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2. Antenatal depressed mood and child cognitive and physical growth at 18-months in South Africa: a cluster randomised controlled trial of home visiting by community health workers

Author

Tomlinson, M, Rotheram-Borus, MJ, Scheffler, A, and le Roux, I

Subjects
Midwifery, Public Health, Health Sciences, Behavioral and Social Science, Mental Health, Depression, Prevention, Clinical Trials and Supportive Activities, Pediatric, Clinical Research, Reproductive health and childbirth, Mental health, Good Health and Well Being, Zero Hunger, Adult, Child, Child Development, Child Health, Cognition, Community Health Workers, Counseling, Female, House Calls, Humans, Maternal Health, Mother-Child Relations, Mothers, Outcome Assessment, Health Care, Postpartum Period, Pregnancy, Pregnancy Complications, Prenatal Care, Prenatal Exposure Delayed Effects, Antenatal depression, cognitive development, community health workers, home visiting, infants, low and middle income countries, maternal and child health, Epidemiology, Health services and systems, Social and personality psychology
Abstract

AimTo examine the child outcomes at 18-months post-birth of a population cohort of women with antenatal depressed mood, half of whom were randomly chosen to receive perinatal home visits from community health workers during pregnancy.MethodPregnant women in 24 neighbourhoods (98% participation) were randomised by neighbourhood to: (1) standard clinic care (SC; 12 neighbourhoods; n = 594) or (2) the Philani Intervention Program, a home visiting intervention plus standard care (12 neighbourhoods; n = 644). The physical and cognitive outcomes of children of mothers with antenatally depressed mood (Edinburg Perinatal Depression Scale >13) in the intervention condition were compared at 18-months post-birth to children of mothers without depressed mood in pregnancy in both conditions.ResultsMore than a third of mothers had heightened levels of antenatal depressed mood (35%), similar across conditions. Antenatal depressed mood was significantly associated with being a mother living with HIV, using alcohol and food insecurity. At 18-months, the overall cognitive and motor scale scores on the Bayley Scales of Development were similar. However, 10.3% fewer children of mothers with antenatal depressed mood in the intervention condition had cognitive scores on the Bayley Scales that were less than 85 (i.e., s.d. = 2 lower than normal) compared with children of mothers with antenatal depressed mood in the SC condition. Intervention children of mothers with antenatal depressed mood were also significantly less likely to be undernourished (Weight-for-Age Z-scores < -2).ConclusionCognitive development and child growth among children born to mothers with antenatal depressed mood can be improved by mentor mother home visitors, probably resulting from better parenting and care received early in life.

Published
2018

12. Proposed vitamin A supplementation programme for South Africa - design, coverage and cost

Author

Saitowitz, R, Hendricks, M, Fiedler, J, le Roux, I, Hussey, G, and Makan, B

Abstract

Background. A national survey of the micronutrient status of preschool children in South Africa established that vitamin A deficiency is a significant public health problem, requiring urgent attention. A number of immediate and long-term intenrentions were recommended, including the introduction of a vitamin A supplementation programme and a food fortification programme.Objectives. The aim of the study was to assist in the development and implementation of a national vitamin A supplementation programme at primary health care facilities for mothers and children. This was achieved by determining the design, coverage and cost of a national primary health care facility vitamin A supplementation programme.Methods. Based on an extensive review of the literature, the main components of a primary health care facility vitamin A supplementation programme were identified. The annual, recurrent cost of each of the programme component wer estimated for the nine provinces in South Africa. Immunisation coverage rates were used as a proxy for estimating the coverage of the programme.Results. The main components of the programme were identified as: promotion, training, purchase of vitamin A capsules, distribution of vitamin A capsules to primary health care facilities, clistribution of cap ule to the programme beneficiaries, and monitoring and evaluation. The programme would operate from primary health care facililities and would target all children between 6 and 24 months of age and newly delivered mothers. It was estimated that the programme would cover 74% of children and 95% of postpartum women nationally. The total annual, recurrent cost of the national programme was estimated at R16.4 million. The bulk of the costs would include personnel costs, comprising 68% of the total costs. Other costs included promotion (27%), vitamin A capsules (4%) and training (1%). The cost of the programme would vary significantly by province, but the provinces' average total cost per beneficiary would be similar.Conclusion. A primary health care facility vitamin A supplementation programme has been designed and accompanied by an estimated overall cost and coverage for implementation. The findings of the study showed that the programme would be financially feasible and would reach the majority of children under 24 months of age. It is recommended that further research be undertaken to extend the programme to the more 'hard to reach' population using other stategies such as mass immunisation campaigns.

Published
2016

14. GENE-54. A NOVEL MUTATION IN PRKCA IS THE MAJOR DRIVER OF CHORDOID GLIOMAS

Author

Marine Giry, Franck Bielle, Marie-Hélène Aubriot-Lorton, M. Sanson, Marc Polivka, Emmanuelle Huillard, Michel Kalamarides, Karima Mokhtari, Mailys Daniau, Shai Rosenberg, Maite Verreault, Stefano Maria Pagnotta, Antonio Iavarone, Aravindan Arun Nadaradjane, Anna Lasorella, Chiara Villa, Branger D, Iva Simeonova, Roux I, Sophie Paris, Y. Marie, Gleize, Alexandre Vasiljevic, and Emmanuèle Lechapt-Zalcman

Subjects
Abstracts, Cancer Research, Text mining, Oncology, business.industry, Neurology (clinical), Computational biology, Biology, business, Novel mutation, Gene
Published
2017

17. Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy

Author

Burgess, L. J., Maritz, F. J., Le Roux, I., and Taljaard, J. J.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, enzymes and coenzymes (carbohydrates), immune system diseases, nutritional and metabolic diseases, hemic and immune systems, Research Article
Abstract

BACKGROUND--A statistical audit of adenosine deaminase (ADA) in pleural effusions was undertaken. METHODS--ADA analysis, cytological and microbiological examinations, and differential cell counts were performed on 462 pleural fluid samples. RESULTS--ADA activity in tuberculous effusions was higher than in any other diagnostic group. At a level of 50 U/l the sensitivity and specificity for the identification of tuberculosis was 90% and 89%, respectively. CONCLUSIONS--ADA activity remains a useful test in the evaluation of pleural effusions.

Published
1995

20. Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis

Author

Reisinger, E., primary, Bresee, C., additional, Neef, J., additional, Nair, R., additional, Reuter, K., additional, Bulankina, A., additional, Nouvian, R., additional, Koch, M., additional, Buckers, J., additional, Kastrup, L., additional, Roux, I., additional, Petit, C., additional, Hell, S. W., additional, Brose, N., additional, Rhee, J.-S., additional, Kugler, S., additional, Brigande, J. V., additional, and Moser, T., additional

Published
2011
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24. Posters * Reproductive Endocrinology (i.e. PCOS, Menarche, Menopause etc.)

Author

Fujii, R., primary, Fujita, S., additional, Waseda, T., additional, Oka, Y., additional, Takagi, H., additional, Tomizawa, H., additional, Sasagawa, T., additional, Makinoda, S., additional, Cavagna, M., additional, Braga, D. P. A. F., additional, Figueira, R. C. S., additional, Aoki, T., additional, Maldonado, L. G. L., additional, Iaconelli, A., additional, Borges, E., additional, Prabhakar, s., additional, Dittrich, R., additional, Beckmann, M. W., additional, Hoffmann, I., additional, Mueller, A., additional, Kjotrod, S., additional, Carlsen, S. M., additional, Rasmussen, P. E., additional, Holst-Larsen, T., additional, Mellembakken, J., additional, Thurin-Kjellberg, A., additional, Haapaniemi Kouru, K., additional, Morin Papunen, L., additional, Humaidan, P., additional, Sunde, A., additional, von During, V., additional, Pappalardo, S., additional, Valeri, C., additional, Crescenzi, F., additional, Manna, C., additional, Sallam, H. N., additional, Polec, A., additional, Raki, M., additional, Tanbo, T., additional, Abyholm, T., additional, Fedorcsak, P., additional, Tabanelli, C., additional, Ferraretti, A. P., additional, Feliciani, E., additional, Magli, M. C., additional, Fasolino, C., additional, Gianaroli, L., additional, Wang, T., additional, Feng, C., additional, Song, Y., additional, Dong, M. Y., additional, Sheng, J. Z., additional, Huang, H. F., additional, Sayyah Melli, M., additional, Kazemi-shishvan, M., additional, Snajderova, M., additional, Zemkova, D., additional, Pechova, M., additional, Teslik, L., additional, Lanska, V., additional, Ketel, I., additional, Serne, E., additional, Stehouwer, C., additional, Korsen, T., additional, Hompes, P., additional, Smulders, Y., additional, Voorstemans, L., additional, Homburg, R., additional, Lambalk, C., additional, Bellver, J., additional, Martinez-Conejero, J. A., additional, Pellicer, A., additional, Labarta, E., additional, Alama, P., additional, Melo, M. A. B., additional, Horcajadas, J. A., additional, Agirregoitia, N., additional, Peralta, L., additional, Mendoza, R., additional, Exposito, A., additional, Matorras, R., additional, Agirregoitia, E., additional, Ajina, M., additional, Chaouache, N., additional, Gaddas, M., additional, Souissi, A., additional, Tabka, Z., additional, Saad, A., additional, Zaouali-Ajina, M., additional, Zbidi, A., additional, Eguchi, N., additional, Jinno, M., additional, Watanabe, A., additional, Hirohama, J., additional, Hatakeyama, N., additional, Choi, Y. M., additional, Kim, J. J., additional, Kim, D. H., additional, Yoon, S. H., additional, Ku, S. Y., additional, Kim, S. H., additional, Kim, J. G., additional, Lee, K. S., additional, Moon, S. Y., additional, Xiong, Y., additional, Liang, X., additional, Li, Y., additional, Yang, X., additional, Wei, L., additional, Fujii, R., additional, Utsunomiya, T., additional, Chu, S., additional, Li, P., additional, Akarsu, S., additional, Dirican, E. K., additional, Akin, K. O., additional, Kormaz, C., additional, Goktolga, U., additional, Ceyhan, S. T., additional, Kara, C., additional, Nadamoto, K., additional, Tarui, S., additional, Ida, M., additional, Sugihara, K., additional, Haruki, A., additional, Hukuda, A., additional, Morimoto, Y., additional, Albu, A., additional, Albu, D., additional, Sandu, L., additional, Kong, G., additional, Cheung, L., additional, Lok, I., additional, Pinto, A., additional, Teixeira, L., additional, Figueiredo, H., additional, Pires, I., additional, Silva Carvalho, J. L., additional, Pereira, M. L., additional, Faut, M., additional, de Zuniga, I., additional, Colaci, D., additional, Barrios, E., additional, Oubina, A., additional, Terrado Gil, G., additional, Motta, A., additional, Horton, M., additional, Sobral, F., additional, Gomez Pena, M., additional, Gleicher, N., additional, Barad, D. H., additional, Li, Y. P., additional, Zhao, H. C., additional, Spaczynski, R. Z., additional, Guzik, P., additional, Banaszewska, B., additional, Krauze, T., additional, Wykretowicz, A., additional, Wysocki, H., additional, Pawelczyk, L., additional, Sarikaya, E., additional, Gulerman, C., additional, Cicek, N., additional, Mollamahmutoglu, L., additional, Venetis, C. A., additional, Kolibianakis, E. M., additional, Toulis, K., additional, Goulis, D., additional, Loutradi, K., additional, Chatzimeletiou, K., additional, Papadimas, I., additional, Bontis, I., additional, Tarlatzis, B. C., additional, Schultze-Mosgau, A., additional, Griesinger, G., additional, Schoepper, B., additional, Cordes, T., additional, Diedrich, K., additional, Al-Hasani, S., additional, Gomez, R., additional, Jovanovic, V., additional, Sauer, C. M., additional, Shawber, C. J., additional, Sauer, M. V., additional, Kitajewski, J., additional, Zimmermann, R. C., additional, Bungum, L., additional, Jacobsson, A. K., additional, Rosen, F., additional, Becker, C., additional, Andersen, C. Y., additional, Guner, N., additional, Giwercman, A., additional, Kiapekou, E., additional, Zapanti, E., additional, Boukelatou, D., additional, Mavreli, T., additional, Bletsa, R., additional, Stefanidis, K., additional, Drakakis, P., additional, Mastorakos, G., additional, Loutradis, D., additional, Malhotra, N., additional, Sharma, V., additional, Kumar, S., additional, Roy, K. K., additional, Sharma, J. B., additional, Ferraretti, A., additional, Crippa, A., additional, Stanghellini, I., additional, Robles, F., additional, Serdynska-Szuster, M., additional, Kristensen, S. L., additional, Ernst, E., additional, Toft, G., additional, Olsen, S. F., additional, Bonde, J. P., additional, Vested, A., additional, Ramlau-Hansen, C. H., additional, Wang, F. F., additional, Qu, F., additional, Ding, G. L., additional, Gallot, V., additional, Genro, V., additional, Roux, I., additional, Scheffer, J. B., additional, Frydman, R., additional, Fanchin, R., additional, Kanta Goswami, S., additional, Banerjee, S., additional, Chakravarty, B. N., additional, Kabir, S. N., additional, Seeber, B. E., additional, Morandell, E., additional, Kurzthaler, D., additional, Wildt, L., additional, Dieplinger, H., additional, Tutuncu, L., additional, Bodur, S., additional, Dundar, O., additional, Ron - El, R., additional, Seger, R., additional, Komarovsky, D., additional, Kasterstein, E., additional, Komsky, A., additional, Maslansky, B., additional, Strassburger, D., additional, Ben-Ami, I., additional, Zhao, X. M., additional, Ni, R. M., additional, Lin, L., additional, Dong, M., additional, Tu, C. H., additional, He, Z. H., additional, Yang, D. Z., additional, Karamalegos, C., additional, Polidoropoulos, N., additional, Papanikopoulos, C., additional, Stefanis, P., additional, Argyrou, M., additional, Doriza, S., additional, Sisi, V., additional, Moschopoulou, M., additional, Karagianni, T., additional, Mentorou, C., additional, Economou, K., additional, Davies, S., additional, Mastrominas, M., additional, Gougeon, A., additional, De Los Santos, M. J., additional, Garcia-Laez, V., additional, Esteban, F., additional, Crespo, J., additional, Li, H. W. R., additional, Anderson, R. A., additional, Yeung, W. S. B., additional, Ho, P. C., additional, Ng, E. H. Y., additional, Yang, H. I., additional, Lee, K. E., additional, Seo, S. K., additional, Kim, H. Y., additional, Cho, S. H., additional, Choi, Y. S., additional, Lee, B. S., additional, Park, K. H., additional, Cho, D. J., additional, Hart, R., additional, Doherty, D., additional, Mori, T., additional, Hickey, M., additional, Sloboda, D., additional, Norman, R., additional, Huang, R. C., additional, Beilin, L., additional, Freiesleben, N., additional, Lossl, K., additional, Johannsen, T. H., additional, Loft, A., additional, Bangsboll, S., additional, Hougaard, D., additional, Friis-Hansen, L., additional, Christiansen, M., additional, Nyboe Andersen, A., additional, Thum, M. Y., additional, Abdalla, H., additional, Martinez-Salazar, J., additional, De la Fuente, G., additional, Kohls, G., additional, Garcia Velasco, J. A., additional, Yasmin, E., additional, Kukreja, S., additional, Barth, J., additional, Balen, A. H., additional, Esra, T., additional, Var, T., additional, Citil, A., additional, Dogan, M., additional, Messini, C. I., additional, Dafopoulos, K., additional, Chalvatzas, N., additional, Georgoulias, P., additional, Anifandis, G., additional, Messinis, I. E., additional, Celik, O., additional, Hascalik, S., additional, Celik, N., additional, Sahin, I., additional, Aydin, S., additional, Hanna, C. W., additional, Bretherick, K. L., additional, Liu, C. C., additional, Stephenson, M. D., additional, Robinson, W. P., additional, Louwers, Y. V., additional, Goodarzi, M. O., additional, Taylor, K. D., additional, Jones, M. R., additional, Cui, J., additional, Kwon, S., additional, Chen, Y. D. I., additional, Guo, X., additional, Stolk, L., additional, Uitterlinden, A. G., additional, Laven, J. S. E., additional, Azziz, R., additional, Navaratnarajah, R., additional, Grun, B., additional, Sinclair, J., additional, Dafou, D., additional, Gayther, S., additional, Timms, J. F., additional, Hardiman, P. J., additional, Ye, Y., additional, Wu, R., additional, Ou, J., additional, Kim, S. D., additional, Jee, B. C., additional, Lee, J. Y., additional, Suh, C. S., additional, Jung, J. H., additional, Opmeer, B. C., additional, Broeze, K. A., additional, Coppus, S. F., additional, Collins, J. A., additional, Den Hartog, J. E., additional, Land, J. A., additional, Van der Linden, P. J., additional, Marianowski, P., additional, Ng, E., additional, Van der Steeg, J. W., additional, Steures, P., additional, Strandell, A., additional, Mol, B. W., additional, Tarlatzi, T. B., additional, Kyrou, D., additional, Mertzanidou, A., additional, Fatemi, H. M., additional, Devroey, P., additional, Batenburg, T. E., additional, Konig, T. E., additional, Overbeek, A., additional, Schats, R., additional, Lambalk, C. B., additional, Carone, D., additional, Vizziello, G., additional, Vitti, A., additional, Chiappetta, R., additional, Topcu, H. O., additional, Yuksel, B., additional, Islimye, M., additional, Karakaya, J., additional, ozat, M., additional, Batioglu, S., additional, Kuchenbecker, W. K., additional, Groen, H., additional, Bolster, J. H., additional, van Asselt, S., additional, Wolffenbuettel, B. H., additional, Hoek, A., additional, Wu, Y., additional, Pan, H., additional, Chen, X., additional, Huang, H., additional, Zavos, A., additional, Verikouki, C., additional, Van Os, L., additional, Vink-Ranti, C. Q. J., additional, Rijnders, P. M., additional, Tucker, K. E., additional, Jansen, C. A. M., additional, Lucco, F., additional, Pozzobon, C., additional, Lara, E., additional, Galliano, D., additional, Ballesteros, A., additional, Ghoshdastidar, B., additional, Maity, S. P., additional, Ghoshdastidar, S., additional, Luna, M., additional, Vela, G., additional, Sandler, B., additional, Barritt, J., additional, Flisser, E. D., additional, Copperman, A. B., additional, Nogueira, D., additional, Prat, L., additional, Degoy, J., additional, Bonald, F., additional, Montagut, J., additional, Maity, S., additional, Chen, S., additional, Luo, C., additional, Zhen, H., additional, Shi, X., additional, Wu, F., additional, Ni, Y., additional, Merdassi, G., additional, Chaker, A., additional, Kacem, K., additional, Benmeftah, M., additional, Fourati, S., additional, Wahabi, D., additional, Zhioua, F., additional, Zhioua, A., additional, Saini, P., additional, Saini, A., additional, Sugiyama, R., additional, Nakagawa, K., additional, Nishi, Y., additional, Jyuen, H., additional, Kuribayashi, Y., additional, Inoue, M., additional, Jancar, N., additional, Vrtacnik Bokal, E., additional, Virant-Klun, I., additional, Lee, J. H., additional, Kim, S. G., additional, Cha, E. M., additional, Park, I. H., additional, Lee, K. H., additional, Dahdouh, E. M., additional, Desrosiers, P., additional, St-Michel, P., additional, Villeneuve, M., additional, Fontaine, J. Y., additional, Granger, L., additional, Ramon, O., additional, Burgos, J., additional, Abanto, E., additional, Gonzalez, M., additional, Mugica, J., additional, Corcostegui, B., additional, Tal, J., additional, Ziskind, G., additional, Ohel, G., additional, Paltieli, Y., additional, Paz, G., additional, Lewit, N., additional, Sendel, H., additional, Khouri, S., additional, Calderon, I., additional, van Gelder, P., additional, Al-Inany, H. G., additional, Antaki, R., additional, Dean, N., additional, Lapensee, L., additional, Racicot, M., additional, Menard, S., additional, Kadoch, I., additional, Meylaerts, L. J., additional, Dreesen, L., additional, Vandersteen, M., additional, Neumann, C., additional, Zollner, U., additional, Kato, K., additional, Segawa, T., additional, Kawachiya, S., additional, Okuno, T., additional, Kobayashi, T., additional, Takehara, Y., additional, Kato, O., additional, Jayaprakasan, K., additional, Nardo, L., additional, Hopkisson, J., additional, Campbell, B., additional, and Raine-Fenning, N., additional

Published
2010
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38. Prevalence of CFTR mutations in hypertrypsinaemia detected through neonatal screening for cystic fibrosis.

Author

Scotet, V., de Braekeleer, M., Audrezet, M.-P., Lod é, L., Verlingue, C., Qu é r é, I., Mercier, B., Dugu é p é roux, I., Codet, J.-P., Moineau, M.-P., Parent, P., and F é rec, C.

Subjects
CYSTIC fibrosis in children, GENETIC mutation, JUVENILE diseases
Abstract

Presents information on a study which assessed the heterozygosity frequency among children with hypertrypsinaemia detected through the cystic fibrosis (CF) screening program implemented in France. Protocols used for screening CF in the children; Classification of mutations detected in the CF transmembrane conductance regulator gene; Results.

Published
2001
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41. Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4<SUP>+</SUP> T cells

Author

Owen, M.J., Ish-Horowicz, D., Roux, I. Le, Dunne, J., Dallman, M.J., Hoyne, G.F., Corsin-Jimenez, M., Tan, K., Forsyth, L.M.G., and Lamb, J.R.

Abstract

Signals derived from antigen-presenting cells (APC) influence the functional differentiation of CD4+ T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, may contribute to the differentiation of peripheral CD4+ T cells into either helper or regulatory cells. Our findings demonstrate that antigen presented by murine APC overexpressing human Serrate1 induces naive peripheral CD4+ T cells to become regulatory cells. These cells can inhibit primary and secondary immune responses, and transfer antigen-specific tolerance to recipient mice. Our results show that Notch signalling may help explain `linked' suppression in peripheral tolerance, whereby tolerance induced to one epitope encompasses all epitopes on that antigen during the course of an immune response.

Published
2000

42. Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells.

Author

Hoyne, G F, Le Roux, I, Corsin-Jimenez, M, Tan, K, Dunne, J, Forsyth, L M, Dallman, M J, Owen, M J, Ish-Horowicz, D, and Lamb, J R

Abstract

Signals derived from antigen-presenting cells (APC) influence the functional differentiation of CD4(+) T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, may contribute to the differentiation of peripheral CD4(+) T cells into either helper or regulatory cells. Our findings demonstrate that antigen presented by murine APC overexpressing human Serrate1 induces naive peripheral CD4(+) T cells to become regulatory cells. These cells can inhibit primary and secondary immune responses, and transfer antigen-specific tolerance to recipient mice. Our results show that Notch signalling may help explain 'linked' suppression in peripheral tolerance, whereby tolerance induced to one epitope encompasses all epitopes on that antigen during the course of an immune response.

Published
2000
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47. Floods in Var, South Easthern France, January 2014 – Involvement of local and national actors in an experience feedback

Author

Esposito Christophe, Fromental Anne-Marie, Alquier Mathieu, and Roux Isabelle

Subjects
Environmental sciences, GE1-350
Abstract

The feedback of January 2014 floods in Var is the object of a 3 parts report. The one at stake is dedicated to the event characterization. This work requires that State services, public administrative establishments, local and regional authorities and the main technical actors of the territory work together. The nature, intensity and return period of phenomena are defined and compared with past studies or past events. On the Argens river, January 2014 flood is not the reference event, the peak-discharge is lower than those observed during the 2010 and 2011 major events which were considered for the PPRI elaboration. For Gapeau and other coastal rivers, January 2014 event gets closer or exceeds the flows estimated for the PPRI reference event. In the end, recommendations for the capitalization of feedback elements for potential future floods are given.

Published
2016
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49. Ovarian cryopreservation after laparoscopic ovariectomy using the Endo-GIA stapling device and LAPRO-clip absorbable ligating clip in a woman: a case report

Author

Messner Alexandra, Linehan Jenna, Grynberg Michaël, Roux Isabelle, and Deffieux Xavier

Subjects
Medicine
Abstract

Abstract Introduction Several options are available for preserving fertility before cytotoxic treatment, including ovarian tissue cryopreservation. Most reported surgical techniques include electrocoagulation. Our hypothesis is that avoidance of electrocoagulation may decrease ovarian cortex injury during cryopreservation procedures. Case presentation We report a laparoscopic technique of whole-ovary removal without coagulation using Endo-GIA forceps and clips. Laparoscopic ovariectomy was performed for cryopreservation in a 37-year-old Caucasian woman with breast cancer and for whom chemotherapy was planned. The procedure was completed quickly and without complication. This Endo-GIA procedure was of short duration with a short period of ischemia before freezing. Conclusion Laparoscopic ovariectomy using the Endo-GIA stapling device procedure without coagulation may diminish ovary injury before ovarian cryopreservation.

Published
2011
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50. Characterization of efferent inputs to the inner hair cells before hearing onset.

Author

Roux, I.

Subjects
*AFFERENT pathways, *COCHLEA, *DEPOLARIZATION (Cytology)
Abstract

In vivo recordings show that cochlear afferent neurons fire bursts of action potentials from P0 on (1), about two weeks before hearing onset in rats. This 'spontaneous' activity of the auditory nerve fibers is driven by glutamate release from inner hair cells (IHCs), that themselves can fire spontaneous calcium action potentials. By analogy to retinal development, it has been suggested that such a spontaneous activity may promote the survival and functional maturation of auditory neurons and guide the refinement of synaptic connections in the auditory brainstem (for review see (2)). Different mechanisms have been shown to contribute to IHCs depolarization. Those include the release of ATP from supporting cells, which drive bursts of action potentials in auditory nerve fibers for most of the postnatal, pre-hearing period (3). Resting level of activation of the mechanotransduction channels, present in the sensory cells from post natal day 1 to post natal day 3 (P1/P3) on, may also contribute to the IHCs depolarization. Interestingly, P0 is also the age at which the cholinergic efferent axons originating in the superior olive complex, are first observed in close vicinity to the IHCs and seem to make initial contact ((4), for review see (5)). Here, I will present recent results obtained using ex vivo whole cell recordings, immunohistochemistry and imaging, which demonstrate a 'developmental switch' whereby the hair cell's cholinergic response changes from excitatory to inhibitory during synapse formation. Thus, as in vertebrate skeletal muscle, the nicotinic acetylcholine receptors (nAChRs), most likely formed by α9 and α10 nAChRs subunits (6), are functional and present in the sensory hair cell plasma membrane before synapses are formed. Then, in a second step, nAChRs clustering, coupling to calcium-dependent small conductance potassium channels (SK2) and synaptic currents appear, suggesting that efferent synaptic function is contemporaneous with, and may require, SK2 channel expression, a hypothesis consistent with the lack of functional efferent activity reported in SK2 knockout IHCs (7). [ABSTRACT FROM AUTHOR]

Published
2013

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