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5. Access to phage therapy at Hospices Civils de Lyon in 2022: Implementation of the PHAGEinLYON Clinic programme

Author

Ferry, Tristan, Le Bouar, Myrtille, Briot, Thomas, Roussel-Gaillard, Tiphaine, Perpoint, Thomas, Roux, Sandrine, Valour, Florent, Javaux, Clément, Wan, Marie, Conrad, Anne, Becker, Agathe, Triffault-Fillit, Claire, Simon, Marie, Braun, Evelyne, Van der Bogaart, Lorena, Chauvelot, Pierre, Bahuaud, Olivier, Landre, Sophie, Soueges, Sarah, Eberl, Isabelle, Dallosto, Karine, Boulant, Johanna, Marrocco, Nathalie, Ader, Florence, Lustig, Sébastien, Batailler, Cécile, Schmidt, Axel, Craighero, Fabien, Fleury, Andréa, El-Ameen, Ali, Schleef, Arnaud, Miailhes, Jade, Fustier, Anne, Himpens, Paul-Henri, Boussel, Loïc, Buisson, Marielle, Boussaha, Inesse, Kassai, Berhouz, Bouar, Myrtille Le, Kassai, Behrouz, and Ndiaye, Marietou

Published
2024
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6. ANTIFON-CLIC®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?

Author

Bienvenu, Anne-Lise, primary, Leray, Véronique, additional, Guichon, Céline, additional, Bourget, Stéphanie, additional, Chapuis, Claire, additional, Duréault, Amélie, additional, Pavese, Patricia, additional, Roux, Sandrine, additional, Kahale, Elham, additional, Chaabane, Wajih, additional, Subtil, Fabien, additional, Maucort-Boulch, Delphine, additional, Talbot, François, additional, Dode, Xavier, additional, Ghesquières, Hervé, additional, and Leboucher, Gilles, additional

Published
2023
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9. HHV-6 infection after allogeneic hematopoietic stem cell transplantation: From chromosomal integration to viral co-infections and T-cell reconstitution patterns

Author

Ader, F., Bachy, E., Balsat, M., Barraco, F., Bienvenu, A.L., Billaud, G., Biron, F., Boibieux, A., Chidiac, C., Conrad, A., Ducastelle-Leprêtre, S., Dumitrescu, O., Dupont, D., Escuret, V., Ferry, T., Frobert, E., Gilis, L., Grateau, A., Heiblig, M., Labussière-Wallet, H., Le Maréchal, M., Lebras, L., Lina, B., Lina, G., Quintela, A., Miailhes, P., Michallet, A.-S., Michallet, M., Michallet, M.-C., Monneret, G., Morfin-Sherpa, F., Nicolini, F.E., Perpoint, T., Peyrouse de Montclos, M., Picot, S., Poitevin-Later, F., Ranc, A.G., Roux, S., Salles, G., Saison, J., Sénéchal, A., Sobh, M., Thomas, X., Valour, F., Wattel, E., Quintela, Adrien, Escuret, Vanessa, Roux, Sandrine, Bonnafous, Pascale, Gilis, Lila, Barraco, Fiorenza, Labussière-Wallet, Hélène, Duscastelle-Leprêtre, Sophie, Nicolini, Franck-Emmanuel, Thomas, Xavier, Chidiac, Christian, Ferry, Tristan, Frobert, Emilie, Morisset, Stéphane, Poitevin-Later, Françoise, Monneret, Guillaume, Michallet, Mauricette, and Ader, Florence

Published
2016
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11. Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

Author

Bienvenu, A.L., primary, Pradat, P., additional, Matusik, E., additional, Piriou, V., additional, Rimmelé, T., additional, Parant, F., additional, Tod, M., additional, Leboucher, G., additional, Goutelle, S., additional, Ader, Florence, additional, Argaud, Laurent, additional, Aubrun, Frédéric, additional, Fellahi, Jean-Luc, additional, Guichon, Céline, additional, Juillard, Laurent, additional, Leclerc, Vincent, additional, Miossec, Charline, additional, Paillet, Carole, additional, Plesa, Alexandra, additional, Richard, Jean-Christophe, additional, Roux, Sandrine, additional, and Wallet, Florent, additional

Published
2023
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12. Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

Author

Ader, Florence, Argaud, Laurent, Aubrun, Frédéric, Fellahi, Jean-Luc, Guichon, Céline, Juillard, Laurent, Leclerc, Vincent, Miossec, Charline, Paillet, Carole, Plesa, Alexandra, Richard, Jean-Christophe, Roux, Sandrine, Wallet, Florent, Bienvenu, A.L., Pradat, P., Matusik, E., Piriou, V., Rimmelé, T., Parant, F., Tod, M., Leboucher, G., and Goutelle, S.

Published
2023
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14. Practical checklist for implementation of antifungal stewardship programmes

Author

Bienvenu, Anne-Lise, primary, Pavese, Patricia, additional, Leboucher, Gilles, additional, Berger, Pierre, additional, Roux, Sandrine, additional, Charmillon, Alexandre, additional, Foroni, Luc, additional, Menotti, Jean, additional, Lebeaux, David, additional, Mayan, Rémi, additional, Mondain, Véronique, additional, Robin, Christine, additional, Lesprit, Philippe, additional, Alfandari, Serge, additional, and Kernéis, Solen, additional

Published
2022
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15. Disappearance of FDG uptake on PET scan after antimicrobial therapy could help for the diagnosis of Coxiella burnetii spondylodiscitis

Author

Gaudé, Marine, Julien, Saison, Laurent, Frédéric, Ferry, Tristan, Perpoint, Thomas, Boibieux, André, Biron, François, Ader, Florence, Valour, Florent, Roux, Sandrine, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Vallat, Marie-Paule, Miailhes, Patrick, Chidiac, Christian, Gillet, Yves, Hees, Laure, Lustig, Sébastien, Neyret, Philippe, Reynaud, Olivier, Peltier, Adrien, Viste, Anthony, Bérard, Jean-Baptiste, Dalat, Frédéric, Cantin, Olivier, Desmarchelier, Romain, Vermersch, Thibault, Fessy, Michel-Henry, Barrey, Cédric, Signorelli, Francesco, Jouanneau, Emmanuel, Jacquesson, Timothée, Mojallal, Ali, Boucher, Fabien, Shipkov, Hristo, Ismail, Mehdi, Chateau, Joseph, Vandenesch, François, Rasigade, Jean-Philippe, Dupieux, Céline, Trouillet-Assant, Sophie, Morelec, Isabelle, Janier, Marc, Giammarile, Francesco, Tod, Michel, Gagnieu, Marie-Claude, Goutelle, Sylvain, and Mabrut, Eugénie

Published
2016
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16. Pristinamycin in the treatment of MSSA bone and joint infection

Author

Valour, Florent, Boibieux, André, Karsenty, Judith, Vallat, Marie-Paule, Braun, Evelyne, Perpoint, Thomas, Biron, François, Laurent, Frédéric, Lustig, Sébastien, Chidiac, Christian, Ferry, Tristan, Ader, Florence, Biron, François, Boibieux, André, Braun, Evelyne, Chidiac, Christian, Daoud, Fatiha, Ferry, Tristan, Gillet, Yves, Hees, Laure, Lippmann, Johanna, Miailhes, Patrick, Perpoint, Thomas, Roux, Sandrine, Saison, Julien, Vallat, Marie-Paule, Valour, Florent, Barrey, Cédric, Bérard, Jean-Baptiste, Boucher, Fabien, Breton, Pierre, Cantin, Olivier, Dalat, Frédéric, Desmarchelier, Romain, Fessy, Michel-Henry, Jacquesson, Timothée, Jouanneau, Emmanuel, Lustig, Sébastien, Mojallal, Ali, Neyret, Philippe, Peltier, Adrien, Reynaud, Olivier, Shipkov, Hristo, Signorelli, Francesco, Vermersch, Thibault, Viste, Anthony, Dupieux, Céline, Laurent, Frederic, Rasigade, Jean-Philippe, Vandenesch, François, Giammarile, Francesco, Janier, Marc, Morelec, Isabelle, Gagnieu, Marie-Claude, Goutelle, Sylvain, Tod, Michel, and Mabrut, Eugénie

Published
2016
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18. Implementation of a complex bone and joint infection phage therapy centre in France: lessons to be learned after 4 years' experience

Author

Ferry, Tristan, primary, Kolenda, Camille, additional, Briot, Thomas, additional, Lustig, Sébastien, additional, Leboucher, Gilles, additional, Laurent, Frédéric, additional, Ferry, Tristan, additional, Valour, Florent, additional, Perpoint, Thomas, additional, Ader, Florence, additional, Roux, Sandrine, additional, Becker, Agathe, additional, Triffault-Fillit, Claire, additional, Conrad, Anne, additional, Pouderoux, Cécile, additional, Chauvelot, Pierre, additional, Chabert, Paul, additional, Lippman, Johanna, additional, Braun, Evelyne, additional, Servien, Elvire, additional, Batailler, Cécile, additional, Gunst, Stanislas, additional, Schmidt, Axel, additional, Sappey-Marinier, Eliott, additional, Ode, Quentin, additional, Fessy, Michel-Henry, additional, Viste, Anthony, additional, Besse, Jean-Luc, additional, Chaudier, Philippe, additional, Louboutin, Lucie, additional, Van Haecke, Adrien, additional, Mercier, Marcelle, additional, Belgaid, Vincent, additional, Gazarian, Aram, additional, Walch, Arnaud, additional, Bertani, Antoine, additional, Rongieras, Frédéric, additional, Martres, Sébastien, additional, Trouillet, Franck, additional, Barrey, Cédric, additional, Mojallal, Ali, additional, Brosset, Sophie, additional, Hanriat, Camille, additional, Person, Hélène, additional, Céruse, Philippe, additional, Fuchsmann, Carine, additional, Gleizal, Arnaud, additional, Aubrun, Frédéric, additional, Dziadzko, Mikhail, additional, Macabéo, Caroline, additional, Patrascu, Dana, additional, Beraud, Laetitia, additional, Roussel-Gaillard, Tiphaine, additional, Dupieux, Céline, additional, Josse, Jérôme, additional, Craighero, Fabien, additional, Boussel, Loic, additional, Pialat, Jean-Baptiste, additional, Morelec, Isabelle, additional, Tod, Michel, additional, Gagnieu, Marie-Claude, additional, Goutelle, Sylvain, additional, Mabrut, Eugénie, additional, Medina, Mathieu, additional, Laumay, Floriane, additional, Bonhomme, Melanie, additional, Blazere, Leslie, additional, Legendre, Tiphaine, additional, Terrazzoni, Eline, additional, Pirot, Fabrice, additional, Merienne, Camille, additional, Filali, Samira, additional, and Lapras, Benjamine, additional

Published
2022
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19. Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference

Author

Garreau, Romain, Bricca, Romain, Gagnieu, Marie-Claude, Roux, Sandrine, Conrad, Anne, Bourguignon, Laurent, Ferry, Tristan, Goutelle, Sylvain, Valour, Florent, Perpoint, Thomas, Miailhes, Patrick, Ader, Florence, Becker, Agathe, Triffault-Fillit, Claire, Pouderoux, Cécile, Benech, Nicolas, Chauvelot, Pierre, Perry, Marielle, Daoud, Fatiha, Lippman, Johanna, Braun, Evelyne, Chidiac, Christian, Servien, Elvire, Lustig, Sébastien, Batailler, Cécile, Gunst, Stanislas, Schmidt, Axel, Malatray, Matthieu, Sappey-Marinier, Elliot, Fessy, Michel-Henry, Viste, Anthony, Besse, Jean-Luc, Chaudier, Philippe, Louboutin, Lucie, Ode, Quentin, van Haecke, Adrien, Mercier, Marcelle, Belgaid, Vincent, Walch, Arnaud, Martres, Sébastien, Trouillet, Franck, Barrey, Cédric, Mojallal, Ali, Brosset, Sophie, Hanriat, Camille, Person, Hélène, Sigaux, Nicolas, Céruse, Philippe, Fuchsmann, Carine, Aubrun, Frédéric, Dziadzko, Mikhail, Macabéo, Caroline, Laurent, Frederic, Beraud, Laetitia, Roussel-Gaillard, Tiphaine, Dupieux, Céline, Kolenda, Camille, Josse, Jérôme, Brevet, Marie, Trecourt, Alexis, Craighero, Fabien, Boussel, Loic, Pialat, Jean-Baptiste, Morelec, Isabelle, Tod, Michel, Mabrut, Eugénie, Hospices Civils de Lyon (HCL), Lyon Bone and Joint Infection Study Group (BJI), Hôpital Nord-Ouest de Villefranche-sur-Saône, Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre interrégional de référence Rhône-Alpes - Auvergne des infections ostéo-articulaires complexes, Institut des Sciences Pharmaceutiques et Biologiques (ISPB), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, Population, MESH: Daptomycin, 03 medical and health sciences, 0302 clinical medicine, Daptomycin, Pharmacokinetics, MESH: Drug Monitoring, Internal medicine, MESH: Anti-Bacterial Agents, medicine, polycyclic compounds, Humans, Pharmacology (medical), 030212 general & internal medicine, Dosing, education, Pharmacology, Volume of distribution, Sex Characteristics, education.field_of_study, MESH: Humans, medicine.diagnostic_test, business.industry, Drug interaction, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, bacterial infections and mycoses, MESH: Rifampin, MESH: Male, Anti-Bacterial Agents, Infectious Diseases, Therapeutic drug monitoring, Female, Drug Monitoring, Rifampin, business, MESH: Female, Rifampicin, medicine.drug, MESH: Sex Characteristics
Abstract

Background Daptomycin is increasingly used in the treatment of bone and joint infection (BJI), but its pharmacokinetics (PK) and dosage requirements have not been thoroughly investigated in this indication. Daptomycin may be co-administered with rifampicin, which raises questions about a potential drug interaction. Objectives To investigate the population PK and dosage requirements of daptomycin in patients with BJI, and examine the influence of rifampicin co-administration. Methods A population approach was used to analyse PK data from patients who received daptomycin in our regional reference for BJI. We examined the influence of available covariates, including rifampicin co-administration on daptomycin PK. Simulations performed with the final model investigated the influence of dosages and covariates on PTA for both efficacy and safety. Results A total of 1303 daptomycin concentrations from 183 patients were analysed. A two-compartment model best described the data. Significant intra-individual variability was observed. Daptomycin clearance was influenced by renal function and sex, with females having a 26% lower typical clearance than males. Central volume of distribution (V1) was influenced by body weight, age, sex and rifampicin co-administration. Typical V1 was 11% lower in patients who were co-administered rifampicin. In PK/PD simulations, sex influenced the probability of AUC24/MIC target attainment, while rifampicin had a marginal effect. Conclusions A daptomycin dosage of 8 mg/kg/24 h in women and 10 mg/kg/24 h in men should optimize efficacy but may lead to excessive trough concentrations in many patients, especially in women. Therapeutic drug monitoring appears necessary for precision dosing of daptomycin.

Published
2021
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20. Type I IFN immunoprofiling in COVID-19 patients

Author

Mouton, William, Oriol, Guy, Compagnon, Christelle, Generenaz, Laurence, Cheynet, Valérie, Ader, Florence, Becker, Agathe, Benech, Nicholas, Chauvelot, Pierre, Chidiac, Christian, Conrad, Anne, Ferry, Tristan, Miailhes, Patrick, Perpoint, Thomas, Perry, Marielle, Pouderoux, Cécile, Roux, Sandrine, Triffault-Fillit, Claire, Valour, Florent, Hodane, Yonis, Chauvelot, Louis, Chabert, Paul, Provoost, Judith, David, Guillaume, Folliet, Laure, Lecam, Pierre, Billaud, Geneviève, Bouscambert, Maude, Escuret, Vanessa, Frobert, Emilie, Bal, Antonin, Destras, Grégory, Josset, Laurence, Morfin, Florence, Munier, Clément, Valette, Martine, Venet, Fabienne, Garnier, Lorna, Pescarmona, Rémi, Lombard, Christine, Walzer, Thierry, Trouillet-Assant, Sophie, Viel, Sebastien, Gaymard, Alexandre, Pons, Sylvie, Richard, Jean-Christophe, Perret, Magali, Villard, Marine, Brengel-Pesce, Karen, Lina, Bruno, Mezidi, Mehdi, Bitker, Laurent, and Belot, Alexandre

Published
2020
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22. Safety of Tedizolid as Suppressive Antimicrobial Therapy for Patients With Complex Implant-Associated Bone and Joint Infection due to Multidrug-Resistant Gram-Positive Pathogens: Results From the TediSAT Cohort Study

Author

Ferry, Tristan, Conrad, Anne, Senneville, Eric, Roux, Sandrine, Dupieux-Chabert, Céline, Dinh, Aurélien, Lustig, Sebastien, Goutelle, Sylvain, Briot, Thomas, Pham, Truong-Thanh, Valour, Florent, Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Faculté de Médecine Henri Warembourg - Université de Lille, Hôpital Ambroise Paré [AP-HP], Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Gustave Eiffel

Subjects
LINEZOLID, TEDIZOLID, [SDV.IMM]Life Sciences [q-bio]/Immunology, SUPPRESSIVE ANTIMICROBIAL THERAPY, BONE AND JOINT INFECTION, PERIPROSTHETIC JOINT INFECTION
Abstract

A prospective cohort study was conducted to evaluate long-term safety of tedizolid as suppressive antimicrobial treatment in patients with implant-associated bone and joint infection caused by multidrug-resistant gram-positive pathogens. Seventeen patients received tedizolid with a median duration of treatment of 6 months. No patients developed a serious adverse event.

Published
2021
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23. Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period.

Author

Danjou, William, Chabert, Paul, Perpoint, Thomas, Pradat, Pierre, Miailhes, Patrick, Boibieux, André, Becker, Agathe, Fuchsmann, Carine, Laurent, Frédéric, Tringali, Stephane, Roux, Sandrine, Triffault-Fillit, Claire, Valour, Florent, Ferry, Tristan, Group, Lyon Bone and Joint Infection Study, and Lyon Bone and Joint Infection Study Group

Subjects
OTITIS externa, ARTHRITIS Impact Measurement Scales, DIABETES, RETROSPECTIVE studies, DISEASE relapse, OSTEOMYELITIS, PSEUDOMONAS diseases, IMPACT of Event Scale, PSEUDOMONAS
Abstract

Background: Necrotizing external otitis (NEO) is a severe infection of the skull base that occurs generally in the elderly and/or in diabetic recipients. There are few data in the literature about the therapeutic management of this complex bone infection.Objectives: To analyse relapses after NEO treatment completion, and to describe the clinical features of NEO.Methods: We performed a retrospective cohort study in the Lyon regional reference centre for the management of complex bone and joint infections. Consecutive cases of NEO from 1 January 2006 to 31 December 2018 were included. The primary outcome was the relapse of NEO. Variables were analysed using Cox regression survival analysis with adjusted hazard ratio (aHR) and Kaplan-Meier curve.Results: Sixty-six patients were included. Median age was 75 (IQR 69-81) years and 46 (70%) patients were diabetic. Eleven patients (17%) had temporomandibular arthritis, 10 (15%) cranial nerve paralysis, 2 (3%) cerebral thrombophlebitis, and 2 (3%) contiguous abscess. Microbiological documentation was obtained in 56 patients and revealed Pseudomonas aeruginosa in 44/56 patients (79%). Nine (14%) cases had no microbiological documentation. Antibiotic therapy was dual for 63 (95%) patients. During a median follow-up of 27 (IQR 12-40) months, 16 out of 63 (25%) patients experienced a relapse. Fungal infection was significantly associated with relapse [aHR 4.1 (95% CI 1.1-15); P = 0.03].Conclusions: NEO is a severe bone infection, mainly (but not exclusively) caused by P. aeruginosa, which occurs in elderly and diabetic recipients. Fungal infections at baseline significantly impact the outcome. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Cluster of Coronavirus Disease 2019 (COVID-19) in the French Alps, February 2020

Author

Danis, Kostas, Epaulard, Olivier, Bénet, Thomas, Gaymard, Alexandre, Campoy, Séphora, Botelho-Nevers, Elisabeth, Bouscambert-Duchamp, Maude, Spaccaferri, Guillaume, Ader, Florence, Mailles, Alexandra, Boudalaa, Zoubida, Tolsma, Violaine, Berra, Julien, Vaux, Sophie, Forestier, Emmanuel, Landelle, Caroline, Fougere, Erica, Thabuis, Alexandra, Berthelot, Philippe, Veil, Raphael, Levy-Bruhl, Daniel, Chidiac, Christian, Lina, Bruno, Coignard, Bruno, Saura, Christine, Brottet, Elise, Casamatta, Delphine, Gallien, Yves, George, Scarlett, Viriot, Delphine, Ait Belghiti, Fatima, Bernard-Stoecklin, Sibylle, Desenclos, Jean-Claude, Giese, Coralie, Ghislain, Didier, Gounon, Magali, Grangeret, Nathalie, Marie, Cécile, Morel, Bruno, Deher, Muriel, Ronnaux Baron, Anne-Sophie, Courbis, Geneviève, Ragozin, Nathalie, Wolska, Monika, Serange, Eric, Mercatello, Delphine, Aiouaz, Soraya, Valette, Martine, Frobert, Emilie, Josset, Laurence, Escuret, Vanessa, Morfin, Florence, Billaud, Geneviève, Blanc, Myriam, Arata-Bardet, Julie, Froidure, Marie, Le Maréchal, Marion, Pavese, Patricia, Pierre, Isabelle, Becker, Agathe, Chauvelot, Pierre, Conrad, Anne, Ferry, Tristan, Miailhes, Patrick, Perpoint, Thomas, Pouderoux, Cécile, Roux, Sandrine, Valour, Florent, Lutz, Marie-France, Pouvaret, Anne, Vitrat, Virginie, Maillet, Mylène, Janssen, Cécile, Piet, Emilie, Bosch, Alexie, Destrem, Anne-Laure, Isnard, Margaux, Challan-Belval, Thibault, Wackenheim, Chloe, Couturier, Alice, Gheno, Gael, Roupioz, Thierry, Lucet, Nicolas, Ayouni, Stéphane, Vincent, Mireille, de Epidemiología, Servicio, General de Salud Pública del Gover Balear, Dirección, Masserey Spicher, Virginie, Bourquin, Catherine, Stoll, Jeanine, Chaud, Pascal, and Mounayar, Anne-Laure

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Attack rate, Pneumonia, Viral, coronavirus, Disease cluster, Asymptomatic, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, 030225 pediatrics, medicine, Major Article, Cluster Analysis, Humans, Serologic Tests, 030212 general & internal medicine, cluster, Index case, Pandemics, Aged, Retrospective Studies, Aged, 80 and over, Transmission (medicine), business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, infection, AcademicSubjects/MED00290, Infectious Diseases, Coinfection, Female, France, medicine.symptom, business, Coronavirus Infections, Viral load
Abstract

BackgroundOn 7 February 2020, French Health authorities were informed of a confirmed case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected in Singapore who had recently stayed in a chalet in the French Alps. We conducted an investigation to identify secondary cases and interrupt transmission.MethodsWe defined as a confirmed case a person linked to the chalet with a positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2.ResultsThe index case stayed 4 days in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in 5 individuals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the chalet: 75%). One pediatric case, with picornavirus and influenza A coinfection, visited 3 different schools while symptomatic. One case was asymptomatic, with similar viral load as that of a symptomatic case. Seven days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with from the chalet a positive endotracheal aspirate; all previous and concurrent nasopharyngeal specimens were negative. Additionally, 172 contacts were monitored; all contacts tested for SARS-CoV-2 (N = 73) were negative.ConclusionsThe occurrence in this cluster of 1 asymptomatic case with similar viral load as a symptomatic patient suggests transmission potential of asymptomatic individuals. The fact that an infected child did not transmit the disease despite close interactions within schools suggests potential different transmission dynamics in children. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspected cases of coronavirus disease 2019.

Published
2020
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26. Pseudomonas aeruginosa Implant-Associated Bone and Joint Infections: Experience in a Regional Reference Center in France

Author

Cerioli, Matteo, primary, Batailler, Cécile, additional, Conrad, Anne, additional, Roux, Sandrine, additional, Perpoint, Thomas, additional, Becker, Agathe, additional, Triffault-Fillit, Claire, additional, Lustig, Sebastien, additional, Fessy, Michel-Henri, additional, Laurent, Frederic, additional, Valour, Florent, additional, Chidiac, Christian, additional, and Ferry, Tristan, additional

Published
2020
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27. Type I IFN immunoprofiling in COVID-19 patients

Author

Trouillet-Assant, Sophie, primary, Viel, Sebastien, additional, Gaymard, Alexandre, additional, Pons, Sylvie, additional, Richard, Jean-Christophe, additional, Perret, Magali, additional, Villard, Marine, additional, Brengel-Pesce, Karen, additional, Lina, Bruno, additional, Mezidi, Mehdi, additional, Bitker, Laurent, additional, Belot, Alexandre, additional, Mouton, William, additional, Oriol, Guy, additional, Compagnon, Christelle, additional, Generenaz, Laurence, additional, Cheynet, Valérie, additional, Ader, Florence, additional, Becker, Agathe, additional, Benech, Nicholas, additional, Chauvelot, Pierre, additional, Chidiac, Christian, additional, Conrad, Anne, additional, Ferry, Tristan, additional, Miailhes, Patrick, additional, Perpoint, Thomas, additional, Perry, Marielle, additional, Pouderoux, Cécile, additional, Roux, Sandrine, additional, Triffault-Fillit, Claire, additional, Valour, Florent, additional, Hodane, Yonis, additional, Chauvelot, Louis, additional, Chabert, Paul, additional, Provoost, Judith, additional, David, Guillaume, additional, Folliet, Laure, additional, Lecam, Pierre, additional, Billaud, Geneviève, additional, Bouscambert, Maude, additional, Escuret, Vanessa, additional, Frobert, Emilie, additional, Bal, Antonin, additional, Destras, Grégory, additional, Josset, Laurence, additional, Morfin, Florence, additional, Munier, Clément, additional, Valette, Martine, additional, Venet, Fabienne, additional, Garnier, Lorna, additional, Pescarmona, Rémi, additional, Lombard, Christine, additional, and Walzer, Thierry, additional

Published
2020
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28. Sexually transmitted infections knowledge in different populations attending a French University Hospital - A prospective observational study.

Author

Alfaiate, Dulce, Giaché, Susanna, Pradat, Pierre, Cotte, Laurent, Chidiac, Christian, the Croix-Rousse STI Study Group, Ader, Florence, Adouard-Groslafeige, Carole, Becker, Agathe, Braun, Evelyne, Fernandez, Christine, Ferry, Tristan, Godinot, Matthieu, Lippman-Trotignon, Joanna, Pansu, Aymeric, Perpoint, Thomas, Roux, Sandrine, Schlienger, Isabelle, Triffault-Fillit, Claire, and Valour, Florent

Abstract

We conducted a prospective study about sexually transmitted infections (STIs) knowledge in different populations attending Lyon's University Hospitals in order to estimate awareness on STIs. Pre-exposure prophylaxis (PrEP)-users (PrEP group), persons living with HIV (PLWH group) and persons undergoing free STI screening (screening group) filled an anonymous questionnaire evaluating STI knowledge. A composite STI knowledge score was calculated and was correlated with patients' characteristics. A total of 756 patients were enrolled in three groups: screening (n = 509), PrEP (n = 103) and PLWH (n = 144). STI transmission knowledge was better for HIV than for other STIs. The median STI knowledge score was significantly higher in PrEP-users than in the screening and PLWH groups. PrEP use and a previous STI diagnosis were independently associated with a higher score. PrEP-users have better STI knowledge than PLWH and persons undergoing free STI screening. Sexual health promotion interventions routinely reserved to PrEP-users in France seem to be effective in raising the awareness of this group for STIs. Continuous efforts are justified for PLWH and the younger layers of the population. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Les paradoxes de l’héritage cartésien dans la philosophie et les sciences cognitives : John Searle, La redécouverte de l’esprit

Author

Roux, Sandrine

Subjects
HPCD, PHI013000, PHI005000, HPQ, PHI016000, Descartes, cartésianisme, HPJ, histoire de la philosophie
Abstract

Face à la récurrence des références à Descartes dans les travaux de philosophie de l’esprit contemporaine et à la fréquence de l’emploi du terme cartésien pour désigner des théories actuelles du mental, il est intéressant de s’interroger sur ce que signifie aujourd’hui être cartésien dans le domaine de la philosophie et des sciences cognitives. Il existe a priori différentes manières d’aborder cette question. Nous aurions pu, par exemple, dresser l’inventaire de ce qu’il reste du cartésianism...

Published
2018

31. L’Empreinte cartésienne

Author

Roux, Sandrine

Subjects
Histoire de la philosophie, Philosophie de l’esprit, Problème corps-esprit, Philosophie, Cartésianisme
Abstract

En abordant le problème corps-esprit sous l’angle des difficultés engendrées par le cartésianisme, cet ouvrage propose un parcours menant de Descartes à la philosophie de l’esprit contemporaine, ainsi qu’une évaluation des positions, sur la base des faits qu’elles permettent ou non d’expliquer., Addressing the mind-body problem in light of the difficulties raised by Cartesianism, this work traces a route leading from Descartes to contemporary philosophy of mind along with an evaluation of positions that focuses on certain facts and asks whether these positions do or do not make it possible to explain them.

Published
2018
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34. Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

Author

Roux, Sandrine, Valour, Florent, Karsenty, Judith, Gagnieu, Marie-Claude, Perpoint, Thomas, Lustig, Sebastien, Ader, Florence, Martha, Benoit, Laurent, Fréderic, Chidiac, Christian, Ferry, Tristan, Group, The Lyon Bji Study, Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Unité fonctionnelle de Pharmacologie Spécialisée, Hospices Civils de Lyon (HCL), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Pathogenèse des légionelles- Legionella pathogenesis (LegioPath), Maladies infectieuses, Centre Hospitalier Chalon-sur-Saône William Morey, Laboratoire de bactériologie, Centre national de référence staphlocoques, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Cadic, Ifsttar

Subjects
0301 basic medicine, Male, Joint Prosthesis, ARTICULATION HUMAINE, Salvage therapy, Kaplan-Meier Estimate, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Eosinophilic pneumonia, Medicine, 030212 general & internal medicine, Treatment Failure, Aged, 80 and over, OS, Middle Aged, Staphylococcal Infections, DAPTOMYCIN, 3. Good health, Anti-Bacterial Agents, Treatment Outcome, Infectious Diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Cohort study, medicine.drug, Research Article, Adult, medicine.medical_specialty, [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Prosthesis-Related Infections, Adolescent, 030106 microbiology, Drug Administration Schedule, 03 medical and health sciences, Cmin, Young Adult, BIOMECANIQUE, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Humans, Adverse effect, Aged, Proportional Hazards Models, Retrospective Studies, Salvage Therapy, business.industry, Retrospective cohort study, EOSINOPHILIC PNEUMONIA, medicine.disease, Surgery, Concomitant, Daptomycin, BONE AND JOINT INFECTION, business
Abstract

Background: Even if daptomycin does not have approval for the treatment of bone and joint infections (BJI), the Infectious Diseases Society of America guidelines propose this antibiotic as alternative therapy for prosthetic joint infection. The recommended dose is 6 mg/kg/d, whereas recent data support the use of higher doses in these patients.Methods: We performed a cohort study including consecutive patients that have received daptomycin >6 mg/kg/d for complex BJI between 2011 and 2013 in a French regional reference center. Factors associated with treatment failure were determined on univariate Cox analysis and Kaplan-Meier curves.Results: Forty-three patients (age, 61 ± 17 years) received a mean dose of 8 ± 0.9 mg/kg/d daptomycin, for a mean 81 ± 59 days (range, 6-303 days). Most had chronic (n = 37, 86 %) implant-associated (n = 37, 86 %) BJI caused by coagulasenegative staphylococci (n = 32, 74 %). A severe adverse event (SAE) occurred in 6 patients (14 %), including 2 cases of eosinophilic pneumonia, concomitant with daptomycin Cmin >24 mg/L. Outcome was favorable in 30 (77 %) of the 39 clinically assessable patients. Predictors for treatment failure were age, non-optimal surgery and daptomycin withdrawal for SAE.Conclusions: Prolonged high-dose daptomycin therapy was effective in patients with complex BJI. However, optimal surgery remains the cornerstone of medico-surgical strategy; and a higher incidence of eosinophilic pneumonia than expected was recorded.

Published
2016
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35. Transforming Growth Factor Beta 1 Modulates the Functional Expression of the Neurokinin-1 Receptor in Human Keratocytes

Author

Roux, Sandrine Le, Borbely, Gabor, Słoniecka, Marta, Backman, Ludvig J, and Danielson, Patrik

Subjects
Adult, Male, Medicinska och farmaceutiska grundvetenskaper, substance P, Blotting, Western, Corneal Keratocytes, Real-Time Polymerase Chain Reaction, Article, Transforming Growth Factor beta1, Cornea, stroma, Humans, Cells, Cultured, Aged, Cell Proliferation, Aged, 80 and over, neuropeptides, Cell Differentiation, Basic Medicine, Middle Aged, Receptors, Neurokinin-1, Immunohistochemistry, cytokines, Gene Expression Regulation, RNA, Female, Signal Transduction
Abstract

Purpose: Transforming growth factor beta 1 (TGF-β1) is a cytokine involved in a variety of processes, such as differentiation of fibroblasts into myofibroblasts. TGF-β1 has also been shown to delay the internalization of the neurokinin-1 receptor (NK-1 R) after its activation by its ligand, the neuropeptide substance P (SP). NK-1 R comprises two naturally occurring variants, a full-length and a truncated form, triggering different cellular responses. SP has been shown to affect important events in the cornea – such as stimulating epithelial cell proliferation – processes that are involved in corneal wound healing and thus in maintaining the transparency of the corneal stroma. An impaired signaling through NK-1 R could thus impact the visual quality. We hypothesize that TGF-β1 modulates the expression pattern of NK-1 R in human corneal stroma cells, keratocytes. The purpose of this study was to test that hypothesis. Methods: Cultures of primary keratocytes were set up with cells derived from healthy human corneas, obtained from donated transplantation graft leftovers, and characterized by immunocytochemistry and Western blot. Immunocytochemistry for TGF-β receptors and NK-1 R was performed. Gene expression was assessed with real-time polymerase chain reaction (qPCR). Results: Expression of TGF-β receptors was confirmed in keratocytes in vitro. Treating the cells with TGF-β1 significantly reduced the gene expression of NK-1 R. Furthermore, immunocytochemistry for NK-1 R demonstrated that it is specifically the expression of the full-length isotype of the receptor that is reduced after treatment with TGF-β1, which was also confirmed with qPCR using a specific probe for the full-length receptor. Conclusions: TGF-β1 down-regulates the gene expression of the full-length variant of NK-1 R in human keratocytes, which might impact its signaling pathway and thus explain the known delay in internalization after activation by SP seen with TGF-β1 treatment.

Published
2016

38. Genetic polymorphisms of ABCB1 (P-glycoprotein) as a covariate influencing daptomycin pharmacokinetics: a population analysis in patients with bone and joint infection.

Author

Bricca, Romain, Goutelle, Sylvain, Roux, Sandrine, Gagnieu, Marie-Claude, Becker, Agathe, Conrad, Anne, Valour, Florent, Laurent, Frederic, Triffault-Fillit, Claire, Chidiac, Christian, Ferry, Tristan, and Lyon Bone and Joint Infection Study Group

Subjects
GENETIC polymorphisms, PHARMACOKINETICS, LIPOPEPTIDE antibiotics, METHICILLIN-resistant staphylococcus aureus, MEDICAL care
Abstract

Background: Daptomycin has been recognized as a therapeutic option for the treatment of bone and joint infection (BJI). Gene polymorphism of ABCB1, the gene encoding P-glycoprotein (P-gp), may influence daptomycin pharmacokinetics (PK).Objectives: We aimed to examine population PK of daptomycin and its determinants, including genetic factors, in patients with BJI.Patients and Methods: We analysed data from patients who received daptomycin for BJI between 2012 and 2016 in our regional reference centre and who had measured daptomycin concentrations and P-gp genotyping. A population approach was used to analyse PK data. In covariate analysis, we examined the influence of three single nucleotide variations (SNVs) of ABCB1 (3435C > T, 2677G > T/A and 1236C > T) and that of the corresponding haplotype on daptomycin PK parameters. Simulations performed with the final model examined the influence of covariates on the probability to achieve pharmacodynamic (PD) targets.Results: Data from 81 patients were analysed. Daptomycin body CL (CLDAP) correlated with CLCR and was 23% greater in males than in females. Daptomycin central V (V1) was allometrically scaled to body weight and was 25% lower in patients with homozygous CGC ABCB1 haplotype than in patients with any other genotype. Simulations performed with the model showed that sex and P-gp haplotype may influence the PTA for high MIC values and that a dosage of 10 mg/kg/24 h would optimize efficacy.Conclusions: Daptomycin dosages higher than currently recommended should be evaluated in patients with BJI. Gender and P-gp gene polymorphism should be further examined as determinants of dosage requirements. [ABSTRACT FROM AUTHOR]

Published
2019
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39. Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

Author

Spang, Christoph, Backman, Ludvig J., Le Roux, Sandrine, Chen, Jialin, Danielson, Patrik, Spang, Christoph, Backman, Ludvig J., Le Roux, Sandrine, Chen, Jialin, and Danielson, Patrik

Abstract

Background: A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and the impact of loading and exposure to glucocorticoids on the glutamate signaling machinery. Methods: Plantaris tendon tissue and cultured plantaris tendon derived cells were immunohisto-/cytochemically stained for glutamate, N-Methyl-D-Aspartate receptor 1 (NMDAR1) and vesicular glutamate transporter 2 (VGluT2). Primary cells were exposed to glutamate or receptor agonist NMDA. Cell death/viability was measured via LDH/MTS assays, and Western blot for cleaved caspase 3 (c-caspase 3) and cleaved poly (ADP-ribose) polymerase (c-PARP). Scleraxis mRNA (Scx)/protein(SCX) were analyzed by qPCR and Western blot, respectively. A FlexCell system was used to apply cyclic strain. The effect of glucocorticoids was studies by adding dexamethasone (Dex). The mRNA of the glutamate synthesizing enzymes Got1 and Gls, and NMDAR1 protein were measured. Levels of free glutamate were determined by a colorimetric assay. Results: Immunoreactions for glutamate, VGluT2, and NMDAR1 were found in tenocytes and peritendinous cells in tissue sections and in cultured cells. Cell death was induced by high concentrations of glutamate but not by NMDA. Scleraxis mRNA/protein was down-regulated in response to NMDA/glutamate stimulation. Cyclic strain increased, and Dex decreased, Gls and Got1 mRNA expression. Free glutamate levels were lower after Dex exposure. Conclusions: In conclusion, NMDA receptor stimulation leads to a reduction of scleraxis expression that may be involved in a change of phenotype in tendon cells. Glutamate synthesis is increased in tendon cells in response to strain and decreased by glucocorticoid stimulation. This implies that locally produced glutamate could be involved in the tissue changes observed in tendinopathy.

Published
2017
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40. Substance P Enhances Keratocyte Migration and Neutrophil Recruitment through Interleukin-8

Author

Sloniecka, Marta, Le Roux, Sandrine, Zhou, Qingjun, Danielson, Patrik, Sloniecka, Marta, Le Roux, Sandrine, Zhou, Qingjun, and Danielson, Patrik

Abstract

Keratocytes, the resident cells of the corneal stroma, are responsible for maintaining turnover of this tissue by synthesizing extracellular matrix components. When the cornea is injured, the keratocytes migrate to the wounded site and participate in the stromal wound healing. The neuropeptide substance P (SP), which is also known to be produced by non-neuronal cells, has previously been implicated in epithelial wound healing after corneal injury. Corneal scarring, which occurs in the stroma when the process of wound healing has malfunctioned, is one of the major causes of preventable blindness. This study aimed to elucidate the potential role of SP in keratocyte migration and therefore in stromal wound healing. We report that the expression and secretion of SP in human keratocytes are increased in response to injury in vitro. Moreover, SP enhances the migration of keratocytes by inducing the actin cytoskeleton reorganization and focal adhesion formation through the activation of the phosphatidylinositide 3-kinase and Ras-related C3 botulinum toxin substrate 1/Ras homolog gene family, member A pathway. Furthermore, SP stimulation leads to upregulated expression of the proinflammatory and chemotactic cytokine interleukin-8 (IL-8), which also contributes significantly to SP-enhanced keratocyte migration and is able to attract neutrophils. In addition, the preferred SP receptor, the neurokinin-1 receptor, is necessary to induce keratocyte migration and IL-8 secretion. In conclusion, we describe new mechanisms by which SP enhances migration of keratocytes and recruits neutrophils, two necessary steps in the corneal wound-healing process, which are also likely to occur in other tissue injuries.

Published
2016
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42. HHV-6 infection after allogeneic hematopoietic stem cell transplantation: From chromosomal integration to viral co-infections and T-cell reconstitution patterns

Author

Quintela, Adrien, primary, Escuret, Vanessa, additional, Roux, Sandrine, additional, Bonnafous, Pascale, additional, Gilis, Lila, additional, Barraco, Fiorenza, additional, Labussière-Wallet, Hélène, additional, Duscastelle-Leprêtre, Sophie, additional, Nicolini, Franck-Emmanuel, additional, Thomas, Xavier, additional, Chidiac, Christian, additional, Ferry, Tristan, additional, Frobert, Emilie, additional, Morisset, Stéphane, additional, Poitevin-Later, Françoise, additional, Monneret, Guillaume, additional, Michallet, Mauricette, additional, Ader, Florence, additional, Ader, F., additional, Bachy, E., additional, Balsat, M., additional, Barraco, F., additional, Bienvenu, A.L., additional, Billaud, G., additional, Biron, F., additional, Boibieux, A., additional, Chidiac, C., additional, Conrad, A., additional, Ducastelle-Leprêtre, S., additional, Dumitrescu, O., additional, Dupont, D., additional, Escuret, V., additional, Ferry, T., additional, Frobert, E., additional, Gilis, L., additional, Grateau, A., additional, Heiblig, M., additional, Labussière-Wallet, H., additional, Le Maréchal, M., additional, Lebras, L., additional, Lina, B., additional, Lina, G., additional, Quintela, A., additional, Miailhes, P., additional, Michallet, A.-S., additional, Michallet, M., additional, Michallet, M.-C., additional, Monneret, G., additional, Morfin-Sherpa, F., additional, Nicolini, F.E., additional, Perpoint, T., additional, Peyrouse de Montclos, M., additional, Picot, S., additional, Poitevin-Later, F., additional, Ranc, A.G., additional, Roux, S., additional, Salles, G., additional, Saison, J., additional, Sénéchal, A., additional, Sobh, M., additional, Thomas, X., additional, Valour, F., additional, and Wattel, E., additional

Published
2016
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43. Qu'est-ce qu'être cartésien ?

Author

Angaut, Jean-Christophe, Azouvi, François, Bloch, Olivier, Bontems, Vincent, Bos, Erik-Jan, Bouchilloux, Hélène, Capdevila, Nestor, Carvallo, Sarah, Cassan, Élodie, de Calan, Ronan, de Casabianca, Denis, Feneuil, Anthony, Gengoux, Nicole, Giocanti, Sylvia, Girard, Pierre, Gros, Jean-Michel, Henry, Julie, Husser, Anne-Claire, Kambouchner, Denis, Kolesnik-Antoine, Delphine, Lærke, Mogens, Lagrée, Jacqueline, Lamouche, Fabien, Méchoulan, Éric, Moreau, Pierre-François, Nachtomy, Ohad, Ottaviani, Didier, Pellegrin, Marie-Frédérique, Pépin, François, Prete, Antonella Del, Roux, Sandrine, Roux, Sophie, Scribano, Emanuela, Volpilhac, Aude, CERPHI, Institut d'Histoire de la Pensée Classique (IHPC), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)-Institut d’Histoire des Représentations et des Idées dans les Modernités (IHRIM), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d’Histoire des Représentations et des Idées dans les Modernités (IHRIM), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Jean Monnet - Saint-Étienne (UJM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Jean Moulin - Lyon 3 (UJML), and Kolesnik-Antoine, Delphine

Subjects
HPCD, History & Philosophy Of Science, PHI013000, HPQ, PHI016000, Esprit et corps, Histoire des idées, 05 social sciences, 06 humanities and the arts, 050905 science studies, histoire de la philosophie, [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, René Descartes, 060105 history of science, technology & medicine, PHI005000, Descartes, philosophie, cartésianisme, 0601 history and archaeology, 0509 other social sciences, HPJ, Cartésianisme
Abstract

Coll. "La croisée des chemins"; 4e de couverture : "Qu'est-ce qui fait la spécificité du cartésianisme dans l'histoire des idées ? Ce volume propose une réponse à cette question : le cartésianisme peut tout aussi bien se penser à l'aide des outils d'une histoire de la philosophie classique recourant à la philologie, aux " sources " et à l'intertextualité, y compris en des termes critiques ; que dans les lexiques de la réfraction, de la transformation voire de la construction, rationnelle ou imaginaire. Dans ce dernier cas, on peut parfaitement revendiquer la neutralisation des exigences de continuité attestables entre l'invention et la source originelle et tenter de penser des Descartes ad hoc, étant entendu qu'une telle entreprise aura toujours, en retour, quelque chose à nous apprendre sur le corpus d'origine. De Descartes à la période contemporaine, les contributions présentées offrent une synthèse inédite du prisme de ces lectures possibles, toute appelées, tendanciellement mais différemment, par l'œuvre de Descartes."

Published
2013
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44. Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ

Author

Sloniecka, Marta, Le Roux, Sandrine, Boman, Peter, Byström, Berit, Zhou, Qingjun, Danielson, Patrik, Sloniecka, Marta, Le Roux, Sandrine, Boman, Peter, Byström, Berit, Zhou, Qingjun, and Danielson, Patrik

Abstract

Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal cells and to be involved in many cellular processes. The aim of this study was to assess the endogenous intracellular and secreted levels of the neuropeptides substance P (SP) and neurokinin A (NKA), and of the neurotransmitters acetylcholine (ACh), catecholamines (adrenaline, noradrenaline and dopamine), and glutamate, as well as the expression profiles of their receptors, in human primary keratocytes in vitro and in keratocytes of human corneal tissue sections in situ. Cultured keratocytes expressed genes encoding for SP and NKA, and for catecholamine and glutamate synthesizing enzymes, as well as genes for neuropeptide, adrenergic and ACh (muscarinic) receptors. Keratocytes in culture produced SP, NKA, catecholamines, ACh, and glutamate, and expressed neurokinin-1 and -2 receptors (NK-1R and NK-2R), dopamine receptor D-2, muscarinic ACh receptors, and NDMAR1 glutamate receptor. Human corneal sections expressed SP, NKA, NK-1R, NK-2R, receptor D2, choline acetyl transferase (ChAT), M-3, M4 and M-5 muscarinic ACh receptors, glutamate, and NMDAR1, but not catecholamine synthesizing enzyme or the alpha(1) and beta(2) adrenoreceptors, nor M1 receptor. In addition, expression profiles assumed significant differences between keratocytes from the peripheral cornea as compared to those from the central cornea, as well as differences between keratocytes cultured under various serum concentrations. In conclusion, human keratocytes express an array of neuropeptides and neurotransmitters. The cells furthermore express receptors for neuropeptides/neurotransmitters, which suggests that they are susceptible to stimulation by these substances in the cornea, whether of neuronal or non-neuronal origin. As it has been shown that neuropep

Published
2015
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