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192 results on '"Roussel, Arnaud"'

2. A New Era: Intelligent Tutoring Systems Will Transform Online Learning for Millions

Author

St-Hilaire, Francois, Vu, Dung Do, Frau, Antoine, Burns, Nathan, Faraji, Farid, Potochny, Joseph, Robert, Stephane, Roussel, Arnaud, Zheng, Selene, Glazier, Taylor, Romano, Junfel Vincent, Belfer, Robert, Shayan, Muhammad, Smofsky, Ariella, Delarosbil, Tommy, Ahn, Seulmin, Eden-Walker, Simon, Sony, Kritika, Ching, Ansona Onyi, Elkins, Sabina, Stepanyan, Anush, Matajova, Adela, Chen, Victor, Sahraei, Hossein, Larson, Robert, Markova, Nadia, Barkett, Andrew, Charlin, Laurent, Bengio, Yoshua, Serban, Iulian Vlad, and Kochmar, Ekaterina

Subjects
Computer Science - Computers and Society, Computer Science - Artificial Intelligence, Computer Science - Human-Computer Interaction, Computer Science - Machine Learning, I.2.0, K.3.1, K.4.0
Abstract

Despite artificial intelligence (AI) having transformed major aspects of our society, less than a fraction of its potential has been explored, let alone deployed, for education. AI-powered learning can provide millions of learners with a highly personalized, active and practical learning experience, which is key to successful learning. This is especially relevant in the context of online learning platforms. In this paper, we present the results of a comparative head-to-head study on learning outcomes for two popular online learning platforms (n=199 participants): A MOOC platform following a traditional model delivering content using lecture videos and multiple-choice quizzes, and the Korbit learning platform providing a highly personalized, active and practical learning experience. We observe a huge and statistically significant increase in the learning outcomes, with students on the Korbit platform providing full feedback resulting in higher course completion rates and achieving learning gains 2 to 2.5 times higher than both students on the MOOC platform and students in a control group who don't receive personalized feedback on the Korbit platform. The results demonstrate the tremendous impact that can be achieved with a personalized, active learning AI-powered system. Making this technology and learning experience available to millions of learners around the world will represent a significant leap forward towards the democratization of education., Comment: 9 pages, 6 figures

Published
2022

7. Outcome of Lung Transplantation Using Grafts From Donors Over 65 Years of Age

Author

Boudinet, Sandrine, Jean-Baptiste, Sylvain, Longrois, Dan, Lortat-Jacob, Brice, Montravers, Philippe, Tran Dinh, Alexy, Hammouda, Malika, Lefèvre, Lucie, Savary, Alice, Abadie, Agnès, Brouk, Zohra, Renard, Régis, Girault, Antoine, Avramenko-Bouvier, Alla, Roussel, Arnaud, Cerceau, Pierre, Pellenc, Quentin, Bunel, Vincent, Godet, Cendrine, Jebrak, Gilles, Messika, Jonathan, Mal, Hervé, Castier, Yves, and Mordant, Pierre

Published
2021
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14. Survival outcomes following urgent lung transplantation in France and the USA.

Author

Roussel, Arnaud, Sage, Edouard, Falcoz, Pierre-Emmanuel, Thomas, Pascal Alexandre, Castier, Yves, Fadel, Elie, Le Pimpec-Barthes, Françoise, Tronc, François, Jougon, Jacques, Lacoste, Philippe, Claustre, Johanna, Brouchet, Laurent, Dorent, Richard, Cantu, Edward, Harhay, Michael, Porcher, Raphaël, and Mordant, Pierre

Subjects
MEDICAL care, SURVIVAL rate, LUNG transplantation, ARTIFICIAL blood circulation, PROPORTIONAL hazards models, ARTIFICIAL respiration, BRONCHIECTASIS, BLOOD group incompatibility
Published
2024
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16. Iloprost Use in Patients with Persistent Intestinal Ischemia Unsuitable for Revascularization

Author

Corcos, Olivier, Bouhnik, Yoram, Nuzzo, Alexandre, Stefanescu, Carmen, Treton, Xavier, Joly, Francisca, Billiauws, Lore, Panis, Yves, Maggiori, Leon, Prost à la Denise, Justine, Tribillon, Ecoline, Laforêt, Anaïs, Lakkis, Zaher, Sibert, Annie, Zappa, Magaly, Garcia-Alba, Carmela, Abdel-Rehim, Mohamed, Vilgrain, Valérie, Bertin, Caroline, Kerbaol, Anne, Allaham, Wassim, Lagadec, Matthieu, Benzimra, Julie, Ronot, Maxime, Paugam, Catherine, Weiss, Emmanuel, Abback, Paer-Selim, Delefosse, Didier, Enriquez, Isabelle, Janny, Sylvie, Toussaint, Amélie, Iserentant, Jules, Bout, Helene, Pease, Sebastian, Ear, Linda Koy, Castier, Yves, Pellenc, Quentin, Roussel, Arnaud, Cerceau, Pierre, Mordant, Pierre, Deblic, Romain, Boulitrop, Celia, Curac, Sonja, Cachier, Agnès, Plessier, Aurelie, Rautou, Pierre-Emmanuel, Valla, Dominique, Soubrane, Olivier, Sauvanet, Alain, Dokmak, Safi, Dondero, Federica, Sepulveda, Ailton, Farges, Olivier, Aussilhou, Beatrice, Palazzo, Maxime, Cazals-Hatem, Dominique, De Raucourt, Emmanuelle, Boudaoud, Larbi, Peoc'h, Katell, Puy, Herve, Pons-Kerjean, Nathalie, Stocco, Jeanick, Bataille, Julie, Bouton, Valérie, Diop, Aziz, Gault, Nathalie, Montravers, Philippe, Augustin, Pascal, Jacob, Brice Lortat, Soudan, Damien, and Maggiori, Léon

Published
2017
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17. Prolonged mechanical ventilation after lung transplantation: risks factors and consequences on recipient outcome

Author

Atchade, Enora, primary, Boughaba, Aimane, additional, Dinh, Alexy Tran, additional, Jean-Baptiste, Sylvain, additional, Tanaka, Sébastien, additional, Copelovici, Léa, additional, Lortat-Jacob, Brice, additional, Roussel, Arnaud, additional, Castier, Yves, additional, Messika, Jonathan, additional, Mal, Hervé, additional, Tymowski, Christian de, additional, and Montravers, Philippe, additional

Published
2023
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19. First use of imlifidase desensitization in a highly sensitized lung transplant candidate: a case report

Author

Roux, Antoine, primary, Bunel, Vincent, additional, Belousova, Natalia, additional, Messika, Jonathan, additional, Tanaka, Sebastien, additional, Salpin, Mathilde, additional, Roussel, Arnaud, additional, Beaumont-Azuar, Laurence, additional, Picard, Clement, additional, Brugiere, Olivier, additional, Devaquet, Jerome, additional, Sage, Edouard, additional, Le guen, Morgan, additional, Taupin, Jean-Luc, additional, Devriese, Magali, additional, Glorion, Mathieu, additional, and Parquin, Francois, additional

Published
2023
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21. Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation

Author

Hin, Angela, Kannengiesser, Caroline, Roussel, Arnaud, Renaud-Picard, Benjamin, Roux, Antoine, Reynaud-Gaubert, Martine, Claustre, Johanna, Tissot, Adrien, Guillemain, Romain, Mornex, Jean-François, Mussot, Sacha, Dromer, Claire, Dahan, Marcel, Brugière, Olivier, Mercier, Olaf, Borie, Raphaël, Pretolani, Marina, Castier, Yves, and Mordant, Pierre

Published
2018
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22. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort

Author

Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, and Borie, Raphaël

Published
2022
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23. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort.

Author

UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network

Abstract

Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.

Published
2022

25. Artificial intelligence for diagnosis and Gleason grading of prostate cancer : the PANDA challenge

Author

Bulten, Wouter, Kartasalo, Kimmo, Chen, Po-Hsuan Cameron, Ström, Peter, Pinckaers, Hans, Nagpal, Kunal, Cai, Yuannan, Steiner, David F., van Boven, Hester, Vink, Robert, Hulsbergen-van de Kaa, Christina, van der Laak, Jeroen, Amin, Mahul B., Evans, Andrew J., van der Kwast, Theodorus, Allan, Robert, Humphrey, Peter A., Grönberg, Henrik, Samaratunga, Hemamali, Delahunt, Brett, Tsuzuki, Toyonori, Häkkinen, Tomi, Egevad, Lars, Demkin, Maggie, Dane, Sohier, Tan, Fraser, Valkonen, Masi, Corrado, Greg S., Peng, Lily, Mermel, Craig H., Ruusuvuori, Pekka, Litjens, Geert, Eklund, Martin, Brilhante, Américo, Çakır, Aslı, Farré, Xavier, Geronatsiou, Katerina, Molinié, Vincent, Pereira, Guilherme, Roy, Paromita, Saile, Günter, Salles, Paulo G. O., Schaafsma, Ewout, Tschui, Joëlle, Billoch-Lima, Jorge, Pereira, Emíio M., Zhou, Ming, He, Shujun, Song, Sejun, Sun, Qing, Yoshihara, Hiroshi, Yamaguchi, Taiki, Ono, Kosaku, Shen, Tao, Ji, Jianyi, Roussel, Arnaud, Zhou, Kairong, Chai, Tianrui, Weng, Nina, Grechka, Dmitry, Tampere University, and BioMediTech

Subjects
Male, Urologic Diseases, Biopsy, Immunology, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, PANDA challenge, Artificial Intelligence, Humans, Gleason Grading, Cancer, Cancer och onkologi, 318 Medical biotechnology, Prostate Cancer, Prostatic Neoplasms, Reproducibility of Results, General Medicine, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Research Highlights, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Cancer and Oncology, PANDA challenge consortium, Neoplasm Grading, Algorithms
Abstract

Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital pathology. Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions have been shown to be accelerators for medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this in mind, we organized the PANDA challenge-the largest histopathology competition to date, joined by 1,290 developers-to catalyze development of reproducible AI algorithms for Gleason grading using 10,616 digitized prostate biopsies. We validated that a diverse set of submitted algorithms reached pathologist-level performance on independent cross-continental cohorts, fully blinded to the algorithm developers. On United States and European external validation sets, the algorithms achieved agreements of 0.862 (quadratically weighted kappa, 95% confidence interval (CI), 0.840-0.884) and 0.868 (95% CI, 0.835-0.900) with expert uropathologists. Successful generalization across different patient populations, laboratories and reference standards, achieved by a variety of algorithmic approaches, warrants evaluating AI-based Gleason grading in prospective clinical trials. Funding Agencies|Dutch Cancer SocietyKWF Kankerbestrijding [KUN 2015-7970]; Netherlands Organization for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [016.186.152]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [201901466, 2020-00692]; Swedish Cancer Society (CAN)Swedish Cancer Society [2018/741]; Swedish eScience Research Center; Ake Wiberg Foundation; Prostatacancerforbundet; Academy of FinlandAcademy of FinlandEuropean Commission [341967, 335976]; Cancer Foundation Finland; Google LLCGoogle Incorporated; MICCAI board challenge working group; Verily Life Sciences; EIT Health; Karolinska InstitutetKarolinska Institutet; MICCAI 2020 satellite event team; ERAPerMed [334782]

Published
2022

28. Outcome of Lung Transplantation Using Grafts From Donors Over 65 Years of Age

Author

Renard, Régis, primary, Girault, Antoine, additional, Avramenko-Bouvier, Alla, additional, Roussel, Arnaud, additional, Cerceau, Pierre, additional, Pellenc, Quentin, additional, Bunel, Vincent, additional, Godet, Cendrine, additional, Jebrak, Gilles, additional, Messika, Jonathan, additional, Montravers, Philippe, additional, Mal, Hervé, additional, Castier, Yves, additional, Mordant, Pierre, additional, Boudinet, Sandrine, additional, Jean-Baptiste, Sylvain, additional, Longrois, Dan, additional, Lortat-Jacob, Brice, additional, Tran Dinh, Alexy, additional, Hammouda, Malika, additional, Lefèvre, Lucie, additional, Savary, Alice, additional, Abadie, Agnès, additional, and Brouk, Zohra, additional

Published
2021
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30. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort

Author

Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Lille, Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Hopital Saint-Louis [AP-HP] (AP-HP), Hôpital Beaujon [AP-HP], Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpital Foch [Suresnes], Université Paris-Saclay, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Cliniques Universitaires Saint-Luc [Bruxelles], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hôpital Avicenne [AP-HP], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Hôpital Larrey [Toulouse], CHU Toulouse [Toulouse], Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, medicine.medical_specialty, lung disease, Anemia, medicine.medical_treatment, [SDV]Life Sciences [q-bio], transplant social worker, 030204 cardiovascular system & hematology, Neutropenia, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Pulmonary fibrosis, medicine, lung transplantation, Immunology and Allergy, Lung transplantation, Humans, Pharmacology (medical), Telomerase, pulmonology, Retrospective Studies, Transplantation, Lung, business.industry, fibrosis, Retrospective cohort study, Middle Aged, medicine.disease, Idiopathic Pulmonary Fibrosis, practice, 3. Good health, medicine.anatomical_structure, 030228 respiratory system, clinical research, Cohort, Mutation, business
Abstract

Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.

Published
2021
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31. Staged hybrid repair of type II thoracoabdominal aneurysms

Author

Pellenc, Quentin, primary, Roussel, Arnaud, additional, Senemaud, Jean, additional, Cerceau, Pierre, additional, Iquille, Jules, additional, Boitet, Auréline, additional, Leclere, Jean-Baptiste, additional, Milleron, Olivier, additional, Jondeau, Guillaume, additional, and Castier, Yves, additional

Published
2021
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33. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network

Abstract

Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify the predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n = 38; TERT, n = 23, TERC, n = 9, RTEL1, n = 6) between 2009 and 2018. The median age at LT was 54 years (interquartile range [IQR] 46-59); 68% were male and 71% had idiopathic pulmonary fibrosis. During the diagnosis of pulmonary fibrosis, 28 (74%) had a hematological disease, including eight with myelodysplasia. After a median follow-up of 26 months (IQR 15-46), 38 patients received LT. The overall post-LT median survival was 3.75 years (IQR 1.8-NA). The risk of death after LT was increased for patients with myelodysplasia (HR 4.1 [95% CI 1.5-11.5]) or short telomere (HR 2.2 [1.0-5.0]) before LT. After LT, all patients had anemia, 66% had thrombocytopenia, and 39% had neutropenia. Chronic lung allograft dysfunction frequency was 29% at 4 years. The present findings support the use of LT in TRG mutation carriers without myelodysplasia. Hematological evaluation should be systematically performed before LT.

Published
2021

40. Impact of donor, recipient and matching on survival after high emergency lung transplantation in France

Author

Roussel, Arnaud, primary, Sage, Edouard, additional, Massard, Gilbert, additional, Thomas, Pascal-Alexandre, additional, Castier, Yves, additional, Fadel, Elie, additional, Le Pimpec-Barthes, Françoise, additional, Maury, Jean-Michel, additional, Jougon, Jacques, additional, Lacoste, Philippe, additional, Claustre, Johanna, additional, Dahan, Marcel, additional, Pirvu, Augustin, additional, Tissot, Adrien, additional, Thumerel, Matthieu, additional, Drevet, Gabrielle, additional, Pricopi, Ciprian, additional, Le Pavec, Jérôme, additional, Mal, Hervé, additional, D'Journo, Xavier-Benoit, additional, Kessler, Romain, additional, Roux, Antoine, additional, Dorent, Richard, additional, Thabut, Gabriel, additional, and Mordant, Pierre, additional

Published
2019
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41. Long-term results of the association of covered iliac kissing stents and iliofemoral revascularizations for occlusive lesions

Author

Boulitrop, Célia, primary, Jayet, Jérémie, additional, Mouly, Charlotte, additional, Duprey, Alain, additional, Girault, Antoine, additional, Blic, Romain de, additional, Roussel, Arnaud, additional, Pellenc, Quentin, additional, Cerceau, Pierre, additional, Ben Abdallah, Iannis, additional, and Castier, Yves, additional

Published
2019
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45. Impact of Donor, Recipient and Matching on Survival After High Emergency Lung Transplantation in France

Author

Roussel, Arnaud, Sage, Edouard, Massard, Gilbert, Thomas, Pascal-Alexandre, Castier, Yves, Fadel, Elie, Le Pimpec-Barthes, Françoise, Maury, Jean-Michel, Jougon, Jacques, Lacoste, Philippe, Claustre, Johanna, Dahan, Marcel, Pirvu, Augustin, Tissot, Adrien, Thumerel, Matthieu, Drevet, Gabrielle, Pricopi, Ciprian, Le Pavec, Jérôme, Mal, Hervé, D'Journo, Xavier-Benoit, Kessler, Romain, Roux, Antoine, Dorent, Richard, Thabut, Gabriel, Mordant, Pierre, Roussel, Arnaud, Sage, Edouard, Massard, Gilbert, Thomas, Pascal-Alexandre, Castier, Yves, Fadel, Elie, Le Pimpec-Barthes, Françoise, Maury, Jean-Michel, Jougon, Jacques, Lacoste, Philippe, Claustre, Johanna, Dahan, Marcel, Pirvu, Augustin, Tissot, Adrien, Thumerel, Matthieu, Drevet, Gabrielle, Pricopi, Ciprian, Le Pavec, Jérôme, Mal, Hervé, D'Journo, Xavier-Benoit, Kessler, Romain, Roux, Antoine, Dorent, Richard, Thabut, Gabriel, and Mordant, Pierre

Abstract

Introduction: Since July 2007, the French high emergency lung transplantation (HELT) allocation procedure prioritises available lung grafts to waiting patients with imminent risk of death. The relative impacts of donor, recipient and matching on the outcome following HELT remain unknown. We aimed at deciphering the relative impacts of donor, recipient and matching on the outcome following HELT in an exhaustive administrative database. Methods: All lung transplantations performed in France were prospectively registered in an administrative database. We retrospectively reviewed the procedures performed between July 2007 and December 2015, and analysed the impact of donor, recipient and matching on overall survival after the HELT procedure by fitting marginal Cox models. Results: During the study period, 2335 patients underwent lung transplantation in 11 French centres. After exclusion of patients with chronic obstructive pulmonary disease/emphysema, 1544 patients were included: 503 HELT and 1041 standard lung transplantation allocations. HELT was associated with a hazard ratio for death of 1.41 (95% CI 1.22-1.64; p<0.0001) in univariate analysis, decreasing to 1.32 (95% CI 1.10-1.60) after inclusion of recipient characteristics in a multivariate model. A donor score computed to predict long-term survival was significantly different between the HELT and standard lung transplantation groups (p=0.014). However, the addition of donor characteristics to recipient characteristics in the multivariate model did not change the hazard ratio associated with HELT. Conclusions: This exhaustive French national study suggests that HELT is associated with an adverse outcome compared with regular allocation. This adverse outcome is mainly related to the severity status of the recipients rather than donor or matching characteristics.

Published
2019

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