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Byline: Harini. Bala, Jennifer. Nguyen, Angelique. Ross, Celestine. Wong, Eldho. Paul, Michelle. Rodrigues Sir, Melasma is a complex and therapeutically challenging condition for dermatologists globally. Oral tranexamic acid (TA), first [...]

Melasma is a common disorder of hyperpigmentation that presents a therapeutic challenge for clinical dermatologists. The pathogenesis is complex, but previous studies have demonstrated vascular proliferation is a key factor in the development of the classic hyperpigmented patches. Studies have revealed reduction of erythema by oral tranexamic acid; however, there has been no direct comparison to placebo. This 24‐week randomised placebo‐controlled trial demonstrates oral tranexamic acid may improve erythema in melasma. This mechanism of action may be the reason for the success of tranexamic acid in complex and difficult to treat melasma. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 38-year-old woman presented with an 8-year history of reticulate hyperpigmentation involving the neck and trunk, with previous inflammatory papules. It discusses the Prurigo pigmentosa was clinically suspected and confirmed with punch biopsies. It notes the Oral erythromycin was initially used to treat the inflammation.