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539 results on '"Roux, Paul"'

1. Critical spin chains and loop models with $U(n)$ symmetry

Author

Roux, Paul, Jacobsen, Jesper Lykke, Ribault, Sylvain, and Saleur, Hubert

Subjects
High Energy Physics - Theory, Mathematical Physics
Abstract

Starting with the Ising model, statistical models with global symmetries provide fruitful approaches to interesting physical systems, for example percolation or polymers. These include the $O(n)$ model (symmetry group $O(n)$) and the Potts model (symmetry group $S_Q$). Both models make sense for $n,Q\in \mathbb{C}$ and not just $n,Q\in \mathbb{N}$, and both give rise to a conformal field theory in the critical limit. Here, we study similar models based on the unitary group $U(n)$. We focus on the two-dimensional case, where the models can be described either as gases of non-intersecting orientable loops, or as alternating spin chains. This allows us to determine their spectra either by computing a twisted torus partition function, or by studying representations of the walled Brauer algebra. In the critical limit, our models give rise to a CFT with global $U(n)$ symmetry, which exists for any $n\in\mathbb{C}$. Its spectrum is similar to those of the $O(n)$ and Potts CFTs, but a bit simpler. We conjecture that the $O(n)$ CFT is a $\mathbb{Z}_2$ orbifold of the $U(n)$ CFT, where $\mathbb{Z}_2$ acts as complex conjugation., Comment: 36 pages

Published
2024

2. Can a Conversational Agent Pass Theory-of-Mind Tasks? A Case Study of ChatGPT with the Hinting, False Beliefs, and Strange Stories Paradigms

Author

Brunet-Gouet, Eric, Vidal, Nathan, Roux, Paul, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Baratgin, Jean, editor, Jacquet, Baptiste, editor, and Yama, Hiroshi, editor

Published
2024
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3. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Author

Spano, Luana, Marie-Claire, Cynthia, Godin, Ophélia, Lebras, Apolline, Courtin, Cindie, Laplanche, Jean-Louis, Leboyer, Marion, Aouizerate, Bruno, Lefrere, Antoine, Belzeaux, Raoul, Courtet, Philippe, Olié, Emilie, Dubertret, Caroline, Schwan, Raymund, Aubin, Valérie, Roux, Paul, Polosan, Mircea, Samalin, Ludovic, Haffen, Emmanuel, Bellivier, Frank, and Etain, Bruno

Published
2024
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4. Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

Author

Lengvenyte, Aiste, Aouizerate, Bruno, Aubin, Valerie, Loftus, Joséphine, Marlinge, Emeline, Belzeaux, Raoul, Dubertret, Caroline, Gard, Sebastien, Haffen, Emmanuel, Schwan, Raymund, Llorca, Pierre-Michel, Passerieux, Christine, Roux, Paul, Polosan, Mircea, Etain, Bruno, Leboyer, Marion, Courtet, Philippe, and Olié, Emilie

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < .001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.Limitations: Cross-sectional design and retrospective reporting.Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.

Published
2022
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6. The FIGO Ovulatory Disorders Classification System†

Author

Munro, Malcolm G, Balen, Adam H, Cho, SiHyun, Critchley, Hilary OD, Díaz, Ivonne, Ferriani, Rui, Henry, Laurie, Mocanu, Edgar, van der Spuy, Zephne M, Acharya, Ganesh, Adonakis, Georgios, Ahsan, Sadiah, AIhaidari, Taghreed, Asatiani, Tengiz, Azziz, Ricardo, Balen, Adam, Bedard, Michela, Blake, Jennifer, Chamy, Veronica, Cheong, Ying, Cheung, Vincent YT, Cho, Si Hyun, Critchley, Hilary, da Silva, Jose Teixeira, Diaz, Ivonne, Duncan, Colin, Ekersley, Amelie, Epifanio-Malpassii, Roberto, Famuyide, Abimbola, Giudice, Linda, Gurevich, Maargarita, Harlow, Sioban, Hart, Roger, Heikinheimo, Oskari, Heylen, Sulaiman, Kennedy, Richard, Klepchuckova, Anna, Krepelka, Petr, le Roux, Paul, Levchenko, Kateryna, Loutradis, Dimitrios, Marsh, Erica, Martins, Noni, Mathur, Raj, Matsaseng, Thabo, Miguelote, Rui, Munro, Malcolm, Ngoga, Eugene, Nisolle, Michelle, Norman, Robert, Ono, Masanori, Pintiaux, Axelle, Pristauz-Telsnigg, Gunda, Ramasauskaite, Diana, Ravn, Pernille, Reis, Jose, Roos, Peter, Rozic, Irena, Scarella, Anibal, Sharai, Katsiaryna, Shibut, Alena, Sierra, Sony, Steiner, Anne, Stoop, Dominic, Toth, Bettina, Van Der Spuy, Zephne, Williams, Saskia, Wise, Lauren, Yazdani, Anusch, Zhaunova, Liudmila, Zunckel, Meggan, and Zwane, Karabo

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Contraception/Reproduction, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Endocrinology, Female, Gynecology, Humans, Polycystic Ovary Syndrome, Pregnancy, Uterine Diseases, anovulation, ovulatory disorders, ovulatory disorders classification, ovulatory dysfunction, FIGO Committee on Menstrual Disorders and Related Health Impacts, and FIGO Committee on Reproductive Medicine, Endocrinology, and Infertility, Medical and Health Sciences, Studies in Human Society, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

Ovulatory disorders are common causes of amenorrhea, abnormal uterine bleeding and infertility and are frequent manifestations of polycystic ovary syndrome (PCOS). There are many potential causes and contributors to ovulatory dysfunction that challenge clinicians, trainees, educators, and those who perform basic, translational, clinical and epidemiological research. Similarly, therapeutic approaches to ovulatory dysfunction potentially involve a spectrum of lifestyle, psychological, medical and procedural interventions. Collaborative research, effective education and consistent clinical care remain challenged by the absence of a consensus comprehensive system for classification of these disorders. The existing and complex system, attributed to the World Health Organization (WHO), was developed more than three decades ago and did not consider more than 30 years of research into these disorders in addition to technical advances in imaging and endocrinology. This article describes the development of a new classification of ovulatory disorders performed under the aegis of the International Federation of Gynecology and Obstetrics (FIGO) and conducted using a rigorously applied Delphi process. The stakeholder organizations and individuals who participated in this process comprised specialty journals, experts at large, national, specialty obstetrical and gynecological societies, and informed lay representatives. After two face-to-face meetings and five Delphi rounds, the result is a three-level multi-tiered system. The system is applied after a preliminary assessment identifies the presence of an ovulatory disorder. The primary level of the system is based on an anatomic model (Hypothalamus, Pituitary, Ovary) that is completed with a separate category for PCOS. This core component of the system is easily remembered using the acronym HyPO-P. Each anatomic category is stratified in the second layer of the system to provide granularity for investigators, clinicians and trainees using the 'GAIN-FIT-PIE' mnemonic (Genetic, Autoimmune, Iatrogenic, Neoplasm; Functional, Infectious and Inflammatory, Trauma and Vascular; Physiological, Idiopathic, Endocrine). The tertiary level allows for specific diagnostic entities. It is anticipated that, if widely adopted, this system will facilitate education, clinical care and the design and interpretation of research in a fashion that better informs progress in this field. Integral to the deployment of this system is a periodic process of reevaluation and appropriate revision, reflecting an improved understanding of this collection of disorders.

Published
2022

7. Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, PM, Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J, Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A, Fredembach, B., Suisse, A., Denoual, Q, Polosan, M, Galliot, A.M., Brehon, L., Bonny, G, Durand, L, Feuga, V, Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A, Loftus, J., Medecin, I., Samalin, L., Llorca, PM., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Choi, Jaehyoung, Godin, Ophelia, Chernega, Timofei, Kwak, Haejin Angela, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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8. Diet quality and associations with lactate and metabolic syndrome in bipolar disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J., Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A., Fredembach, B., Suisse, A., Denoual, Q., Polosan, M., Galliot, A.M., Brehon, L., Bonny, G., Durand, L., Feuga, V., Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Samalin, L., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Godin, Ophelia, Choi, Jaehyoung, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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12. Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise - Bipolar Disorder cohort

Author

Flaudias, Valentin, Samalin, Ludovic, Godin, Ophélia, Gard, Sébastien, Brousse, Georges, Loftus, Joséphine, Aubin, Valérie, Belzeaux, Raoul, Dubertret, Caroline, Le Strat, Yann, Mazer, Nicolas, de Prémorel, Alix, Roux, Paul, Polosan, Mircea, Schwitzer, Thomas, Aouizerate, Bruno, Llorca, Pierre-Michel, Biseul, Isabelle, Etain, Bruno, Moirand, Remi, Olié, Emilie, Haffen, Emmanuel, Leboyer, Marion, Courtet, Philippe, Icick, Romain, and Guillaume, Sébastien

Published
2023
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13. Clinical characteristics associated with discrepancies between self- and clinician-rated suicidal ideation in patients with bipolar disorder (FACE-BD cohort)

Author

Nobile, Bénédicte, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, Rey, Romain, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Courtet, Philippe, and Olié, Emilie

Published
2023
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14. Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Author

Lengvenyte, Aiste, Strumila, Robertas, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, D'Amato, Thierry, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Navickas, Alvydas, Olié, Emilie, and Courtet, Philippe

Published
2023
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15. Relationships between neuropsychological performance, insight, medication adherence, and social metacognition in schizophrenia

Author

Roux, Paul, Faivre, Nathan, Urbach, Mathieu, Aouizerate, Bruno, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubertret, Caroline, Dubreucq, Julien, Fond, Guillaume, Lançon, Christophe, Leignier, Sylvain, Mallet, Jasmina, Misdrahi, David, Pires, Sylvie, Schneider, Priscille, Schurhoff, Franck, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, and Brunet-Gouet, Eric

Published
2023
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16. Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort

Author

Mallet, Jasmina, Godin, Ophélia, Mazer, Nicolas, Le Strat, Yann, Bellivier, Frank, Belzeaux, Raoul, Etain, Bruno, Fond, Guillaume, Gard, Sébastien, Henry, Chantal, Leboyer, Marion, Llorca, Pierre-Michel, Loftus, Joséphine, Olié, Emilie, Passerieux, Christine, Polosan, Mircea, Schwan, Raymund, Roux, Paul, and Dubertret, Caroline

Published
2022
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17. Vaginal misoprostol versus vaginal dinoprostone for cervical ripening and induction of labour: An individual participant data meta‐analysis of randomised controlled trials.

Author

Patabendige, Malitha, Chan, Fei, Vayssiere, Christophe, Ehlinger, Virginie, Van Gemund, Nicolette, le Cessie, Saskia, Prager, Martina, Marions, Lena, Rozenberg, Patrick, Chevret, Sylvie, Young, David C., Le Roux, Paul A., Gregson, Sarah, Waterstone, Mark, Rolnik, Daniel L., Mol, Ben W., and Li, Wentao

Subjects
INDUCED labor (Obstetrics), RANDOMIZED controlled trials, MISOPROSTOL, DINOPROSTONE, DATABASE searching
Abstract

Background: Induction of labour (IOL) is common practice and different methods carry different effectiveness and safety profiles. Objectives: To compare the effectiveness, and maternal and perinatal safety outcomes of IOL with vaginal misoprostol versus vaginal dinoprostone using individual participant data from randomised clinical trials. Search strategy: The following databases were searched from inception to March 2023: CINAHL Plus, ClinicalTrials.gov, Cochrane Pregnancy and Childbirth Group Trial Register, Ovid Embase, Ovid Emcare, Ovid MEDLINE, Scopus and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP). Selection criteria: Randomised controlled trials (RCTs), with viable singleton gestation, no language restrictions, and all published and unpublished data. Data collection and analysis: An individual participant data meta‐analysis was carried out. Main results: Ten of 52 eligible trials provided individual participant data, of which two were excluded after checking data integrity. The remaining eight trials compared low‐dose vaginal misoprostol versus dinoprostone, including 4180 women undergoing IOL, which represents 32.8% of all participants in the published RCTs. Of these, 2077 were assigned to low‐dose vaginal misoprostol and 2103 were assigned to vaginal dinoprostone. Compared with vaginal dinoprostone, low‐dose vaginal misoprostol had a comparable rate of vaginal birth. Composite adverse perinatal outcomes did not differ between the groups. Compared with vaginal dinoprostone, composite adverse maternal outcomes were significantly lower with low‐dose vaginal misoprostol (aOR 0.80, 95% CI 0.65–0.98, P = 0.03, I2 = 0%). Conclusions: Low‐dose vaginal misoprostol and vaginal dinoprostone for IOL are comparable in terms of effectiveness and perinatal safety. However, low‐dose vaginal misoprostol is likely to lead to a lower rate of composite adverse maternal outcomes than vaginal dinoprostone. This article includes Author Insights, a video abstract available at: https://vimeo.com/915799731. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Telephone Assessment of Suicidal Risk at Prehospital Emergency Medical Services: A Direct Comparison with Face-to-Face Evaluation at Psychiatric Emergency Service.

Author

Norotte, Cyrille, Zeltner, Laure, Gross, Julia, Delord, Marc, Richard, Caroline, Bembaron, Marie-Caroline, Caussanel, Jean-Marie, Herbillon, Annie, Rousseau, Christine, Chiquet, Carole, Ehly, Christine, Pain, Amandine, Vadillo, Fernando, Morisset, Laure, Roux, Paul, Passerieux, Christine, Lambert, Yves, Koukabi-Fradelizi, Mehrsa, Younes, Nadia, and Richard, Olivier

Subjects
EMERGENCY medical services, MENTAL health services, PSYCHIATRIC emergencies, SUICIDE risk assessment, RISK assessment, SUICIDE statistics, EMERGENCY medical personnel
Abstract

Assessment of suicidal risk is one of the most challenging tasks faced by health professionals, notably in emergency care. We compared telephone suicide risk assessment at prehospital Emergency Medical Services Dispatch Center (EMS-DC), with subsequent face-to-face evaluation at Psychiatric Emergency Service (PES), using French national Risk-Urgency-Danger standards (RUD). Data were collected for all suicidal adult patients (N = 80) who were addressed by EMS-DC to PES between December 2018 and August 2019 and benefited from RUD assessment at both services. Suicidal risk was given a score of 1, 2, 3 or 4, in order of severity. Mean of the differences between the RUD score at EMS-DC and PES was −0.825 (SD = 1.19), and was found to be significant (p < 0.01). The average time between RUD assessments was 420 min (SD = 448) and was negatively correlated with the difference in the RUD score (r = −0.295, p = 0.008). Associated suicide attempt increased the odds of a decrease in the RUD score (OR = 2.989; 95% CI = 1.141–8.069; p < 0.05). Telephone evaluation of suicidal risk using RUD at EMS-DC yielded moderately higher scores than those obtained by a subsequent face-to face evaluation at PES, with this difference partially explained by the time between assessments, and by clinical and contextual factors. [ABSTRACT FROM AUTHOR]

Published
2024
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19. 809 Vaginal misoprostol versus vaginal dinoprostone for labor induction: Individual participant data meta-analysis of randomized trials

Author

Patabendige, Malitha, primary, Chan, Fei, additional, Vayssiere, Christophe, additional, Ehlinger, Virginie, additional, van Gemund, Nicolette, additional, Le Cessie, Saskia, additional, Prager, Martina, additional, Marions, Lena, additional, Rozenberg, Patrick, additional, Chevret, Sylvie, additional, Young, David, additional, le Roux, Paul A., additional, Gregson, Sarah, additional, Waterstone, Mark, additional, Rolnik, Daniel L., additional, Mol, Ben Willem W., additional, and Li, Wentao, additional

Published
2024
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21. The course of bipolar disorder as a function of the presence and sequence of onset of comorbid alcohol use disorders in outpatients attending the Fondamental Advanced Centres of Expertise

Author

Icick, Romain, Gard, Sébastien, M'Bailara, Katia, Biseul, Isabelle, Samalin, Ludovic, Brousse, Georges, Flaudias, Valentin, Llorca, Pierre-Michel, Loftus, Joséphine, Cussac, Iréna, Aubin, Valérie, Schwan, Raymund, Roux, Paul, Polosan, Mircea, Courtet, Philippe, Olié, Emilie, Henry, Chantal, Mazer, Nicolas, Haffen, Emmanuel, Etain, Bruno, Leboyer, Marion, Bellivier, Frank, Belzeaux, Raoul, Godin, Ophélia, and Guillaume, Sébastien

Published
2021
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22. Pharmacological treatment profiles in the FACE-BD cohort: An unsupervised machine learning study, applied to a nationwide bipolar cohort✰

Author

Brodeur, Sébastien, Terrisse, Hugo, Pouchon, Arnaud, Godin, Ophelia, Aouizerate, Bruno, Aubin, Valerie, Bellivier, Frank, Belzeaux, Raoul, Bougerol, Thierry, Courtet, Philippe, Dubertret, Caroline, Gard, Sebastien, Haffen, Emmanuel, Henry, Chantal, Leboyer, Marion, Olié, Emilie, Roux, Paul, Samalin, Ludovic, Schwan, Raymund, Etain, Bruno, Bosson, Jean-Luc, and Polosan, Mircea

Published
2021
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23. Trajectories of medication adherence in patients with Bipolar Disorder along 2 years-follow-up

Author

Consoloni, Julia-Lou, M'Bailara, Katia, Perchec, Cyrille, Aouizerate, Bruno, Aubin, Valérie, Azorin, Jean-Michel, Bellivier, Frank, Correard, Nadia, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Gard, Sébastien, Haffen, Emmanuel, Leboyer, Marion, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Roux, Paul, Schwan, Raymund, Samalin, Ludovic, and Belzeaux, Raoul

Published
2021
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25. Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment in schizophrenia: results from the multicenter FACE-SZ cohort.

Author

Vidal, Nathan, Roux, Paul, Urbach, Mathieu, Belmonte, Cristobal, Boyer, Laurent, Capdevielle, Delphine, Clauss-Kobayashi, Julie, D’Amato, Thierry, Dassing, Romane, Dubertret, Caroline, Dubreucq, Julien, Fond, Guillaume, Honciuc, Roxana-Mihaela, Leignier, Sylvain, Llorca, Pierre-Michel, Mallet, Jasmina, Misdrahi, David, Pignon, Baptiste, Rey, Romain, and Schürhoff, Franck

Subjects
PARASYMPATHOLYTIC agents, COGNITION disorders, PSYCHIATRIC drugs, LITERATURE reviews, SCHIZOPHRENIA, SCHIZOAFFECTIVE disorders
Abstract

Aim: The anticholinergic properties of medications are associated with poorer cognitive performance in schizophrenia. Numerous scales have been developed to assess anticholinergic burden and yet, there is no consensus indicating which anticholinergic burden scale is more relevant for patients with schizophrenia. We aimed to identify valid scales for estimating the risk of iatrogenic cognitive impairment in schizophrenia. Methods: We identified 27 scales in a literature review. The responses to neuropsychological tests of 839 individuals with schizophrenia or schizoaffective disorder in the FACE-SZ database were collected between 2010 and 2021. We estimated the association between objective global cognitive performance and the 27 scales, the number of psychotropic drugs, and chlorpromazine and lorazepam equivalents in bivariable regressions in a cross-sectional design. We then adjusted the bivariable models with covariates: the predictors significantly associated with cognitive performance in multiple linear regressions were considered to have good concurrent validity to assess cognitive performance. Results: Eight scales, the number of psychotropic drugs, and drug equivalents were significantly associated with cognitive impairment. The number of psychotropic drugs, the most convenient predictor to compute, was associated with worse executive function (Standardized β = -0.12, p = .004) and reasoning (Standardized β = -0.08, p = .037). Conclusion: Anticholinergic burden, the number of psychotropic drugs, and drug equivalents were weakly associated with cognition, thus suggesting that cognitive impairment in schizophrenia and schizoaffective disorder is explained by factors other than medication. The number of psychotropic drugs was the most parsimonious method to assess the risk of iatrogenic cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Telephone Assessment of Suicidal Risk at Prehospital Emergency Medical Services: A Direct Comparison with Face-to-Face Evaluation at Psychiatric Emergency Service

Author

Norotte, Cyrille, primary, Zeltner, Laure, additional, Gross, Julia, additional, Delord, Marc, additional, Richard, Caroline, additional, Bembaron, Marie-Caroline, additional, Caussanel, Jean-Marie, additional, Herbillon, Annie, additional, Rousseau, Christine, additional, Chiquet, Carole, additional, Ehly, Christine, additional, Pain, Amandine, additional, Vadillo, Fernando, additional, Morisset, Laure, additional, Roux, Paul, additional, Passerieux, Christine, additional, Lambert, Yves, additional, Koukabi-Fradelizi, Mehrsa, additional, Younes, Nadia, additional, and Richard, Olivier, additional

Published
2023
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29. Outcome prediction with a social cognitive battery: a multicenter longitudinal study

Author

Brunet-Gouet, Eric, Decaix-Tisserand, Capucine, Urbach, Mathieu, Bazin, Nadine, Aouizerate, Bruno, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubertret, Caroline, Dubreucq, Julien, Fond, Guillaume, Lançon, Christophe, Leignier, Sylvain, Mallet, Jasmina, Misdrahi, David, Pires, Sylvie, Schneider, Priscille, Schurhoff, Franck, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, and Roux, Paul

Published
2021
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30. Validation and refinement of the clinical staging model in a French cohort of outpatient with schizophrenia (FACE-SZ)

Author

Andrianarisoa, Méja, Aouizerate, Bruno, Berna, Fabrice, Blanc, Olivier, Brunel, Lore, Bulzacka, Ewa, Capdevielle, Delphine, Chéreau-Boudet, Isabelle, Chesnoy-Servanin, Gabrielle, Danion, Jean-Marie, D'Amato, Thierry, Deloge, Arnaud, Delorme, Claire, Denizot, Hélène, Dorey, Jean-Michel, Dubertret, Caroline, Dubreucq, Julien, Faget, Catherine, Fluttaz, Cécile, Fond, Guillaume, Fonteneau, Sandrine, Gabayet, Franck, Giraud-Baro, Elisabeth, Hardy-Baylé, Marie-Christine, Lacelle, Delphine, Lançon, Christophe, Laouamri, Hakim, Leboyer, Marion, Le Gloahec, Tifenn, Le Strat, Yann, Llorca, Pierre-Michel, Mallet, Jasmina, Metairie, Emeline, Misdrahi, David, Passerieux, Christine, Peri, Pauline, Pires, Sylvie, Portalier, Céline, Rey, Romain, Roman, Céline, Sebilleau, Mathilde, Schandrin, Aurélie, Schneider, Priscille, Schurhoff, Franck, Tessier, Arnaud, Tronche, Anne-Marie, Urbach, Mathieu, Vaillant, Florence, Vehier, Aurélie, Vidailhet, Pierre, Vilà, Estelle, Yazbek, Hanan, Zinetti-Bertschy, Anna, Godin, Ophelia, Schürhoff, Frank, Boyer, Laurent, Myrtille, Andre, Andrianarisoa, Meja, Chereau, Isabelle, Lancon, Christophe, Leignier, Sylvain, Roux, Paul, and Costagliola, Dominique

Published
2019
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31. Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset

Author

Andrianarisoa, M.D., Aouizerate, B., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, P.M., Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Rey, R., Roman, C., Sebilleau, M., Schandrin, A., Schurhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Pignon, Baptiste, Lajnef, Mohamed, Godin, Ophélia, Geoffray, Marie-Maud, Rey, Romain, Mallet, Jasmina, Dubertret, Caroline, Roux, Paul, Passerieux, Christine, Marulaz, Laurent, Brunel, Lore, Dubreucq, Julien, Leignier, Sylvain, Capdevielle, Delphine, André, Myrtille, Aouizerate, Bruno, Misdrahi, David, Berna, Fabrice, Vidailhet, Pierre, Chereau, Isabelle, Llorca, Pierre-Michel, Fond, Guillaume, Lançon, Christophe, Leboyer, Marion, and Schürhoff, Franck

Published
2019
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33. Psychiatric disability as mediator of the neurocognition-functioning link in schizophrenia spectrum disorders: SEM analysis using the Evaluation of Cognitive Processes involved in Disability in Schizophrenia (ECPDS) scale

Author

Andrianarisoa, M., Aouizerate, B., Bazin, N., Berna, F., Blanc, O., Brunel, L., Bulzacka, E., Capdevielle, D., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, Jm, D'Amato, T., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Dubertret, C., Dubreucq, J., Faget, C., Fluttaz, C., Fond, G., Fonteneau, S., Gabayet, F., Giraud-Baro, E., Lacelle, D., Lançon, C., Laouamri, H., Leboyer, M., Le Gloahec, T., Le Strat, Y., Llorca, Mallet, J., Metairie, E., Misdrahi, D., Offerlin-Meyer, I., Passerieux, C., Peri, P., Pires, S., Portalier, C., Ramet, L., Rey, R., Roman, C., Schandrin, A., Schürhoff, F., Tessier, A., Tronche, Am, Urbach, M., Vaillant, F., Vehier, A., Vidailhet, P., Vilà, E., Yazbek, H., Zinetti-Bertschy, A., Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Perier, Claire-Cécile, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne-Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, and Brunet-Gouet, Eric

Published
2018
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34. Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study.

Author

Risch, Nathan, Dubois, Jonathan, Etain, Bruno, Aouizerate, Bruno, Bellivier, Frank, Belzeaux, Raoul, Dubertret, Caroline, Haffen, Emmanuel, Januel, Dominique, Leboyer, Marion, Lefrere, Antoine, Samalin, Ludovic, Polosan, Mircea, Rey, Romain, Roux, Paul, Schwan, Raymund, Walter, Michel, Courtet, Philippe, and Olié, Emilie

Subjects
LITHIUM carbonate, BIPOLAR disorder, SLEEP quality, SUICIDE risk factors, ATTEMPTED suicide
Abstract

Background. Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain. Methods. This naturalistic study included 760 subjects with BD (FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood-stabilizing blood concentration of lithium. Results. Subjects with lithium intake were less likely to report pain (odds ratio [OR] = 0.59, 95% confidence interval [CI], 0.35-0.95; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was =0.5 mmol/l (OR = 0.45, 95% CI, 0.24-0.79; p = 0.008). Conclusions. This is the first naturalistic study to show lithium's promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Author

Marie-Claire, Cynthia, primary, Spano, Luana, additional, Godin, Ophelia, additional, Lebras, Apolline, additional, Courtin, Cindie, additional, Laplanche, Jean-Louis, additional, Leboyer, Marion, additional, Aouizerate, Bruno, additional, Lefrere, Antoine, additional, Belzeaux, Raoul, additional, Courtet, Philippe, additional, Olié, Emilie, additional, Dubertret, Caroline, additional, SCHWAN, Raymund, additional, Aubin, Valérie, additional, Roux, Paul, additional, Polosan, Mircea, additional, Samalin, Ludovic, additional, haffen, emmanuel, additional, Collaborators, FondaMental Advanced Centers of Expertise in Bipolar Disorde, additional, Bellivier, Frank, additional, and Etain, Bruno, additional

Published
2023
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37. Factors associated with lamotrigine concentration/dose ratio in individuals with bipolar disorders

Author

Chouchana, Margot, primary, Delage, Clément, additional, Godin, Ophélia, additional, Fontan, Jean- Eudes, additional, Bellivier, Frank, additional, Gard, Sebastien, additional, Aubin, Valérie, additional, Belzeaux, Raoul, additional, Dubertret, Caroline, additional, Haffen, Emmanuel, additional, Leboyer, Marion, additional, Olie, Emilie, additional, Courtet, Philippe, additional, Polosan, Mircea, additional, Roux, Paul, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Lefrere, Antoine, additional, Bloch, Vanessa, additional, and Etain, Bruno, additional

Published
2023
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39. Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders.

Author

Godin, Ophélia, Leboyer, Marion, Grillault Laroche, Diane, Aubin, Valérie, Belzeaux, Raoul, Courtet, Philippe, Dubertret, Caroline, Gard, Sébastien, Haffen, Emmanuel, Olie, Emilie, Polosan, Mircea, Roux, Paul, Samalin, Ludovic, Schwan, Raymund, Bellivier, Frank, and Etain, Bruno

Subjects
DISEASE risk factors, MIGRAINE complications, THYROID diseases, CHILD abuse, CROSS-sectional method, MULTIVARIATE analysis, RISK assessment, QUESTIONNAIRES, DESCRIPTIVE statistics, RESEARCH funding, HEADACHE, DUODENAL ulcers, BIPOLAR disorder, COMORBIDITY, DISEASE complications
Abstract

Background: Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature. Methods: We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders. Results: One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset. Conclusions: This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Definition of early age at onset in bipolar disorder according to distinctive neurodevelopmental pathways: insights from the FACE-BD study.

Author

Corponi, Filippo, Lefrere, Antoine, Leboyer, Marion, Bellivier, Frank, Godin, Ophelia, Loftus, Josephine, Courtet, Philippe, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Samalin, Ludovic, Olié, Emilie, Etain, Bruno, Seriès, Peggy, and Belzeaux, Raoul

Subjects
DIAGNOSIS of bipolar disorder, REFERENCE values, PREDICTIVE tests, AGE distribution, RESEARCH methodology, AGE factors in disease, CHILD psychopathology, RESEARCH funding, DESCRIPTIVE statistics, RECEIVER operating characteristic curves, BIPOLAR disorder
Abstract

Background: Converging evidence suggests that a subgroup of bipolar disorder (BD) with an early age at onset (AAO) may develop from aberrant neurodevelopment. However, the definition of early AAO remains unprecise. We thus tested which age cut-off for early AAO best corresponds to distinguishable neurodevelopmental pathways. Methods: We analyzed data from the FondaMental Advanced Center of Expertise-Bipolar Disorder cohort, a naturalistic sample of 4421 patients. First, a supervised learning framework was applied in binary classification experiments using neurodevelopmental history to predict early AAO, defined either with Gaussian mixture models (GMM) clustering or with each of the different cut-offs in the range 14 to 25 years. Second, an unsupervised learning approach was used to find clusters based on neurodevelopmental factors and to examine the overlap between such data-driven groups and definitions of early AAO used for supervised learning. Results: A young cut-off, i.e. 14 up to 16 years, induced higher separability [mean nested cross-validation test AUROC = 0.7327 (± 0.0169) for ⩽16 years]. Predictive performance deteriorated increasing the cut-off or setting early AAO with GMM. Similarly, defining early AAO below 17 years was associated with a higher degree of overlap with data-driven clusters (Normalized Mutual Information = 0.41 for ⩽17 years) relatively to other definitions. Conclusions: Early AAO best captures distinctive neurodevelopmental patterns when defined as ⩽17 years. GMM-based definition of early AAO falls short of mapping to highly distinguishable neurodevelopmental pathways. These results should be used to improve patients' stratification in future studies of BD pathophysiology and biomarkers. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Can a conversational agent pass theory-of-mind tasks? A case study of ChatGPT with the Hinting, False Beliefs, and Strange Stories paradigms

Author

Brunet-Gouet, Eric, Vidal, Nathan, and Roux, Paul

Subjects
ChatGPT, False Beliefs, theory-of-mind, indirect speech
Abstract

We investigate the possibility that the recently proposed OpenAI’s ChatGPT conversational agent could be examined with classical theory-of-mind paradigms. We used an indirect speech understanding task, the hinting task, a new text version of a False Belief/False Photographs paradigm, and the Strange Stories paradigm. The hinting task is usually used to assess individuals with autism or schizophrenia by requesting them to infer hidden intentions from short conversations involving two characters. In a first experiment, ChatGPT 3.5 exhibits quite limited performances on the Hinting task when either original scoring or revised rating scales are used. We introduced slightly modified versions of the hinting task in which either cues about the presence of a communicative intention were added or a specific question about the character’s intentions were asked. Only the latter demonstrated enhanced performances. No dissociation between the conditions was found. The Strange Stories were associated with correct performances but we could not be sure that the algorithm had no prior knowledge of the test. In the second experiment, the most recent version of ChatGPT (4-0314) exhibited better performances in the Hinting task, although they did not match the average scores of healthy subjects. In addition, the model could solve first and second order False Beliefs tests but failed on items with reference to a physical property like object visibility or more complex inferences. This work offers an illustration of the possible application of psychological constructs and paradigms to a conversational agent of a radically new nature., Updated version of the study (first version: Feb 13, 2023, DOI : 10.5281/zenodo.7637476) with a second experiment.

Published
2023
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42. Confidence in visual detection, familiarity and recollection judgements is preserved in schizophrenia spectrum disorder

Author

Rouy, Martin, primary, Pereira, Michael, additional, Saliou, Pauline, additional, Sanchez, Rémi, additional, el Mardi, Wassila, additional, Sebban, Hanna, additional, Baqué, Eugénie, additional, Dezier, Childéric, additional, Porte, Perrine, additional, Micaux, Julia, additional, de Gardelle, Vincent, additional, Mamassian, Pascal, additional, Moulin, Chris J.A., additional, Dondé, Clément, additional, Roux, Paul, additional, and Faivre, Nathan, additional

Published
2023
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46. Definition of early age at onset in bipolar disorder according to distinctive neurodevelopmental pathways:Insights from the FACE-BD study

Author

Corponi, Filippo, Lefrere, Antoine, Leboyer, Marion, Bellivier, Frank, Godin, Ophelia, Loftus, Josephine, Courtet, Philippe, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Samalin, Ludovic, Olié, Émilie, Etain, Bruno, Seriès, Peggy, Belzeaux, Raoul, University of Edinburgh, Assistance Publique - Hôpitaux de Marseille (APHM), Fondation FondaMental [Créteil], Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Princesse Grace, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), CHU Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Psychothérapique de Nancy [Laxou] (CPN), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Pôle Digestif [CHRU Montpellier]

Subjects
bipolar disorder, machine learning, neurodevelopment, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Age at onset, age at onset
Abstract

BackgroundConverging evidence suggests that a subgroup of bipolar disorder (BD) with an early age at onset (AAO) may develop from aberrant neurodevelopment. However, the definition of early AAO remains unprecise. We thus tested which age cut-off for early AAO best corresponds to distinguishable neurodevelopmental pathways.MethodsWe analyzed data from the FondaMental Advanced Center of Expertise-Bipolar Disorder cohort, a naturalistic sample of 4421 patients. First, a supervised learning framework was applied in binary classification experiments using neurodevelopmental history to predict early AAO, defined either with Gaussian mixture models (GMM) clustering or with each of the different cut-offs in the range 14 to 25 years. Second, an unsupervised learning approach was used to find clusters based on neurodevelopmental factors and to examine the overlap between such data-driven groups and definitions of early AAO used for supervised learning.ResultsA young cut-off, i.e. 14 up to 16 years, induced higher separability [mean nested cross-validation test AUROC = 0.7327 (± 0.0169) for ⩽16 years]. Predictive performance deteriorated increasing the cut-off or setting early AAO with GMM. Similarly, defining early AAO below 17 years was associated with a higher degree of overlap with data-driven clusters (Normalized Mutual Information = 0.41 for ⩽17 years) relatively to other definitions.ConclusionsEarly AAO best captures distinctive neurodevelopmental patterns when defined as ⩽17 years. GMM-based definition of early AAO falls short of mapping to highly distinguishable neurodevelopmental pathways. These results should be used to improve patients' stratification in future studies of BD pathophysiology and biomarkers.

Published
2023

47. Physical and Mental Health Status of Former Smokers and Non-Smokers Patients with Bipolar Disorder

Author

Nobile, Bénédicte, Godin, Ophélia, Gard, Sébastien, Samalin, Ludovic, Brousse, Georges, Loftus, Joséphine, Aubin, Valérie, Belzeaux, Raoul, Dubertret, Caroline, Le Strat, Yann, Mazer, Nicolas, Prémorel, Alix, Roux, Paul, Polosan, Mircea, Schwintzer, Thomas, Llorca, Pierre-Michel, Biseul, Isabelle, Etain, Bruno, Moirand, Remi, Olié, Emilie, Haffen, Emmanuel, Leboyer, Marion, Courtet, Philippe, Guillaume, Sébastien, Icick, Romain, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Fondation FondaMental [Créteil], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Hospitalier Princesse Grace, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Psychothérapique de Nancy [Laxou] (CPN), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Psychiatry and Mental health, substance use disorders, Bipolar disorder, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Tobacco, Addiction, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Former smokers, metabolic syndrome
Abstract

International audience; Objectives Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and non-psychiatric correlates of tobacco smoking status (never- versus current vs former smokers) in individuals with BD.Methods 3,860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g. BD type, current symptoms load, and non-psychiatric morbidity \textendash including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied.Results Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers \textendash suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics.Conclusions Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.

Published
2023

50. Auteurs

Author

Abdel-Baki, Amal, primary, Amado, Isabelle, additional, Arfeuillère, Sophie, additional, Arnaud, Ingrid, additional, Arthur, Maïté, additional, Babinet, Marie-Noëlle, additional, Bazin, Nadine, additional, Bellier-Teichmann, Tanja, additional, Bismuth, Corinne, additional, Blain-Pierre, Fabienne, additional, Bloch, Pascal, additional, Bogey, Alice, additional, Bonilla-Guerrero, Julien, additional, Bonsack, Charles, additional, Borrel, Béatrice, additional, Boulon, Yann, additional, Bourlier, Emmanuelle, additional, Bralet, Marie-Cécile, additional, Brana, Armando, additional, Brénugat-Herné, Lindsay, additional, Brousse, Georges, additional, Brunet, Éric, additional, Bulzacka, Eva, additional, Cady, Florian, additional, Callot, Jérémy, additional, Caria, Aude, additional, Cellard, Caroline, additional, Cervello, Sophie, additional, Chambon, Valérian, additional, Charrier, Philippe, additional, Chatelard, Fabienne, additional, Conus, Philippe, additional, Corbière, Marc, additional, Danset-Alexandre, Charlotte, additional, Deegan, Patricia, additional, Delourme, Gwenaelle, additional, Dematteis, Maurice, additional, Demily, Caroline, additional, Destaillats, Jean-Marc, additional, Duboc, Chloé, additional, Dubreucq, Julien, additional, Dubrulle, Aurélie, additional, Dupuis, Marie, additional, Durand, Bernard, additional, Ensenlaz, Xavier, additional, Faraldo, Mégane, additional, Farhat, Sarah-Lise, additional, Favre, Émilie, additional, Favrod, Jérôme, additional, Franck, Nicolas, additional, François, Guillaume, additional, Frankhauser, Adeline, additional, Fredericks, Jennifer, additional, Frobert, Laurent, additional, Fulachier, Delphine, additional, Gabayet, Franck, additional, Gaudelus, Baptiste, additional, Gautier, Corinne, additional, Gayton, Roger, additional, Giordana, Jean-Yves, additional, Baro, Élisabeth Giraud, additional, Gobbo, Julien, additional, Gozlan, Guy, additional, Greacen, Tim, additional, Gremaud, Katya, additional, Grivet, Isabelle, additional, Guy, Cyrielle, additional, Germaneau, Ghina Harika, additional, Hochard, Christophe, additional, Hodé, Yann, additional, Ismailaj, Alban, additional, Jaafari, Nematollah, additional, Jobert, Éliane, additional, Jossserand, Anne-Claire, additional, Jouet, Emmanuelle, additional, Kaliuzhna, Mariia, additional, Khazaal, Yasser, additional, Klein, Rémy, additional, Koubichkine, Alexandra, additional, Kulsa, Mila Kirstie, additional, Lagasse, Stéphanie, additional, Lama-Lama, Pablo, additional, Lambert, Thierry, additional, Lançon, Christophe, additional, Launay, Corinne, additional, Lecardeur, Laurent, additional, Le Cardinal, Patrick, additional, Lecomte, Tania, additional, Leguay, Denis, additional, Leignier, Sylvain, additional, Lindenmayer, Jean-Pierre, additional, Loubières, Céline, additional, Lucas, Thierry, additional, Maillebuau, Mathilde, additional, Malangin, Brigitte, additional, Marsili, Massimo, additional, Martin, Brice, additional, Martin, Juliette, additional, Massoubre, Catherine, additional, Maugiron, Philippe, additional, Medalia, Alice, additional, Melis, Fanny, additional, Meunier-Cussac, Sophie, additional, Morandi, Stéphane, additional, Morin, Laurent, additional, Ngakui, Anne, additional, Nguyen, Alexandra, additional, Oker, Ali, additional, Orens, Sandrine, additional, Pachoud, Bernard, additional, Passerieux, Christine, additional, Pellet, Jacques, additional, Pellet, Joanie, additional, Penn, David, additional, Pennel, Lucie, additional, Périer, Claire-Cécile, additional, Petitjean, François, additional, Peyroux, Élodie, additional, de Pierrefeu, Inès, additional, Planas, Pedro, additional, Plane, Morgane, additional, Pomini, Valentino, additional, Pousthomis, Malgorzata, additional, Prouteau, Antoinette, additional, Quilès, Clélia, additional, Raffard, Stéphane, additional, Rebelle, Sandrine, additional, Reeder, Clare, additional, Regnier, Jennifer, additional, Rengade, Charles-Édouard, additional, Revil, Katia, additional, Ridders, Jean-François, additional, Rigaut, Bérangère, additional, Rivet, Amandine, additional, R-Mercier, Alexandra, additional, Rochet, Cécile, additional, Roelandt, Jean-Luc, additional, Roussel, Céline, additional, Roux, Paul, additional, Salas-Toquero, Caroline, additional, Schoendorff, Marianne, additional, Staedel, Bérénice, additional, Thibaudeau, Élisabeth, additional, Todd, Aurélia, additional, Todoroff, Floriane, additional, Van der Henst, Jean-Baptiste, additional, Vanzetti, Marie, additional, Verdoux, Hélène, additional, Vianin, Pascal, additional, Vidon, Gilles, additional, Willard, Dominique, additional, Wykes, Til, additional, and Younès, Nadia, additional

Published
2018
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