36 results on '"Rosato, Lodovico"'
Search Results
2. Autotransplantation of the Parathyroid Glands in Thyroidectomy: The Role of Autofluorescence and Indocyanine Green
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Rosato, Lodovico, Panier Suffat, Luca, Testini, Mario, editor, and Gurrado, Angela, editor
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- 2024
- Full Text
- View/download PDF
3. Autotransplantation of the Parathyroid Glands in Thyroidectomy: The Role of Autofluorescence and Indocyanine Green
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Rosato, Lodovico, primary and Panier Suffat, Luca, additional
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- 2023
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4. Patient Information for Surgery in Primary and Secondary Hyperparathyroidism
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Nasi, Pier Giorgio, Rosato, Lodovico, Gasparri, Guido, editor, Palestini, Nicola, editor, Camandona, Michele, editor, and Corcione, Francesco
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- 2016
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5. A proposal for thyroid surgery: criteria to identify the references of endocrine surgery
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Suffat, Luca Panier, Mondini, Guido, Demaria, Federica, Perino, Paola, Bertotti, Lorenza, and Rosato, Lodovico
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- 2017
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6. Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series
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Conzo, Giovanni, Avenia, Nicola, Ansaldo, Gian Luca, Calò, Piergiorgio, De Palma, Maurizio, Dobrinja, Chiara, Docimo, Giovanni, Gambardella, Claudio, Grasso, Marica, Lombardi, Celestino Pio, Pelizzo, Maria Rosa, Pezzolla, Angela, Pezzullo, Luciano, Piccoli, Micaela, Rosato, Lodovico, Siciliano, Giuseppe, Spiezia, Stefano, Tartaglia, Ernesto, Tartaglia, Francesco, Testini, Mario, Troncone, Giancarlo, and Signoriello, Giuseppe
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- 2017
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7. Updates to improve oncological results in rectal cancer
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Luca Panier Suffat, Piva Cristina, Petrelli Lavinia, Beggaito Marco, Manuguerra Giovanna, Sculli Carla, Pileci Stefano, Lettini Ivan, La Porta Maria Rosa, and Rosato Lodovico
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Oncology ,Surgery ,General Medicine - Published
- 2023
8. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement
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Garberoglio, Roberto, Aliberti, Camillo, Appetecchia, Marialuisa, Attard, Marco, Boccuzzi, Giuseppe, Boraso, Flavio, Borretta, Giorgio, Caruso, Giuseppe, Deandrea, Maurilio, Freddi, Milena, Gallone, Gabriella, Gandini, Giovanni, Gasparri, Guido, Gazzera, Carlo, Ghigo, Ezio, Grosso, Maurizio, Limone, Paolo, Maccario, Mauro, Mansi, Luigi, Mormile, Alberto, Nasi, Pier Giorgio, Orlandi, Fabio, Pacchioni, Donatella, Pacella, Claudio Maurizio, Palestini, Nicola, Papini, Enrico, Pelizzo, Maria Rosa, Piotto, Andrea, Rago, Teresa, Riganti, Fabrizio, Rosato, Lodovico, Rossetto, Ruth, Scarmozzino, Antonio, Spiezia, Stefano, Testori, Ornella, Valcavi, Roberto, Veltri, Andrea, Vitti, Paolo, and Zingrillo, Matteo
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- 2015
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9. Post-thyroidectomy chronic asthenia: self-deception or disease?
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Rosato, Lodovico, Pacini, Furio, Panier Suffat, Luca, Mondini, Guido, Ginardi, Adriana, Maggio, Maurizio, Bosco, Maria Cristina, and Della Pepa, Carlo
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- 2015
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10. Hypocalcemia following thyroid surgery: incidence and risk factors. A longitudinal multicenter study comprising 2,631 patients
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Puzziello, Alessandro, Rosato, Lodovico, Innaro, Nadia, Orlando, Giulio, Avenia, Nicola, Perigli, Giuliani, Calò, Pietro G., and De Palma, Maurizio
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- 2014
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11. Morbidity and mortality analysis in general surgery operations. Is there any room for improvement?
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Rosato, Lodovico, primary, Lavorini, Eugenia, additional, Balzi, Daniela, additional, Mondini, Guido, additional, and Panier Suffat, Luca, additional
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- 2021
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12. Does Mediastinal Extension of the Goiter Increase Morbidity of Total Thyroidectomy? A Multicenter Study of 19,662 Patients
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Testini, Mario, Gurrado, Angela, Avenia, Nicola, Bellantone, Rocco, Biondi, Antonio, Brazzarola, Paolo, Calzolari, Filippo, Cavallaro, Giuseppe, De Toma, Giorgio, Guida, Pietro, Lissidini, Germana, Loizzi, Michele, Lombardi, Celestino Pio, Piccinni, Giuseppe, Portincasa, Piero, Rosato, Lodovico, Sartori, Nora, Zugni, Chiara, and Basile, Francesco
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- 2011
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13. Role of Growth Factors on Human Parathyroid Adenoma Cell Proliferation
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Cavallaro, Giuseppe, Cucina, Alessandra, Coluccia, Pierpaolo, Petramala, Luigi, Cotesta, Dario, Polistena, Andrea, Zinnamosca, Laura, Letizia, Claudio, Rosato, Lodovico, Cavallaro, Antonino, and De Toma, Giorgio
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- 2010
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14. Morbidity and mortality analysis in general surgery operations. Is there any room for improvement?
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ROSATO, Lodovico, LAVORINI, Eugenia, BALZI, Daniela, MONDINI, Guido, and PANIER SUFFAT, Luca
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- 2022
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15. Recurrent Laryngeal Nerve Damage and Phonetic Modifications after Total Thyroidectomy: Surgical Malpractice Only or Predictable Sequence?
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Rosato, Lodovico, Carlevato, Maria Teresa, De Toma, Giorgio, and Avenia, Nicola
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- 2005
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16. Complications of Thyroid Surgery: Analysis of a Multicentric Study on 14,934 Patients Operated on in Italy over 5 Years
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Rosato, Lodovico, Avenia, Nicola, Bernante, Paolo, De Palma, Maurizio, Gulino, Giuseppe, Nasi, Pier Giorgio, Pelizzo, Maria Rosa, and Pezzullo, Luciano
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- 2004
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17. Does the Combined Use of Magnification Loupes and Harmonic FOCUS Improve the Outcome of Thyroid Surgery?
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Suffat, Luca P, primary, Lavorini, Eugenia, additional, Mondini, Guido, additional, Lettini, Ivan, additional, Osella, Giulia, additional, and Rosato, Lodovico, additional
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- 2020
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18. Recurrent proliferating trichilemmal cyst of the scalp
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Garetto, Franca, primary, Morozzo, Giorgio, additional, Morozzo, Umberto, additional, and Rosato, Lodovico, additional
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- 2018
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19. Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series
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Conzo, Giovanni, primary, Avenia, Nicola, additional, Ansaldo, Gian Luca, additional, Calò, Piergiorgio, additional, De Palma, Maurizio, additional, Dobrinja, Chiara, additional, Docimo, Giovanni, additional, Gambardella, Claudio, additional, Grasso, Marica, additional, Lombardi, Celestino Pio, additional, Pelizzo, Maria Rosa, additional, Pezzolla, Angela, additional, Pezzullo, Luciano, additional, Piccoli, Micaela, additional, Rosato, Lodovico, additional, Siciliano, Giuseppe, additional, Spiezia, Stefano, additional, Tartaglia, Ernesto, additional, Tartaglia, Francesco, additional, Testini, Mario, additional, Troncone, Giancarlo, additional, and Signoriello, Giuseppe, additional
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- 2016
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20. Protocolli gestionali-diagnostico-terapeutico-assistenziali in chirurgica tiroidea. 2° Consensus Conference
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Agate, Laura, Ansaldo Gian Luca, Ardito, Guglielmo, Arlandini, Anselmo, Avenia, Nicola, Barbarisi, Alfonso, Bastagli, Amelia, Bellantone, Rocco, Beretta, Edoardo, Bettini, Dario, Bonfitto, Nazario, Boniardi, Marco, Botrugno, Ivan, Bronzetti, Benedetto, Calzolari, Filippo, Campana Francesco Paolo, Cannizzaro Matteo Angelo, Caruso, Giuseppe, Cavallaro, Giuseppe, Cesari, Marco, Chiofalo Maria Grazia, Cofini, Guido, Costanzo, Mario, D’Ajello, Michele, Dal Dosso Ivano, De Martino Daniele, De Nobili Umberto, De Palma Maurizio, De Santis Luigi, De Toma Giorgio, Deandrea, Marisa, Dobrinja, Chiara, Docimo, Giovanni, Donatini, Gianluca, Elisei, Rossella, Falvo, Laura, Faragona, Sandro, Faverio, Francesco, Fonsi Giovanni Battista, Gasparri, Guido, Ginardi, Adriana, Graceffa, Giuseppina, Gurrado, Angela, Hadjiamiri, Hossein, Innaro, Nadia, La Motta Benedetto, Lampugnani, Rinaldo, Lardo, Domenica, Latteri, Adelfio, Leopaldi, Ennio, Lissidini, Germana, Lombardi Celestino Pio, Lombardi, Gaetano, Lupone, Gennaro, Marini Pier Luigi, Marzano Luigi Antonio, Marzano, Tommaso, Masi, Giulia, Miccoli, Paolo, Mobiglia, Alberto, Molinaro, Eleonora, Molinaro, Giulia, Monacelli, Massimo, Mondini, Guido, Montecamozzo, Giulio, Mullineris, Barbara, Nasi Pier Giorgio, Nicolosi, Angelo, Ortensi, Andrea, Palestini, Nicola, Palladino, Simona, Panconesi, Roberto, Pelizzo Maria Rosa, Perigli, Giuliano, Pezzullo, Luciano, Piccoli, Micaela, Pinchera, Aldo, Presenti, Luigi, Pugliese, Raffaele, Residori, Cecilia, Romano, Maurizio, Rosato, Lodovico, Sandonà, Francesco, Sandrini, Alessandro, Spiezia, Stefano, Taffurelli, Mario, Tartaglia, Francesco, Testini, Mario, Viola, David, Zaccaroni, Alberto, and Zarrilli, Lucio
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- 2009
21. Post-thyroidectomy chronic asthenia: self-deception or disease?
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Rosato, Lodovico, primary, Pacini, Furio, additional, Panier Suffat, Luca, additional, Mondini, Guido, additional, Ginardi, Adriana, additional, Maggio, Maurizio, additional, Bosco, Maria Cristina, additional, and Della Pepa, Carlo, additional
- Published
- 2014
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22. Role of Growth Factors on Human Parathyroid Adenoma Cell Proliferation
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Cavallaro, Giuseppe, primary, Cucina, Alessandra, additional, Coluccia, Pierpaolo, additional, Petramala, Luigi, additional, Cotesta, Dario, additional, Polistena, Andrea, additional, Zinnamosca, Laura, additional, Letizia, Claudio, additional, Rosato, Lodovico, additional, Cavallaro, Antonino, additional, and De Toma, Giorgio, additional
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- 2009
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23. Antibiotic prophylaxis in thyroid surgery: a preliminary multicentric italian experience
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Avenia, Nicola, primary, Sanguinetti, Alessandro, additional, Cirocchi, Roberto, additional, Docimo, Giovanni, additional, Ragusa, Mark, additional, Ruggiero, Roberto, additional, Procaccini, Eugenio, additional, Boselli, Carlo, additional, D'Ajello, Fabio, additional, Barberini, Francesco, additional, Parmeggiani, Domenico, additional, Rosato, Lodovico, additional, Sciannameo, Francesco, additional, De Toma, Giorgio, additional, and Noya, Giuseppe, additional
- Published
- 2009
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24. Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series
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Maria Rosa Pelizzo, Piergiorgio Calò, Giancarlo Troncone, Maurizio De Palma, Angela Pezzolla, Giovanni Conzo, Chiara Dobrinja, Giuseppe Signoriello, Marica Grasso, Giuseppe Siciliano, Gian Luca Ansaldo, Lodovico Rosato, Claudio Gambardella, Luciano Pezzullo, Mario Testini, Micaela Piccoli, Nicola Avenia, Celestino Pio Lombardi, Stefano Spiezia, Ernesto Tartaglia, Francesco Tartaglia, Giovanni Docimo, Conzo, Giovanni, Avenia, Nicola, Ansaldo, Gian Luca, Calò, Piergiorgio, De Palma, Maurizio, Dobrinja, Chiara, Docimo, Giovanni, Gambardella, Claudio, Grasso, Marica, Lombardi, Celestino Pio, Pelizzo, Maria Rosa, Pezzolla, Angela, Pezzullo, Luciano, Piccoli, Micaela, Rosato, Lodovico, Siciliano, Giuseppe, Spiezia, Stefano, Tartaglia, Ernesto, Tartaglia, Francesco, Testini, Mario, Troncone, Giancarlo, Signoriello, Giuseppe, Conzo, G., Avenia, N., Ansaldo, G. L., Calo, P., De Palma, M., Dobrinja, C., Docimo, G., Gambardella, C., Grasso, M., Lombardi, C. P., Pelizzo, M. R., Pezzolla, A., Pezzullo, L., Piccoli, M., Rosato, L., Siciliano, G., Spiezia, S., Tartaglia, E., Tartaglia, F., Testini, M., Troncone, G., Signoriello, G., and de Palma, Maurizio
- Subjects
Male ,Fine needle cytology ,Follicular neoplasm ,Hemithyroidectomy ,Thyroid cancer ,Total thyroidectomy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Thyroid Gland ,Thyroiditis ,Postoperative Complications ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Retrospective Studie ,Adenocarcinoma, Follicular ,Thyroid Neoplasm ,Adult ,Aged ,Female ,Humans ,Hypoparathyroidism ,Middle Aged ,Retrospective Studies ,Thyroid Neoplasms ,Thyroidectomy ,Treatment Outcome ,Thyroid ,Diabetes and Metabolism ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Human ,Thyroid nodules ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Adenocarcinoma ,Malignancy ,03 medical and health sciences ,medicine ,business.industry ,Risk Factor ,Follicular ,medicine.disease ,Surgery ,Endocrine surgery ,Postoperative Complication ,business - Abstract
The most appropriate surgical management of "follicular neoplasm/suspicious for follicular neoplasm" lesions (FN), considering their low definitive malignancy rate and the limited predictive power of preoperative clinic-diagnostic factors, is still controversial. On behalf of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB), we collected and analyzed the experience of 26 endocrine centers by computerized questionnaire. 1379 patients, surgically treated after a FN diagnosis from January 2012 and December 2103, were evaluated. Histological features, surgical complications, and medium-term outcomes were reported. Total thyroidectomy (TT) was performed in 1055/1379 patients (76.5 %), while hemithyroidectomy (HT) was carried out in 324/1379 cases (23.5 %). Malignancy rate was higher in TT than in HT groups (36.4 vs. 26.2 %), whereas the rates of transient and definitive hypoparathyroidism following TT were higher than after HT. Consensual thyroiditis (16.8 vs. 9.9 %) and patient age (50.9 vs. 47.9 %) also differed between groups. A cytological FN diagnosis was associated to a not negligible malignancy rate (469/1379 patients; 34 %), that was higher in TT than in HT groups. However, a lower morbidity rate was observed in HT, which should be considered the standard of care in solitary lesions in absence of specific risk factors. Malignancy could not be preoperatively assessed and clinical decision-making is still controversial. Further efforts should be spent to more accurately preoperatively classify FN thyroid nodules. The most appropriate surgical management of “follicular neoplasm/suspicious for follicular neoplasm” lesions (FN), considering their low definitive malignancy rate and the limited predictive power of preoperative clinic-diagnostic factors, is still controversial. On behalf of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB), we collected and analyzed the experience of 26 endocrine centers by computerized questionnaire. 1379 patients, surgically treated after a FN diagnosis from January 2012 and December 2103, were evaluated. Histological features, surgical complications, and medium-term outcomes were reported. Total thyroidectomy (TT) was performed in 1055/1379 patients (76.5 %), while hemithyroidectomy (HT) was carried out in 324/1379 cases (23.5 %). Malignancy rate was higher in TT than in HT groups (36.4 vs. 26.2 %), whereas the rates of transient and definitive hypoparathyroidism following TT were higher than after HT. Consensual thyroiditis (16.8 vs. 9.9 %) and patient age (50.9 vs. 47.9 %) also differed between groups. A cytological FN diagnosis was associated to a not negligible malignancy rate (469/1379 patients; 34 %), that was higher in TT than in HT groups. However, a lower morbidity rate was observed in HT, which should be considered the standard of care in solitary lesions in absence of specific risk factors. Malignancy could not be preoperatively assessed and clinical decision-making is still controversial. Further efforts should be spent to more accurately preoperatively classify FN thyroid nodules.
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- 2017
25. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement
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Roberto Valcavi, Guido Gasparri, Giuseppe Caruso, Alberto Mormile, Giovanni Gandini, Teresa Rago, Carlo Gazzera, Roberto Garberoglio, Matteo Zingrillo, Marco Attard, Giuseppe Boccuzzi, Marialuisa Appetecchia, Maria Rosa Pelizzo, Stefano Spiezia, Antonio Scarmozzino, Giorgio Borretta, Maurilio Deandrea, Andrea Veltri, Paolo Piero Limone, Luigi Mansi, Camillo Aliberti, Andrea Piotto, Donatella Pacchioni, Flavio Boraso, Gabriella Gallone, Milena Freddi, Nicola Palestini, Lodovico Rosato, Paolo Vitti, Maurizio Grosso, Mauro Maccario, Fabrizio Riganti, P. G. Nasi, Enrico Papini, Fabio Orlandi, R. Rossetto, Ornella Testori, Claudio Maurizio Pacella, Ezio Ghigo, Garberoglio, Roberto, Aliberti, Camillo, Appetecchia, Marialuisa, Attard, Marco, Boccuzzi, Giuseppe, Boraso, Flavio, Borretta, Giorgio, Caruso, Giuseppe, Deandrea, Maurilio, Freddi, Milena, Gallone, Gabriella, Gandini, Giovanni, Gasparri, Guido, Gazzera, Carlo, Ghigo, Ezio, Grosso, Maurizio, Limone, Paolo, Maccario, Mauro, Mansi, Luigi, Mormile, Alberto, Nasi, Pier Giorgio, Orlandi, Fabio, Pacchioni, Donatella, Pacella, Claudio Maurizio, Palestini, Nicola, Papini, Enrico, Pelizzo, Maria Rosa, Piotto, Andrea, Rago, Teresa, Riganti, Fabrizio, Rosato, Lodovico, Rossetto, Ruth, Scarmozzino, Antonio, Spiezia, Stefano, Testori, Ornella, Valcavi, Roberto, Veltri, Andrea, Vitti, Paolo, and Zingrillo, Matteo
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Thyroid nodules ,endocrine system ,medicine.medical_specialty ,Goiter ,endocrine system diseases ,medicine.medical_treatment ,Population ,Cryotherapy ,Nodular thyroid disease ,Nuclear Medicine and Imaging ,medicine ,Internal Medicine ,Radiology, Nuclear Medicine and imaging ,education ,Letter to the Editor ,education.field_of_study ,business.industry ,Thyroid ,Radiofrequency ablation ,Nodule (medicine) ,General Medicine ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Radiology, Nuclear Medicine and Imaging ,Thyroid function ,medicine.symptom ,Percutaneous ethanol injection ,Settore MED/36 - Diagnostica Per Immagini E Radioterapia ,business ,Radiology - Abstract
Nodular thyroid disease is a very common finding in clinical practice, discovered by ultrasound (US) in about 50 % of the general population, with higher prevalence in women and in the elderly [1–4]. Whereas therapeutic flowchart is quite established and shared for malignant lesions, multiple options are now available for patients presenting with benign thyroid nodules, ranging from simple clinical and US follow-up to thyroid surgery. The majority of thyroid nodules, benign by fine-needle aspiration, are asymptomatic, stable, or slow-growing over time and require no treatment. Nevertheless, large thyroid nodules may become responsible for pressure symptoms, resulting in neck discomfort, cosmetic complaints, and decreased quality of life. Partial/total thyroid surgery has so far constituted the only therapeutic approach for these. Although surgery is widely available, highly effective, and safe in skilled centers, complications (both temporary and permanent) still occur in 2–10 % of cases [5, 6]. Hypothyroidism is an unavoidable effect after total thyroidectomy, requiring lifelong l-thyroxine replacement therapy. Besides, surgery is expensive and may be not recommended for high-risk patients or refused by others. Radioiodine (131I) therapy has been proven to be effective to treat toxic multinodular goiters and autonomously functioning thyroid nodules (AFTN) [7], although they are usually more radioresistant than toxic diffuse goiters [8]. Radioiodine therapy normalizes thyroid function and significantly reduces thyroid volume. However, hypothyroidism often occurs, in up to 60 % of patients, several years after treatment [9]. Otherwise, radioiodine therapy shows only incomplete, weak effects in nonfunctioning cold thyroid nodules. Pretreatment with recombinant human TSH may improve goiter volume reduction by causing a more homogeneous distribution of radioiodine within the gland, especially increasing the uptake of 131I in scintigraphically relatively cold areas [10]. TSH-suppression therapy withl-thyroxine was widely used to achieve nodule shrinkage and to prevent nodule growth and formation, producing, however, controversial results and exposing patients to heart and bone side effects. Therefore, current guidelines do not recommend its routine use in clinical practice, suggesting its usefulness in some cases only [3, 4]. Over the last two decades, nonsurgical, minimally invasive, US-guided techniques have been proposed for the treatment of thyroid nodules [11–16]. Percutaneous ethanol injection (PEI) is recommended for the treatment of relapsing cysts and dominantly cystic thyroid nodules [17]. Because of the limitations of PEI in the management of solid thyroid nodules, hyperthermic methods (laser ablation and radiofrequency ablation) have been introduced afterward for the treatment of solid, benign thyroid lesions [18], achieving marked nodule size reduction and clinical improvement in nodule-related symptoms, in several series from skilled centers, especially in Korea and Italy. Other nonsurgical therapies, such as high-intensity focused-ultrasound (HIFU), microwaves, cryotherapy, and electroporation, are presently under investigation.
- Published
- 2015
26. Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour.
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Gurrado A, Pasculli A, Avenia N, Bellantone R, Boniardi M, Merante Boschin I, Calò PG, Camandona M, Cavallaro G, Cianchi F, Conzo G, D'Andrea V, De Crea C, De Pasquale L, Del Rio P, Di Meo G, Dionigi G, Dobrinja C, Docimo G, Famà F, Galimberti A, Giacomelli L, Graceffa G, Iacobone M, Innaro N, Lombardi CP, Materazzi G, Medas F, Mullineris B, Oragano L, Palestini N, Perigli G, Pezzolla A, Prete FP, Raffaelli M, Renzulli G, Rosato L, Scerrino G, Sgaramella LI, Sorrenti S, Testini C, Veroux M, Gasparri G, and Testini M
- Abstract
Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT)., Methods: All relevant information was collected about PC and APT patients treated between 2009 and 2021., Results: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates ( p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%., Conclusions: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.
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- 2023
- Full Text
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27. Percutaneous cholecystostomy and acute cholecystitis: how, when and why.
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Suffat LP, Petrelli LC, Mondini G, Beggiato M, Lettini I, Bono L, and Rosato L
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- Cholecystectomy adverse effects, Humans, Retrospective Studies, Treatment Outcome, Cholecystitis, Acute surgery, Cholecystostomy adverse effects
- Abstract
Aim: Acute cholecystitis (AC) is one of the most frequent pathologies treated in urgency. An immediate surgical intervention for frail patients who are ineligible for surgery as a result of severe co-morbidities is questionable. The aim of this study is to investigate the safety and the management of percutaneous cholecistostomy (PC) in high-risk surgical patients., Materials and Methods: In the period of time January 2015 - May 2021 we observed 1105 patients admitted with acute cholecystitis in our Department. In the group with severe cholecystitis (160 patients, 14.48%), 137 (12.39%) were submitted to immediate surgery, and 23 (4.8%) were treated with PC. All these patients were non-responding to conservative management. Initially, we used PC as a definitive treatment; from the second half of 2018 PC was implemented as a bridge to surgery., Results: Clinically, symptoms resolved in all the 23 patients. Mortality was nihil and no complication was recorded. PC was used as definitive treatment in 14 cases, wheres in 9 patients PC was intended as a-bridge-to-surgery treatment, and was followed by cholecystectomy., Discussion: 2017 guidelines, of World Society of Emergency Surgery recommended PC as a safe and effective management of AC in patients with multiple comorbidities. In this group of patients PC achieves a prompt resolution of clinical symptoms and is superior to conservative management. There are no absolute contraindications to PC., Conclusions: PC is a safe and less invasive treatment of AC for patients with prohibitive surgical risk. It may be used as bridge to surgery to switch high-risk for moderate-risk patients, more suitable for a safe and definitive surgical treatment., Key Words: Acute cholecystitis, High-risk surgical patients, Percutaneous cholecystostomy.
- Published
- 2022
28. Ideal level of ligation of the inferior mesenteric artery. An old debate for a current surgical approach.
- Author
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Suffat LP, Petrelli LC, Mondini G, Lettini I, Bono L, Marsengo R, Bergantino A, and Rosato L
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- Humans, Ligation, Lymph Node Excision, Lymph Nodes, Mesenteric Artery, Inferior surgery, Retrospective Studies, Laparoscopy, Rectal Neoplasms surgery
- Abstract
Aim: The ideal level of ligation of the inferior mesenteric artery (IMA) during resection for colorectal cancer is still controversial. The aim of this study was to demonstrate the real advantages and, above all, the adequacy of oncological staging after a low ligation of the IMA with additional LN retrieval in patients undergoing surgery for colorectal cancer., Materials and Methods: Between January 2013 and December 2020, 157 patients who underwent curative resection of a primary colorectal tumor were retrospectively included: 64 patients underwent high ligation of the IMA and 93 patients underwent low ligation of the IMA with additional LN retrieval. Results - Mean number of lymphnodes harvested (the median number of harvested nodes was 16.2 in "high ligation" group vs 15.4 in "low ligation" group), operation time (272 minutes vs 293 minutes), intraoperative blood loss (40 cc vs 53 cc) and recovery time (median postoperative hospitalization was 6.4 days in both groups) were not significantly different between the groups., Discussion: High ligation of the IMA preserves an adequate length of the colon to perform a successful anastomosis and facilitates apical LN dissection. However, it may be associated with an increased risk of anastomotic leakage. Low ligation of the IMA is less invasive and it is associated with a better preservation of genitourinary function and, futhermore, with an accurate oncological clearance., Conclusion: Low ligation of the IMA with additional LN retrieval might be an oncologically safe and less invasive procedure in the surgical management of patients with colorectal cancer., Key Words: Colorectal cancer, Inferior mesenteric artery, Ligation.
- Published
- 2021
29. Blunt splenic trauma 2.0. State of the art.
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Lavorini E, Bono L, Osella G, Rosato L, Mondini G, and Suffat LP
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- Humans, Injury Severity Score, Retrospective Studies, Splenectomy, Trauma Centers, Treatment Outcome, Abdominal Injuries surgery, Abdominal Injuries therapy, Spleen injuries, Spleen surgery, Wounds, Nonpenetrating surgery, Wounds, Nonpenetrating therapy
- Abstract
Aim: To evaluate the advantages and potential risks of "Non Operative Management" (NOM) in order to redifine the technique into the true gold standard and to extend its application to the emergency care of blunt splenic trauma., Materials and Methods: Blunt trauma cases treated between 2004 and 2019 have been retrospectively evaluated. Every patient has been distributed at the hospital admission in 3 different groups: stable, unstable and transient responder according to ATLS. NOM exclusion criteria were only introduced in 2013: we therefore assessed datas before and after this year., Results: Over a period of 15 years, approximately 6 patients per year were admitted to our hospital with a spleen injury. After the introduction of the NOM protocol in 2013, the proportion of splenectomies progressively decreased. This rate also increased for higher injury grades. The overall number of patients who underwent NOM was 40 (43%), but while between 2004 and 2012 only 25% of patients were managed with NOM, between 2013 and 2019 70.3% of patients were treated with NOM., Conclusions: Nowadays any blunt splenic trauma could, theoretically, undergo NOM, regardless of the grade of the injury; the only strict criteria for OM should be haemodynamic instability; this assumption depends, of course, on hospital's human and technological resources., Key Words: Non operative management, Splenic trauma, Splenectomy.
- Published
- 2021
30. Recurrent proliferating trichilemmal cyst of the scalp.
- Author
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Garetto F, Morozzo G, Morozzo U, and Rosato L
- Subjects
- Biopsy, Epidermal Cyst pathology, Epidermal Cyst surgery, Female, Humans, Middle Aged, Recurrence, Scalp Dermatoses pathology, Scalp Dermatoses surgery, Skin Transplantation methods, Tomography, X-Ray Computed, Epidermal Cyst diagnosis, Scalp pathology, Scalp Dermatoses diagnosis
- Abstract
Pilar tumors, commonly called trichilemmal cysts, are usually benign in nature, malignant transformation (so called proliferating pilar tumors or proliferating trichilemmal cysts [PTCs]) with high recurrence rates, local invasion and metastases have been described. A 64-year-old women presented to our hospital with a recurrent ulcerated mass lesion of the scalp. Non-contrast-enhanced computed tomography scan of the head was performed. The mass was managed by complete excisional biopsy and the defect closure was achieved by using a full-thickness skin graft. Histopathological analysis revealed the characteristic structures of PTC; in addition foci of squamous pearls, squamous cells with pleomorphic nuclei suggestive of cellular atypia and increased typical mitotic activity were also noticed. PTCs are related to high recurrency rates, local invasion and possible metastases. Radical surgical treatment and precise histological analysis are essential in order to achieve a fast and complete healing. Cooperation of the clinician and the pathologist is essential for accurate diagnosis, treatment and follow-up planning.
- Published
- 2018
- Full Text
- View/download PDF
31. Do Italian surgeons use antibiotic prophylaxis in thyroid surgery? Results from a national study (UEC--Italian Endocrine Surgery Units Association).
- Author
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Gentile I, Rosato L, Avenia N, Testini M, D'Ajello M, Antonino A, and De Palma M
- Subjects
- Female, Humans, Italy, Male, Middle Aged, Parathyroid Glands, Surgeons, Thyroid Gland, Antibiotic Prophylaxis statistics & numerical data, Practice Patterns, Physicians', Thyroidectomy
- Abstract
Thyroid surgery is a clean procedure and therefore antibiotic prophylaxis is not routinely recommended by most international guidelines. However, antibiotics are often used in clinical practice. We enrolled 2926 patients who performed a thyroid surgical operation between the years 2009 and 2011 in the 38 centers of endocrine surgery that joined the UEC--Italian Endocrine Surgery Units Association. Antibiotic prophylaxis was used in 1132 interventions (38.7%). In case of antibiotic prophylaxis, cephalosporins or aminopenicillins ± beta lactamase inhibitors were employed. At logistic regression analysis the use of drainage or device and the presence of malignancy were independent predictors of antibiotic prophylaxis employment. In conclusion our study shows that antibiotic prophylaxis was not rarely used in clinical practice in the setting of thyroid surgery. Drainage apposition, use of device, and malignant disease were independent predictors for antibiotic prophylaxis employment. More data on everyday practice and infection rate in well-designed studies are warranted to provide definitive recommendations on the utility of antibiotic prophylaxis in this setting. According to our experience, we don't consider to be strictly necessary the antibiotic prophylaxis employment in order to reduce infection rate in thyroid surgery.
- Published
- 2014
32. [Antibiotic prophylaxis in breast surgery. Preliminary resuls of a multicenter randomized study on 1400 cases].
- Author
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Sanguinetti A, Rosato L, Cirocchi R, Barberini F, Pezzolla A, Cavallaro G, Parmeggiani D, Ruggiero R, Docimo G, Procaccini E, Santoriello A, Rulli A, Gubitosi A, Canonico S, Taffurelli M, Sciannameo F, Barbarisi A, Docimo L, Agresti M, De Toma G, Noya G, Parmeggiani U, and Avenia N
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Amoxicillin administration & dosage, Amoxicillin therapeutic use, Anti-Bacterial Agents administration & dosage, Cefazolin administration & dosage, Clavulanic Acid administration & dosage, Clavulanic Acid therapeutic use, Data Interpretation, Statistical, Female, Humans, Middle Aged, Odds Ratio, Patient Selection, Surgical Wound Infection drug therapy, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis, Breast Diseases surgery, Breast Neoplasms surgery, Cefazolin therapeutic use, Mastectomy, Radical, Mastectomy, Segmental, Surgical Wound Infection prevention & control
- Abstract
Unlabelled: Breast surgery is classified among the procedures performed in clean surgery and is associated with a low incidence of wound infection (3-15%). The objective of this study was to evaluate the advantages antibiotic prophylaxis in patients undergoing breast surgery. A multicenter randomized controlled study was performed between January 2008 and November 2008. One thousand four hundred patients were enrolled in prospective randomized study; surgical wound infection was found in 41 patients (2.93%). In our RCT we have shown that in breast surgery antibiotic prophylaxis does not present significant advantages in patients with potential risk of infection (17 patients, 2.42%, subjected to antibiotic prophylaxis vs 24 patients, 3.43%, without antibiotic prophylaxis) (P = 0.27). In patients with drainage there is a significant minor incidence of wound infections in patients receiving antibiotic prophylaxis (5 patients, 0.92%, subjected to antibiotic prophylaxis vs 14 patients, 3.09%, without antibiotic prophylaxis) (P = 0.02)., Conclusion: This study is only a preliminary RCT to be followed by a study which should be enrolled more patients in order to get the results as statistically significant.
- Published
- 2009
33. Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study.
- Author
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Calzolari F, Sartori PV, Talarico C, Parmeggiani D, Beretta E, Pezzullo L, Bovo G, Sperlongano P, Monacelli M, Lucchini R, Misso C, Gurrado A, D'Ajello M, Uggeri F, Puxeddu E, Nasi P, Testini M, Rosato L, Barbarisio A, and Avenia N
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma secondary, Adenocarcinoma surgery, Adult, Aged, Biopsy, Fine-Needle, Breast Neoplasms pathology, Carcinoma, Renal Cell pathology, Carcinoma, Renal Cell secondary, Carcinoma, Renal Cell surgery, Colonic Neoplasms pathology, Female, Follow-Up Studies, Humans, Kidney Neoplasms pathology, Lung Neoplasms pathology, Male, Middle Aged, Retrospective Studies, Thyroid Neoplasms pathology, Thyroid Neoplasms secondary, Thyroid Neoplasms surgery
- Abstract
Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options., Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM., Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40%) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months., Conclusion: ITM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland.
- Published
- 2008
34. [Neurendocrine tumours of the appendix, colon and rectum: current surgical aspects].
- Author
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Rosato L, De Tomaa G, Mondini G, Bertone P, Fornari F, and Orlassino R
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Appendiceal Neoplasms diagnosis, Appendiceal Neoplasms drug therapy, Colorectal Neoplasms diagnosis, Colorectal Neoplasms drug therapy, Female, Follow-Up Studies, Hormones therapeutic use, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Minimally Invasive Surgical Procedures, Neuroendocrine Tumors diagnosis, Neuroendocrine Tumors drug therapy, Retrospective Studies, Somatostatin analogs & derivatives, Somatostatin therapeutic use, Treatment Outcome, Appendectomy methods, Appendiceal Neoplasms surgery, Colectomy methods, Colorectal Neoplasms surgery, Neuroendocrine Tumors surgery
- Abstract
Neuroendocrine tumours (NET) are a heterogeneous group of neoplasms deriving from a system of diffuse neuroendocrine cells in organs and tissues, defined as the "diffuse neuroendocrine system". Over the period from 1996 to 2005 42 patients with gastroenteropancreatic (GEP) NET were observed (M.F ratio: 1.5:1; mean age 58 years; > 60 years for all localisations except the appendix [< 39 years]). Twenty-three were tumours of the appendix, colon and rectum, corresponding to 55% of all those affecting the digestive tract: 8 appendix (35%), 6 right colon (26%), 4 left colon (17%) and 5 rectum (22%). The NET diagnosis was formulated in all cases on the basis of histological and immunohistochemical examinations. The mean follow-up period was 5 years (range: 1-10). In the RO-RI cases no relapses occurred and those who were not disease-free were treated with somatostatin analogues and/or chemotherapy. NET of the appendix, colon and rectum are rare, despite being the most frequent among the GEP tumours, and are difficult to diagnose, and therefore sometimes pose problems of surgical therapy, which, when performed in time, may be curative. NET of the appendix measuring <2 cm, localised in the distal part without local infiltration, can be treated by simple appendicectomy and removal of the mesenteriole; otherwise, right hemicolectomy is indicated. The surgical treatment of tumours of the colon, except for well differentiated cases measuring <2 cm with a pedunculate structure such as to allow safe endoscopic removal, consists in radical hemicolectomy with lymphadenectomy. Carcinoids of the rectum measuring <1 cm and 1 cm to 2 cm, in the absence of other negative prognostic factors, can be treated locally by transanal endoscopic microsurgery (TEM) or minimally invasive transanal surgery (MITAS). Tumours measuring >2 cm or presenting muscular invasion and/or lymph-node metastases (malignant carcinoids), regardless of tumour diameter, are submitted to radical operations, as in the case of carcinoma of the rectum. Extensive disease which is no longer curable with surgery alone is treated with chemotherapy and bio-chemotherapy, but it is above all treatment with somatostatin analogues that plays a major role in symptom control.
- Published
- 2007
35. [Diagnostic, therapeutic and healtcare management protocols in thyroid surgery. I consensus conference (UEC club)].
- Author
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Rosato L, Pinchera A, Bellastella A, De Antoni E, Martino E, Miccoli P, Pontecorvi A, Torre G, Vitti P, Pelizzo MR, Avenia N, Nasi PG, Bellantone R, Lampugnani R, De Palma M, Pezzullo L, Ardito G, and De Toma G
- Subjects
- Clinical Protocols, Humans, Thyroid Diseases diagnosis, Thyroid Diseases surgery, Thyroidectomy
- Abstract
The aim of the study was to draw up a management protocol in thyroid surgery promoted by the Italian Association of Endocrine Surgery Units (Club delle UEC), shared by the experts and applied by the operators in the sector. The management protocols already presented in February 2002 and drawn up by the first Author of the present publication on the occasion of the current review were examined by the I Consensus Conference called on the topic by the Italian Endocrine Surgery Units. The conference comprised two distinct sessions, the first on 18 June 2005 within the framework of the 4th National Congress of the Club delle UEC in Naples, and the second on 17 September 2005 within the framework of the 8th Multidisciplinary Scanno Prize Meeting. A selected board of endocrinologists and endocrine surgeons, chaired by Aldo Pinchera and comprising the first nine Authors of this paper, examined the individual chapters in close collaboration with the other Authors, comparing their findings with the opinions of the experts cited in the text and submitting the consensus text for the approval of all those present. The diagnostic, therapeutic and healtcare management protocols in thyroid surgery approved by the I Consensus Conference are officially those proposed by the Italian Association of Endocrine Surgery Units (Club delle UEC) and are subject to review by October 1, 2007.
- Published
- 2006
36. [Complications of total thyroidectomy: incidence, prevention and treatment].
- Author
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Rosato L, Avenia N, De Palma M, Gulino G, Nasi PG, and Pezzullo L
- Subjects
- Analysis of Variance, Female, Humans, Hypocalcemia etiology, Hypocalcemia therapy, Hypoparathyroidism etiology, Hypoparathyroidism therapy, Incidence, Male, Middle Aged, Monitoring, Intraoperative, Odds Ratio, Recurrent Laryngeal Nerve Injuries, Retrospective Studies, Risk Factors, Thyroidectomy methods, Postoperative Complications epidemiology, Postoperative Complications prevention & control, Postoperative Complications therapy, Thyroidectomy adverse effects
- Abstract
The range of indications for total thyroidectomy in the treatment of thyroid disease is steadily increasing, but any attempt to assess its real efficacy necessarily calls for a knowledge of the incidence of complications, amongst other things in order to provide the patient with complete information regarding the operation before obtaining his or her consent. Retrospective and observational analysis of 14,934 thyroidectomies performed in 42 Endocrine Surgery Units in Italy has made it possible to compare total thyroidectomy (TT) versus subtotal thyroidectomy with a bilateral remnant (ST-BR), subtotal thyroidectomy with a unilateral remnant (ST-UR) and total lobectomy-isthmectomy (TLI). The correlation between the number of total thyroidectomies and each of the other surgical procedures and the number of complications occurring with each of them was also assessed in order to quantify the effective risk of complications by determining the Odds Ratios on the basis of univariate analysis of the variables considered. The cases reviewed consisted of 9,599 TT (64%), 3,130 TLI (21%), 1,448 ST-UR (22%) and 757 ST-BR (5%); 13,023 (87%) cases were suffering from benign disease and 1,911 (13%) from malignancies. Recurrent laryngeal nerve injuries were present in 4.3% of the TT cases with 2.4% transient and 1.3% definitive (as against 3% in ST-BR and 2% in ST-UR with 1.4% and 1.1% transient, and 1% and 0.6% definitive, respectively; and 1.4% transient and 0.6% definitive in TLI). Hypocalcaemia after TT was transient in 14% and definitive in 2.2% (as against transient rates of 5% in ST-BR and ST-UR and 0.4 in TLI; and definitive hypocalcaemia in 0.6%, 0.8% and 0.07%, respectively). Haemorrhage occurred in 1.6% of TT cases (as against 2.1%, 0.5% and 0.4% in ST-BR, ST-UR and TLI, respectively). The Odds Ratios showed that TT presented a 16% higher complication rate than ST-UR which was assigned a value of 1, a 3% higher rate than ST-BR and a 5% lower rate than TLI. This greater incidence of complications with TT is attributable mainly to the greater incidence of transient hypoglycaemia and to a lesser extent to the slightly higher incidence of definitive hypoglycaemia, whereas the incidences of recurrent laryngeal nerve injuries were very similar in TT and ST-BR. Haemorrhagic complications were more frequent in ST-BR than in TT. Bearing in mind that TT is the absolute indication in the more demanding thyroid diseases (tumours, retrosternal goitre, Basedow's disease, recurrences) and in view of its fairly low complication rate, we believe that TT is a safe, reliable procedure, provided it is performed in a technically scrupulous manner. ST-BR is a technique which should be abandoned owing to the fact that its complication rate is comparable to that of TT and to the recurrences it may give rise to. ST-UR may be indicated if the surgeon is not sure of safeguarding the anatomical integrity of the recurrent nerve on one side.
- Published
- 2002
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