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4. Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona)

Author

Antinori, Andrea, Antinori, Spinello, Baiguera, Chiara, Baldin, Gianmaria, Bassetti, Matteo, Biasioli, Lorenzo, Bonfanti, Paolo, Brucci, Giorgia, Bruzzesi, Elena, Candela, Caterina, Cascio, Antonio, Castagna, Antonella, Monforte, Antonella d'Arminio, Delama, Andrea, D'Ettorre, Gabriella, Farinacci, Damiano, Fusco, Francesco Maria, Gismondo, Maria Rita, Gori, Andrea, Lanini, Simone, Lanzafame, Massimiliano, Lapadula, Giuseppe, Lichtner, Miriam, Maci, Chiara, Mancarella, Giulia, Mancon, Alessandro, Marchetti, Giulia, Matusali, Giulia, Mazzotta, Valentina, Nicastri, Emanuele, Nozza, Silvia, Pandolfo, Alessandro, Panzo, Francesca, Piconi, Stefania, Pinnetti, Carmela, Pipitò, Luca, Raccagni, Angelo Roberto, Raimondi, Alessandro, Ridolfi, Marco, Rizzardini, Giuliano, Rodanò, Alessandra, Rossotti, Roberto, Sambo, Margherita, Sangiovanni, Vincenzo, Sangiovanni, Nadia, Tamburrini, Enrica, Tavelli, Alessandro, Tesoro, Daniele, Vita, Serena, Moschese, Davide, Mileto, Davide, Di Biagio, Antonio, and Monforte, Antonella d’Arminio

Published
2024
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5. Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy

Author

Cutrera, Miriam, Cuomo, Marianna, De Poli, Federica, Campanini, Giulia, Pitrolo, Antonino Maria Guglielmo, Iskandar, Elizabeth, Cassaniti, Irene, Bruno, Raffaele, Rizzardini, Giuliano, Puoti, Massimo, Castelli, Francesco, Corsico, Laura, Giacomelli, Andrea, Pozza, Giacomo, Casalini, Giacomo, Raccagni, Angelo, Trentacapilli, Bendetta, Bertoni, Costanza, Bruzzesi, Elena, Candela, Caterina, Tesoro, Daniele, Mule, Giovanni, Bandera, Alessandra, Bianca Mariani, Antonio Muscatello, Maffeo, Manuel, Vecchio, Riccardo, Piccinelli, Sara, Piralla, Antonio, Mileto, Davide, Rizzo, Alberto, Ferrari, Guglielmo, Giardina, Federica, Gaiarsa, Stefano, Petazzoni, Greta, Bianchi, Micol, Salari, Federica, Bracchitta, Fiorenza, Sammartino, Josè Camilla, Ferrari, Alessandro, Gagliardi, Gloria, Mancon, Alessandro, Fenizia, Claudio, Biasin, Mara, Rovida, Francesca, Paolucci, Stefania, Percivalle, Elena, Lombardi, Alessandra, Micheli, Valeria, Nozza, Silvia, Castagna, Antonella, Moschese, Davide, Antinori, Spinello, Gori, Andrea, Bonfanti, Paolo, Rossotti, Roberto, D'Arminio Monforte, Antonella, Attanasi, Federica, Tirani, Marcello, Cereda, Danilo, Baldanti, Fausto, and Gismondo, Maria Rita

Published
2024
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6. FRI-442 Disease progression and persistent alanine aminotransferase elevation in HCV/HIV persons after DAA-related eradication: role of HBV and HDV co-infections

Author

Rossotti, Roberto, primary, Tavelli, Alessandro, additional, Malagnino, Vincenzo, additional, Svicher, Valentina, additional, Quiros-Roldan, Eugenia, additional, Bandera, Alessandra, additional, Fusco, Francesco Maria, additional, Capparuccia, Marco Rivano, additional, Gaeta, Giovanni Battista, additional, Mazzotta, Valentina, additional, Puoti, Massimo, additional, and Monforte, Antonella D'Arminio, additional

Published
2024
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7. Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy

Author

Piralla, Antonio, primary, Mileto, Davide, additional, Rizzo, Alberto, additional, Ferrari, Guglielmo, additional, Giardina, Federica, additional, Gaiarsa, Stefano, additional, Petazzoni, Greta, additional, Bianchi, Micol, additional, Salari, Federica, additional, Bracchitta, Fiorenza, additional, Sammartino, Josè Camilla, additional, Ferrari, Alessandro, additional, Gagliardi, Gloria, additional, Mancon, Alessandro, additional, Fenizia, Claudio, additional, Biasin, Mara, additional, Rovida, Francesca, additional, Paolucci, Stefania, additional, Percivalle, Elena, additional, Lombardi, Alessandra, additional, Micheli, Valeria, additional, Nozza, Silvia, additional, Castagna, Antonella, additional, Moschese, Davide, additional, Antinori, Spinello, additional, Gori, Andrea, additional, Bonfanti, Paolo, additional, Rossotti, Roberto, additional, Monforte, Antonella D'arminio, additional, Attanasi, Federica, additional, Tirani, Marcello, additional, Cereda, Danilo, additional, Baldanti, Fausto, additional, Gismondo, Maria Rita, additional, Cutrera, Miriam, additional, Cuomo, Marianna, additional, De Poli, Federica, additional, Campanini, Giulia, additional, Pitrolo, Antonino Maria Guglielmo, additional, Iskandar, Elizabeth, additional, Cassaniti, Irene, additional, Bruno, Raffaele, additional, Rizzardini, Giuliano, additional, Puoti, Massimo, additional, Castelli, Francesco, additional, Corsico, Laura, additional, Giacomelli, Andrea, additional, Pozza, Giacomo, additional, Casalini, Giacomo, additional, Raccagni, Angelo, additional, Trentacapilli, Bendetta, additional, Bertoni, Costanza, additional, Bruzzesi, Elena, additional, Candela, Caterina, additional, Tesoro, Daniele, additional, Mule, Giovanni, additional, Bandera, Alessandra, additional, Bianca Mariani, Antonio Muscatello, additional, Maffeo, Manuel, additional, Vecchio, Riccardo, additional, and Piccinelli, Sara, additional

Published
2024
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9. Determinants of worse liver-related outcome according to HDV infection among HBsAg positive persons living with HIV: Data from the ICONA cohort

Author

d'Arminio Monforte, A, Tavelli, A, Salpini, R, Piermatteo, L, D'Anna, S, Carrara, S, Malagnino, V, Mazzotta, V, Brancaccio, G, Marchetti, G, Rosselli Del Turco, E, Rossotti, R, Mussini, C, Antinori, A, Lo Caputo, S, Ceccherini Silberstein, F, Gaeta, G, Svicher, V, Puoti, M, Bonfanti, P, Lapadula, G, d'Arminio Monforte, Antonella, Tavelli, Alessandro, Salpini, Romina, Piermatteo, Lorenzo, D'Anna, Stefano, Carrara, Stefania, Malagnino, Vincenzo, Mazzotta, Valentina, Brancaccio, Giuseppina, Marchetti, Giulia Carla, Rosselli Del Turco, Elena, Rossotti, Roberto, Mussini, Cristina, Antinori, Andrea, Lo Caputo, Sergio, Ceccherini Silberstein, Francesca, Gaeta, Giovanni Battista, Svicher, Valentina, Puoti, Massimo, Bonfanti, Paolo, Lapadula, Giuseppe, d'Arminio Monforte, A, Tavelli, A, Salpini, R, Piermatteo, L, D'Anna, S, Carrara, S, Malagnino, V, Mazzotta, V, Brancaccio, G, Marchetti, G, Rosselli Del Turco, E, Rossotti, R, Mussini, C, Antinori, A, Lo Caputo, S, Ceccherini Silberstein, F, Gaeta, G, Svicher, V, Puoti, M, Bonfanti, P, Lapadula, G, d'Arminio Monforte, Antonella, Tavelli, Alessandro, Salpini, Romina, Piermatteo, Lorenzo, D'Anna, Stefano, Carrara, Stefania, Malagnino, Vincenzo, Mazzotta, Valentina, Brancaccio, Giuseppina, Marchetti, Giulia Carla, Rosselli Del Turco, Elena, Rossotti, Roberto, Mussini, Cristina, Antinori, Andrea, Lo Caputo, Sergio, Ceccherini Silberstein, Francesca, Gaeta, Giovanni Battista, Svicher, Valentina, Puoti, Massimo, Bonfanti, Paolo, and Lapadula, Giuseppe

Abstract

Objectives: We aimed to study hepatitis D virus (HDV) prevalence and risk of progression to severe liver-related events (SLRE) in HBsAg positive people living with HIV (PLWH) in Italy; role of HDV-RNA copy levels, HCV coinfection and nadir CD4 counts were also investigated. Methods: People living with HIV (PLWH) from Italian Foundation cohort Naïve antiretrovirals (ICONA) with available HBsAg and HDV Ab were enrolled. HBsAg, HDV Ab, HDV-RNA and HDV genotypes were tested. Primary end-point: time from first HDV screening to Severe Liver Related Events (SLRE: decompensated cirrhosis, liver transplantation, HCC). Fine-grey regression models were used to evaluate the association of HDV Ab, HDV-RNA, HDV/HCV coinfection, CD4 nadir and outcome. Secondary end-points: time to SLRE or death; HDV Ab and HDV-RNA prevalence. Results: A total of 152/809 (18.8%) HBsAg positive PLWH showed HDV Ab reactivity; 63/93 (67.7%) were HDV-RNA positive. Being male, persons who inject drugs (PWID), HCV Ab positive, with FIB-4 > 3.25 were independent factors of HDV Ab positivity. In a median follow-up of 5 years, 37 PLWH (4.1% at 5-year) developed SLRE and 97 (12.0%) reached the SLRE or death end-point. HDV-RNA positive (independently from HDV-RNA copy level) PLWH had a 4.6-fold (95%CI 2.0–10.5) higher risk of SLRE than HDV negatives. PLWH positive for both HCV Ab and HDV Ab showed the highest independent risk of SLRE (ASHR: 11.9, 95%CI: 4.6–30.9 vs. HCV neg/HDV neg). Nadir CD4 < 200/mL was associated with SLRE (ASHR: 3.9, 95% 1.0–14.5). Conclusions: One-fifth of the HBsAg positive PLWH harbour HDV infection, and are at high risk of progression to advanced liver disease. HCV contributes to worse outcomes. This population needs urgently effective treatments.

Published
2024

10. Surge of Mpox cases in Lombardy region, Italy, October 2023 - January 2024

Author

Moschese, D, Raccagni, A, Giacomelli, A, Piralla, A, Rossotti, R, Raimondi, A, Tesoro, D, Vezzosi, L, Gulletta, M, Clementi, N, Venturelli, S, Benardon, S, Ricaboni, D, Bernacchia, D, Mancon, A, Rovida, F, Attanasi, F, Cereda, D, Gismondo, M, Gori, A, Rizzardini, G, Antinori, S, Baldanti, F, Marzano, A, Marchetti, G, Castelli, F, Castagna, A, Nozza, S, Mileto, D, Bonfanti, P, Biasioli, L, Bruno, R, Vittoria Cossu, M, Fusetti, C, Lazzarin, S, Locatelli, M, Morosi, M, Piscaglia, M, Pusterla, L, Pozza, G, Ramoni, S, Rusconi, S, Rizzi, M, Rizzo, A, Sabaini, F, Salari, F, Sampaolo, M, Puoti, M, Tirani, M, Rachele Tomasoni, L, Moschese, Davide, Raccagni, Angelo Roberto, Giacomelli, Andrea, Piralla, Antonio, Rossotti, Roberto, Raimondi, Alessandro, Tesoro, Daniele, Vezzosi, Luigi, Gulletta, Maurizio, Clementi, Nicola, Venturelli, Serena, Benardon, Susanna, Ricaboni, Davide, Bernacchia, Dario, Mancon, Alessandro, Rovida, Francesca, Attanasi, Federica, Cereda, Danilo, Gismondo, Maria Rita, Gori, Andrea, Rizzardini, Giuliano, Antinori, Spinello, Baldanti, Fausto, Marzano, Angelo Valerio, Marchetti, Giulia, Castelli, Francesco, Castagna, Antonella, Nozza, Silvia, Mileto, Davide, Bonfanti, Paolo, Biasioli, Lorenzo, Bruno, Raffaele, Vittoria Cossu, Maria, Fusetti, Chiara, Lazzarin, Samuel, Locatelli, Massimo, Morosi, Manuela, Piscaglia, Marco, Pusterla, Luigi, Pozza, Giacomo, Ramoni, Stefano, Rusconi, Stefano, Rizzi, Marco, Rizzo, Alberto, Sabaini, Federico, Salari, Federica, Sampaolo, Michela, Puoti, Massimo, Tirani, Marcello, Rachele Tomasoni, Lina, Moschese, D, Raccagni, A, Giacomelli, A, Piralla, A, Rossotti, R, Raimondi, A, Tesoro, D, Vezzosi, L, Gulletta, M, Clementi, N, Venturelli, S, Benardon, S, Ricaboni, D, Bernacchia, D, Mancon, A, Rovida, F, Attanasi, F, Cereda, D, Gismondo, M, Gori, A, Rizzardini, G, Antinori, S, Baldanti, F, Marzano, A, Marchetti, G, Castelli, F, Castagna, A, Nozza, S, Mileto, D, Bonfanti, P, Biasioli, L, Bruno, R, Vittoria Cossu, M, Fusetti, C, Lazzarin, S, Locatelli, M, Morosi, M, Piscaglia, M, Pusterla, L, Pozza, G, Ramoni, S, Rusconi, S, Rizzi, M, Rizzo, A, Sabaini, F, Salari, F, Sampaolo, M, Puoti, M, Tirani, M, Rachele Tomasoni, L, Moschese, Davide, Raccagni, Angelo Roberto, Giacomelli, Andrea, Piralla, Antonio, Rossotti, Roberto, Raimondi, Alessandro, Tesoro, Daniele, Vezzosi, Luigi, Gulletta, Maurizio, Clementi, Nicola, Venturelli, Serena, Benardon, Susanna, Ricaboni, Davide, Bernacchia, Dario, Mancon, Alessandro, Rovida, Francesca, Attanasi, Federica, Cereda, Danilo, Gismondo, Maria Rita, Gori, Andrea, Rizzardini, Giuliano, Antinori, Spinello, Baldanti, Fausto, Marzano, Angelo Valerio, Marchetti, Giulia, Castelli, Francesco, Castagna, Antonella, Nozza, Silvia, Mileto, Davide, Bonfanti, Paolo, Biasioli, Lorenzo, Bruno, Raffaele, Vittoria Cossu, Maria, Fusetti, Chiara, Lazzarin, Samuel, Locatelli, Massimo, Morosi, Manuela, Piscaglia, Marco, Pusterla, Luigi, Pozza, Giacomo, Ramoni, Stefano, Rusconi, Stefano, Rizzi, Marco, Rizzo, Alberto, Sabaini, Federico, Salari, Federica, Sampaolo, Michela, Puoti, Massimo, Tirani, Marcello, and Rachele Tomasoni, Lina

Published
2024

11. Do we Still Need Eligibility Criteria to Recommend PrEP? Impact of National Prescribing Requirements on Retention in Care and Sexually Transmitted Infections Acquisition

Author

Rossotti, R, Tavelli, A, Calzavara, D, De Bona, A, Muccini, C, Moschese, D, Caruso, E, Soria, A, Bossolasco, S, Lapadula, G, Cernuschi, M, Monforte, A, Rossotti, Roberto, Tavelli, Alessandro, Calzavara, Daniele, De Bona, Anna, Muccini, Camilla, Moschese, Davide, Caruso, Enrico, Soria, Alessandro, Bossolasco, Simona, Lapadula, Giuseppe, Cernuschi, Massimo, Monforte, Antonella d'Arminio, Rossotti, R, Tavelli, A, Calzavara, D, De Bona, A, Muccini, C, Moschese, D, Caruso, E, Soria, A, Bossolasco, S, Lapadula, G, Cernuschi, M, Monforte, A, Rossotti, Roberto, Tavelli, Alessandro, Calzavara, Daniele, De Bona, Anna, Muccini, Camilla, Moschese, Davide, Caruso, Enrico, Soria, Alessandro, Bossolasco, Simona, Lapadula, Giuseppe, Cernuschi, Massimo, and Monforte, Antonella d'Arminio

Abstract

Italian guidelines recommend HIV pre-exposure prophylaxis (PrEP) only upon satisfying strict eligibility criteria. The objective of this study is to evaluate if PrEP candidates attending a community-based service comply with these criteria and whether these prescribing conditions affect retention in care and sexually transmitted infections (STIs) acquisition. A retrospective analysis was performed on PrEP candidates evaluated from January 2019 to June 2022. Data were collected from self-administered questionnaires and clinical files. The population was divided in subjects with 0/1 (0/1 C) and >= 2 (>= 2 C) criteria. Descriptive statistics and non-parametric tests were employed to describe study population. Incidence of PrEP discontinuation and of STIs was estimated per 100 persons-year of follow up (PYFU), and incidence rate ratio (IRR) was calculated. Univariate and multivariable Cox regression analyses were used to evaluate the association strength between PrEP drop out and other variables. The analyses enrolled 659 individuals: 422 individuals were included in 0/1 C, 237 in >= 2 C group, respectively. Inconsistent condom use was the most reported prescribing criteria (399 individuals, 60.6%), followed by a previous STI (186 individuals, 28.2%). 0/1 C exhibited lower STIs incidence. PrEP discontinuation was 29% in 0/1 C and 38% in >= 2 C (p = 0.031). Cox model revealed that inconsistent condom use was the only prescribing criteria associated to PrEP persistence. The majority of PrEP candidate did not comply with prescribing conditions. Eligibility criteria failed to identify individuals with better retention in care. Our results suggest that Italian guidelines should be updated removing barriers to prescription.

Published
2024

12. Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy

Author

Piralla, A, Mileto, D, Rizzo, A, Ferrari, G, Giardina, F, Gaiarsa, S, Petazzoni, G, Bianchi, M, Salari, F, Bracchitta, F, Sammartino, J, Ferrari, A, Gagliardi, G, Mancon, A, Fenizia, C, Biasin, M, Rovida, F, Paolucci, S, Percivalle, E, Lombardi, A, Micheli, V, Nozza, S, Castagna, A, Moschese, D, Antinori, S, Gori, A, Bonfanti, P, Rossotti, R, Monforte, A, Attanasi, F, Tirani, M, Cereda, D, Baldanti, F, Gismondo, M, Cutrera, M, Cuomo, M, De Poli, F, Campanini, G, Pitrolo, A, Iskandar, E, Cassaniti, I, Bruno, R, Rizzardini, G, Puoti, M, Castelli, F, Corsico, L, Giacomelli, A, Pozza, G, Casalini, G, Raccagni, A, Trentacapilli, B, Bertoni, C, Bruzzesi, E, Candela, C, Tesoro, D, Mule, G, Bandera, A, Bianca Mariani, A, Maffeo, M, Vecchio, R, Piccinelli, S, Piralla, Antonio, Mileto, Davide, Rizzo, Alberto, Ferrari, Guglielmo, Giardina, Federica, Gaiarsa, Stefano, Petazzoni, Greta, Bianchi, Micol, Salari, Federica, Bracchitta, Fiorenza, Sammartino, Josè Camilla, Ferrari, Alessandro, Gagliardi, Gloria, Mancon, Alessandro, Fenizia, Claudio, Biasin, Mara, Rovida, Francesca, Paolucci, Stefania, Percivalle, Elena, Lombardi, Alessandra, Micheli, Valeria, Nozza, Silvia, Castagna, Antonella, Moschese, Davide, Antinori, Spinello, Gori, Andrea, Bonfanti, Paolo, Rossotti, Roberto, Monforte, Antonella D'arminio, Attanasi, Federica, Tirani, Marcello, Cereda, Danilo, Baldanti, Fausto, Gismondo, Maria Rita, Cutrera, Miriam, Cuomo, Marianna, De Poli, Federica, Campanini, Giulia, Pitrolo, Antonino Maria Guglielmo, Iskandar, Elizabeth, Cassaniti, Irene, Bruno, Raffaele, Rizzardini, Giuliano, Puoti, Massimo, Castelli, Francesco, Corsico, Laura, Giacomelli, Andrea, Pozza, Giacomo, Casalini, Giacomo, Raccagni, Angelo, Trentacapilli, Bendetta, Bertoni, Costanza, Bruzzesi, Elena, Candela, Caterina, Tesoro, Daniele, Mule, Giovanni, Bandera, Alessandra, Bianca Mariani, Antonio Muscatello, Maffeo, Manuel, Vecchio, Riccardo, Piccinelli, Sara, Piralla, A, Mileto, D, Rizzo, A, Ferrari, G, Giardina, F, Gaiarsa, S, Petazzoni, G, Bianchi, M, Salari, F, Bracchitta, F, Sammartino, J, Ferrari, A, Gagliardi, G, Mancon, A, Fenizia, C, Biasin, M, Rovida, F, Paolucci, S, Percivalle, E, Lombardi, A, Micheli, V, Nozza, S, Castagna, A, Moschese, D, Antinori, S, Gori, A, Bonfanti, P, Rossotti, R, Monforte, A, Attanasi, F, Tirani, M, Cereda, D, Baldanti, F, Gismondo, M, Cutrera, M, Cuomo, M, De Poli, F, Campanini, G, Pitrolo, A, Iskandar, E, Cassaniti, I, Bruno, R, Rizzardini, G, Puoti, M, Castelli, F, Corsico, L, Giacomelli, A, Pozza, G, Casalini, G, Raccagni, A, Trentacapilli, B, Bertoni, C, Bruzzesi, E, Candela, C, Tesoro, D, Mule, G, Bandera, A, Bianca Mariani, A, Maffeo, M, Vecchio, R, Piccinelli, S, Piralla, Antonio, Mileto, Davide, Rizzo, Alberto, Ferrari, Guglielmo, Giardina, Federica, Gaiarsa, Stefano, Petazzoni, Greta, Bianchi, Micol, Salari, Federica, Bracchitta, Fiorenza, Sammartino, Josè Camilla, Ferrari, Alessandro, Gagliardi, Gloria, Mancon, Alessandro, Fenizia, Claudio, Biasin, Mara, Rovida, Francesca, Paolucci, Stefania, Percivalle, Elena, Lombardi, Alessandra, Micheli, Valeria, Nozza, Silvia, Castagna, Antonella, Moschese, Davide, Antinori, Spinello, Gori, Andrea, Bonfanti, Paolo, Rossotti, Roberto, Monforte, Antonella D'arminio, Attanasi, Federica, Tirani, Marcello, Cereda, Danilo, Baldanti, Fausto, Gismondo, Maria Rita, Cutrera, Miriam, Cuomo, Marianna, De Poli, Federica, Campanini, Giulia, Pitrolo, Antonino Maria Guglielmo, Iskandar, Elizabeth, Cassaniti, Irene, Bruno, Raffaele, Rizzardini, Giuliano, Puoti, Massimo, Castelli, Francesco, Corsico, Laura, Giacomelli, Andrea, Pozza, Giacomo, Casalini, Giacomo, Raccagni, Angelo, Trentacapilli, Bendetta, Bertoni, Costanza, Bruzzesi, Elena, Candela, Caterina, Tesoro, Daniele, Mule, Giovanni, Bandera, Alessandra, Bianca Mariani, Antonio Muscatello, Maffeo, Manuel, Vecchio, Riccardo, and Piccinelli, Sara

Abstract

Background: Mpox virus (MPXV) has recently spread outside of sub-Saharan Africa. This large multicentre study was conducted in Lombardy, the most densely populated Italian region accounting for more than 40% of Italian cases. The present study aims to: i) evaluate the presence and the shedding duration of MPXV DNA in different body compartments correlating the MPXV viability with the time to onset of symptoms; ii) provide evidence of MPXV persistence in different body compartment as a source of infection and iii) characterize the MPXV evolution by whole genome sequencing (WGS) during the outbreak occurred in Italy. Material and methods: The study included 353 patients with a laboratory-confirmed diagnosis of MPXV infection screened in several clinical specimens in the period May 24th - September 1st, 2022. Viral isolation was attempted from different biological matrices and complete genome sequencing was performed for 61 MPXV strains. Results: MPXV DNA detection was more frequent in the skin (94.4%) with the longest median time of viral clearance (16 days). The actively-replicating virus in cell culture was obtained for 123/377 (32.6%) samples with a significant higher viral quantity on isolation positive samples (20 vs 31, p < 0.001). The phylogenetic analysis highlighted the high genetic identity of the MPXV strains collected, both globally and within the Lombardy region. Conclusion: Skin lesion is gold standard material and the high viral load and the actively-replicating virus observed in genital sites confirms that sexual contact plays a key role in the viral transmission.

Published
2024

13. Durability of doravirine with dolutegravir dual regimen compared with other dolutegravir‐based dual combinations.

Author

Rossotti, Roberto, D'Amico, Federico, Bana, Nicholas Brian, Nava, Alice, Rezzonico, Leonardo Francesco, Raimondi, Alessandro, Fanti, Diana, Chianura, Leonardo Gerolamo, Moioli, Maria Cristina, Vismara, Chiara, and Puoti, Massimo

Subjects
*COMBINATION drug therapy, *HETEROCYCLIC compounds, *VIRAL load, *TERMINATION of treatment, *HIV infections, *TREATMENT effectiveness, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *MULTIVARIATE analysis, *KAPLAN-Meier estimator, *ANTI-HIV agents, *TREATMENT failure
Abstract

Objective s : The availability of doravirine (DOR) allowed clinicians to prescribe a dolutegravir (DTG)‐based two‐drug regimen (2DR) in individuals not eligible to receive lamivudine (3TC) or rilpivirine (RPV). The aims of this study were to describe the durability of DTG + DOR compared with DTG/3TC and DTG/RPV and the rate of virological failure and target not‐detected maintenance over time. Methods: This retrospective, monocentric analysis included all subjects who started a DTG‐based 2DR from 2018 to 2022 as a simplification. Descriptive statistics and non‐parametric tests to describe and compare the groups were applied. Kaplan–Meier probability curves and Cox regression models for regimens durability were used. Results: The study enrolled 710 individuals: 499 treated with DTG/3TC, 140 with DTG/RPV, and 71 with DTG + DOR. A 2DR with DOR was prescribed to older subjects who had a longer infection, greater exposure to different antiretroviral regimens, a higher proportion of resistance‐associated mutations, and a worse immune‐virologic status. Over a cumulative follow‐up of 68 152 weeks, 42 discontinuations were registered (5.9%). DTG + DOR had a risk of treatment interruption of 7.8% at 48 weeks and 9.8% at 96 weeks, significantly higher than the other 2DRs. In the multivariate Cox model, DTG + DOR and DTG/RPV were significantly associated with discontinuation. The maintenance of target not detected during follow‐up was similar among groups. The rate of virological failure was higher for DTG + DOR through different event definitions. Conclusions: DTG + DOR durability was high over a long follow‐up albeit lower than for other 2DRs. This combination might be an effective option in people with HIV that has proven difficult to treat. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Performance evaluation of a self-administered point of-care test for anal HPV screening in PrEP users: data from a community-based PrEP service.

Author

Biasioli, Lorenzo, Rossotti, Roberto, Tavelli, Alessandro, De Bona, Anna, Tincati, Camilla, Calzavara, Daniele, Vinti, Pietro, Baiguera, Chiara, D’Amico, Federico, Nava, Alice, Repossi, Roberto, Bossolasco, Simona, Muccini, Camilla, Mulè, Giovanni, Tesoro, Daniele, Monforte, Antonella d’Arminio, and Cernuschi, Massimo

Published
2024
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16. Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author

Frigeni, Marco, Besson, Caroline, Visco, Carlo, Fontaine, Helene, Goldaniga, Maria, Visentini, Marcella, Pulsoni, Alessandro, Torres, Harrys A., Peveling-Oberhag, Jan, Rossotti, Roberto, Zaja, Francesco, Rigacci, Luigi, Merli, Michele, Dorival, Céline, Alric, Camille, Piazza, Francesco, Gentile, Massimo, Ferrari, Angela, Pirisi, Mario, Nassi, Luca, Rattotti, Sara, Frustaci, Annamaria, Milella, Michele, Cencini, Emanuele, Defrancesco, Irene, Ferretti, Virginia Valeria, Bruno, Raffaele, Hermine, Olivier, and Arcaini, Luca

Published
2020
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20. Detection of Asymptomatic Mpox Carriers among High-Ri Men Who Have Sex with Men: A Prospective Analysis

Author

Rossotti, Roberto, primary, Calzavara, Daniele, additional, Cernuschi, Massimo, additional, D’Amico, Federico, additional, De Bona, Anna, additional, Repossi, Roberto, additional, Moschese, Davide, additional, Bossolasco, Simona, additional, Tavelli, Alessandro, additional, Muccini, Camilla, additional, Mulé, Giovanni, additional, and d’Arminio Monforte, Antonella, additional

Published
2023
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21. HCV elimination in persons living with HIV (PLWH): the NoCo (No-Coinfection) study of the ICONA network

Author

Monforte, Antonella d’Arminio, primary, Tavelli, Alessandro, additional, Rossotti, Roberto, additional, Gagliardini, Roberta, additional, Saracino, Annalisa, additional, Caputo, Sergio Lo, additional, Sala, Matteo, additional, Quiros-Roldan, Eugenia, additional, Mussini, Cristina, additional, Girardi, Enrico, additional, Antinori, Andrea, additional, and Puoti, Massimo, additional

Published
2023
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23. Interferon-free antiviral treatment in B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author

Arcaini, Luca, Besson, Caroline, Frigeni, Marco, Fontaine, Hélène, Goldaniga, Maria, Casato, Milvia, Visentini, Marcella, Torres, Harrys A., Loustaud-Ratti, Veronique, Peveling-Oberhag, Jan, Fabris, Paolo, Rossotti, Roberto, Zaja, Francesco, Rigacci, Luigi, Rattotti, Sara, Bruno, Raffaele, Merli, Michele, Dorival, Céline, Alric, Laurent, Jaccard, Arnaud, Pol, Stanislas, Carrat, Fabrice, Ferretti, Virginia Valeria, Visco, Carlo, and Hermine, Olivier

Published
2016
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24. Is HCV elimination among persons living with HIV feasible? Data from the NoCo study in the setting of the ICONA cohort.

Author

d'Arminio Monforte, Antonella, Tavelli, Alessandro, Rossotti, Roberto, Gagliardini, Roberta, Saracino, Annalisa, Lo Caputo, Sergio, Sala, Matteo, Quiros‐Roldan, Eugenia, Mussini, Cristina, Girardi, Enrico, Cozzi‐Lepri, Alessandro, Antinori, Andrea, Puoti, Massimo, Costantini, A, Saracino, A, Milano, E, Maggiolo, F, Suardi, C, Quiros Roldan, E, and Minardi, C

Subjects
POISSON regression, LOGISTIC regression analysis, CD4 lymphocyte count, HIV, REINFECTION
Abstract

Background and Aims: Whether the HCV test‐and‐treat strategy impacted on the rate of new HCV infections among PLWH in Italy is unknown. Methods: Prospective study of PLWH in the ICONA network. At baseline, PLWH were tested for HCV‐Ab; HCV‐RNA (if HCV‐Ab positive) and, if positive, treated with DAA. SVR12 indicated eradication. Seroconversions and re‐infections were evaluated yearly in HCV‐Ab neg and HCV‐RNA neg at first screening. We estimated the following: HCV seroconversions, incidence of HCV reinfections, and access to DAA and SVR12 rates tighter with factors associated with each outcome. Data were analysed by Cox regression, Poisson regression and logistic regression models. Results: Sixteen thousand seven hundred and forty‐three PLWH were included; 27.3% HCV‐Ab positive; of these, 39.3% HCV‐RNA positive. HCV seroconversion incidence:.48/100 PYFU (95% CI:.36–.65); re‐infections incidence: 1.40/100 PYFU (95% CI:.91–2.04). The risk factor for HCV re‐infection was young age: aIRR 1.85, 95% CI: 1.17–2.95) per 10 years younger. 86.4% of HCV viremic in follow‐up started DAA. PWID vs. heterosexuals (aHR.75, 95% CI.62–.90), HIV‐RNA >50 copies/mL (aHR.70, 95% CI.56–.87), HCV genotype other than G1, G2, G3, G4 or with multiple/missing HCV genotype and post‐COVID‐19 calendar periods were associated with lower DAA access. 922/965 (95.5%) PLWH achieved SVR12. We estimated 72% reduction of chance to achieve SVR12 in PLWH with a CD4 count <200/mm3 (vs. CD4 ≥200/mm3 aOR.18, 95% CI:.07–.46). 95.5% of DAA‐treated individuals eradicated HCV, but they represent only 53.2% of HCV viremic PLWH and 66.4% of those in follow‐up. HCV‐RNA positivity by year decreased from 41.7% in 2017 to 11.7% in 2022. Conclusions: The screening‐and‐treat campaign implemented in Italy, even if only partially effective, resulted in a dramatic drop in HCV circulation in our cohort. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Impact of treatment with direct‐acting antivirals on inflammatory markers and autoantibodies in HIV/HCV co‐infected individuals

Author

Rossotti, Roberto, primary, Merli, Marco, additional, Baiguera, Chiara, additional, Bana, Nicholas Brian, additional, Rezzonico, Leonardo Francesco, additional, D'Amico, Federico, additional, Raimondi, Alessandro, additional, Moioli, Maria Cristina, additional, Chianura, Leonardo Gerolamo, additional, and Puoti, Massimo, additional

Published
2023
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26. Similar survival but higher and delayed hepatocellular carcinoma recurrence in HIV-positive compared to negative cirrhotics undergoing liver transplantation

Author

Rossotti, Roberto, primary, Merli, Marco, additional, Mazzarelli, Chiara, additional, De Carlis, Riccardo Maria, additional, Travi, Giovanna, additional, Vecchi, Marta, additional, Viganò, Raffaella, additional, Lauterio, Andrea, additional, Raimondi, Alessandro, additional, Belli, Luca Saverio, additional, De Carlis, Luciano Gregorio, additional, and Puoti, Massimo, additional

Published
2023
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32. HIV‐NAAT use for early detection of HIV infection among high‐risk men who have sex with men in Italy

Author

Raccagni, Angelo Roberto, primary, Bruzzesi, Elena, additional, Calzavara, Daniele, additional, Vinti, Pietro, additional, Cernuschi, Massimo, additional, Bossolasco, Simona, additional, De Bona, Anna, additional, Rossotti, Roberto, additional, D'Arminio Monforte, Antonella, additional, Castagna, Antonella, additional, and Nozza, Silvia, additional

Published
2022
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37. Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy

Author

Bandera, Alessandra, Blasi, Francesco, Campisi, Daniela, Ferrarese, Maurizio, Gramegna, Andrea, Lombardi, Alessandra, Mancon, Alessandro, Mantero, Marco, Muscatello, Antonio, Passerini, Matteo, Piscaglia, Marco, Saporiti, Matteo, Schiuma, Marco, Torre, Alessandro, Aliberti, Stefano, Castellotti, Paola Francesca, Cirillo, Daniela Maria, Grisolia, Antonella, Mangioni, Davide, Marchetti, Giulia, Rossotti, Roberto, Santus, Pierachille, Besozzi, Giorgio, Villa, Simone, and Codecasa, Luigi Ruffo

Published
2020
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41. Impact of immunosuppressive therapy on the severity of COVID-19 in solid organ transplant recipients

Author

Merli, Marco, primary, Pasulo, Luisa, additional, Perricone, Giovanni, additional, Travi, Giovanna, additional, Rossotti, Roberto, additional, Colombo, Valeriana Giuseppina, additional, De Carlis, Riccardo, additional, Chiappetta, Stefania, additional, Moioli, Maria Cristina, additional, Minetti, Enrico, additional, Frigerio, Maria, additional, De Carlis, Luciano Gregorio, additional, Belli, Luca, additional, Fagiuoli, Stefano, additional, and Puoti, Massimo, additional

Published
2021
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43. Clinical outcome in solid organ transplant recipients with COVID-19: A single-center experience

Author

Travi, G, Rossotti, R, Merli, M, Sacco, A, Perricone, G, Lauterio, A, Colombo, V, De Carlis, L, Frigerio, M, Minetti, E, Belli, L, Puoti, M, Travi, Giovanna, Rossotti, Roberto, Merli, Marco, Sacco, Alice, Perricone, Giovanni, Lauterio, Andrea, Colombo, Valeriana Giuseppina, De Carlis, Luciano, Frigerio, Maria, Minetti, Enrico, Belli, Luca, Puoti, Massimo, Travi, G, Rossotti, R, Merli, M, Sacco, A, Perricone, G, Lauterio, A, Colombo, V, De Carlis, L, Frigerio, M, Minetti, E, Belli, L, Puoti, M, Travi, Giovanna, Rossotti, Roberto, Merli, Marco, Sacco, Alice, Perricone, Giovanni, Lauterio, Andrea, Colombo, Valeriana Giuseppina, De Carlis, Luciano, Frigerio, Maria, Minetti, Enrico, Belli, Luca, and Puoti, Massimo

Published
2020

44. Development and validation of a prediction model for tocilizumab failure in hospitalized patients with SARS-CoV-2 infection

Author

Mussini, Cristina, primary, Cozzi-Lepri, Alessandro, additional, Menozzi, Marianna, additional, Meschiari, Marianna, additional, Franceschini, Erica, additional, Milic, Jovana, additional, Brugioni, Lucio, additional, Pietrangelo, Antonello, additional, Girardis, Massimo, additional, Cossarizza, Andrea, additional, Tonelli, Roberto, additional, Clini, Enrico, additional, Massari, Marco, additional, Bartoletti, Michele, additional, Ferrari, Anna, additional, Cattelan, Anna Maria, additional, Zuccalà, Paola, additional, Lichtner, Miriam, additional, Rossotti, Roberto, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, Puoti, Massimo, additional, Antinori, Andrea, additional, Viale, Pierluigi, additional, and Guaraldi, Giovanni, additional

Published
2021
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46. Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy

Author

Torre, Alessandro, primary, Aliberti, Stefano, additional, Castellotti, Paola Francesca, additional, Cirillo, Daniela Maria, additional, Grisolia, Antonella, additional, Mangioni, Davide, additional, Marchetti, Giulia, additional, Rossotti, Roberto, additional, Santus, Pierachille, additional, Besozzi, Giorgio, additional, Villa, Simone, additional, Codecasa, Luigi Ruffo, additional, Bandera, Alessandra, additional, Blasi, Francesco, additional, Campisi, Daniela, additional, Ferrarese, Maurizio, additional, Gramegna, Andrea, additional, Lombardi, Alessandra, additional, Mancon, Alessandro, additional, Mantero, Marco, additional, Muscatello, Antonio, additional, Passerini, Matteo, additional, Piscaglia, Marco, additional, Saporiti, Matteo, additional, and Schiuma, Marco, additional

Published
2020
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