biological aging ,Executive function ,Global cognition ,Physical function ,Humans ,Female ,Aged ,Male ,Frailty ,Neuropsychological Tests ,Cognitive Dysfunction ,Cognition ,Aging - Abstract
BACKGROUND: Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA. METHODS: To make our approach clinically accessible, we created easy-to-interpret participant groups in the Health, Aging, and Body Composition Study (N = 2 458, 52% female participants, 65% White participants, age: 73.5 ± 2.8) based on medians of CA, and a previously validated BA index comprised of readily available clinical tests. Joint models estimated associations of BA-CA group with cognition (Modified Mini-Mental State Examination [3MS] and Digit Symbol Substitution Test [DSST]) and frailty over 10 years. RESULTS: The sample included the following: 32%, Young group (BA and CA
- Published
- 2023