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426 results on '"Roumenina, Lubka T."'

1. Complement Terminal Pathway Activation and Intrarenal Immune Response in C3 Glomerulopathy

Author

Meuleman, Marie-Sophie, Petitprez, Florent, Pickering, Matthew C., Le Quintrec, Moglie, Artero, Mikel Rezola, Duval, Anna, Rabant, Marion, Gilmore, Alyssa, Boyer, Olivia, Hogan, Julien, Servais, Aude, Provot, François, Gnemmi, Vivianne, Eloudzeri, Maeva, Grunenwald, Anne, Buob, David, Boffa, Jean-Jacques, Moktefi, Anissa, Audard, Vincent, Goujon, Jean-Michel, Bridoux, Frank, Thervet, Eric, Karras, Alexandre, Roumenina, Lubka T., Frémeaux Bacchi, Véronique, Duong Van Huyen, Jean-Paul, and Chauvet, Sophie

Published
2024
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5. Hemopexin and albumin inhibit heme-induced macrophage activation while also enabling heme-LPS synergistic promotion of TNF production

Author

Silva, Rafael Cardoso Maciel Costa, Tan, Luis Batista, Gama, Andreza Moreira dos Santos, De Cicco, Nuccia Nicole Theodoro, Merle, Nicolas S., Roumenina, Lubka T., Zhang, Yi, Henderson, Gregory C., Gonçalves, André N.A., Atella, Georgia C., Marques, João Trindade, Travassos, Leonardo Holanda, Paiva, Claudia N., Manoury, Bénédicte, and Bozza, Marcelo Torres

Published
2023
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8. Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression

Author

Revel, Margot, primary, Rezola Artero, Mikel, additional, Hamidi, Houcine, additional, Grunenwald, Anne, additional, Blasco, Loris, additional, Vano, Yann A., additional, Marie Oudard, Stephane, additional, Sanchez-Salas, Rafael, additional, Macek, Petr, additional, Rodriguez Sanchez, Lara, additional, Cathelineau, Xavier, additional, Vedié, Benoit, additional, Sautes-Fridman, Catherine, additional, Herman Fridman, Wolf, additional, Roumenina, Lubka T., additional, and Dragon-Durey, Marie-Agnes, additional

Published
2024
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13. Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

Author

Boudhabhay, Idris, Poillerat, Victoria, Grunenwald, Anne, Torset, Carine, Leon, Juliette, Daugan, Marie V., Lucibello, Francesca, El Karoui, Khalil, Ydee, Amandine, Chauvet, Sophie, Girardie, Patrick, Sacks, Steven, Farrar, Conrad A., Garred, Peter, Berthaud, Romain, Le Quintrec, Moglie, Rabant, Marion, de Lonlay, Pascale, Rambaud, Caroline, Gnemmi, Viviane, Fremeaux-Bacchi, Veronique, Frimat, Marie, and Roumenina, Lubka T.

Published
2021
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14. Insights into the molecular basis and mechanism of heme‐triggered TLR4 signalling: The role of heme‐binding motifs in TLR4 and MD2

Author

Hopp, Marie‐T., primary, Holze, Janine, additional, Lauber, Felicitas, additional, Holtkamp, Laura, additional, Rathod, Dhruv C., additional, Miteva, Maria A., additional, Prestes, Elisa B., additional, Geyer, Matthias, additional, Manoury, Bénédicte, additional, Merle, Nicolas S., additional, Roumenina, Lubka T., additional, Bozza, Marcelo T., additional, Weindl, Günther, additional, and Imhof, Diana, additional

Published
2023
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21. Insights into the molecular basis and mechanism of heme‐triggered TLR4 signalling: The role of heme‐binding motifs in TLR4 and MD2.

Author

Hopp, Marie‐T., Holze, Janine, Lauber, Felicitas, Holtkamp, Laura, Rathod, Dhruv C., Miteva, Maria A., Prestes, Elisa B., Geyer, Matthias, Manoury, Bénédicte, Merle, Nicolas S., Roumenina, Lubka T., Bozza, Marcelo T., Weindl, Günther, and Imhof, Diana

Subjects
TOLL-like receptors, SICKLE cell anemia, BINDING sites, ECULIZUMAB, BLOOD coagulation, HEME
Abstract

Haemolytic disorders, such as sickle cell disease, are accompanied by the release of high amounts of labile heme into the intravascular compartment resulting in the induction of proinflammatory and prothrombotic complications in affected patients. In addition to the relevance of heme‐regulated proteins from the complement and blood coagulation systems, activation of the TLR4 signalling pathway by heme was ascribed a crucial role in the progression of these pathological processes. Heme binding to the TLR4‐MD2 complex has been proposed recently, however, essential mechanistic information of the processes at the molecular level, such as heme‐binding kinetics, the heme‐binding capacity and the respective heme‐binding sites (HBMs) is still missing. We report the interaction of TLR4, MD2 and the TLR4‐MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic and physiologically relevant approaches. Heme binding occurs transiently through interaction with up to four HBMs in TLR4, two HBMs in MD2 and at least four HBMs in their complex. Functional studies highlight that mutations of individual HBMs in TLR4 preserve full receptor activation by heme, suggesting that heme interacts with TLR4 through different binding sites independently of MD2. Furthermore, we confirm and extend the major role of TLR4 for heme‐mediated cytokine responses in human immune cells. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H

Author

Madden, Iona, Roumenina, Lubka T., Langlois-Meurinne, Hélène, Guichoux, Julie, Llanas, Brigitte, Frémeaux-Bacchi, Véronique, and Harambat, Jérôme

Subjects
Hemolytic-uremic syndrome -- Risk factors -- Diagnosis -- Care and treatment -- Case studies, Bordetella pertussis -- Physiological aspects, Health
Abstract

Background Hemolytic uremic syndrome (HUS) has been associated with a number of infectious agents. We report here the case of an infant with severe Bordetella pertussis infection who developed HUS. Case diagnosis/treatment A 2-month-old preterm male was admitted for severe Bordetella pertussis infection. Symptoms leading to a diagnosis of hemolytic uremic syndrome (HUS) rapidly appeared: hemolytic anemia, thrombocytopenia, and acute kidney injury. He was treated with 25 days of peritoneal dialysis and received complement-targeting therapy with eculizumab (five injections over 2 months), in addition to blood transfusions, antibiotics, and respiratory support. The outcome was favorable. The genetic workup found a complement factor H gene variant which has been associated with atypical HUS. This variant was located in the C3b-binding site and functional tests revealed that it perturbed the regulatory activity of factor H. Conclusion This case suggests that pertussis is a strong trigger of HUS and that complement investigations are necessary to guide treatment and understand the pathophysiology., Author(s): Iona Madden [sup.1] [sup.2] , Lubka T. Roumenina [sup.3] [sup.4] , Hélène Langlois-Meurinne [sup.2] , Julie Guichoux [sup.5] , Brigitte Llanas [sup.1] , Véronique Frémeaux-Bacchi [sup.3] [sup.6] , Jérôme [...]

Published
2019
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23. Endothelium structure and function in kidney health and disease

Author

Jourde-Chiche, Noemie, Fakhouri, Fadi, Dou, Laetitia, Bellien, Jeremy, Burtey, Stéphane, Frimat, Marie, Jarrot, Pierre-André, Kaplanski, Gilles, Le Quintrec, Moglie, Pernin, Vincent, Rigothier, Claire, Sallée, Marion, Fremeaux-Bacchi, Veronique, Guerrot, Dominique, and Roumenina, Lubka T.

Published
2019
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26. Supplementary Tables from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade

Author

Daugan, Marie V., primary, Revel, Margot, primary, Thouenon, Romane, primary, Dragon-Durey, Marie-Agnès, primary, Robe-Rybkine, Tania, primary, Torset, Carine, primary, Merle, Nicolas S., primary, Noé, Rémi, primary, Verkarre, Virginie, primary, Oudard, Stephane Marie, primary, Mejean, Arnaud, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Pickering, Mathew C., primary, Cremer, Isabelle, primary, Mansuet-Lupo, Audrey, primary, Alifano, Marco, primary, Sautès-Fridman, Catherine, primary, Damotte, Diane, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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27. Supplementary Data from Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment

Author

Garmendia, Irati, primary, Varthaman, Aditi, primary, Marmier, Solenne, primary, Angrini, Mahmud, primary, Matchoua, Ingrid, primary, Darbois-Delahousse, Aurelie, primary, Josseaume, Nathalie, primary, Foy, Pierre-Emmanuel, primary, Roumenina, Lubka T., primary, Naouar, Naïra, primary, Meylan, Maxime, primary, Sibéril, Sophie, primary, Russick, Jules, primary, Joubert, Pierre-Emmanuel, primary, Leroy, Karen, primary, Damotte, Diane, primary, Mansuet-Lupo, Audrey, primary, Wislez, Marie, primary, Alifano, Marco, primary, Menger, Laurie, primary, Garcia-Verdugo, Ignacio, primary, Sallenave, Jean-Michel, primary, Lantz, Olivier, primary, Petitprez, Florent, primary, and Cremer, Isabelle, primary

Published
2023
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28. Supplementary Figures from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade

Author

Daugan, Marie V., primary, Revel, Margot, primary, Thouenon, Romane, primary, Dragon-Durey, Marie-Agnès, primary, Robe-Rybkine, Tania, primary, Torset, Carine, primary, Merle, Nicolas S., primary, Noé, Rémi, primary, Verkarre, Virginie, primary, Oudard, Stephane Marie, primary, Mejean, Arnaud, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Pickering, Mathew C., primary, Cremer, Isabelle, primary, Mansuet-Lupo, Audrey, primary, Alifano, Marco, primary, Sautès-Fridman, Catherine, primary, Damotte, Diane, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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29. Data from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade

Author

Daugan, Marie V., primary, Revel, Margot, primary, Thouenon, Romane, primary, Dragon-Durey, Marie-Agnès, primary, Robe-Rybkine, Tania, primary, Torset, Carine, primary, Merle, Nicolas S., primary, Noé, Rémi, primary, Verkarre, Virginie, primary, Oudard, Stephane Marie, primary, Mejean, Arnaud, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Pickering, Mathew C., primary, Cremer, Isabelle, primary, Mansuet-Lupo, Audrey, primary, Alifano, Marco, primary, Sautès-Fridman, Catherine, primary, Damotte, Diane, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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30. Data from Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s

Author

Daugan, Marie V., primary, Revel, Margot, primary, Russick, Jules, primary, Dragon-Durey, Marie-Agnès, primary, Gaboriaud, Christine, primary, Robe-Rybkine, Tania, primary, Poillerat, Victoria, primary, Grunenwald, Anne, primary, Lacroix, Guillaume, primary, Bougouin, Antoine, primary, Meylan, Maxime, primary, Verkarre, Virginie, primary, Oudard, Stephane M., primary, Mejean, Arnaud, primary, Vano, Yann A., primary, Perkins, Geraldine, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Damotte, Diane, primary, Fremeaux-Bacchi, Veronique, primary, Cremer, Isabelle, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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31. Data from Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment

Author

Garmendia, Irati, primary, Varthaman, Aditi, primary, Marmier, Solenne, primary, Angrini, Mahmud, primary, Matchoua, Ingrid, primary, Darbois-Delahousse, Aurelie, primary, Josseaume, Nathalie, primary, Foy, Pierre-Emmanuel, primary, Roumenina, Lubka T., primary, Naouar, Naïra, primary, Meylan, Maxime, primary, Sibéril, Sophie, primary, Russick, Jules, primary, Joubert, Pierre-Emmanuel, primary, Leroy, Karen, primary, Damotte, Diane, primary, Mansuet-Lupo, Audrey, primary, Wislez, Marie, primary, Alifano, Marco, primary, Menger, Laurie, primary, Garcia-Verdugo, Ignacio, primary, Sallenave, Jean-Michel, primary, Lantz, Olivier, primary, Petitprez, Florent, primary, and Cremer, Isabelle, primary

Published
2023
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32. Supplementary Tables from Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s

Author

Daugan, Marie V., primary, Revel, Margot, primary, Russick, Jules, primary, Dragon-Durey, Marie-Agnès, primary, Gaboriaud, Christine, primary, Robe-Rybkine, Tania, primary, Poillerat, Victoria, primary, Grunenwald, Anne, primary, Lacroix, Guillaume, primary, Bougouin, Antoine, primary, Meylan, Maxime, primary, Verkarre, Virginie, primary, Oudard, Stephane M., primary, Mejean, Arnaud, primary, Vano, Yann A., primary, Perkins, Geraldine, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Damotte, Diane, primary, Fremeaux-Bacchi, Veronique, primary, Cremer, Isabelle, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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33. Supplementary Figures from Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s

Author

Daugan, Marie V., primary, Revel, Margot, primary, Russick, Jules, primary, Dragon-Durey, Marie-Agnès, primary, Gaboriaud, Christine, primary, Robe-Rybkine, Tania, primary, Poillerat, Victoria, primary, Grunenwald, Anne, primary, Lacroix, Guillaume, primary, Bougouin, Antoine, primary, Meylan, Maxime, primary, Verkarre, Virginie, primary, Oudard, Stephane M., primary, Mejean, Arnaud, primary, Vano, Yann A., primary, Perkins, Geraldine, primary, Validire, Pierre, primary, Cathelineau, Xavier, primary, Sanchez-Salas, Rafael, primary, Damotte, Diane, primary, Fremeaux-Bacchi, Veronique, primary, Cremer, Isabelle, primary, Sautès-Fridman, Catherine, primary, Fridman, Wolf H., primary, and Roumenina, Lubka T., primary

Published
2023
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34. Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment

Author

Garmendia, Irati, primary, Varthaman, Aditi, additional, Marmier, Solenne, additional, Angrini, Mahmud, additional, Matchoua, Ingrid, additional, Darbois-Delahousse, Aurelie, additional, Josseaume, Nathalie, additional, Foy, Pierre-Emmanuel, additional, Roumenina, Lubka T., additional, Naouar, Naïra, additional, Meylan, Maxime, additional, Sibéril, Sophie, additional, Russick, Jules, additional, Joubert, Pierre-Emmanuel, additional, Leroy, Karen, additional, Damotte, Diane, additional, Mansuet-Lupo, Audrey, additional, Wislez, Marie, additional, Alifano, Marco, additional, Menger, Laurie, additional, Garcia-Verdugo, Ignacio, additional, Sallenave, Jean-Michel, additional, Lantz, Olivier, additional, Petitprez, Florent, additional, and Cremer, Isabelle, additional

Published
2023
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43. IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice

Author

Todorova, Biliana, primary, Godon, Ophélie, additional, Conde, Eva, additional, Gillis, Caitlin M., additional, Iannascoli, Bruno, additional, Richard-Le Goff, Odile, additional, Fiole, Daniel, additional, Roumenina, Lubka T., additional, Leusen, Jeanette H. W., additional, Murphy, Andrew J., additional, Macdonald, Lynn E., additional, Reber, Laurent L., additional, Jönsson, Friederike, additional, and Bruhns, Pierre, additional

Published
2022
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45. Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation

Author

Gerogianni, Alexandra, primary, Dimitrov, Jordan D., additional, Zarantonello, Alessandra, additional, Poillerat, Victoria, additional, Chonat, Satheesh, additional, Sandholm, Kerstin, additional, McAdam, Karin E., additional, Ekdahl, Kristina N., additional, Mollnes, Tom E., additional, Mohlin, Camilla, additional, Roumenina, Lubka T., additional, and Nilsson, Per H., additional

Published
2022
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48. C3‐dependent effector functions of complement.

Author

Zarantonello, Alessandra, Revel, Margot, Grunenwald, Anne, and Roumenina, Lubka T.

Subjects
IMMUNE response, COMPLEMENT receptors, COMPLEMENT activation, BINDING sites, COMPLEMENT (Immunology)
Abstract

Summary: C3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites. To highlight the important role that C3 plays in human biological processes, we will give an overview of the diseases linked to C3 deficiency and to uncontrolled C3 activation. Next, we will present a structural description of C3 activation and of the C3 fragments generated by complement regulation. We will proceed by describing the C3a interaction with the anaphylatoxin receptor, followed by the interactions of opsonins (C3b, iC3b, and C3dg/C3d) with complement receptors, divided into two groups: receptors bearing complement regulatory functions and the effector receptors without complement regulatory activity. We outline the molecular architecture of the receptors, their binding sites on the C3 activation fragments, the cells expressing them, the diversity of their functions, and recent advances. With this review, we aim to give an up‐to‐date analysis of the processes triggered by C3 activation fragments on different cell types in health and disease contexts. [ABSTRACT FROM AUTHOR]

Published
2023
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