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5 results on '"Rossana Chiarabini"'

1. Direct antimicrobial susceptibility testing of Gram-negative bacteria from positive blood cultures

Author

Andrea Zappavigna, Enrica Cavatorta, Rossana Chiarabini, Roberta Schiavo, Daniela Padrini, Camilla Reboli, and Massimo Confalonieri

Subjects
Bacterial sensitivity test, Bacteraemia, Gram-negative bacteria, Blood culture., Microbiology, QR1-502
Abstract

Every year, a great number of people die for bloodstream infections, especially by too late or inappropriate pharmacological treatment. The principal laboratory test for this type of infections is the blood culture; its limit is a turnaround time of about 96 hours. The aim of this work was to compare direct susceptibility testing with the automated VITEK 2 system. Fifty blood cultures, positive for Gram-negative bacteria, were processed for amikacin, ciprofloxacin, ceftazidime, piperacillin-tazobactam, cefotaxime, meropenem and colistin with VITEK 2 and direct susceptibility testing by Kirby-Bauer or E-test methods. We found 93.7% correlation with 5.0% minor errors, 0.5% very major errors and 0.8% major errors. Piperacillin-tazobactam has shown the lowest percentage of correlation (79%) and the highest percentage of errors (21%). To conclude, direct susceptibility testing of positive blood cultures has shown promising results, rendering this method useful for giving to clinicians preliminary informations for therapy.

Published
2014
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2. Klebsiella pneumoniae: resistance to carbapenems carbapenemase-mediated in the area of Piacenza

Author

Massimo Confalonieri, Enrica Cavatorta, Camilla Reboli, Maria Milanda Bertelli, Rossana Chiarabini, Daniela Padrini, Francesca Riggio, Corrado Confalonieri, and Enrica Poggi

Subjects
Klebsiella pneumoniae, Carbapenemase, Phenotypic test., Microbiology, QR1-502
Abstract

The detection of Klebsiella pneumoniae isolates showing a reduced susceptibility or resistance to carbapenems represents an increasing problem. The aim of this study is to survey the presence of carbapenemases producing strains in our country. 22 isolates of K. pneumoniae isolates showing carbapenems MIC => 2 by Vitek 2 System, were collected in the period May-August 2010 and studied for carbapenemases production using phenotypic confirmatory tests. The modified Hodge test and the DD-sinergy test with boronic acid yelded positive results for 17/22 strains; all the isolates resulted negative to the E-test MBL (imipenem and imipenem/EDTA). The results of this study confirm the recent emergence of KPC-producing K. pneumoniae strains in the area of Piacenza.The phenotypic tests employed appear reliable and simple for the confirmation of carbapenemases-production in K. pneumonie.

Published
2010
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3. Risk factors for group B streptococcus early-onset disease: an Italian, area-based, case-control study

Author

Milena Azzalli, Laura Lucaccioni, Caterina Spada, Maria Federica Pedna, Mario Sarti, Agostino Barozzi, Simone Ambretti, Maria Letizia Bacchi Reggiani, Lorenzo Iughetti, Sara Fornaciari, Alberto Berardi, R Pagano, Rossana Chiarabini, Eleonora Vaccina, Angela Lanzoni, Icilio Dodi, and Roberta Creti

Subjects
medicine.medical_specialty, Disease, beta-Lactams, medicine.disease_cause, Group B, Streptococcus agalactiae, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, Prenatal Diagnosis, Streptococcal Infections, 030225 pediatrics, Internal medicine, medicine, Early-onset disease, GBS screening, group B streptococcus, intrapartum antibiotic prophylaxis, Humans, 030212 general & internal medicine, Pregnancy Complications, Infectious, Antibiotic prophylaxis, reproductive and urinary physiology, business.industry, Streptococcus, Incidence, Infant, Newborn, Case-control study, Obstetrics and Gynecology, Antibiotic Prophylaxis, Early onset disease, Infectious Disease Transmission, Vertical, Italy, Case-Control Studies, Pediatrics, Perinatology and Child Health, Female, business
Abstract

Purpose: Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcus (GBS) early-onset disease (EOD). No European study evaluates the relative impact of risk factors (RFs) for EOD after...

Published
2019
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4. Direct antimicrobial susceptibility testing of Gram-negative bacteria from positive blood cultures

Author

Daniela Padrini, Massimo Confalonieri, Enrica Cavatorta, Roberta Schiavo, Camilla Reboli, Andrea Zappavigna, and Rossana Chiarabini

Subjects
medicine.medical_specialty, Gram-negative bacteria, Cefotaxime, medicine.diagnostic_test, biology, lcsh:QR1-502, Ceftazidime, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Meropenem, lcsh:Microbiology, Microbiology, Ciprofloxacin, Bacterial sensitivity test, Bacteraemia, Gram-negative bacteria, Blood culture, Amikacin, Internal medicine, medicine, Colistin, polycyclic compounds, Blood culture, medicine.drug
Abstract

Every year, a great number of people die for bloodstream infections, especially by too late or inappropriate pharmacological treatment. The principal laboratory test for this type of infections is the blood culture; its limit is a turnaround time of about 96 hours. The aim of this work was to compare direct susceptibility testing with the automated VITEK 2 system. Fifty blood cultures, positive for Gram-negative bacteria, were processed for amikacin, ciprofloxacin, ceftazidime, piperacillin-tazobactam, cefotaxime, meropenem and colistin with VITEK 2 and direct susceptibility testing by Kirby-Bauer or E-test methods. We found 93.7% correlation with 5.0% minor errors, 0.5% very major errors and 0.8% major errors. Piperacillin-tazobactam has shown the lowest percentage of correlation (79%) and the highest percentage of errors (21%). To conclude, direct susceptibility testing of positive blood cultures has shown promising results, rendering this method useful for giving to clinicians preliminary informations for therapy.

Published
2014

5. Klebsiella pneumoniae: resistance to carbapenems carbapenemase-mediated in the area of Piacenza

Author

Rossana Chiarabini, Maria Milanda Bertelli, Enrica Cavatorta, Massimo Confalonieri, Corrado Confalonieri, Camilla Reboli, Francesca Riggio, Enrica Poggi, and Daniela Padrini

Subjects
Imipenem, Klebsiella pneumoniae, Klebsiella pneumoniae, Carbapenemase, Phenotypic test, lcsh:QR1-502, General Medicine, biochemical phenomena, metabolism, and nutrition, Biology, bacterial infections and mycoses, biology.organism_classification, Virology, lcsh:Microbiology, Microbiology, Reduced susceptibility, medicine, medicine.drug
Abstract

The detection of Klebsiella pneumoniae isolates showing a reduced susceptibility or resistance to carbapenems represents an increasing problem. The aim of this study is to survey the presence of carbapenemases producing strains in our country. 22 isolates of K. pneumoniae isolates showing carbapenems MIC => 2 by Vitek 2 System, were collected in the period May-August 2010 and studied for carbapenemases production using phenotypic confirmatory tests. The modified Hodge test and the DD-sinergy test with boronic acid yelded positive results for 17/22 strains; all the isolates resulted negative to the E-test MBL (imipenem and imipenem/EDTA). The results of this study confirm the recent emergence of KPC-producing K. pneumoniae strains in the area of Piacenza.The phenotypic tests employed appear reliable and simple for the confirmation of carbapenemases-production in K. pneumonie.

Published
2010
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