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159 results on '"Rosato, Valerio"'

1. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author

Aghemo, Alessio, Baiguera, Chiara, Battezzati, Pier Maria, Battistella, Sara, Bavetta, Maria Grazia, Bertoni, Costanza, Boni, Carolina, Brambilla, Paola, Bray, Antonella, Briano, Federica, Carmenini, Enrico, Castelli, Francesco, Cavalletto, Luisa, Cerini, Federica, Chidichimo, Luciana, Colella, Elisa, Cologni, Giuliana, Como, Silvia, Corsini, Romina, Costa, Chiara, Cotugno, Rosa, Cretella, Silvia, De Angelis, Fernando, De Leo, Pasqualina, Perri, Giovanni Di, Falbo, Elisabetta, Ferrigno, Luigina, Fornasiere, Ezio, Francisci, Daniela, Gatti, Pietro, Lampertico, Pietro, Lenci, Ilaria, Licata, Anna, Maida, Ivana, Marzano, Alfredo, Mastroianni, Antonio, Mazzaro, Cesare, Monti, Monica, Nardone, Gerardo, Nicolini, Laura Ambra, Passigato, Nicola, Pasticci, Maria Bruna, Pierotti, Piera, Pinchera, Biagio, Pollicino, Teresa, Porcu, Carmen, Quartini, Giulia, Rancatore, Gabriele, Romeo, Mario, Rumi, Maria Grazia, Saracino, Annalisa, Schioppa, Ornella, Serio, Ilaria, Soffredini, Roberta, Tata, Xhimi, Tizzani, Marco, Tonnini, Matteo, Torti, Carlo, Valenti, Daniela, Zaltron, Serena, Zoncada, Alessia, Kondili, Loreta A., Brancaccio, Giuseppina, Tosti, Maria Elena, Coco, Barbara, Quaranta, Maria Giovanna, Messina, Vincenzo, Ciancio, Alessia, Morisco, Filomena, Cossiga, Valentina, Claar, Ernesto, Rosato, Valerio, Ciarallo, Marianna, Cacciola, Irene, Ponziani, Francesca Romana, Cerrito, Lucia, Coppola, Roberta, Longobardi, Francesco, Biliotti, Elisa, Rianda, Alessia, Barbaro, Francesco, Coppola, Nicola, Stanzione, Maria, Barchiesi, Francesco, Fagiuoli, Stefano, Viganò, Mauro, Massari, Marco, Russo, Francesco Paolo, Ferrarese, Alberto, Laccabue, Diletta, Di Marco, Vito, Blanc, Pierluigi, Marrone, Aldo, Morsica, Giulia, Federico, Alessandro, Ieluzzi, Donatella, Rocco, Alba, Foschi, Francesco Giuseppe, Soria, Alessandro, Chessa, Luchino, Milella, Michele, Rosselli Del Turco, Elena, Madonia, Salvatore, Chemello, Liliana, Gentile, Ivan, Toniutto, Pierluigi, Bassetti, Matteo, Surace, Lorenzo, Baiocchi, Leonardo, Pellicelli, Adriano, De Santis, Adriano, Puoti, Massimo, Degasperi, Elisabetta, Niro, Grazia Anna, Zignego, Anna Linda, Craxi, Antonio, Raimondo, Giovanni, Santantonio, Teresa Antonia, Brunetto, Maurizia Rossana, and Gaeta, Giovanni Battista

Published
2024
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2. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Pasulo, Luisa, Coppola, Carmine, Pisano, Federica, Romano, Mariarosaria, Porcu, Carmen, Bottalico, Irene Francesca, Cossiga, Valentina, Tata, Xhimi, Sagnelli, Caterina, Pierotti, Piera, Degasperi, Elisabetta, Rosato, Valerio, Badia, Lorenzo, Ieluzzi, Dontella, Monti, Monica, Bavetta, Maria Grazia, Cavalletto, Luisa, Toniutto, Pierluigi, Fornasiere, Ezio, Colecchia, Antonio, Ferrarese, Alberto, Nardone, Gerardo, Rocco, Alba, Viganò, Mauro, Foschi, Francesco Giuseppe, Conti, Fabio, Morsica, Giulia, Salpietro, Stefania, Torti, Carlo, Costa, Chiara, Federico, Alessandro, Dallio, Marcello, Giorgini, Alessia, Anselmo, Marco, De Leo, Pasqualina, Zaltron, Serena, Cambianica, Anna, Piscaglia, Fabio, Serio, Ilaria, Schivazappa, Simona, Mastroianni, Antonio, Chidichimo, Luciana, Massari, Marco, Mazzaro, Cesare, Marrone, Aldo, D'Amore, Francesca Maria, D'Offizi, Gianpiero, Licata, Anna, Niro, Grazia Anna, Pollicino, Teresa, Aghemo, Alessio, Brancaccio, Giuseppina, Coco, Barbara, Nardi, Alessandra, Quaranta, Maria Giovanna, Tosti, Maria Elena, Ferrigno, Luigina, Cacciola, Irene, Messina, Vincenzo, Chessa, Luchino, Morisco, Filomena, Milella, Michele, Barbaro, Francesco, Ciancio, Alessia, Russo, Francesco Paolo, Coppola, Nicola, Blanc, Pierluigi, Claar, Ernesto, Verucchi, Gabriella, Puoti, Massimo, Zignego, Anna Linda, Chemello, Liliana, Madonia, Salvatore, Fagiuoli, Stefano, Marzano, Alfredo, Ferrari, Carlo, Lampertico, Pietro, Di Marco, Vito, Craxì, Antonio, Santantonio, Teresa Antonia, Raimondo, Giovanni, Brunetto, Maurizia R., Gaeta, Giovanni Battista, and Kondili, Loreta A.

Published
2023
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3. WED-446 Safety of direct-acting antivirals for hepatitis C infection and direct oral anticoagulants co-administration: an italian multicentric study

Author

Rosato, Valerio, primary, Dallio, Marcello, additional, Spinetti, Angiola, additional, Ciancio, Alessia, additional, Milella, Michele, additional, Colombatto, Piero, additional, D'Adamo, Giuseppe, additional, Del Turco, Elena Rosselli, additional, Gallo, Paolo, additional, Pugliese, Nicola, additional, D'Ambrosio, Roberta, additional, Colella, Elisa, additional, Brunetto, Maurizia, additional, Falcomatà, Andrea, additional, Vespasiani-Gentilucci, Umberto, additional, De Nicola, Stella, additional, Aghemo, Alessio, additional, Lampertico, Pietro, additional, Soria, Alessandro, additional, Izzi, Antonio, additional, Federico, Alessandro, additional, Mastrocinque, Davide, additional, and Claar, Ernesto, additional

Published
2024
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4. Safety of Sofosbuvir-Based Direct-Acting Antivirals for Hepatitis C Virus Infection and Direct Oral Anticoagulant Co-Administration.

Author

Rosato, Valerio, Nevola, Riccardo, Dallio, Marcello, Di Micco, Pierpaolo, Spinetti, Angiola, Zeneli, Laert, Ciancio, Alessia, Milella, Michele, Colombatto, Piero, D'Adamo, Giuseppe, Rosselli Del Turco, Elena, Gallo, Paolo, Falcomatà, Andrea, De Nicola, Stella, Pugliese, Nicola, D'Ambrosio, Roberta, Soria, Alessandro, Colella, Elisa, Federico, Alessandro, and Brunetto, Maurizia

Subjects
*ANTICOAGULANTS, *ORAL medication, *HEPATITIS C virus, *ANTIVIRAL agents, *CYTOCHROME P-450
Abstract

Background: Direct oral anticoagulants (DOACs) are recommended for the management of thrombosis prophylaxis, especially in patients with atrial fibrillation. As substrates of cytochrome P450 (CYP) 3A4 and/or P-glycoprotein, they are implicated in potential drug–drug interactions. NS5A/NS5B inhibitors are direct-acting agents (DAAs) against the Hepatitis C Virus (HCV) infection that exert a mild inhibition of P-glycoprotein without effects on CYP3A4. A DOAC and NS5A/NS5B inhibitor co-administration may lead to an increased risk of bleeding. Real-world data on the concomitant use of DOACs and DAAs are scarce. On this purpose, we perform a retrospective analysis on the risk of vascular adverse events (bleeding and thrombosis) among HCV patients under DOAC/DAA therapy, even in advanced liver disease. Methods: Between May 2015 and April 2023, patients treated with sofosbuvir-based DAA regimens and DOACs were consecutively included in this study from 12 Italian medical centers. Baseline characteristics, especially concerning bleeding risk and liver function, were collected. The occurrence of bleeding events, classified as major and minor, was the primary endpoint. Secondary endpoints were the rate of any thrombotic events and/or the need for discontinuation of one or both treatments. Moreover, a cohort of patients, matched by demographic characteristics (age and sex), that switched to vitamin K antagonists (VKAs) during the antiviral treatment was compared with the DOAC/DAA group. Results: A total of 104 patients were included. Thirty-eight of them (36.5%) were cirrhotic. Atrial fibrillation was an indication for anticoagulation in almost all cases (76%). Rivaroxaban (35.6%) was the most used DOAC, followed by apixaban (26.9%), dabigatran (19.2%) and edoxaban (18.3%). Sofosbuvir/velpatasvir (78.8%) was the most prescribed DAA, and all patients were already on anticoagulant therapy before the start of DAAs. During concomitant DOAC/DAA treatment, no major bleeding events were recorded, while four minor bleeding events occurred, but none resulted in DAA or DOAC discontinuation. At univariate analysis, the only additional risk factor statistically related to bleeding events was the anticoagulant therapy (hazard ratio [HR]: 13.2, 95% confidence interval 1,6-109). Performing an evaluation by a LOGIT binomial analysis with demographic characteristics, the antiplatelet therapy remained statistically associated to bleeding events. No significant differences were found in the rate of clinically relevant bleeding when the main population was compared with the VKA-switched cohort. A single major bleeding event leading to anticoagulation and DAA discontinuation was reported in VKA-switched matched cohort. Conclusions: In our study, the concomitant use of NS5A/NS5B inhibitors with DOAC showed good safety, and the only risk factor associated with bleeding events was the concomitant antiplatelet therapy. These findings support the use of DOACs during sofosbuvir-based HCV treatment, even in advanced liver disease. Replacing DOACs with VKAs does not appear to be of clinical benefit. [ABSTRACT FROM AUTHOR]

Published
2024
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5. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and Delta cohort

Author

Kondili, Loreta A., primary, Brancaccio, Giuseppina, additional, Tosti, Maria Elena, additional, Coco, Barbara, additional, Quaranta, Maria Giovanna, additional, Messina, Vincenzo, additional, Ciancio, Alessia, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, Ciarallo, Marianna, additional, Cacciola, Irene, additional, Ponziani, Francesca Romana, additional, Cerrito, Lucia, additional, Coppola, Roberta, additional, Longobardi, Francesco, additional, Biliotti, Elisa, additional, Rianda, Alessia, additional, Barbaro, Francesco, additional, Coppola, Nicola, additional, Stanzione, Maria, additional, Barchiesi, Francesco, additional, Fagiuoli, Stefano, additional, Viganò, Mauro, additional, Massari, Marco, additional, Russo, Francesco Paolo, additional, Ferrarese, Alberto, additional, Laccabue, Diletta, additional, Marco, Vito Di, additional, Blanc, Pierluigi, additional, Marrone, Aldo, additional, Morsica, Giulia, additional, Federico, Alessandro, additional, Ieluzzi, Donatella, additional, Rocco, Alba, additional, Foschi, Francesco Giuseppe, additional, Soria, Alessandro, additional, Maida, Ivana, additional, Chessa, Luchino, additional, Milella, Michele, additional, Turco, Elena Rosselli del, additional, Madonia, Salvatore, additional, Chemello, Liliana, additional, Gentile, Ivan, additional, Toniutto, Pierluigi, additional, Bassetti, Matteo, additional, Surace, Lorenzo, additional, Baiocchi, Leonardo, additional, Pellicelli, Adriano, additional, De Santis, Adriano, additional, Puoti, Massimo, additional, Degasperi, Elisabetta, additional, Niro, Grazia Anna, additional, Zignego, Anna Linda, additional, Craxi, Antonio, additional, Raimondo, Giovanni, additional, Santantonio, Teresa Antonia, additional, Brunetto, Maurizia Rossana, additional, Gaeta, Giovanni Battista, additional, and Investigators, on behalf of PITER Collaborating, additional

Published
2024
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6. Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

Author

Nevola, Riccardo, primary, Tortorella, Giovanni, additional, Rosato, Valerio, additional, Rinaldi, Luca, additional, Imbriani, Simona, additional, Perillo, Pasquale, additional, Mastrocinque, Davide, additional, La Montagna, Marco, additional, Russo, Antonio, additional, Di Lorenzo, Giovanni, additional, Alfano, Maria, additional, Rocco, Maria, additional, Ricozzi, Carmen, additional, Gjeloshi, Klodian, additional, Sasso, Ferdinando Carlo, additional, Marfella, Raffaele, additional, Marrone, Aldo, additional, Kondili, Loreta Anesti, additional, Esposito, Nicolino, additional, Claar, Ernesto, additional, and Cozzolino, Domenico, additional

Published
2023
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7. Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Tosti, Maria Elena, additional, Quaranta, Maria Giovanna, additional, Ciancio, Alessia, additional, Messina, Vincenzo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Capasso, Mario, additional, Rosato, Valerio, additional, Cacciola, Irene, additional, Pasulo, Luisa, additional, Santantonio, Teresa, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Barbaro, Francesco, additional, Massari, Marco, additional, Coppola, Nicola, additional, Ferrarese, Alberto, additional, Russo, Francesco Paolo, additional, Di Marco, Vito, additional, Marrone, Aldo, additional, Schivazappa, Simona, additional, Federico, Alessandro, additional, Blanc, Pierluigi, additional, Rocco, Alba, additional, Morsica, Giulia, additional, Ieluzzi, Donatella, additional, Conti, Fabio, additional, De Siena, Martina, additional, Bavetta, Maria Grazia, additional, Milella, Michele, additional, Gentile, Ivan, additional, Porcu, Carmen, additional, Chemello, Liliana, additional, Maracci, Monia, additional, Zignego, Anna Linda, additional, Baiocchi, Leonardo, additional, Maida, Ivana Rita, additional, and Coco, Barbara, additional

Published
2023
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8. Efficacy and safety of lusutrombopag in a real-world Italian series of cirrhotic patients with severe thrombocytopenia undergoing invasive procedures: the Reality study

Author

Gallo, Paolo, primary, De Vincentis, Antonio, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Vignone, Anthony, additional, Alvaro, Domenico, additional, Tortora, Raffaella, additional, Biolato, Marco, additional, Pompili, Maurizio, additional, Calvaruso, Vincenza, additional, Veneziano, Marzia, additional, Rosato, Valerio, additional, Claar, Ernesto, additional, Villani, Rosanna, additional, Izzi, Antonio, additional, Cozzolongo, Raffaele, additional, Distefano, Marco, additional, Messina, Vincenzo, additional, Ragone, Enrico, additional, Sacco, Rodolfo, additional, Cacciatore, Pierluigi, additional, Moretti, Alessandra, additional, Terracciani, Francesca, additional, Picardi, Antonio, additional, and Gentilucci, Umberto Vespasiani, additional

Published
2023
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11. Neoadjuvant and Adjuvant Systemic Therapies in Loco-Regional Treatments for Hepatocellular Carcinoma: Are We at the Dawn of a New Era?

Author

Nevola, Riccardo, primary, Delle Femine, Augusto Delle, additional, Rosato, Valerio, additional, Kondili, Loreta Anesti, additional, Alfano, Maria, additional, Mastrocinque, Davide, additional, Imbriani, Simona, additional, Perillo, Pasquale, additional, Beccia, Domenico, additional, Villani, Angela, additional, Ruocco, Rachele, additional, Criscuolo, Livio, additional, La Montagna, Marco La, additional, Russo, Antonio, additional, Marrone, Aldo, additional, Sasso, Ferdinando Carlo, additional, Marfella, Raffaele, additional, Rinaldi, Luca, additional, Esposito, Nicolino, additional, Barberis, Giuseppe, additional, and Claar, Ernesto, additional

Published
2023
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12. HBV Infection and Host Interactions: The Role in Viral Persistence and Oncogenesis

Author

Nevola, Riccardo, primary, Beccia, Domenico, additional, Rosato, Valerio, additional, Ruocco, Rachele, additional, Mastrocinque, Davide, additional, Villani, Angela, additional, Perillo, Pasquale, additional, Imbriani, Simona, additional, Delle Femine, Augusto, additional, Criscuolo, Livio, additional, Alfano, Maria, additional, La Montagna, Marco, additional, Russo, Antonio, additional, Marfella, Raffaele, additional, Cozzolino, Domenico, additional, Sasso, Ferdinando Carlo, additional, Rinaldi, Luca, additional, Marrone, Aldo, additional, Adinolfi, Luigi Elio, additional, and Claar, Ernesto, additional

Published
2023
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13. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Brancaccio, Giuseppina, primary, Coco, Barbara, additional, Nardi, Alessandra, additional, Quaranta, Maria Giovanna, additional, Tosti, Maria Elena, additional, Ferrigno, Luigina, additional, Cacciola, Irene, additional, Messina, Vincenzo, additional, Chessa, Luchino, additional, Morisco, Filomena, additional, Milella, Michele, additional, Barbaro, Francesco, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Coppola, Nicola, additional, Blanc, Pierluigi, additional, Claar, Ernesto, additional, Verucchi, Gabriella, additional, Puoti, Massimo, additional, Zignego, Anna Linda, additional, Chemello, Liliana, additional, Madonia, Salvatore, additional, Fagiuoli, Stefano, additional, Marzano, Alfredo, additional, Ferrari, Carlo, additional, Lampertico, Pietro, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Santantonio, Teresa Antonia, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Gaeta, Giovanni Battista, additional, Kondili, Loreta A., additional, Pasulo, Luisa, additional, Coppola, Carmine, additional, Pisano, Federica, additional, Romano, Mariarosaria, additional, Porcu, Carmen, additional, Bottalico, Irene Francesca, additional, Cossiga, Valentina, additional, Tata, Xhimi, additional, Sagnelli, Caterina, additional, Pierotti, Piera, additional, Degasperi, Elisabetta, additional, Rosato, Valerio, additional, Badia, Lorenzo, additional, Ieluzzi, Dontella, additional, Monti, Monica, additional, Bavetta, Maria Grazia, additional, Cavalletto, Luisa, additional, Toniutto, Pierluigi, additional, Fornasiere, Ezio, additional, Colecchia, Antonio, additional, Ferrarese, Alberto, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Viganò, Mauro, additional, Foschi, Francesco Giuseppe, additional, Conti, Fabio, additional, Morsica, Giulia, additional, Salpietro, Stefania, additional, Torti, Carlo, additional, Costa, Chiara, additional, Federico, Alessandro, additional, Dallio, Marcello, additional, Giorgini, Alessia, additional, Anselmo, Marco, additional, De Leo, Pasqualina, additional, Zaltron, Serena, additional, Cambianica, Anna, additional, Piscaglia, Fabio, additional, Serio, Ilaria, additional, Schivazappa, Simona, additional, Mastroianni, Antonio, additional, Chidichimo, Luciana, additional, Massari, Marco, additional, Mazzaro, Cesare, additional, Marrone, Aldo, additional, D'Amore, Francesca Maria, additional, D'Offizi, Gianpiero, additional, Licata, Anna, additional, Niro, Grazia Anna, additional, Pollicino, Teresa, additional, and Aghemo, Alessio, additional

Published
2023
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16. TOP-085 Final results from the italian real-world experience on lusutrombopag treatment in cirrhotic patients with severe thrombocytopenia: insights from the reality study

Author

Gallo, Paolo, De Vincentis, Antonio, Pace Palitti, Valeria, Russello, Maurizio, Vignone, Anthony, Alvaro, Domenico, Tortora, Raffaella, biolato, marco, Pompili, Maurizio, Calvaruso, Vincenza, Veneziano, Marzia, Tizzani, Marco, Frigo, Francesco, Caneglias, Alessandro, Marcantonio, Gesualdo, Marzano, Alfredo, Rosato, Valerio, Claar, Ernesto, Villani, Rosanna, Izzi, Antonio, Cozzolongo, Raffaele, Airoldi, Aldo, Mazzarelli, Chiara, Distefano, Marco, Iegri, Claudia, Fagiuoli, Stefano, Messina, Vincenzo, Ragone, Enrico, Sacco, Rodolfo, Cacciatore, Pierluigi, Masutti, Flora, Saveria Crocè, Lory, Moretti, Alessandra, Terracciani, Francesca, Falcomata, Andrea, Di Pasquale, Giulia, Flagiello, Valentina, Picardi, Antonio, and Vespasiani-Gentilucci, Umberto

Published
2024
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17. Can Telemedicine Optimize the HCV Care Cascade in People Who Use Drugs? Features of an Innovative Decentralization Model and Comparison with Other Micro-Elimination Strategies

Author

Nevola, Riccardo, primary, Rosato, Valerio, additional, Conturso, Vincenza, additional, Perillo, Pasquale, additional, Le Pera, Teresa, additional, Del Vecchio, Ferdinando, additional, Mastrocinque, Davide, additional, Pappalardo, Annalisa, additional, Imbriani, Simona, additional, Delle Femine, Augusto, additional, Piacevole, Alessia, additional, and Claar, Ernesto, additional

Published
2022
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18. Telemedicine Improves HCV Elimination among Italian People Who Use Drugs: An Innovative Therapeutic Model to Increase the Adherence to Treatment into Addiction Care Centers Evaluated before and during the COVID-19 Pandemic

Author

Rosato, Valerio, primary, Nevola, Riccardo, additional, Conturso, Vincenza, additional, Perillo, Pasquale, additional, Mastrocinque, Davide, additional, Pappalardo, Annalisa, additional, Le Pera, Teresa, additional, Del Vecchio, Ferdinando, additional, and Claar, Ernesto, additional

Published
2022
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20. Epidemiology of HCV and HBV in a High Endemic Area of Southern Italy: Opportunities from the COVID-19 Pandemic—Standardized National Screening or One Tailored to Local Epidemiology?

Author

Nevola, Riccardo, primary, Messina, Vincenzo, additional, Marrone, Aldo, additional, Coppola, Nicola, additional, Rescigno, Carolina, additional, Esposito, Vincenzo, additional, Sangiovanni, Vincenzo, additional, Claar, Ernesto, additional, Pisaturo, Mariantonietta, additional, Fusco, Francesco Maria, additional, Rosario, Pietro, additional, Izzi, Antonio, additional, Pisapia, Raffaella, additional, Rosato, Valerio, additional, Maggi, Paolo, additional, and Adinolfi, Luigi Elio, additional

Published
2022
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21. Factors affecting long‐term changes of liver stiffness in direct‐acting anti‐hepatitis C virus therapy: A multicentre prospective study

Author

Rosato, Valerio, primary, Ascione, Antonio, additional, Nevola, Riccardo, additional, Fracanzani, Anna Ludovica, additional, Piai, Guido, additional, Messina, Vincenzo, additional, Claar, Ernesto, additional, Coppola, Carmine, additional, Fontanella, Luca, additional, Lombardi, Rosa, additional, Staiano, Laura, additional, Valente, Giovanna, additional, Fascione, Maria Chiara, additional, Giorgione, Chiara, additional, Mazzocca, Annalisa, additional, Galiero, Raffaele, additional, Perillo, Pasquale, additional, Marrone, Aldo, additional, Sasso, Ferdinando Carlo, additional, Adinolfi, Luigi Elio, additional, and Rinaldi, Luca, additional

Published
2021
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24. WED-146 - Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, Tosti, Maria Elena, Quaranta, Maria Giovanna, Ciancio, Alessia, Messina, Vincenzo, Brancaccio, Giuseppina, Brunetto, Maurizia, Capasso, Mario, Rosato, Valerio, Cacciola, Irene, Pasulo, Luisa, Santantonio, Teresa, Coppola, Carmine, Biliotti, Elisa, Barbaro, Francesco, Massari, Marco, Coppola, Nicola, Ferrarese, Alberto, Russo, Francesco Paolo, Di Marco, Vito, Marrone, Aldo, Schivazappa, Simona, Federico, Alessandro, Blanc, Pierluigi, Rocco, Alba, Morsica, Giulia, Ieluzzi, Donatella, Conti, Fabio, De Siena, Martina, Bavetta, Maria Grazia, Milella, Michele, Gentile, Ivan, Porcu, Carmen, Chemello, Liliana, Maracci, Monia, Zignego, Anna Linda, Baiocchi, Leonardo, Maida, Ivana Rita, and Coco, Barbara

Published
2023
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25. OS-036 - Efficacy and safety of lusutrombopag in a real-world Italian series of cirrhotic patients with severe thrombocytopenia undergoing invasive procedures: the Reality study

Author

Gallo, Paolo, De Vincentis, Antonio, Palitti, Valeria Pace, Russello, Maurizio, Vignone, Anthony, Alvaro, Domenico, Tortora, Raffaella, Biolato, Marco, Pompili, Maurizio, Calvaruso, Vincenza, Veneziano, Marzia, Rosato, Valerio, Claar, Ernesto, Villani, Rosanna, Izzi, Antonio, Cozzolongo, Raffaele, Distefano, Marco, Messina, Vincenzo, Ragone, Enrico, Sacco, Rodolfo, Cacciatore, Pierluigi, Moretti, Alessandra, Terracciani, Francesca, Picardi, Antonio, and Gentilucci, Umberto Vespasiani

Published
2023
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26. Factors Enhancing Treatment of Hepatitis C Virus–Infected Italian People Who Use Drugs: The CLEO-GRECAS Experience

Author

Rinaldi, Luca, primary, Messina, Vincenzo, additional, Di Marco, Vito, additional, Iovinella, Vincenzo, additional, Claar, Ernesto, additional, Cariti, Giuseppe, additional, Sacco, Rodolfo, additional, De Luca, Massimo, additional, Scifo, Gaetano, additional, Gatti, Pietro, additional, Barbarini, Giorgio, additional, Pace Palitti, Valeria, additional, Quartini, Mariano, additional, Tundo, Paolo, additional, D'Offizi, Gianpiero, additional, Parruti, Giustino, additional, di Rosolini, Maria Antonietta, additional, Garrucciu, Giovanni, additional, Cosco, Lucio, additional, Benanti, Francesco, additional, Gimignani, Giancarlo, additional, Vespasiani Gentilucci, Umberto, additional, Di Lorenzo, Francesco, additional, D'Antò, Maria, additional, Nevola, Riccardo, additional, Lupia, Tommaso, additional, Rosato, Valerio, additional, Morbiducci, Valeria, additional, Luzzitelli, Ilaria, additional, Sozio, Federica, additional, Di Stefano, Marco, additional, Ciraci, Emanuela, additional, Bulla, Fabio, additional, Guarisco, Riccardo, additional, Cangiano, Cecilia, additional, Imparato, Michele, additional, Maggi, Paolo, additional, Ascione, Antonio, additional, Craxì, Antonio, additional, and Izzi, Antonio, additional

Published
2021
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27. Directly Acting Antiviral-Based Treatment for HCV-Infected Persons Who Inject Drugs: A Multicenter Real-Life Study

Author

Messina, Vincenzo, primary, Onorato, Lorenzo, additional, Di Caprio, Giovanni, additional, Claar, Ernesto, additional, Iovinella, Vincenzo, additional, Russo, Antonio, additional, Rosato, Valerio, additional, Salzillo, Angela, additional, Nevola, Riccardo, additional, Simeone, Filomena, additional, Curcio, Fabio, additional, Pisaturo, Mariantonietta, additional, and Coppola, Nicola, additional

Published
2020
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30. Effectiveness of new generation DAAs for HCV infection in a large cohort of Italian people who use drugs (PWID): the cleo-grecas real-world experience

Author

Messina, Vincenzo, primary, Iovinella, Vincenzo, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, De Luca, Massimo, additional, Barbarini, Giorgio, additional, Cariti, Giuseppe, additional, Lupia, Tommaso, additional, Quartini, Mariano, additional, D’Offizi, Gianpiero, additional, Luzzitelli, Ilaria, additional, Parruti, Giustino, additional, Sozio, Federica, additional, Scifo, Gaetano, additional, Distefano, Marco, additional, Paolo, Tundo, additional, Benanti, Francesco, additional, Cosco, Lucio, additional, Bulla, Fabio, additional, Gimignani, Giancarlo, additional, Di Rosolini, Maria Antonietta, additional, Palitti, Valeria Pace, additional, Gentilucci, Umberto Vespasiani, additional, Ascione, Antonio, additional, Imparato, Michele, additional, Rinaldi, Luca, additional, Nevola, Riccardo, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Morbiducci, Valeria, additional, Di Lorenzo, Francesco, additional, Guarisco, Riccardo, additional, Sacco, Rodolfo, additional, and Izzi, Antonio, additional

Published
2020
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31. Long-term evaluation of liver stiffness in HCV patients after sustained virological response to DAAs: predictive factors for disease improvement and hepatocellular carcinoma development

Author

Nevola, Riccardo, primary, Rosato, Valerio, additional, Claar, Ernesto, additional, Coppola, Carmine, additional, fontanella, luca, additional, Fracanzani, Anna Ludovica, additional, Piai, Guido, additional, Valente, Giovanna, additional, Ascione, Antonio, additional, Lombardi, Rosa, additional, Saturnino, Mariarosaria, additional, Staiano, Laura, additional, Perillo, Pasquale, additional, Pafundi, Pia Clara, additional, Marrone, Aldo, additional, Sasso, Ferdinando Carlo, additional, Adinolfi, Luigi Elio, additional, and Rinaldi, Luca, additional

Published
2020
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32. Unusual liver‐related heart injury

Author

Nevola, Riccardo, primary, Rosato, Valerio, additional, Perillo, Pasquale, additional, Esposito, Nicolino, additional, Massa, Domenico, additional, Frascino, Anna Maria, additional, Capurro, Vittorio, additional, and Claar, Ernesto, additional

Published
2020
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34. Factors affecting long‐term changes of liver stiffness in direct‐acting anti‐hepatitis C virus therapy: A multicentre prospective study.

Author

Rosato, Valerio, Ascione, Antonio, Nevola, Riccardo, Fracanzani, Anna Ludovica, Piai, Guido, Messina, Vincenzo, Claar, Ernesto, Coppola, Carmine, Fontanella, Luca, Lombardi, Rosa, Staiano, Laura, Valente, Giovanna, Fascione, Maria Chiara, Giorgione, Chiara, Mazzocca, Annalisa, Galiero, Raffaele, Perillo, Pasquale, Marrone, Aldo, Sasso, Ferdinando Carlo, and Adinolfi, Luigi Elio

Subjects
*FATTY liver, *LONGITUDINAL method, *LIVER, *RECEIVER operating characteristic curves, *MULTIVARIATE analysis, *HEPATITIS C, *LONG-term care facilities
Abstract

The long‐term changes of liver stiffness (LS) in patients who achieve viral clearance after direct‐acting anti‐HCV therapy remain undefined. We conducted a multicentre prospective study to investigate this aspect. Patients with HCV infection treated with DAAs were enrolled from six Italian centres; they underwent clinical, biochemical, ultrasound and transient elastography evaluations before treatment (T0), 12 weeks (SVR12) and 24 months (T24) after the end of therapy. Among the 516 consecutive patients enrolled, 301 had cirrhosis. LS significantly decreased from T0 to SVR (14.3 vs 11.1 kPa, p =.002), with a progressive reduction until T24 (8.7 kPa, p <.001). However, only patients with steatosis and those who developed HCC did not experience a late improvement in LS. Multivariate analysis of baseline and follow‐up variables identified steatosis as the only independent predictor of failure of LS improvement (OR 1.802, p =.013). ROC curve analysis of the association of LS with the risk of developing HCC showed that SVR12 ≥14.0 kPa had the highest accuracy (sensitivity 82%, specificity 99%; AUC: 0.774). Multivariate analysis revealed that LS was the only variable independently associated with an increased risk of developing HCC (OR 6.470, p =.035). Achieving an SVR was associated with a progressive, long‐term decline of LS, suggesting a late improvement in liver fibrosis, besides the resolution of inflammation. Fatty liver and the development of HCC interfered with late reduction of LS. Patients with an LS ≥14 kPa at 12 weeks after the end of treatment were at higher risk for developing HCC. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

Author

Masarone, Mario, Rosato, Valerio, Dallio, Marcello, Gravina, Antonietta Gerarda, Aglitti, Andrea, Loguercio, Carmelina, Federico, Alessandro, and Persico, Marcello

Subjects
Article Subject
Abstract

Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a “multiple parallel-hit model,” in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage. The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD. With this aim, we evaluated the available data in basic science and clinical studies in this field, reviewing the most recent works published on this topic.

Published
2018
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36. Vascular Endothelial Dysfunction in Inflammatory Bowel Diseases: Pharmacological and Nonpharmacological Targets

Author

Gravina, Antonietta Gerarda, Dallio, Marcello, Masarone, Mario, Rosato, Valerio, Aglitti, Andrea, Persico, Marcello, Loguercio, Carmelina, and Federico, Alessandro

Subjects
Article Subject
Abstract

Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are chronic inflammatory conditions involving primarily the gastrointestinal tract. However, they may be also associated with systemic manifestations and comorbidities. The relationship between chronic inflammation and endothelial dysfunction has been extensively demonstrated. Mucosal immunity and gastrointestinal physiology are modified in inflammatory bowel diseases, and these modifications are mainly sustained by alterations of endothelial function. The key elements involved in this process are cytokines, inflammatory cells, growth factors, nitric oxide, endothelial adhesion molecules, and coagulation cascade factors. In this review, we discuss available data in literature concerning endothelial dysfunction in patients affected by inflammatory bowel disease and we focus our attention on both pharmacological and nonpharmacological therapeutic targets.

Published
2018
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38. Real‐life glecaprevir/pibrentasvir in a large cohort of patients with hepatitis C virus infection: The MISTRAL study

Author

Persico, Marcello, primary, Aglitti, Andrea, additional, Milella, Michele, additional, Coppola, Carmine, additional, Messina, Vincenzo, additional, Claar, Ernesto, additional, Gentile, Ivan, additional, Sogari, Fernando, additional, Pierri, Paola, additional, Surace, Lorenzo A., additional, Morisco, Filomena, additional, Tundo, Paolo, additional, Brancaccio, Giuseppina, additional, Serviddio, Gaetano, additional, Gatti, Pietro, additional, Termite, Antonio P., additional, Di Costanzo, Giovan G., additional, Caroleo, Benedetto, additional, Cozzolongo, Raffaele, additional, Coppola, Nicola, additional, Longo, Annamaria, additional, Fontanella, Luca, additional, Federico, Alessandro, additional, Rosato, Valerio, additional, Terrenato, Irene, additional, and Masarone, Mario, additional

Published
2019
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42. Lactate determination in pleural and abdominal effusions: a quick diagnostic marker of exudate—a pilot study

Author

Porta, Giovanni, primary, Numis, Fabio G., additional, Rosato, Valerio, additional, Pagano, Antonio, additional, Masarone, Mario, additional, Bosso, Giorgio, additional, Serra, Claudia, additional, Rinaldi, Luca, additional, Fascione, Maria C., additional, Amelia, Annalisa, additional, Paladino, Fiorella, additional, and Schiraldi, Fernando, additional

Published
2017
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45. Sustained Virological Response by Direct Antiviral Agents in HCV Leads to an Early and Significant Improvement of Liver Fibrosis

Author

Persico, Marcello, primary, Rosato, Valerio, additional, Aglitti, Andrea, additional, Precone, Davide, additional, Corrado, Mariano, additional, Luna, Antonio De, additional, Morisco, Filomena, additional, Camera, Silvia, additional, Federico, Alessandro, additional, Dallio, Marcello, additional, Claar, Ernesto, additional, Caporaso, Nicola, additional, and Masarone, Mario, additional

Published
2017
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46. Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis

Author

Rinaldi, Luca, primary, Nascimbeni, Fabio, additional, Giordano, Mauro, additional, Masetti, Chiara, additional, Guerrera, Barbara, additional, Amelia, Annalisa, additional, Fascione, Maria Chiara, additional, Ballestri, Stefano, additional, Romagnoli, Dante, additional, Zampino, Rosa, additional, Nevola, Riccardo, additional, Baldelli, Enrica, additional, Iuliano, Natalina, additional, Rosato, Valerio, additional, Lonardo, Amedeo, additional, and Adinolfi, Luigi Elio, additional

Published
2017
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47. Impact of Telaprevir in HCV Patients with Cirrhosis and RVR: Real-Life Data from Boceprevir or Telaprevir based “Triple Therapy” Experience in Southern Italy

Author

Morisco, Filomena, primary, Masarone, Mario, additional, Rosato, Valerio, additional, Camera, Silvia, additional, Granata, Rocco, additional, Tartaglione, Maria, additional, Coppola, Carmine, additional, Coppola, Nicola, additional, Salomone-Megna, Angelo, additional, Gentile, Ivan, additional, Luna, Antonio, additional, Federico, Alessandro, additional, Precone, Davide, additional, Claar, Ernesto, additional, Abenavoli, Ludovico, additional, and Persico, Marcello, additional

Published
2016
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