Search

Objectives: Accumulating evidence suggests a direct role of Uric Acid (UA) on Left Ventricular (LV) diastolic function in chronic kidney disease and Heart Failure (HF) patients. Recently, UA has been linked to LV Hypertrophy (LVH) and Diastolic Dysfunction (DD) in women with preserved Ejection Fraction (pEF) but not in corresponding men. We sought to assess if UA could predict indices of DD in hypertensive subjects with pEF independently of gender., Method: We consecutively recruited 382 apparently healthy hypertensive subjects (age: 61.7±10.7, women: 61.3%, median EF: 64%). In 318 patients in sinus rhythm, LV mass-indexed to body surface area-was calculated (LVMI). LVH was set as an LVMI >116g/m2 or 96 g/m2 in men and women, respectively. The ratio of early transmitral peak velocity (E) to the mitral annular early diastolic velocity (Em) was used as an approximation of mean left atrial pressure (E/Em)., Results: UA [median (interquartile range): 5.4(2) mg/dl] independently predicted E/Em (adjusted coefficient: 1.01, p =0.026) while an interaction term between gender and UA was no significant (p=0.684). An ordinal score of DD was calculated taking into account increased E/Em, left atrium dilatation and LVH. Women with increased UA had 254% increased odds (adjusted OR=2.54, p=0.005) to be classified in the upper range of the DD score., Conclusion: In hypertensive subjects without HF, UA is independently associated with the presence of DD in both genders and correlates with its severity in women. Further prospective studies are warranted to evaluate the association of UA with adverse cardiovascular outcomes in high-risk populations such as HF with pEF., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

Introduction: This study aimed to evaluate the relationships between coronary flow reserve (CFR), coronary intima thickness (IT), and intima-media thickness (IMT) in hypertensive patients., Methods: Thirteen consecutive, never-treated hypertensives (mean age 59.7 years, 6 men), without left ventricular hypertrophy and with angiographically normal coronary arteries, underwent CFR measurement in the left anterior descending artery in response to a bolus intracoronary administration of adenosine, together with an optical coherence tomography (OCT) study for the estimation of IT and IMT., Results: Hypertensive patients with a low CFR (2.5, n=5) compared to those with a normal CFR (>2.5, n=8) exhibited significantly greater aortic pulse pressure (79.2 vs. 59.4 mmHg, p=0.01), while there was no difference with respect to age, sex, or left ventricular mass index (p=NS). Moreover, no difference was found between patients with low and normal CFR as regards maximal IT and IMT, or mean IT and IMT (p=NS for all). In the entire population, CFR exhibited no relationship with IT and IMT (p=NS). Finally, hypertensives with a low CFR compared to those with a normal CFR exhibited a trend towards a smaller left anterior descending area (7.8 vs. 9.5 mm(2), p=0.24)., Conclusions: In hypertensive patients without left ventricular hypertrophy, adverse functional microcirculatory changes assessed by CFR are not accompanied by OCT-estimated alterations in coronary IT and IMT.